82 results on '"Fordham M"'
Search Results
2. The Impact of Elevated CO₂ on Growth and Photosynthesis in Agrostis canina L. ssp. monteluccii Adapted to Contrasting Atmospheric CO₂ Concentrations
- Author
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Fordham, M., Barnes, J. D., Polle, A., Miglietta, F., and Raschi, A.
- Published
- 1997
3. An Evaluation of Confocal versus Conventional Imaging of Biological Structures by Fluorescence Light Microscopy
- Author
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White, J. G., Amos, W. B., and Fordham, M.
- Published
- 1987
4. Some new Asilidae from Western Australia
- Author
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Dakin, William J, Fordham, M G G, and BioStor
- Published
- 1922
5. The impact of elevated CO2 on growth and photosynthesis in Agrostis canina L. ssp. monteluccii adapted to contrasting atmospheric CO2 concentrations
- Author
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Barnes, J. D., Bettarini, I., Polle, A., Slee, N., Raines, C., Miglietta, F., Raschi, A., and Fordham, M.
- Published
- 1997
- Full Text
- View/download PDF
6. Short-term changes in carbon-isotope discrimination in the C3-CAM intermediate Clusia minor L. growing in Trinidad
- Author
-
Borland, A. M., Griffiths, H., Broadmeadow, M. S. J., Fordham, M. C., and Maxwell, C.
- Published
- 1993
- Full Text
- View/download PDF
7. MANTRA: a serious game improving knowledge of maternal and neonatal health and geohazards in Nepal
- Author
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Mueller, S, primary, Soriano, D, primary, Boscor, A, primary, Saville, N M, primary, Arjyal, A, primary, Baral, S, primary, Fordham, M, primary, Hearn, G J, primary, Kayastha, R, primary, and Kostkova, P, primary
- Published
- 2019
- Full Text
- View/download PDF
8. Resilience, the limits of adaptation and the need for transformation in the context of multiple flood events in Central Europe
- Author
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Deeming, H., Fordham, M., Kuhlicke, C., Pedoth, L., Schneiderbauer, S., Shreve, C., Kuhlicke, Christian, Begg, Chloe, Kunath, Anna, Beyer, Maximilian, Deeming, H., Fordham, M., Kuhlicke, C., Pedoth, L., Schneiderbauer, S., Shreve, C., Kuhlicke, Christian, Begg, Chloe, Kunath, Anna, and Beyer, Maximilian
- Abstract
An essential guide to the foundations, research and practices of community disaster resilience Framing Community Disaster Resilience offers a guide to the theories, research and approaches for addressing the complexity of community resilience towards hazardous events or disasters. The text draws on the activities and achievements of the project emBRACE: Building Resilience Amongst Communities in Europe. The authors identify the key dimensions of resilience across a range of disciplines and domains and present an analysis of community characteristics, networks, behaviour and practices in specific test cases. The text contains an in-depth exploration of five test cases whose communities are facing impacts triggered by different hazards, namely: river floods in Germany, earthquakes in Turkey, landslides in South Tyrol, Italy, heat-waves in London and combined fluvial and pluvial floods in Northumberland and Cumbria. The authors examine the data and indicators of past events in order to assess current situations and to tackle the dynamics of community resilience. In addition, they put the focus on empirical analysis to explore the resilience concept and to test the usage of indicators for describing community resilience. This important text: * Merges the forces of research knowledge, networking and practices in order to understand community disaster resilience * Contains the results of the acclaimed project Building Resilience Amongst Communities in Europe - emBRACE * Explores the key dimensions of community resilience * Includes five illustrative case studies from European communities that face various hazards Written for undergraduate students, postgraduates and researchers of social science, and policymakers, Framing Community Disaster Resilience reports on the findings of an important study to reveal the most effective approaches to enhancing community resilience. The emBRACE research received funding from the European Community's Seventh Framework Programme FP7/200
- Published
- 2019
9. Framing community disaster resilience: resources, capacities, learning, and action
- Author
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Deeming, H., Fordham, M., Kuhlicke, Christian, Pedoth, L., Schneiderbauer, S., Shreve, C., Deeming, H., Fordham, M., Kuhlicke, Christian, Pedoth, L., Schneiderbauer, S., and Shreve, C.
