118 results on '"Fusco, Domenico"'
Search Results
2. Frailty modifies the effect of polypharmacy and multimorbidity on the risk of death among nursing home residents: Results from the SHELTER study
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Zazzara, Maria Beatrice, Villani, Emanuele Rocco, Palmer, Katie, Fialova, Daniela, Corsonello, Andrea, Soraci, Luca, Fusco, Domenico, Cipriani, Maria Camilla, Denkinger, Michael, Onder, Graziano, Liperoti, Rosa, Onder, Graziano (ORCID:0000-0003-3400-4491), Liperoti, Rosa (ORCID:0000-0003-3740-1687), Zazzara, Maria Beatrice, Villani, Emanuele Rocco, Palmer, Katie, Fialova, Daniela, Corsonello, Andrea, Soraci, Luca, Fusco, Domenico, Cipriani, Maria Camilla, Denkinger, Michael, Onder, Graziano, Liperoti, Rosa, Onder, Graziano (ORCID:0000-0003-3400-4491), and Liperoti, Rosa (ORCID:0000-0003-3740-1687)
- Abstract
BackgroundFrailty, disability, and polypharmacy are prevalent in nursing home (NH) residents, often co-occurring with multimorbidity. There may be a complex interplay among them in terms of outcomes such as mortality. Aims of the study were to (i) assess whether nursing home residents with polypharmacy (5-9 medications) or hyperpolypharmacy (>= 10 drugs), have an increased risk of death and (ii) whether any association is modified by the co-presence of frailty or disability. MethodsCohort study with longitudinal mortality data including 4,023 residents from 50 European and 7 Israeli NH facilities (mean age = 83.6 years, 73.2% female) in The Services and Health for Elderly in Long Term care (SHELTER) cohort study. Participants were evaluated with the interRAI-LongTerm Care assessment tool. Frailty was evaluated with the FRAIL-NH scale. Hazard ratio (HR) of death over 12 months was assessed with stratified Cox proportional hazards models adjusted for demographics, facilities, and cognitive status. Results1,042 (25.9%) participants were not on polypharmacy, 49.8% (n = 2,002) were on polypharmacy, and 24.3% (n = 979) on hyperpolypharmacy. Frailty and disability mostly increased risk of death in the study population (frailty: HR = 1.85, 95%CI 1.49-2.28; disability: HR = 2.10, 95%CI 1.86-2.47). Among non-frail participants, multimorbidity (HR = 1.34, 95%CI = 1.01-1.82) and hyperpolypharmacy (HR = 1.61, 95%CI = 1.09-2.40) were associated with higher risk of death. Among frail participants, no other factors were associated with mortality. Polypharmacy and multimorbidity were not associated with mortality after stratification for disability. ConclusionsFrailty and disability are the strongest predictors of death in NH residents. Multimorbidity and hyperpolypharmacy increase mortality only in people without frailty. These findings may be relevant to identify patients who could benefit from tailored deprescription.
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- 2023
3. An unusual presentation of sex cord-stromal tumors
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Gallo, Antonella, Lipari, Alice, Fusco, Domenico, Brandi, Vincenzo, Montalto, Massimo, Gallo A., Lipari A., Fusco D., Brandi V., Montalto M. (ORCID:0000-0001-8819-3684), Gallo, Antonella, Lipari, Alice, Fusco, Domenico, Brandi, Vincenzo, Montalto, Massimo, Gallo A., Lipari A., Fusco D., Brandi V., and Montalto M. (ORCID:0000-0001-8819-3684)
- Abstract
N/A
- Published
- 2023
4. Frailty modifies the effect of polypharmacy and multimorbidity on the risk of death among nursing home residents: Results from the SHELTER study
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Zazzara, Maria Beatrice, primary, Villani, Emanuele Rocco, additional, Palmer, Katie, additional, Fialova, Daniela, additional, Corsonello, Andrea, additional, Soraci, Luca, additional, Fusco, Domenico, additional, Cipriani, Maria Camilla, additional, Denkinger, Michael, additional, Onder, Graziano, additional, and Liperoti, Rosa, additional
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- 2023
- Full Text
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5. Rapidly Progressive Malignant Pelvic Perivascular Epithelioid Cell Neoplasm (PEComa) Associated with Eggerthella lenta Bloodstream Infection
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Cacciatore, Stefano, primary, Recupero, Carla, additional, Massaro, Claudia, additional, Elmi, Daniele, additional, Fusco, Domenico, additional, Badiali, Vanessa, additional, Brandi, Vincenzo, additional, Arciuolo, Damiano, additional, Marazzi, Fabio, additional, and Landi, Francesco, additional
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- 2022
- Full Text
- View/download PDF
6. Subacute onset dystonia in a woman affected by Parkinson's disease following SARS-COV-2 infection
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Lo Monaco, Maria Rita, Bentivoglio, Anna Rita, Fusco, Domenico, Calabresi, Paolo, Piano, Carla, Lo Monaco, Maria Rita (ORCID:0000-0002-1457-7981), Bentivoglio, Anna Rita (ORCID:0000-0002-9663-095X), Calabresi, Paolo (ORCID:0000-0003-0326-5509), Lo Monaco, Maria Rita, Bentivoglio, Anna Rita, Fusco, Domenico, Calabresi, Paolo, Piano, Carla, Lo Monaco, Maria Rita (ORCID:0000-0002-1457-7981), Bentivoglio, Anna Rita (ORCID:0000-0002-9663-095X), and Calabresi, Paolo (ORCID:0000-0003-0326-5509)
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N/A
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- 2021
7. Should face masks be worn to contain the spread of COVID-19 in the postlockdown phase?
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Landi, Francesco, Marzetti, Emanuele, Sanguinetti, Maurizio, Ciciarello, Francesca, Tritto, Marcello, Benvenuto, Francesca, Bramato, Giulia, Brandi, Vincenzo, Carfì, Angelo, D'Angelo, Emanuela, Fusco, Domenico, Lo Monaco, Maria Rita, Martone, Anna Maria, Pagano, Francesco Cosimo, Rocchi, Sara, Rota, Elisabetta, Russo, Andrea, Salerno, Andrea Maria, Cattani Franchi, Paola, Marchetti, Simona, Bernabei, Roberto, Landi, Francesco (ORCID:0000-0002-3472-1389), Marzetti, Emanuele (ORCID:0000-0001-9567-6983), Sanguinetti, Maurizio (ORCID:0000-0002-9780-7059), Lo Monaco, Maria Rita (ORCID:0000-0002-1457-7981), Pagano, Francesco, Salerno, Andrea, Cattani, Paola (ORCID:0000-0003-4678-4763), Bernabei On Behalf Of The Gemelli Against Covid-Geriatric Team, Roberto (ORCID:0000-0002-9197-004X), Landi, Francesco, Marzetti, Emanuele, Sanguinetti, Maurizio, Ciciarello, Francesca, Tritto, Marcello, Benvenuto, Francesca, Bramato, Giulia, Brandi, Vincenzo, Carfì, Angelo, D'Angelo, Emanuela, Fusco, Domenico, Lo Monaco, Maria Rita, Martone, Anna Maria, Pagano, Francesco Cosimo, Rocchi, Sara, Rota, Elisabetta, Russo, Andrea, Salerno, Andrea Maria, Cattani Franchi, Paola, Marchetti, Simona, Bernabei, Roberto, Landi, Francesco (ORCID:0000-0002-3472-1389), Marzetti, Emanuele (ORCID:0000-0001-9567-6983), Sanguinetti, Maurizio (ORCID:0000-0002-9780-7059), Lo Monaco, Maria Rita (ORCID:0000-0002-1457-7981), Pagano, Francesco, Salerno, Andrea, Cattani, Paola (ORCID:0000-0003-4678-4763), and Bernabei On Behalf Of The Gemelli Against Covid-Geriatric Team, Roberto (ORCID:0000-0002-9197-004X)
- Abstract
Background: In East Asia, face masks are commonly worn to reduce viral spread. In Euope and North America, however, their use has been stigmatised for a long time, although this view has radically changed during the ongoing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. Notwithstanding this, it is still unclear whether face masks worn by COVID-19 carriers may indeed prevent viral transmission and environmental contamination. The objective of this study was to evaluate the effectiveness of surgical face masks in filtering SARS-CoV-2.Methods: Four male patients with COVID-19 were recruited for the study. Two patients wore a surgical mask for 5 h, while two others did not. The spread of the virus in the environment was evaluated through the approved Allplex 2019-nCoV assay.Results: In the room with the two patients without surgical masks, the swab performed on the headboard and sides of the beds was positive for SARS-CoV-2 contamination. In the other room, where two patients were wearing surgical masks, all of the swabs obtained after 5 h tested negative.Conclusions: The results of the current study add to the growing body of literature supporting the use of face masks as a measure to contain the spread of SARS-CoV-2 by retaining potentially contagious droplets that can infect other people and/or contaminate surfaces. Based on the current evidence, face masks should therefore be considered a useful and low-cost device in addition to social distancing and hand hygiene during the postlockdown phase.
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- 2021
8. What about the caregiver? A journey into Parkinson's disease following the burden tracks
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Lo Monaco, Maria Rita, Di Stasio, Enrico, Ricciardi, Diego, Solito, Marcella, Petracca, Martina, Fusco, Domenico, Onder, Graziano, Landi, Giovanni, Zuccala', Giuseppe, Liperoti, Rosa, Cipriani, Maria Camilla, Brisi, Caterina, Bernabei, Roberto, Silveri, Maria Caterina, Bentivoglio, Anna Rita, Lo Monaco, Maria Rita (ORCID:0000-0002-1457-7981), Di Stasio, Enrico (ORCID:0000-0003-1047-4261), Onder, Graziano (ORCID:0000-0003-3400-4491), Zuccalà, Giuseppe (ORCID:0000-0002-2567-2220), Liperoti, Rosa (ORCID:0000-0003-3740-1687), Bernabei, Roberto (ORCID:0000-0002-9197-004X), Silveri, Maria Caterina (ORCID:0000-0001-5012-0682), Bentivoglio, Anna Rita (ORCID:0000-0002-9663-095X), Lo Monaco, Maria Rita, Di Stasio, Enrico, Ricciardi, Diego, Solito, Marcella, Petracca, Martina, Fusco, Domenico, Onder, Graziano, Landi, Giovanni, Zuccala', Giuseppe, Liperoti, Rosa, Cipriani, Maria Camilla, Brisi, Caterina, Bernabei, Roberto, Silveri, Maria Caterina, Bentivoglio, Anna Rita, Lo Monaco, Maria Rita (ORCID:0000-0002-1457-7981), Di Stasio, Enrico (ORCID:0000-0003-1047-4261), Onder, Graziano (ORCID:0000-0003-3400-4491), Zuccalà, Giuseppe (ORCID:0000-0002-2567-2220), Liperoti, Rosa (ORCID:0000-0003-3740-1687), Bernabei, Roberto (ORCID:0000-0002-9197-004X), Silveri, Maria Caterina (ORCID:0000-0001-5012-0682), and Bentivoglio, Anna Rita (ORCID:0000-0002-9663-095X)
- Abstract
Objectives To investigate caregivers and patients characteristics related to different dimensions of burden in Parkinson's disease (PD). Methods 55 pairs of PD patients and caregivers were recruited. The burden was evaluated with the Caregiver Burden Inventory (CBI). Multivariate analysis was applied to evaluate the impact of caregivers' and patients' characteristics on the varying aspects of burden. Results ADL score was the dominant predictor for the total score and all dimensions of CBI, except for the social burden, which is strongly predicted by the motor severity of PD. As one can easily imagine, the Total CBI decreases as the ADL score increases. Discussion An increased appreciation for characteristics of caregiver burden is a fundamental aspect of the patient's global evaluation. Clinicians may need to directly probe for these factors in the caregiver as they may not be elicited routinely.
