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2. Abstract 10481: The Effect of Current Smoking on Platelet Reactivity Measures by Point-of-Care Methods in Patients Treated With and Without Clopidogrel

Author

Nicolau, Jose C, Salsoso, Rocio, Dalcoquio, Talia, Gurbel, Paul A, Tantry, Udaya, Giugliano, Robert, Nakashima, Carlos A, Franci, Andre, Rizzo, Paulo, menezes, fernando, Guardieiro, Bruno, Scanavini Filho, Marco Antonio, Ferrari, Aline G, Pereira, Cesar, Arantes, Flavia B, Barbosa, Carlos, Bertolin, Adriadne, and Furtado, Remo

Published
2022
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4. Platelet Reactivity in Patients With Acute Coronary Syndromes Awaiting Surgical Revascularization

Author

Nakashima, Carlos A.K., Dallan, Luis A.O., Lisboa, Luiz A.F., Jatene, Fabio B., Hajjar, Ludhmila A., Soeiro, Alexandre M., Furtado, Remo H.M., Dalçoquio, Talia F., Baracioli, Luciano M., Lima, Felipe G., Giraldez, Roberto R.C.V., Silva, Bianca A., Costa, Mateus S.S., Strunz, Celia M.C., Dallan, Luis R.P., Barbosa, Carlos J.D.G., Britto, Flavia A.B., Farkouh, Michael E., Gurbel, Paul A., and Nicolau, Jose C.

Published
2021
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9. Long-term outcomes among stable post-acute myocardial infarction patients living in rural versus urban areas: insights from the prospective, observational TIGRIS registry

Author

Nicolau, Jose Carlos, primary, Owen, Ruth, additional, Furtado, Remo H M, additional, Goodman, Shaun G, additional, Granger, Christopher B, additional, Cohen, Mauricio G, additional, Westermann, Dirk, additional, Yasuda, Satoshi, additional, Simon, Tabassome, additional, Hedman, Katarina, additional, Hunt, Phillip R, additional, Brieger, David B, additional, and Pocock, Stuart J, additional

Published
2023
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12. Effects of exercise on platelet reactivity after myocardial infarction: a randomized clinical trial.

Author

Falcão Dalçóquio, Talia, Alves dos Santos, Mayara, Silva Alves, Leandro, Brito Arantes, Flávia Bittar, Ferreira-Santos, Larissa, Pinto Brandão Rondon, Maria Urbana, Furtado, Remo Holanda M., Ferrari, Aline Gehlen, Rizzo, Paulo Roberto Genestreti, Salsoso, Rocio, Franci, Andre, Moreira Baracioli, Luciano, de Nazare Nunes Alves, Maria Janieire, Eduardo Negrão, Carlos, and Carlos Nicolau, José

Subjects
MYOCARDIAL infarction, CLINICAL trials, BLOOD platelets, EXERCISE tests, CARDIOVASCULAR diseases risk factors, ADENOSINE diphosphate
Abstract

Exercise training (ET) can lower platelet reactivity in patients with cardiovascular risk factors. However, the effects of ET on platelet reactivity in higher-risk patients is unknown. The aim of this study was to evaluate the effects of ET on platelet reactivity in patients with recent myocardial infarction (MI). Ninety patients were randomly assigned 1 month post-MI to the intervention (patients submitted to a supervised ET program) or control group. All patients were on dual antiplatelet therapy (DAPT). Platelet reactivity by VerifyNow-P2Y12 (measured by P2Y12 reaction units - PRUs) test was determined at baseline and at the end of 14 ± 2 weeks of follow-up at rest (primary endpoint), and multiplate electrode aggregometry (MEA) adenosine diphosphate (ADP) and aspirin (ASPI) tests were performed immediately before and after the maximal cardiopulmonary exercise test (CPET) at the same time points (secondary endpoints). Sixty-five patients (mean age 58.9 ± 10 years; 73.8% men; 60% ST elevation MI) completed follow-up (control group, n = 31; intervention group, n = 34). At the end of the follow-up, the mean platelet reactivity was 172.8 ± 68.9 PRUs and 166.9 ± 65.1 PRUs for the control and intervention groups, respectively (p = .72). Platelet reactivity was significantly increased after the CPET compared to rest at the beginning and at the end of the 14-week follow-up (among the intervention groups) by the MEA-ADP and MEA-ASPI tests (p < .01 for all analyses). In post-MI patients on DAPT, 14 weeks of supervised ET did not reduce platelet reactivity. Moreover, platelet reactivity was increased after highintensity exercise (ClinicalTrials.gov: NCT02958657; https://clinicaltrials.gov/ct2/show/NCT02958657). [ABSTRACT FROM AUTHOR]

Published
2023
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13. Dapagliflozin and Cardiac, Kidney, and Limb Outcomes in Patients With and Without Peripheral Artery Disease in DECLARE-TIMI 58

Author

Bonaca, Marc P., Wiviott, Stephen D., Zelniker, Thomas A., Mosenzon, Ofri, Bhatt, Deepak L., Leiter, Lawrence A., McGuire, Darren K., Goodrich, Erica L., De Mendonca Furtado, Remo Holanda, Wilding, John P.H., Cahn, Avivit, Gause-Nilsson, Ingrid A.M., Johanson, Per, Fredriksson, Martin, Johansson, Peter A., Langkilde, Anna Maria, Raz, Itamar, and Sabatine, Marc S.

