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1. Diagnostic accuracy of cell‐free DNA in maternal blood in detecting chromosomal anomalies in twin pregnancies: systematic review and meta‐analysis

Author

Della Valle, L., primary, Piergianni, M., additional, Khalil, A., additional, Novelli, A., additional, Rizzo, G., additional, Mappa, I., additional, Prasad, S., additional, Matarrelli, B., additional, Gatta, V., additional, Stuppia, L., additional, Pagani, G., additional, Flacco, M. E., additional, and D'Antonio, F., additional

Published
2024
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2. Early and sustained altered expression of aging-related genes in young 3xTg-AD mice

Author

Gatta, V, D'Aurora, M, Granzotto, A, Stuppia, L, and Sensi, S L

Subjects
Alzheimer's disease, aging, microarray, inflammation, synaptic plasticity, mitochondriaalzheimers-disease brain, amyloid precursor protein, long-term potentiation, a-beta, mouse model, mitochondria, activation, calcium, growth, overexpression
Published
2014

3. A novel role in skeletal segment regeneration of extracellular vesicles released from periodontal-ligament stem cells

Author

Diomede F, D'Aurora M, Gugliandolo A, Merciaro I, Ettorre V, Bramanti A, Piattelli A, Gatta V, Mazzon E, Fontana A, and Trubiani O

Subjects
Human periodontal ligament stem cells, living construct, extracellular vesicles, bone regeneration, collagen membrane., Medicine (General), R5-920
Abstract

Francesca Diomede,1 Marco D’Aurora,2 Agnese Gugliandolo,3 Ilaria Merciaro,1 Valeria Ettorre,4 Alessia Bramanti,3,5 Adriano Piattelli,1 Valentina Gatta,2 Emanuela Mazzon,3 Antonella Fontana,4 Oriana Trubiani1 1Department of Medical, Oral, and Biotechnological Sciences, University “G. d’Annunzio”, Chieti, Italy; 2Department of Psychological, Health, and Territorial Sciences, University “G. d’Annunzio”, Chieti, Italy; 3Department of Experimental Neurology, IRCCS Centro Neurolesi “Bonino Pulejo”, Messina, Italy; 4Department of Pharmacy, University “G. d’Annunzio”, Chieti, Italy; 5Eduardo Caianiello Institute of Applied Science and Intelligent Systems (ISASI), National Research Council, Messina, Italy Purpose: The combination of oral derived stem cells and 3-D scaffolds is considered advantageous in bone repair. In particular, collagen membranes possess ideal biological properties and can support infiltration and proliferation of osteoblasts, promoting bone regeneration. Our study aimed to develop a new biocompatible osteogenic construct composed of a commercially available collagen membrane (Evolution [Evo]), human periodontal-ligament stem cells (hPDLSCs) enriched with extracellular vesicles (EVs), or polyethylenimine (PEI)-engineered EVs (PEI-EVs). Methods: Osteogenic ability and expression of osteogenic genes were evaluated in vitro in hPDLSCs cultured with or without Evo, with Evo and EVs, or PEI-EVs. In addition, the bone-regeneration capacity of Evo, Evo enriched with hPDLSCs, Evo enriched with hPDLSCs and EVs/PEI-EVs was investigated in rats subjected to calvarial defects. Results: Our results showed that Evo enriched with EVs and PEI-EVs showed high biocompatibility and osteogenic properties in vitro and in vivo. In addition, quantitative reverse-transcription polymerase chain reaction demonstrated the upregulation of osteogenic genes, such as TGFB1, MMP8, TUFT1, TFIP11, BMP2, and BMP4, in the presence of PEI-EVs. Upregulation of BMP2/4 was confirmed for Evo enriched with PEI-EVs and hPDLSCs both in vitro by Western blot and in vivo by immunofluorescence. Conclusion: Our results indicated that Evo enriched with hPDLSCs and PEI-EVs is able to promote a bone-regeneration process for the treatment of calvarium and ossification defects caused by accidental or surgery trauma. In particular, PEI-EVs had a significant role in activation of the osteogenic process. Keywords: human periodontal-ligament stem cells, living construct, extracellular vesicles, bone regeneration, collagen membrane

Published
2018

7. Impatto del lockdown sulla spesa degli italiani: quale futuro per l’e-grocery?

Author

Sernicola F., Maltese I., Gatta V., Iannaccone G., Marcucci E., Sernicola, F., Maltese, I., Gatta, V., Iannaccone, G., and Marcucci, E.

Abstract

I decisori politici e gli operatori del settore si stanno impegnando in nuovi progetti volti a minimizzare l’impatto ambientale del trasporto merci dell’ultimo miglio. A questo scopo potrebbe risultare funzionale l’evoluzione verso la modalità di spesa online (e-grocery) laddove, grazie a un servizio pianificato di consegna delle merci, riuscisse a ridurre il numero di viaggi e/o di veicoli circolanti e, di conseguenza, le esternalità negative legate al settore del trasporto merci urbano. Il “lockdown di primavera”, imposto tra marzo e maggio del 2020 per contrastare il diffondersi della pandemia da SARS-Covid19, ha avuto un impatto importante su qualità e quantità degli spostamenti, che sono calati drasticamente per via delle restrizioni governative agli spostamenti vigenti sui vari territori nazionali. In questo lavoro si intende dunque esplorare se e in che misura le famiglie italiane abbiano modificato, durante il periodo di lockdown, le proprie abitudini nell’effettuare la spesa, eventualmente preferendo la modalità online. Inoltre si cerca di capire anche se tale modifica del comportamento potrebbe prolungarsi al termine del periodo di restrizioni. A questo scopo TRElab ha somministrato online un questionario su scala nazionale a più di 600 rispondenti. I risultati dello studio mostrano non solo che il lockdown ha contribuito, spesso per mancanza di alternative, a spingere le famiglie italiane verso nuove modalità di acquisto e ricezione della spesa, con un conseguente incremento del flusso di richieste per il comparto dell’e-grocery, ma evidenziano una propensione all’utilizzo del canale di vendita virtuale per la spesa anche in un prossimo futuro

Published
2020

19. Eco-labeling and sustainable urban freight transport : How much are people willing to pay for green logistics ?

Author

Polinori P., Marcucci E., Gatta V., Bigerna S., Andrea Bollino C., Micheli S., Polinori, P., Marcucci, E., Gatta, V., Bigerna, S., Andrea Bollino, C., and Micheli, S.

Subjects
Green urban freight transport, CO2 emission, Willingness to pay, Sustainable consumption
Abstract

Freight transport is responsible for a relevant percentage of CO2 emissions. Policies aimed at stimulating green freight transport should mitigate the CO2 emissions that the transport sector produces. Fostering consumer's green behavior is fundamental to reduce the impact transportation has on the environment. One can pursue this goal by stimulating consumer's intention to purchase goods that are delivered in an eco-friendly fashion. This paper investigates consumer's choices and estimates how much youngers are willing to pay for green urban freight distribution. A questionnaire-based web survey among a group of 350 Italian university students was conducted using a stated preference approach to estimate their willingness to pay for green urban distribution. The results obtained are relevant for retailers and/or transport providers who are interested in knowing if consumers' willingness is sufficient to compensate for the additional costs they have to incur to reduce polluting emissions. The results show that : 1) students, in general, are quite concerned about the environmental impact freight transport produces, responsive to pro-environmental issues and attentive to opinion makers ; 2) females and public transport users are more responsive to green freight deployment. These findings have interesting policy implications, suggesting to channel specific government-sponsored information campaigns toward these population groups to stimulate their green logistic responsive behavior thus inducing a demand for cleaner shipment of goods in cities.

