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7 results on '"Fra, Joaquin"'

1. Abstract 5416: RNA-seq and proteomics to identify response to immunotherapy in advanced melanoma: a Spanish Melanoma Group Study

Author

Trilla-Fuertes, Lucia, primary, Prado-Vazquez, Guillermo, additional, Gámez-Pozo, Angelo, additional, Lopez-Vacas, Rocio, additional, Herrera, Maria Isabel Lumbreras, additional, Soriano, Virtudes, additional, Garicano, Fernando, additional, Lecumberri, Maria Jose, additional, Rodriguez, Maria, additional, Majem, Margarita, additional, Perez, Elisabeth, additional, Gonzalez-Cao, Maria, additional, Oramas, Juana, additional, Magdaleno, Alejandra, additional, Fra, Joaquin, additional, Martin, Alfonso, additional, Corral, Monica, additional, Puertolas, Teresa, additional, Vara, Juan Angel Fresno, additional, and Espinosa, Enrique, additional

Published
2022
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2. Phosphorylated-insulin growth factor I receptor (p-IGF1R) and metalloproteinase-3 (MMP3) expression in advanced gastrointestinal stromal tumors (GIST). A GEIS 19 study

Author

Maurel, Joan, primary, López-Pousa, Antonio, additional, Calabuig, Silvia, additional, Bagué, Silvia, additional, del Muro, Xavier Garcia, additional, Sanjuan, Xavier, additional, Rubió-Casadevall, Jordi, additional, Cuatrecasas, Miriam, additional, Martinez-Trufero, Javier, additional, Horndler, Carlos, additional, Fra, Joaquin, additional, Valverde, Claudia, additional, Redondo, Andrés, additional, Poveda, Andrés, additional, Sevilla, Isabel, additional, Lainez, Nuria, additional, Rubini, Michele, additional, García-Albéniz, Xabier, additional, Martín-Broto, Javier, additional, and de Alava, Enrique, additional

Published
2016
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3. Pulmonary toxicity in patients treated with gemcitabine plus vinorelbine or docetaxel for advanced non-small cell lung cancer: outcome data on a randomized phase II study.

Author

Esteban, Emilio, Villanueva, Noemi, Muñiz, Isabel, Fernández, Yolanda, Fra, Joaquin, Luque, Maria, Jiménez, Paula, Llorente, Beatriz, Capelan, Marta, Vieitez, José M, Estrada, Enrique, Buesa, José M, Jiménez-Lacave, Angel, Esteban, Emilio, Villanueva, Noemi, Muñiz, Isabel, Fernández, Yolanda, Fra, Joaquin, Luque, Maria, Jiménez, Paula, Llorente, Beatriz, Capelan, Marta, Vieitez, José M, Estrada, Enrique, Buesa, José M, and Jiménez-Lacave, Angel

Abstract

Studies with the gemcitabine/vinorelbine (GV) or the gemcitabine/docetaxel (GD) combinations have shown similar efficacy and less toxicity compared to platinum-based chemotherapies, in patients with advanced non-small-cell lung cancer (NSCLC). The present trial was designed to test the efficacy and safety of both, GV and GD, combinations. Chemotherapy-naïve patients (n=39)or=60% and adequate hematological, renal and hepatic function were randomly assigned to receive G 1,000 mg/m2+either V 25 mg/m2 or D 35 mg/m2 (all of which were administered i.v.) on days 1 and 8 every 21 days. Baseline characteristics were comparable in GV (n=20) and GD (n=19) groups. Results indicated objective response of 7 (35%) vs 6 (31%) patients and median time-to-treatment failure of 120 versus 90 days in the GV and GD arms, respectively. The most common non-hematological toxicities were (GV vs GD): grade 2-4 pulmonary toxicity in 1 (5%) vs 7 (37%); grade 2-3 diarrhea 0 versus 4 (21%) and edema 1 (5%) vs 3 (16%); grade 3-4 hematological toxicities occurred in 3 (15%) vs 1 (5%) patients. Our results indicate that the combination of gemcitabine/docetaxel does not have a favorable safety profile with this schedule of administration, particularly in terms of pulmonary toxicity., Clinical Trial, Phase II, Journal Article, Randomized Controlled Trial, info:eu-repo/semantics/published

Published
2008

4. P2-318: Activity of intravenous Topotecan in patients with advanced non-small cell lung cancer pre-treatred with platinum and taxanes: Results of the first analysis

Author

Villanueva, Noemi, primary, Esteban, Emilio, additional, Llorente, Beatriz, additional, Fernández, Yolanda, additional, Jimenez, Paula, additional, Capelan, Marta, additional, Fra, Joaquin, additional, Vieitez, Jose María, additional, Muñiz, Isabel, additional, and Lacave, Angel J., additional

Published
2007
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5. P2-254: Pulmonary toxicity in patients treated with a combination of gemcitabine (G) associated to docetaxel (D) or vinorelbine (V) for advanced non-small cell lung cancer (NSCLC): outcome data on a randomized phase II study

Author

Esteban, Emilio, primary, Villanueva, Noemi, additional, Muñiz, Isabel, additional, Fernández, Yolanda, additional, Fra, Joaquin, additional, Luque, Maria, additional, Jimenez, Paula, additional, Llorente, Beatriz, additional, Capelan, Marta, additional, and Lacave, Angel J., additional

Published
2007
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