Published
2020
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14. Effect of Dapagliflozin on Atrial Fibrillation in Patients With Type 2 Diabetes Mellitus: Insights From the DECLARE-TIMI 58 Trial

Author

Zelniker, Thomas A., Bonaca, Marc P., Furtado, Remo H.M., Mosenzon, Ofri, Kuder, Julia F., Murphy, Sabina A., Bhatt, Deepak L., Leiter, Lawrence A., McGuire, Darren K., Wilding, John P.H., Budaj, Andrzej, Kiss, Robert G., Padilla, Francisco, Gause-Nilsson, Ingrid, Langkilde, Anna Maria, Raz, Itamar, Sabatine, Marc S., and Wiviott, Stephen D.

Published
2020
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15. Anticoagulation Strategies in Non-Critically Ill Patients Hospitalized with COVID-19: A Randomized Clinical Trial

Author

Stone, Gregg W., primary, Farkouh, Michael E., additional, Lala, Anuradha, additional, Tinuoye, Elizabeth, additional, Dressler, Ovidiu, additional, Moreno, Pedro R., additional, Palacios, Igor F., additional, Goodman, Shaun G., additional, Esper, Rodrigo B., additional, Abizaid, Alexandre, additional, Varade, Deepak, additional, Betancur, Juan F., additional, Ricalde, Alejandro, additional, Payro, Gerardo, additional, Castellano, José María, additional, Hung, Ivan FN, additional, Nadkarni, Girish N., additional, Giustino, Gennaro, additional, Godoy, Lucas C., additional, Feinman, Jason, additional, Camaj, Anton, additional, Bienstock, Solomon W., additional, Furtado, Remo H.M., additional, Granada, Carlos, additional, Bustamante, Jessica, additional, Peyra, Carlos, additional, Contreras, Johanna, additional, Owen, Ruth, additional, Bhatt, Deepak L., additional, Pocock, Stuart J., additional, Fuster, Valentin, additional, Lala, Anu, additional, Paul, Jonathan, additional, Pyo, Robert, additional, Baber, Usman, additional, Suh, Jason, additional, Saggar, Suraj, additional, Srivatsa, Sanjay, additional, Coylewright, Megan, additional, Chapparo, Sandra, additional, Melo, Jairo, additional, Keller, Norma, additional, Llanos, Alexander, additional, Chiu, Edwin, additional, Fahid, Ibrahim, additional, The, Angela, additional, Esper, Rodrigo Barbosa, additional, Ghetti Cabral, Ricardo Mauro, additional, Pompilio, Mauricio Antonio, additional, Cordeiro de Paula, Leonardo Jorge, additional, Airton de Arruda, Jose, additional, Filho, Roberto Kalil, additional, Faillace, Bruno, additional, Avancini Caramori, Paulo Ricardo, additional, da Silva Junior, Delcio Goncalves, additional, Neto, Eduardo Kowalski, additional, Nascif, Gibran Bhering, additional, Baccaro, Bruno Mendonca, additional, Cesar Cavalcanti, Rafael Rebelo, additional, Moraes Junior, Joao Batista, additional, Betancur, Juan Felipe, additional, Echeverri, Dario, additional, Beltran, Fernan Mendoza, additional, Renowistki Zabarain, Carlos Ramon, additional, Martinez Bula, Eduardo Antonio, additional, Fernandez, Angela María, additional, Melendez Flórez, Hector Julio, additional, Osorio, Wilder Castano, additional, Clavijo Moldón, Absalon Antonio, additional, Moreno, Antonio Figueredo, additional, Wong, Chun-Ka, additional, Varma, Madhumati, additional, Khanna, Aman, additional, Nikam, Prasad, additional, Bangi, Ashpak, additional, Gupta, Jugal Bihari, additional, Bhandari, Sudhir, additional, Sengupta, Shantanu, additional, Bhattacharya, Meenakshi, additional, Mehta, Nihar, additional, Aggarwal, Deepesh, additional, Uppe, Abhay, additional, Calcagno, Andrea, additional, Querini, Patrizia Rovere, additional, Narducci, Maria Lucia, additional, Guerrero, Jessica Paola, additional, Elizalde, Ivan, additional, Bello, Hector Herrera, additional, Cabrera, Otto Tavera, additional, Portano, Julieta Morales, additional, Riedel, Patricia Aubanel, additional, Llamas Esperon, Guillermo Antonio, additional, Guarena Casillas, Jorge Armando, additional, Azpiri, Jose Ramon, additional, Calvillo, Jorge Carrillo, additional, Lopez, Roberto Dominguez, additional, Barreto, Nancy Quezada, additional, Jaramillo, Ricardo, additional, Sokolski, Mateusz, additional, Fernandez, Paula Villares, additional, Moya Mateo, Eva Maria, additional, Varona Arche, Jose Felipe, additional, Mateo, Patricia Fanlo, additional, and Garcia Lomas, Mercedes Villareal, additional

Published
2023
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16. Effect of Dapagliflozin on Heart Failure and Mortality in Type 2 Diabetes Mellitus

Author

Kato, Eri T., Silverman, Michael G., Mosenzon, Ofri, Zelniker, Thomas A., Cahn, Avivit, Furtado, Remo H.M., Kuder, Julia, Murphy, Sabina A., Bhatt, Deepak L., Leiter, Lawrence A., McGuire, Darren K., Wilding, John P.H., Bonaca, Marc P., Ruff, Christian T., Desai, Akshay S., Goto, Shinya, Johansson, Peter A., Gause-Nilsson, Ingrid, Johanson, Per, Langkilde, Anna Maria, Raz, Itamar, Sabatine, Marc S., and Wiviott, Stephen D.

