52 results on '"Franco Regli"'
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2. Prix Franco Regli 20202021
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Franco-Regli-Stiftung Fondation Franco Regli
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Microbiology (medical) ,Immunology ,Immunology and Allergy - Published
- 2021
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3. An additional family with Startle disease and a G1192A mutation at the α1 subunit of the inhibitory glycine receptor gene
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Daniel F. Schorderet, Graziano Pescia, Andrea Bernasconi, and Franco Regli
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Male ,Myoclonus ,Reflex, Startle ,congenital, hereditary, and neonatal diseases and abnormalities ,Adolescent ,Protein subunit ,Interleukin 5 receptor alpha subunit ,Alpha (ethology) ,Biology ,medicine.disease_cause ,Polymerase Chain Reaction ,Gamma-aminobutyric acid receptor subunit alpha-1 ,Interleukin 10 receptor, alpha subunit ,Receptors, Glycine ,Genetics ,medicine ,Humans ,Point Mutation ,Codon ,Molecular Biology ,Gene ,Glycine receptor ,Genetics (clinical) ,Mutation ,Reflex, Abnormal ,General Medicine ,Pedigree ,Genes ,Female - Published
- 2017
4. Franco Regli Stiftung
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Franco Regli Stiftung Fondation Franco Regli
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General Medicine - Published
- 2017
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5. Fondation Franco Regli
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Franco Regli Stiftung Fondation Franco Regli
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Microbiology (medical) ,Immunology ,Immunology and Allergy - Published
- 2017
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6. Intrathecal delivery of CNTF using encapsulated genetically modifiedxenogeneic cells in amyotrophic lateral sclerosis patients
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Ann C. Kato, Moses Goddard, Anne D. Zurn, Jean-Marc Joseph, E. Edward Baetge, Bruno Heyd, Lorenz Hirt, Nicole Déglon, Franco Regli, Joseph P. Hammang, Patrick Aebischer, and Myriam Schluep
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Nervous system ,Pathology ,medicine.medical_specialty ,Cell Transplantation ,Genetic Vectors ,Central nervous system ,Nerve Tissue Proteins ,Pharmacology ,Ciliary neurotrophic factor ,Kidney ,General Biochemistry, Genetics and Molecular Biology ,Cerebrospinal fluid ,Neurotrophic factors ,Cricetinae ,medicine ,Animals ,Humans ,Ciliary Neurotrophic Factor ,Amyotrophic lateral sclerosis ,Injections, Spinal ,Drug Implants ,Lumbar Vertebrae ,biology ,business.industry ,Amyotrophic Lateral Sclerosis ,Genetic Therapy ,General Medicine ,medicine.disease ,Recombinant Proteins ,Genetically modified organism ,medicine.anatomical_structure ,Systemic administration ,biology.protein ,business - Abstract
Neuronal growth factors hold promise for providing therapeutic benefits in various neurological disorders. As a means of ensuring adequate central nervous system delivery of growth factors and minimizing significant adverse side effects associated with systemic delivery methods, we have developed an ex vivo gene therapy approach for protein delivery using encapsulated genetically modified xenogeneic cells. Ciliary neurotrophic factor (CNTF) has been shown in various rodent models to reduce the motor neuron cell death similar to that seen in amyotrophic lateral sclerosis (ALS). The initial trials focusing on the systemic administration of CNTF for ALS have been discontinued as a result of major side effects, thus preventing determination of the potential efficacy of the molecule. In order to deliver CNTF directly to the nervous system, we conducted a phase I study in which six ALS patients were implanted with polymer capsules containing genetically engineered baby hamster kidney cells releasing approximately 0.5 microgram of human CNTF per day in vitro. The CNTF-releasing implants were surgically placed within the lumbar intrathecal space. Nanogram levels of CNTF were measured within the patients' cerebrospinal fluid (CSF) for at least 17 weeks post-transplantation, whereas it was undetectable before implantation. Intrathecal delivery of CNTF was not associated with the limiting side effects observed with systemic delivery. These results demonstrate that neurotrophic factors can be continuously delivered within the CSF of humans by an ex vivo gene therapy approach, opening new avenues for the treatment of neurological diseases.
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- 1996
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7. Gene Therapy for Amyotrophic Lateral Sclerosis (ALS) Using a Polymer Encapsulated Xenogenic Cell Line Engineered to Secrete hCNTF. Lausanne University Medical School, Lausanne, Switzerland
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N. de Tribolet, B. Heyd, Moses Goddard, E. Edward Baetge, Anne D. Zurn, N. A. Pochon, F. Porchet, Nicole Déglon, Franco Regli, Lorenz Hirt, A. C. Kato, Joseph P. Hammang, Patrick Aebischer, Jean-Marc Joseph, M. Lysaght, Myriam Schluep, and F. Kaplan
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Genetic enhancement ,Transfection ,Biology ,Ciliary neurotrophic factor ,Cell biology ,Neurotrophic factors ,Cell culture ,Immunology ,Dihydrofolate reductase ,Genetics ,Baby hamster kidney cell ,biology.protein ,Molecular Medicine ,Secretion ,Molecular Biology - Abstract
The gene therapy approach presented in this protocol employs a polymer encapsulated, xenogenic, transfected cell line to release human ciliary neurotrophic factor (hCNTF) for the treatment of Amyotrophic Lateral Sclerosis (ALS). A tethered device, containing around 10(6) genetically modified cells surrounded by a semipermeable membrane, is implanted intrathecally; it provides for slow continuous release of hCNTF at a rate of 0.25 to 1.0 micrograms/24 hours. The semipermeable membrane prevents immunologic rejection of the cells and interposes a physical, virally impermeable barrier between cells and host. Moreover, the device and the cells it contains may be retrieved in the event of side effects. A vector containing the human CNTF gene was transfected into a line of baby hamster kidney cells (BHK) with calcium phosphate using a dihydrofolate reductase-based selection vector with a SV40 promoter and contains a HSV-tk killer gene. hCNTF is a potent neurotrophic factor which may have utility for the treatment of ALS. Systemic delivery of hCNTF in humans has been frustrated by peripheral side effects, the molecule's short half life, and its inability to cross the blood-brain barrier. The gene therapy approach described in this protocol is expected to mitigate such difficulties by local intrathecal delivery of a known quantity of continuously-synthesized hCNTF from a retrievable implant.
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- 1996
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8. Contents, Vol 35, 1995
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François Vingerhoets, Marie-Luce Royere, Franco Regli, Samantha L. Free, Michel Poncet, M.R.A. Manford, J.G.M. Morris, J.M. Henderson, Julien Bogousslavsky, Ta-Chirn Chen, Leonardo Fiori, Ildebrando Appollonio, Mathieu Ceccaldi, K. Byth, Louis R. Caplan, David R. Fish, Lucio C. Rovati, Shaw-Yi Cheng, Claus Meier, Françoise Delacrétaz, S.P. Stone, Sylvie Belleville, Giuliano Parenti, Lodovico Frattola, Carlo Ferrarese, Maurizio Perego, Peter W. Halligan, John M. Stevens, R.A. Blizzard, D. Levy, Lok-Ming Tang, R. Einstein, Clara Pozzi, R. Piolti, Sien-Tsong Chen, Hans Knecht, Mark J. Cook, Andreas J. Steck, Rong-Kuo Lyu, Thierry Kuntzer, Simon Shorvon, and D.M. Jackson
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Neurology ,Neurology (clinical) - Published
- 1995
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9. Atrial fibrillation after acute stroke
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François Vingerhoets, G. Van Melle, Franco Regli, and Julien Bogousslavsky
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Male ,medicine.medical_specialty ,Heart disease ,Risk Factors ,Internal medicine ,Atrial Fibrillation ,medicine ,Humans ,Registries ,cardiovascular diseases ,Risk factor ,Stroke ,Aged ,Advanced and Specialized Nursing ,Vascular disease ,business.industry ,Cerebral infarction ,Atrial fibrillation ,medicine.disease ,Cerebrovascular Disorders ,Embolism ,Cardiology ,Female ,Neurology (clinical) ,Cardiology and Cardiovascular Medicine ,Complication ,business ,Switzerland - Abstract
Atrial fibrillation (AF) is a risk factor for stroke, although it may not always be directly responsible for the stroke. On the other hand, cardiac arrhythmias and electrocardiographic changes have been reported after ischemic stroke and numerous other intracranial pathologies. We tested the hypothesis that some patients with acute stroke may develop transient AF as a consequence of the stroke. This study was based on 1,661 patients with first-ever stroke consecutively hospitalized and prospectively included into the Lausanne Stroke Registry. "Recent AF" was defined as AF discovered at or after ("after-admission" AF) admission in patients without any previous history of AF. Populations with recent AF and after-admission AF were compared for AF evolution, risk factors, and lesion type and distribution with patients with previous history of AF (known AF) and with patients with another recognized cardiac source of embolism (cardioembolic). Twenty-four patients had recent AF on admission, and 17 developed it a few hours to 3 days after stroke. AF disappeared after a few days in 26 (63%; 94% of after-admission AF) patients. Stroke was a primary hematoma in 9.8% of patients with recent AF, 2.8% of patients with known AF, and 0.9% (p < 0.001) of patients with cardiac source of embolism. Parietoinsular (32%) and brain stem (11%) involvement were more common in recent AF than in cardioembolic stroke in general (16.7% and 6.7%, respectively; p < 0.05). AF discovered after an acute stroke lasted no more than a few days, suggesting that it may have occurred as a consequence of the stroke. This possibility is emphasized by the significant predominance in patients with recent AF of primary hematoma, which cannot be caused by AF, and of parietoinsular and brain stem involvement, which are experimentally known as arrhythmogenic. This hypothesis should be considered in patients with acute stroke and previously unknown AF before therapeutic decisions are made.
