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1. Effect of liraglutide in different abdominal fat layers measured by ultrasound. The importance of perirenal fat reduction

Author

Guillem Cuatrecasas, Marta Calbo, Olga Rossell, Laia Dachs, Gerardo Aguilar-Soler, Maria-José Coves, Ioana Patrascioiu, Camila Eugenia Benito, Sonia March, Mariona Balfegó, Gabriel Cuatrecasas, Silvana Di Gregorio, Inaki Marina, Pilar Garcia-Lorda, Elena Munoz-Marron, and Francisco De Cabo

Subjects
Nutrition. Foods and food supply, TX341-641, Nutritional diseases. Deficiency diseases, RC620-627
Abstract

Introduction: Ultrasonography in patients with Obesity allows us to measure different layers of abdominal fat (Superficial subcutaneous, Deep subcutaneous, Preperitoneal, Omental and Perirenal), not assessable by DEXA or CT scan. Omental and Perirenal fat depots are considered predictors of metabolic complications. Liraglutide is particularly effective in reducing weight in patients with insulin-resistance, but its direct impact on each abdominal fat layer is unknown. Methods: We measured, at the L4 level, all 5 abdominal fat depots in 860 patients with obesity (72.8% women. Mean age 56.6±1.5 years. BMI 34.4±4.7 kg/m2. Body fat 47±2%. Abdominal circumference 105.8±3 cm), before and after 6 months of Liraglutide treatment. Laboratory tests for glucose, insulin and lipid profile were routinely done. T-student was used to compare intra-individual differences. Results: Weight loss was 7.5±2.8 Kg (7.96% from baseline), with no differences by sex/age/BMI. Greater loss was observed in patients with higher dosages and NAFLD. All US-measured fat layers showed a significant reduction (p

Published
2024
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2. SAT-LB020 Use of Ultrasound to Characterize Abdominal Adipose Tissue Distribution and Its Impact on Metabolic Syndrome

Author

Maria Jose Coves, Pilar García-Lorda, Ioana Patrascioiu, Gerardo Aguilar-Soler, Sonia March, Francisco DeCabo, and Guillem Cuatrecasas Cambra

Subjects
Pathology, medicine.medical_specialty, Adipose Tissue, Appetite, and Obesity, business.industry, Endocrinology, Diabetes and Metabolism, Ultrasound, medicine, Distribution (pharmacology), Adipose tissue, Metabolic syndrome, medicine.disease, business, Obesity Comorbidities and Therapies
Abstract

Body fat distribution play a key role in metabolic syndrome pathogenesis. TC and DEXA imaging allow us to differentiate abdominal subcutaneous from visceral fat. Ultrasound (US) imaging, widely used in thyroid assessment, further allows us to differentiate other abdominal layers: superficial and profound subcutaneous, pre-peritoneal, omental and perirenal (retroperitoneal) fat. Our aim was to measure these layers and correlate them with anthropometric parameters and metabolic syndrome (MS) clinical features. US (GE logic E©) measurement of different abdominal fat layers were done at 397 consecutive patients (28% male 72% female) that came for conventional US for any reason. 12 MHz linear probe for superficial layers and 5 MHz convex probe for intra-abdominal layers assessment have been used. All measures were done at L4 vertebra level to allow comparison with DEXA/CT. Age (16-77 y.o), BMI (22,3-44,7 Kg/m2), abdominal perimeter, % body fat, glucose, HDL, LDL, total cholesterol, triglycerides and HOMA index were recorded. MS criteria were assessed using ATPIII classification. Women showed higher (superficial and profound) subcutaneous fat depots, while men had bigger omental and perirenal fat (p

Published
2019

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