Published
2019
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17. Dapagliflozin and Cardiovascular Outcomes in Patients With Type 2 Diabetes Mellitus and Previous Myocardial Infarction: Subanalysis From the DECLARE-TIMI 58 Trial

Author

Furtado, Remo H.M., Bonaca, Marc P., Raz, Itamar, Zelniker, Thomas A., Mosenzon, Ofri, Cahn, Avivit, Kuder, Julia, Murphy, Sabina A., Bhatt, Deepak L., Leiter, Lawrence A., McGuire, Darren K., Wilding, John P.H., Ruff, Christian T., Nicolau, Jose C., Gause-Nilsson, Ingrid A.M., Fredriksson, Martin, Langkilde, Anna Maria, Sabatine, Marc S., and Wiviott, Stephen D.

Published
2019
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18. Comparison of the Effects of Glucagon-Like Peptide Receptor Agonists and Sodium-Glucose Cotransporter 2 Inhibitors for Prevention of Major Adverse Cardiovascular and Renal Outcomes in Type 2 Diabetes Mellitus: Systematic Review and Meta-Analysis of Cardiovascular Outcomes Trials

Author

Zelniker, Thomas A., Wiviott, Stephen D., Raz, Itamar, Im, KyungAh, Goodrich, Erica L., Furtado, Remo H.M., Bonaca, Marc P., Mosenzon, Ofri, Kato, Eri T., Cahn, Avivit, Bhatt, Deepak L., Leiter, Lawrence A., McGuire, Darren K., Wilding, John P.H., and Sabatine, Marc S.

Published
2019
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19. Long‐term mortality after acute coronary syndromes among patients with normal, mildly reduced, or reduced ejection fraction

Author

Furtado, Remo H.M., primary, Juliasz, Marcela G., additional, Chiu, Felipe Y.J., additional, Bastos, Livia B.C., additional, Dalcoquio, Talia F., additional, Lima, Felipe G., additional, Rosa, Renato, additional, Caporrino, Cesar A., additional, Bertolin, Adriadne, additional, Genestreti, Paulo R.R., additional, Ribeiro, Andre S., additional, Andrade, Maria Carolina, additional, Giraldez, Roberto R.C.V., additional, Baracioli, Luciano M., additional, Zelniker, Thomas A., additional, and Nicolau, Jose C., additional

Published
2022
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20. Effects of DPP4 Inhibitor in Platelet Reactivity and Other Cardiac Risk Markers in Patients with Type 2 Diabetes and Acute Myocardial Infarction

Author

Genestreti, Paulo R. Rizzo, primary, Furtado, Remo H. M., additional, Salsoso, Rocio, additional, Dalçóquio, Talia F., additional, Franci, Andre, additional, Menezes, Fernando R., additional, Caporrino, Cesar, additional, Ferrari, Aline G., additional, Nakashima, Carlos A. K., additional, Scanavini Filho, Marco A., additional, Lima, Felipe G., additional, Giraldez, Roberto R. C. V., additional, Baracioli, Luciano M., additional, and Nicolau, Jose C., additional

Published
2022
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21. Randomized, Placebo-Controlled Phase 2b Study to Evaluate the Safety and Efficacy of Recombinant Human Lecithin Cholesterol Acyltransferase in Acute ST-Segment–Elevation Myocardial Infarction: Results of REAL-TIMI 63B

Author

Bonaca, Marc P., primary, Morrow, David A., additional, Bergmark, Brian A., additional, Berg, David D., additional, Lima, Joao A.C., additional, Hoffmann, Udo, additional, Kato, Yoko, additional, Lu, Michael T., additional, Kuder, Julia, additional, Murphy, Sabina A., additional, Spinar, Jindrich, additional, Oude Ophuis, Ton, additional, Kiss, Róbert G., additional, Lopez-Sendon, Jose, additional, Averkov, Oleg, additional, Wheatcroft, Stephen B., additional, Kubica, Jacek, additional, Carlos Nicolau, Jose, additional, Furtado, Remo H.M., additional, Abuhatzira, Liron, additional, Hirshberg, Boaz, additional, Omar, Sami A., additional, Vavere, Andrea L., additional, Chang, Yi-Ting, additional, George, Richard T., additional, and Sabatine, Marc S., additional

Published
2022
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22. Influenza vaccination strategy in acute coronary syndromes: the VIP-ACS trial

Author

Fonseca, Henrique Andrade R, primary, Furtado, Remo Holanda M, additional, Zimerman, André, additional, Lemos, Pedro A, additional, Franken, Marcelo, additional, Monfardini, Frederico, additional, Pedrosa, Rodrigo P, additional, Patriota, Rodrigo de Lemos S, additional, Passos, Luiz Carlos S, additional, Dall’Orto, Frederico Toledo C, additional, Hoffmann Filho, Conrado R, additional, Nascimento, Bruno Ramos, additional, Baldissera, Felipe A, additional, Pereira, Cesar Augusto C, additional, Caramori, Paulo Ricardo A, additional, de Andrade, Pedro Beraldo, additional, Esteves, Carlos, additional, Salim, Elke Ferreira, additional, da Silva, Jefferson Henrique, additional, Pedro, Izabela Chave, additional, Silva, Mariana Castaldi R, additional, de Pedri, Ewerton Hernandes, additional, Carioca, Ana Carla R D, additional, de Piano, Luciana Pereira A, additional, Albuquerque, Camila Santos N, additional, Moia, Diogo D F, additional, Momesso, Roberta Grazzielli R A P, additional, Machado, Felipe P, additional, Damiani, Lucas P, additional, Soares, Ronaldo Vicente P, additional, Schettino, Guilherme P, additional, Rizzo, Luiz V, additional, Nicolau, José Carlos, additional, and Berwanger, Otávio, additional