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- 2021
9. Different impact of definitions of sarcopenia in defining frailty status in a population of older women with early breast cancer
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Bellieni, Agnese, Fusco, Domenico, Sanchez, A. M., Franceschini, Gianluca, Di Capua, B., Allocca, E., Di Stasio, Enrico, Marazzi, Fabio, Tagliaferri, Luca, Masetti, Riccardo, Bernabei, Roberto, Colloca, Giuseppe Ferdinando, Bellieni A., Fusco D., Franceschini G. (ORCID:0000-0002-2950-3395), Di Stasio E. (ORCID:0000-0003-1047-4261), Marazzi F., Tagliaferri L. (ORCID:0000-0003-2308-0982), Masetti R. (ORCID:0000-0002-7520-9111), Bernabei R. (ORCID:0000-0002-9197-004X), Colloca G. F., Bellieni, Agnese, Fusco, Domenico, Sanchez, A. M., Franceschini, Gianluca, Di Capua, B., Allocca, E., Di Stasio, Enrico, Marazzi, Fabio, Tagliaferri, Luca, Masetti, Riccardo, Bernabei, Roberto, Colloca, Giuseppe Ferdinando, Bellieni A., Fusco D., Franceschini G. (ORCID:0000-0002-2950-3395), Di Stasio E. (ORCID:0000-0003-1047-4261), Marazzi F., Tagliaferri L. (ORCID:0000-0003-2308-0982), Masetti R. (ORCID:0000-0002-7520-9111), Bernabei R. (ORCID:0000-0002-9197-004X), and Colloca G. F.
- Abstract
Sarcopenia is a geriatric syndrome characterized by losses of quantity and quality of skeletal muscle, which is associated with negative outcomes in older adults and in cancer patients. Different definitions of sarcopenia have been used, with quantitative data more frequently used in oncology, while functional measures have been advocated in the geriatric literature. Little is known about the correlation between frailty status as assessed by comprehensive geriatric assessment (CGA) and sarcopenia in cancer patients. We retrospectively analyzed data from 96 older women with early breast cancer who underwent CGAs and Dual X-ray Absorptiometry (DXA) scans for muscle mass assessment before cancer treatment at a single cancer center from 2016 to 2019 to explore the correlation between frailty status as assessed by CGA and sarcopenia using different definitions. Based on the results of the CGA, 35 patients (36.5%) were defined as frail. Using DXA Appendicular Skeletal Mass (ASM) or the Skeletal Muscle Index (SMI=ASM/heightˆ2), 41 patients were found to be sarcopenic (42.7%), with no significant difference in prevalence between frail and nonfrail subjects. Using the European Working Group on Sarcopenia in Older People (EWGSOP2) definition of sarcopenia (where both muscle function and mass are required), 58 patients were classified as “probably” sarcopenic; among these, 25 were sarcopenic and 17 “severely” sarcopenic. Only 13 patients satisfied both the requirements for being defined as sarcopenic and frail. Grade 3-4 treatment-related toxicities (according to Common Terminology Criteria for Adverse Events) were more common in sarcopenic and frail sarcopenic patients. Our data support the use of a definition of sarcopenia that includes both quantitative and functional data in order to identify frail patients who need tailored treatment.
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- 2021
10. Gender may be related to the side of the motor syndrome and cognition in idiopathic Parkinson's disease
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Bentivoglio, Anna Rita, Lo Monaco, Maria Rita, Liperoti, Rosa, Fusco, Domenico, Di Stasio, Enrico, Tondinelli, A., Marzullo, D., Maino, Alessandro, Cipriani, Maria Camilla, Silveri, Maria Caterina, Bentivoglio A. R. (ORCID:0000-0002-9663-095X), Lo Monaco M. R. (ORCID:0000-0002-1457-7981), Liperoti R. (ORCID:0000-0003-3740-1687), Fusco D., Di Stasio E. (ORCID:0000-0003-1047-4261), Maino A., Cipriani M. C., Silveri M. C. (ORCID:0000-0001-5012-0682), Bentivoglio, Anna Rita, Lo Monaco, Maria Rita, Liperoti, Rosa, Fusco, Domenico, Di Stasio, Enrico, Tondinelli, A., Marzullo, D., Maino, Alessandro, Cipriani, Maria Camilla, Silveri, Maria Caterina, Bentivoglio A. R. (ORCID:0000-0002-9663-095X), Lo Monaco M. R. (ORCID:0000-0002-1457-7981), Liperoti R. (ORCID:0000-0003-3740-1687), Fusco D., Di Stasio E. (ORCID:0000-0003-1047-4261), Maino A., Cipriani M. C., and Silveri M. C. (ORCID:0000-0001-5012-0682)
- Abstract
Background: and Sex and cognitive profile may be related to the laterality of motor symptoms in idiopathic Parkinson's disease. Introduction: Parkinson's disease (PD) is well recognised as an inherently asymmetric disease with unilateral onset of motor symptoms. The laterality of motor symptoms may be linked to sex, clinical and demographic variables, and neuropsychological disorders. However, the available data are inconsistent. This study aimed to explore the potential association between the laterality of motor symptoms and clinical and demographic variables and deficits in specific cognitive domains. Material and methods: We retrospectively recruited 97 participants with idiopathic PD without dementia; 60 presented motor symptoms on the left side and 37 on the right side. Both groups were comparable in terms of age, age at disease onset, disease duration, and severity of the neurological deficits according to the Unified Parkinson's Disease Rating Scale and the Hoehn and Yahr scale. Results: Participants with left-side motor symptoms scored lower on the Schwab and England Activities of Daily Living scale. Our sample included more men than women (67% vs. 33%). Both sexes were not equally represented in the 2 groups: there were significantly more men than women in the group of patients with left-side motor symptoms (77% vs. 23%), whereas the percentages of men and women in the group of patients with right-side motor symptoms were similar (51% vs. 49%). Both groups performed similarly in all neuropsychological tasks, but women, independently of laterality, performed better than men in the naming task. Conclusion: We found a clear prevalence of men in the group of patients with left-side motor symptoms; this group also scored lower on the Schwab and England Scale. Female sex was predictive of better performance in the naming task. Sex should always be considered in disorders that cause asymmetric involvement of the brain, such as PD.
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- 2021
11. Perspectives and limits of cancer treatment in an oldest old population
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Di Capua, B., Bellieni, A., Fusco, Domenico, Gambacorta, Maria Antonietta, Tagliaferri, Luca, Villani, Emanuele Rocco, Bernabei, Roberto, Valentini, Vincenzo, Colloca, Giuseppe Ferdinando, Fusco D., Gambacorta M. A. (ORCID:0000-0001-5455-8737), Tagliaferri L. (ORCID:0000-0003-2308-0982), Villani E. R., Bernabei R. (ORCID:0000-0002-9197-004X), Valentini V. (ORCID:0000-0003-4637-6487), Colloca G. F., Di Capua, B., Bellieni, A., Fusco, Domenico, Gambacorta, Maria Antonietta, Tagliaferri, Luca, Villani, Emanuele Rocco, Bernabei, Roberto, Valentini, Vincenzo, Colloca, Giuseppe Ferdinando, Fusco D., Gambacorta M. A. (ORCID:0000-0001-5455-8737), Tagliaferri L. (ORCID:0000-0003-2308-0982), Villani E. R., Bernabei R. (ORCID:0000-0002-9197-004X), Valentini V. (ORCID:0000-0003-4637-6487), and Colloca G. F.
- Abstract
Background: Population of oldest old will grow dramatically in the next future and cancer, physiologically related to aging, will be very prevalent among them. Lack of evidence is a huge problem to manage cancer in oldest old and will be more and more in the next years. Aims: Our purpose was to investigate the characteristics of a population of oldest old patients with cancer treated in the Radiation Oncology Unit of Fondazione Policlinico A. Gemelli IRCCS. Methods: We conducted a retrospective study. The primary outcome was to evaluate which characteristics of the population could influence the choice of oncological treatment (with radical or non-radical intent). Results: We identified a total of 348 patients: 140 were on follow-up; 177 were under treatment; 31 were considered not eligible for treatments. Patients under treatment had a high comorbidity index (mean Charlson Comorbidity Index 5.4), and a high prevalence of polypharmacy (mean number of drugs 5.6). More than half (53.1%) was treated with radical intent. Patients treated with radical intent were 1 year younger (87.1 years old vs 88.1 years old), more performant (ECOG 0.7 vs 1.3), and had less prevalence of metastatic neoplasia (6.4% vs 34.9%); comorbidities and drugs did not show differences in the two groups. Conclusion: Oldest old, usually not considered in international guidelines, are treated for oncological disease, often with radical intent. The treatment seems not to be tailored considering comorbidities but on performance status.
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- 2021
12. Different Impact of Definitions of Sarcopenia in Defining Frailty Status in a Population of Older Women with Early Breast Cancer. J Pers Med. 11(4):243. PMID: 33810556
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Biellini, A, Fusco, Domenico, Sanchez, Am, Franceschini, Gianluca, Di Capua, B, Allocca, E, Di Stasio, Enrico, Marazzi, Fabio, Tagliaferri, Luca, Masetti, Riccardo, Bernabei, Roberto, Colloca, Giuseppe Ferdinando, Fusco D, Franceschini G (ORCID:0000-0002-2950-3395), Di Stasio E (ORCID:0000-0003-1047-4261), Marazzi F, Tagliaferri L (ORCID:0000-0003-2308-0982), Masetti R (ORCID:0000-0002-7520-9111), Bernabei R (ORCID:0000-0002-9197-004X), Colloca GF., Biellini, A, Fusco, Domenico, Sanchez, Am, Franceschini, Gianluca, Di Capua, B, Allocca, E, Di Stasio, Enrico, Marazzi, Fabio, Tagliaferri, Luca, Masetti, Riccardo, Bernabei, Roberto, Colloca, Giuseppe Ferdinando, Fusco D, Franceschini G (ORCID:0000-0002-2950-3395), Di Stasio E (ORCID:0000-0003-1047-4261), Marazzi F, Tagliaferri L (ORCID:0000-0003-2308-0982), Masetti R (ORCID:0000-0002-7520-9111), Bernabei R (ORCID:0000-0002-9197-004X), and Colloca GF.
- Abstract
Sarcopenia is a geriatric syndrome characterized by losses of quantity and quality of skeletal muscle, which is associated with negative outcomes in older adults and in cancer patients. Different definitions of sarcopenia have been used, with quantitative data more frequently used in oncology, while functional measures have been advocated in the geriatric literature. Little is known about the correlation between frailty status as assessed by comprehensive geriatric assessment (CGA) and sarcopenia in cancer patients. We retrospectively analyzed data from 96 older women with early breast cancer who underwent CGAs and Dual X-ray Absorptiometry (DXA) scans for muscle mass assessment before cancer treatment at a single cancer center from 2016 to 2019 to explore the correlation between frailty status as assessed by CGA and sarcopenia using different definitions. Based on the results of the CGA, 35 patients (36.5%) were defined as frail. Using DXA Appendicular Skeletal Mass (ASM) or the Skeletal Muscle Index (SMI=ASM/heightˆ2), 41 patients were found to be sarcopenic (42.7%), with no significant difference in prevalence between frail and nonfrail subjects. Using the European Working Group on Sarcopenia in Older People (EWGSOP2) definition of sarcopenia (where both muscle function and mass are required), 58 patients were classified as “probably” sarcopenic; among these, 25 were sarcopenic and 17 “severely” sarcopenic. Only 13 patients satisfied both the requirements for being defined as sarcopenic and frail. Grade 3-4 treatment-related toxicities (according to Common Terminology Criteria for Adverse Events) were more common in sarcopenic and frail sarcopenic patients. Our data support the use of a definition of sarcopenia that includes both quantitative and functional data in order to identify frail patients who need tailored treatment.
