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1. Abstract 10481: The Effect of Current Smoking on Platelet Reactivity Measures by Point-of-Care Methods in Patients Treated With and Without Clopidogrel

Author

Nicolau, Jose C, Salsoso, Rocio, Dalcoquio, Talia, Gurbel, Paul A, Tantry, Udaya, Giugliano, Robert, Nakashima, Carlos A, Franci, Andre, Rizzo, Paulo, menezes, fernando, Guardieiro, Bruno, Scanavini Filho, Marco Antonio, Ferrari, Aline G, Pereira, Cesar, Arantes, Flavia B, Barbosa, Carlos, Bertolin, Adriadne, and Furtado, Remo

Published
2022
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3. Effects of exercise on platelet reactivity after myocardial infarction: a randomized clinical trial.

Author

Falcão Dalçóquio, Talia, Alves dos Santos, Mayara, Silva Alves, Leandro, Brito Arantes, Flávia Bittar, Ferreira-Santos, Larissa, Pinto Brandão Rondon, Maria Urbana, Furtado, Remo Holanda M., Ferrari, Aline Gehlen, Rizzo, Paulo Roberto Genestreti, Salsoso, Rocio, Franci, Andre, Moreira Baracioli, Luciano, de Nazare Nunes Alves, Maria Janieire, Eduardo Negrão, Carlos, and Carlos Nicolau, José

Subjects
MYOCARDIAL infarction, CLINICAL trials, BLOOD platelets, EXERCISE tests, CARDIOVASCULAR diseases risk factors, ADENOSINE diphosphate
Abstract

Exercise training (ET) can lower platelet reactivity in patients with cardiovascular risk factors. However, the effects of ET on platelet reactivity in higher-risk patients is unknown. The aim of this study was to evaluate the effects of ET on platelet reactivity in patients with recent myocardial infarction (MI). Ninety patients were randomly assigned 1 month post-MI to the intervention (patients submitted to a supervised ET program) or control group. All patients were on dual antiplatelet therapy (DAPT). Platelet reactivity by VerifyNow-P2Y12 (measured by P2Y12 reaction units - PRUs) test was determined at baseline and at the end of 14 ± 2 weeks of follow-up at rest (primary endpoint), and multiplate electrode aggregometry (MEA) adenosine diphosphate (ADP) and aspirin (ASPI) tests were performed immediately before and after the maximal cardiopulmonary exercise test (CPET) at the same time points (secondary endpoints). Sixty-five patients (mean age 58.9 ± 10 years; 73.8% men; 60% ST elevation MI) completed follow-up (control group, n = 31; intervention group, n = 34). At the end of the follow-up, the mean platelet reactivity was 172.8 ± 68.9 PRUs and 166.9 ± 65.1 PRUs for the control and intervention groups, respectively (p = .72). Platelet reactivity was significantly increased after the CPET compared to rest at the beginning and at the end of the 14-week follow-up (among the intervention groups) by the MEA-ADP and MEA-ASPI tests (p < .01 for all analyses). In post-MI patients on DAPT, 14 weeks of supervised ET did not reduce platelet reactivity. Moreover, platelet reactivity was increased after highintensity exercise (ClinicalTrials.gov: NCT02958657; https://clinicaltrials.gov/ct2/show/NCT02958657). [ABSTRACT FROM AUTHOR]

Published
2023
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4. Effects of DPP4 Inhibitor in Platelet Reactivity and Other Cardiac Risk Markers in Patients with Type 2 Diabetes and Acute Myocardial Infarction

Author

Genestreti, Paulo R. Rizzo, primary, Furtado, Remo H. M., additional, Salsoso, Rocio, additional, Dalçóquio, Talia F., additional, Franci, Andre, additional, Menezes, Fernando R., additional, Caporrino, Cesar, additional, Ferrari, Aline G., additional, Nakashima, Carlos A. K., additional, Scanavini Filho, Marco A., additional, Lima, Felipe G., additional, Giraldez, Roberto R. C. V., additional, Baracioli, Luciano M., additional, and Nicolau, Jose C., additional

Published
2022
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5. Effects of exercise on platelet reactivity after myocardial infarction: a randomized clinical trial.