Published
2022
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23. Efficacy and Safety of Dapagliflozin in Type 2 Diabetes According to Baseline Blood Pressure: Observations From DECLARE-TIMI 58 Trial

Author

Furtado, Remo H.M., primary, Raz, Itamar, additional, Goodrich, Erica L., additional, Murphy, Sabina A., additional, Bhatt, Deepak L., additional, Leiter, Lawrence A., additional, McGuire, Darren K., additional, Wilding, John P.H., additional, Aylward, Philip, additional, Dalby, Anthony J, additional, Dellborg, Mikael, additional, Dimulescu, Doina, additional, Nicolau, José C., additional, Oude Ophuis, Anthonius J.M., additional, Cahn, Avivit, additional, Mosenzon, Ofri, additional, Gause-Nilsson, Ingrid, additional, Langkilde, Anna Maria, additional, Sabatine, Marc S., additional, and Wiviott, Stephen D., additional

Published
2022
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24. Dapagliflozin and Kidney Outcomes in Hospitalized Patients with COVID-19 Infection

Author

Heerspink, Hiddo J.L., primary, Furtado, Remo H.M., additional, Berwanger, Otavio, additional, Koch, Gary G., additional, Martinez, Felipe, additional, Mukhtar, Omar, additional, Verma, Subodh, additional, Gasparyan, Samvel B., additional, Tang, Fengming, additional, Windsor, Sheryl L., additional, de Souza-Dantas, Vicente Cés, additional, del Sueldo, Mildren, additional, Frankel, Robert, additional, Javaheri, Ali, additional, Maldonado, Rafael A., additional, Morse, Caryn, additional, Mota-Gomes, Marco, additional, Shemin, Douglas, additional, Silva, Osvaldo Lourenço, additional, Tognon, Alexandre Pereira, additional, Twahirwa, Marcel, additional, Buenconsejo, Joan, additional, Esterline, Russell, additional, Oscarsson, Jan, additional, Ambery, Philip, additional, Langkilde, Anna Maria, additional, and Kosiborod, Mikhail N., additional

Published
2022
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25. Long‐term mortality after acute coronary syndromes among patients with normal, mildly reduced, or reduced ejection fraction.

Author

Furtado, Remo H.M., Juliasz, Marcela G., Chiu, Felipe Y.J., Bastos, Livia B.C., Dalcoquio, Talia F., Lima, Felipe G., Rosa, Renato, Caporrino, Cesar A., Bertolin, Adriadne, Genestreti, Paulo R.R., Ribeiro, Andre S., Andrade, Maria Carolina, Giraldez, Roberto R.C.V., Baracioli, Luciano M., Zelniker, Thomas A., and Nicolau, Jose C.

Subjects
ACUTE coronary syndrome, VENTRICULAR ejection fraction, MORTALITY risk factors, HOSPITAL admission & discharge
Abstract

Aims: Left ventricular ejection fraction (LVEF) ≤ 40% is a well‐established risk factor for mortality after acute coronary syndromes (ACS). However, the long‐term prognostic impact of mildly reduced ejection fraction (EF) (LVEF 41–49%) after ACS remains less clear. Methods and results: This was a retrospective study enrolling patients admitted with ACS included in a single‐centre databank. LVEF was assessed by echocardiography during index hospitalization. Patients were divided in the following categories according to LVEF: normal (LVEF ≥ 50%), mildly reduced (LVEF 41–49%), and reduced (LVEF ≤ 40%). The endpoint of interest was all‐cause death after hospital discharge. A multivariable Cox model was used to adjust for confounders. A total of 3200 patients were included (1952 with normal EF, 375 with mildly reduced EF, and 873 with reduced EF). The estimated cumulative incidence rates of mortality at 10 years for patients with normal, mildly reduced, and reduced EF were 24.8%, 33.5%, and 41.3%, respectively. After adjustments, the presence of reduced EF was associated with higher mortality compared with normal EF [adjusted hazard ratio (HR) 1.64; 95% confidence interval (CI) 1.36–1.96; P < 0.001], as was mildly reduced EF compared with normal EF (adjusted HR 1.33; 95% CI 1.05–1.68; P = 0.019). The presence of reduced EF was not associated with a statistically significantly higher mortality compared with mildly reduced EF (adjusted HR 1.23; 95% CI 0.96–1.57; P = 0.095). Conclusions: In patients with ACS, mildly reduced EF measured in the acute phase was associated with higher long‐term mortality compared with patients with normal EF. These data emphasize the importance of anti‐remodelling therapies for ACS patients who have LVEF in the mildly reduced range. [ABSTRACT FROM AUTHOR]

Published
2023
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26. Effect of Evolocumab in Patients With Prior Percutaneous Coronary Intervention

Author

Furtado, Remo H.M., primary, Fagundes, Antônio Aurélio, additional, Oyama, Kazuma, additional, Zelniker, Thomas A., additional, Tang, Minao, additional, Kuder, Julia F., additional, Murphy, Sabina A., additional, Hamer, Andrew, additional, Wang, Huei, additional, Keech, Anthony C., additional, Giugliano, Robert P., additional, Sabatine, Marc S., additional, and Bergmark, Brian A., additional