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- 1993
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10. Contents Vol. 2, 1992
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A. Molins, G.F. Pezzoli, C. Lindquist, Kjell Asplund, Franco Giubilei, R. Di Cori, Secundino López-Pousa, Takenori Yamaguchi, Theodor Landis, Takashi Tsuchiya, Antonio Dávalos, Jean-Christophe Stauffer, Patrizia Pantano, M.J.J. Buscher, Franco Regli, Michael Daras, Alan J. Tuchman, P Rondepierre, E. de Cendra, Barbara Tettenborn, Carlos Cantú, B. Marino, Stephen Marks, D. Genís, Louis R. Caplan, Nils Wahlgren, A. Rudehill, J.W.J. van Wersch, A. Nègre, G. Soto Ares, Didier Leys, M. Ferrandiz, G. Hellström, C.L. Franke, Julien Bogousslavsky, V. Di Piero, Bernard Nater, O. Godefroy, Masahiro Yasaka, Ralf W. Baumgartner, O. Fustioni, and G. L. Lenzi
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Neurology ,Traditional medicine ,business.industry ,Medicine ,Neurology (clinical) ,Cardiology and Cardiovascular Medicine ,business - Published
- 1992
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11. Contents Vol. 1, 1991
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Franco Regli, Wang Qiu-Yue, Gérard Besson, Hans Herzog, Tohru Sawada, Torsten Kuwert, M. Hennerici, Jan Lodder, Giovanni Pracucci, Julien Bogousslavsky, Mario Mascalchi, Marc Hommel, Domenico Inzitari, Massimo Cadelo, Paul-André Despland, Jelis Boiten, Yin Pu-An, Feng Jing-Chang, Masaichi Nakamura, Matthias Sitzer, John A.P.M. Verhulst, Perret J, Ludwig E. Feinendegen, Hiroaki Naritomi, Albert Hijdra, L. Zografos, Seiji Kazui, Albrecht Aulich, Karl-Josef Langen, Kotaro Miyashita, and C. Miller Fisher
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Neurology ,Traditional medicine ,business.industry ,Medicine ,Neurology (clinical) ,Cardiology and Cardiovascular Medicine ,business - Published
- 1991
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12. Alcohol consumption and carotid atherosclerosis in the Lausanne Stroke Registry
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Julien Bogousslavsky, Franco Regli, Paul-André Despland, and G. Van Melle
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Carotid Artery Diseases ,Male ,medicine.medical_specialty ,Alcohol Drinking ,Disease ,Logistic regression ,Duplex scanning ,Sex Factors ,Risk Factors ,Internal medicine ,medicine.artery ,Diabetes mellitus ,medicine ,Humans ,Registries ,Risk factor ,Stroke ,Aged ,Ultrasonography ,Advanced and Specialized Nursing ,business.industry ,medicine.disease ,Surgery ,Stenosis ,Cardiology ,Regression Analysis ,Female ,Neurology (clinical) ,Internal carotid artery ,Cardiology and Cardiovascular Medicine ,business ,Carotid Artery, Internal - Abstract
We evaluated the association between alcohol consumption and carotid atherosclerosis in 261 consecutive patients greater than 50 years old admitted to our community-based primary-care center with first ischemic stroke; their characteristics were entered into a computerized data bank (Lausanne Stroke Registry). Reported regular alcohol consumption was compared with the presence and severity of internal carotid artery disease as assessed by duplex scanning with spectral analysis of the Doppler signal and real-time B-mode imaging at the level of the carotid bifurcation. We found an inverse linear relation between light-to-moderate alcohol intake (less than or equal to 4 standard drinks/day) and severity of internal carotid artery stenosis. No conclusion could be drawn for heavier drinkers because there were too few. A logistic regression model showed that hypertension, cigarette smoking, and age in men and diabetes mellitus and cigarette smoking in women strongly counterbalanced the potential benefit of alcohol consumption. Although regular alcohol drinking cannot be advocated on the basis of our findings, light-to-moderate consumption of alcohol is the first factor to be inversely associated with extracranial carotid atherosclerosis in symptomatic patients with cerebrovascular disease.
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- 1990
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13. Prolonged hypoperfusion and early stroke after transient ischemic attack
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A Delaloye-Bischof, B. Delaloye, Julien Bogousslavsky, and Franco Regli
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Male ,Time Factors ,Ischemia ,Hemodynamics ,medicine.artery ,medicine ,Humans ,Risk factor ,Stroke ,Aged ,Advanced and Specialized Nursing ,medicine.diagnostic_test ,business.industry ,Middle Aged ,medicine.disease ,Cerebrovascular Disorders ,Stenosis ,Ischemic Attack, Transient ,Cerebrovascular Circulation ,Anesthesia ,Female ,Neurology (clinical) ,Internal carotid artery ,Tomography, X-Ray Computed ,Cardiology and Cardiovascular Medicine ,business ,Perfusion ,Emission computed tomography ,Tomography, Emission-Computed - Abstract
Many patients suffer a stroke early after a transient ischemic attack, but the reason why is often unclear. We studied 12 patients with less than 75% stenosis of the internal carotid artery and a single hemispheric transient ischemic attack lasting less than 1 hour who had a normal neurologic examination 3-13 hours later and a normal computed tomogram 24-36 hours later. Single-photon emission computed tomography using technetium-99m HM-PAO less than or equal to 50 hours after the attack showed no abnormality in eight patients, but in the other four there was an area with 30-50% reduction in perfusion ipsilateral to the transient ischemic attack. Three of these four patients developed an ipsilateral infarct 3-7 days later, but none of the eight patients with normal single-photon emission computed tomograms had a stroke during the following weeks. No difference in therapy, risk factors, severity of internal carotid artery disease, or timing of the technetium-99m study could explain these findings. We suggest that some transient ischemic attacks, though clinically identical to others, may be associated with persisting focal hypoperfusion, which predisposes to early stroke.
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- 1990
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14. Idiopathic orbital inflammation (orbital inflammatory pseudotumour): an unusual cause of transient ischaemic attack
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Franco Regli, H Fankhauser, N Ducrey, R C Janzer, François-Xavier Borruat, and Patrik Vuilleumier
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Adult ,Male ,medicine.medical_specialty ,Pathology ,Eye disease ,Vision Disorders ,Visual Acuity ,Ischemia ,Administration, Oral ,Hemiplegia ,Inflammation ,Central nervous system disease ,Orbital Pseudotumor ,Internal medicine ,Biopsy ,medicine ,Humans ,Cyclophosphamide ,medicine.diagnostic_test ,Vascular disease ,business.industry ,Brain ,Optic Nerve ,medicine.disease ,Psychiatry and Mental health ,Treatment Outcome ,Hemiparesis ,Ischemic Attack, Transient ,Cardiology ,Inflammatory pseudotumor ,Surgery ,Neurology (clinical) ,medicine.symptom ,business ,Orbit ,Carotid Artery, Internal ,Magnetic Resonance Angiography ,Research Article - Abstract
A patient with idiopathic inflammation of the right orbit, established by biopsy, developed episodes of transient left sensorimotor hemiparesis. Neuroimaging showed intracranial extension of the disease with pronounced narrowing of the right internal carotid artery in its intracavernous portion. Oral cyclophosphamide induced gradual improvement. Transient ischaemic attack is rarely found in association with orbital disease and indicates possible intracranial extension.
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- 1995
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15. Parietal kinetic ataxia without proprioceptive deficit
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A Uske, Joseph Ghika, Julien Bogousslavsky, and Franco Regli
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Cerebellum ,Ataxia ,Cerebellar ataxia ,Posterior parietal cortex ,Superior parietal lobule ,Middle Aged ,Proprioception ,Magnetic Resonance Imaging ,Angular gyrus ,Lesion ,Psychiatry and Mental health ,medicine.anatomical_structure ,nervous system ,Parietal Lobe ,medicine ,Humans ,Surgery ,Neurology (clinical) ,medicine.symptom ,Paracentral lobule ,Psychology ,Neuroscience ,Research Article - Abstract
A patient with acute onset "classic" cerebellar ataxia of the right arm without clinically detectable deep sensory loss is reported, in relation to an acute posterior parietal infarct. Wild back and forth swaying of the arm, giving away, or worsening by suppression of vision were not seen. The lesion involved area 5, parts of area 7, the angular gyrus, the middle and posterior parieto-occipital gyri, and posterior parts of the superior and middle temporal gyri. The paracentral lobule, commonly thought to be responsible for parietal ataxia, was spared. Thus posterior parietal lesions can mimick cerebellar ataxia, possibly by severing specific projections to the ventrolateral thalamic nuclei. On the basis of previous studies in primates, the superior parietal gyrus may play a major part in the ataxia presented by this patient.
