168 results on '"G. Choe"'
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2. Characteristics of solar energy radiation on typical summer and winter days in Kuwait
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Shaharin Anwar Sulaiman, G. Choe, T. Saeed, D. Han, S. Marafie, and Mohammed A. Bou-Rabee
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Pyranometer ,Meteorology ,business.industry ,Mechanical Engineering ,Irradiance ,Radiation ,Solar energy ,Electric power system ,Electricity generation ,Automotive Engineering ,Environmental science ,Electric power ,business ,Solar power - Abstract
The energy received by solar collectors for power generation is limited to various conditions. The average data on solar irradiation are normally used to determine the potential of solar energy at any location. However, the variation of solar energy due to seasonal differences could affect the actual performance of the collectors, consequently leading to poorly justified system installations, which are high in cost. In this work, the characteristics of solar energy radiation in Kuwait were studied by measuring irradiance and comparing the data of selected time periods in two extreme seasons. A pyranometer, mounted two meters above the ground on a tubular beam in a shade-free area at a solar energy laboratory in Kuwait was used to measure irradiance on three consecutive days in summer and winter. The radiation data were recorded at five-minute intervals in each season for comparison. It was found that the average irradiance energy in the winter was up to 61% less than in the summer. In addition, the study revealed that the day-to-day variation of irradiance in winter (31%) was approximately 6.5 times higher than in the summer (4.8%). Clearly, the operation of solar power generation systems in the area during winter would face significant day-to-day fluctuations. As a result, this would necessitate frequent operation of backup power systems in order to meet the electrical power load demand.
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- 2015
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3. Clinicopathological and prognostic significance of programmed death ligand 1 expression in Korean melanoma patients
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Kwangha Lee, Kyu-Bo Lee, Hye Seung Lee, Seok Joong Yun, Young Joo Park, Sung Ho Moon, and G. Choe
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business.industry ,Melanoma ,Hematology ,medicine.disease ,Ligand (biochemistry) ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,Oncology ,030220 oncology & carcinogenesis ,Cancer research ,Medicine ,business ,Programmed death - Published
- 2018
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4. Immune modulatory effects of ibrutinib in pancreatic ductal adenocarcinoma
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M. Griffith, E Liu, Meenal Sinha, J. Sudduth-Klinger, G. Choe, Alexander Cheung, Shamilene Sivagnanam, Lisa M. Coussens, Lawrence Fong, Courtney Betts, Gina M. Vaccaro, Charles D. Lopez, W. Tamaki, and Margaret A. Tempero
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chemistry.chemical_compound ,Immune system ,Pancreatic ductal adenocarcinoma ,Oncology ,chemistry ,business.industry ,Ibrutinib ,Cancer research ,Medicine ,Hematology ,business - Published
- 2019
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5. Preconditioning, write width, and recording properties of Co-Cr-Pt-O perpendicular media with various underlayer designs
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B.R. Acharya, E.N. Abarra, M. Zheng, P. Gill, J.N. Zhou, and G. Choe
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Materials science ,Nuclear magnetic resonance ,Nanostructured materials ,Platinum compounds ,Analytical chemistry ,Cobalt compounds ,Perpendicular media ,Electrical and Electronic Engineering ,Electronic, Optical and Magnetic Materials - Abstract
The effect of magnetic "preconditioning" on the recording performance of perpendicular media is investigated. Furthermore, the dependence of the magnetic write width (MWW) of shielded-pole heads (SPH) on soft-underlayer (SUL) type and thickness (t/sub SUL/) and the recording performance of perpendicular media with thin SULs are examined. The MWW dependence on SUL structure is influenced by the pole-to-trailing shield spacing. For a wide-gap (/spl sim/80 nm) SPH, thick single-layer, SULs are preferred. For a narrow-gap (/spl sim/50 nm) SPH, MWW is less sensitive to the SUL type. For both narrow and wide-gap SPH and for media with an antiferromagnetically-coupled SUL, MWW is reduced for t/sub SUL/
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- 2005
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6. Highly in-plane oriented CoCrPtB longitudinal media for 130-Gb/in/sup 2/ recording
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B. Demczyk, F. Liu, J.N. Zhou, R. Weng, K.E. Johnson, K. Stoev, A. Chekanov, M. Yu, G. Choe, and M. Zheng
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Materials science ,business.industry ,Surface finish ,Microstructure ,Noise (electronics) ,Grain size ,Electronic, Optical and Magnetic Materials ,Magnetic anisotropy ,Nuclear magnetic resonance ,Particle-size distribution ,Optoelectronics ,Area density ,Texture (crystalline) ,Electrical and Electronic Engineering ,business - Abstract
A recording density of 130 Gb/in/sup 2/ was achieved using thermally stable conventional CoCrPtB longitudinal media. The high in-plane orientation ratio (OR) of the media resulted in an excellent recording performance due to a narrow switching field distribution as well as a high thermal stability caused by narrow energy barrier distribution. The low noise is attributed to the fully isolated fine grains with a narrow size distribution. A good in-plane c axis crystallographic texture was achieved by using an optimum multilayered structure of underlayer and magnetic layers. A detailed study of high OR media is reported by characterizing the magnetic, microstructural, and read/write properties.
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- 2003
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7. Quantitative analysis of retinal glycerolipid molecular species acetylated by acetolysis.
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H G Choe, R D Wiegand, and R E Anderson
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Biochemistry ,QD415-436 - Abstract
A method for the quantitative analysis of molecular species of 1,2-diacylglycerol acetates (1,2-DGAC) containing polyunsaturated fatty acids is described. Phosphatidylethanolamine (PE) isolated from frog retina was used to test the method. PE was converted to 1,2-DGAC by acetolysis. The molecular species of the 1,2-DGAC were resolved by reverse-phase high performance liquid chromatography (HPLC), detected by UV absorption spectroscopy at 210 nm, and identified by gas-liquid chromatography (GLC) of the fatty acid methyl esters (FAME). Molar response curves were generated for each DGAC molecular species that eluted as a single entity from HPLC by determining the moles of fatty acids in the molecular species collected and the response (peak area unit) of the UV detector. Each molecular species response curve was linear from about 10 pmoles to 4-8 nmoles, allowing the slope of each curve to be used as a molar absorptivity. This method provides a means for quantification of most of the molecular species of all glycerolipid classes.
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- 1989
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8. Perpendicular Recording Media Imaging Using Dynamic Read-Back Microscopy
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G. Choe, E.N. Abarra, and A.S. Chekanov
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Materials science ,Low oxygen ,business.industry ,Perpendicular recording ,Coercivity ,Electronic, Optical and Magnetic Materials ,Optics ,Nuclear magnetic resonance ,High oxygen ,Magnetic imaging ,Microscopy ,Erasure ,Electrical and Electronic Engineering ,business - Abstract
Magnetic patterns on perpendicular recording media were imaged by spin-stand level dynamic read-back microscopy. High-density tracks are clearly resolved up to 1000 kfci and details of magnetic bit structure, not usually observable using standard read-write tests, are readily observed. Encroachment of tracks on Co-Cr-Pt-O media with low oxygen content and low-coercivity results in a nonuniform erasure; as-written rectangular bits become trapezoidal in shape. Media with high oxygen content and high coercivity provide superior side erasure resistance
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- 2006
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9. Perpendicular recording CoPtCrO composite media with performance enhancement capping layer
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G. Choe, B.R. Acharya, J.N. Zhou, M. Zheng, and E.N. Abarra
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Fabrication ,Materials science ,Magnetoresistance ,business.industry ,Perpendicular recording ,Noise (electronics) ,Electronic, Optical and Magnetic Materials ,Magnetic anisotropy ,Nuclear magnetic resonance ,Optoelectronics ,Grain boundary ,Thermal stability ,Electrical and Electronic Engineering ,business ,Layer (electronics) - Abstract
A systematic investigation of the structural and recording characteristics of CoPtCrO composite media with various Co alloys as well as continuous TbFeCo capping layers has been performed. For the media with a Co-alloy capping layer (M/sub s//spl sim/900 emu/cm/sup 3/), the transition jitter remains unaffected and dc noise is greatly reduced. However, for the media with low M/sub s/ capping layer or continuously exchange coupled TbFeCo capping layer, transition jitter is increased. Magnetically continuous but structurally discontinuous Co-alloy capping layers grown onto well-isolated Co grains can reduce dc noise, while maintaining low transition noise.