Published
2018

26. Placental Stem Cells from Domestic Animals

Author

Barboni, B., primary, Russo, V., additional, Berardinelli, P., additional, Mauro, A., additional, Valbonetti, L., additional, Sanyal, H., additional, Canciello, A., additional, Greco, L., additional, Muttini, A., additional, Gatta, V., additional, Stuppia, L., additional, and Mattioli, M., additional

Published
2018
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30. Multicolor FISH analysis in ten patients with acute lymphoblastic leukemia

Author

Calabrese, G., Taraborelli, T., Fantasia, D., Morizio, E., Franchi, P. Guanciali, Gatta, V., Spadano, A., Stuppia, L., and Palka, G.

Subjects
Genetic disorders -- Research, Human chromosome abnormalities -- Research, Human genetics -- Research, In situ hybridization -- Usage, Lymphocytic leukemia -- Genetic aspects, Biological sciences
Published
2001

34. High prevalence of BRCA1 deletions in BRCAPRO-positive patients with high carrier probability

Author

VESCHI S, ACETO G, SCIOLETTI AP, GATTA V, PALKA G, CAMA A, MARIANI COSTANTINI, R, BATTISTA P, CALO', Valentina, BARBERA, Floriana, BAZAN, Viviana, RUSSO, Antonio, STUPPIA L., VESCHI S, ACETO G, SCIOLETTI AP, GATTA V, PALKA G, CAMA A, MARIANI-COSTANTINI, BATTISTA P, CALO V, BARBERA F, BAZAN V, RUSSO A, and STUPPIA L

Subjects
Adult, Male, Oncology, Proband, congenital, hereditary, and neonatal diseases and abnormalities, medicine.medical_specialty, endocrine system diseases, Breast Neoplasms, Germline, Breast Neoplasms, Male, Germline mutation, Breast cancer, Risk Factors, Internal medicine, Prevalence, Humans, Medicine, Genetic Predisposition to Disease, Multiplex, Multiplex ligation-dependent probe amplification, skin and connective tissue diseases, Aged, Sequence Deletion, Ovarian Neoplasms, Genetics, BRCA1 Protein, business.industry, Genetic Carrier Screening, Prostatic Neoplasms, Hematology, Middle Aged, medicine.disease, BRCA1, BRCA2, BRCAPro, breast cancer, MLPA, ovarian cancer, Pedigree, Mutation (genetic algorithm), Female, business, Ovarian cancer, Software
Abstract

Mutation screening of the BRCA1 and BRCA2 genes in probands with familial breast/ovarian cancer has been greatly improved by the multiplex ligation-dependent probe amplification (MLPA) assay able to evidence gene rearrangements not detectable by standard screening methods. However, no criteria for selection of cases to be submitted to the MLPA test have been reported yet. We used the BRCAPro software for the selection of familial breast/ovarian cancer probands investigated with the MLPA approach after negative BRCA1/2 conventional mutation screening. One hundred and seventy-seven probands were investigated for germline BRCA1/2 mutations after assessment of genetic risk using BRCAPro. Probands were classified as BRCAPro positive (n = 67) when the carrier probability (CP) was >10% and as BRCAPro negative (n = 110), when the CP was 50%.

