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1. Tracing the origin of SARS-CoV-2 omicron-like spike sequences detected in an urban sewershed: a targeted, longitudinal surveillance study of a cryptic wastewater lineage

Author

Shafer, Martin M, Bobholz, Max J, Vuyk, William C, Gregory, Devon A, Roguet, Adelaide, Haddock Soto, Luis A, Rushford, Clayton, Janssen, Kayley H, Emmen, Isla E, Ries, Hunter J, Pilch, Hannah E, Mullen, Paige A, Fahney, Rebecca B, Wei, Wanting, Lambert, Matthew, Wenzel, Jeff, Halfmann, Peter, Kawaoka, Yoshihiro, Wilson, Nancy A, Friedrich, Thomas C, Pray, Ian W, Westergaard, Ryan, O’Connor, David H, and Johnson, Marc C

Published
2024
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2. Early Embryonic Loss Following Intravaginal Zika Virus Challenge in Rhesus Macaques.

Author

Newman, Christina M, Tarantal, Alice F, Martinez, Michele L, Simmons, Heather A, Morgan, Terry K, Zeng, Xiankun, Rosinski, Jenna R, Bliss, Mason I, Bohm, Ellie K, Dudley, Dawn M, Aliota, Matthew T, Friedrich, Thomas C, Miller, Christopher J, and O'Connor, David H

Subjects
Zika virus, embryonic loss, intravaginal infection, macaques, pregnancy, Immunology, Medical Microbiology
Abstract

Zika virus (ZIKV) is an arthropod-borne virus (arbovirus) and is primarily transmitted by Aedes species mosquitoes; however, ZIKV can also be sexually transmitted. During the initial epidemic and in places where ZIKV is now considered endemic, it is difficult to disentangle the risks and contributions of sexual versus vector-borne transmission to adverse pregnancy outcomes. To examine the potential impact of sexual transmission of ZIKV on pregnancy outcome, we challenged three rhesus macaques (Macaca mulatta) three times intravaginally with 1 x 107 PFU of a low passage, African lineage ZIKV isolate (ZIKV-DAK) in the first trimester (~30 days gestational age). Samples were collected from all animals initially on days 3 through 10 post challenge, followed by twice, and then once weekly sample collection; ultrasound examinations were performed every 3-4 days then weekly as pregnancies progressed. All three dams had ZIKV RNA detectable in plasma on day 3 post-ZIKV challenge. At approximately 45 days gestation (17-18 days post-challenge), two of the three dams were found with nonviable embryos by ultrasound. Viral RNA was detected in recovered tissues and at the maternal-fetal interface (MFI) in both cases. The remaining viable pregnancy proceeded to near term (~155 days gestational age) and ZIKV RNA was detected at the MFI but not in fetal tissues. These results suggest that sexual transmission of ZIKV may represent an underappreciated risk of pregnancy loss during early gestation.

Published
2021

3. SARS-CoV-2 and other respiratory pathogens are detected in continuous air samples from congregate settings

Author

Ramuta, Mitchell D., Newman, Christina M., Brakefield, Savannah F., Stauss, Miranda R., Wiseman, Roger W., Kita-Yarbro, Amanda, O’Connor, Eli J., Dahal, Neeti, Lim, Ailam, Poulsen, Keith P., Safdar, Nasia, Marx, John A., Accola, Molly A., Rehrauer, William M., Zimmer, Julia A., Khubbar, Manjeet, Beversdorf, Lucas J., Boehm, Emma C., Castañeda, David, Rushford, Clayton, Gregory, Devon A., Yao, Joseph D., Bhattacharyya, Sanjib, Johnson, Marc C., Aliota, Matthew T., Friedrich, Thomas C., O’Connor, David H., and O’Connor, Shelby L.

Published
2022
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5. Interventions to Disrupt Coronavirus Disease Transmission at a University, Wisconsin, USA, August-October 2020

Author

Currie, Dustin W., Moreno, Gage K., Delahoy, Miranda J., Pray, Ian W., Jovaag, Amanda, Braun, Katarina M., Cole, Devlin, Shechter, Todd, Fajardo, Geroncio C., Griggs, Carol, Yandell, Brian S., Goldstein, Steve, Bushman, Dena, Segaloff, Hannah E., Kelly, G. Patrick, Pitts, Collin, Lee, Christine, Grande, Katarina M., Kita-Yarbro, Amanda, Grogan, Brittany, Mader, Sara, Baggott, Jake, Bateman, Allen C., Westergaard, Ryan P., Tate, Jacqueline E., Friedrich, Thomas C., Kirking, Hannah L., O'Connor, David H., and Killerby, Marie E.

Subjects
Wisconsin -- Health aspects, Epidemics -- Control -- Statistics -- United States, Public universities and colleges -- Safety and security measures -- Health aspects, Disease transmission -- Control, Health, University of Wisconsin -- Safety and security measures -- Health aspects
Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes coronavirus disease (COVID-19), can spread rapidly within congregate settings, including institutions of higher education (IHEs) (1,2). During August-December 2020, as IHEs [...]

Published
2021
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6. Miscarriage and stillbirth following maternal Zika virus infection in nonhuman primates.