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- 1995
16. Headache at stroke onset: the Lausanne Stroke Registry
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Julien Bogousslavsky, E Kumral, P. Pierre, Franco Regli, and G. Van Melle
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Adult ,Male ,medicine.medical_specialty ,Adolescent ,Neurological disorder ,Central nervous system disease ,medicine.artery ,Epidemiology ,medicine ,Humans ,cardiovascular diseases ,Registries ,Stroke ,Aged ,Aged, 80 and over ,Analysis of Variance ,business.industry ,Vascular disease ,Headache ,Middle Aged ,medicine.disease ,Psychiatry and Mental health ,Dissection ,Cerebrovascular Disorders ,medicine.anatomical_structure ,Anesthesia ,Middle cerebral artery ,Surgery ,Female ,Neurology (clinical) ,business ,Switzerland ,Artery ,Research Article - Abstract
Within 12 hours of stroke onset 2506 patients with first ever stroke admitted to the Lausanne Stroke Registry were questioned about headache. Eighteen per cent of the patients reported headache, 14% with anterior circulation stroke and 29% with posterior circulation stroke (p < 0.001). Headache was reported by 16% of the patients with infarct and 36% of those with haemorrhage (p < 0.001). The prevalence of headache was 9% with lacunar infarct, 15% with middle cerebral artery territory infarct, 37% with infratentorial haemorrhage, and 36% with supratentorial haemorrhage. The most common topography of pain was frontal (41%), followed by diffuse headache (27%; p < 0.001). Diffuse (41%) or occipital (30%) headache was particularly frequent with posterior circulation stroke, whereas frontal headache was associated with anterior circulation stroke (51%; p < 0.001). Headache in stroke may be explained in part by involvement of blood vessels (acute distention or distortion) and mechanical (stretch of haemorrhage) stimulation of intracranial nociceptive afferents. Stroke due to dissection was strongly associated with headache (p < 0.001), whereas embolic (cardiac, artery to artery) stroke was more common without headache (p < 0.001), emphasising the role of extracranial v intracranial arteries in the genesis of headache at stroke onset. Moreover, dual trigeminal-vascular and cervical-vascular system involvement in causing headache may explain the lack of correspondence with the "rules of referral" in up to 38% of the cases.
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- 1995
17. Acute hemiconcern: a right anterior parietotemporal syndrome
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G Assal, Julien Bogousslavsky, Joseph Ghika, Franco Regli, and E Kumral
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Male ,medicine.medical_specialty ,Lateralization of brain function ,Supramarginal gyrus ,Parietal Lobe ,medicine ,Humans ,Stroke ,Aged ,Behavior ,Postcentral gyrus ,Parietal lobe ,Hemispatial neglect ,Anatomy ,Syndrome ,Middle Aged ,medicine.disease ,Trunk ,Magnetic Resonance Imaging ,Temporal Lobe ,Surgery ,Psychiatry and Mental health ,Cerebrovascular Disorders ,Cerebral hemisphere ,Compulsive Behavior ,Female ,Neurology (clinical) ,medicine.symptom ,Psychology ,Research Article - Abstract
Three patients developed a striking visual and motor behaviour in the acute phase of a stroke involving the territory of the right anterior parietal artery (postcentral gyrus, parts or upper and middle temporal gyri, anterior part of inferior parietal gyrus, and supramarginal gyrus). The patients concentrated on the left side of their bodies, looking at it for long periods and relentlessly rubbing, touching, pinching, pressing, lifting, and manipulating parts of the left arm, trunk, and leg with their right hand or foot. They all had severe loss of elementary sensation on the left (touch, pain, temperature, vibration, position). The behaviour was not associated with overinterest in the left hemispace apart from their own bodies. It lasted no more than a few days, disappearing when left sided sensation improved. The findings suggest an association between sensory dysfunction and this "acute hemiconcern". None of 13 patients with a mirror infarct in the left hemisphere and none of 38 patients with acute hemisensory loss due to thalamic capsular or brainstem stroke showed hemiconcern behaviour. This behaviour may result from a feeling of strangeness critically associated with hemisensory loss without hemispatial neglect, due to involvement of the right anterior parietotemporal region.
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- 1995
18. Infarcts in the territory of the lateral branch of the posterior inferior cerebellar artery
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A Barth, Franco Regli, and Julien Bogousslavsky
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Male ,Cerebellum ,Vertebral artery ,Infarction ,Dysdiadochokinesia ,Cerebellar hemisphere ,medicine.artery ,medicine ,Humans ,cardiovascular diseases ,Aged ,Aged, 80 and over ,business.industry ,Limb ataxia ,Anatomy ,Arteries ,Cerebral Infarction ,Middle Aged ,medicine.disease ,Magnetic Resonance Imaging ,Psychiatry and Mental health ,Posterior inferior cerebellar artery ,medicine.anatomical_structure ,Gait Ataxia ,cardiovascular system ,Surgery ,Female ,Neurology (clinical) ,medicine.symptom ,business ,Research Article - Abstract
The territory of the lateral branch of the posterior inferior cerebellar artery (1PICA) supplies the anterolateral region of the caudal part of the cerebellar hemisphere. Because infarcts in the territory of the 1PICA have rarely been studied specifically, 10 patients with this type of infarct are reported. An 1PICA infarct was isolated in only three patients, whereas it was associated with brainstem infarct in four, with occipital infarct in one, and with multiple infarcts in two patients. The most common symptom at onset was acute unsteadiness and gait ataxia without rotatory vertigo (six patients). Unilateral cerebellar dysfunction was found in all patients, with limb ataxia (nine patients), dysdiadochokinesia (five patients), and ipsilateral body sway (four patients), but dysarthria and primary position nystagmus were notably absent. In the patients with a coexisting infarct in the brainstem, cranial nerve and sensorimotor dysfunction was prominent and often masked the signs of cerebellar dysfunction. Unlike other infarcts in the PICA territory, 1PICA territory infarcts were mainly associated with vertebral artery atherosclerosis (six patients), whereas cardiac embolism was less common (three patients). Unilateral limb ataxia without dysarthria or vestibular signs suggests isolated 1PICA territory infarction and should allow its differentiation from other cerebellar infarcts.
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- 1994
19. Pure amnesia after unilateral left polar thalamic infarct: topographic and sequential neuropsychological and metabolic (PET) correlations
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G Assal, David W. Townsend, S Blecic, Stephanie Clarke, Julien Bogousslavsky, K. L. Leenders, and Franco Regli
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Blood Glucose ,Thalamus ,Amnesia ,Neuropsychological Tests ,Amygdala ,Functional Laterality ,Procedural memory ,Cortex (anatomy) ,medicine ,Humans ,Neurologic Examination ,Memory Disorders ,Cerebral infarction ,Neuropsychology ,Biological Transport ,Cerebral Infarction ,Middle Aged ,medicine.disease ,Magnetic Resonance Imaging ,Psychiatry and Mental health ,medicine.anatomical_structure ,Posterior cingulate ,Female ,Surgery ,Neurology (clinical) ,medicine.symptom ,Psychology ,Neuroscience ,Tomography, Emission-Computed ,Research Article - Abstract
A 54-year-old patient who had an isolated small polar thalamic infarct and acute global amnesia with slight frontal type dysfunction but without other neurological dysfunction was studied. Memory improved partially within 8 months. At all stages the impairment was more severe for verbal than non-verbal memory. Autobiographic recollections and newly acquired information tended to be disorganised with respect to temporal order. Procedural memory was unaffected. Both emotional involvement and pleasure in reading were lost. On MRI, the infarct was limited to the left anterior thalamic nuclei and the adjacent mamillothalamic tract. The regional cerebral metabolic rate of glucose (measured with PET) was decreased on the left in the thalamus, amygdala, and posterior cingulate cortex 2 weeks after the infarct, and in the thalamus and posterior cingulate cortex 9 months later. These findings stress the specific role of the left anterior thalamic region in memory and confirm that longlasting amnesia from a thalamic lesion can occur without significant structural damage to the dorsomedial nucleus. Furthermore, they suggest that the anterior thalamic nuclei and possibly their connections with the posterior cingulate cortex play a role in emotional involvement linked to ipsilateral hemispheric functions.
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- 1994
20. Motor conduction block and high titres of anti-GM1 ganglioside antibodies: pathological evidence of a motor neuropathy in a patient with lower motor neuron syndrome
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Andreas J. Steck, D Adams, Franco Regli, Thierry Kuntzer, R C Janzer, and A Lobrinus
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Male ,Retrograde Degeneration ,Neural Conduction ,Neuromuscular Junction ,Enzyme-Linked Immunosorbent Assay ,G(M1) Ganglioside ,Lower motor neuron ,Neuromuscular junction ,medicine ,Humans ,Peripheral Nerves ,Motor Neuron Disease ,Aged ,Autoantibodies ,Autoimmune disease ,business.industry ,Motor conduction block ,medicine.disease ,Spinal cord ,Immunohistochemistry ,Psychiatry and Mental health ,medicine.anatomical_structure ,nervous system ,Spinal Cord ,Surgery ,Neurology (clinical) ,business ,Neuroscience ,Research Article - Abstract
A patient with a progressive lower motor neuron syndrome and neurophysiological evidence of motor axon loss, multifocal proximal motor nerve conduction block, and high titres of anti-ganglioside GM1 antibodies. Neuropathological findings included a predominantly proximal motor radiculoneuropathy with multifocal IgG and IgM deposits on nerve fibres associated with a loss of spinal motor neurons. These findings support an autoimmune origin of this lower motor neuron syndrome with retrograde degeneration of spinal motor neurons and severe neurogenic muscular atrophy.