Published
2007

35. Poster session 2Morphogenetic mechanisms290MiR-133 regulates retinoic acid pathway during early cardiac chamber specification291Bmp2 regulates atrial differentiation through miR-130 during early heart looping formationDevelopmental genetics294Association of deletion allele of insertion/deletion polymorphism in alpha 2B adrenoceptor gene and hypertension with or without type 2 diabetes mellitus295Association of G1359A polymorphism of the endocannabinoid type 1 receptor (CNR1) with coronary artery disease (CAD) with type 2 diabetes mellitusCell growth, differentiation and stem cells - Vascular298Gamma-secretase inhibitor prevents proliferation and migration of ductus arteriosus smooth muscle cells: a role of Notch signaling in postnatal closure of ductus arteriosus299Mesenchymal stromal-like cells (MLCs) derived from induced pluripotent stem (iPS) cells: a promising therapeutic option to promote neovascularization300Sonic Hedgehog promotes mesenchymal stem cell differentiation to vascular smooth muscle cells in cardiovacsular disease301Proinflammatory cytokine secretion and epigenetic modification in endothelial cells treated LPS-GinfivalisCell death and apoptosis - Vascular304Mitophagy acts as a safeguard mechanism against human vascular smooth muscle cell apoptosis induced by atherogenic lipidsTranscriptional control and RNA species - Vascular307MicroRNA-34a role in vascular calcification308Local delivery of a miR-146a inhibitor utilizing a clinically applicable approach attenuates neointima formation after vascular injury309Long noncoding RNA landscape of hypoxic endothelial cells310Specific circulating microRNAs levels associate with hypertension, hyperglycemia and dysfunctional HDL in acute coronary syndrome patientsCytokines and cellular inflammation - Vascular313Phosphodiesterase5A up-regulation in vascular endothelium under pro-inflammatory conditions: a newly disclosed anti-inflammatory activity for the omega-3polyunsaturated aatty acid docosahexaenoic acid314Cardiovascular risk modifying with extra-low dose anticytokine drugs in rhematoid arthritis315Conversion of human M-CSF macrophages into foam cells reduces their proinflammatory responses to classical M1-polarizing activation316Lymphocytic myocarditis coincides with increased plaque inflammation and plaque hemorrhage in coronary arteries, facilitating myocardial infarction317Serum osteoprotegerin level predictsdeclined numerous of circulating endothelial- derived and mononuclear-derived progenitor cells in patients with metabolic syndromeGrowth factors and neurohormones - Vascular320Effect of gastrin-releasing peptide (GRP) on vascular inflammationSignal transduction - Heart323A new synthetic peptide regulates hypertrophy in vitro through means of the inhibition of nfkb324Inducible fibroblast-specific knockout of p38 alpha map kinase is cardioprotective in a mouse model of isoproterenol-induced cardiac hypertrophy325Regulation of beta-adrenoceptor-evoked inotropic responses by inhibitory G protein, adenylyl cyclase isoforms 5 and 6 and phosphodiesterases326Binding to RGS3 and stimulation of M2 muscarinic acetylcholine receptors modulates the substrate specificity of p190RhoGAP in cardiac myocytes327Cardiac regulation of post-translational modifications, parylation and deacetylation in LMNA dilated cardiomyopathy mouse model328Beta-adrenergic regulation of the b56delta/pp2a holoenzyme in cardiac myocytes through b56delta phosphorylation at serine 573Nitric oxide and reactive oxygen species - Vascular331Oxidative stress-induced miR-200c disrupts the regulatory loop among SIRT1, FOXO1 and eNOS332Antioxidant therapy prevents oxidative stress-induced endothelial dysfunction and Enhances Wound Healing333Morphological and biochemical characterization of red blood cell in coronary artery diseaseCytoskeleton and mechanotransduction - Heart336Novel myosin activator, JSH compounds, increased myocardial contractility without chronotropic effect in ratsExtracellular matrix and fibrosis - Vascular339Ablation of Toll-like receptor 9 causes cardiac rupture after myocardial infarction by attenuating proliferation and differentiation of cardiac fibroblasts340Altered vascular remodeling in the mouse hind limb ischemia model in Factor VII activating protease (FSAP) deficiencyVasculogenesis, angiogenesis and arteriogenesis343Pro-angiogenic effects of proly-hydroxylase inhibitors and their potential for use in a novel strategy of therapeutic angiogenesis for coronary total occlusion344Nrf2 drives angiogenesis in transcription-independent manner: new function of the master regulator of oxidative stress response345Angiogenic gene therapy, despite efficient vascular growth, is not able to improve muscle function in normoxic or chronically ischemic rabbit hindlimbs -role of capillary arterialization and shunting346Effect of PAR-1 inhibition on collateral vessel growth in the murine hind limb model347Quaking is a key regulator of endothelial cell differentiation, neovascularization and angiogenesis348"Emerging angiogenesis" in the chick chorioallantoic membrane (CAM). An in vivo study349Exosomes from cardiomyocyte progenitor cells and mesenchymal stem cells stimulate angiogenesis in vitro and in vivo via EMMPRINEndothelium352Reciprocal regulation of GRK2 and bradykinin receptor stimulation modulate Ca2+ intracellular level in endothelial cells353The roles of bone morphogenetic proteins 9 and 10 in endothelial inflammation and atherosclerosis354The contribution of GPR55 to the L-alpha-lysophosphatidylinositol-induced vasorelaxation in isolated human pulmonary arteries355The endothelial protective ACE inhibitor Zofenoprilat exerts anti-inflammatory activities through H2S production356A new class of glycomimetic drugs to prevent free fatty acid-induced endothelial dysfunction357Endothelial progenitor cells to apoptotic endothelial cell-derived microparticles ration differentiatesas preserved from reduced ejection fractionheart failure358Proosteogenic genes are activated in endothelial cells of patients with thoracic aortic aneurysm359Endothelin ETB receptors mediate relaxing responses to insulin in pericardial resistance arteries from patients with cardiovascular disease (CVD)Smooth muscle and pericytes362CX3CR1 positive myeloid cells regulate vascular smooth muscle tone by inducing calcium oscillations via activation of IP3 receptors363A novel function of PI3Kg on cAMP regulation, role in arterial wall hyperplasia through modulation of smooth muscle cells proliferation364NRP1 and NRP2 play important roles in the development of neointimal hyperplasia in vivo365Azithromycin induces autophagy in aortic smooth muscle cellsCoagulation, thrombosis and platelets368The real time in vivo evaluation of platelet-dependent aldosterone prothrombotic action in mice369Development of a method for in vivo detection of active thrombi in mice370The antiplatelet effects of structural analogs of the taurine chloramine371The influence of heparin anticoagulant drugs on functional state of human platelets372Regulation of platelet aggregation and adenosine