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1. Modeling long-term HIV dynamics and antiretroviral response: Effects of drug potency, pharmacokinetics, adherence, and drug resistance

Author

Hulin Wu, Yangxin Huang, Acosta, Edward P., Perelson, Alan S., Rosenkranz, Susan L., Gerber, John J., Kuritzkes, Daniel R., and Eron, Joseph J.

Subjects
Drug resistance -- Analysis, HIV infection -- Research, Bayesian statistical decision theory -- Models, Health
Abstract

A long-term HIV-1 dynamic model by considering drug potency, drug exposure, and drug susceptibility was proposed and HIV-1 dynamic parameters were estimated. A large between-subject variation in estimated viral dynamic parameters was observed, even after accounting for variations in drug exposure and drug susceptibility and it is suggested that the characteristics of HIV-1 dynamics are host-dependent.

Published
2005

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