Author

Dalçóquio, Talia Falcão, Alves dos Santos, Mayara, Silva Alves, Leandro, Bittar Brito Arantes, Flávia, Ferreira-Santos, Larissa, Pinto Brandão Rondon, Maria Urbana, Furtado, Remo Holanda M, Gehlen Ferrari, Aline, Genestreti Rizzo, Paulo Roberto, Salsoso, Rocio, Franci, Andre, Moreira Baracioli, Luciano, de Nazare Nunes Alves, Maria Janieire, Negrão, Carlos Eduardo, and Nicolau, José Carlos

Subjects
MYOCARDIAL infarction, CLINICAL trials, BLOOD platelets, CARDIOVASCULAR diseases risk factors, EXERCISE tests, PLATELET aggregation inhibitors
Abstract

Exercise training (ET) can lower platelet reactivity in patients with cardiovascular risk factors. However, the effects of ET on platelet reactivity in higher-risk patients is unknown. The aim of this study was to evaluate the effects of ET on platelet reactivity in patients with recent myocardial infarction (MI). Ninety patients were randomly assigned 1 month post-MI to the intervention (patients submitted to a supervised ET program) or control group. All patients were on dual antiplatelet therapy (DAPT). Platelet reactivity by VerifyNow-P2Y12 (measured by P2Y12 reaction units – PRUs) test was determined at baseline and at the end of 14 ± 2 weeks of follow-up at rest (primary endpoint), and multiplate electrode aggregometry (MEA) adenosine diphosphate (ADP) and aspirin (ASPI) tests were performed immediately before and after the maximal cardiopulmonary exercise test (CPET) at the same time points (secondary endpoints). Sixty-five patients (mean age 58.9 ± 10 years; 73.8% men; 60% ST elevation MI) completed follow-up (control group, n = 31; intervention group, n = 34). At the end of the follow-up, the mean platelet reactivity was 172.8 ± 68.9 PRUs and 166.9 ± 65.1 PRUs for the control and intervention groups, respectively (p =.72). Platelet reactivity was significantly increased after the CPET compared to rest at the beginning and at the end of the 14-week follow-up (among the intervention groups) by the MEA-ADP and MEA-ASPI tests (p <.01 for all analyses). In post-MI patients on DAPT, 14 weeks of supervised ET did not reduce platelet reactivity. Moreover, platelet reactivity was increased after high-intensity exercise (ClinicalTrials.gov: NCT02958657; ). What is the context? Platelet reactivity is reduced after exercise training in healthy individuals and patients with cardiovascular risk factors, but the effect in higher-risk patients is unknown. High-intensity exercise in untrained individuals increases platelet reactivity. The effect of dual antiplatelet therapy in inhibiting exercise-induced hyperreactivity is poorly understood. What's new? Exercise training did not reduce platelet reactivity in post-myocardial infarction patients. High-intensity exercise increased platelet reactivity in post-myocardial infarction patients on dual antiplatelet therapy. Exercise training did not attenuate the exercise-induced increase in platelet reactivity. What's the impact? The study suggests that strenuous exercise, if indicated, should be applied carefully to patients with high risk of recurrent ischemic events, even if on optimal medical therapy and after being trained. [ABSTRACT FROM AUTHOR]

Published
2023
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6. Abstract 13782: Platelet Aggregation and Adenosine Levels Among Patients With Stable Chronic Coronary Artery Disease Taking Ticagrelor or Prasugrel