Author

Dudley, Dawn M, Van Rompay, Koen K, Coffey, Lark L, Ardeshir, Amir, Keesler, Rebekah I, Bliss-Moreau, Eliza, Grigsby, Peta L, Steinbach, Rosemary J, Hirsch, Alec J, MacAllister, Rhonda P, Pecoraro, Heidi L, Colgin, Lois M, Hodge, Travis, Streblow, Daniel N, Tardif, Suzette, Patterson, Jean L, Tamhankar, Manasi, Seferovic, Maxim, Aagaard, Kjersti M, Martín, Claudia Sánchez-San, Chiu, Charles Y, Panganiban, Antonito T, Veazey, Ronald S, Wang, Xiaolei, Maness, Nicholas J, Gilbert, Margaret H, Bohm, Rudolf P, Adams Waldorf, Kristina M, Gale, Michael, Rajagopal, Lakshmi, Hotchkiss, Charlotte E, Mohr, Emma L, Capuano, Saverio V, Simmons, Heather A, Mejia, Andres, Friedrich, Thomas C, Golos, Thaddeus G, and O'Connor, David H

Subjects
Animals, Primates, Abortion, Spontaneous, Pregnancy, Female, Male, Stillbirth, Kaplan-Meier Estimate, Zika Virus, Zika Virus Infection, Abortion, Spontaneous, Immunology, Medical and Health Sciences
Abstract

Zika virus (ZIKV) infection is associated with congenital defects and pregnancy loss. Here, we found that 26% of nonhuman primates infected with Asian/American ZIKV in early gestation experienced fetal demise later in pregnancy despite showing few clinical signs of infection. Pregnancy loss due to asymptomatic ZIKV infection may therefore be a common but under-recognized adverse outcome related to maternal ZIKV infection.

Published
2018

7. Prior dengue virus serotype 3 infection modulates subsequent plasmablast responses to Zika virus infection in rhesus macaques

Author

Singh, Tulika, primary, Miller, Itzayana G., additional, Venkatayogi, Sravani, additional, Webster, Helen, additional, Heimsath, Holly J., additional, Eudailey, Josh A., additional, Dudley, Dawn M., additional, Kumar, Amit, additional, Mangan, Riley J., additional, Thein, Amelia, additional, Aliota, Matthew T., additional, Newman, Christina M., additional, Mohns, Mariel S., additional, Breitbach, Meghan E., additional, Berry, Madison, additional, Friedrich, Thomas C., additional, Wiehe, Kevin, additional, O'Connor, David H., additional, and Permar, Sallie R., additional

Published
2024
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8. Potent antibody-dependent cellular cytotoxicity of a V2-specific antibody is not sufficient for protection of macaques against SIV challenge

Author

Grunst, Michael W., primary, Gil, Hwi Min, additional, Grandea, Andres G., additional, Snow, Brian J., additional, Andrabi, Raiees, additional, Nedellec, Rebecca, additional, Burton, Iszac, additional, Clark, Natasha M., additional, Janaka, Sanath Kumar, additional, Keles, Nida K., additional, Moriarty, Ryan V., additional, Weiler, Andrea M., additional, Capuano, Saverio, additional, Fennessey, Christine M., additional, Friedrich, Thomas C., additional, O’Connor, Shelby L., additional, O’Connor, David H., additional, Broman, Aimee T., additional, Keele, Brandon F., additional, Lifson, Jeffrey D., additional, Hangartner, Lars, additional, Burton, Dennis R., additional, and Evans, David T., additional

Published
2024
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9. Highly efficient maternal-fetal Zika virus transmission in pregnant rhesus macaques.

Author

Nguyen, Sydney M, Antony, Kathleen M, Dudley, Dawn M, Kohn, Sarah, Simmons, Heather A, Wolfe, Bryce, Salamat, M Shahriar, Teixeira, Leandro BC, Wiepz, Gregory J, Thoong, Troy H, Aliota, Matthew T, Weiler, Andrea M, Barry, Gabrielle L, Weisgrau, Kim L, Vosler, Logan J, Mohns, Mariel S, Breitbach, Meghan E, Stewart, Laurel M, Rasheed, Mustafa N, Newman, Christina M, Graham, Michael E, Wieben, Oliver E, Turski, Patrick A, Johnson, Kevin M, Post, Jennifer, Hayes, Jennifer M, Schultz-Darken, Nancy, Schotzko, Michele L, Eudailey, Josh A, Permar, Sallie R, Rakasz, Eva G, Mohr, Emma L, Capuano, Saverio, Tarantal, Alice F, Osorio, Jorge E, O'Connor, Shelby L, Friedrich, Thomas C, O'Connor, David H, and Golos, Thaddeus G

Subjects
Lung, Decidua, Spleen, Amniotic Fluid, Umbilical Cord, Fetus, Placenta, Animals, Macaca mulatta, Humans, Pregnancy Complications, Infectious, Viremia, Disease Models, Animal, RNA, Viral, Fetal Development, Pregnancy, Female, Infectious Disease Transmission, Vertical, Zika Virus, Zika Virus Infection, Disease Models, Animal, Infectious Disease Transmission, Vertical, Pregnancy Complications, Infectious, RNA, Viral, Virology, Microbiology, Immunology, Medical Microbiology
Abstract

Infection with Zika virus (ZIKV) is associated with human congenital fetal anomalies. To model fetal outcomes in nonhuman primates, we administered Asian-lineage ZIKV subcutaneously to four pregnant rhesus macaques. While non-pregnant animals in a previous study contemporary with the current report clear viremia within 10-12 days, maternal viremia was prolonged in 3 of 4 pregnancies. Fetal head growth velocity in the last month of gestation determined by ultrasound assessment of head circumference was decreased in comparison with biparietal diameter and femur length within each fetus, both within normal range. ZIKV RNA was detected in tissues from all four fetuses at term cesarean section. In all pregnancies, neutrophilic infiltration was present at the maternal-fetal interface (decidua, placenta, fetal membranes), in various fetal tissues, and in fetal retina, choroid, and optic nerve (first trimester infection only). Consistent vertical transmission in this primate model may provide a platform to assess risk factors and test therapeutic interventions for interruption of fetal infection. The results may also suggest that maternal-fetal ZIKV transmission in human pregnancy may be more frequent than currently appreciated.

