Search

Your search keyword '"Frese, G."' showing total 3 results
Start Over Author "Frese, G." Search Limiters Full Text
3 results on '"Frese, G."'

3. Susceptibility of multidrug-resistant human leukemia cell lines to human interleukin 2-activated killer cells.

Author

Kimmig A, Gekeler V, Neumann M, Frese G, Handgretinger R, Kardos G, Diddens H, and Niethammer D

Subjects
ATP Binding Cassette Transporter, Subfamily B, Member 1, Antigens, CD7, Antigens, Differentiation immunology, Antigens, Differentiation, T-Lymphocyte immunology, Drug Resistance, Gene Expression Regulation, Neoplastic, Histocompatibility Antigens immunology, Humans, Leukemia genetics, Leukemia immunology, Leukocyte Common Antigens, Lewis X Antigen, Membrane Glycoproteins genetics, Phenotype, Tumor Cells, Cultured, Verapamil pharmacology, Immunotherapy, Adoptive, Interleukin-2 pharmacology, Killer Cells, Lymphokine-Activated physiology, Leukemia therapy
Abstract

Considering the possibility to overcome drug resistance by other treatment strategies than chemotherapy we investigated the susceptibility of three independently selected multidrug-resistant sublines of the T-lymphoblastoid leukemic cell line CCRF-CEM to lymphokine-activated killer (LAK) cells. We found that two of the multidrug-resistant sublines were significantly less susceptible targets to LAK cells. A third one, however, was as susceptible as the parental CCRF-CEM cell line. Moreover, a multidrug-resistant subline that reverted to an almost drug-sensitive phenotype was observed to be also revertant for resistance against LAK cells. We found an inverse relationship between the expression of the mdr1 gene (P-glycoprotein) and the susceptibility to LAK cells. Verapamil, a calcium channel blocker, while increasing the drug sensitivity of a multidrug-resistant subline, did not induce a reversal of the suppression of LAK susceptibility. The possibility of enhanced resistance to LAK cells of multidrug-resistant cells should be taken into account when one is looking for therapy strategies to overcome multidrug resistance.

Published
1990

Catalog

Books, media, physical & digital resources
See catalog results