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- 2021
13. Gender may be related to the side of the motorsyndrome and cognition in idiopathic Parkinson’sdisease
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Bentivoglio, Anna Rita, Lo Monaco, Maria Rita, Liperoti, Rosa, Fusco, Domenico, Di Stasio, Enrico, Tondinelli, A, Maino, A, Marzullo, D, Cipriani, Maria Camilla, Silveri, Maria Caterina, Bentivoglio AR (ORCID:0000-0002-9663-095X), Lo Monaco MR (ORCID:0000-0002-1457-7981), Liperoti R (ORCID:0000-0003-3740-1687), Fusco D, Di Stasio E (ORCID:0000-0003-1047-4261), Cipriani MC, Silveri MC (ORCID:0000-0001-5012-0682), Bentivoglio, Anna Rita, Lo Monaco, Maria Rita, Liperoti, Rosa, Fusco, Domenico, Di Stasio, Enrico, Tondinelli, A, Maino, A, Marzullo, D, Cipriani, Maria Camilla, Silveri, Maria Caterina, Bentivoglio AR (ORCID:0000-0002-9663-095X), Lo Monaco MR (ORCID:0000-0002-1457-7981), Liperoti R (ORCID:0000-0003-3740-1687), Fusco D, Di Stasio E (ORCID:0000-0003-1047-4261), Cipriani MC, and Silveri MC (ORCID:0000-0001-5012-0682)
- Abstract
Parkinson's disease s a well recognised
- Published
- 2021
14. Different Impact of Definitions of Sarcopenia in Defining Frailty Status in a Population of Older Women with Early Breast Cancer
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Bellieni, Andrea, primary, Fusco, Domenico, additional, Sanchez, Alejandro Martin, additional, Franceschini, Gianluca, additional, Di Capua, Beatrice, additional, Allocca, Elena, additional, Di Stasio, Enrico, additional, Marazzi, Fabio, additional, Tagliaferri, Luca, additional, Masetti, Riccardo, additional, Bernabei, Roberto, additional, and Colloca, Giuseppe Ferdinando, additional
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- 2021
- Full Text
- View/download PDF
15. Subacute onset dystonia in a woman affected by Parkinson’s disease following SARS-COV-2 infection
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Lo Monaco, Maria Rita, primary, Bentivoglio, Anna Rita, additional, Fusco, Domenico, additional, Calabresi, Paolo, additional, and Piano, Carla, additional
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- 2021
- Full Text
- View/download PDF
16. Assessment of neurological manifestations in hospitalized patients with COVID-19
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Luigetti, M., Iorio, R., Bentivoglio, A. R., Tricoli, L., Riso, V., Marotta, J., Piano, C., Primiano, G., Zileri Del Verme, L., Lo Monaco, M. R., Calabresi, P., Abbate, Valeria, Acampora, Nicola, Addolorato, Giovanni, Agostini, Fabiana, Ainora, Maria Elena, Akacha, Karim, Amato, Elena, Andreani, Francesca, Andriollo, Gloria, Annetta, Maria Giuseppina, Annicchiarico, Brigida Eleonora, Antonelli, Mariangela, Antonucci, Gabriele, Anzellotti, Gian Marco, Armuzzi, Alessandro, Baldi, Fabiana, Barattucci, Ilaria, Barillaro, Christian, Barone, Fabiana, Bellantone, Rocco Domenico Alfonso, Bellieni, Andrea, Bello, Giuseppe, Benicchi, Andrea, Benvenuto, Francesca, Berardini, Ludovica, Berloco, Filippo, Bernabei, Roberto, Bianchi, Antonio, Biasucci, Daniele Guerino, Biasucci, Luigi Marzio, Bibbò, Stefano, Bini, Alessandra, Bisanti, Alessandra, Biscetti, Federico, Bocci, Maria Grazia, Bonadia, Nicola, Bongiovanni, Filippo, Borghetti, Alberto, Bosco, Giulia, Bosello, Silvia, Bove, Vincenzo, Bramato, Giulia, Brandi, Vincenzo, Bruni, Teresa, Bruno, Carmine, Bruno, Dario, Bungaro, Maria Chiara, Buonomo, Alessandro, Burzo, Livia, Calabrese, Angelo, Calvello, Maria Rosaria, Cambieri, Andrea, Cambise, Chiara, Cammà, Giulia, Candelli, Marcello, Canistro, Gennaro, Cantanale, Antonello, Capalbo, Gennaro, Capaldi, Lorenzo, Capone, Emanuele, Capristo, Esmeralda, Carbone, Luigi, Cardone, Silvia, Carelli, Simone, Carfì, Angelo, Carnicelli, Annamaria, Caruso, Cristiano, Casciaro, Francesco Antonio, Catalano, Lucio, Cauda, Roberto, Cecchini, Andrea Leonardo, Cerrito, Lucia, Cesarano, Melania, Chiarito, Annalisa, Cianci, Rossella, Cicchinelli, Sara, Ciccullo, Arturo, Cicetti, Marta, Ciciarello, Francesca, Cingolani, Antonella, Cipriani, Maria Camilla, Consalvo, Maria Ludovica, Coppola, Gaetano, Corbo, Giuseppe Maria, Corsello, Andrea, Costante, Federico, Costanzi, Matteo, Covino, Marcello, Crupi, Davide, Cutuli, Salvatore Lucio, DAddio, Stefano, DAlessandro, Alessia, DAlfonso, Maria Elena, DAngelo, Emanuela, DAversa, Francesca, Damiano, Fernando, De Berardinis, Gian Maria, De Cunzo, Tommaso, De Gaetano, Donati Katleen, De Luca, Giulio, De Matteis, Giuseppe, De Pascale, Gennaro, De Santis, Paolo, De Siena, Martina, De Vito, Francesco, Del Gatto, Valeria, Del Giacomo, Paola, Del Zompo, Fabio, DellAnna, Antonio Maria, Della, Polla Davide, Di Gialleonardo, Luca, Di Giambenedetto, Simona, Di Luca, Roberta, Di Maurizio, Luca, Di Muro, Mariangela, Dusina, Alex, Eleuteri, Davide, Esperide, Alessandra, Fachechi, Daniele, Faliero, Domenico, Falsiroli, Cinzia, Fantoni, Massimo, Fedele, Annalaura, Feliciani, Daniela, Ferrante, Cristina, Ferrone, Giuliano, Festa, Rossano, Fiore, Maria Chiara, Flex, Andrea, Forte, Evelina, Franceschi, Francesco, Francesconi, Alessandra, Franza, Laura, Funaro, Barbara, Fuorlo, Mariella, Fusco, Domenico, Gabrielli, Maurizio, Gaetani, Eleonora, Galletta, Claudia, Gallo, Antonella, Gambassi, Giovanni, Garcovich, Matteo, Gasbarrini, Antonio, Gasparrini, Irene, Gelli, Silvia, Giampietro, Antonella, Gigante, Laura, Giuliano, Gabriele, Giuliano, Giorgia, Giupponi, Bianca, Gremese, Elisa, Grieco, Domenico Luca, Guerrera, Manuel, Guglielmi, Valeria, Guidone, Caterina, Gullì, Antonio, Iaconelli, Amerigo, Iafrati, Aurora, Ianiro, Gianluca, Iaquinta, Angela, Impagnatiello, Michele, Inchingolo, Riccardo, Intini, Enrica, Iorio, Raffaele, Izzi, Immacolata Maria, Jovanovic, Tamara, Kadhim, Cristina, La Macchia, Rosa, La Milia, Daniele Ignazio, Landi, Francesco, Landi, Giovanni, Landi, Rosario, Landolfi, Raffaele, Leo, Massimo, Leone, Paolo Maria, Levantesi, Laura, Liguori, Antonio, Liperoti, Rosa, Lizzio, Marco Maria, Lo Monaco Maria, Rita, Locantore, Pietro, Lombardi, Francesco, Lombardi, Gianmarco, Lopetuso, Loris, Loria, Valentina, Losito, Angela Raffaella, Lucia, Mothanje Barbara Patricia, Macagno, Francesco, Macerola, Noemi, Maggi, Giampaolo, Maiuro, Giuseppe, Mancarella, Francesco, Mangiola, Francesca, Manno, Alberto, Marchesini, Debora, Maresca, Gian Marco, Marrone, Giuseppe, Martis, Ilaria, Martone, Anna Maria, Marzetti, Emanuele, Mattana, Chiara, Matteo, Maria Valeria, Maviglia, Riccardo, Mazzarella, Ada, Memoli, Carmen, Miele, Luca, Migneco, Alessio, Mignini, Irene, Milani, Alessandro, Milardi, Domenico, Montalto, Massimo, Montemurro, Giuliano, Monti, Flavia, Montini, Luca, Morena, Tony Christian, Morra, Vincenzina, Morretta, Chiara, Moschese, Davide, Murace, Celeste Ambra, Murdolo, Martina, Murri, Rita, Napoli, Marco, Nardella, Elisabetta, Natalello, Gerlando, Natalini, Daniele, Navarra, Simone Maria, Nesci, Antonio, Nicoletti, Alberto, Nicoletti, Rocco, Nicoletti, Tommaso Filippo, Nicolò, Rebecca, Nicolotti, Nicola, Nista, Enrico Celestino, Nuzzo, Eugenia, Oggiano, Marco, Ojetti, Veronica, Pagano, Francesco Cosimo, Paiano, Gianfranco, Pais, Cristina, Pallavicini, Federico, Palombo, Andrea, Paolillo, Federico, Papa, Alfredo, Papanice, Domenico, Papparella, Luigi Giovanni, Paratore, Mattia, Parrinello, Giuseppe, Pasciuto, Giuliana, Pasculli, Pierpaolo, Pecorini, Giovanni, Perniola, Simone, Pero, Erika, Petricca, Luca, Petrucci, Martina, Picarelli, Chiara, Piccioni, Andrea, Piccolo, Annalisa, Piervincenzi, Edoardo, Pignataro, Giulia, Pignataro, Raffaele, Pintaudi, Gabriele, Pisapia, Luca, Pizzoferrato, Marco, Pizzolante, Fabrizio, Pola, Roberto, Policola, Caterina, Pompili, Maurizio, Pontecorvi, Flavia, Pontecorvi, Valerio, Ponziani, Francesca, Popolla, Valentina, Porceddu, Enrica, Porfidia, Angelo, Porro, Lucia Maria, Potenza, Annalisa, Pozzana, Francesca, Privitera, Giuseppe, Pugliese, Daniela, Pulcini, Gabriele, Racco, Simona, Raffaelli, Francesca, Ramunno, Vittoria, Rapaccini, Gian Ludovico, Richeldi, Luca, Rinninella, Emanuele, Rocchi, Sara, Romanò, Bruno, Romano, Stefano, Rosa, Federico, Rossi, Laura, Rossi, Raimondo, Rossini, Enrica, Rota, Elisabetta, Rovedi, Fabiana, Rubino, Carlotta, Rumi, Gabriele, Russo, Andrea, Sabia, Luca, Salerno, Andrea, Salini, Sara, Salvatore, Lucia, Samori, Dehara, Sandroni, Claudio, Sanguinetti, Maurizio, Santarelli, Luca, Santini, Paolo, Santolamazza, Danilo, Santoliquido, Angelo, Santopaolo, Francesco, Santoro, Michele Cosimo, Sardeo, Francesco, Sarnari, Caterina, Saviano, Angela, Saviano, Luisa, Scaldaferri, Franco, Scarascia, Roberta, Schepis, Tommaso, Schiavello, Francesca, Scoppettuolo, Giancarlo, Sedda, Davide, Sessa, Flaminio, Sestito, Luisa, Settanni, Carlo, Siciliano, Matteo, Siciliano, Valentina, Sicuranza, Rossella, Simeoni, Benedetta, Simonetti, Jacopo, Smargiassi, Andrea, Soave, Paolo Maurizio, Sonnino, Chiara, Staiti, Domenico, Stella, Claudia, Stella, Leonardo, Stival, Eleonora, Taddei, Eleonora, Talerico, Rossella, Tamburello, Elio, Tamburrini, Enrica, Tanzarella, Eloisa Sofia, Tarascio, Elena, Tarli, Claudia, Tersali, Alessandra, Tilli, Pietro, Timpano, Jacopo, Torelli, Enrico, Torrini, Flavia, Tosato, Matteo, Tosoni, Alberto, Tricoli, Luca, Tritto, Marcello, Tumbarello, Mario, Tummolo, Anita Maria, Vallecoccia, Maria Sole, Valletta, Federico, Varone, Francesco, Vassalli, Francesco, Ventura, Giulio, Verardi, Lucrezia, Vetrone, Lorenzo, Vetrugno, Giuseppe, Visconti, Elena, Visconti, Felicia, Viviani, Andrea, Zaccaria, Raffaella, Zaccone, Carmelina, Zelano, Lorenzo, Zileri Dal Verme, Lorenzo, and Zuccalà, Giuseppe
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Male ,Hospitalized patients ,muscle ,Settore M-PSI/02 - PSICOBIOLOGIA E PSICOLOGIA FISIOLOGICA ,neurological disorders ,0302 clinical medicine ,Hyposmia ,030212 general & internal medicine ,Respiratory system ,education.field_of_study ,Brain Diseases ,Headache ,virus diseases ,Neuromuscular Diseases ,Middle Aged ,Hospitalization ,medicine.anatomical_structure ,Neurology ,Female ,medicine.symptom ,Adult ,medicine.medical_specialty ,SARS‐CoV2 ,Coronavirus disease 2019 (COVID-19) ,Patients ,Short Communication ,Anosmia ,precision medicine ,Population ,Encephalopathy ,Short Communications ,Clinical Neurology ,Settore MED/26 ,03 medical and health sciences ,COVID‐19 ,Internal medicine ,Throat ,Influenza, Human ,medicine ,Humans ,education ,Aged ,Retrospective Studies ,business.industry ,SARS-CoV-2 ,COVID-19 ,Hypoxia (medical) ,medicine.disease ,respiratory tract diseases ,body regions ,Neurology (clinical) ,Nervous System Diseases ,business ,030217 neurology & neurosurgery - Abstract
Background and purpose The objective of this study was to assess the neurological manifestations in a series of consecutive severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-positive patients, comparing their frequency with a population hospitalized in the same period for flu/respiratory symptoms, finally not related to SARS-CoV-2. Methods Patients with flu/respiratory symptoms admitted to Fondazione Policlinico Gemelli hospital from 14 March 2020 to 20 April 2020 were retrospectively enrolled. The frequency of neurological manifestations of patients with SARS-CoV-2 infection was compared with a control group. Results In all, 213 patients were found to be positive for SARS-CoV-2, after reverse transcriptase polymerase chain reaction on nasal or throat swabs, whilst 218 patients were found to be negative and were used as a control group. Regarding central nervous system manifestations, in SARS-CoV-2-positive patients a higher frequency of headache, hyposmia and encephalopathy always related to systemic conditions (fever or hypoxia) was observed. Furthermore, muscular involvement was more frequent in SARS-CoV-2 infection. Conclusions Patients with COVID-19 commonly have neurological manifestations but only hyposmia and muscle involvement seem more frequent compared with other flu diseases.