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- 2005
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10. Anisotropy enhanced dual magnetic layer media design for high-density perpendicular recording
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M. Zheng, E.N. Abarra, Mingjun Yu, B.R. Acharya, G. Choe, and P. Gill
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Materials science ,Field (physics) ,business.industry ,Nucleation ,Perpendicular recording ,Electronic, Optical and Magnetic Materials ,Magnetic anisotropy ,Optics ,Optoelectronics ,Erasure ,Electrical and Electronic Engineering ,Thin film ,business ,Anisotropy ,Layer (electronics) - Abstract
An anisotropy enhanced dual magnetic layer structure is proposed to improve the recording performance of perpendicular media. The initial layer is made of low noise Co-Cr-Pt-O layer and the top layer is made of higher anisotropy Co-Cr-Pt-B layer. A higher nucleation field than the single layer structures is obtained for the dual magnetic layer media. By optimizing the layer structure and properties, better signal-to-noise and lower adjacent track erasure can be achieved for the dual magnetic layer design over single magnetic layer media.
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- 2005
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11. Effect of soft underlayer permeability on wide area track erasure in perpendicular recording
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M. Zheng, E.N. Abarra, J.N. Zhou, G. Choe, P. Gill, and B.R. Acharya
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Materials science ,Nuclear magnetic resonance ,Wide area ,Permeability (electromagnetism) ,Perpendicular recording ,Erasure ,Electrical and Electronic Engineering ,Composite material ,Finite thickness ,Antiferromagnetic coupling ,Electronic, Optical and Magnetic Materials - Abstract
The permeability of the magnetic soft underlayer (SUL) was systematically varied through SUL structure change, and its effect on wide area adjacent track erasure (ATE) and media overwrite (OW) was studied. Results suggest that ATE decreases with SUL permeability, and it involves only a finite thickness of the SUL. OW increases with SUL permeability as well as SUL thickness. In addition, ATE is less affected by magnetic spacing than OW. Antiparallel coupled SUL (APS) improves ATE. A double-APS structure with a permeability gradient is proposed to optimize OW and ATE performance.
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- 2005
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12. Bulk AC-erasure technique for perpendicular recording media: effect of exchange coupling
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B.R. Acharya, E.N. Abarra, B.G. Demczyk, P. Gill, G. Choe, J.N. Zhou, and M. Zheng
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Coupling ,Materials science ,Condensed matter physics ,Perpendicular recording ,Astrophysics::Cosmology and Extragalactic Astrophysics ,Electronic, Optical and Magnetic Materials ,Background noise ,Nuclear magnetic resonance ,Magnet ,Perpendicular ,Electrical and Electronic Engineering ,Magnetic force microscope ,Anisotropy ,Astrophysics::Galaxy Astrophysics ,Noise (radio) - Abstract
We discuss a method of ac-demagnetizing an entire disk using permanent magnets and compare the demagnetized states of perpendicular media with different levels of intergranular exchange. The method consists of applying a large field perpendicular to the media recording layer anisotropy direction. This bulk ac-erasure technique provides a background noise that is lower than that which can be achieved by ac-erasing with a write head. Highly exchange-coupled media exhibit low dc noise but increased ac-erased background noise. Magnetic force microscopy data show increased magnetic roughness in the ac-erased state with exchange-coupling strength. For the media with least coupling the dc noise is similar to the ac noise.
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- 2005
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13. Compositionally Graded Magnetic Multilayer Films for High Areal Density Longitudinal Recording
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B.R. Acharya, J.N. Zhou, G. Choe, E.N. Abarra, M. Yu, and K.E. Johnson
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Materials science ,business.industry ,Noise (electronics) ,Electronic, Optical and Magnetic Materials ,Magnetic anisotropy ,Nuclear magnetic resonance ,Signal-to-noise ratio (imaging) ,Volume (thermodynamics) ,Optoelectronics ,Thermal stability ,Area density ,Texture (crystalline) ,Electrical and Electronic Engineering ,business ,High-κ dielectric - Abstract
Compositionally graded magnetic multilayer (CGM) structures were investigated to improve media signal-to-noise ratio (SNR) as well as thermal stability. The medium structure consists of multiple magnetic layers that play an important role in determining the crystallographic texture as well as magnetic activation volume. Low medium noise is achieved while retaining high resolution, as the number of layers is increased. The CGM media offer a magnetic anisotropy gradient from the top to bottom layers, which enhances head writability at high frequencies without affecting thermal stability. Improved magnetic and recording properties such as high K/sub u/ V/kT, SNR, and overwrite are obtained with CGM media, suitable for high areal density recording.
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- 2004
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14. Anti-Parallel Coupled Soft Under Layers for High-Density Perpendicular Recording
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E.N. Abarra, M. Zheng, J.N. Zhou, B.R. Acharya, K.E. Johnson, and G. Choe
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Materials science ,business.industry ,Nucleation ,Magnetic separation ,Perpendicular recording ,Coercivity ,Electronic, Optical and Magnetic Materials ,Magnetic anisotropy ,Nuclear magnetic resonance ,Permeability (electromagnetism) ,Optoelectronics ,Erasure ,Recording media ,Electrical and Electronic Engineering ,business - Abstract
A promising soft magnetic under layer (SUL) structure consisting of anti-parallel coupled soft layers (APS) is investigated to improve the performance of high-density perpendicular recording media. CoCrPt-O recording media with average grain diameter /spl sim/6 nm, coercivity of 5 kOe and nucleation field of -2 kOe is fabricated on both conventional SUL and APS. Wide-area adjacent track erasure (ATE) is observed for conventional SUL, which increases at lower interlayer spacing (t/sub IL/). APS structure enables the suppression of ATE even up to t/sub IL/=10 nm. Moreover, APS leads to reduced dc erase noise and improved signal to noise ratio particularly for SUL thicknesses
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- 2004
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15. Role of Oxygen Incorporation in Co-Cr-Pt-Si-O Perpendicular Magnetic Recording Media
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Z.D. Yang, G. Choe, K.E. Johnson, M. Zheng, J.N. Zhou, E.N. Abarra, and B.R. Acharya
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Materials science ,Oxide ,Analytical chemistry ,Perpendicular recording ,chemistry.chemical_element ,Coercivity ,Sputter deposition ,Oxygen ,Electronic, Optical and Magnetic Materials ,chemistry.chemical_compound ,Magnetization ,Nuclear magnetic resonance ,X-ray photoelectron spectroscopy ,chemistry ,Grain boundary ,Electrical and Electronic Engineering - Abstract
The effect of oxygen incorporation on the crystallographic, magnetic, and recording performance of perpendicular magnetic recording (PMR) oxide media was investigated. The media were prepared by dc-magnetron sputtering of CoCrPt-SiO/sub 2/ targets in an Ar/O/sub 2/ gas mixture. X-ray photoelectron spectroscopy (XPS) detected Cr-O peaks in the sputtered film, whereas no strong evidence of SiO/sub 2/ is seen. Moderate oxygen incorporation in the film (/spl sim/15 at%) promotes Cr-O formation in the grain boundary and results in a dramatic increase of coercivity H/sub c/ and signal-to-noise ratio (SNR). However, as the O/sub 2/ content is further increased, oxide incorporates into the core of the grains, resulting in decreased H/sub c/, magnetization and SNR.