diphosphate release by d dimer in acute coronary syndrome (in vitro study)Oxygen sensing, ischaemia and reperfusion375Sirtuin 5 mediates brain injury in a mouse model of cerebral ischemia-reperfusion376Abscisic acid: a new player in cardiomyocyte protection from ischaemia?377Protective effects of ultramicronized palmitoylethanolamide (PEA-um) in myocardial ischaemia and reperfusion injury in vivo378Identification of stem cell-derived cardiomyocytes using cardiac specific markers and additional testing of these cells in simulated ischemia/reperfusion system379Single-dose intravenous metformin treatment could afford significant protection of the injured rat kidney in an experimental model of ischemia-reperfusion380Cardiotoxicity of long acting muscarinic receptor antagonists used for chronic obstructive pulmonary disease381Dependence antioxidant potential on the concentration of amino acids382The impact of ischemia-reperfusion on physiological parameters,apoptosis and ultrastructure of rabbit myocardium with experimental aterosclerosisMitochondria and energetics385MicroRNA-1 dependent regulation of mitochondrial calcium uniporter (MCU) in normal and hypertrophied hearts386Mitochondrial homeostasis and cardioprotection: common targets for desmin and aB-crystallin387Overexpression of mitofusin-2 (Mfn2) and associated mitochondrial dysfunction in the diabetic heart388NO-dependent prevention of permeability transition pore (MPTP) opening by H2S and its regulation of Ca2+ accumulation in rat heart mitochondria389G protein coupled receptor kinase 2 (GRK2) is fundamental in recovering mitochondrial morphology and function after exposure to ionizing radiation (IR)Gender issues392Sex differences in pulmonary vascular control; focus on the nitric oxide pathwayAging395Heart failure with preserved ejection fraction develops when feeding western diet to senescence-accelerated mice396Cardiovascular markers as predictors of cognitive decline in elderly hypertensive patients397Changes in connexin43 in old rats with volume overload chronic heart failureGenetics and epigenetics400Calcium content in the aortic valve is associated with 1G>2G matrix metalloproteinase 1 polymorphism401Neuropeptide receptor gene s (NPSR1) polymorphism and sleep disturbances402Endothelin-1 gene Lys198Asn polymorphism in men with essential hypertension complicated and uncomplicated with chronic heart failure403Association of common polymorphisms of the lipoprotein lipase and pon1 genes with the metabolic syndrome in a sample of community participantsGenomics, proteomics, metabolomics, lipidomics and glycomics405Gene expression quantification using multiplexed color-coded probe pairs to determine RNA content in sporadic cardiac myxoma406Large-scale phosphorylation study of the type 2 diabetic heart subjected to ischemia / reperfusion injury407Transcriptome-based identification of new anti-inflammatory properties of the olive oil hydroxytyrosol in vascular endothelial cell under basal and proinflammatory conditions408Gene polymorphisms combinations and risk of myocardial infarctionComputer modelling, bioinformatics and big data411Comparison of the repolarization reserve in three state-of-the-art models of the human ventricular action potentialMetabolism, diabetes mellitus and obesity414Endothelial monocyte-activating polypeptide-II improves heart function in type -I Diabetes mellitus415Admission glucose level is independent predictor of impaired left ventricular function in patients with acute myocardial infarction: a two dimensional speckle-tracking echocardiography study416Association between biochemical markers of lipid profile and inflammatory reaction and stiffness of the vascular wall in hypertensive patients with abdominal obesity417Multiple common co-morbidities produce left ventricular diastolic dysfunction associated with coronary microvascular dysfunction, oxidative stress and myocardial stiffening418Investigating the cardiovascular effects of antiretroviral drugs in a lean and high fat/sucrose diet rat model of obesity419Statins in the treatment of non-alcoholic steatohepatitis (NASH). Our experience from a 2-year prospective study in Constanta County, Romania420Epicardial adipose tissue as a predictor of cardiovascular outcome in patients with ACS undergoing PCI?Arterial and pulmonary hypertension423Dependence between heart rhythm disorers and ID polymorphism of ACE gene in hypertensive patients424Molecular mechanisms underlying the beneficial effects of Urocortin 2 in pulmonary arterial hypertension425Inhibition of TGf-b axis and action of renin-angiotensin system in human ascending aorta aneurysms426Early signs of microcirculation and macrocirculation abnormalities in prehypertension427Vascular smooth muscle cell-expressed Tie-2 controls vascular tone428Cardiac and vascular remodelling in the development of chronic thrombo-embolic pulmonary hypertension in a novel swine modelBiomarkers431Arrhythmogenic cardiomyopathy: a new, non invasive biomarker432Can circulating microRNAs distinguish type 1 and type 2 myocardial infarction?433Design of a high-throughput multiplex proteomics assay to identify left ventricular diastolic dysfunction in diabetes434Monocyte-derived and P-selectin-carrying microparticles are differently modified by a low fat diet in patients with cardiovascular risk factors who will and who will not develop a cardiovascular event435Red blood cell distribution width assessment by polychromatic interference microscopy of thin films in chronic heart failure436Invasive and noninvasive evaluation of quality of radiofrequency-induced cardiac denervation in patients with atrial fibrillation437The effect of therapeutic hypothermia on the level of brain derived neurotrophic factor (BDNF) in sera following cardiopulmonary resustitation438Novel biomarkers to predict outcome in patients with heart failure and severe aortic stenosis439Biological factors linking depression and anxiety to cardiovascular disease440Troponins and myoglobin dynamic at coronary arteries graftingInvasive, non-invasive and molecular imaging443Diet composition effects on the genetic typing of the mouse ob mutation: a micro-ultrasound characterization of cardiac function, macro and micro circulation and liver steatosis444Characterization of pig coronary and rabbit aortic lesions using IV-OCT quantitative analysis: correlations with histologyGene therapy and cell therapy447Enhancing the survival and angiogenic potential of mouse atrial mesenchymal cells448VCAM-1 expression in experimental myocardial infarction and its relation to bone marrow-derived mononuclear cell retentionTissue engineering451Advanced multi layered scaffold that increases the maturity of stem cell-derived human cardiomyocytes452Response of engineered heart tissue to simulated ischemia/reperfusion in the presence of acute hyperglycemic conditions453Serum albumin hydrogels prevent de-differentiation of neonatal cardiomyocytes454A novel paintbrush technique for transfer of low viscosity ultraviolet light curable cyan methacrylate on saline immersed in-vitro sheep heart