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- 1993
21. Vertical gaze palsy and selective unilateral infarction of the rostral interstitial nucleus of the medial longitudinal fasciculus (riMLF)
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Judith Miklossy, Franco Regli, Julien Bogousslavsky, and Janzer Rc
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Eye Movements ,Hemiplegia ,Quadriplegia ,Lesion ,Posterior commissure ,Mesencephalon ,Upgaze palsy ,Tegmentum ,medicine ,Humans ,Dominance, Cerebral ,Red Nucleus ,Palsy ,Ophthalmoplegia ,business.industry ,Cranial Nerves ,Anatomy ,Cerebral Infarction ,Middle Aged ,Medial longitudinal fasciculus ,Psychiatry and Mental health ,Surgery ,Female ,Neurology (clinical) ,Midbrain tegmentum ,Downgaze palsy ,medicine.symptom ,business ,Brain Stem ,Research Article - Abstract
We report a clinico-pathological correlation study in a patient with basilar artery thrombosis, who developed tetraplegia and combined up- and downgaze palsy involving voluntary saccades and visually-guided movements, but sparing the oculocephalic responses. At necropsy, apart from bilateral infarction in the basis pontis, there was a single unilateral infarct selectively destroying the rostral interstitial nucleus of the medial longitudinal fasciculus (riMLF) on the right. The posterior commissure and its nucleus, the nucleus of Cajal, the nucleus of Darkschewitsch and the pontine tegmentum were spared. We suggest that the unilateral riMLF lesion may have disrupted bilateral upgaze excitatory and inhibitory inputs and unilateral downgaze excitatory inputs. The functional anatomy of inhibitory and excitatory vertical gaze circuitry, which remains speculative, may explain why a unilateral lesion of the upper midbrain tegmentum may be sufficient to generate an upgaze palsy or a combined up- and downgaze palsy, while an isolated downgaze palsy requires bilateral lesions.
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- 1990
22. Cervical Epidural Abscess due to Actinomycosis: Demonstration by MRI
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M C Ingvar-Maeder, N de Tribolet, Franco Regli, Reto Meuli, and P. Maeder
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medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,Brain Abscess ,Magnetic resonance imaging ,Middle Aged ,medicine.disease ,Actinomycosis ,Magnetic Resonance Imaging ,Cervical epidural abscess ,Surgery ,Diagnosis, Differential ,Vertebral canal ,Spinal Cord ,Neurology ,Cervical Vertebrae ,medicine ,Actinomyces ,Humans ,Female ,Neurology (clinical) ,Abscess ,business - Published
- 1996
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23. Subject Index Vol. 35, 1995
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Samantha L. Free, Lodovico Frattola, Peter W. Halligan, J.M. Henderson, M.R.A. Manford, Thierry Kuntzer, Simon Shorvon, R.A. Blizzard, Rong-Kuo Lyu, Maurizio Perego, David R. Fish, Claus Meier, J.G.M. Morris, Sylvie Belleville, Carlo Ferrarese, Ta-Chirn Chen, Michel Poncet, Julien Bogousslavsky, Mathieu Ceccaldi, Louis R. Caplan, Lucio C. Rovati, R. Piolti, Andreas J. Steck, Giuliano Parenti, S.P. Stone, Franco Regli, François Vingerhoets, John M. Stevens, Marie-Luce Royere, Lok-Ming Tang, R. Einstein, D. Levy, Hans Knecht, Ildebrando Appollonio, Mark J. Cook, Leonardo Fiori, Clara Pozzi, Sien-Tsong Chen, D.M. Jackson, K. Byth, Françoise Delacrétaz, and Shaw-Yi Cheng
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Cognitive science ,Index (economics) ,Neurology ,Subject (documents) ,Neurology (clinical) ,Psychology ,Cognitive psychology - Published
- 1995
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24. Subject Index Vol. 3, 1993
- Author
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John Bamford, Frank M. Yatsu, Rui de Lima, Mário Mendes, Birgitte H. Bendixen, Jan Lodder, John Burn, Gert-Jan Luijckx, Cesare Fieschi, J. M. Wardlaw, Danilo Toni, Guy van Melle, Jan T. Wilmink, Franco Regli, Harold P. Adams, Gian Luigi Lenzi, Gheorghe A. Pop, Lucio Giuseppe Lazzarino, Luis Castro Guimarães, Peter J. Koudstaal, James C. Torner, Han J. Meeder, L. Jaap Kappelle, Peter Sandercock, Julien Bogousslavsky, Satoshi Kataoka, Jeannette C. van Latum, Wynsen van Oudenaarden, E. Zanette, Jelis Boiten, Wim Verweij, Serge Blecic, Carlo Pozzilli, Aldo Nicolai, Surat Boonyakarnkul, José Pimentel, José M. Ferro, C. Roberti, Charles Warlow, J Cravino, William E. Stehbens, and Martin Dennis
- Subjects
Index (economics) ,Neurology ,business.industry ,Statistics ,Medicine ,Subject (documents) ,Neurology (clinical) ,Cardiology and Cardiovascular Medicine ,business - Published
- 1993
- Full Text
- View/download PDF
25. Chlorambucil fails to improve patients with motor neuropathies and antibodies to gangliosides
- Author
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Franco Regli, Thierry Kuntzer, Andreas J. Steck, and D Adams
- Subjects
Chlorambucil ,biology ,business.industry ,Autoantibody ,Neurotransmission ,Psychiatry and Mental health ,Text mining ,Immunology ,medicine ,biology.protein ,Surgery ,Neurology (clinical) ,Antibody ,business ,Research Article ,medicine.drug - Published
- 1992
- Full Text
- View/download PDF
26. Subject Index Vol. 2, 1992
- Author
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G. Hellström, J.W.J. van Wersch, Michael Daras, Louis R. Caplan, A. Rudehill, Antonio Dávalos, Barbara Tettenborn, C.L. Franke, R. Di Cori, A. Nègre, A. Molins, G.F. Pezzoli, Franco Giubilei, Jean-Christophe Stauffer, Kjell Asplund, Didier Leys, M. Ferrandiz, Alan J. Tuchman, Stephen Marks, Secundino López-Pousa, Takenori Yamaguchi, B. Marino, P Rondepierre, Takashi Tsuchiya, D. Genís, Patrizia Pantano, Carlos Cantú, M.J.J. Buscher, G. Soto Ares, E. de Cendra, Franco Regli, Theodor Landis, O. Godefroy, Nils Wahlgren, Julien Bogousslavsky, O. Fustioni, Bernard Nater, Masahiro Yasaka, Ralf W. Baumgartner, V. Di Piero, G. L. Lenzi, and C. Lindquist
- Subjects
Index (economics) ,Neurology ,business.industry ,Statistics ,Medicine ,Subject (documents) ,Neurology (clinical) ,Cardiology and Cardiovascular Medicine ,business - Published
- 1992
- Full Text
- View/download PDF
27. Subject Index Vol. 1, 1991
- Author
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Perret J, Tohru Sawada, Hiroaki Naritomi, Paul-André Despland, Julien Bogousslavsky, Jelis Boiten, Yin Pu-An, Jan Lodder, C. Miller Fisher, Matthias Sitzer, Franco Regli, Feng Jing-Chang, John A.P.M. Verhulst, Torsten Kuwert, M. Hennerici, Massimo Cadelo, Mario Mascalchi, Karl-Josef Langen, Masaichi Nakamura, Wang Qiu-Yue, Albert Hijdra, Domenico Inzitari, Giovanni Pracucci, Gérard Besson, Marc Hommel, Hans Herzog, Kotaro Miyashita, Ludwig E. Feinendegen, Seiji Kazui, Albrecht Aulich, and L. Zografos
- Subjects
Index (economics) ,Neurology ,business.industry ,Statistics ,Medicine ,Subject (documents) ,Neurology (clinical) ,Cardiology and Cardiovascular Medicine ,business - Published
- 1991
- Full Text
- View/download PDF
28. Transplantation of an encapsulated genetically engineered cell line releasing ciliary neurotrophic factor in LOU gehrig disease
- Author
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E. Edward Baetge, Jean-Marc Joseph, Moses Goddard, Lorenz Hirt, Myriam Schluep, Anne D. Zurn, Patrick Aebischer, N. Degion, O. Martinet, and Franco Regli
- Subjects
Transplantation ,Genetically engineered ,Cell culture ,Biomedical Engineering ,biology.protein ,Cell Biology ,Disease ,Biology ,Ciliary neurotrophic factor ,Neuroscience ,Cell biology - Published
- 1996
- Full Text
- View/download PDF
29. Ad Hoc Reviewers 1994
- Author
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Sture Eriksson, Eckart Altenmüller, Martin Dennis, T Moulin, Tohru Sawada, John Bamford, Didier Leys, Surat Boonyakarnkul, Takenori Yamaguchi, M. Hennerici, Carl Counsell, Geoffrey A. Donnan, Ph. Neuschwander, Norbert Nighoghossian, Hideki Moriyasu, J.C. Getenet, Werner Hacke, Johannes Dichgans, Peter Sandercock, G. Riche, Christine Thomas, Peter J. Koudstaal, Teruo Omae, Tanya Stojkovic, Franco Regli, Seitz R, Masahiro Yasaka, Christianne Steichen-Wiehn, Christof Klötzsch, Joseph Ghika, Per-Olov Wester, Bert-Ove Olofsson, Elizabeth F Jones, Jiro Oita, S. Begey, Anette Immel, John Burn, Peter Berlit, Rolf R. Diehl, Claudia Harer, Armin J. Grau, Julien Bogousslavsky, Didier Chavot, Paul Trouillas, and Charles Warlow
- Subjects