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- 2004
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16. Performance Comparison Between Conventional and AFC Media at Different Orientation Ratios
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G. Choe, J. Gao, J.N. Zhou, K.E. Johnson, B.R. Acharya, and E.N. Abarra
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Nuclear magnetic resonance ,Materials science ,Performance comparison ,Orientation (geometry) ,Isotropy ,Analytical chemistry ,Thermal stability ,Electrical and Electronic Engineering ,Thermal decay ,Electronic, Optical and Magnetic Materials - Abstract
Antiferromagnetically coupled (AFC) media and conventional media (CM) were compared side to side over a wide range of orientation ratios (OR). For both AFC and CM, oriented media outperform isotropic media. AFC and CM show similar signal-to-noise ratios (SNR) throughout the entire range of OR. CM exhibit good SNR performance even at M/sub r/t
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- 2004
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17. Transition and DC noise characteristics of longitudinal oriented media
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Kyung Jin Lee, G. Choe, K.E. Johnson, and B.R. Acharya
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Nuclear magnetic resonance ,Materials science ,Signal-to-noise ratio ,Condensed matter physics ,Magnetic noise ,Area density ,Recording media ,Electrical and Electronic Engineering ,Transition noise ,Grain orientation ,Noise (radio) ,Electronic, Optical and Magnetic Materials ,Magnetic transitions - Abstract
Transition and DC noise characteristics of longitudinal recording media were studied as a function of orientation ratio (OR). With increasing OR, a substantial decrease of DC noise is observed against the gradually increasing transition noise, resulting in the reduced media total noise. The increase in the media transition noise with OR is attributed to the increase in the cross-track correlation length s. The experimentally estimated s for the media with OR=1.8 is significantly larger than that of the media with OR=1.25, possibly resulting from the difference in magnetostatically coupled Co grains aligned to the track direction. For high-density low M/sub r/t designs, reducing DC noise by increasing OR, in spite of an increase in transition noise, becomes an effective means to increasing areal density.
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- 2003
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18. High-density longitudinal recording media with CrMoB underlayer
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B.R. Acharya, Mingjun Yu, and G. Choe
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Materials science ,Recording density ,Signal-to-noise ratio ,Perpendicular recording ,High density ,Recording media ,Electrical and Electronic Engineering ,Coercivity ,Composite material ,Microstructure ,Grain size ,Electronic, Optical and Magnetic Materials - Abstract
The structural, magnetic, and recording properties of longitudinal recording media with CrMoB underlayer were studied and compared to those with CrMo underlayer. Media with CrMoB underlayer have smaller grain size, better grain segregation, lower coercivity, and better recording performance than media with CrMo underlayer.
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- 2003
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19. Recording characteristics of perpendicular magnetic media with CoZrNb, NiFeNb, and exchange-pinned NiFeNb soft magnetic underlayers
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L. Gao, Sy_Hwang Liou, Kenneth E. Johnson, Albert Chekanov, Min Zheng, and G. Choe
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Magnetic anisotropy ,Materials science ,Nuclear magnetic resonance ,Condensed matter physics ,Magnetic media ,Permeability (electromagnetism) ,Perpendicular ,General Physics and Astronomy ,Frequency dependence ,Coercivity ,Nanocrystalline material ,Amorphous solid - Abstract
The recording performance of perpendicular media with amorphous CoZrNb, nanocrystalline NiFeNb, and exchange-pinned FeMn/NiFeNb soft magnetic underlayers (SULs) has been studied. A method has been proposed to quantify the spike noises from the SUL. We found that media with higher permeability NiFeNb SULs showed 4 db higher signal-to-noise ratio than media with lower permeability CoZrNb SULs. The exchange-pinned NiFeNb SUL suppresses spike noise and offers good recording performance. Furthermore, the recording frequency dependence of dynamic coercivity (Hc) was strongly affected by the use of different SULs. The increase in dynamic Hc with linear density is negligibly small for media with NiFeNb SULs, whereas dynamic Hc sharply increases with increasing density for media with CoZrNb SULs.
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- 2003
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20. Effect of crystallographic orientation dispersion on media thermal stability and recording characteristics
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G. Choe, M. Zheng, K.E. Johnson, and Kyung Jin Lee
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Materials science ,Condensed matter physics ,business.industry ,Coercivity ,Electronic, Optical and Magnetic Materials ,Magnetic anisotropy ,Optics ,Dispersion (optics) ,Thermal stability ,Texture (crystalline) ,Electrical and Electronic Engineering ,Thin film ,Anisotropy ,business ,Noise (radio) - Abstract
We have studied thermal stability and recording characteristics of CoCrPtB alloy media with varying c axis anisotropy dispersion, preferred orientation (PO), and in-plane orientation ratio (OR) on both glass and NiP-plated Al substrates. With increasing in-plane c axis orientation and OR, improved recording performances such as lower pulsewidth, lower media transition noise, and lower dc noise are achieved. Thermal decay rate is primarily determined by Co anisotropy dispersion and in-plane OR for the same coercivity media. Media having a large out-of-plane c axis component exhibit a wide switching field distribution and have a high signal decay rate. The PW/sub 50/ and dc noise of media with out-of-plane Co grains are very sensitive to changes in write field. On the other hand, highly oriented media having high OR are less sensitive to head writability variations and offer good thermal stability with excellent recording performance.
- Published
- 2002
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21. Seedlayer and preheating effects on crystallography and recording performance of CoCrPtB perpendicular media
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Sy_Hwang Liou, Kenneth E. Johnson, G. Choe, Lan Gao, and Min Zheng
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Crystallography ,Materials science ,Sputtering ,Annealing (metallurgy) ,Perpendicular recording ,Thermal stability ,Electrical and Electronic Engineering ,Thin film ,Magnetic force microscope ,Coercivity ,Magnetic hysteresis ,Electronic, Optical and Magnetic Materials - Abstract
Summary form only given. Perpendicular magnetic recording (PMR) media has been considered as a promising candidate in order to achieve over 100 Gbir/in2 recording density. However, thermal stability at low recording densities has been a concern especially for low-noise PMR media. Achieving high perpendicular HC and unity squareness (SQ=Mr/Ms) is necessary to improve thermal stability and has been proposed by using either high substrate temperature or post annealing in CoCr based alloy. However, the influence of high heating on recording performance deserves further investigation. In this work, we studied on the seedlayer and heating effects on the crystallographic, magnetic and recording properties of CoCr18Pt16B4 granular PMR media. The CoCrPtB films were sputtered on preheated glass substrates with a Ru underlayer (UL) or a Ta/Ru UL on top of a 300-nm-thick NiFe17Mo4 soft magnetic underlayer. We report that Ta/Ru UL developed in this study greatly enhances Ru(0002)/Co(0002) crystallography, HC, SQ and thermal stability without degrading media signal-to-noise ratio (So/Nm).
- Published
- 2002
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22. Effect of stress induced anisotropy on SAL-biased MR head performance
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E. Johns, A. Wu, G. Choe, and F. Gocemen
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Stress (mechanics) ,Physics ,Recording head ,Magnetic anisotropy ,Amplitude ,Nuclear magnetic resonance ,Condensed matter physics ,Magnetoresistance ,Magnetostriction ,Electrical and Electronic Engineering ,Anisotropy ,Magnetostatics ,Electronic, Optical and Magnetic Materials - Abstract
The effect of magnetostriction (MS) on the device characteristics of soft-adjacent-layer (SAL) biased magnetoresistive (MR) head was investigated. As MS changes from -7/spl times/10/sup -7/ to 1.77/spl times/10/sup -6/, the magnetic track width increases from 1.26 to 1.83 /spl mu/m. Asymmetry of bias point, output sensitivity, and output amplitude are also affected by the stress induced anisotropy. The variation of magnetostriction (/spl Delta//spl lambda/=2/spl times/10/sup -6/) induces the change in bias field by 60 Oe associated with the estimated stress of +800 MPa on the MR stripe.