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- 2020
17. Safinamide as an adjunct therapy in older patients with Parkinson's disease : a retrospective study
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Lo Monaco, Maria Rita, Petracca, Martina, Vetrano, Davide Liborio, Di Stasio, Enrico, Fusco, Domenico, Ricciardi, Diego, Laudisio, Alice, Zuccalà, Giuseppe, Onder, Graziano, Bentivoglio, Anna Rita, Lo Monaco, Maria Rita, Petracca, Martina, Vetrano, Davide Liborio, Di Stasio, Enrico, Fusco, Domenico, Ricciardi, Diego, Laudisio, Alice, Zuccalà, Giuseppe, Onder, Graziano, and Bentivoglio, Anna Rita
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Background Safinamide, as a levodopa adjunct, is effective in reducing motor fluctuations in Parkinson's disease (PD) patients; however, scarce evidence is available regarding its use in older PD patients. Aim To evaluate the safety and tolerability of safinamide as an adjunct therapy in patients aged >= 60 years with advanced PD. Methods A retrospective study including 203 PD patients admitted to a geriatric day hospital, who were evaluated following an extensive clinical protocol. Safinamide use was categorized as never used, ongoing, and withdrawn. Potential correlations of Safinamide withdrawal were investigated in stepwise backward logistic regression models. Results A total of 44 out of 203 participants were current or former users of Safinamide. Overall, 14 (32%) patients discontinued due to treatment-emergent adverse events (TEAEs). Withdrawal was not associated with older age. Conclusions Safinamide as an adjunct therapy in patients aged >= 60 years with advanced PD was found to be safe and well-tolerated in older patients. There were no specific demographic or clinical characteristics associated with suspension.
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- 2020
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18. Untangling the relationship between fat distribution, nutritional status and Parkinson's disease severity
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Pisciotta, Maria S., Fusco, Domenico, Grande, Giulia, Brandi, Vincenzo, Lo Monaco, Maria R., Laudisio, Alice, Onder, Graziano, Bentivoglio, Anna R., Ricciardi, Diego, Bernabei, Roberto, Zuccala, Giuseppe, Vetrano, Davide L., Pisciotta, Maria S., Fusco, Domenico, Grande, Giulia, Brandi, Vincenzo, Lo Monaco, Maria R., Laudisio, Alice, Onder, Graziano, Bentivoglio, Anna R., Ricciardi, Diego, Bernabei, Roberto, Zuccala, Giuseppe, and Vetrano, Davide L.
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Background Parkinson's disease (PD) is responsible for significant changes in body composition. Aims We aimed to test the association between PD severity and fat distribution patterns, and to investigate the potential modifier effect of nutritional status in this association. Methods We enrolled 195 PD subjects consecutively admitted to a university geriatric day hospital. All participants underwent comprehensive clinical evaluation, including assessment of total and regional body composition (dual-energy X-ray absorptiometry, DXA), body mass index, nutritional status (Mini-Nutritional Assessment, MNA), motor disease severity (UPDRS III), comorbidities, and pharmacotherapy. Results The fully adjusted linear regression model showed a negative association between UPDRS III and total body fat in kg and percentage (respectively, B - 0.79; 95% CI - 1.54 to - 0.05 and B - 0.55; 95% CI - 1.04 to - 0.05), percentage android fat (B - 1.07; 95% CI - 1.75 to - 0.39), trunk-leg fat ratio (B - 0.02; 95% CI - 0.04 to - 0.01), trunk-limb fat ratio (B - 0.01; 95% CI - 0.06 to - 0.01) and android-gynoid fat ratio (B - 0.01; 95% CI - 0.03 to - 0.01). After stratification by MNA score, all the parameters of android-like fat distribution resulted negatively associated (p < 0.001 for all) with UPDRS III, but only among subjects with a MNA < 23.5 (risk of malnutrition or malnutrition). Conclusion We found a negative association between severity of motor impairment and total fat mass in PD, more specific with respect to an android pattern of fat distribution. This association seems to be driven by nutritional status, and is significant only among patients at risk of malnutrition or with overt malnutrition.
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- 2020
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19. The “development of metabolic and functional markers of dementia in older people” (ODINO) study: Rationale, design and methods
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Picca, A., Ronconi, D., Coelho-Junior, H. J., Calvani, Riccardo, Marini, F., Biancolillo, A., Gervasoni, Jacopo, Primiano, A., Pais, C., Meloni, E., Fusco, Domenico, Lo Monaco, Maria Rita, Bernabei, Roberto, Camilla Cipriani, M., Marzetti, Emanuele, Liperoti, Rosa, Calvani R. (ORCID:0000-0001-5472-2365), Gervasoni J., Fusco D., Lo Monaco M. R. (ORCID:0000-0002-1457-7981), Bernabei R. (ORCID:0000-0002-9197-004X), Marzetti E. (ORCID:0000-0001-9567-6983), Liperoti R. (ORCID:0000-0003-3740-1687), Picca, A., Ronconi, D., Coelho-Junior, H. J., Calvani, Riccardo, Marini, F., Biancolillo, A., Gervasoni, Jacopo, Primiano, A., Pais, C., Meloni, E., Fusco, Domenico, Lo Monaco, Maria Rita, Bernabei, Roberto, Camilla Cipriani, M., Marzetti, Emanuele, Liperoti, Rosa, Calvani R. (ORCID:0000-0001-5472-2365), Gervasoni J., Fusco D., Lo Monaco M. R. (ORCID:0000-0002-1457-7981), Bernabei R. (ORCID:0000-0002-9197-004X), Marzetti E. (ORCID:0000-0001-9567-6983), and Liperoti R. (ORCID:0000-0003-3740-1687)
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Mild cognitive impairment (MCI), also termed mild neurocognitive disorder, includes a heterogeneous group of conditions characterized by declines in one or more cognitive domains greater than that expected during "normal" aging but not severe enough to impair functional abilities. MCI has been associated with an increased risk of developing dementia and even considered an early stage of it. Therefore, noninvasively accessible biomarkers of MCI are highly sought after for early identification of the condition. Systemic inflammation, metabolic perturbations, and declining physical performance have been described in people with MCI. However, whether biological and functional parameters differ across MCI neuropsychological subtypes is presently debated. Likewise, the predictive value of existing biomarkers toward MCI conversion into dementia is unclear. The "develOpment of metabolic and functional markers of Dementia IN Older people" (ODINO) study was conceived as a multi-dimensional investigation in which multi-marker discovery will be coupled with innovative statistical approaches to characterize patterns of systemic inflammation, metabolic perturbations, and physical performance in older adults with MCI. The ultimate aim of ODINO is to identify potential biomarkers specific for MCI subtypes and predictive of MCI conversion into Alzheimer's disease or other forms of dementia over a three-year follow-up. Here, we describe the rationale, design, and methods of ODINO.
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- 2020
20. Prevalence of Obsessive-Compulsive Symptoms in Elderly Parkinson Disease Patients: A Case-Control Study
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Lo Monaco, Maria Rita, Di Stasio, Enrico, Zuccala', Giuseppe, Petracca, Martina, Genovese, Maria Daniela, Fusco, Domenico, Silveri, Maria Caterina, Liperoti, Rosa, Ricciardi, Diego, Cipriani, Maria Camilla, Laudisio, A., Bentivoglio, Anna Rita, Lo Monaco M. R. (ORCID:0000-0002-1457-7981), Di Stasio E. (ORCID:0000-0003-1047-4261), Zuccala G. (ORCID:0000-0002-2567-2220), Petracca M., Genovese D., Fusco D., Silveri M. C. (ORCID:0000-0001-5012-0682), Liperoti R. (ORCID:0000-0003-3740-1687), Ricciardi D., Cipriani M. C., Bentivoglio A. R. (ORCID:0000-0002-9663-095X), Lo Monaco, Maria Rita, Di Stasio, Enrico, Zuccala', Giuseppe, Petracca, Martina, Genovese, Maria Daniela, Fusco, Domenico, Silveri, Maria Caterina, Liperoti, Rosa, Ricciardi, Diego, Cipriani, Maria Camilla, Laudisio, A., Bentivoglio, Anna Rita, Lo Monaco M. R. (ORCID:0000-0002-1457-7981), Di Stasio E. (ORCID:0000-0003-1047-4261), Zuccala G. (ORCID:0000-0002-2567-2220), Petracca M., Genovese D., Fusco D., Silveri M. C. (ORCID:0000-0001-5012-0682), Liperoti R. (ORCID:0000-0003-3740-1687), Ricciardi D., Cipriani M. C., and Bentivoglio A. R. (ORCID:0000-0002-9663-095X)
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Background: The clinical picture of obsessive-compulsive disorder encompasses a broad range of symptoms that are related to multiple psychological domains, including perception, cognition, emotion, and social relatedness. As obsessive-compulsive symptoms (OCS) frequently have an early onset, there are limited data about OCS in older populations (>= 65 years) and, in particular, in elderly subjects with Parkinson disease (PD). Objective: This study aimed to estimate the prevalence of OCS using a self-report measure (Obsessive-Compulsive Inventory-Revised) and to identify associated sociodemographic and clinical factors in a sample of elderly PD patients compared to a comparison group of similarly aged healthy volunteers. Results: The mean age was 74 +/- 6 years in the PD patients and 73 +/- 7 years in the comparison group. The mean disease duration was 9.6 +/- 5.8 years. Among the PD patients, 30.7% reported at least one OCS or a related disorder compared to 21.1% in the comparison group. Hoarding was significantly more common in PD patients than in the comparison group. Conclusions: Subclinical OCS were present at a high percentage in both PD patients and comparison group. The OCS phenotype in PD may present differently, as hoarding was more common in PD patients.