Neurology ,business.industry ,Applied psychology ,Medicine ,Neurology (clinical) ,Cardiology and Cardiovascular Medicine ,business - Published
- 1995
- Full Text
- View/download PDF
30. Ad Hoc Reviewers (1992)
- Author
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Erik Hägg, Maria Gabriella Ceravolo, Harold P. Adams, Werner Hacke, rard Besson, Bernard Nater, Teresa Pinho e Melo, Tommy Olsson, Kjell Asplund, Leandro Provinciali, Yngve Gustafson, Julien Bogousslavsky, E. Berthier, Klaus Rieke, Timo Erkinjuntti, Vladimir Hachinski, Michael D. O'Brien, Franco Regli, J D Easton, Uta Meyding-Lamadé, Alfred Aschoff, Paolo Minciotti, C. Bourrat, Derk W. Krieger, and John C.M. Brust
- Subjects
Neurology ,business.industry ,Applied psychology ,Medicine ,Neurology (clinical) ,Cardiology and Cardiovascular Medicine ,business - Published
- 1993
- Full Text
- View/download PDF
31. The syndrome of unilateral tuberothalamic artery territory infarction
- Author
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Franco Regli, Julien Bogousslavsky, and G. Assal
- Subjects
Male ,medicine.medical_specialty ,Thalamus ,Neuropsychological Tests ,Functional Laterality ,Thalamic Disease ,Thalamic Diseases ,Visual memory ,Internal medicine ,medicine.artery ,Aphasia ,Humans ,Medicine ,Posterior communicating artery ,Aged ,Advanced and Specialized Nursing ,Memory Disorders ,business.industry ,Cerebral infarction ,Hemispatial neglect ,Cerebral Infarction ,Syndrome ,Middle Aged ,medicine.disease ,Surgery ,Acute Disease ,Acalculia ,Cardiology ,Female ,Neurology (clinical) ,medicine.symptom ,Tomography, X-Ray Computed ,Cardiology and Cardiovascular Medicine ,business ,Dejerine–Roussy syndrome - Abstract
The study of 3 personal cases and 5 published cases of unilateral infarct limited to the territory of the tuberothalamic artery suggests that this syndrome should be differentiated from the other thalamic syndromes. The onset is usually sudden, with moderate contralateral weakness. Sensory changes may be present but remain mild. The patients are apathetic, show perseveration and may be disoriented. In left-sided infarcts, transcortical aphasia, verbal and visual memory impairment and sometimes acalculia are found. In right-sided infarcts, hemispatial neglect, visual memory impairment and disturbed visuospatial processing are common. A decreased level of consciousness, disturbed ocular movements, severe motor weakness and delayed abnormal movements do not occur. Involvement of the ventral lateral and dorsomedial nucleus with sparing of the intralaminar nuclei, posterolateral formation and upper midbrain may explain this picture. The fact that the tuberothalamic artery arises from the posterior communicating artery, which often receives its supply from the carotid system, further justifies considering unilateral tuberothalamic infarcts as a syndrome.
- Published
- 1986
- Full Text
- View/download PDF
32. Delayed TIAs distal to bilateral occlusion of carotid arteries -- evidence for embolic and hemodynamic mechanisms
- Author
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Franco Regli and Julien Bogousslavsky
- Subjects
Carotid Artery Diseases ,Male ,medicine.medical_specialty ,Carotid arteries ,Ischemia ,Hemodynamics ,Arterial Occlusive Diseases ,Orthostatic vital signs ,Internal medicine ,medicine.artery ,Occlusion ,medicine ,Humans ,cardiovascular diseases ,Common carotid artery ,Aged ,Advanced and Specialized Nursing ,business.industry ,Intracranial Embolism and Thrombosis ,Middle Aged ,medicine.disease ,Radiography ,Stenosis ,medicine.anatomical_structure ,Ischemic Attack, Transient ,cardiovascular system ,Cardiology ,Female ,Neurology (clinical) ,Cardiology and Cardiovascular Medicine ,business ,Artery - Abstract
We studied 4 patients with bilateral carotid artery occlusion who suffered delayed TIAs in one of the occluded internal carotid or common carotid areas. Hemodynamic mechanisms were prominent in two patients, in head turning and orthostatic hypotension. In the other two cases, embolic phenomena through the homolateral external carotid collateral pathways were probable, because this artery (or the common carotid artery) showed atheromatous stenosis and major collateral supply to the brain and retina. Different mechanisms may be responsible for further ischemia after bilateral occlusion of carotid arteries.
- Published
- 1983
- Full Text
- View/download PDF
33. Leukoencephalopathy in patients with ischemic stroke
- Author
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Julien Bogousslavsky, Franco Regli, and Antoine Uske
- Subjects
Male ,Risk ,medicine.medical_specialty ,Hematocrit ,Brain Ischemia ,Leukoencephalopathy ,White matter ,Internal medicine ,Diabetes mellitus ,Occlusion ,Humans ,Medicine ,Aged ,Retrospective Studies ,Advanced and Specialized Nursing ,medicine.diagnostic_test ,business.industry ,Leukoencephalopathy, Progressive Multifocal ,medicine.disease ,Surgery ,Stenosis ,Blood pressure ,medicine.anatomical_structure ,Hypertension ,Cardiology ,Female ,Neurology (clinical) ,Tomography, X-Ray Computed ,Cardiology and Cardiovascular Medicine ,business ,Electrocardiography - Abstract
Thirty-one (16 women, 15 men; mean age 68 years) of 1,000 consecutive patients with an ischemic stroke investigated systematically with computed tomography (CT), Doppler, electrocardiography (ECG), and biological tests had a diffuse hypodensity of the cerebral hemispheric white matter on CT, a sign indicative of leukoencephalopathy. In 25 of the 31 patients, the acute infarct was deep. Leukoencephalopathy was more frequent in patients with a deep infarct (8%) than in patients in whom the cortex was involved (0.8%) (p less than 0.01). A history of progressive intellectual impairment (23%) and the finding of a mild or moderate impairment, or severe dementia (84%) were more frequent in study patients (p less than 0.05) than in 31 sex- and age-matched controls with an acute infarct of same size and topography but without leukoencephalopathy. A history of hypertension (81%) and high blood pressure on admission (166 +/- 19/96 +/- 12 mm Hg) were the most common risk factors and were more frequent in study patients (p less than 0.05) than in controls. On the other hand, study patients had a greater than or equal to 50% stenosis or occlusion of the carotid artery (13%) less often than controls (35%) (p less than 0.05). Diabetes (23%), elevated blood cholesterol (13%), hematocrit greater than 45% (23%), smoking (32%), and myocardial ischemia by history or ECG (45%) did not differ. These findings suggest that hypertension may be more strongly associated with leukoencephalopathy than with deep infarcts. In acute stroke patients, leukoencephalopathy on CT should not be considered a fortuitous finding.
- Published
- 1987
- Full Text
- View/download PDF
34. Transient ischemic attacks and external carotid artery. A retrospective study of 23 patients with an occlusion of the internal carotid artery
- Author
-
Franco Regli, Julien Bogousslavsky, R Chrzanowski, and J P Hungerbühler
- Subjects
Adult ,Carotid Artery Diseases ,Male ,medicine.medical_specialty ,External carotid artery ,Collateral Circulation ,Arterial Occlusive Diseases ,medicine.artery ,Internal medicine ,Occlusion ,medicine ,Humans ,cardiovascular diseases ,Stroke ,Aged ,Retrospective Studies ,Advanced and Specialized Nursing ,medicine.diagnostic_test ,business.industry ,Middle Aged ,Collateral circulation ,medicine.disease ,Stenosis ,medicine.anatomical_structure ,Ischemic Attack, Transient ,Angiography ,cardiovascular system ,Cardiology ,Female ,Neurology (clinical) ,Radiology ,Internal carotid artery ,Cardiology and Cardiovascular Medicine ,business ,Artery - Abstract
Twenty-three patients with occlusion of an internal carotid artery have been followed 5 to 50 months after angiography. None had a later permanent stroke. Eight had delayed TIAs in the occluded internal carotid area, never in another area. In these TIAs the role of the homolateral external carotid artery is emphasized, because in the 8 cases this artery was the main collateral to the occluded internal carotid, and angiography had shown atheromatous stenosis of homolateral external/common carotid arteries or an irregular stump at the site of the occlusion. Hemodynamic and embolic mechanisms are discussed, especially the latter, because of the absence of severe stenosis and evidence of emboligenic plaques.