Author

Menezes, Fernando, primary, Furtado, Remo, additional, Dalçóquio, Talia, additional, Genestreti, Paulo, additional, Bertolin, Adriadne, additional, Baracioli, Luciano, additional, Scanavini, Marco, additional, oliveira, beatriz, additional, Franci, Andre, additional, Silva, Marli, additional, Roggerio, Alessandra, additional, Ferrari, Aline G, additional, Lima, Viviane, additional, Pereira, Cesar, additional, Nakashima, Carlos A, additional, Strunz, Celia, additional, Salsoso, Rocio, additional, Soffiatti, Carla, additional, Baldo, Vanessa, additional, and Nicolau, Jose C, additional

Published
2021
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7. Diretrizes da Sociedade Brasileira de Cardiologia sobre Angina Instável e Infarto Agudo do Miocárdio sem Supradesnível do Segmento ST – 2021

Author

Nicolau, José Carlos, primary, Feitosa, Gilson Soares, additional, Petriz, João Luiz, additional, Furtado, Remo Holanda de Mendonça, additional, Précoma, Dalton Bertolim, additional, Lemke, Walmor, additional, Lopes, Renato Delascio, additional, Timerman, Ari, additional, Marin, José A., additional, Bezerra, Luiz, additional, Gomes, Bruno Ferraz de Oliveira, additional, Santos, Eduardo Cavalcanti Lapa, additional, Piegas, Leopoldo Soares, additional, Soeiro, Alexandre de Matos, additional, Negri, Alexandre Jorge de Andrade, additional, Franci, Andre, additional, Markman, Brivaldo, additional, Baccaro, Bruno Mendonça, additional, Montenegro, Carlos Eduardo Lucena, additional, Rochitte, Carlos Eduardo, additional, Barbosa, Carlos José Dornas Gonçalves, additional, Virgens, Cláudio Marcelo Bittencourt das, additional, Stefanini, Edson, additional, Manenti, Euler Roberto Fernandes, additional, Lima, Felipe Gallego, additional, Monteiro, Francisco das Chagas, additional, Correa, Harry, additional, Pena, Henrique Patrus Mundim, additional, Pinto, Ibraim Masciarelli Francisco, additional, Falcão, João Luiz de Alencar Araripe, additional, Sena, Joberto Pinheiro, additional, Peixoto, José Maria, additional, Souza, Juliana Ascenção de, additional, Silva, Leonardo Sara da, additional, Maia, Lilia Nigro, additional, Ohe, Louis Nakayama, additional, Baracioli, Luciano Moreira, additional, Dallan, Luís Alberto de Oliveira, additional, Dallan, Luis Augusto Palma, additional, Mattos, Luiz Alberto Piva e, additional, Bodanese, Luiz Carlos, additional, Ritt, Luiz Eduardo Fonteles, additional, Canesin, Manoel Fernandes, additional, Rivas, Marcelo Bueno da Silva, additional, Franken, Marcelo, additional, Magalhães, Marcos José Gomes, additional, Oliveira, Múcio Tavares de, additional, Filgueiras, Nivaldo Menezes, additional, Dutra, Oscar Pereira, additional, Coelho, Otávio Rizzi, additional, Leães, Paulo Ernesto, additional, Rossi, Paulo Roberto Ferreira, additional, Soares, Paulo Rogério, additional, Lemos, Pedro Alves, additional, Farsky, Pedro Silvio, additional, Cavalcanti, Rafael Rebêlo C., additional, Alves, Renato Jorge, additional, Kalil, Renato Abdala Karam, additional, Esporcatte, Roberto, additional, Marino, Roberto Luiz, additional, Giraldez, Roberto Rocha Corrêa Veiga, additional, Meneghelo, Romeu Sérgio, additional, Lima, Ronaldo de Souza Leão, additional, Ramos, Rui Fernando, additional, Falcão, Sandra Nivea dos Reis Saraiva, additional, Dalçóquio, Talia Falcão, additional, Lemke, Viviana de Mello Guzzo, additional, Chalela, William Azem, additional, and Mathias, Wilson, additional