Author

Garcia-Martinez, V, primary, Lopez Sanchez, C, primary, Hamed, W, primary, Hsu, JH, primary, Ferrer-Lorente, R, primary, Alshamrani, Maryam, primary, Pizzicannella, J, primary, Vindis, C, primary, Badi, I, primary, Korte, L, primary, Voellenkle, C, primary, Niculescu, L S, primary, Massaro, M, primary, Babaeva, AR, primary, Da Silva, F, primary, Woudstra, L, primary, Berezin, A, primary, Bae, MK, primary, Del Giudice, C, primary, Bageghni, S A, primary, Krobert, K, primary, Levay, M, primary, Vignier, N, primary, Ranieri, A, primary, Magenta, A, primary, Orlandi, A, primary, Porro, B, primary, Jeon, E-S, primary, Omori, Y, primary, Herold, J, primary, Barnett, G A, primary, Grochot-Przeczek, A, primary, Korpisalo, P, primary, Deffge, C, primary, Margariti, A, primary, Rong, W, primary, Maring, JA, primary, Gambardella, J, primary, Mitrofan, CG, primary, Karpinska, O, primary, Morbidelli, L, primary, Wilkinson, FL, primary, Kostina, AS, primary, De Mey, J G R, primary, Kumar, A, primary, Lupieri, A, primary, Pellet-Many, C, primary, Stamatiou, R, primary, Gromotowicz, A, primary, Dickhout, A, primary, Murina, M, primary, Roka-Moiia, YM, primary, Malinova, L, primary, Diaz-Canestro, C, primary, Vigliarolo, T, primary, Cuzzocrea, S, primary, Szantai, A, primary, Medic, B, primary, Cassambai, S, primary, Korda, A, primary, Revnic, C R, primary, Borile, G, primary, Diokmetzidou, A, primary, Murfitt, L, primary, Budko, A, primary, Fiordelisi, A, primary, De Wijs-Meijler, DPM, primary, Gevaert, AB, primary, Noriega De La Colina, A, primary, Benes, J, primary, Guillermo Solache Berrocal, GSB, primary, Gafarov, V, primary, Zhebel, VM, primary, Prakaschandra, R, primary, Stepien, E L, primary, Smith, LE, primary, Carluccio, MA, primary, Timasheva, Y, primary, Paci, M, primary, Dorofeyeva, N A, primary, Chimed, CH, primary, Petelina, TI, primary, Sorop, O, primary, Genis, A, primary, Parepa, I R, primary, Tscharre, M, primary, Krestjyaninov, MV, primary, Maia-Rocha, C, primary, Borges, L, primary, Sasonko, M L, primary, Kapel, SS, primary, Stam, K, primary, Sommariva, E, primary, Stojkovic, S, primary, O'reilly, J, primary, Chiva-Blanch, G, primary, Evtushenko, A, primary, Skopal, J, primary, Sunderland, N, primary, Gegenava, T, primary, Charnaia, MA, primary, Di Lascio, N, primary, Tarvainen, SJ, primary, Malandraki-Miller, S, primary, Uitterdijk, A, primary, Benzoni, P, primary, Ruivo, E, primary, Humphrey, E J, primary, Arokiaraj, MC, primary, Franco, D, additional, Garcia-Lopez, V, additional, Aranega, A, additional, Lopez-Sanchez, C, additional, Garcia-Martinez, V, additional, Tayel, S, additional, Khader, H, additional, El-Helbawy, N, additional, Alrefai, A, additional, El-Barbary, H, additional, Wu, JR, additional, Dai, ZK, additional, Yeh, JL, additional, Sanjurjo-Rodriguez, C, additional, Richaud-Patin, Y, additional, Blanco, FJ, additional, Badimon, L, additional, Raya, A, additional, Cahill, Paul A, additional, Diomede, F, additional, Merciaro, I, additional, Trubiani, O, additional, Nahapetyan, H, additional, Swiader, A, additional, Faccini, J, additional, Boya, P, additional, Elbaz, M, additional, Zeni, F, additional, Burba, I, additional, Bertolotti, M, additional, Capogrossi, MC, additional, Pompilio, G, additional, Raucci, A, additional, Widmer-Teske, R, additional, Dutzmann, J, additional, Bauersachs, J, additional, Donde, K, additional, Daniel, JM, additional, Sedding, DG, additional, Simionescu, N, additional, Sanda, GM, additional, Carnuta, MG, additional, Stancu, CS, additional, Popescu, AC, additional, Popescu, MR, additional, Vlad, A, additional, Dimulescu, DR, additional, Sima, AV, additional, Scoditti, E, additional, Pellegrino, M, additional, Calabriso, N, additional, Carluccio, MA, additional, Storelli, C, additional, De Caterina, R, additional, Solodenkova, KS, additional, Kalinina, EV, additional, Usachiova, MN, additional, Lappalainen, J, additional, Lee-Rueckert, M DE C, additional, Kovanen, PT, additional, Biesbroek, PS, additional, Emmens, RWE, additional, Van Rossum, AC, additional, Juffermans, LJM, additional, Niessen, JWM, additional, Krijnen, PAJ, additional, Kremzer, A, additional, Samura, T, additional, Berezina, T, additional, Gronenko, E, additional, Kim, MK, additional, Park, HJ, additional, Bae, SK, additional, Sorriento, D, additional, Ciccarelli, M, additional, Vernieri, E, additional, Campiglia, P, additional, Trimarco, B, additional, Iaccarino, G, additional, Hemmings, K E, additional, Porter, K E, additional, Ainscough, J F, additional, Drinkhill, M J, additional, Turner, N A, additional, Hiis, HG, additional, Cosson, MV, additional, Levy, FO, additional, Wieland, T, additional, Macquart, C, additional, Chatzifrangkeskou, M, additional, Evans, A, additional, Bonne, G, additional, Muchir, A, additional, Kemp, E, additional, Avkiran, M, additional, Carlomosti, F, additional, D'agostino, M, additional, Beji, S, additional, Zaccagnini, G, additional, Maimone, B, additional, Di Stefano, V, additional, De Santa, F, additional, Cordisco, S, additional, Antonini, A, additional, Ciarapica, R, additional, Dellambra, E, additional, Martelli, F, additional, Avitabile, D, additional, Scioli, MG, additional, Bielli, A, additional, Agostinelli, S, additional, Tarquini, C, additional, Tarallo, V, additional, De Falco, S, additional, Zaninoni, A, additional, Fiorelli, S, additional, Bianchi, P, additional, Teruzzi, G, additional, Squellerio, I, additional, Turnu, L, additional, Lualdi, A, additional, Tremoli, E, additional, Cavalca, V, additional, Lee, YJ, additional, Ju, ES, additional, Choi, JO, additional, Lee, GY, additional, Lim, BK, additional, Manickam, MANOJ, additional, Jung, S-H, additional, Omiya, S, additional, Otsu, K, additional, Deffge, C, additional, Nowak, S, additional, Wagner, M, additional, Braun-Dullaeus, RC, additional, Kostin, S, additional, Francke, A, additional, Subramaniam, S, additional, Kanse, SM, additional, Al-Lamee, K, additional, Schofield, CJ, additional, Egginton, S, additional, Gershlick, AH, additional, Kloska, D, additional, Kopacz, A, additional, Augustyniak, A, additional, Dulak, J, additional, Jozkowicz, A, additional, Hytonen, J, additional, Halonen, P, additional, Taavitsainen, J, additional, Tarvainen, S, additional, Hiltunen, T, additional, Liimatainen, T, additional, Kalliokoski, K, additional, Knuuti, J, additional, Yla-Herttuala, S, additional, Weinert, S, additional, Isermann, B, additional, Lee, J, additional, Herold, J, additional, Cochrane, A, additional, Kelaini, S, additional, Bojdo, J, additional, Vila Gonzalez, M, additional, Hu, Y, additional, Grieve, D, additional, Stitt, A W, additional, Zeng, L, additional, Xu, Q, additional, Margariti, A, additional, Reglin, B, additional, Xiang, W, additional, Nitzsche, B, additional, Maibier, M, additional, Pries, AR, additional, Vrijsen, KR, additional, Chamuleau, SAJ, additional, Verhage, V, additional, Metz, CHG, additional, Lodder, K, additional, Van Eeuwijk, ECM, additional, Van Dommelen, SM, additional, Doevendans, PA, additional, Smits, AM, additional, Goumans, MJ, additional, Sluijter, JPG, additional, Bova, M, additional, Loffredo, S, additional, Appleby, S, additional, Morrell, N, additional, Baranowska-Kuczko, M, additional, Kloza, M, additional, Ambrozewicz, E, additional, Kozlowski, M, additional, Malinowska, B, additional, Kozlowska, H, additional, Monti, M, additional, Terzuoli, E, additional, Ziche, M, additional, Mahmoud, AM, additional, Jones, AM, additional, Wilkinson, JA, additional, Romero, M, additional, Duarte, J, additional, Alexander, MY, additional, Faggian, G, additional, Kostareva, AA, additional, Malashicheva, AB, additional, Leurgans, TM, additional, Nguyen, TN, additional, Irmukhamedov, A, additional, Riber, LP, additional, Mcgeogh, R, additional, Comer, S, additional, Blanco