Published
2022
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27. P2Y12 inhibitor versus aspirin monotherapy for secondary prevention of cardiovascular events: meta-analysis of randomized trials

Author

Aggarwal, Devika, primary, Bhatia, Kirtipal, additional, Chunawala, Zainali S, additional, Furtado, Remo H M, additional, Mukherjee, Debabrata, additional, Dixon, Simon R, additional, Jain, Vardhmaan, additional, Arora, Sameer, additional, Zelniker, Thomas A, additional, Navarese, Eliano P, additional, Mishkel, Gregory J, additional, Lee, Cheong J, additional, Banerjee, Subhash, additional, Bangalore, Sripal, additional, Levisay, Justin P, additional, Bhatt, Deepak L, additional, Ricciardi, Mark J, additional, and Qamar, Arman, additional

Published
2022
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28. Abstract 12524: Very Long-term Mortality After St Elevation Myocardial Infarction (stemi) Complicated By Cardiogenic Shock

Author

Kanhouche, Gabriel, primary, Nicolau, Jose, additional, Falcão Dalçoquio, Talia, additional, Marchi, Mauricio Felippi de Sa, additional, Giraldez, Roberto R, additional, Furtado, Remo, additional, Baracioli, Luciano, additional, Kalil Filho, Roberto, additional, de Brito Junior, Fabio, additional, Abizaid, Alexandre, additional, and Ribeiro, Henrique, additional

Published
2021
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29. Abstract 10724: Long-Term Mortality After Acute Coronary Syndromes Among Patients with Normal, Mid-Range or Low Ejection Fraction

Author

Furtado, Remo, primary, Juliasz, Marcela G, additional, CHIU, FELIPE Y, additional, Bastos, Livia B, additional, Dalcoquio, Talia F, additional, Lima, Felipe G, additional, Rosa, Renato, additional, Caporrino, Cesar A, additional, Bertolin, Adriadne, additional, Soffiatti, Carla, additional, Ribeiro, Andre S, additional, Andrade, Maria C, additional, Giraldez, Roberto, additional, Baracioli, Luciano, additional, and Nicolau, Jose C, additional

Published
2021
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30. Abstract 13729: Monotherapy With a P2Y12 Inhibitor versus Aspirin for Secondary Prevention of Atherosclerotic Cardiovascular Disease (ASCVD) Events: A Meta-Analysis of Randomized Trials

Author

Chunawala, Zainali, primary, Aggarwal, Devika, additional, Bhatia, Kirtipal S, additional, jain, vardhmaan, additional, Mukherjee, Debabrata, additional, Baber, Usman, additional, Bangalore, Sripal, additional, NAVARESE, ELIANO, additional, Levisay, Justin p, additional, Mishkel, Gregory, additional, Ricciardi, Mark, additional, Vaduganathan, Muthiah, additional, Furtado, Remo, additional, Zelniker, Thomas A, additional, and Qamar, Arman, additional

Published
2021
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31. Abstract 13782: Platelet Aggregation and Adenosine Levels Among Patients With Stable Chronic Coronary Artery Disease Taking Ticagrelor or Prasugrel

Author

Menezes, Fernando, primary, Furtado, Remo, additional, Dalçóquio, Talia, additional, Genestreti, Paulo, additional, Bertolin, Adriadne, additional, Baracioli, Luciano, additional, Scanavini, Marco, additional, oliveira, beatriz, additional, Franci, Andre, additional, Silva, Marli, additional, Roggerio, Alessandra, additional, Ferrari, Aline G, additional, Lima, Viviane, additional, Pereira, Cesar, additional, Nakashima, Carlos A, additional, Strunz, Celia, additional, Salsoso, Rocio, additional, Soffiatti, Carla, additional, Baldo, Vanessa, additional, and Nicolau, Jose C, additional

Published
2021
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32. Effects of exercise on platelet reactivity after myocardial infarction: a randomized clinical trial.

Author

Dalçóquio, Talia Falcão, Alves dos Santos, Mayara, Silva Alves, Leandro, Bittar Brito Arantes, Flávia, Ferreira-Santos, Larissa, Pinto Brandão Rondon, Maria Urbana, Furtado, Remo Holanda M, Gehlen Ferrari, Aline, Genestreti Rizzo, Paulo Roberto, Salsoso, Rocio, Franci, Andre, Moreira Baracioli, Luciano, de Nazare Nunes Alves, Maria Janieire, Negrão, Carlos Eduardo, and Nicolau, José Carlos

Subjects
MYOCARDIAL infarction, CLINICAL trials, BLOOD platelets, CARDIOVASCULAR diseases risk factors, EXERCISE tests, PLATELET aggregation inhibitors
Abstract