Published
2017

10. Seroprevalence of Zika Virus in Wild African Green Monkeys and Baboons

Author

Buechler, Connor R, Bailey, Adam L, Weiler, Andrea M, Barry, Gabrielle L, Breitbach, Meghan E, Stewart, Laurel M, Jasinska, Anna J, Freimer, Nelson B, Apetrei, Cristian, Phillips-Conroy, Jane E, Jolly, Clifford J, Rogers, Jeffrey, Friedrich, Thomas C, and O’Connor, David H

Subjects
Microbiology, Biological Sciences, Infectious Diseases, Vector-Borne Diseases, Contraception/Reproduction, Emerging Infectious Diseases, Pediatric, Vaccine Related, Aetiology, 2.2 Factors relating to the physical environment, Infection, Good Health and Well Being, false-positive reactions, Flavivirus, sensitivity and specificity, seroepidemiologic studies, Zika virus, Zika virus infection
Abstract

Zika virus (ZIKV) has recently spread through the Americas and has been associated with a range of health effects, including birth defects in children born to women infected during pregnancy. Although the natural reservoir of ZIKV remains poorly defined, the virus was first identified in a captive "sentinel" macaque monkey in Africa in 1947. However, the virus has not been reported in humans or nonhuman primates (NHPs) in Africa outside Gabon in over a decade. Here, we examine ZIKV infection in 239 wild baboons and African green monkeys from South Africa, the Gambia, Tanzania, and Zambia using combinations of unbiased deep sequencing, quantitative reverse transcription-PCR (qRT-PCR), and an antibody capture assay that we optimized using serum collected from captive macaque monkeys exposed to ZIKV, dengue virus, and yellow fever virus. While we did not find evidence of active ZIKV infection in wild NHPs in Africa, we found variable ZIKV seropositivity of up to 16% in some of the NHP populations sampled. We anticipate that these results and the methodology described within will help in continued efforts to determine the prevalence, natural reservoir, and transmission dynamics of ZIKV in Africa and elsewhere. IMPORTANCE Zika virus (ZIKV) is a mosquito-borne virus originally discovered in a captive monkey living in the Zika Forest of Uganda, Africa, in 1947. Recently, an outbreak in South America has shown that ZIKV infection can cause myriad health effects, including birth defects in the children of women infected during pregnancy. Here, we sought to investigate ZIKV infection in wild African primates to better understand its emergence and spread, looking for evidence of active or prior infection. Our results suggest that up to 16% of some populations of nonhuman primate were, at some point, exposed to ZIKV. We anticipate that this study will be useful for future studies that examine the spread of infections from wild animals to humans in general and those studying ZIKV in primates in particular.

Published
2017

11. Viral factors in influenza pandemic risk assessment.

Author

Lipsitch, Marc, Barclay, Wendy, Raman, Rahul, Russell, Charles J, Belser, Jessica A, Cobey, Sarah, Kasson, Peter M, Lloyd-Smith, James O, Maurer-Stroh, Sebastian, Riley, Steven, Beauchemin, Catherine Aa, Bedford, Trevor, Friedrich, Thomas C, Handel, Andreas, Herfst, Sander, Murcia, Pablo R, Roche, Benjamin, Wilke, Claus O, and Russell, Colin A

Subjects
Animals, Humans, Influenza A virus, Zoonoses, RNA Replicase, Hemagglutinin Glycoproteins, Influenza Virus, Virulence Factors, Risk Assessment, Influenza, Human, Pandemics, Epidemiological Monitoring, epidemiology, global health, human, infectious disease, influenza A, microbiology, pandemic, risk prediction, virus, Hemagglutinin Glycoproteins, Influenza Virus, Influenza, Human, Biochemistry and Cell Biology
Abstract

The threat of an influenza A virus pandemic stems from continual virus spillovers from reservoir species, a tiny fraction of which spark sustained transmission in humans. To date, no pandemic emergence of a new influenza strain has been preceded by detection of a closely related precursor in an animal or human. Nonetheless, influenza surveillance efforts are expanding, prompting a need for tools to assess the pandemic risk posed by a detected virus. The goal would be to use genetic sequence and/or biological assays of viral traits to identify those non-human influenza viruses with the greatest risk of evolving into pandemic threats, and/or to understand drivers of such evolution, to prioritize pandemic prevention or response measures. We describe such efforts, identify progress and ongoing challenges, and discuss three specific traits of influenza viruses (hemagglutinin receptor binding specificity, hemagglutinin pH of activation, and polymerase complex efficiency) that contribute to pandemic risk.

Published
2016

12. Zoonotic Potential of Simian Arteriviruses

Author

Bailey, Adam L, Lauck, Michael, Sibley, Samuel D, Friedrich, Thomas C, Kuhn, Jens H, Freimer, Nelson B, Jasinska, Anna J, Phillips-Conroy, Jane E, Jolly, Clifford J, Marx, Preston A, Apetrei, Cristian, Rogers, Jeffrey, Goldberg, Tony L, and O'Connor, David H

Subjects
Emerging Infectious Diseases, Vaccine Related, Prevention, Infectious Diseases, Vector-Borne Diseases, Genetics, 2.2 Factors relating to the physical environment, Aetiology, Infection, Animals, Arterivirus, Arterivirus Infections, Haplorhini, Humans, Primate Diseases, Zoonoses, Biological Sciences, Agricultural and Veterinary Sciences, Medical and Health Sciences, Virology
Abstract

Wild nonhuman primates are immediate sources and long-term reservoirs of human pathogens. However, ethical and technical challenges have hampered the identification of novel blood-borne pathogens in these animals. We recently examined RNA viruses in plasma from wild African monkeys and discovered several novel, highly divergent viruses belonging to the family Arteriviridae. Close relatives of these viruses, including simian hemorrhagic fever virus, have caused sporadic outbreaks of viral hemorrhagic fever in captive macaque monkeys since the 1960s. However, arterivirus infection in wild nonhuman primates had not been described prior to 2011. The arteriviruses recently identified in wild monkeys have high sequence and host species diversity, maintain high viremia, and are prevalent in affected populations. Taken together, these features suggest that the simian arteriviruses may be "preemergent" zoonotic pathogens. If not, this would imply that biological characteristics of RNA viruses thought to facilitate zoonotic transmission may not, by themselves, be sufficient for such transmission to occur.