Fernandez, A, additional, Ghigo, A, additional, Blaise, R, additional, Smirnova, NF, additional, Malet, N, additional, Vincent, P, additional, Limon, I, additional, Gayral, S, additional, Hirsch, E, additional, Laffargue, M, additional, Mehta, V, additional, Zachary, I, additional, Aidonidis, I, additional, Kramkowski, K, additional, Miltyk, W, additional, Kolodziejczyk, P, additional, Gradzka, A, additional, Szemraj, J, additional, Chabielska, E, additional, Dijkgraaf, I, additional, Bitsch, N, additional, Van Hoof, S, additional, Verhaegen, F, additional, Koenen, R, additional, Hackeng, TM, additional, Roshchupkin, D I, additional, Buravleva, K V, additional, Sergienko, VI, additional, Zhernossekov, DD, additional, Rybachuk, VM, additional, Grinenko, TV, additional, Furman, N, additional, Dolotovskaya, P, additional, Shamyunov, M, additional, Denisova, T, additional, Reiner, M, additional, Akhmedov, A, additional, Keller, S, additional, Miranda, M, additional, Briand, S, additional, Barile, L, additional, Kullak-Ublick, G, additional, Luscher, T, additional, Camici, G, additional, Guida, L, additional, Magnone, M, additional, Ameri, P, additional, Lazzarini, E, additional, Fresia, C, additional, Bruzzone, S, additional, Zocchi, E, additional, Di Paola, R, additional, Cordaro, M, additional, Crupi, R, additional, Siracusa, R, additional, Campolo, M, additional, Bruschetta, G, additional, Fusco, R, additional, Pugliatti, P, additional, Esposito, E, additional, Paloczi, J, additional, Ruivo, E, additional, Gaspar, R, additional, Dinnyes, A, additional, Kobolak, J, additional, Ferdinandy, P, additional, Gorbe, A, additional, Todorovic, Z, additional, Krstic, D, additional, Savic Vujovic, K, additional, Jovicic, D, additional, Basta Jovanovic, G, additional, Radojevic Skodric, S, additional, Prostran, M, additional, Dean, S, additional, Mee, CJ, additional, Harvey, KL, additional, Hussain, A, additional, Pena, C, additional, Paltineanu, B, additional, Voinea, S, additional, Revnic, F, additional, Ginghina, C, additional, Zaglia, T, additional, Ceriotti, P, additional, Campo, A, additional, Carullo, P, additional, Armani, A, additional, Coppini, R, additional, Vida, V, additional, Olivotto, I, additional, Stellin, G, additional, Rizzuto, R, additional, De Stefani, D, additional, Sandri, M, additional, Catalucci, D, additional, Mongillo, M, additional, Soumaka, E, additional, Kloukina, I, additional, Tsikitis, M, additional, Makridakis, M, additional, Varela, A, additional, Davos, C, additional, Vlachou, A, additional, Capetanaki, Y, additional, Iqbal, MM, additional, Bennett, H, additional, Davenport, B, additional, Pinali, C, additional, Cooper, G, additional, Cartwright, E, additional, Kitmitto, A, additional, Strutynska, NA, additional, Mys, LA, additional, Sagach, VF, additional, Franco, A, additional, Verzijl, A, additional, Stam, K, additional, Van Duin, R, additional, Reiss, IKM, additional, Duncker, DJ, additional, Merkus, D, additional, Shakeri, H, additional, Orije, M, additional, Leloup, AJ, additional, Van Hove, CE, additional, Van Craenenbroeck, EM, additional, De Meyer, GRY, additional, Vrints, CJ, additional, Lemmens, K, additional, Desjardins-Creapeau, L, additional, Wu, R, additional, Lamarre-Cliche, M, additional, Larochelle, P, additional, Bherer, L, additional, Girouard, H, additional, Melenovsky, M, additional, Kvasilova, A, additional, Benes, J, additional, Ruskova, K, additional, Sedmera, D, additional, Ana Barral, ABV, additional, Martin Fernandez, M, additional, Pablo Roman Garcia, PRG, additional, Juan Carlos Llosa, JCLL, additional, Manuel Naves Diaz, MND, additional, Cesar Moris, CM, additional, Jorge B Cannata-Andia, JBCA, additional, Isabel Rodriguez, IR, additional, Voevoda, M, additional, Gromova, E, additional, Maximov, V, additional, Panov, D, additional, Gagulin, I, additional, Gafarova, A, additional, Palahniuk, H, additional, Pashkova, IP, additional, Zhebel, NV, additional, Starzhynska, OL, additional, Naidoo, DP, additional, Rawojc, K, additional, Enguita, F J, additional, Grudzien, G, additional, Cordwell, SJ, additional, White, MY, additional, Massaro, M, additional, Martinelli, R, additional, Gatta, V, additional, Nasibullin, TR, additional, Erdman, VV, additional, Tuktarova, IA, additional, Mustafina, OE, additional, Hyttinen, J, additional, Severi, S, additional, Vorobyov, GG, additional, Batmyagmar, KH, additional, Lkhagvasuren, Z, additional, Gapon, LI, additional, Musikhina, NA, additional, Avdeeva, KS, additional, Dyachkov, SM, additional, Heinonen, I, additional, Van Kranenburg, M, additional, De Beer, VJ, additional, Octavia, Y, additional, Van Geuns, RJ, additional, Van Den Meiracker, AH, additional, Van Der Velden, J, additional, Everson, FP, additional, Ogundipe, T, additional, Grandjean, T, additional, De Boever, P, additional, Goswami, N, additional, Strijdom, H, additional, Suceveanu, A I, additional, Suceveanu, A P, additional, Mazilu, L, additional, Tofoleanu, D E, additional, Catrinoiu, D, additional, Rohla, M, additional, Hauser, C, additional, Huber, K, additional, Wojta, H, additional, Weiss, TW, additional, Melnikova, MA, additional, Olezov, NV, additional, Gimaev, RH, additional, Khalaf, H, additional, Ruzov, VI, additional, Adao, R, additional, Mendes-Ferreira, P, additional, Santos-Ribeiro, D, additional, Rademaker, M, additional, Leite-Moreira, AF, additional, Bras-Silva, C, additional, Alvarenga, LAA, additional, Falcao, RSP, additional, Dias, RR, additional, Lacchini, S, additional, Gutierrez, PS, additional, Michel, JB, additional, Gurfinkel, YU I, additional, Atkov, O YU, additional, Teichert, M, additional, Korn, C, additional, Mogler, C, additional, Hertel, S, additional, Arnold, C, additional, Korff, T, additional, Augustin, HG, additional, Van Duin, RWB, additional, De Wijs-Meijler, DPM, additional, D'alessandra, Y, additional, Farina, F M, additional, Casella, M, additional, Catto, V, additional, Carbucicchio, C, additional, Dello Russso, A, additional, Stadiotti, I, additional, Brambilla, S, additional, Chiesa, M, additional, Giacca, M, additional, Colombo, G I, additional, Tondo, C, additional, Ahlin, F, additional, Andric, T, additional, Tihanyi, D, additional, Wojta, J, additional, O'connell, E, additional, Butt, A, additional, Murphy, L, additional, Pennington, S, additional, Ledwidge, M, additional, Mcdonald, K, additional, Baugh, J, additional, Watson, C, additional, Suades, R, additional, Crespo, J, additional, Estruch, R, additional, Dyachenko, A, additional, Ryabukho, V, additional, Evtushenko, V, additional, Saushkina, YU, additional, Lishmanov, YU, additional, Smyshlyaev, K, additional, Bykov, A, additional, Popov, S, additional, Pavlyukova, E, additional, Anfinogenova, Y, additional, Szigetfu, E, additional, Kapornai, B, additional, Forizs, E, additional, Jenei, ZS, additional, Nagy, Z, additional, Merkely, B, additional, Zima, E, additional, Cai, A, additional, Dworakowski, R, additional, Gibbs, T, additional, Piper, S, additional, Jegard, N, additional, Mcdonagh, T, additional, Gegenava, M, additional, Dementieva, II, additional, Morozov, YUA, additional, Barsanti, C, additional, Stea, F, additional, Lenzarini, F, additional, Kusmic, C, additional, Faita, F, additional, Halonen, PJ, additional, Puhakka, PH, additional, Hytonen, JP, additional, Taavitsainen, JM, additional, Supit, E A, additional, Carr, C A, additional, Groenendijk, BCW, additional, Gorsse-Bakker, C, additional, Panasewicz, A, additional, Sneep, S, additional, Tempel, D, additional, Van Der Giessen, WJ, additional, Rys, J, additional, Daraio, C, additional, Dell'era, P, additional, Pigler, J, additional, Eder, A, additional, Eschenhagen, T, additional, Mazo, M M, additional, Amdursky, N, additional, Peters, N S, additional, Stevens, M M, additional, and Terracciano, C M, additional