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- 2020
21. The Geriatrician: The Frontline Specialist in the Treatment of COVID-19 Patients
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Landi, Francesco, Barillaro, Christian, Bellieni, Andrea, Brandi, Vincenzo, Carfi', Angelo, Cipriani, Maria Camilla, D'Angelo, Emanuela, Falsiroli, Cinzia, Fusco, Domenico, Landi, Giovanni, Liperoti, Rosa, Lo Monaco, Maria Rita, Martone, Anna Maria, Marzetti, Emanuele, Pagano, Francesco Cosimo, Pais, Cristina, Russo, Andrea, Salini, Sara, Tosasto, Matteo, Tummolo, Anna Maria, Benvenuto, Francesca, Bramato, Giulia, Catalano, Lucia, Ciciarello, Francesca, Martis, Ilaria, Rocchi, Sara, Rota, Elisabetta, Salerno, Andrea Maria, Tritto, Marcello, Sgadari, Antonio, Zuccala', Giuseppe, Bernabei, Roberto, Landi, Francesco (ORCID:0000-0002-3472-1389), Carfi, Angelo, Liperoti, Rosa (ORCID:0000-0003-3740-1687), Lo Monaco, Maria Rita (ORCID:0000-0002-1457-7981), Marzetti, Emanuele (ORCID:0000-0001-9567-6983), Salerno, Andrea, Sgadari, Antonio (ORCID:0000-0002-8296-043X), Zuccàla, Giuseppe (ORCID:0000-0002-2567-2220), Bernabei, Roberto (ORCID:0000-0002-9197-004X), Landi, Francesco, Barillaro, Christian, Bellieni, Andrea, Brandi, Vincenzo, Carfi', Angelo, Cipriani, Maria Camilla, D'Angelo, Emanuela, Falsiroli, Cinzia, Fusco, Domenico, Landi, Giovanni, Liperoti, Rosa, Lo Monaco, Maria Rita, Martone, Anna Maria, Marzetti, Emanuele, Pagano, Francesco Cosimo, Pais, Cristina, Russo, Andrea, Salini, Sara, Tosasto, Matteo, Tummolo, Anna Maria, Benvenuto, Francesca, Bramato, Giulia, Catalano, Lucia, Ciciarello, Francesca, Martis, Ilaria, Rocchi, Sara, Rota, Elisabetta, Salerno, Andrea Maria, Tritto, Marcello, Sgadari, Antonio, Zuccala', Giuseppe, Bernabei, Roberto, Landi, Francesco (ORCID:0000-0002-3472-1389), Carfi, Angelo, Liperoti, Rosa (ORCID:0000-0003-3740-1687), Lo Monaco, Maria Rita (ORCID:0000-0002-1457-7981), Marzetti, Emanuele (ORCID:0000-0001-9567-6983), Salerno, Andrea, Sgadari, Antonio (ORCID:0000-0002-8296-043X), Zuccàla, Giuseppe (ORCID:0000-0002-2567-2220), and Bernabei, Roberto (ORCID:0000-0002-9197-004X)
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On February 20, 2020, a man living in the north of Italy was admitted to the emergency room with an atypical pneumonia that later proved to be COVID-19. This was the trigger of one of the most serious clusters of COVID-19 in the world, outside of China. Despite aggressive restraint and inhibition efforts, COVID-19 continues to increase, and the total number of infected patients in Italy is growing daily. After 6 weeks, the total number of patients reached 128,948 cases (April 5, 2020), with the higher case-fatality rate (15,887 deaths) dominated by old and very old patients.This sudden health emergency severely challenged the Italian Health System, in particular acute care hospitals and intensive care units. In 1 hospital, geriatric observation units were created, the experience of which can be extremely useful for European countries, the United States, and all countries that in the coming days will face a similar situation. (C) 2020 AMDA - The Society for Post-Acute and Long-Term Care Medicine.
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- 2020
22. The New Challenge of Geriatrics: Saving Frail Older People from the SARS-COV-2 Pandemic Infection
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Landi, Francesco, Barillaro, Christian, Bellieni, Agnese, Brandi, Vincenzo, Carfì, A, D'Angelo, M, Fusco, Domenico, Landi, G, Lo Monaco, Maria Rita, Martone, Anna Maria, Marzetti, Emanuele, Pagano, Francesco Cosimo, Pais, C, Russo, A, Salini, S, Tosato, Matteo, Tummolo, Aida Angela, Benvenuto, F, Bramato, Giulia, Catalano, Lucio, Ciciarello, Francesca, Martis, I, Rocchi, Sara, Rota, E, Salerno, Andrea Maria, Tritto, M, Sgadari, Antonio, Zuccala', Giuseppe, Bernabei, Roberto, Landi, F (ORCID:0000-0002-3472-1389), Barillaro, C, Bellieni, A, Brandi, V, Fusco, D, Lo Monaco, R (ORCID:0000-0002-1457-7981), Martone, A M, Marzetti, E (ORCID:0000-0001-9567-6983), Pagano, F, Tosato, M, Tummolo, A, Bramato, G, Catalano, L, Ciciarello, F, Rocchi, S, Salerno, A, Sgadari, A (ORCID:0000-0002-8296-043X), Zuccalà, G (ORCID:0000-0002-2567-2220), Bernabei, R (ORCID:0000-0002-9197-004X), Landi, Francesco, Barillaro, Christian, Bellieni, Agnese, Brandi, Vincenzo, Carfì, A, D'Angelo, M, Fusco, Domenico, Landi, G, Lo Monaco, Maria Rita, Martone, Anna Maria, Marzetti, Emanuele, Pagano, Francesco Cosimo, Pais, C, Russo, A, Salini, S, Tosato, Matteo, Tummolo, Aida Angela, Benvenuto, F, Bramato, Giulia, Catalano, Lucio, Ciciarello, Francesca, Martis, I, Rocchi, Sara, Rota, E, Salerno, Andrea Maria, Tritto, M, Sgadari, Antonio, Zuccala', Giuseppe, Bernabei, Roberto, Landi, F (ORCID:0000-0002-3472-1389), Barillaro, C, Bellieni, A, Brandi, V, Fusco, D, Lo Monaco, R (ORCID:0000-0002-1457-7981), Martone, A M, Marzetti, E (ORCID:0000-0001-9567-6983), Pagano, F, Tosato, M, Tummolo, A, Bramato, G, Catalano, L, Ciciarello, F, Rocchi, S, Salerno, A, Sgadari, A (ORCID:0000-0002-8296-043X), Zuccalà, G (ORCID:0000-0002-2567-2220), and Bernabei, R (ORCID:0000-0002-9197-004X)
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No abstract available
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- 2020
23. Tolerability of bevacizumab in elderly ovarian cancer patients (Turbo study): A case-control study of a real-life experience
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Amadio, G., Marchetti, Claudia, Villani, Emanuele Rocco, Fusco, Domenico, Stollagli, F., Bottoni, C., Distefano, Maria Grazia, Colloca, Giuseppe Ferdinando, Scambia, Giovanni, Fagotti, Anna, Marchetti C. (ORCID:0000-0001-7098-8956), Villani E. R., Fusco D., Distefano M., Colloca G., Scambia G. (ORCID:0000-0003-2758-1063), Fagotti A. (ORCID:0000-0001-5579-335X), Amadio, G., Marchetti, Claudia, Villani, Emanuele Rocco, Fusco, Domenico, Stollagli, F., Bottoni, C., Distefano, Maria Grazia, Colloca, Giuseppe Ferdinando, Scambia, Giovanni, Fagotti, Anna, Marchetti C. (ORCID:0000-0001-7098-8956), Villani E. R., Fusco D., Distefano M., Colloca G., Scambia G. (ORCID:0000-0003-2758-1063), and Fagotti A. (ORCID:0000-0001-5579-335X)
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Objective: Bevacizumab maintenance following platinum-based chemotherapy is an effective treatment for epithelial ovarian cancer (EOC), both in primary and recurrent disease. Our aim was to identify criteria to select elderly patients who can safely benefit from bevacizumab addition. Methods: This is a case-control study on patients with primary or recurrent EOC who received platinum-based chemotherapy plus bevacizumab, between January 2015 and December 2016. Patient characteristics, treatment details and adverse events were reviewed and analyzed in 2 settings: younger (<65 years, group 1) and elderly (≥65 years, group 2). A binary logistic model was applied to correlate clinical variables and severe (grade ≥3) toxicity risk. Results: Overall, 283 patients with EOC were included, with 72 (25.4%) older patients compared with 211 (74.6%) younger women. Bevacizumab had been administered to 234 patients (82.7%) as first-line treatment and in 49 (17.3%) with recurrent disease. At diagnosis, elderly patients presented with at least one comorbidity and were taking at least 1 medication in 84.7% and 80.6% of the cases respectively, compared with correspondingly 47.4% and 37.4% in group 1 (p<0.001). Nonetheless, the occurrence of serious (grade ≥3) adverse events did not increase among the older group. Creatinine serum levels >1.1 g/dL, estimated glomerular filtration rate (eGFR) ≤60 mL/min, ≥3 comorbidities were independently associated with a higher severe toxicity. Conclusions: Elderly patients with EOC can safely be treated with bevacizumab; factors other than age, as higher creatinine serum levels, eGFR and number of comorbidities should be considered to better estimate bevacizumab-related toxicity risk.
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- 2020
24. Cognitive Decline in Older Long-Term Survivors From Non-Hodgkin Lymphoma: A Multicenter Cross-Sectional Study
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La Carpia, Domenico, Liperoti, Rosa, Guglielmo, Mauro, Di Capua, Beatrice, Franca Devizzi, Liliana, Matteucci, Paola, Farina, Lucia, Fusco, Domenico, Colloca, Giuseppe Ferdinando, Di Pede, Patricia, Luciana Ferrara, Marianna, Hohaus, Stefan, Bernabei, Roberto, Ida Ripamonti, Carla, Rosa Liperoti (ORCID:0000-0003-3740-1687), Beatrice Di Capua, Domenico Fusco, Giuseppe Colloca, Stefan Hohaus (ORCID:0000-0002-5534-7197), Roberto Bernabei (ORCID:0000-0002-9197-004X), La Carpia, Domenico, Liperoti, Rosa, Guglielmo, Mauro, Di Capua, Beatrice, Franca Devizzi, Liliana, Matteucci, Paola, Farina, Lucia, Fusco, Domenico, Colloca, Giuseppe Ferdinando, Di Pede, Patricia, Luciana Ferrara, Marianna, Hohaus, Stefan, Bernabei, Roberto, Ida Ripamonti, Carla, Rosa Liperoti (ORCID:0000-0003-3740-1687), Beatrice Di Capua, Domenico Fusco, Giuseppe Colloca, Stefan Hohaus (ORCID:0000-0002-5534-7197), and Roberto Bernabei (ORCID:0000-0002-9197-004X)
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Objectives: To compare cognition in a group of older long-term survivors from Non-Hodgkin Lymphoma (NHL) and in a corresponding group of non-cancer controls of the same age. Functional status, polypharmacy and multimorbidity were also evaluated. Methods: A cross-sectional study was performed in a population of 63 outpatient long-term survivors from NHL, aged 65 or more and 61 non-cancer controls. Socio-demographic, clinical and functional data were collected. Cognitive function was assessed through neuropsychological tests. Results: NHL survivors showed a slightly worse functional status than controls, they were affected by more chronic conditions (3.4 vs 2.3; p = .003) and were taking a higher number of medications (3.4 vs 2.3; p = .03). The Mini Mental State Examination (MMSE) was not significantly different between the groups. NHL survivors performed worse than controls in executive functioning (Trail Making Test B-A 47.9 vs 32.1 p = .04, OR for Stroop test time over 75th percentile in survivors: 2.66; CI 95% 1.04-6.61; OR for Multiple Features Target Cancellation time over 75th percentile in survivors: 2.84; CI 95% 1.10-7.31). A small, statistically significant difference was also observed in verbal memory scores between the two groups. . Conclusions: The findings of this study suggest that, compared with non-cancer controls, older survivors from NHL may have a lower cognitive performance, especially in the executive functioning and attention domains, regardless of multimorbidity and polypharmacy. Further evidence from larger samples is needed to confirm such findings and better characterize cognitive decline in NHL survivors.