Published
2021
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8. SAFETY AND EFFICACY OF DPP4 INHIBITORS IN ACUTE MYOCARDIAL INFARCTION: A BIOMARKER DRIVEN DOUBLE-BLINDED RANDOMIZED CONTROLLED TRIAL

Author

Genestreti, Paulo Rizzo, primary, Furtado, Remo, additional, Salsoso, Rocío, additional, Dalcoquio, Talia, additional, Nakashima, Carlos, additional, Lima, Viviane, additional, Colodetti, Raiza, additional, Ferrari, Aline, additional, Franci, Andre, additional, Menezes, Fernando, additional, Baracioli, Luciano, additional, and Nicolau, Jose, additional

Published
2021
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10. INFLUENCE OF HEALTH INSURANCE ON LONG-TERM ADHERENCE TO STATINS AND BETA-BLOCKERS AFTER ACUTE CORONARY SYNDROMES

Author

Nicolau, Jose Carlos, primary, Salsoso, Rocío, additional, Dalcoquio, Talia, additional, Genestreti, Paulo, additional, Franci, Andre, additional, Ferrari, Aline, additional, Bertolin, Adriadne, additional, Lara, Livia, additional, Juliasz, Marcela, additional, Pereira, Cesar, additional, Lima, Felipe, additional, Baracioli, Luciano, additional, Giraldez, Roberto, additional, and Furtado, Remo, additional

Published
2021
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11. Factors associated with actively working in the very long-term following acute coronary syndrome

Author

Nicolau, Jose C., primary, Furtado, Remo H.M., additional, Dalçóquio, Talia F., additional, Lara, Livia M., additional, Juliasz, Marcela G., additional, Ferrari, Aline G., additional, Nakashima, Carlos A.K., additional, Franci, Andre, additional, Pereira, Cesar A.C., additional, Lima, Felipe G., additional, Giraldez, Roberto R., additional, Salsoso, Rocío, additional, Baracioli, Luciano M., additional, and Goodman, Shaun, additional

Published
2021
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12. IMPACT OF HIGH LIPOPROTEIN(A) LEVELS ON PLATELET AGGREGABILITY IN PATIENTS WITH STABLE CORONARY ARTERY DISEASE

Author

Salsoso, Rocío, primary, Dalçóquio, Talia, additional, Furtado, Remo, additional, Franci, Andre, additional, Barbosa, Carlos, additional, Genestreti, Paulo, additional, Ferreira, Mayara Reis Cardoso, additional, Strunz, Celia, additional, Baracioli, Luciano, additional, Maranhão, Raul Cavalcante, additional, and Nicolau, Jose Carlos, additional

Published
2020
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13. INCREASED BODYWEIGHT AND INADEQUATE RESPONSE TO ASPIRIN IN INDIVIDUALS WITH CORONARY ARTERY DISEASE

Author

de Mendonca Furtado, Remo Holanda, primary, Arantes, Flavia, additional, Barbosa, Carlos, additional, Franci, Andre, additional, Menezes, Fernando, additional, Salsoso, Rocio, additional, Dalcoquio, Talia, additional, Nakashima, Carlos, additional, Filho, Marco Scanavini, additional, Ferrari, Aline, additional, Genestreti, Paulo, additional, Baracioli, Luciano, additional, and Nicolau, Jose C., additional

Published
2019
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14. EFFECTS OF LOW MOLECULAR WEIGHT HEPARIN VERSUS DABIGATRAN ON PLATELET AGGREGATION IN PATIENTS WITH STABLE CORONARY ARTERY DISEASE

Author

Arantes, Flavia Bittar Britto, primary, Menezes, Fernando, additional, Franci, Andre, additional, Barbosa, Carlos, additional, Dalçoquio, Talia F., additional, Nakashima, Carlos K., additional, Ferrari, Aline, additional, Filho, Marco Scanavini, additional, Furtado, Remo, additional, Baracioli, Luciano, additional, Ramires, Jose, additional, Kalil-Filho, Roberto, additional, and Nicolau, Jose, additional