Published
2016
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36. DESIGN OF A STATED RANKING EXPERIMENT TO STUDY INTERACTIVE FREIGHT BEHAVIOUR: AN APPLICATION TO ROME'S LTZ

Author

Marcucci E., Stathopoulos A., Gatta V., and Valeri E.

Subjects
urban freight distribution, group decision making, agent-specific interaction, stated preference, stated ranking experiments
Abstract

City logistics policies require an understanding of several issues (e.g. freight distribution context, preferences and relationship among agents) seldom accounted for in current research. Policies run the risk of producing unsatisfactory results because behavioural and contextual aspects are not considered. The acquisition of relevant data is crucial to test hypothesis and forecast agents' reactions to policy changes. Despite recent methodological advances in modelling interactive behaviour the development of apt survey instruments is still lacking to test innovative policies acceptability. This paper expands and innovate the methodological literature by describing a stated ranking experiment to study freight agent interactive behaviour and discusses the experimental design implemented to incorporate agent-specific priors when efficient design techniques are employed.

Published
2011

40. Y-chromosomal DNA haplotypes in infertile European males carrying Y-microdeletions.

Author

Paracchini, S., Stuppia, L., Gatta, V., Palka, G., Moro, E., Foresta, C., Mengua, L., Oliva, R., Ballescà, J.L., Kremer, J.A.M., Golde, R.J.T. van, Tuerlings, J.H.A.M., Hargreave, T., Ross, A., Cooke, H., Huellen, K., Vogt, P.H., Tyler-Smith, C., Paracchini, S., Stuppia, L., Gatta, V., Palka, G., Moro, E., Foresta, C., Mengua, L., Oliva, R., Ballescà, J.L., Kremer, J.A.M., Golde, R.J.T. van, Tuerlings, J.H.A.M., Hargreave, T., Ross, A., Cooke, H., Huellen, K., Vogt, P.H., and Tyler-Smith, C.

Abstract

Item does not contain fulltext

Published
2000

42. Ascorbic acid and beta-carotene as modulators of oxidative damage.

Author

Cozzi, R, Ricordy, R, Aglitti, T, Gatta, V, Perticone, P, and De Salvia, R

Abstract

Naturally occurring antioxidants are extensively studied for their capacity to protect organisms and cells from damage induced by oxygen reactive species. In fact, oxidative stress is considered a cause of aging, degenerative disease and cancer. We have focused our attention on two agents, ascorbic acid and beta-carotene, commonly considered to be antioxidants, but whose protective activity against cancer is insufficiently known. This paper reports on the ability of these agents to act against damage induced by H2O2 and bleomycin, in Chinese hamster ovary cells cultivated in vitro. Cytogenetic and cytofluorimetric analyses were performed. Both vitamins proved effective in reducing H2O2-induced sister chromatid exchanges, but increased H2O2- and bleomycin-induced chromosomal aberrations. Cytofluorimetric data, in contrast, showed that ascorbic acid and beta-carotene act as scavengers of endogeneous and H2O2-induced oxygen species. [ABSTRACT FROM PUBLISHER]

Published
1997
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43. Loss of the SHOX gene associated with Leri-Weill dyschondrosteosis in a 45,X male

Author

Giannotti, A., Stuppia, L., Rappold, G.A., Calabrese, G., Gatta, V., Morizio, E., Palka, G., Borrelli, P., Crinò, A., Mingarelli, R., and Gilio, M.C. Di

Abstract

A male patient is reported with a 45,X karyotype and Leri-Weill dyschondrosteosis (LWD). FISH analysis with SHOX and SRY gene probes was carried out. One copy of both SHOX and SRY was detected in interphase nuclei, clarifying the origin of LWD and the male phenotype. Molecular results suggested that the 45,X karyotype arose through two independent events. The first occurred at paternal meiosis leading to an unequal crossing over between the short arms of the X and Y chromosomes. As a consequence, the SRY gene was translocated onto Xp, thereby explaining the male phenotype of the patient. The second event probably occurred at maternal meiosis or at the early stages of the zygote resulting in the loss of the maternal X chromosome.

Published
1999

44. P742 Transcriptome-based identification of new anti-anti-inflammatory properties of the omega-3 fatty acid docosahexaenoic acid in vascular endothelial cells under proinflammatory conditions.

Author

Massaro, M, Scoditti, E, Carluccio, MA, Martinelli, R, Buonuomo, T, Gatta, V, Storelli, C, and De Caterina, R

Subjects
ANTI-inflammatory agents, OMEGA-3 fatty acids, DOCOSAHEXAENOIC acid, VASCULAR endothelial cells, INFLAMMATION, DNA microarrays
Abstract

A high intake of the omega-3 polynsaturated fatty acids (PUFA) docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) has been associated with anti-inflammatory effects and cardiovascular protection, but the underlying molecular basis remains incompletely defined. Using a DNA microarray technology we investigated the early gene expression profile of human vascular endothelium conditioned by DHA under pro-inflammatory conditions.Methods: Human umbilical vein endothelial cells (HUVEC) were treated with 50 μmol/L DHA for 48 hours and then stimulated with 5 ng/mL IL-1β for 3 hours. Total RNA was extracted, and qualitatively/quantitatively analyzed with a NanoDrop spectrophotometer and an Agilent Bioanalyzer before RNA labeling and purification. Gene expression profile was performed with an Agilent Whole Human Genome Oligo Microarray covering 41 000 unique genes and transcripts. Slides were scanned with the Agilent's scanner and images processed using Agilent Feature Extraction software. The raw data were further processed with the GeneSpring® 10 software and differentially expressed RNA identified using Benjamini and Hochberg False Discovery Rate with a P-value <0.05. Functional and network analyses were identified by the Ingenuity Pathways version 8.0 Analysis.Results: Fixing a significance threshold at 1.5 fold of change, DHA alone significantly altered the expression of 188 genes, down-regulating 92 and up-regulating 96. IL-1β significantly changed the expression of 2031 genes, down-regulating 997 and up-regulating 1034. Treatment with DHA, before IL-1 significantly affected the expression of 116 IL-1β -deregulated genes. Immunological, inflammatory and metabolic pathways were the most affected. In particular, newly identified DHA-regulated genes were involved in stemness, cellular growth and proliferation, cardiovascular system development and function, and cancer. These included cytochrome p450 4F2 (CYP4F2), transforming growth factor (TGF)-β2, caspase recruitment domain (CARD)11, and the junctional adhesion molecule (JAM)-A.Conclusions: Endothelial exposure to DHA regulates several novel genes and related pathways. Such unbiased identification improves our understanding of mechanisms by which omega-3 PUFAs may affect human diseases. [ABSTRACT FROM AUTHOR]

Published
2014
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45. P741 Transcriptome-based identification of new anti-anti-inflammatory and vasodilating properties of the omega-3 polyunsaturated fatty acid docosahexaenoic acid in vascular endothelial cells under proinfla.