Exercise training (ET) can lower platelet reactivity in patients with cardiovascular risk factors. However, the effects of ET on platelet reactivity in higher-risk patients is unknown. The aim of this study was to evaluate the effects of ET on platelet reactivity in patients with recent myocardial infarction (MI). Ninety patients were randomly assigned 1 month post-MI to the intervention (patients submitted to a supervised ET program) or control group. All patients were on dual antiplatelet therapy (DAPT). Platelet reactivity by VerifyNow-P2Y12 (measured by P2Y12 reaction units – PRUs) test was determined at baseline and at the end of 14 ± 2 weeks of follow-up at rest (primary endpoint), and multiplate electrode aggregometry (MEA) adenosine diphosphate (ADP) and aspirin (ASPI) tests were performed immediately before and after the maximal cardiopulmonary exercise test (CPET) at the same time points (secondary endpoints). Sixty-five patients (mean age 58.9 ± 10 years; 73.8% men; 60% ST elevation MI) completed follow-up (control group, n = 31; intervention group, n = 34). At the end of the follow-up, the mean platelet reactivity was 172.8 ± 68.9 PRUs and 166.9 ± 65.1 PRUs for the control and intervention groups, respectively (p =.72). Platelet reactivity was significantly increased after the CPET compared to rest at the beginning and at the end of the 14-week follow-up (among the intervention groups) by the MEA-ADP and MEA-ASPI tests (p <.01 for all analyses). In post-MI patients on DAPT, 14 weeks of supervised ET did not reduce platelet reactivity. Moreover, platelet reactivity was increased after high-intensity exercise (ClinicalTrials.gov: NCT02958657; ). What is the context? Platelet reactivity is reduced after exercise training in healthy individuals and patients with cardiovascular risk factors, but the effect in higher-risk patients is unknown. High-intensity exercise in untrained individuals increases platelet reactivity. The effect of dual antiplatelet therapy in inhibiting exercise-induced hyperreactivity is poorly understood. What's new? Exercise training did not reduce platelet reactivity in post-myocardial infarction patients. High-intensity exercise increased platelet reactivity in post-myocardial infarction patients on dual antiplatelet therapy. Exercise training did not attenuate the exercise-induced increase in platelet reactivity. What's the impact? The study suggests that strenuous exercise, if indicated, should be applied carefully to patients with high risk of recurrent ischemic events, even if on optimal medical therapy and after being trained. [ABSTRACT FROM AUTHOR]

Published
2023
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33. Diretrizes da Sociedade Brasileira de Cardiologia sobre Angina Instável e Infarto Agudo do Miocárdio sem Supradesnível do Segmento ST – 2021

Author

Nicolau, José Carlos, primary, Feitosa, Gilson Soares, additional, Petriz, João Luiz, additional, Furtado, Remo Holanda de Mendonça, additional, Précoma, Dalton Bertolim, additional, Lemke, Walmor, additional, Lopes, Renato Delascio, additional, Timerman, Ari, additional, Marin, José A., additional, Bezerra, Luiz, additional, Gomes, Bruno Ferraz de Oliveira, additional, Santos, Eduardo Cavalcanti Lapa, additional, Piegas, Leopoldo Soares, additional, Soeiro, Alexandre de Matos, additional, Negri, Alexandre Jorge de Andrade, additional, Franci, Andre, additional, Markman, Brivaldo, additional, Baccaro, Bruno Mendonça, additional, Montenegro, Carlos Eduardo Lucena, additional, Rochitte, Carlos Eduardo, additional, Barbosa, Carlos José Dornas Gonçalves, additional, Virgens, Cláudio Marcelo Bittencourt das, additional, Stefanini, Edson, additional, Manenti, Euler Roberto Fernandes, additional, Lima, Felipe Gallego, additional, Monteiro, Francisco das Chagas, additional, Correa, Harry, additional, Pena, Henrique Patrus Mundim, additional, Pinto, Ibraim Masciarelli Francisco, additional, Falcão, João Luiz de Alencar Araripe, additional, Sena, Joberto Pinheiro, additional, Peixoto, José Maria, additional, Souza, Juliana Ascenção de, additional, Silva, Leonardo Sara da, additional, Maia, Lilia Nigro, additional, Ohe, Louis Nakayama, additional, Baracioli, Luciano Moreira, additional, Dallan, Luís Alberto de Oliveira, additional, Dallan, Luis Augusto Palma, additional, Mattos, Luiz Alberto Piva e, additional, Bodanese, Luiz Carlos, additional, Ritt, Luiz Eduardo Fonteles, additional, Canesin, Manoel Fernandes, additional, Rivas, Marcelo Bueno da Silva, additional, Franken, Marcelo, additional, Magalhães, Marcos José Gomes, additional, Oliveira, Múcio Tavares de, additional, Filgueiras, Nivaldo Menezes, additional, Dutra, Oscar Pereira, additional, Coelho, Otávio Rizzi, additional, Leães, Paulo Ernesto, additional, Rossi, Paulo Roberto Ferreira, additional, Soares, Paulo Rogério, additional, Lemos, Pedro Alves, additional, Farsky, Pedro Silvio, additional, Cavalcanti, Rafael Rebêlo C., additional, Alves, Renato Jorge, additional, Kalil, Renato Abdala Karam, additional, Esporcatte, Roberto, additional, Marino, Roberto Luiz, additional, Giraldez, Roberto Rocha Corrêa Veiga, additional, Meneghelo, Romeu Sérgio, additional, Lima, Ronaldo de Souza Leão, additional, Ramos, Rui Fernando, additional, Falcão, Sandra Nivea dos Reis Saraiva, additional, Dalçóquio, Talia Falcão, additional, Lemke, Viviana de Mello Guzzo, additional, Chalela, William Azem, additional, and Mathias, Wilson, additional

Published
2021
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34. SAFETY AND EFFICACY OF DPP4 INHIBITORS IN ACUTE MYOCARDIAL INFARCTION: A BIOMARKER DRIVEN DOUBLE-BLINDED RANDOMIZED CONTROLLED TRIAL