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- 2020
25. The importance of geriatric and surgical co-management of elderly in muscoloskeletal oncology: A literature review
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Vitiello, Raffaele, primary, Bellieni, Andrea, additional, Oliva, Maria Serena, additional, Di Capua, Beatrice, additional, Fusco, Domenico, additional, Careri, Silvia, additional, Colloca, Giuseppe Ferdinando, additional, Perisano, Carlo, additional, Maccauro, Giulio, additional, and Lillo, Marco, additional
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- 2020
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26. The “develOpment of metabolic and functional markers of Dementia IN Older people” (ODINO) Study: Rationale, Design and Methods
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Picca, Anna, primary, Ronconi, Daniela, additional, Coelho-Junior, Hélio J., additional, Calvani, Riccardo, additional, Marini, Federico, additional, Biancolillo, Alessandra, additional, Gervasoni, Jacopo, additional, Primiano, Aniello, additional, Pais, Cristina, additional, Meloni, Eleonora, additional, Fusco, Domenico, additional, Lo Monaco, Maria Rita, additional, Bernabei, Roberto, additional, Cipriani, Maria Camilla, additional, Marzetti, Emanuele, additional, and Liperoti, Rosa, additional
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- 2020
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27. ToleRability of BevacizUmab in elderly Ovarian cancer patients (TURBO study): a case-control study of a real-life experience
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Amadio, Giulia, primary, Marchetti, Claudia, additional, Villani, Emanuele Rocco, additional, Fusco, Domenico, additional, Stollagli, Francesca, additional, Bottoni, Carolina, additional, Distefano, Mariagrazia, additional, Colloca, Giuseppe, additional, Scambia, Giovanni, additional, and Fagotti, Anna, additional
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- 2020
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28. Association of Pisa Syndrome With Mortality in Patients With Parkinson's Disease
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Laudisio, Alice, Lo Monaco, Maria Rita, Vetrano, Davide L., Pisciotta, Maria Stella, Brandi, Vincenzo, Gemma, Antonella, Fusco, Domenico, Bernabei, Roberto, Incalzi, Raffaele Antonelli, Zuccala, Giuseppe, Laudisio, Alice, Lo Monaco, Maria Rita, Vetrano, Davide L., Pisciotta, Maria Stella, Brandi, Vincenzo, Gemma, Antonella, Fusco, Domenico, Bernabei, Roberto, Incalzi, Raffaele Antonelli, and Zuccala, Giuseppe
- Abstract
Objectives: In Parkinson's disease, Pisa syndrom (PS) has been associated with disease stage and severity, combined treatment with levodopa and dopamine agonists, gait disorders, and comorbidities. Some forms of PS are potentially reversible; nevertheless, little is known about the impact of this syndrome on survival. Design: Prospective study with a median follow-up of 2 years. Setting and participants: Patients with Parkinson's disease, age 65 years and older (N = 189), attending a geriatric day hospital. Measurements: According to established criteria, PS was diagnosed in the presence of at least 10 degrees lateral flexion of the trunk reducible by passive mobilization or supine positioning. Cox regression was adopted to assess the association of PS with all-cause mortality. Results: PS was diagnosed in 40 patients (21%); over the follow-up, 21 (11%) subjects died. In Cox regression, PS was associated with higher mortality [hazard ratio (HR) 4.10; 95% confidence interval (CI) = 1.36-12.38], after adjusting; other variables associated with mortality were age (HR = 1.19, 95% CI = 1.08-1.32), beta blockers (HR = 4.35, 95% CI = 1.23-15.39), and albumin levels (HR = 0.05, 95% CI = 0.01-0.33). The association of PS with mortality remained significant also after adjusting for variables associated with this syndrome (HR = 4.04, 95% CI = 1.33-12.25). Conclusions/Implications: PS represents a risk factor for earlier mortality in Parkinson's disease; further studies are needed to ascertain the underlying causes and whether treatment of this condition might improve survival. (C) 2019 AMDA - The Society for Post-Acute and Long-Term Care Medicine.
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- 2019
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29. Association of Pisa Syndrome With Mortality in Patients With Parkinson's Disease
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Laudisio, A, Lo Monaco, Maria Rita, Vetrano, Dl, Pisciotta, M, Brandi, V, Gemma, A, Fusco, Domenico, Bernabei, Roberto, Antonelli Incalzi, R, Zuccala', Giuseppe, Lo Monaco MR (ORCID:0000-0002-1457-7981), Fusco D, Bernabei R (ORCID:0000-0002-9197-004X), Zuccalà G (ORCID:0000-0002-2567-2220), Laudisio, A, Lo Monaco, Maria Rita, Vetrano, Dl, Pisciotta, M, Brandi, V, Gemma, A, Fusco, Domenico, Bernabei, Roberto, Antonelli Incalzi, R, Zuccala', Giuseppe, Lo Monaco MR (ORCID:0000-0002-1457-7981), Fusco D, Bernabei R (ORCID:0000-0002-9197-004X), and Zuccalà G (ORCID:0000-0002-2567-2220)
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OBJECTIVES: In Parkinson's disease, Pisa syndrom (PS) has been associated with disease stage and severity, combined treatment with levodopa and dopamine agonists, gait disorders, and comorbidities. Some forms of PS are potentially reversible; nevertheless, little is known about the impact of this syndrome on survival. DESIGN: Prospective study with a median follow-up of 2 years. SETTING AND PARTICIPANTS: Patients with Parkinson's disease, age 65 years and older (N = 189), attending a geriatric day hospital. MEASUREMENTS: According to established criteria, PS was diagnosed in the presence of at least 10° lateral flexion of the trunk reducible by passive mobilization or supine positioning. Cox regression was adopted to assess the association of PS with all-cause mortality. RESULTS: PS was diagnosed in 40 patients (21%); over the follow-up, 21 (11%) subjects died. In Cox regression, PS was associated with higher mortality [hazard ratio (HR) 4.10; 95% confidence interval (CI) = 1.36-12.38], after adjusting; other variables associated with mortality were age (HR = 1.19, 95% CI = 1.08-1.32), beta blockers (HR = 4.35, 95% CI = 1.23-15.39), and albumin levels (HR = 0.05, 95% CI = 0.01-0.33). The association of PS with mortality remained significant also after adjusting for variables associated with this syndrome (HR = 4.04, 95% CI = 1.33-12.25). CONCLUSIONS/IMPLICATIONS: PS represents a risk factor for earlier mortality in Parkinson's disease; further studies are needed to ascertain the underlying causes and whether treatment of this condition might improve survival.
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- 2019
30. Untangling the relationship between fat distribution, nutritional status and Parkinson's disease severity
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Pisciotta, Maria S, Fusco, Domenico, Grande, Giulia, Brandi, Vincenzo, Lo Monaco, Maria Rita, Laudisio, Alice, Onder, Graziano, Bentivoglio, Anna Rita, Ricciardi, Diego, Bernabei, Roberto, Zuccala', Giuseppe, Vetrano, Davide L, Lo Monaco, Maria R (ORCID:0000-0002-1457-7981), Onder, Graziano (ORCID:0000-0003-3400-4491), Bentivoglio, Anna R (ORCID:0000-0002-9663-095X), Bernabei, Roberto (ORCID:0000-0002-9197-004X), Zuccalà, Giuseppe (ORCID:0000-0002-2567-2220), Pisciotta, Maria S, Fusco, Domenico, Grande, Giulia, Brandi, Vincenzo, Lo Monaco, Maria Rita, Laudisio, Alice, Onder, Graziano, Bentivoglio, Anna Rita, Ricciardi, Diego, Bernabei, Roberto, Zuccala', Giuseppe, Vetrano, Davide L, Lo Monaco, Maria R (ORCID:0000-0002-1457-7981), Onder, Graziano (ORCID:0000-0003-3400-4491), Bentivoglio, Anna R (ORCID:0000-0002-9663-095X), Bernabei, Roberto (ORCID:0000-0002-9197-004X), and Zuccalà, Giuseppe (ORCID:0000-0002-2567-2220)
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BACKGROUND: Parkinson's disease (PD) is responsible for significant changes in body composition. AIMS: We aimed to test the association between PD severity and fat distribution patterns, and to investigate the potential modifier effect of nutritional status in this association. METHODS: We enrolled 195 PD subjects consecutively admitted to a university geriatric day hospital. All participants underwent comprehensive clinical evaluation, including assessment of total and regional body composition (dual-energy X-ray absorptiometry, DXA), body mass index, nutritional status (Mini-Nutritional Assessment, MNA), motor disease severity (UPDRS III), comorbidities, and pharmacotherapy. RESULTS: The fully adjusted linear regression model showed a negative association between UPDRS III and total body fat in kg and percentage (respectively, B - 0.79; 95% CI - 1.54 to - 0.05 and B - 0.55; 95% CI - 1.04 to - 0.05), percentage android fat (B - 1.07; 95% CI - 1.75 to - 0.39), trunk-leg fat ratio (B - 0.02; 95% CI - 0.04 to - 0.01), trunk-limb fat ratio (B - 0.01; 95% CI - 0.06 to - 0.01) and android-gynoid fat ratio (B - 0.01; 95% CI - 0.03 to - 0.01). After stratification by MNA score, all the parameters of android-like fat distribution resulted negatively associated (p < 0.001 for all) with UPDRS III, but only among subjects with a MNA < 23.5 (risk of malnutrition or malnutrition). CONCLUSION: We found a negative association between severity of motor impairment and total fat mass in PD, more specific with respect to an android pattern of fat distribution. This association seems to be driven by nutritional status, and is significant only among patients at risk of malnutrition or with overt malnutrition.
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- 2019
31. A reduction method to quasilinear hyperbolic systems of multicomponent field PDEs with application to wave interaction
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Currò, Carmela and Fusco, Domenico
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- 2002
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32. Sarcopenia in Parkinson Disease : Comparison of Different Criteria and Association With Disease Severity
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Vetrano, Davide L., Pisciotta, Maria S., Laudisio, Alice, Lo Monaco, Maria R., Onder, Graziano, Brandi, Vincenzo, Fusco, Domenico, Di Capua, Beatrice, Ricciardi, Diego, Bernabei, Roberto, Zuccala, Giuseppe, Vetrano, Davide L., Pisciotta, Maria S., Laudisio, Alice, Lo Monaco, Maria R., Onder, Graziano, Brandi, Vincenzo, Fusco, Domenico, Di Capua, Beatrice, Ricciardi, Diego, Bernabei, Roberto, and Zuccala, Giuseppe
- Abstract
Objectives: In Parkinson disease (PD), sarcopenia may represent the common downstream pathway that from motor and nonmotor symptoms leads to the progressive loss of resilience, frailty, and disability. Here we (1) assessed the prevalence of sarcopenia in older adults with PD using 3 different criteria, testing their agreement, and (2) evaluated the association between PD severity and sarcopenia. Design: Cross-sectional, observation study. Setting: Geriatric day hospital. Participants: Older adults with idiopathic PD. Measurements: Body composition was evaluated through dual energy x-ray absorptiometry. Handgrip strength and walking speed were measured. Sarcopenia was operationalized according to the Foundation for the National Institutes of Health, the European Working Group on Sarcopenia in Older Persons, and the International Working Group. Cohen k statistics was used to test the agreement among criteria. Results: Among the 210 participants (mean age 73 years; 38% women), the prevalence of sarcopenia was 28.5%-40.7% in men and 17.5%-32.5% in women. The prevalence of severe sarcopenia was 16.8%-20.0% in men and 11.3%-18.8% in women. The agreement among criteria was poor. The highest agreement was obtained between the European Working Group on Sarcopenia in Older Persons (severe sarcopenia) and International Working Group criteria (k = 0.52 in men; k = 0.65 in women; P < .01 for both). Finally, severe sarcopenia was associated with PD severity (odds ratio 2.30; 95% confidence interval 1.15-4.58). Conclusions: Sarcopenia is common in PD, with severe sarcopenia being diagnosed in 1 in every 5 patients with PD. We found a significant disagreement among the 3 criteria evaluated, in detecting sarcopenia more than in ruling it out. Finally, sarcopenia is associated with PD severity. Considering its massive prevalence, further studies should address the prognosis of sarcopenia in PD.