Published
2016

13. Gain without pain: adaptation and increased virulence of Zika virus in vertebrate host without fitness cost in mosquito vector

Author

Jaeger, Anna S., primary, Marano, Jeffrey, additional, Riemersma, Kasen K., additional, Castaneda, David, additional, Pritchard, Elise M., additional, Pritchard, Julia C., additional, Bohm, Ellie K., additional, Baczenas, John J., additional, O'Connor, Shelby L., additional, Weger-Lucarelli, James, additional, Friedrich, Thomas C., additional, and Aliota, Matthew T., additional

Published
2023
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14. Wolbachia-mediated resistance to Zika virus infection in Aedes aegypti is dominated by diverse transcriptional regulation and weak evolutionary pressures

Author

Boehm, Emma C., primary, Jaeger, Anna S., additional, Ries, Hunter J., additional, Castañeda, David, additional, Weiler, Andrea M., additional, Valencia, Corina C., additional, Weger-Lucarelli, James, additional, Ebel, Gregory D., additional, O’Connor, Shelby L., additional, Friedrich, Thomas C., additional, Zamanian, Mostafa, additional, and Aliota, Matthew T., additional

Published
2023
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16. CD8+ cells and small viral reservoirs facilitate post-ART control of SIV replication in M3+ Mauritian cynomolgus macaques initiated on ART two weeks post-infection

Author

Harwood, Olivia E., primary, Matschke, Lea M., additional, Moriarty, Ryan V., additional, Balgeman, Alexis J., additional, Weaver, Abigail J., additional, Ellis-Connell, Amy L., additional, Weiler, Andrea M., additional, Winchester, Lee C., additional, Fletcher, Courtney V., additional, Friedrich, Thomas C., additional, Keele, Brandon F., additional, O’Connor, David H., additional, Lang, Jessica D., additional, Reynolds, Matthew R., additional, and O’Connor, Shelby L., additional

Published
2023
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17. Control of maternal Zika virus infection during pregnancy is associated with lower antibody titers in a macaque model

Author

Krabbe, Nicholas P., primary, Razo, Elaina, additional, Abraham, Hunter J., additional, Spanton, Rachel V., additional, Shi, Yujia, additional, Bhattacharya, Saswati, additional, Bohm, Ellie K., additional, Pritchard, Julia C., additional, Weiler, Andrea M., additional, Mitzey, Ann M., additional, Eickhoff, Jens C., additional, Sullivan, Eric, additional, Tan, John C., additional, Aliota, Matthew T., additional, Friedrich, Thomas C., additional, O’Connor, David H., additional, Golos, Thaddeus G., additional, and Mohr, Emma L., additional

Published
2023
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18. Vertical transmission of African-lineage Zika virus through the fetal membranes in a rhesus macaque (Macaca mulatta) model

Author

Koenig, Michelle R., primary, Mitzey, Ann M., additional, Zeng, Xiankun, additional, Reyes, Leticia, additional, Simmons, Heather A., additional, Morgan, Terry K., additional, Bohm, Ellie K., additional, Pritchard, Julia C., additional, Schmidt, Jenna A., additional, Ren, Emily, additional, Leyva Jaimes, Fernanda B., additional, Winston, Eva, additional, Basu, Puja, additional, Weiler, Andrea M., additional, Friedrich, Thomas C., additional, Aliota, Matthew T., additional, Mohr, Emma L., additional, and Golos, Thaddeus G., additional

Published
2023
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19. Using Virus Sequencing to Determine Source of SARS-CoV-2 Transmission for Healthcare Worker

Author

Safdar, Nasia, Moreno, Gage K., Braun, Katarina M., Friedrich, Thomas C., and O'Connor, David H.

Subjects
Severe acute respiratory syndrome -- Health aspects, Coronaviruses -- Health aspects, Cross infection -- Health aspects, Disease susceptibility -- Health aspects, Medical personnel -- Health aspects, Infection control -- Health aspects, COVID-19 -- Health aspects, Health
Abstract

Healthcare workers (HCWs) are at the front lines of the coronavirus disease (COVID-19) pandemic; their interactions with patients and in the community put them at risk for infection with severe [...]

Published
2020
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20. Revealing fine-scale spatiotemporal differences in SARS-CoV-2 introduction and spread

Author

Moreno, Gage K., Braun, Katarina M., Riemersma, Kasen K., Martin, Michael A., Halfmann, Peter J., Crooks, Chelsea M., Prall, Trent, Baker, David, Baczenas, John J., Heffron, Anna S., Ramuta, Mitchell, Khubbar, Manjeet, Weiler, Andrea M., Accola, Molly A., Rehrauer, William M., O’Connor, Shelby L., Safdar, Nasia, Pepperell, Caitlin S., Dasu, Trivikram, Bhattacharyya, Sanjib, Kawaoka, Yoshihiro, Koelle, Katia, O’Connor, David H., and Friedrich, Thomas C.