- Published
- 1999
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23. High precision magnetostriction measurement employing the B-H looper bending method
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B. Megdal and G. Choe
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Permalloy ,Magnetic anisotropy ,Materials science ,Nuclear magnetic resonance ,Analytical chemistry ,Sigma ,Magnetostriction ,Bending ,Repeatability ,Electrical and Electronic Engineering ,Lambda ,Magnetic hysteresis ,Electronic, Optical and Magnetic Materials - Abstract
We report a simple, nondestructive B-H looper bending method for measuring 10/sup -7/ of magnetostriction (/spl lambda/) in thin films (/spl sim/150 /spl Aring/). The new method improves the accuracy and repeatability of /spl Delta/H/sub k/ measurements in loopers by employing a measurement sequence that corrects the non-repeatable balance errors. For the 150 /spl Aring/ thick NiFe films under an anisotropic strain of 4.6/spl times/10/sup -5/, we achieved a /spl Delta/H/sub k/ repeatability, 1/spl sigma/=0.009 Oe which is equivalent to 3.4/spl times/10/sup -8/ in /spl lambda/. Our technique gives /spl lambda/ values that agree well with the optical cantilever bending technique and can be easily utilized in a thin-film head production environment for accurate control of /spl lambda/.
- Published
- 1999
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24. Giant interface magnetostriction and temperature dependence in NiFe films encapsulated with Ta and Al/sub 2/O/sub 3/ layers
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G. Choe
- Subjects
Materials science ,Annealing (metallurgy) ,Tantalum ,Analytical chemistry ,chemistry.chemical_element ,Magnetostriction ,Giant magnetoresistance ,Electronic, Optical and Magnetic Materials ,Magnetic anisotropy ,Nuclear magnetic resonance ,Ferromagnetism ,chemistry ,Electrical and Electronic Engineering ,Thin film ,Anisotropy - Abstract
The interface magnetostriction (MS), /spl lambda//sub i/ of NiFe films (thicknesses:50 to 500 /spl Aring/) encapsulated with Ta and Al/sub 2/O/sub 3/ layers was studied in as-deposited and thermally annealed states. The MS of NiFe films encapsulated with only Ta (or Al/sub 2/O/sub 3/) layers increase (or decrease) rapidly with decreasing NiFe thickness, due to giant positive (or negative) /spl lambda//sub i/. The magnitudes of both positive and negative /spl lambda//sub i/ increase noticeably with processing at elevated temperatures. In structures containing Ta/NiFe and NiFe/Al/sub 2/O/sub 3/ interfaces, the total interfacial MS contribution is greatly reduced due to the opposite signs of /spl lambda//sub i/ at NiFe interfaces, leading to negligible thickness dependence of the effective MS in as-deposited and annealed states. The strong interfacial MS induced anisotropy affects markedly the uniaxial anisotropy of NiFe films for thicknesses below 100 /spl Aring/.
- Published
- 1999
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25. Growth of giant magnetoresistive spin valves with strong exchange bias field
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G. Choe, A. Tsoukatos, and Subhadra Gupta
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Exchange bias ,Materials science ,Transition metal ,Magnetoresistance ,Condensed matter physics ,Giant magnetoresistance ,Substrate (electronics) ,Surface finish ,Texture (crystalline) ,Electrical and Electronic Engineering ,Thin film ,Electronic, Optical and Magnetic Materials - Abstract
FeMn based spin valves exhibiting high GMR ratio and high exchange bias field were fabricated by improving the interface roughness as well as the crystallographic texture. A highly oriented (111) NiFe free layer deposited with substrate bias promoted strong (111) textures of Cu and FeMn while maintaining sharp interfaces, resulting in a high exchange bias field, a high blocking temperature, and a high GMR ratio. The correlation between the interlayer coupling energy (J/sub free-pinned/) and the interface sharpness was studied as a function of Cu spacer thickness for spin valves with free and pinned NiFe layers deposited under various bias conditions.
- Published
- 1998
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26. Magnetic Force Microscopy Study of CoPtCrO Perpendicular Media With Superparamagnetic And Permanent Magnet Tips
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L. Gao, S.S. Malhotra, L. Yuan, B. Han, M. Zheng, E.N. Abarra, Sy_Hwang Liou, G. Choe, B.R. Acharya, and Leighann Nicholl
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Materials science ,Condensed matter physics ,Magnetic domain ,Magnet ,Perpendicular ,High density ,Perpendicular media ,Recording media ,Magnetic force microscope ,Superparamagnetism - Abstract
This paper compares the images obtained by superparamagnetic and permanent magnetic force microscopy (MFM) tips, that allows us to explain the issues related to the frequency double in some of domain images of the recording media. This paper also investigates the domain structures of high density recording bits (up to 1100 kfci) written on ac and dc-erased CoPtCrO perpendicular magnetic recording (PMR) media with permanent magnet MFM tips under ambient conditions.
- Published
- 2006
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27. NiFe underlayer effects on exchange coupling field and coercivity in NiFe/FeMn films
- Author
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Subhadra Gupta and G. Choe
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Magnetic anisotropy ,Materials science ,Exchange bias ,Ferromagnetism ,Condensed matter physics ,Magnetoresistance ,Substrate (electronics) ,Texture (crystalline) ,Electrical and Electronic Engineering ,Coercivity ,Grain size ,Electronic, Optical and Magnetic Materials - Abstract
The effect of NiFe texture on the exchange coupling field and coercivity of Ta/NiFe/FeMn films was studied by varying the deposition conditions of dc magnetron-sputtered NiFe films. By decreasing argon pressure or by increasing substrate bias, strongly textured, large grains of NiFe(111) were grown, yielding highly oriented FeMn(111) texture. Well oriented NiFe(111)/FeMn(111) films yielded the highest exchange anisotropy (0.14 erg/cm/sup 2/), lowest coercivity (/spl ap/2 Oe), and highest blocking temperature (200/spl deg/C) ever reported.
- Published
- 1997
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28. Magnetic properties of sequentially sputtered amorphous Fe-Ge thin films
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A.P. Valanju, G. Choe, and R.M. Walser
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Carbon film ,Materials science ,Annealing (metallurgy) ,Sputtering ,Analytical chemistry ,Chemical vapor deposition ,Electrical and Electronic Engineering ,Sputter deposition ,Thin film ,Nanoscopic scale ,Electronic, Optical and Magnetic Materials ,Amorphous solid - Abstract
Fe/sub x/Ge/sub 100-x/ films with compositions in the range 50/spl les/x/spl les/82 at 300 K were deposited by rf diode, sequential sputtering from elemental targets. All the films were amorphous at 300 K indicating that the Fe concentration in the stable amorphous films was increased by more than 10 at. % over that obtained by vapor deposition. The sequentially sputtered Fe-Ge films exhibited a heteroamorphous morphology with nanoscale features that varied with composition. The variations in the 4/spl pi/M/sub s/ and T/sub c/ for the sputtered Fe rich films, agreed well with data extrapolated from measurements on Ge rich evaporated films. The improvement in the soft magnetic properties produced in these films by rotating magnetic field annealing (RFA) was shown to be correlated with changes in film morphology.