Author

Massaro, M, Scoditti, E, Carluccio, MA, Martinelli, R, Buonuomo, T, Gatta, V, Storelli, C, and De Caterina, R

Subjects
ANTI-inflammatory agents, GENETIC transcription, VASODILATION, OMEGA-3 fatty acids, UNSATURATED fatty acids, VASCULAR endothelial cells, CELL adhesion molecules
Abstract

A high intake of the omega-3 polynsaturated fatty acids (PUFA) docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) has been associated with anti-inflammatory effects and cardiovascular protection, but the underlying molecular basis remains incompletely defined. Using a DNA microarray technology we investigated the early gene expression profile of human vascular endothelium conditioned by DHA under pro-inflammatory conditions.Methods: Human umbilical vein endothelial cells (HUVEC) were treated with 50 μmol/L DHA for 48 hours and then stimulated with 5 ng/mL IL-1β for 3 hours. Total RNA was extracted, and qualitatively/quantitatively analyzed with a NanoDrop spectrophotometer and an Agilent Bioanalyzer before RNA labeling and purification. Gene expression profile was performed with an Agilent Whole Human Genome Oligo Microarray covering 41 000 unique genes and transcripts. Slides were scanned with the Agilent's scanner and images processed using Agilent Feature Extraction software. The raw data were further processed with the GeneSpring® 10 software and differentially expressed RNA identified using Benjamini and Hochberg False Discovery Rate with a P-value <0.05. Functional and network analyses were identified by the Ingenuity Pathways version 8.0 Analysis.Results: Fixing a significance threshold at 1.5 fold of change, DHA alone significantly altered the expression of 188 genes, down-regulating 92 and up-regulating 96. IL-1β significantly changed the expression of 2031 genes, down-regulating 997 and up-regulating 1034. Treatment with DHA, before IL-1 significantly affected the expression of 116 IL-1β -deregulated genes. Immunological, inflammatory and metabolic pathways were the most affected. In particular, newly identified DHA-regulated genes were involved in stemness, cellular growth and proliferation, cardiovascular system development and function, and cancer. These included cytochrome p450 4F2 (CYP4F2), transforming growth factor (TGF)-β2, caspase recruitment domain (CARD)11, and the junctional adhesion molecule (JAM)-A. Conclusions: Endothelial exposure to DHA regulates several novel genes and related pathways. Such unbiased identification improves our understanding of mechanisms by which omega-3 PUFAs may affect human diseases. [ABSTRACT FROM PUBLISHER]

Published
2014
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46. Simulating urban freight flows in e-grocery scenarios accounting for consumer heterogeneous preferences

Author

Alessandro Pluchino, Giuseppe Inturri, Edoardo Marcucci, Valerio Gatta, M. Le Pira, Matteo Ignaccolo, Martina Fazio, Le Pira, M., Marcucci, E., Gatta, V., Pluchino, A., Fazio, M., Inturri, G., & Ignaccolo, M., Pira, M. Le, Marcucci, E., Gatta, V., Pluchino, A., Fazio, M., Inturri, G., and Ignaccolo, M.

Subjects
Sustainability, ComputerApplications_COMPUTERSINOTHERSYSTEMS, Business, Environmental economics, Know-how, Latent class model
Abstract

E-grocery is a growing phenomenon that has the potential to rapidly change the way shopping is performed and goods distributed in cities. The impacts of this innovation can vary according to the delivery service performed, thus affecting positively or negatively the overall sustainability of urban freight transport. Understanding the dynamics of demand (i.e. consumers) will be useful to know how supply (i.e. supermarkets) should adapt, and how policy-makers should deal with this phenomenon. This paper presents an agent-based model to simulate different e-grocery scenarios at a neighbourhood scale. Agents are characterized with individual utility functions from a latent class model based on a stated preference survey performed in Rome (Italy). First results of a one-month simulation allow deriving some useful conclusion on the impact different grocery channels can have on travelled distance and consumer shopping time and formulating some policy implications.

Published
2020

49. Music Recommendation via Hypergraph Embedding

Author

Valerio La Gatta, Vincenzo Moscato, Mirko Pennone, Marco Postiglione, Giancarlo Sperli, La Gatta, V., Moscato, V., Pennone, M., Postiglione, M., and Sperli, G.

Subjects
Data model, Computer Networks and Communications, hypergraph, Neural network, information filtering, Computer Science Applications, Graph embedding, Streaming media, Artificial Intelligence, Data structure, Learning system, Rock, Recommender system, recommender systems, Software
Abstract

In recent years, we have witnessed an ever wider spread of multimedia streaming platforms (e.g., Netflix, Spotify, and Amazon). Hence, it has become more and more essential to provide such systems with advanced recommendation facilities, in order to support users in browsing these massive collections of multimedia data according to their preferences and needs. In this context, the modeling of entities and their complex relationships (e.g., users listening to topic-based songs or authors creating different releases of their lyrics) represents the key challenge to improve the recommendation and maximize the users' satisfaction. To this end, this is the first study to leverage the high representative power of hypergraph data structures in combination with modern graph machine learning techniques in the context of music recommendation. Specifically, we propose hypergraph embeddings for music recommendation (HEMR), a novel framework for song recommendation based on hypergraph embedding. The hypergraph data model allows us to represent seamlessly all the possible and complex interactions between users and songs with the related characteristics; meanwhile, embedding techniques provide a powerful way to infer the user-song similarities by vector mapping. We have experimented the effectiveness and efficiency of our approach with respect to the state-of-the-art most recent music recommender systems, exploiting the Million Song dataset. The results show that HEMR significantly outperforms other state-of-the-art techniques, especially in scenarios where the cold-start problem arises, thus making our system a suitable solution to embed within a music streaming platform.

Published
2022

50. An end-to-end framework for information extraction from Italian resumes

Author

Alessandro Barducci, Simone Iannaccone, Valerio La Gatta, Vincenzo Moscato, Giancarlo Sperlì, Sergio Zavota, Barducci, 63. A., Iannaccone, S., La Gatta, V., Moscato, V., Sperli', G., and Zavota, S.

Subjects
Artificial Intelligence, General Engineering, Information extraction, Job-person fitting, Neural network, Computer Science Applications
Abstract

Nowadays, recruitment processes are increasingly being automated by intelligent systems which provide best candidates for companies’ open positions, and vice versa. However, extracting information from the unstructured documents involved in these processes (e.g. resumes, jobs’ descriptions) still represents an open challenge because of their high heterogeneity (in the form and style) and the lack of pre-defined standards between different companies and/or countries. In this paper, we address the resume information extraction problem, focusing on documents within the Italian Labor Market. Specifically, we propose an effective and efficient end-to-end framework capable of providing a complete candidate overview including his personal information, skills and work experiences. Specifically, after having extracted the raw data from the resume documents, the system segments them into semantically consistent parts using linguistics patterns. Each segment is further processed with a NER algorithm, based on pre-trained language models, to extract relevant information which an HR specialist could consult in order to assess the suitability of a candidate for a job offer. We collected (and labeled) a new Italian resume dataset and our results prove the effectiveness of the proposed method, especially considering the great advantages our segmentation strategy brings to the NER performance with respect to standard line-based segmentation approaches. In addition, our system achieves promising performance when combined with modern NLP models.

Published
2022

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