- Abstract
An essential guide to the foundations, research and practices of community disaster resilience Framing Community Disaster Resilience offers a guide to the theories, research and approaches for addressing the complexity of community resilience towards hazardous events or disasters. The text draws on the activities and achievements of the project emBRACE: Building Resilience Amongst Communities in Europe. The authors identify the key dimensions of resilience across a range of disciplines and domains and present an analysis of community characteristics, networks, behaviour and practices in specific test cases. The text contains an in-depth exploration of five test cases whose communities are facing impacts triggered by different hazards, namely: river floods in Germany, earthquakes in Turkey, landslides in South Tyrol, Italy, heat-waves in London and combined fluvial and pluvial floods in Northumberland and Cumbria. The authors examine the data and indicators of past events in order to assess current situations and to tackle the dynamics of community resilience. In addition, they put the focus on empirical analysis to explore the resilience concept and to test the usage of indicators for describing community resilience. This important text: * Merges the forces of research knowledge, networking and practices in order to understand community disaster resilience * Contains the results of the acclaimed project Building Resilience Amongst Communities in Europe - emBRACE * Explores the key dimensions of community resilience * Includes five illustrative case studies from European communities that face various hazards Written for undergraduate students, postgraduates and researchers of social science, and policymakers, Framing Community Disaster Resilience reports on the findings of an important study to reveal the most effective approaches to enhancing community resilience. The emBRACE research received funding from the European Community's Seventh Framework Programme FP7/200
- Published
- 2018
10. The emBRACE resilience framework : developing an integrated framework for evaluating community resilience to natural hazards
- Author
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Deeming, H., Fordham, M., Kuhlicke, C., Pedoth, L., Schneiderbauer, S., Shreve, C., Kruse, S., Abeling, T., Forrester, J., Jülich, S., Karanci, A.N., Kuhlicke, Christian, Pelling, M., Sharpe, J., Deeming, H., Fordham, M., Kuhlicke, C., Pedoth, L., Schneiderbauer, S., Shreve, C., Kruse, S., Abeling, T., Forrester, J., Jülich, S., Karanci, A.N., Kuhlicke, Christian, Pelling, M., and Sharpe, J.
- Abstract
Community resilience has become an important concept for characterising and measuring the abilities of populations to anticipate, absorb, accommodate, and recover from the effects of a hazardous event in a timely and efficient manner. Many conceptual and empirical studies have shown that communities are an important scale and setting for building resilience that can enhance both individual/household and wider population‐level outcomes. The literature reviews at the early stages of the project aimed at providing a point of reference for the development of the emBRACE resilience framework. The emBRACE resilience framework conceptualises community resilience as a set of intertwined components in a three‐layer framework. The proposed three‐layered and tripartite framework for characterising community resilience is developed deductively by considering theoretical approaches of resilience from various disciplinary backgrounds and state of the art research. The result is a theory‐ informed heuristic that guides empirical research as well as practical disaster management and community development.
- Published
- 2018
11. Removal Of Impacted Rectal Foreign Body
- Author
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Fordham, M. W.
- Published
- 1976
12. Use Of Obstetric Forceps
- Author
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Chalmers, J. A., Redman, T. F., and Fordham, M. W.
- Published
- 1953
13. Global Gender and Environment Outlook: The Critical Issues
- Author
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Bechtel, J., Bock, S., Dankelman, I.E.M., and Fordham, M.
- Subjects
Philosophy and Science Studies - Abstract
Contains fulltext : 176246.pdf (Publisher’s version ) (Open Access) Summary report (published) of the E-book of UNEP: Global Gender and Environment Outlook (2016) 89 p.
- Published
- 2016
14. Conceptualizing community resilience to natural hazards – the emBRACE framework
- Author
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Kruse, S., Abeling, T., Deeming, H., Fordham, M., Forrester, J., Jülich, S., Karanci, A.N., Kuhlicke, Christian, Pelling, M., Pedoth, Lydia, Schneiderbauer, S., Kruse, S., Abeling, T., Deeming, H., Fordham, M., Forrester, J., Jülich, S., Karanci, A.N., Kuhlicke, Christian, Pelling, M., Pedoth, Lydia, and Schneiderbauer, S.
- Abstract
The level of community is considered to be vital for building disaster resilience. Yet, community resilience as a scientific concept often remains vaguely defined and lacks the guiding characteristics necessary for analysing and enhancing resilience on the ground. The emBRACE framework of community resilience presented in this paper provides a heuristic analytical tool for understanding, explaining and measuring community resilience to natural hazards. It was developed in an iterative process building on existing scholarly debates, on empirical case study work in five countries and on participatory consultation with community stakeholders where the framework was applied and ground-tested in different contexts and for different hazard types. The framework conceptualizes resilience across three core domains: (i) resources and capacities, (ii) actions and (iii) learning. These three domains are conceptualized as intrinsically conjoined within a whole. Community resilience is influenced by these integral elements as well as by extra-community forces comprising disaster risk governance and thus laws, policies and responsibilities on the one hand and on the other, the general societal context, natural and human-made disturbances and system change over time. The framework is a graphically rendered heuristic, which through application can assist in guiding the assessment of community resilience in a systematic way and identifying key drivers and barriers of resilience that affect any particular hazard-exposed community.
