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OBJECTIVE: This study examined if emergency department (ED) operational metrics, such as wait time or length of stay, are associated with interest in substance use disorder (SUD) treatment referral among patients at high risk of opioid overdose. METHODS: In this observational study, 648 ED patients at high risk of opioid overdose completed a baseline questionnaire. Operational metrics were summarized using electronic health record data. The association between operational metrics and treatment interest was estimated with multivariable logistic regression. RESULTS: Longer time to room (adjusted odds ratio [AOR]=1.12, 95% confidence interval [CI]=1.01-1.25) and length of stay (AOR=1.02, 95% CI=1.00-1.05) were associated with treatment referral interest. Time to provider and number of treating providers showed no significant association. CONCLUSION: Longer rooming wait times and longer ED visits were associated with increased SUD treatment referral interest. This suggests patients who wait for longer periods may be motivated for treatment and warrant further resource investment. [ABSTRACT FROM AUTHOR]

Rapamycin, an inhibitor of the mechanistic target of rapamycin (m TOR), robustly extends the lifespan of model organisms including mice. We recently found that chronic treatment with rapamycin not only inhibits m TOR complex 1 (m TORC1), the canonical target of rapamycin, but also inhibits m TOR complex 2 (m TORC2) in vivo. While genetic evidence strongly suggests that inhibition of m TORC1 is sufficient to promote longevity, the impact of m TORC2 inhibition on mammalian longevity has not been assessed. RICTOR is a protein component of m TORC2 that is essential for its activity. We examined three different mouse models of Rictor loss: mice heterozygous for Rictor, mice lacking hepatic Rictor, and mice in which Rictor was inducibly deleted throughout the body in adult animals. Surprisingly, we find that depletion of RICTOR significantly decreases male, but not female, lifespan. While the mechanism by which RICTOR loss impairs male survival remains obscure, we find that the effect of RICTOR depletion on lifespan is independent of the role of hepatic m TORC2 in promoting glucose tolerance. Our results suggest that inhibition of m TORC2 signaling is detrimental to males, which may explain in part why interventions that decrease m TOR signaling show greater efficacy in females. [ABSTRACT FROM AUTHOR]