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- 2018
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33. Balancing the risks and benefits of antipsychotic medications for symptom management in older patients with cancer
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Liperoti, Rosa, Fusco, Domenico, Cipriani, Maria Camilla, Lo Monaco, Maria Rita, Onder, Graziano, Liperoti, Rosa (ORCID:0000-0003-3740-1687), Cipriani, Maria C., Lo Monaco, Maria R. (ORCID:0000-0002-1457-7981), Onder, Graziano (ORCID:0000-0003-3400-4491), Liperoti, Rosa, Fusco, Domenico, Cipriani, Maria Camilla, Lo Monaco, Maria Rita, Onder, Graziano, Liperoti, Rosa (ORCID:0000-0003-3740-1687), Cipriani, Maria C., Lo Monaco, Maria R. (ORCID:0000-0002-1457-7981), and Onder, Graziano (ORCID:0000-0003-3400-4491)
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NA
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- 2018
34. Laterality in Parkinson's disease may predict motor and visual imagery abilities
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Lo Monaco, Maria Rita, Laudisio, Alice, Fusco, Domenico, Vetrano, Davide Liborio, Ricciardi, Diego, Delle Donne, Valentina, Proietti, Francesca, Zuccala', Giuseppe, Silveri, Maria Caterina, Lo Monaco MR (ORCID:0000-0002-1457-7981), Laudisio A, Fusco D, Vetrano DL, Ricciardi D, Delle Donne V, Zuccalà G (ORCID:0000-0002-2567-2220), Silveri MC (ORCID:0000-0001-5012-0682), Lo Monaco, Maria Rita, Laudisio, Alice, Fusco, Domenico, Vetrano, Davide Liborio, Ricciardi, Diego, Delle Donne, Valentina, Proietti, Francesca, Zuccala', Giuseppe, Silveri, Maria Caterina, Lo Monaco MR (ORCID:0000-0002-1457-7981), Laudisio A, Fusco D, Vetrano DL, Ricciardi D, Delle Donne V, Zuccalà G (ORCID:0000-0002-2567-2220), and Silveri MC (ORCID:0000-0001-5012-0682)
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Experimental evidence suggests that motor imagery (MI) engages the same neural substrates supporting actual motor activities and is likely impaired when such substrates are damaged, as in Parkinson's disease (PD). MI intuitively relies on visual imagery (VI), because mental simulations of physical movements depend on the visual retrieval of these movements. Although VI is generally considered a right hemispheric function, the hemispheric dominance of MI is still in dispute. Disparities in sidedness of motor disturbances are a distinctive feature of PD, and recent findings indicate that such disparities may similarly characterize cognition. Specifically, the deficits observed may depend upon which hemisphere is principally involved. Essentially, MI and VI are cognitive tasks subject to differential impairment and reflecting the prevalence of hemispheric impairment in PD. Motor imagery (assessed by the Vividness of Motor Imagery Questionnaire [VMIQ]) and VI (assessed by the Vividness of Visual Imagery Questionnaire [VVIQ] and Test of Visual Imagery Control [TVIC]) were examined in patients with asymmetric PD and in healthy elderly control subjects (HC group). VMIQ scores were similar in PD laterality subsets and the HC group, but VVIQ scores were significantly lower in both PD groups compared with the HC group. TVIC scores were significantly lower in the presence of left motor (right hemispheric) impairment and were predictive of left motor (right hemispheric) impairment. We suspect that MI is strongly reliant on VI and that language may mediate these two functions, to the extent that both are evoked through verbal stimuli. Working memory, both visual and verbal, is also involved in MI and VI tasks. Without due attention to laterality of symptoms, any training incorporating MI and VI may not deliver expected outcomes in the setting of asymmetric PD symptomatology.
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- 2018
35. An update in breast cancer management for elderly patients
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Fusco, Domenico, primary, Allocca, Elena, additional, Villani, Emanuele Rocco, additional, Franza, Laura, additional, Laudisio, Alice, additional, and Colloca, Giuseppe, additional
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- 2018
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36. Impact of disease duration and cardiovascular dysautonomia on hypertension in Parkinson's disease
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Vetrano, Davide L., Pisciotta, Maria S., Brandi, Vincenzo, Lo Monaco, Maria R., Laudisio, Alice, Onder, Graziano, Fusco, Domenico, L'Angiocola, Paolo D., Bentivoglio, Anna R., Bernabei, Roberto, Zuccalà, Giuseppe, Vetrano, Davide L., Pisciotta, Maria S., Brandi, Vincenzo, Lo Monaco, Maria R., Laudisio, Alice, Onder, Graziano, Fusco, Domenico, L'Angiocola, Paolo D., Bentivoglio, Anna R., Bernabei, Roberto, and Zuccalà, Giuseppe
- Abstract
The authors evaluated the association of Parkinson's disease (PD) duration with hypertension, assessed by office measurements and 24-hour (ambulatory) monitoring, in 167 patients. Hypertension was evaluated through both office and ambulatory blood pressure (BP) measurements. Among participants (mean age 73.4 +/- 7.6years; 35% women), the prevalence of hypertension was 60% and 69% according to office and ambulatory BP measurements, respectively (Cohen's k=0.61; P<.001). PD duration was inversely associated with hypertension as diagnosed by office measurements (odds ratio [OR], 0.92; 95% confidence interval [CI], 0.86-0.98) but not by ambulatory monitoring (OR, 0.94; 95% CI, 0.81-1.01). Ambulatory BP patterns showed higher nocturnal BP among patients with long-lasting disease. In conclusion, ambulatory BP monitoring improves the detection of hypertension by 15% in PD, compared with office evaluation. The likelihood of having hypertension does not decrease during the PD course; rather, BP pattern shifts towards nocturnal hypertension.
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- 2017
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37. Bone mineral density in adults with Down syndrome
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Carfì, A., Liperoti, Rosa, Fusco, Domenico, Giovannini, Silvia, Brandi, V., Vetrano, D. L., Meloni, E., Mascia, Daniele, Villani, Emanuele Rocco, Manes Gravina, Ester, Bernabei, Roberto, Onder, Graziano, Liperoti, R. (ORCID:0000-0003-3740-1687), Fusco, D., Giovannini, S. (ORCID:0000-0001-9125-752X), Mascia, D. (ORCID:0000-0002-9255-3520), Manes Gravina, E., Bernabei, R. (ORCID:0000-0002-9197-004X), Onder, G. (ORCID:0000-0003-3400-4491), Carfì, A., Liperoti, Rosa, Fusco, Domenico, Giovannini, Silvia, Brandi, V., Vetrano, D. L., Meloni, E., Mascia, Daniele, Villani, Emanuele Rocco, Manes Gravina, Ester, Bernabei, Roberto, Onder, Graziano, Liperoti, R. (ORCID:0000-0003-3740-1687), Fusco, D., Giovannini, S. (ORCID:0000-0001-9125-752X), Mascia, D. (ORCID:0000-0002-9255-3520), Manes Gravina, E., Bernabei, R. (ORCID:0000-0002-9197-004X), and Onder, G. (ORCID:0000-0003-3400-4491)
- Abstract
Summary: This study analyzed data of bone mineral density (BMD) from a large cohort of adults with Down syndrome (DS). BMD was found to decrease with age more rapidly in these subjects than in the general population, exposing adults with DS to an increased risk of osteoporosis and bone fracture. Introduction: Down syndrome (DS) in adulthood presents with a high prevalence of osteoporosis. However, in DS, bone mineral density (BMD) can be underestimated due to short stature. Furthermore, the rate of age-related decline in BMD and its association with gender in DS has been rarely evaluated or compared with the general population. The present study is aimed at assessing the variation of BMD with age and gender in a sample of adults with DS and to compare these data with those of the general population, after adjusting for anthropometric differences. Methods: Adults with DS, aged 18 or older, were assessed dual-energy-X-ray-absorptiometry (DXA) at the femoral neck and at the lumbar spine. They were compared with the general population enrolled in the National Health and Nutrition Examination Survey (NHANES) 2009–2010 dataset. Bone mineral apparent density (BMAD) was calculated for each individual. Results: DXA was evaluated in 234 subjects with DS (mean age 36.93 ± 11.83 years, ranging from 20 to 69 years; 50.4% females). In the lumbar spine both mean BMD (DS 0.880 ± 0.141 vs. NHANES 1.062 ± 0.167, p < 0.001) and BMAD (DS 0.138 ± 0.020 vs. NHANES 0.152 ± 0.020, p < 0.001) were significantly lower in the DS sample than in the NAHNES cohort. The same trend was observed at the femoral neck in both BMD (DS 0.658 ± 0.128 vs. NHANES 0.835 ± 0.137, p < 0.001) and BMAD (DS 0.151 ± 0.030 vs. NHANES 0.159 ± 0.028, p<0.001). Age was associated with lower femoral neck BMAD in both samples; importantly, this association was significantly stronger in the DS sample. In the lumbar spine region, no significant association between BMAD and age could be observed in both samples. Conclusio
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- 2017
38. Ovarian cancer management in the oldest old: Improving outcomes and tailoring treatments
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Tortorella, Lucia, Vizzielli, Giuseppe, Fusco, Domenico, Cho, William C., Bernabei, Roberto, Scambia, Giovanni, Colloca, Giuseppe Ferdinando, Bernabei, Roberto (ORCID:0000-0002-9197-004X), Scambia, Giovanni (ORCID:0000-0003-2758-1063), Colloca, Giuseppe, Tortorella, Lucia, Vizzielli, Giuseppe, Fusco, Domenico, Cho, William C., Bernabei, Roberto, Scambia, Giovanni, Colloca, Giuseppe Ferdinando, Bernabei, Roberto (ORCID:0000-0002-9197-004X), Scambia, Giovanni (ORCID:0000-0003-2758-1063), and Colloca, Giuseppe
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Ovarian cancer is the most common cause of death from gynecological cancers in developed countries. It is a common disease of older women at or above 63 years upon diagnosis. Thanks to advance in new treatments, mortality from ovarian cancer has declined in developed countries in the last decade. This decline in mortality rate is unevenly distributed across the age-spectrum. While mortality in younger women has decreased 21.7%, for elderly women it has declined only 2.2%. Even if ovarian cancer is clearly a disease of the elderly, older women are underrepresented in clinical trials, and scant evidence exists for the treatment of women older than 80 years. Moreover, older women are frequently undertreated, receive less chemotherapy and less combination of surgery and chemotherapy, despite the fact that this is considered the optimal treatment modality. This may be mainly due to the lack of evidence and physician's confidence in the management of elderly women with ovarian cancer. In this review, we focus on the management of older women with ovarian cancer, considering geriatric features tied to this population.
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- 2017
39. Age-Related Variations of Muscle Mass, Strength, and Physical Performance in Community-Dwellers: Results From the Milan EXPO Survey
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Landi, Francesco, Calvani, Riccardo, Tosato, Matteo, Martone, Anna Maria, Fusco, Domenico, Sisto, Alex Nichola, Ortolani, Elena, Savera, Giulia, Salini, Sara, Marzetti, Emanuele, Landi, Francesco (ORCID:0000-0002-3472-1389), Calvani, Riccardo (ORCID:0000-0001-5472-2365), Sisto, Alex Nicholas, Marzetti, Emanuele (ORCID:0000-0001-9567-6983), Landi, Francesco, Calvani, Riccardo, Tosato, Matteo, Martone, Anna Maria, Fusco, Domenico, Sisto, Alex Nichola, Ortolani, Elena, Savera, Giulia, Salini, Sara, Marzetti, Emanuele, Landi, Francesco (ORCID:0000-0002-3472-1389), Calvani, Riccardo (ORCID:0000-0001-5472-2365), Sisto, Alex Nicholas, and Marzetti, Emanuele (ORCID:0000-0001-9567-6983)
- Abstract
Objectives Declining muscle mass and function are hallmarks of the aging process. The preservation of muscle trophism may protect against various negative health outcomes. Age- and sex-specific curves of muscle mass, strength, and function, using data from a large sample of community-dwelling people, are necessary. Material and methods Two surveys (Longevity Check-up and Very Important Protein [VIP]), conducted during EXPO 2015 in Milan, consisted of a population assessment aimed at evaluating the prevalence of specific health metrics in subjects outside of a research setting (n = 3206), with a special focus on muscle mass, strength, and function. Muscle mass was estimated by using mid-arm muscle circumference (MAMC) and calf circumference of the dominant side. Muscle strength and function were assessed through handgrip strength testing and repeated chair stand test, respectively. Results The mean age of 3206 participants in the Longevity Check-up and VIP surveys was 51.9 years (SD 15.6, range 18–98 years), and 1694 (52.8%) were women. Cross-sectional inspection suggests that both calf circumference and MAMC decline nonlinearly with age and the rate of decline varies by gender. These measures are stable until 50 years and then begin to decrease slightly with age, with the effect being more evident in men than in women. The main effect of the age category was observed in muscle strength and physical performance parameters. Muscle strength declined significantly after 45 years of age, both in men and women (P < .001). The muscle quality of the upper extremities, defined as handgrip strength divided by MAMC, declined significantly with aging, as well (P < .001). The time to complete the chair stand test was similar from 18 years to 40 to 44 years, and then a linear decline in performing the test across age groups was observed, with an increased time of more than 3 seconds, both in men and women (P < .001). Conclusions Muscle mass and strength curves may be used to extr
- Published
- 2017
40. Ovarian Cancer Management in the Oldest Old: Improving Outcomes and Tailoring Treatments
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Tortorella, Lucia, primary, Vizzielli, Giuseppe, primary, Fusco, Domenico, primary, Cho, William C., primary, Bernabei, Roberto, primary, Scambia, Giovanni, primary, and Colloca, Giuseppe, primary
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- 2017
- Full Text
- View/download PDF
41. Impact of disease duration and cardiovascular dysautonomia on hypertension in Parkinson's disease
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Vetrano, Davide L., primary, Pisciotta, Maria S., additional, Brandi, Vincenzo, additional, Lo Monaco, Maria R., additional, Laudisio, Alice, additional, Onder, Graziano, additional, Fusco, Domenico, additional, L′Angiocola, Paolo D., additional, Bentivoglio, Anna R., additional, Bernabei, Roberto, additional, and Zuccalà, Giuseppe, additional
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- 2016
- Full Text
- View/download PDF
42. Patient's Loss of Empathy Is Associated With Caregiver Burden
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Pomponi, Massimiliano, Ricciardi, Lucia, La Torre, Giuseppe, Fusco, Domenico, Morabito, Bruno, Ricciardi, Diego, Di Gioia, Annamaria, Bernabei, Roberto, Bentivoglio, Anna Rita, Bernabei, Roberto (ORCID:0000-0002-9197-004X), Bentivoglio, Anna Rita (ORCID:0000-0002-9663-095X), Pomponi, Massimiliano, Ricciardi, Lucia, La Torre, Giuseppe, Fusco, Domenico, Morabito, Bruno, Ricciardi, Diego, Di Gioia, Annamaria, Bernabei, Roberto, Bentivoglio, Anna Rita, Bernabei, Roberto (ORCID:0000-0002-9197-004X), and Bentivoglio, Anna Rita (ORCID:0000-0002-9663-095X)
- Abstract
Patients benefit from the presence of empathic caregivers (CGs). In this regard, empathy toward the patient is one of the clinical targets for improving patient outcomes. However, relatively little is known about the impact of patients' empathic responses on the CGs' burden. Among people living with Parkinson's disease (PwP), care partners play a major role. This study involved 28 spouse-patient couples. Empathy, stress burden, and mood disorders (such as anxiety and depression) were assessed over a 6-month period, before and after the reported intervention. Our observation points out that the improvement of patient empathy is necessary for a significant burden reduction among spouses caring for PwP.