Published
2020
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21. Primary infection with Zika virus provides one-way heterologous protection against Spondweni virus infection in rhesus macaques

Author

Jaeger, Anna S., primary, Crooks, Chelsea M., additional, Weiler, Andrea M., additional, Bliss, Mason I., additional, Rybarczyk, Sierra, additional, Richardson, Alex, additional, Einwalter, Morgan, additional, Peterson, Eric, additional, Capuano, Saverio, additional, Barkhymer, Alison, additional, Becker, Jordan T., additional, Greene, Joseph T., additional, Freedman, Tanya S., additional, Langlois, Ryan A., additional, Friedrich, Thomas C., additional, and Aliota, Matthew T., additional

Published
2023
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22. Infection of the maternal-fetal interface and vertical transmission following low-dose inoculation of pregnant rhesus macaques (Macaca mulatta) with an African-lineage Zika virus

Author

Koenig, Michelle R., primary, Mitzey, Ann M., additional, Morgan, Terry K., additional, Zeng, Xiankun, additional, Simmons, Heather A., additional, Mejia, Andres, additional, Leyva Jaimes, Fernanda, additional, Keding, Logan T., additional, Crooks, Chelsea M., additional, Weiler, Andrea M., additional, Bohm, Ellie K., additional, Aliota, Matthew T., additional, Friedrich, Thomas C., additional, Mohr, Emma L., additional, and Golos, Thaddeus G., additional

Published
2023
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23. Frequent first-trimester pregnancy loss in rhesus macaques infected with African-lineage Zika virus

Author

Rosinski, Jenna R., primary, Raasch, Lauren E., additional, Barros Tiburcio, Patrick, additional, Breitbach, Meghan E., additional, Shepherd, Phoenix M., additional, Yamamoto, Keisuke, additional, Razo, Elaina, additional, Krabbe, Nicholas P., additional, Bliss, Mason I., additional, Richardson, Alexander D., additional, Einwalter, Morgan A., additional, Weiler, Andrea M., additional, Sneed, Emily L., additional, Fuchs, Kerri B., additional, Zeng, Xiankun, additional, Noguchi, Kevin K., additional, Morgan, Terry K., additional, Alberts, Alexandra J., additional, Antony, Kathleen M., additional, Kabakov, Sabrina, additional, Ausderau, Karla K., additional, Bohm, Ellie K., additional, Pritchard, Julia C., additional, Spanton, Rachel V., additional, Ver Hoove, James N., additional, Kim, Charlene B. Y., additional, Nork, T. Michael, additional, Katz, Alex W., additional, Rasmussen, Carol A., additional, Hartman, Amy, additional, Mejia, Andres, additional, Basu, Puja, additional, Simmons, Heather A., additional, Eickhoff, Jens C., additional, Friedrich, Thomas C., additional, Aliota, Matthew T., additional, Mohr, Emma L., additional, Dudley, Dawn M., additional, O’Connor, David H., additional, and Newman, Christina M., additional

Published
2023
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24. Avian H7N9 influenza viruses are evolutionarily constrained by stochastic processes during replication and transmission in mammals

Author

Braun, Katarina M, primary, Haddock III, Luis A, additional, Crooks, Chelsea M, additional, Barry, Gabrielle L, additional, Lalli, Joseph, additional, Neumann, Gabriele, additional, Watanabe, Tokiko, additional, Imai, Masaki, additional, Yamayoshi, Seiya, additional, Ito, Mutsumi, additional, Moncla, Louise H, additional, Koelle, Katia, additional, Kawaoka, Yoshihiro, additional, and Friedrich, Thomas C, additional

Published
2023
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25. Evolution of a globally unique SARS-CoV-2 Spike E484T monoclonal antibody escape mutation in a persistently infected, immunocompromised individual.

Author

Halfmann, Peter J, Minor, Nicholas R, III, Luis A Haddock, Maddox, Robert, Moreno, Gage K, Braun, Katarina M, Baker, David A, Riemersa, Kasen K, Prasad, Ankur, Alman, Kirsten J, Lambert, Matthew C, Florek, Kelsey, Bateman, Allen, Westergaard, Ryan, Safdar, Nasia, Andes, David R, Kawaoka, Yoshihiro, Fida, Madiha, Yao, Joseph D, and Friedrich, Thomas C

Subjects
SARS-CoV-2, IMMUNOCOMPROMISED patients, MONOCLONAL antibodies, SARS-CoV-2 Omicron variant
Abstract

Prolonged infections in immunocompromised individuals may be a source for novel Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) variants, particularly when both the immune system and antiviral therapy fail to clear the infection and enable within-host evolution. Here we describe a 486-day case of SARS-CoV-2 infection in an immunocompromised individual. Following monotherapy with the monoclonal antibody Bamlanivimab, the individual's virus acquired resistance, likely via the earliest known occurrence of Spike amino acid variant E484T. Recently, E484T has arisen again as a derivative of E484A in the Omicron Variant of Concern, supporting the hypothesis that prolonged infections can give rise to novel variants long before they become prevalent in the human population. [ABSTRACT FROM AUTHOR]

Published
2023
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26. Transient T Cell Expansion, Activation, and Proliferation in Therapeutically Vaccinated Simian Immunodeficiency Virus-Positive Macaques Treated with N-803

Author

Harwood, Olivia E., primary, Balgeman, Alexis J., additional, Weaver, Abigail J., additional, Ellis-Connell, Amy L., additional, Weiler, Andrea M., additional, Erickson, Katrina N., additional, Matschke, Lea M., additional, Golfinos, Athena E., additional, Vezys, Vaiva, additional, Skinner, Pamela J., additional, Safrit, Jeffrey T., additional, Edlefsen, Paul T., additional, Reynolds, Matthew R., additional, Friedrich, Thomas C., additional, and O’Connor, Shelby L., additional

Published
2022
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27. Toward the determination of sensitive and reliable whole-lung computed tomography features for robust standard radiomics and delta-radiomics analysis in a nonhuman primate model of coronavirus disease 2019