- Published
- 1981
- Full Text
- View/download PDF
35. Chiasmal apoplexy: haemorrhage from a cavernous malformation in the optic chiasm
- Author
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Julien Bogousslavsky, Franco Regli, Luca Regli, and N de Tribolet
- Subjects
Adult ,medicine.medical_specialty ,genetic structures ,Optic chiasm ,Diagnosis, Differential ,Angioma ,Vision disorder ,Humans ,Medicine ,Cerebral Hemorrhage ,medicine.diagnostic_test ,business.industry ,Vascular malformation ,Magnetic resonance imaging ,Cerebral Arteries ,medicine.disease ,Magnetic Resonance Imaging ,eye diseases ,Surgery ,Visual field ,Cerebrovascular Disorders ,Psychiatry and Mental health ,medicine.anatomical_structure ,Optic Chiasm ,Optic chiasma ,Female ,Neurology (clinical) ,Differential diagnosis ,medicine.symptom ,business ,Research Article - Abstract
We present a patient who experienced sudden onset of orbital headache, visual loss and bitemporal visual field defect. MRI of the optic chiasm suggested a diagnosis of haemorrhage and hence a vascular malformation. Pterional craniotomy revealed an intrachiasmatic haematoma with a cavernous angioma. The malformation was totally excised and vision improved after surgery. The syndrome of chiasmal apoplexy is discussed.
- Published
- 1989
- Full Text
- View/download PDF
36. Subacute myelopathy as the presenting manifestation of sarcoidosis
- Author
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H J Graf, Franco Regli, J Bogousslavsky, and J P Hungerbühler
- Subjects
Adult ,Male ,Baclofen ,Pathology ,medicine.medical_specialty ,Neurology ,Sarcoidosis ,Spinal cord involvement ,Asymptomatic ,Spinal Cord Diseases ,Diagnosis, Differential ,Myelopathy ,medicine ,Humans ,Neuroradiology ,medicine.diagnostic_test ,business.industry ,Interventional radiology ,medicine.disease ,Dermatology ,Prednisone ,Surgery ,Neurology (clinical) ,Neurosurgery ,medicine.symptom ,business - Abstract
We studied a patient with progressive myelopathy, in whom systemic sarcoidosis was discovered. Involvement of other organs was asymptomatic. The myelopathy considerably improved after corticosteroid therapy. Spinal cord involvement in sarcoidosis is very uncommon, and its occurrence as a presenting manifestation is even rarer. Prompt recognition is emphasized, because it is a treatable condition.
- Published
- 1982
- Full Text
- View/download PDF
37. Manic delirium and frontal-like syndrome with paramedian infarction of the right thalamus
- Author
-
Ferrazzini M, H Tanabe, A Delaloye-Bischof, G Assal, Franco Regli, and Julien Bogousslavsky
- Subjects
Bipolar Disorder ,Thalamus ,Infarction ,Neuropsychological Tests ,behavioral disciplines and activities ,Ventral lateral nucleus ,Limbic system ,medicine ,Humans ,Dominance, Cerebral ,Aged ,Afferent Pathways ,Cerebral infarction ,business.industry ,Delirium ,Cerebral Infarction ,medicine.disease ,Frontal Lobe ,Psychiatry and Mental health ,medicine.anatomical_structure ,Frontal lobe ,Disinhibition ,Female ,Surgery ,Neurology (clinical) ,medicine.symptom ,Tomography, X-Ray Computed ,business ,Neuroscience ,Tomography, Emission-Computed ,Research Article - Abstract
A disinhibition syndrome affecting speech (with logorrhoea, delirium, jokes, laughs, inappropriate comments, extraordinary confabulations), was the main manifestation of a right-sided thalamic infarct involving the dorsomedian nucleus, intralaminar nuclei and medial part of the ventral lateral nucleus. Resolution of conflicting tasks was severely impaired, suggesting frontal lobe dysfunction. These abnormalities correlated with the finding on SPECT of a marked hypoperfusion in the overlying hemisphere predominating in the frontal region. We suggest that this behavioural syndrome was produced by disconnecting the dorsomedian nucleus from the frontal lobe and limbic system.
- Published
- 1988
- Full Text
- View/download PDF
38. Responses of Surface Arteries and Blood Flow of Ischemic and Nonischemic Cerebral Cortex to Aminophylline, Ergotamine Tartrate, and Acetazolamide
- Author
-
Takenori Yamaguchi, Arthur G. Waltz, and Franco Regli
- Subjects
Cerebral arteries ,Constriction ,medicine.artery ,Ergotamine ,medicine ,Animals ,Vasoconstrictor Agents ,Carbonic Anhydrase Inhibitors ,Tartrates ,Acid-Base Equilibrium ,Advanced and Specialized Nursing ,business.industry ,Carbon Dioxide ,Cerebral Arteries ,Aminophylline ,Acetazolamide ,medicine.anatomical_structure ,Ergotamine Tartrate ,Ischemic Attack, Transient ,Cerebral cortex ,Cerebrovascular Circulation ,Anesthesia ,Middle cerebral artery ,Cats ,cardiovascular system ,Neurology (clinical) ,Blood Gas Analysis ,Cardiology and Cardiovascular Medicine ,business ,circulatory and respiratory physiology ,medicine.drug - Abstract
In cats in which one middle cerebral artery was occluded, cortical blood flow (CBF) was measured and the superficial cortical microvasculature was observed bilaterally before and after the intravenous injection of a vasoactive drug. Aminophylline produced decreased CBF in the nonischemic cerebral hemispheres of five of seven animals and arterial constriction in three. Ergotamine tartrate produced arterial constriction in the nonischemic hemispheres of four animals and decreased CBF in three. Neither drug consistently produced increased CBF in ischemic cerebral tissue. Acetazolamide caused vasodilatation in the nonischemic hemispheres of seven animals and increased CBF in five. Increased CBF was not due entirely to changes of Pa CO 2 . CBF also increased in ischemic hemispheres of four of the seven animals given acetazolamide.
- Published
- 1971
- Full Text
- View/download PDF
39. Isolation of speech area from focal brain ischemia
- Author
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G. Assal, Julien Bogousslavsky, and Franco Regli
- Subjects
Carotid Artery Diseases ,Male ,medicine.medical_specialty ,Cerebral arteries ,Computed tomography ,Speech Disorders ,Brain ischemia ,Mixed transcortical aphasia ,Internal medicine ,medicine ,Humans ,cardiovascular diseases ,Aged ,Advanced and Specialized Nursing ,medicine.diagnostic_test ,business.industry ,Atrial fibrillation ,Cerebral Infarction ,medicine.disease ,Anesthesia ,cardiovascular system ,Cardiology ,Neurology (clinical) ,Internal carotid artery occlusion ,Precentral Artery ,Tomography, X-Ray Computed ,Cardiology and Cardiovascular Medicine ,business ,Dominant hemisphere - Abstract
A patient with atrial fibrillation and internal carotid artery occlusion developed mixed transcortical aphasia. The CT scan showed two recent distinct infarcts in the dominant hemisphere, one in the precentral artery area (pial artery infarct) and one in the borderzone area between the posterior and middle cerebral arteries territories (watershed infarct). The perisylvian speech areas were spared, but probably disconnected from other areas by the infarcts. The syndrome of isolation of speech area may be caused by vascular conditions which are able to produce simultaneous pial artery and watershed infarcts, and is not necessarily related to more extensive processes of the brain.
- Published
- 1985
- Full Text
- View/download PDF
40. Unilateral occipital infarction: evaluation of the risks of developing bilateral loss of vision
- Author
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Julien Bogousslavsky, G. Van Melle, and Franco Regli
- Subjects
Adult ,Male ,Risk ,medicine.medical_specialty ,Infarction ,Posterior cerebral artery ,Vascular risk ,Blindness ,Text mining ,medicine.artery ,medicine ,Humans ,Dominance, Cerebral ,Aged ,business.industry ,Cortical blindness ,Cerebral Infarction ,Middle Aged ,medicine.disease ,Surgery ,Visual field ,Psychiatry and Mental health ,Female ,Occipital Lobe ,Neurology (clinical) ,Visual Fields ,business ,Psychology ,Medical therapy ,Research Article ,Follow-Up Studies - Abstract
Fifty-eight patients with a unilateral infarction in the superficial area supplied by a posterior cerebral artery were followed (mean: 39.6 months). Thirteen (22.4%) developed cortical blindness associated with a delayed contralateral occipital infarction. Advanced age, general vascular risk, a history of strokes, Sylvian border-zone extension of the initial infarct, and an absence of improvement of initial visual field defects were strongly associated with spread to the other side. The lack of visual field improvement most accurately predicted a high risk of cortical blindness. A careful follow-up and controlled medical therapy is particularly indicated in these patients.