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- 2016
43. Impact of disease duration and cardiovascular dysautonomia on hypertension in Parkinson's disease
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Vetrano, Davide Liborio, Pisciotta, Maria Stella, Brandi, Vincenzo, Lo Monaco, Maria Rita, Laudisio, Alice, Onder, Graziano, Fusco, Domenico, L. Angiocola, Paolo D, Bentivoglio, Anna Rita, Bernabei, Roberto, Zuccala', Giuseppe, Lo Monaco, Maria Rita (ORCID:0000-0002-1457-7981), Onder, Graziano (ORCID:0000-0003-3400-4491), Bentivoglio, Anna Rita (ORCID:0000-0002-9663-095X), Bernabei, Roberto (ORCID:0000-0002-9197-004X), Zuccala', Giuseppe (ORCID:0000-0002-2567-2220), Vetrano, Davide Liborio, Pisciotta, Maria Stella, Brandi, Vincenzo, Lo Monaco, Maria Rita, Laudisio, Alice, Onder, Graziano, Fusco, Domenico, L. Angiocola, Paolo D, Bentivoglio, Anna Rita, Bernabei, Roberto, Zuccala', Giuseppe, Lo Monaco, Maria Rita (ORCID:0000-0002-1457-7981), Onder, Graziano (ORCID:0000-0003-3400-4491), Bentivoglio, Anna Rita (ORCID:0000-0002-9663-095X), Bernabei, Roberto (ORCID:0000-0002-9197-004X), and Zuccala', Giuseppe (ORCID:0000-0002-2567-2220)
- Abstract
The authors evaluated the association of Parkinson's disease (PD) duration with hypertension, assessed by office measurements and 24-hour (ambulatory) monitoring, in 167 patients. Hypertension was evaluated through both office and ambulatory blood pressure (BP) measurements. Among participants (mean age 73.4±7.6 years; 35% women), the prevalence of hypertension was 60% and 69% according to office and ambulatory BP measurements, respectively (Cohen's k=0.61; P<.001). PD duration was inversely associated with hypertension as diagnosed by office measurements (odds ratio [OR], 0.92; 95% confidence interval [CI], 0.86-0.98) but not by ambulatory monitoring (OR, 0.94; 95% CI, 0.81-1.01). Ambulatory BP patterns showed higher nocturnal BP among patients with long-lasting disease. In conclusion, ambulatory BP monitoring improves the detection of hypertension by 15% in PD, compared with office evaluation. The likelihood of having hypertension does not decrease during the PD course; rather, BP pattern shifts towards nocturnal hypertension.
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- 2016
44. Nonlinear wave interactions for quasilinear hyperbolic 2×2 systems
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Currò, Carmela and Fusco, Domenico
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A reduction approach based upon the combined use of differential constraints theory and hodograph method is developed in order to determine closed form solutions for 2×2 hyperbolic quasilinear nonhomogeneous models. The problem of integrating the standard linear hodograph system associated with 2×2 homogeneous models is also considered. Along the lines of the proposed reduction approach different examples of 2×2 governing models are analyzed in order to highlight the flexibility of the provided solutions to describe hyperbolic wave processes.
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- 2013
45. Sarcopenia and mortality among older nursing home residents
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Landi, Francesco, Liperoti, Rosa, Fusco, Domenico, Mastropaolo, Simona, Quattrociocchi, Davide, Proia, Anna Silvia, Tosato, Matteo, Bernabei, Roberto, Onder, Graziano, Landi, Francesco (ORCID:0000-0002-3472-1389), Liperoti, Rosa (ORCID:0000-0003-3740-1687), Bernabei, Roberto (ORCID:0000-0002-9197-004X), Onder, Graziano (ORCID:0000-0003-3400-4491), Landi, Francesco, Liperoti, Rosa, Fusco, Domenico, Mastropaolo, Simona, Quattrociocchi, Davide, Proia, Anna Silvia, Tosato, Matteo, Bernabei, Roberto, Onder, Graziano, Landi, Francesco (ORCID:0000-0002-3472-1389), Liperoti, Rosa (ORCID:0000-0003-3740-1687), Bernabei, Roberto (ORCID:0000-0002-9197-004X), and Onder, Graziano (ORCID:0000-0003-3400-4491)
- Abstract
Sarcopenia has been indicated as a reliable marker of frailty and poor prognosis among the oldest individuals. At present, no data are available on sarcopenia in the nursing home population. The aim of the current study was to explore the relationship between sarcopenia and all-cause mortality in a population of elderly persons aged 70 years and older living in a nursing home in Italy.
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- 2012
46. Prevalence and risk factors of sarcopenia among nursing home older residents
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Landi, Francesco, Liperoti, Rosa, Fusco, Domenico, Mastropaolo, Simona, Quattrociocchi, Davide, Proia, Anna Silvia, Russo, Andrea, Bernabei, Roberto, Onder, Graziano, Landi, Francesco (ORCID:0000-0002-3472-1389), Liperoti, Rosa (ORCID:0000-0003-3740-1687), Bernabei, Roberto (ORCID:0000-0002-9197-004X), Onder, Graziano (ORCID:0000-0003-3400-4491), Landi, Francesco, Liperoti, Rosa, Fusco, Domenico, Mastropaolo, Simona, Quattrociocchi, Davide, Proia, Anna Silvia, Russo, Andrea, Bernabei, Roberto, Onder, Graziano, Landi, Francesco (ORCID:0000-0002-3472-1389), Liperoti, Rosa (ORCID:0000-0003-3740-1687), Bernabei, Roberto (ORCID:0000-0002-9197-004X), and Onder, Graziano (ORCID:0000-0003-3400-4491)
- Abstract
Sarcopenia has been indicated as a reliable marker of frailty and poor prognosis among the oldest individuals. At present, there are no data on sarcopenia in nursing home population. We evaluated the prevalence of sarcopenia and its association with functional and clinical status in a population of elderly persons aged 70 years and older living in nursing homes.
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- 2012
47. EXACT SOLUTIONS IN IDEAL CHROMATOGRAPHY VIA DIFFERENTIAL CONSTRAINTS METHOD.
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CURRÒ, CARMELA, FUSCO, DOMENICO, and MANGANARO, AND NATALE
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QUASILINEARIZATION , *CHROMATOGRAPHIC analysis , *BOUNDARY value problems - Abstract
A differential constraints analysis is worked out for a quasilinear hyperbolic system of first order PDEs written in terms of Riemann invariants which models multi- component ideal chromatography. Depending on the appended constraints, different exact solutions can be obtained which exhibit inherent wave features. Among others, there are determined generalized simple wave solutions which are parameterized by an arbitrary function so that they may also fit suitable boundary value problems. Within the latter framework an example is given. [ABSTRACT FROM AUTHOR]
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- 2015
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48. Epidemiology and genetics of microtia-anotia: a registry based study on over one million births
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Mastroiacovo, Pierpaolo, Corchia, C, Botto, Ld, Lanni, R, Zampino, Giuseppe, Fusco, Domenico, Zampino, Giuseppe (ORCID:0000-0003-3865-3253), Mastroiacovo, Pierpaolo, Corchia, C, Botto, Ld, Lanni, R, Zampino, Giuseppe, Fusco, Domenico, and Zampino, Giuseppe (ORCID:0000-0003-3865-3253)
- Abstract
The epidemiology and genetics of microtia-anotia (M-A) were studied using data collected from the Italian Multicentre Birth Defects Registry (IPIMC) from 1983 to 1992. Among 1,173, 794 births, we identified 172 with M-A, a rate of 1.46/10,000; 38 infants (22.1%) had anotia. Of the 172 infants, 114 (66.2%) had an isolated defect, 48 (27.9%) were multiformed infants (MMI) with M-A, and 10 (5.8%) had a well defined syndrome. The frequency of bilateral defects among non-syndromic cases was 12% compared to 50% of syndromic cases (p = 0.007). Among the MMI only holoprosencephaly was preferentially associated with M-A (four cases observed upsilon 0.7 expected, p = 0.005). No significant variations were identified in the prevalence of non-syndromic cases by geographical area (range 0.62-2.37/10,000 births) or by five month time periods (range 0.21-2.58/10,000 births), nor was there evidence of time trends. When M-A cases were compared to controls, we found that mothers with parity 1 had a higher risk of giving birth to an MMI with M-A, and that mothers with chronic maternal insulin dependent diabetes were at significantly higher risk for having a child with M-A. MMI with M-A had higher rates of prematurity, low birth weight, reduced intrauterine growth, and neonatal mortality than infants with isolated M-A and controls. Babies with isolated M-A had, on average, a lower birth weight than controls; the difference was higher for females. The analysis of pedigrees and familial cases suggests an autosomal dominant trait with variable expression and incomplete penetrance in a proportion of cases, or a multifactorial aetiology. Three cases had consanguineous parents, but the absence of M-A among previous sibs does not support autosomal recessive inheritance.
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- 1995
49. NONLINEAR WAVE INTERACTIONS FOR QUASILINEAR HYPERBOLIC 2 × 2 SYSTEMS.
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CURRò, CARMELA and FUSCO, DOMENICO
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- *
NONLINEAR waves , *HODOGRAPH equations , *HYPERBOLIC functions , *EQUATIONS in fluid mechanics , *LINEAR equations , *THEORY of wave motion , *WAVELETS (Mathematics) - Abstract
A reduction approach based upon the combined use of differential constraints theory and hodograph method is developed in order to determine closed form solutions for 2 × 2 hyperbolic quasilinear nonhomogeneous models. The problem of integrating the standard linear hodograph system associated with 2 × 2 homogeneous models is also considered. Along the lines of the proposed reduction approach different examples of 2×2 governing models are analyzed in order to highlight the flexibility of the provided solutions to describe hyperbolic wave processes. [ABSTRACT FROM AUTHOR]
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- 2013
- Full Text
- View/download PDF
50. Effects of antioxidant supplementation on the aging process.
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Fusco, Domenico, Colloca, Giuseppe, Lo Monaco, Maria Rita, and Cesari, Matteo
- Published
- 2007
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