Author

Castro, Marcelo A., primary, Reza, Syed, additional, Chu, Winston T., additional, Bradley, Dara, additional, Lee, Ji Hyun, additional, Crozier, Ian, additional, Sayre, Philip J., additional, Lee, Byeong Y., additional, Mani, Venkatesh, additional, Friedrich, Thomas C., additional, O’Connor, David H., additional, Finch, Courtney L., additional, Worwa, Gabriella, additional, Feuerstein, Irwin M., additional, Kuhn, Jens H., additional, and Solomon, Jeffrey, additional

Published
2022
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28. Evolution of a globally unique SARS-CoV-2 Spike E484T monoclonal antibody escape mutation in a persistently infected, immunocompromised individual

Author

Halfmann, Peter J, primary, Minor, Nicholas R, additional, Haddock III, Luis A, additional, Maddox, Robert, additional, Moreno, Gage K, additional, Braun, Katarina M, additional, Baker, David A, additional, Riemersa, Kasen K, additional, Prasad, Ankur, additional, Alman, Kirsten J, additional, Lambert, Matthew C, additional, Florek, Kelsey, additional, Bateman, Allen, additional, Westergaard, Ryan, additional, Safdar, Nasia, additional, Andes, David R, additional, Kawaoka, Yoshihiro, additional, Fida, Madiha, additional, Yao, Joseph D, additional, Friedrich, Thomas C, additional, and O’Connor, David H, additional

Published
2022
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29. Control of Simian Immunodeficiency Virus Infection in Prophylactically Vaccinated, Antiretroviral Treatment-Naive Macaques Is Required for the Most Efficacious CD8 T Cell Response during Treatment with the Interleukin-15 Superagonist N-803

Author

Ellis-Connell, Amy L., primary, Balgeman, Alexis J., additional, Harwood, Olivia E., additional, Moriarty, Ryan V., additional, Safrit, Jeffrey T., additional, Weiler, Andrea M., additional, Friedrich, Thomas C., additional, and O’Connor, Shelby L., additional

Published
2022
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30. Shedding of infectious SARS-CoV-2 despite vaccination

Author

Riemersma, Kasen K., primary, Haddock, Luis A., additional, Wilson, Nancy A., additional, Minor, Nicholas, additional, Eickhoff, Jens, additional, Grogan, Brittany E., additional, Kita-Yarbro, Amanda, additional, Halfmann, Peter J., additional, Segaloff, Hannah E., additional, Kocharian, Anna, additional, Florek, Kelsey R., additional, Westergaard, Ryan, additional, Bateman, Allen, additional, Jeppson, Gunnar E., additional, Kawaoka, Yoshihiro, additional, O’Connor, David H., additional, Friedrich, Thomas C., additional, and Grande, Katarina M., additional

Published
2022
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31. Fetal loss in pregnant rhesus macaques infected with high-dose African-lineage Zika virus

Author

Raasch, Lauren E., primary, Yamamoto, Keisuke, additional, Newman, Christina M., additional, Rosinski, Jenna R., additional, Shepherd, Phoenix M., additional, Razo, Elaina, additional, Crooks, Chelsea M., additional, Bliss, Mason I., additional, Breitbach, Meghan E., additional, Sneed, Emily L., additional, Weiler, Andrea M., additional, Zeng, Xiankun, additional, Noguchi, Kevin K., additional, Morgan, Terry K., additional, Fuhler, Nicole A., additional, Bohm, Ellie K., additional, Alberts, Alexandra J., additional, Havlicek, Samantha J., additional, Kabakov, Sabrina, additional, Mitzey, Ann M., additional, Antony, Kathleen M., additional, Ausderau, Karla K., additional, Mejia, Andres, additional, Basu, Puja, additional, Simmons, Heather A., additional, Eickhoff, Jens C., additional, Aliota, Matthew T., additional, Mohr, Emma L., additional, Friedrich, Thomas C., additional, Golos, Thaddeus G., additional, O’Connor, David H., additional, and Dudley, Dawn M., additional

Published
2022
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32. Human immune globulin treatment controls Zika viremia in pregnant rhesus macaques

Author

Dudley, Dawn M., primary, Koenig, Michelle R., additional, Stewart, Laurel M., additional, Semler, Matthew R., additional, Newman, Christina M., additional, Shepherd, Phoenix M., additional, Yamamoto, Keisuke, additional, Breitbach, Meghan E., additional, Schotzko, Michele, additional, Kohn, Sarah, additional, Antony, Kathleen M., additional, Qiu, Hongyu, additional, Tunga, Priyadarshini, additional, Anderson, Deborah M., additional, Guo, Wendi, additional, Dennis, Maria, additional, Singh, Tulika, additional, Rybarczyk, Sierra, additional, Weiler, Andrea M., additional, Razo, Elaina, additional, Mitzey, Ann, additional, Zeng, Xiankun, additional, Eickhoff, Jens C., additional, Mohr, Emma L., additional, Simmons, Heather A., additional, Fritsch, Michael K., additional, Mejia, Andres, additional, Aliota, Matthew T., additional, Friedrich, Thomas C., additional, Golos, Thaddeus G., additional, Kodihalli, Shantha, additional, Permar, Sallie R., additional, and O’Connor, David H., additional

Published
2022
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34. Oropharyngeal mucosal transmission of Zika virus in rhesus macaques

Author

Newman, Christina M., Dudley, Dawn M., Aliota, Matthew T., Weiler, Andrea M., Barry, Gabrielle L., Mohns, Mariel S., Breitbach, Meghan E., Stewart, Laurel M., Buechler, Connor R., Graham, Michael E., Post, Jennifer, Schultz-Darken, Nancy, Peterson, Eric, Newton, Wendy, Mohr, Emma L., Capuano, III, Saverio, O’Connor, David H., and Friedrich, Thomas C.