Published
2017
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15. PLATELET AGGREGABILITY, COAGULATION, FIBRINOLYSIS AND INFLAMMATION IN PATIENTS WITH CORONARY ARTERY DISEASE AND PREVIOUS CEREBROVASCULAR ISCHEMIC EVENT

Author

Barbosa, Carlos José Dornas Gonçalves, primary, Barreiros, Renata, additional, Franci, Andre, additional, Furtado, Remo, additional, Arantes, Flavia, additional, Strunz, Célia, additional, Tania, Rocha, additional, Ramires, Jose Antonio F., additional, Kalil-Filho, Roberto, additional, and Nicolau, Jose, additional

Published
2017
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16. INFLUENCE OF GLYCEMIC CONTROL ON CLOPIDOGREL RESPONSE IN PATIENTS WITH STABLE CORONARY ARTERY DISEASE: A SUB-ANALYSIS FROM A RANDOMIZED, DOUBLE-BLIND STUDY

Author

de Mendonca Furtado, Remo Holanda, primary, Barbosa, Carlos, additional, Strunz, Celia, additional, Franci, Andre, additional, Menezes, Fernando, additional, Arantes, Flavia, additional, Amico, Elbio D, additional, Rocha, Tania Rubia Flores, additional, Genestreti, Paulo, additional, and Nicolau, Jose, additional

Published
2015
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18. Do Diabetic Patients with Acute Coronary Syndromes Have a Higher Threshold for Ischemic Pain?

Author

Nicolau, José Carlos, Barbosa, Carlos José Dornas Gonçalves, Franci, André, Baracioli, Luciano Moreira, Franken, Marcelo, Lima, Felipe Gallego, Giraldez, Roberto Rocha, Kalil Filho, Roberto, Ramires, José Antônio Franchini, and Giugliano, Robert P.

Subjects
Diabetes Mellitus, Acute Coronary Syndrome, Chest Pain, Hyperglycemia
Abstract

Background: Data from over 4 decades have reported a higher incidence of silent infarction among patients with diabetes mellitus (DM), but recent publications have shown conflicting results regarding the correlation between DM and presence of pain in patients with acute coronary syndromes (ACS). Objective: Our primary objective was to analyze the association between DM and precordial pain at hospital arrival. Secondary analyses evaluated the association between hyperglycemia and precordial pain at presentation, and the subgroup of patients presenting within 6 hours of symptom onset. Methods: We analyzed a prospectively designed registry of 3,544 patients with ACS admitted to a Coronary Care Unit of a tertiary hospital. We developed multivariable models to adjust for potential confounders. Results: Patients with precordial pain were less likely to have DM (30.3%) than those without pain (34.0%; unadjusted p = 0.029), but this difference was not significant after multivariable adjustment, for the global population (p = 0.84), and for subset of patients that presented within 6 hours from symptom onset (p = 0.51). In contrast, precordial pain was more likely among patients with hyperglycemia (41.2% vs 37.0% without hyperglycemia, p = 0.035) in the overall population and also among those who presented within 6 hours (41.6% vs. 32.3%, p = 0.001). Adjusted models showed an independent association between hyperglycemia and pain at presentation, especially among patients who presented within 6 hours (OR = 1.41, p = 0.008). Conclusion: In this non-selected ACS population, there was no correlation between DM and hospital presentation without precordial pain. Moreover, hyperglycemia correlated significantly with pain at presentation, especially in the population that arrived within 6 hours from symptom onset.