- Published
- 1983
- Full Text
- View/download PDF
41. One-and-a-half syndrome in ischaemic locked-in state: a clinico-pathological study
- Author
-
Paul-André Despland, Judith Miklossy, J P Deruaz, Franco Regli, and Julien Bogousslavsky
- Subjects
Male ,genetic structures ,Eye Movements ,Internuclear ophthalmoplegia ,Reticular formation ,Quadriplegia ,Abducens nucleus ,Pons ,Fasciculus ,Neural Pathways ,medicine ,Saccades ,Humans ,One and a half syndrome ,Dominance, Cerebral ,Palsy ,Ophthalmoplegia ,biology ,Reticular Formation ,Cranial Nerves ,Brain ,Horizontal gaze palsy ,Paramedian pontine reticular formation ,Anatomy ,Cerebral Infarction ,Cerebral Arteries ,Middle Aged ,medicine.disease ,biology.organism_classification ,eye diseases ,Psychiatry and Mental health ,medicine.anatomical_structure ,Surgery ,Neurology (clinical) ,Psychology ,Tomography, X-Ray Computed ,Research Article - Abstract
Five patients with "locked-in" syndrome and dysconjugate palsy of horizontal gaze were studied. In all cases internuclear ophthalmoplegia due to dysfunction or destruction of the median longitudinal fasciculus was combined with an ipsilateral gaze palsy, producing the "one-and-a-half" syndrome. Clinical and electro-oculographic examination suggested involvement of the paramedian pontine reticular formation when all ipsilateral saccades were abolished, when exotropia of the contralateral eye was present, and when vestibular stimulation showed full conjugate deviation to the damaged side. Involvement of the abducens nucleus was suggested when the palsy of ipsilateral gaze was not dissociated on vestibular stimulation. In three cases these clinical deductions were confirmed by the pathological study, which showed a corresponding destruction of the median longitudinal fasciculus, paramedian pontine reticular formation and abducens nucleus. In one case the one-and-a-half syndrome evolved into a total horizontal gaze palsy, which corresponded to involvement of the abducens nucleus contralateral to the initially destroyed paramedian pontine reticular formation. Vertical oculocephalic response disappeared, because of destruction of the median longitudinal fasciculus on both sides (bilateral internuclear ophthalmoplegia). Patients with the locked-in syndrome provide a unique situation in which complex pontine oculomotor disturbances may be studied, because consciousness is preserved. In these patients, dissociated and dysconjugate oculomotor palsy may have been underestimated.
- Published
- 1984
42. Unilateral left paramedian infarction of thalamus and midbrain: a clinico-pathological study
- Author
-
G Assal, Franco Regli, Julien Bogousslavsky, J P Deruaz, and Judith Miklossy
- Subjects
Anterograde amnesia ,Thalamus ,Reticular formation ,Ventral lateral nucleus ,Midbrain ,Lesion ,Posterior commissure ,Mesencephalon ,Upgaze palsy ,medicine ,Humans ,Paralysis ,Aged ,business.industry ,Reticular Formation ,Anatomy ,Cerebral Infarction ,Intracranial Embolism and Thrombosis ,Psychiatry and Mental health ,nervous system ,Surgery ,Female ,Neurology (clinical) ,medicine.symptom ,business ,Research Article - Abstract
In a patient with a unilateral embolic infarct in the left posterior thalamo-subthalamic paramedian artery territory, neuropathological studies showed involvement of the intralaminar, dorsomedial, and internal part of the ventral posterior nuclei of the thalamus, of the rostral part of the mesencephalic reticular formation, and of the posterior commissure. The patient showed upgaze palsy for voluntary saccades, smooth pursuit and vestibulo-ocular movements, sustained downgaze, right-sided motor hemineglect and facio-brachial hypaesthesia, motor transcortical aphasia and anterograde amnesia. This case confirms that unilateral destruction of the posterior commissure, rostral interstitial nucleus of the MLF and interstitial nucleus of Cajal produces a non-dissociated upgaze palsy. Involvement of the nucleus of Cajal probably produced the sustained downward deviation of the eye, by causing predominance of downward vestibulo-ocular inputs. This case also shows that thalamic aphasia and anterograde amnesia may be related to a paramedian lesion of the thalamus, with special reference to involvement of the dorsomedial nucleus, in the absence of lesion of the pulvinar and mamillo-thalamic tract and of conspicuous involvement of the ventral lateral nucleus. Selective hemineglect for motor tasks may occur in infarction of the dominant thalamus, involving the intralaminar nuclei.
- Published
- 1986
43. Neuropathy, amyloidosis, and monoclonal gammopathy
- Author
-
J W Fitting, Albert Bischoff, Franco Regli, and G. de Crousaz
- Subjects
Male ,Wallerian degeneration ,Pathology ,medicine.medical_specialty ,Amyloid ,Sural nerve ,Immunoglobulin kappa-Chains ,Immunoglobulin lambda-Chains ,Sural Nerve ,Gammopathy ,Hypergammaglobulinemia ,medicine ,Humans ,Peripheral Nerves ,Pathological ,Cytoskeleton ,Aged ,business.industry ,Amyloidosis ,Peripheral Nervous System Diseases ,Middle Aged ,medicine.disease ,Psychiatry and Mental health ,Monoclonal gammopathy ,Microscopy, Electron ,nervous system ,Surgery ,Neurology (clinical) ,medicine.symptom ,business ,Research Article - Abstract
Three cases of neuropathy with monoclonal gammopathy and amyloid deposits in peripheral nerves are described. They appeared to present a benign gammopathy because of the duration of the neuropathy in the absence of any clinical or biological sign of myeloma or macroglobulinaemia. The pathological abnormality found in the sural nerves of the three patients was characterised by a marked loss of myelinated and unmyelinated nerve fibres because of active axonal degeneration with Wallerian degeneration. The most striking feature in all three cases was the finding of deposits identified as an accumulation of microfibrils.
- Published
- 1979
44. Lingual and fusiform gyri in visual processing: a clinico-pathologic study of superior altitudinal hemianopia
- Author
-
G Assal, Judith Miklossy, Julien Bogousslavsky, Franco Regli, and J P Deruaz
- Subjects
Male ,medicine.medical_specialty ,genetic structures ,Audiology ,behavioral disciplines and activities ,Lingual gyrus ,Necrosis ,Visual memory ,medicine ,Humans ,Visual Pathways ,Aged ,Brain Mapping ,Fusiform gyrus ,Cognitive neuroscience of visual object recognition ,Limbic lobe ,Cerebral Infarction ,Fusiform face area ,eye diseases ,Psychiatry and Mental health ,medicine.anatomical_structure ,nervous system ,Visual Perception ,Hemianopsia ,Surgery ,Neurology (clinical) ,Occipital Lobe ,Visual Fields ,Occipital lobe ,Psychology ,Parahippocampal gyrus ,psychological phenomena and processes ,Cognitive psychology ,Research Article - Abstract
A macular-sparing superior altitudinal hemianopia with no visuo-psychic disturbance, except impaired visual learning, was associated with bilateral ischaemic necrosis of the lingual gyrus and only partial involvement of the fusiform gyrus on the left side. It is suggested that bilateral destruction of the lingual gyrus alone is not sufficient to affect complex visual processing. The fusiform gyrus probably has a critical role in colour integration, visuo-spatial processing, facial recognition and corresponding visual imagery. Involvement of the occipitotemporal projection system deep to the lingual gyri probably explained visual memory dysfunction, by a visuo-limbic disconnection. Impaired verbal memory may have been due to posterior involvement of the parahippocampal gyrus and underlying white matter, which may have disconnected the intact speech areas from the left medial temporal structures.
- Published
- 1987
45. Prognosis of high-risk patients with nonoperated symptomatic extracranial carotid tight stenosis
- Author
-
Julien Bogousslavsky, Paul-André Despland, and Franco Regli
- Subjects
Carotid Artery Diseases ,Male ,medicine.medical_specialty ,medicine.medical_treatment ,Arterial Occlusive Diseases ,Aortic aneurysm ,Risk Factors ,Diabetes mellitus ,Internal medicine ,medicine.artery ,Occlusion ,medicine ,Humans ,cardiovascular diseases ,Stroke ,Endarterectomy ,Aged ,Advanced and Specialized Nursing ,business.industry ,Mortality rate ,Middle Aged ,medicine.disease ,Prognosis ,Surgery ,Stenosis ,Cerebrovascular Disorders ,cardiovascular system ,Cardiology ,Female ,Neurology (clinical) ,Internal carotid artery ,Cardiology and Cardiovascular Medicine ,business ,Carotid Artery, Internal - Abstract
Forty-five patients with symptomatic (20 with transient ischemic attack, 25 with minor stroke) greater than or equal to 75% stenosis of the cervical internal carotid artery had no endarterectomy and received only medical therapy because the surgical risks (severe cardiac disease, chronic obstructive pulmonary disease, hypertension or diabetes with systemic complications, aortic aneurysm) were believed to be unacceptable. During follow-up (mean 48 months), occlusion of the internal carotid artery developed without symptoms in two patients and with symptoms in three patients. The cumulative stroke and/or death rate was 24% at 2 years and 50% at 6 years. The ipsilateral infarct rate was 10% after the first year, but decreased markedly thereafter (2.4% per year), and one third of these infarcts were probably lacunes due to hypertensive small vessel disease. Overall, stroke related to previously symptomatic internal carotid artery stenosis was not the major problem during follow-up but was largely overcome by other strokes and cardiac death.