Published
2017
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35. Evidence of Early Household Transmission of SARS-CoV-2 Involving a School-Aged Child

Author

Temte, Jonathan L., Barlow, Shari, Temte, Emily, Goss, Maureen, Florek, Kelsey, Braun, Katrina, Friedrich, Thomas C., Reisdorf, Erik, Bateman, Allen C., and Uzicanin, Amra

Subjects
Article
Abstract

INTRODUCTION: Little is known about the role of school-aged children and household transmission at the start of the SARS-CoV-2 pandemic. To evaluate for SARS-CoV-2 in school-aged children and assess household transmission, we performed reverse transcription polymerase chain reaction on 670 archived specimens that were collected between September 1, 2019 and June 30, 2020 as part of a community-based study. CASE PRESENTATION: A single SARS-CoV-2 case was detected in an 11-year-old girl on March 18, 2020, resulting in very low prevalence (0.15% [95% CI, 0.03–0.84]) in this population. This case was associated with SARS-CoV-2 detection in all other household members. Symptoms were reported as mild to moderate. Whole genome sequencing supported household transmission of near-identical viruses within the 19B clade. DISCUSSION: This case represents the earliest known household cluster of SARS-CoV2 in Wisconsin. CONCLUSION: This case suggests that household transmission associated with school-aged children may have contributed to wide seeding across populations.

Published
2021

38. The mucosal barrier and anti-viral immune responses can eliminate portions of the viral population during transmission and early viral growth

Author

Moriarty, Ryan V., primary, Golfinos, Athena E., additional, Gellerup, Dane D., additional, Schweigert, Hannah, additional, Mathiaparanam, Jaffna, additional, Balgeman, Alexis J., additional, Weiler, Andrea M., additional, Friedrich, Thomas C., additional, Keele, Brandon F., additional, Davenport, Miles P., additional, Venturi, Vanessa, additional, and O’Connor, Shelby L., additional

Published
2021
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39. SARS-CoV-2 Genomic Surveillance Reveals Little Spread From a Large University Campus to the Surrounding Community

Author

Valesano, Andrew L, primary, Fitzsimmons, William J, additional, Blair, Christopher N, additional, Woods, Robert J, additional, Gilbert, Julie, additional, Rudnik, Dawn, additional, Mortenson, Lindsey, additional, Friedrich, Thomas C, additional, O’Connor, David H, additional, MacCannell, Duncan R, additional, Petrie, Joshua G, additional, Martin, Emily T, additional, and Lauring, Adam S, additional

Published
2021
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40. Neonatal Development in Prenatally Zika Virus-Exposed Infant Macaques with Dengue Immunity

Author

Ausderau, Karla, primary, Kabakov, Sabrina, additional, Razo, Elaina, additional, Mitzey, Ann M., additional, Bach, Kathryn M., additional, Crooks, Chelsea M., additional, Dulaney, Natalie, additional, Keding, Logan, additional, Salas-Quinchucua, Cristhian, additional, Medina-Magües, Lex G., additional, Weiler, Andrea M., additional, Bliss, Mason, additional, Eickhoff, Jens, additional, Simmons, Heather A., additional, Mejia, Andres, additional, Antony, Kathleen M., additional, Morgan, Terry, additional, Capuano, Saverio, additional, Schneider, Mary L., additional, Aliota, Matthew T., additional, Friedrich, Thomas C., additional, O’Connor, David H., additional, Golos, Thaddeus G., additional, and Mohr, Emma L., additional

Published
2021
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41. Initial Evaluation of a Mobile SARS-CoV-2 RT-LAMP Testing Strategy

Author

Newman, Christina M., primary, Ramuta, Mitchell D., additional, McLaughlin, Matthew T., additional, Wiseman, Roger W, additional, Karl, Julie A., additional, Dudley, Dawn M., additional, Stauss, Miranda R., additional, Maddox, Robert J., additional, Weiler, Andrea M., additional, Bliss, Mason I., additional, Fauser, Katrina N., additional, Haddock, Luis A., additional, Shortreed, Cecilia G., additional, Haj, Amelia K., additional, Accola, Molly A., additional, Heffron, Anna S., additional, Bussan, Hailey E., additional, Reynolds, Matthew R., additional, Harwood, Olivia E., additional, Moriarty, Ryan V., additional, Stewart, Laurel M., additional, Crooks, Chelsea M., additional, Prall, Trent M., additional, Neumann, Emma K., additional, Somsen, Elizabeth D., additional, Burmeister, Corrie B., additional, Hall, Kristi L., additional, Rehrauer, William M., additional, Friedrich, Thomas C., additional, O'Connor, Shelby L., additional, and O'Connor, David H., additional

Published
2021
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42. Acute SARS-CoV-2 infections harbor limited within-host diversity and transmit via tight transmission bottlenecks

Author

Braun, Katarina M., primary, Moreno, Gage K., additional, Wagner, Cassia, additional, Accola, Molly A., additional, Rehrauer, William M., additional, Baker, David A., additional, Koelle, Katia, additional, O’Connor, David H., additional, Bedford, Trevor, additional, Friedrich, Thomas C., additional, and Moncla, Louise H., additional

Published
2021
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43. Previous exposure to dengue virus is associated with increased Zika virus burden at the maternal-fetal interface in rhesus macaques

Author

Crooks, Chelsea M., primary, Weiler, Andrea M., additional, Rybarczyk, Sierra L., additional, Bliss, Mason I., additional, Jaeger, Anna S., additional, Murphy, Megan E., additional, Simmons, Heather A., additional, Mejia, Andres, additional, Fritsch, Michael K., additional, Hayes, Jennifer M., additional, Eickhoff, Jens C., additional, Mitzey, Ann M., additional, Razo, Elaina, additional, Braun, Katarina M., additional, Brown, Elizabeth A., additional, Yamamoto, Keisuke, additional, Shepherd, Phoenix M., additional, Possell, Amber, additional, Weaver, Kara, additional, Antony, Kathleen M., additional, Morgan, Terry K., additional, Newman, Christina M., additional, Dudley, Dawn M., additional, Schultz-Darken, Nancy, additional, Peterson, Eric, additional, Katzelnick, Leah C., additional, Balmaseda, Angel, additional, Harris, Eva, additional, O’Connor, David H., additional, Mohr, Emma L., additional, Golos, Thaddeus G., additional, Friedrich, Thomas C., additional, and Aliota, Matthew T., additional