Author

Genestreti, Paulo Rizzo, primary, Furtado, Remo, additional, Salsoso, Rocío, additional, Dalcoquio, Talia, additional, Nakashima, Carlos, additional, Lima, Viviane, additional, Colodetti, Raiza, additional, Ferrari, Aline, additional, Franci, Andre, additional, Menezes, Fernando, additional, Baracioli, Luciano, additional, and Nicolau, Jose, additional

Published
2021
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35. HIGH-DENSITY LIPOPROTEIN FUNCTION IN PATIENTS WITH TYPE 2 DIABETES: DIFFERENCES BETWEEN THE ACUTE AND CHRONIC PHASES OF CORONARY ARTERY DISEASE

Author

Genestreti, Paulo Rizzo, primary, Freitas, Fatima R., additional, Furtado, Remo, additional, Rodriguez, Rocio Salsoso, additional, Dalcoquio, Talia, additional, Tavoni, Thauany, additional, Nakashima, Carlos, additional, Ferrari, Aline Gehlen, additional, Colodetti, Raiza, additional, Menezes, Fernando, additional, Lima, Viviane, additional, Baracioli, Luciano, additional, Maranhao, Raul C., additional, and Nicolau, Jose, additional

Published
2021
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37. INFLUENCE OF HEALTH INSURANCE ON LONG-TERM ADHERENCE TO STATINS AND BETA-BLOCKERS AFTER ACUTE CORONARY SYNDROMES

Author

Nicolau, Jose Carlos, primary, Salsoso, Rocío, additional, Dalcoquio, Talia, additional, Genestreti, Paulo, additional, Franci, Andre, additional, Ferrari, Aline, additional, Bertolin, Adriadne, additional, Lara, Livia, additional, Juliasz, Marcela, additional, Pereira, Cesar, additional, Lima, Felipe, additional, Baracioli, Luciano, additional, Giraldez, Roberto, additional, and Furtado, Remo, additional

Published
2021
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38. BIOMARKER PREDICTION OF MAJOR CORONARY EVENTS AND COMPLEX REVASCULARIZATION PROCEDURES IN PATIENTS WITH STABLE ATHEROSCLEROSIS

Author

Fagundes, Antonio, primary, Morrow, David, additional, Oyama, Kazuma, additional, Furtado, Remo, additional, Zelniker, Thomas, additional, Tang, Minao, additional, Kuder, Julia, additional, Murphy, Sabina A., additional, Hamer, Andrew, additional, Keech, Anthony, additional, Sever, Peter, additional, Giugliano, Robert, additional, Sabatine, Marc, additional, and Bergmark, Brian, additional

Published
2021
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39. Diabetes association with self-reported health, resource utilization, and prognosis post-myocardial infarction

Author

Nicolau, José C, Brieger, David, Owen, Ruth, Furtado, Remo HM, Goodman, Shaun G, Cohen, Mauricio G, Simon, Tabassome, Westermann, Dirk, Granger, Christopher B, Grieve, Richard, Yasuda, Satoshi, Chen, Jiyan, Hedman, Katarina, Mellström, Carl, Brandrup-Wognsen, Gunnar, and Pocock, Stuart J

Abstract

BACKGROUND: Diabetes mellitus (DM) is associated with increased cardiovascular (CV) risk. We compared health-related quality of life (HRQoL), healthcare resource utilization (HRU), and clinical outcomes of stable post-myocardial infarction (MI) patients with and without DM. HYPOTHESIS: In post-MI patients, DM is associated with worse HRQoL, increased HRU, and worse clinical outcomes. METHODS: The prospective, observational long-term risk, clinical management, and healthcare Resource utilization of stable coronary artery disease study obtained data from 8968 patients aged ≥50 years 1 to 3 years post-MI (369 centers; 25 countries). Patients with ≥1 of the following risk factors were included: age ≥65 years, history of a second MI >1 year before enrollment, multivessel coronary artery disease, creatinine clearance ≥15 and

Published
2020

40. Associação entre Terapia com Estatinas e Menor Incidência de Hiperglicemia em Pacientes Internados com Síndromes Coronarianas Agudas

Author

Furtado, Remo Holanda de Mendonça, primary, Genestreti, Paulo Rizzo, additional, Dalçóquio, Talia F., additional, Baracioli, Luciano Moreira, additional, Lima, Felipe Galego, additional, Franci, André, additional, Giraldez, Roberto R. C. V., additional, Menezes, Fernando R., additional, Ferrari, Aline Gehlen, additional, Lima, Viviane Moreira, additional, Pereira, Cesar A. C., additional, Nakashima, Carlos Alberto Kenji, additional, Salsoso, Rocio, additional, Godoy, Lucas Colombo, additional, and Nicolau, José C., additional

Published
2021
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41. Factors associated with actively working in the very long-term following acute coronary syndrome

Author

Nicolau, Jose C., primary, Furtado, Remo H.M., additional, Dalçóquio, Talia F., additional, Lara, Livia M., additional, Juliasz, Marcela G., additional, Ferrari, Aline G., additional, Nakashima, Carlos A.K., additional, Franci, Andre, additional, Pereira, Cesar A.C., additional, Lima, Felipe G., additional, Giraldez, Roberto R., additional, Salsoso, Rocío, additional, Baracioli, Luciano M., additional, and Goodman, Shaun, additional