- Published
- 1996
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29. Effect of film morphology on grain boundary segregation induced magnetic properties in heat treated CoCrPt/Cr films
- Author
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G. Choe
- Subjects
Materials science ,Sputtering ,Transmission electron microscopy ,Annealing (metallurgy) ,Physical vapor deposition ,Grain boundary ,Electrical and Electronic Engineering ,Thin film ,Intergranular corrosion ,Composite material ,Grain size ,Electronic, Optical and Magnetic Materials - Abstract
Effect of Co grain morphology on Cr segregation induced magnetic properties was investigated in heat treated CoCrPt/Cr thin films. In this work, interdiffusion and Cr segregation induced Co grain isolation were studied by post-deposition annealing of the CoCrPt films deposited on a Cr underlayer at different sputtering conditions. The films with voided boundaries showed a stronger heating temperature dependence of magnetic properties than the dense films, due to the promoted Cr segregation at the boundaries. TEM observation indicated that Cr was segregated from the Cr underlayer to the void boundaries of the CoCrPt films. The grain morphology of as-deposited films played an important role in Cr segregation during heat treatment, and the intergranular exchange decoupling was enhanced by the diffusion of Cr atoms into the voids isolating the Co grains.
- Published
- 1995
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30. Measurement of very low magnetostrictions in thin films
- Author
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B. H. Lee, S. Rengarajan, R.M. Walser, and G. Choe
- Subjects
Materials science ,Cantilever ,Dynamic range ,business.industry ,Resolution (electron density) ,Magnetostriction ,Electronic, Optical and Magnetic Materials ,Optics ,Astronomical interferometer ,Calibration ,Electrical and Electronic Engineering ,Magnetic alloy ,Thin film ,business - Abstract
A highly sensitive optical interferometer with in-situ calibration was developed to measure the low-field magnetostriction of magnetic thin films using the cantilever beam technique, The high displacement resolution (0.01 /spl Aring/) of this instrument permits the measurement of magnetostrictions of 10/sup -9/. First measurements on a soft CoFeSiB thin film were made to demonstrate this technique. The magnetostriction measurement resolution of 5/spl times/10 obtained is the lowest yet reported value. The dynamic range of the technique was demonstrated in measurements of a magnetostriction greater than 10/sup -5/.
- Published
- 1995
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31. The structure and magnetic properties of sputtered, amorphous CoFeSiB thin films
- Author
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R.M. Walser, Byung-Il Cho, R. Banerjee, and G. Choe
- Subjects
Magnetic anisotropy ,Materials science ,Ferromagnetism ,Annealing (metallurgy) ,Sputtering ,Magnetostriction ,Electrical and Electronic Engineering ,Coercivity ,Thin film ,Composite material ,Electronic, Optical and Magnetic Materials ,Amorphous solid - Abstract
Amorphous wires and ribbons of composition Co/sub 70.5/Fe/sub 4.5/Si/sub 15/B/sub 10/ have a very small magnetostriction and very low coercivities for wall motion. Their high permeabilities are of considerable technological interest. Thin films of these alloys might be useful for applications, but had not been previously studied. This work studied the structural and magnetic properties of amorphous thin films sputtered from an alloy target with the composition Co/sub 70.5/Fe/sub 4.5/Si/sub 15/B/sub 10/. The results obtained show that the coercivity and in-plane anisotropy of the sputtered films are much larger than those of ribbons and wires. Attempts to reduce these parameters by varying the processing and annealing parameters, substrate material, composition, and film thickness were largely unsuccessful. While these results are not understood, the composite data suggests that the higher values may be due to micro-compositional inhomogeneities resulting from higher effective quench rates of sputtering.
- Published
- 1995
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32. Exchange anisotropy in reactively sputtered amorphous CoFeSiB:O thin films
- Author
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G. Choe, R.M. Walser, R. Banerjee, and W. Win
- Subjects
Magnetic anisotropy ,Nuclear magnetic resonance ,Exchange bias ,Materials science ,Ferromagnetism ,Sputtering ,Analytical chemistry ,Electrical and Electronic Engineering ,Thin film ,Coercivity ,Magnetic hysteresis ,Electronic, Optical and Magnetic Materials ,Amorphous solid - Abstract
Exchange-shifted hysteresis loops were observed at 300 K in thin amorphous films deposited from a CoFeSiB alloy target by reactive oxygen sputtering. The heterogeneous film morphologies consisted of nanoscale features with thin, apparently oxidized, boundaries, The exchange shift varied with the film thickness, and with the ratio of the oxygen to argon gas flow, The CoFeSiB:O films exhibiting exchange anisotropy had resistivities in the range /spl sim/10/sup 3/ /spl mu//spl Omega//spl middot/cm to /spl sim/10/sup 4/ /spl mu//spl Omega//spl middot/cm. The maximum shift (/spl sim/10 Oe) was observed in films with a resistivity of /spl sim/2500 /spl mu//spl Omega//spl middot/cm. The exchange anisotropy appears to be due to coupling between nanoscale regions with different coercivities.
- Published
- 1995
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33. Establishment and characterization of nine human brain tumor cell lines
- Author
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K H, Shin, G, Choe, Y J, Park, J H, Jang, H W, Jung, and J G, Park
- Subjects
Brain Neoplasms ,Tumor Suppressor Proteins ,Oligodendroglioma ,PTEN Phosphohydrolase ,Brain ,Neuroectodermal Tumors ,Phosphoric Monoester Hydrolases ,Acid Anhydride Hydrolases ,Neoplasm Proteins ,Astrocytes ,Glial Fibrillary Acidic Protein ,Tumor Cells, Cultured ,Humans ,Genes, Tumor Suppressor ,Tumor Suppressor Protein p53 ,Glioblastoma ,Biomarkers ,Cyclin-Dependent Kinase Inhibitor p16 - Published
- 2002
34. 534 Expression of c-MET in invasive meningioma
- Author
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G. Choe, K. Nam, Seok Joong Yun, J. Koh, Keun Wook Lee, and A. Seo
- Subjects
Meningioma ,Cancer Research ,chemistry.chemical_compound ,C-Met ,Oncology ,chemistry ,business.industry ,Cancer research ,Medicine ,business ,medicine.disease - Published
- 2014
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35. Spinal intradural extramedullary capillary hemangioma: MR imaging findings
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B Y, Choi, K H, Chang, G, Choe, M H, Han, S W, Park, I K, Yu, Y H, Park, and H J, Kim
- Subjects
Adult ,Male ,Neurologic Examination ,Lumbar Vertebrae ,Middle Aged ,Thoracic Neoplasms ,Image Enhancement ,Magnetic Resonance Imaging ,Spine ,Diagnosis, Differential ,Spinal Cord ,Humans ,Hemangioma, Capillary ,Spinal Cord Neoplasms - Abstract
Summary: Spinal intradural extramedullary capillary hemangiomas are extremely rare. We present the MR imaging and histologic findings in three patients with this abnormality. The three patients were men who had symptoms of either myelopathy (n = 2) or radiculopathy (n = 1). The tumors were well demarcated, 1.5–2.0 cm in diameter, and were located at the posterior or posterolateral portion of the thecal sac (one at the L1 level and the other two at the midthoracic level). On MR images, the tumor showed isointensity relative to the spinal cord on T1-weighted images, hyperintensity on T2-weighted images, and strong homogeneous enhancement on contrast-enhanced T1-weighted images in all three patients. In two patients, the dural tail sign was observed. Capillary hemangioma should be included in the differential diagnosis of a spinal intradural extramedullary tumor.
- Published
- 2001
36. MR imaging features of clear-cell meningioma with diffuse leptomeningeal seeding
- Author
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W, Lee, K H, Chang, G, Choe, J G, Chi, C K, Chung, I H, Kim, M H, Han, S W, Park, S J, Shin, and Y H, Koh
- Subjects
Male ,Adolescent ,otorhinolaryngologic diseases ,Meningeal Neoplasms ,Humans ,Brain ,Neoplasms, Second Primary ,Arachnoid ,Meningioma ,neoplasms ,Magnetic Resonance Imaging ,nervous system diseases - Abstract
Summary: Clear-cell meningioma is a rare disease entity showing a more aggressive nature, clinically, than those of other subtypes of meningioma. It occurs in younger persons and commonly in the spinal canal. The recurrence rate has been reported to be as high as 60%. We present a case of clear-cell meningioma in a 17-year-old man in whom initial MR imaging showed localized leptomeningeal enhancement that had progressed into the entire subarachnoid space after surgical resection of the primary tumor.