Published
2021
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44. African-Lineage Zika Virus Replication Dynamics and Maternal-Fetal Interface Infection in Pregnant Rhesus Macaques

Author

Crooks, Chelsea M., primary, Weiler, Andrea M., additional, Rybarczyk, Sierra L., additional, Bliss, Mason, additional, Jaeger, Anna S., additional, Murphy, Megan E., additional, Simmons, Heather A., additional, Mejia, Andres, additional, Fritsch, Michael K., additional, Hayes, Jennifer M., additional, Eickhoff, Jens C., additional, Mitzey, Ann M., additional, Razo, Elaina, additional, Braun, Katarina M., additional, Brown, Elizabeth A., additional, Yamamoto, Keisuke, additional, Shepherd, Phoenix M., additional, Possell, Amber, additional, Weaver, Kara, additional, Antony, Kathleen M., additional, Morgan, Terry K., additional, Zeng, Xiankun, additional, Dudley, Dawn M., additional, Peterson, Eric, additional, Schultz-Darken, Nancy, additional, O’Connor, David H., additional, Mohr, Emma L., additional, Golos, Thaddeus G., additional, Aliota, Matthew T., additional, and Friedrich, Thomas C., additional

Published
2021
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45. Naturally circulating hepatitis a virus in Olive Baboons, Uganda

Author

Bennett, Andrew J., Sibley, Samuel D., Lauck, Michael, Weny, Geoffrey, Hyeroba, David, Tumukunde, Alex, Friedrich, Thomas C., O'Connor, David H., Johnson, Caley A., Rothman, Jessica M., and Goldberg, Tony L.

Subjects
Hepatitis A -- Distribution, Baboons -- Health aspects, Zoonoses -- Distribution, Company distribution practices, Health
Abstract

To the Editor: Hepatitis A (HAV; family Picornaviridae; genus Hepatovirus) is an ≅ 7.5-kb single-stranded positive-sense RNA virus that causes acute inflammation of the liver in humans and nonhuman primates. [...]

Published
2016

46. #20: Modeling Zika virus tissue tropism in rhesus macaques to define the risk of donor derived transmission

Author

Treadway, Taylor A, primary, Shepherd, Phoenix M, additional, Newman, Christina M, additional, Mohr, Emma L, additional, Dudley, Dawn M, additional, Breitbach, Meghan E, additional, Yamamoto, Keisuke, additional, Stewart, Laurel M, additional, Koenig, Michelle R, additional, Bliss, Mason, additional, Rybarczyk, Sierra L, additional, Weiler, Andrea M, additional, Semler, Matthew R, additional, Mitzey, Ann, additional, Razo, Elaina, additional, Schotzko, Michele, additional, Peterson, Eric, additional, Simmons, Heather A, additional, Mejia, Andres, additional, Golos, Thaddeus G, additional, Friedrich, Thomas C, additional, and O’Connor, David H, additional

Published
2021
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47. Early Embryonic Loss Following Intravaginal Zika Virus Challenge in Rhesus Macaques

Author

Newman, Christina M., primary, Tarantal, Alice F., additional, Martinez, Michele L., additional, Simmons, Heather A., additional, Morgan, Terry K., additional, Zeng, Xiankun, additional, Rosinski, Jenna R., additional, Bliss, Mason I., additional, Bohm, Ellie K., additional, Dudley, Dawn M., additional, Aliota, Matthew T., additional, Friedrich, Thomas C., additional, Miller, Christopher J., additional, and O’Connor, David H., additional

Published
2021
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48. Development and Characterization of a cDNA-Launch Recombinant Simian Hemorrhagic Fever Virus Expressing Enhanced Green Fluorescent Protein: ORF 2b’ Is Not Required for In Vitro Virus Replication

Author

Cai, Yingyun, primary, Yu, Shuiqing, additional, Fang, Ying, additional, Bollinger, Laura, additional, Li, Yanhua, additional, Lauck, Michael, additional, Postnikova, Elena N., additional, Mazur, Steven, additional, Johnson, Reed F., additional, Finch, Courtney L., additional, Radoshitzky, Sheli R., additional, Palacios, Gustavo, additional, Friedrich, Thomas C., additional, Goldberg, Tony L., additional, O’Connor, David H., additional, Jahrling, Peter B., additional, and Kuhn, Jens H., additional

Published
2021
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50. #79: Modeling Zika Virus Tissue Tropism in Rhesus Macaques to Define the Risk of Donor-derived Transmission

Author

Treadway, Taylor A, primary, Shepherd, Phoenix M, additional, Newman, Christina M, additional, Mohr, Emma L, additional, Dudley, Dawn M, additional, Breitbach, Meghan E, additional, Yamamoto, Keisuke, additional, Stewart, Laurel M, additional, Koenig, Michelle R, additional, Bliss, Mason, additional, Rybarczyk, Sierra L, additional, Weiler, Andrea M, additional, Semler, Matthew R, additional, Mitzey, Ann, additional, Razo, Elaina, additional, Schotzko, Michele, additional, Peterson, Eric, additional, Simmons, Heather A, additional, Mejia, Andres, additional, Golos, Thaddeus G, additional, Friedrich, Thomas C, additional, and O’Connor, David H, additional

Published
2021
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