Published
2014
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19. Abstract 12938: Adenosine Plasmatic Concentration in Coronary Artery Disease Patients With and Without Chronic Kidney Disease

Author

Franci, Andre, Barbosa, Carlos, Dalcoquio, Talia, Salsoso, Rocio, Furtado, Remo H, Strunz, Celia, Genestreti, Paulo, Lima, Viviane, Scanavini, Marco, Ferrari, Aline G, Baracioli, Luciano, and Nicolau, Jose C

Abstract

Introduction:In the PLATO trial, ticagrelor reduced ischemic events when compared to clopidogrel in patients (pts) with acute coronary syndromes. Increase in adenosine plasmatic concentration (APC) has emerged as a potential mechanism to explain such benefit. Moreover, chronic kidney disease (CKD) pts seemed to have even greater benefit with ticagrelor when compared with non-CKD pts, and this is not fully explained. Adenosine has been linked to important effects such as vasodilation, inflammatory modulation, coordination between kidney blood flow and glomerular filtration rate (GFR), among others. APC has been evaluated in different populations, although no data on pts with CKD (GFR < 60 ml/min/1.73m2) is available.Hypothesis:Whether APC is different in coronary artery disease (CAD) pts with and without CKD.Methods:We analyzed baseline data from 65 pts prospectively included in a single-center randomized clinical trial testing clopidogrel vs. ticagrelor in CAD pts with and without CKD. APC was measured before (data presented here) and after intervention, by high-performance liquid chromatography. Student?s t-test and Mann-Whitney were used for univariate analyses and linear regression models correlating APC with creatinine or GFR was also performed.Results:From the total 65 pts included, 33 were in the CKD group (age 71?5years, 70% men, GFR 41?13 ml/min) and 23 pts in the non-CKD group (age 70?5 years, 66% men, GFR 83?15 ml/min). Both groups were comparable for most baseline characteristics (hypertension, diabetes, dyslipidemia, tobacco use, previous myocardial infarction, previous PCI), except that CKD pts had lower ejection fraction (46?13% vs 54?10%; p=0.005). For the main results, mean APC was not significantly different between CKD and non-CKD pts (141?164 vs 139?104 nmol/L; p=0.21), and no independent association was found between APC and creatinine (p=0.11) or APC and GFR (p=0.54).Conclusion:In the first report ever made evaluating APC in CAD pts according to renal function, we did not find any significant difference of APC in pts with or without CKD. Whether the benefit of ticagrelor previously seen in this population was mediated predominantly by platelet inhibition or also by increase in APC should be clarified in further studies.

Published
2019
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20. Brazilian Society of Cardiology Guidelines on Unstable Angina and Acute Myocardial Infarction without ST-Segment Elevation - 2021.

Author

Nicolau JC, Feitosa Filho GS, Petriz JL, Furtado RHM, Précoma DB, Lemke W, Lopes RD, Timerman A, Marin Neto JA, Bezerra Neto L, Gomes BFO, Santos ECL, Piegas LS, Soeiro AM, Negri AJA, Franci A, Markman Filho B, Baccaro BM, Montenegro CEL, Rochitte CE, Barbosa CJDG, Virgens CMBD, Stefanini E, Manenti ERF, Lima FG, Monteiro Júnior FDC, Correa Filho H, Pena HPM, Pinto IMF, Falcão JLAA, Sena JP, Peixoto JM, Souza JA, Silva LSD, Maia LN, Ohe LN, Baracioli LM, Dallan LAO, Dallan LAP, Mattos LAPE, Bodanese LC, Ritt LEF, Canesin MF, Rivas MBDS, Franken M, Magalhães MJG, Oliveira Júnior MT, Filgueiras Filho NM, Dutra OP, Coelho OR, Leães PE, Rossi PRF, Soares PR, Lemos Neto PA, Farsky PS, Cavalcanti RRC, Alves RJ, Kalil RAK, Esporcatte R, Marino RL, Giraldez RRCV, Meneghelo RS, Lima RSL, Ramos RF, Falcão SNDRS, Dalçóquio TF, Lemke VMG, Chalela WA, and Mathias Júnior W

Subjects
Angina, Unstable diagnosis, Angina, Unstable therapy, Brazil, Electrocardiography, Humans, Cardiology, Myocardial Infarction therapy
Published
2021
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