- Published
- 2000
37. The Tsk2/+ Mouse Fibrotic Phenotype Is Due to a Gain-of-Function Mutation in the PIIINP Segment of the Col3a1 Gene
- Author
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Garth D. Ehrlich, Susanna G. Choe, Rory A. Eutsey, Kristen B. Long, Elizabeth P. Blankenhorn, Chelsea M. Burgwin, Josh Earl, Viktor Martyanov, Carol M. Artlett, Zhenghui Li, Azad Ahmed, Sihem Sassi-Gaha, and Michael L. Whitfield
- Subjects
Male ,Genotype ,Genetic Linkage ,Mutation, Missense ,Dermatology ,Biology ,Gene mutation ,Protein Serine-Threonine Kinases ,medicine.disease_cause ,Polymorphism, Single Nucleotide ,Biochemistry ,Article ,Extracellular matrix ,Mice ,Fibrosis ,medicine ,Missense mutation ,Animals ,Gene ,Molecular Biology ,Skin ,Mutation ,Scleroderma, Systemic ,integumentary system ,Point mutation ,Cell Biology ,medicine.disease ,Molecular biology ,Peptide Fragments ,Mice, Inbred C57BL ,Procollagen peptidase ,Disease Models, Animal ,Collagen Type III ,Phenotype ,Female ,Procollagen - Abstract
Systemic sclerosis (SSc) is a polygenic, autoimmune disorder of unknown etiology, characterized by the excessive accumulation of extracellular matrix (ECM) proteins, vascular alterations, and autoantibodies. The tight skin (Tsk)2/+ mouse model of SSc demonstrates signs similar to SSc including tight skin and excessive deposition of dermal ECM proteins. By linkage analysis, we mapped the Tsk2 gene mutation to
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38. Acupotomy combined with Korean medicine treatment in a patient with acute sacroiliac pain unresponsive to conventional therapy: A case report.
- Author
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Choe G and Hwang JH
- Subjects
- Humans, Male, Middle Aged, Medicine, Korean Traditional, Acute Pain therapy, Acute Pain drug therapy, Combined Modality Therapy, Sacroiliac Joint, Acupuncture Therapy methods
- Abstract
Rationale: Acute injury to the sacroiliac joint (SIJ) can result from high-energy external forces that cause a combination of axial loading and sudden rotational movements, resulting in severe pain that cannot be relieved by regular nonsteroidal anti-inflammatory drugs. The treatment includes injections of steroids and local anesthetics to reduce pain and promote healing. Here, we report the case of a patient with acute sacroiliac pain who did not respond to conventional injection therapy., Patient Concerns: A 58-year-old male patient who did not exercise regularly experienced pain in his left groin and difficulty walking while kicking on his right leg. He received two injections and manual therapy at a local orthopedic clinic; however, his symptoms did not improve despite taking painkillers., Diagnoses: Radiographic images showed no abnormalities. After confirming the cause of onset, pain pattern, physical examination, and tenderness, the patient was diagnosed with an acute SIJ sprain (static blood)., Interventions: At the first visit, a single acupotomy was performed on the seven treatment points identified during the physical examination, and immediate improvement in symptoms was confirmed. From then on, Korean medicine (KM) treatments, such as acupuncture, cupping, chuna, and bee venom pharmacopuncture, were performed., Outcomes: Immediately after acupotomy, groin pain improved by 80 %, gait immediately normalized, and the patient showed no symptoms at the 9th visit., Lessons: For SIJ-type groin pain that does not respond to existing treatments, immediate relief is achieved after a single acupotomy at the exact treatment point. Therefore, in the future, the importance of identifying a precise treatment point for SIJ pain should be recognized, and the use of Korean medicine treatment techniques, including acupotomy, should be considered., (Copyright © 2024. Published by Elsevier Inc.)
- Published
- 2024
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39. Comparative Effectiveness of Personal Sound Amplification Products Versus Hearing Aids for Unilateral Hearing Loss: A Prospective Randomized Crossover Trial.
- Author
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Kim MS, Kim KH, Choe G, and Park YH
- Subjects
- Humans, Male, Female, Middle Aged, Prospective Studies, Surveys and Questionnaires, Aged, Adult, Patient Satisfaction, Noise, Signal-To-Noise Ratio, Hearing Aids, Cross-Over Studies, Speech Perception, Hearing Loss, Unilateral rehabilitation
- Abstract
Background: This study compared hearing outcomes with use of personal sound amplification products (PSAPs) and hearing aids (HAs) in patients with moderate to moderately severe unilateral hearing loss., Methods: Thirty-nine participants were prospectively enrolled, and randomly assigned to use either one HA (basic or premium type) or one PSAP (basic or high-end type) for the first 8 weeks and then the other device for the following 8 weeks. Participants underwent a battery of examinations at three visits, including sound-field audiometry, word recognition score (WRS), speech perception in quiet and in noise, real-ear measurement, and self-report questionnaires., Results: Functional gain was significantly higher with HAs across all frequencies ( P < 0.001). While both PSAPs and HAs improved WRS from the unaided condition, HAs were superior to PSAPs. The speech recognition threshold in quiet conditions and signal-to-noise ratio in noisy conditions were significantly lower in the HA-aided condition than in the PSAP-aided condition, and in the PSAP-aided condition than in the unaided condition. Subjective satisfaction also favored HAs than PSAPs in questionnaires, Abbreviated Profile of Hearing Aid Benefit, International Outcome Inventory for Hearing Aids, and Host Institutional Questionnaire., Conclusion: While PSAPs provide some benefit for moderate to moderately severe unilateral hearing loss, HAs are more effective. This underscores the potential role of PSAPs as an accessible, affordable first-line intervention in hearing rehabilitation, particularly for individuals facing challenges in accessing conventional HAs., Competing Interests: The authors have no potential conflicts of interest to disclose., (© 2024 The Korean Academy of Medical Sciences.)
- Published
- 2024
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40. Exploring the potential of ex-vivo 7-T magnetic resonance imaging on patients with clinically significant prostate cancer: visibility and size perspective.
- Author
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Ahn H, Kim JK, Hwang SI, Hong SK, Byun SS, Song SH, Choe G, Jee HM, and Park SW
- Abstract
Background: Despite progress in multiparametric magnetic resonance imaging (MRI), issues of prostate cancer invisibility and underestimated tumor burden persist. This study investigates the potential of an ultra-high field MRI at 7-T in an ex-vivo setting to address these limitations., Methods: This prospective study included 54 tumors from 20 treatment-naïve clinically significant prostate cancer patients, confirmed by biopsy, despite negative findings on preoperative 3-T MRI. Ex-vivo 7-T MRI of resected prostates was performed, with assessment on tumor visibility and size. Factors influencing visibility were analyzed using logistic regression analyses., Results: Tumor visibility was confirmed in 80% of patients, and 48% of all tumors on ex-vivo imaging. Gleason pattern 4 percentage (odds ratio 1.09) and tumor size on pathology (odds ratio 1.36) were significantly associated with visibility ( P < 0.05). Mean MRI-visible and invisible tumor sizes were 10.5 mm and 5.3 mm, respectively. The size discrepancy between MRI and pathology was 2.7 mm., Conclusion: Tumor visibility on ex-vivo 7-T MRI was influenced by tumor grade and size. The notable tumor visibility initially overlooked on 3-T MRI, along with small size discrepancy with pathology, suggests potential improvements in resolution., (© 2024 The Asian Pacific Prostate Society. Published by Elsevier B.V.)