Published
2021
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42. Caffeinated Beverage Intake, Dyspnea With Ticagrelor, and Cardiovascular Outcomes: Insights From the PEGASUS‐TIMI 54 Trial

Author

Furtado, Remo H. M., primary, Venkateswaran, Ramkumar V., additional, Nicolau, Jose C., additional, Gurmu, Yared, additional, Bhatt, Deepak L., additional, Storey, Robert F., additional, Steg, P. Gabriel, additional, Magnani, Giuglia, additional, Goto, Shinya, additional, Dellborg, Mikael, additional, Kamensky, Gabriel, additional, Isaza, Daniel, additional, Aylward, Philip, additional, Johanson, Per, additional, and Bonaca, Marc P., additional

Published
2020
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43. COMPARISON BETWEEN TWO DIFFERENT LOCAL HEMOSTASIS TECHNIQUES FOR DENTAL EXTRACTIONS IN PATIENTS ON DUAL ANTIPLATELET THERAPY: A WITHIN-PERSON, SINGLE-BLIND, RANDOMIZED TRIAL

Author

Guardieiro, Bruno, primary, Santos-Paul, Marcela A., additional, Salsoso, Rocío, additional, Dalçóquio, Talia, additional, Furtado, Remo, additional, Neves, Itamara L.I., additional, Neves, Ricardo S., additional, Filho, Cyrillo Cavalheiro, additional, Baracioli, Luciano, additional, and Nicolau, Jose C., additional

Published
2020
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44. ELECTRICAL STORM AND CARDIOGENIC SHOCK AFTER ACUTE CORONARY SYNDROME REVERTED WITH ECMO CASE REPORT

Author

Ferreira, Mayara Reis Cardoso, primary, Baracioli, Luciano Moreira, additional, Galas, Filomena Regina Barbosa Gomes, additional, Dalcoquio, Talia, additional, Furtado, Remo Holanda, additional, Baldo, Vanessa Maria Gomes Taques, additional, Soffiatti, Carla David, additional, Bertolin, Adriadne Justi, additional, Mustafa, Sumaia, additional, Sobreiro, Daniely Iadocico, additional, and Nicolau, Jose Carlos, additional

Published
2020
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45. IMPACT OF HIGH LIPOPROTEIN(A) LEVELS ON PLATELET AGGREGABILITY IN PATIENTS WITH STABLE CORONARY ARTERY DISEASE

Author

Salsoso, Rocío, primary, Dalçóquio, Talia, additional, Furtado, Remo, additional, Franci, Andre, additional, Barbosa, Carlos, additional, Genestreti, Paulo, additional, Ferreira, Mayara Reis Cardoso, additional, Strunz, Celia, additional, Baracioli, Luciano, additional, Maranhão, Raul Cavalcante, additional, and Nicolau, Jose Carlos, additional

Published
2020
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46. EFFECT OF EXERCISE TRAINING ON PLATELET AGGREGATION AND ON P2Y12 INHIBITOR RESISTANCE AFTER MYOCARDIAL INFARCTION: A RANDOMIZED CLINICAL TRIAL

Author

Dalçóquio, Talia, primary, de Mendonça Furtado, Remo Holanda, additional, Arantes, Flavia Bittar Britto Britto, additional, dos Santos, Mayara Alves, additional, Alves, Leandro Silva, additional, Rondon, Maria Urbana Pinto Brandão, additional, Ferreira-Santos, Larissa, additional, de Nazaré Nunes Alves, Maria Janieire, additional, Ferrari, Aline Gehlen, additional, Genestreti, Paulo Rizzo, additional, Baracioli, Luciano Moreira, additional, Franci, André, additional, Salsoso, Rocio, additional, Negrão, Carlos Eduardo, additional, and Nicolau, José Carlos, additional

Published
2020
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49. Long-term ticagrelor for secondary prevention in patients with prior myocardial infarction and no history of coronary stenting: insights from PEGASUS-TIMI 54

Author

Furtado, Remo H M, primary, Nicolau, Jose C, additional, Magnani, Giulia, additional, Im, Kyungah, additional, Bhatt, Deepak L, additional, Storey, Robert F, additional, Steg, P Gabriel, additional, Spinar, Jindrich, additional, Budaj, Andrzej, additional, Kontny, Frederic, additional, Corbalan, Ramon, additional, Kiss, Robert G, additional, Abola, Maria Teresa, additional, Johanson, Per, additional, Jensen, Eva C, additional, Braunwald, Eugene, additional, Sabatine, Marc S, additional, and Bonaca, Marc P, additional

Published
2019
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50. DAPAGLIFLOZIN AND CARDIOVASCULAR OUTCOMES IN PATIENTS WITH TYPE 2 DIABETES AND PRIOR MYOCARDIAL INFARCTION: A SUB-ANALYSIS FROM DECLARE TIMI-58 TRIAL

Author

de Mendonca Furtado, Remo Holanda, primary, Bonaca, Marc, additional, Raz, Itamar, additional, Zelniker, Thomas, additional, Mosenzon, Ofri, additional, Cahn, Avivit, additional, Kuder, Julia, additional, Murphy, Sabina, additional, Bhatt, Deepak L., additional, Leiter, Lawrence, additional, McGuire, Darren, additional, Wilding, John P.H., additional, Ruff, Christian, additional, Gause-Nilsson, Ingrid A.M., additional, Fredriksson, Martin, additional, Langkilde, Anna Maria, additional, Sabatine, Marc, additional, and Wiviott, Stephen, additional

Published
2019
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