- Published
- 1988
46. The Lausanne Stroke Registry: analysis of 1,000 consecutive patients with first stroke
- Author
-
G. Van Melle, Julien Bogousslavsky, and Franco Regli
- Subjects
Adult ,medicine.medical_specialty ,Pediatrics ,Risk Factors ,Epidemiology ,Medicine ,Humans ,cardiovascular diseases ,Registries ,Risk factor ,Stroke ,Aged ,Cerebral Hemorrhage ,Advanced and Specialized Nursing ,Aged, 80 and over ,medicine.diagnostic_test ,business.industry ,Cerebral infarction ,Cerebral Infarction ,Middle Aged ,medicine.disease ,Cerebral Angiography ,Cerebrovascular Disorders ,Ischemic Attack, Transient ,Angiography ,Etiology ,Neurology (clinical) ,Nervous System Diseases ,Cardiology and Cardiovascular Medicine ,business ,Tomography, X-Ray Computed ,Electrocardiography ,Cerebral angiography - Abstract
We present epidemiologic, etiologic, and clinical data for 1,000 consecutive patients with a first stroke (cerebral infarction or hemorrhage) admitted to the Centre Hospitalier Universitaire Vaudois since 1982. The patients were evaluated using a standard protocol of tests (computed tomography, Doppler ultrasonography, and electrocardiography in all patients, as well as angiography and specific cardiac investigations in selected patients). Each case was coded prospectively into a computerized registry. We believe that the Lausanne Stroke Registry is the first registry with complete computed tomography and Doppler ultrasonography data on all patients, which allows correlation between clinical findings, presumed etiology, and stroke location. Although the Lausanne Stroke Registry is not population-based, it gives a good estimate of the stroke-related problems in patients admitted to a primary-care center since our hospital is the sole acute-care facility for stroke in the Lausanne area.
- Published
- 1988
47. Benign outcome in unoperated large cerebellar haemorrhage. Report of 2 cases
- Author
-
Xavier Jeanrenaud, Franco Regli, and Julien Bogousslavsky
- Subjects
Male ,medicine.medical_specialty ,Cerebellum ,Neurology ,Ataxia ,Cerebellar haemorrhage ,Cerebellar Diseases ,medicine ,Humans ,Neuroradiology ,Aged ,Cerebral Hemorrhage ,medicine.diagnostic_test ,business.industry ,Interventional radiology ,Prognosis ,Autopsy series ,Surgery ,medicine.anatomical_structure ,Anesthesia ,Neurology (clinical) ,Neurosurgery ,medicine.symptom ,business ,Tomography, X-Ray Computed - Abstract
We studied two patients with large cerebellar haemorrhages, who were conscious on admission and did not deteriorate during the following days. Surgical decompression was not performed and the patients regained their former level of activity, except for moderate persisting ataxia. We suggest that cerebellar haemorrhage may have a benign spontaneous outcome, more often than previously assumed from autopsy series. The main selection criteria for surgery is an impaired state of consciousness and evidence of neurological worsening. Taken alone, the size of the haemorrhage on computerized tomography is not a reliable criterion for surgery.
- Published
- 1984
48. Effects of inhalation of oxygen on blood flow and microvasculature of ischemic and nonischemic cerebral cortex
- Author
-
Franco Regli, Arthur G. Waltz, and Takenori Yamaguchi
- Subjects
medicine.medical_specialty ,Constriction ,Oxygen Consumption ,Cortex (anatomy) ,Internal medicine ,medicine ,Animals ,Advanced and Specialized Nursing ,Hyperoxia ,Cerebral Cortex ,Radioisotopes ,business.industry ,Cerebral infarction ,Microcirculation ,Krypton ,Blood flow ,Venous blood ,Carbon Dioxide ,Cerebral Arteries ,medicine.disease ,Oxygen ,Cerebrovascular Disorders ,Disease Models, Animal ,medicine.anatomical_structure ,Cerebral cortex ,Infarction ,Ischemic Attack, Transient ,Anesthesia ,Cerebrovascular Circulation ,Circulatory system ,Cardiology ,Cats ,Neurology (clinical) ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,business ,Blood Flow Velocity - Abstract
The right middle cerebral artery was occluded in cats, and Pa o o2 was increased by increasing the amount of oxygen inhaled by the animals at atmospheric pressure. Cortical blood flow (CBF) was measured with Krypton-85, and observations and photographs of the superficial cortical microvasculature were made bilaterally. In two of five animals, increasing the Pa o o2 caused constriction of surface arterioles of the nonischemic hemispheres, with an associated decrease of CBF; in the three other animals, there were no circulatory responses to the increased Pa o o2 . In seven animals, increasing the Pa o o2 had no apparent effect on CBF or arteriolar caliber of the ischemic cerebral hemispheres. In four animals, at Pa o o2 greater than 400 torr, reactivity to increases of Pa CO CO2 was preserved in nonischemic cortex but impaired in ischemic cortex. Reddening of venous blood of the microvasculature of ischemic cerebral cortex occurred when Pa o o2 was increased, indicating that more oxygen was made available to the ischemic cerebral tissue. However, no beneficial effects could be demonstrated on the changes in the microvasculature produced by ischemia.
- Published
- 1970
49. Effect of PaCO2 on hyperemia and ischemia in experimental cerebral infarction
- Author
-
Arthur G. Waltz, Takenori Yamaguchi, and Franco Regli
- Subjects
Partial Pressure ,Cerebral arteries ,Ischemia ,Hyperemia ,Hypercapnia ,Hypocapnia ,medicine.artery ,medicine ,Animals ,Reactive hyperemia ,Advanced and Specialized Nursing ,CATS ,Cerebral infarction ,business.industry ,Carbon Dioxide ,Cerebral Arteries ,medicine.disease ,Cerebrovascular Disorders ,Cerebral blood flow ,Anesthesia ,Cerebrovascular Circulation ,Middle cerebral artery ,Cats ,Autoradiography ,Neurology (clinical) ,Cardiology and Cardiovascular Medicine ,business - Abstract
To assess the effects of Pa CO CO 2 on cerebral ischemia and reactive hyperemia, the right middle cerebral artery was occluded in 18 cats. Four to six hours later, Pa CO 2 was adjusted by mechanical ventilation, with or without CO 2 , to less than 20 torr in four cats, 31 to 38 torr in six, and 46 to 68 torr in eight. Regional cerebral blood flow (CBF) then was measured at multiple sites in each hemisphere by autoradiography. In regions of brain tissue outside the distribution of the occluded middle cerebral artery, log 10 CBF correlated positively with Pa CO CO 2 . In ischemic regions, CBF was higher in normocapnic cats. Reactive hyperemia occurred in two cats of the hypocapnic group, in four cats of the normocapnic group, but in only one hypercapnic cat (Pa CO CO 2 = 46 torr). Hyperemia also was found outside potentially ischemic regions in five cats. Multiple hyperemic foci developed in six cats. Neither hypocapnia nor hypercapnia was associated with a smaller size or higher CBF of regions of cerebral ischemia produced by occlusion of a middle cerebral artery, although hypercapnia inhibited the development of hyperemia.
- Published
- 1971
50. Effects of acetazolamide on cerebral ischemia and infarction after experimental occlusion of middle cerebral artery
- Author
-
Franco Regli, Takenori Yamaguchi, and Arthur G. Waltz
- Subjects
Ischemia ,Brain Edema ,Hyperemia ,Cerebral edema ,Cerebral circulation ,medicine.artery ,medicine ,Animals ,Cerebral perfusion pressure ,Reactive hyperemia ,Intracranial pressure ,Carbonic Anhydrases ,Advanced and Specialized Nursing ,Carbon Isotopes ,business.industry ,Carbon Dioxide ,Cerebral Arteries ,Hydrogen-Ion Concentration ,medicine.disease ,Acetazolamide ,Oxygen ,Cerebrovascular Disorders ,Cerebral blood flow ,Ischemic Attack, Transient ,Anesthesia ,Cerebrovascular Circulation ,Middle cerebral artery ,cardiovascular system ,Cats ,Autoradiography ,Neurology (clinical) ,Cardiology and Cardiovascular Medicine ,business ,circulatory and respiratory physiology - Abstract
Acetazolamide was given to five of ten cats for 48 to 54 hours after extradural occlusion of a middle cerebral artery (MCA). At seven to eight days later, measurements of regional cerebral blood flow (CBF) and estimates of the sizes of the ischemic and infarcted areas of the brains were made. Neurological deficits were more severe and the ischemic and infarcted regions were larger in the cats given acetazolamide. Cerebral edema (brain swelling) was present and reactive hyperemia was common in the treated cats, even one week after MCA occlusion. The hypercapnia and decreases of pH of nonischemic brain tissue that are caused by acetazolamide are harmful for ischemic brain tissue, presumably because of vasodilatation in nonischemic brain tissue with resultant increases of intracranial pressure and decreases of CBF of ischemic regions.
- Published
- 1971
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