- Published
- 2024
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41. Strain-invariant stretchable radio-frequency electronics.
- Author
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Kim SH, Basir A, Avila R, Lim J, Hong SW, Choe G, Shin JH, Hwang JH, Park SY, Joo J, Lee C, Choi J, Lee B, Choi KS, Jung S, Kim TI, Yoo H, and Jung YH
- Subjects
- Humans, Monitoring, Physiologic instrumentation, Elasticity, Electronics instrumentation, Equipment Design, Radio Waves, Skin, Stress, Mechanical, Wearable Electronic Devices, Wireless Technology instrumentation
- Abstract
Wireless modules that provide telecommunications and power-harvesting capabilities enabled by radio-frequency (RF) electronics are vital components of skin-interfaced stretchable electronics
1-7 . However, recent studies on stretchable RF components have demonstrated that substantial changes in electrical properties, such as a shift in the antenna resonance frequency, occur even under relatively low elastic strains8-15 . Such changes lead directly to greatly reduced wireless signal strength or power-transfer efficiency in stretchable systems, particularly in physically dynamic environments such as the surface of the skin. Here we present strain-invariant stretchable RF electronics capable of completely maintaining the original RF properties under various elastic strains using a 'dielectro-elastic' material as the substrate. Dielectro-elastic materials have physically tunable dielectric properties that effectively avert frequency shifts arising in interfacing RF electronics. Compared with conventional stretchable substrate materials, our material has superior electrical, mechanical and thermal properties that are suitable for high-performance stretchable RF electronics. In this paper, we describe the materials, fabrication and design strategies that serve as the foundation for enabling the strain-invariant behaviour of key RF components based on experimental and computational studies. Finally, we present a set of skin-interfaced wireless healthcare monitors based on strain-invariant stretchable RF electronics with a wireless operational distance of up to 30 m under strain., (© 2024. The Author(s), under exclusive licence to Springer Nature Limited.)- Published
- 2024
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42. Central neurocytoma exhibits radial glial cell signatures with FGFR3 hypomethylation and overexpression.
- Author
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Lee Y, Chowdhury T, Kim S, Yu HJ, Kim KM, Kang H, Kim MS, Kim JW, Kim YH, Ji SY, Hwang K, Han JH, Hwang J, Yoo SK, Lee KS, Choe G, Won JK, Park SH, Lee YK, Shin JH, Park CK, Kim CY, and Kim JI
- Subjects
- Humans, Gene Expression Regulation, Neoplastic, Receptor, Fibroblast Growth Factor, Type 3 genetics, Receptor, Fibroblast Growth Factor, Type 3 metabolism, DNA Methylation, Neurocytoma genetics, Neurocytoma pathology, Neurocytoma metabolism, Ependymoglial Cells metabolism, Ependymoglial Cells pathology
- Abstract
We explored the genomic events underlying central neurocytoma (CN), a rare neoplasm of the central nervous system, via multiomics approaches, including whole-exome sequencing, bulk and single-nuclei RNA sequencing, and methylation sequencing. We identified FGFR3 hypomethylation leading to FGFR3 overexpression as a major event in the ontogeny of CN that affects crucial downstream events, such as aberrant PI3K-AKT activity and neuronal development pathways. Furthermore, we found similarities between CN and radial glial cells based on analyses of gene markers and CN tumor cells and postulate that CN tumorigenesis is due to dysregulation of radial glial cell differentiation into neurons. Our data demonstrate the potential role of FGFR3 as one of the leading drivers of tumorigenesis in CN., (© 2024. The Author(s).)
- Published
- 2024
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- View/download PDF
43. Publisher Correction: Re-evaluation of battery-grade lithium purity toward sustainable batteries.
- Author
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Choe G, Kim H, Kwon J, Jung W, Park KY, and Kim YT
- Published
- 2024
- Full Text
- View/download PDF
44. Comparing pronunciation challenges in South Korean preschoolers with unilateral single-sided deafness due to cochlear nerve deficiency to a norm-referenced standard.
- Author
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Choe G, Lim JW, Lee HJ, Kim SH, Carandang M, Kim BJ, and Choi BY
- Subjects
- Child, Preschool, Humans, Retrospective Studies, Language, Vocabulary, Language Development, Cochlear Nerve, Hearing Loss, Unilateral, Deafness surgery, Cochlear Implants, Cochlear Implantation, Speech Perception physiology
- Abstract
This study aimed to compare the development of pronunciation in South Korean preschoolers with unilateral cochlear nerve deficiency (CND) to that of age-matched preschoolers with normal hearing, a topic that has not been explored previously. In a retrospective analysis, 25 preschoolers with unilateral CND who had undergone a speech evaluation battery, including a pronunciation and vocabulary test, were enrolled. Utilizing the Urimal Test of Articulation and Phonation and customized language ability tests, pronunciation and vocabulary were assessed. The subjects' speech evaluation scores were converted into age-adjusted z-scores using normal controls' data. While vocabulary performance was within normal limits, their average pronunciation z-score was -2.90, significantly lower than both the zero reference point and their vocabulary z-scores. None of the subjects scored above average in pronunciation. Thirteen patients were recommended for articulation therapy, seven were considered as potential candidates for this therapy, and the remaining five were within normal limits. There was no observed correlation between the development of pronunciation and vocabulary. Notably, some subjects' pronunciation scores did not improve, even after serial follow-up during their preschool years. Despite typical vocabulary development, preschoolers with unilateral CND exhibit significant delays in pronunciation. These findings emphasize the necessity for vigilant monitoring of their language development., Competing Interests: The authors have declared that no competing interests exist., (Copyright: © 2024 Choe et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
- Published
- 2024
- Full Text
- View/download PDF
45. Re-evaluation of battery-grade lithium purity toward sustainable batteries.
- Author
-
Choe G, Kim H, Kwon J, Jung W, Park KY, and Kim YT
- Abstract
Recently, the cost of lithium-ion batteries has risen as the price of lithium raw materials has soared and fluctuated. Notably, the highest cost of lithium production comes from the impurity elimination process to satisfy the battery-grade purity of over 99.5%. Consequently, re-evaluating the impact of purity becomes imperative for affordable lithium-ion batteries. In this study, we unveil that a 1% Mg impurity in the lithium precursor proves beneficial for both the lithium production process and the electrochemical performance of resulting cathodes. This is attributed to the increased nucleation seeds and unexpected site-selective doping effects. Moreover, when extended to an industrial scale, low-grade lithium is found to reduce production costs and CO
2 emissions by up to 19.4% and 9.0%, respectively. This work offers valuable insights into the genuine sustainability of lithium-ion batteries., (© 2024. The Author(s).)- Published
- 2024
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- View/download PDF
46. Primary Intracranial Ewing Sarcoma With EWSR1-FLI1 Gene Translocation Mimicking a Meningioma and a Multidisciplinary Therapeutic Approach: A Case Report and Systematic Review of Literatures.
- Author
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Hyun C, Lee Y, Kang H, Park HJ, Suh KJ, Choi BS, Choe G, and Kim CY
- Abstract
Ewing sarcoma and peripheral primitive neuroectodermal tumor (ES/pPNET) is an undifferentiated malignant tumor that is most prevalent in children and young adults and often radiologically mimics a meningioma. A 38-year-old female patient visited our hospital with complaints of right-sided tinnitus, right hemiparesis, and imbalance. She underwent preoperative imaging and was subsequently diagnosed as having a meningioma on the petrous ridge. After partial resection, EWSR1-FLI1 gene fusion was confirmed, and she was diagnosed with ES/pPNET. The tumor was successfully treated using a multidisciplinary approach of adjuvant chemo- and radiotherapy. This case is noteworthy because it is an extremely rare case of an intracranial ES/pPNET, and it is worth sharing our clinical experience that the tumor was successfully treated through a multidisciplinary therapeutic approach even though complete resection was not achieved., Competing Interests: Chae-Yong Kim, a contributing editor of Brain Tumor Research and Treatment, was not involved in the editorial evaluation or decision to publish this article. All remaining authors have declared no conflicts of interest., (Copyright © 2023 The Korean Brain Tumor Society, The Korean Society for Neuro-Oncology, and The Korean Society for Pediatric Neuro-Oncology.)
- Published
- 2023
- Full Text
- View/download PDF
47. Hearing loss in neonates and infants.
- Author
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Choe G, Park SK, and Kim BJ
- Abstract
Hearing in neonates and infants is crucial for their development of language and communication skills. Unless hearing loss is appropriately managed early, it can cause a significant socioeconomic burden considering its detrimental impact on the child's development and its common nature. It is also the most common congenital sensory deficit, with an approximate incidence of 1.5 per 1,000 newborns. Its etiologies are heterogeneous: genetic causes are reportedly involved in up to 80% of cases, while congenital cytomegalovirus infection is the leading environmental factor contributing to congenital hearing loss. The introduction of newborn hearing screening using automated auditory brainstem response and/or automated otoacoustic emission in many developed countries has helped detect and manage hearing loss early. Current auditory rehabilitation options such as cochlear implantation implementing cutting-edge technologies can treat almost all degrees of hearing loss, emphasizing the importance of early hearing detection and intervention. Rapidly developing genetic diagnostic technologies and future cutting-edge treatment options, including gene therapy, will shed light on the future management of hearing loss in neonates and infants.
- Published
- 2023
- Full Text
- View/download PDF
48. A paintable and adhesive hydrogel cardiac patch with sustained release of ANGPTL4 for infarcted heart repair.
- Author
-
Lee M, Kim YS, Park J, Choe G, Lee S, Kang BG, Jun JH, Shin Y, Kim M, Ahn Y, and Lee JY
- Abstract
The infarcted heart undergoes irreversible pathological remodeling after reperfusion involving left ventricle dilation and excessive inflammatory reactions in the infarcted heart, frequently leading to fatal functional damage. Extensive attempts have been made to attenuate pathological remodeling in infarcted hearts using cardiac patches and anti-inflammatory drug delivery. In this study, we developed a paintable and adhesive hydrogel patch using dextran-aldehyde (dex-ald) and gelatin, incorporating the anti-inflammatory protein, ANGPTL4, into the hydrogel for sustained release directly to the infarcted heart to alleviate inflammation. We optimized the material composition, including polymer concentration and molecular weight, to achieve a paintable, adhesive hydrogel using 10% gelatin and 5% dex-ald, which displayed in-situ gel formation within 135 s, cardiac tissue-like modulus (40.5 kPa), suitable tissue adhesiveness (4.3 kPa), and excellent mechanical stability. ANGPTL4 was continuously released from the gelatin/dex-ald hydrogel without substantial burst release. The gelatin/dex-ald hydrogel could be conveniently painted onto the beating heart and degraded in vivo. Moreover, in vivo studies using animal models of acute myocardial infarction revealed that our hydrogel cardiac patch containing ANGPTL4 significantly improved heart tissue repair, evaluated by echocardiography and histological evaluation. The heart tissues treated with ANGPTL4-loaded hydrogel patches exhibited increased vascularization, reduced inflammatory macrophages, and structural maturation of cardiac cells. Our novel hydrogel system, which allows for facile paintability, appropriate tissue adhesiveness, and sustained release of anti-inflammatory drugs, will serve as an effective platform for the repair of various tissues, including heart, muscle, and cartilage., Competing Interests: The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Jae Young Lee reports financial support was provided by 10.13039/501100003725National Research Foundation of Korea., (© 2023 The Authors.)
- Published
- 2023
- Full Text
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49. Diffuse Leptomeningeal Glioneuronal Tumor with FGFR1 Mutation in a 29-Year-Old Male.
- Author
-
Kim M, Lee KR, Choe G, Hwang K, and Kim JH
- Abstract
This study reports on diffuse leptomeningeal glioneuronal tumor (DL-GNT) in a 29-year-old male. DL-GNT is a rare central nervous system (CNS) tumor mostly seen in children and only few cases have been reported in adult patients. Our patient presented with a chronic headache that lasted for five months. MR imaging showed mild hydrocephalus, multiple rim-enhancing nodular lesions in the suprasellar cistern, diffuse leptomeningeal enhancement in the lumbosacral area, and multiple small non-enhancing cyst-appearing lesions not suppressed on fluid attenuated inversion recovery (FLAIR) images in the bilateral basal ganglia, thalami, and cerebral hemispheres. Under the impression of germ cell tumor with leptomeningeal seeding, the patient underwent trans-sphenoidal tumor removal. DL-GNT was pathologically confirmed and FGFR1 mutation was detected through a next-generation sequencing test. In conclusion, a combination of leptomeningeal enhancement and multiple parenchymal non-enhancing cyst-appearing lesions not suppressed on FLAIR images may be helpful for differential diagnosis despite overlapping imaging features with many other CNS diseases that have leptomeningeal enhancement., Competing Interests: Conflicts of Interest: The authors have no potential conflicts of interest to disclose., (Copyrights © 2023 The Korean Society of Radiology.)
- Published
- 2023
- Full Text
- View/download PDF
50. Self-assembled peptide-substance P hydrogels alleviate inflammation and ameliorate the cartilage regeneration in knee osteoarthritis.
- Author
-
Kim SJ, Kim JE, Choe G, Song DH, Kim SJ, Kim TH, Yoo J, Kim SH, and Jung Y
- Abstract
Background: Self-assembled peptide (SAP)-substance P (SP) hydrogels can be retained in the joint cavity longer than SP alone, and they can alleviate inflammation and ameliorate cartilage regeneration in knee osteoarthritis (OA). We conducted a preclinical study using diverse animal models of OA and an in vitro study using human synoviocytes and patient-derived synovial fluids to demonstrate the effect of SAP-SP complex on the inflammation and cartilage regeneration., Methods: Surgical induction OA model was prepared with New Zealand white female rabbits and chemical induction, and naturally occurring OA models were prepared using Dunkin Hartely female guinea pigs. The SAP-SP complex or control (SAP, SP, or saline) was injected into the joint cavities in each model. We performed micro-computed tomography (Micro-CT) analysis, histological evaluation, immunofluorescent analysis, and terminal deoxynucleotidyl transferase deoxyuridine triphosphate nick-end labeling (TUNEL) assay and analyzed the recruitment of intrinsic mesenchymal stem cells (MSCs), macrophage activity, and inflammatory cytokine in each OA model. Human synoviocytes were cultured in synovial fluid extracted from human OA knee joints injected with SAP-SP complexes or other controls. Proliferative capacity and inflammatory cytokine levels were analyzed., Results: Alleviation of inflammation, inhibition of apoptosis, and enhancement of intrinsic MSCs have been established in the SAP-SP group in diverse animal models. Furthermore, the inflammatory effects on human samples were examined in synoviocytes and synovial fluid from patients with OA. In this study, we observed that SAP-SP showed anti-inflammatory action in OA conditions and increased cartilage regeneration by recruiting intrinsic MSCs, inhibiting progression of OA., Conclusions: These therapeutic effects have been validated in diverse OA models, including rabbits, Dunkin Hartley guinea pigs, and human synoviocytes. Therefore, we propose that SAP-SP may be an effective injectable therapeutic agent for treating OA. In this manuscript, we report a preclinical study of novel self-assembled peptide (SAP)-substance P (SP) hydrogels with diverse animal models and human synoviocytes and it displays anti-inflammatory effects, apoptosis inhibition, intrinsic mesenchymal stem cells recruitments and cartilage regeneration., (© 2023. The Author(s).)
- Published
- 2023
- Full Text
- View/download PDF
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