- Published
- 2017
15. Operationalizing risk perception and preparedness behavior research for a multi-hazard context
- Author
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Shreve, C., Begg, Chloe, Fordham, M., Müller, Annemarie, Shreve, C., Begg, Chloe, Fordham, M., and Müller, Annemarie
- Abstract
Increasingly, citizens are being asked to take a more active role in disaster risk reduction (DRR), as decentralization of hazard governance has shifted greater responsibility for hazard preparedness actions onto individuals. Simultaneously, the taxonomy of hazards considered for DRR has expanded to include medical and social crises alongside natural hazards. Risk perception research emerged to support decision-makers with understanding how people characterize and evaluate different hazards to anticipate behavioral response and guide risk communication. Since its inception, the risk perception concept has been incorporated into many behavioral theories, which have been applied to examine preparedness for numerous hazard types. Behavioral theories have had moderate success in predicting or explaining preparedness behaviors; however, they are typically applied to a single hazard type and there is a gap in understanding which theories (if any) are suited for examining multiple hazard types simultaneously. This paper first reviews meta-analyses of behavioral theories to better understand performance. Universal lessons learnt are summarized for survey design. Second, theoretically based preparedness studies for floods, earthquakes, epidemics, and terrorism are reviewed to assess the conceptual requirements for a ‘multi-hazard’ preparedness approach. The development of an online preparedness self-assessment and learning platform is discussed.
- Published
- 2016
16. Immediate versus deferred treatment for advanced prostatic cancer: initial results of the Medical Research Council trial
- Author
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Adib, RS, Anderson, JB, Ashken, MH, Baumber, CD, Bevis, CRA, Beynon, LL, Blaxland, JW, Boag, V, Bolger, JJ, Boreham, J, Bramble, FJ, Breakey, J, Bullock, KN, Burrett, J, Carswell, GF, Charlton, CAC, Chilton, CP, Chisholm, GD, Clack, R, Claridge, M, Clark, PB, Coulton, ER, Cox, SR, Cresswell, SM, Crowther, J, Davies, M, DeSousa, BA, Deane, RF, Devereux, MH, Doyle, PT, English, P, Evans, CM, Fellows, GJ, Fernie, CGM, Fordham, M, French, ME, Gaches, CGC, Gallegos, CRR, Gilliland, EL, Glaholm, J, Glashan, RW, Grant, JBP, Grayson, CEA, Green, NA, Griffin, S, Hall, RR, Hafner, B, Hargreave, TB, Harrison, GSM, Heal, MR, Hehir, M, Hetherington, J, James, MJ, Jones, PA, Jones, RA, Jurczyk, LN, Kirk, D, Knight, S, Lawrence, WT, Logie, JRC, Lucas, M, Luck, RJ, McGregor, A, McKelvie, GB, Moffat, LEF, Moore, KTH, Morgan, RJ, Newling, DWK, Orr, PGG, Parish, S, Perry, K, Peto, R, Pollard, R, Powell, CS, Radley, A, Rampling, R, Rennie, CD, Rhind, JR, Richards, B, Roberts, C, Robinson, MRG, Rogers, ACN, Rose, MB, Ross, RTA, Royle, MG, Sagar, S, Sethia, KK, Shearer, RJ, Shepheard, BGF, Smith, J, Smith, JC, Smith, MF, Smith, PH, Sole, GM, Stephenson, TP, Stewart, AL, Stower, MJ, Styles, RA, Thomson, RW, Thompson, E, Tolley, DA, Townell, NH, Turner, DTL, Urwin, GH, Ward, JP, Watson, GS, Watson, GM, Wightman, JAK, and Williams, JL
- Subjects
Oncology ,medicine.medical_specialty ,Prostate cancer ,Deferred treatment ,business.industry ,Urology ,Internal medicine ,medicine ,Cancer metastasis ,Cancer ,medicine.disease ,Medical research ,business - Published
- 1997
- Full Text
- View/download PDF
17. Determinants of risk: Exposure and vulnerability
- Author
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Field, CB, Barros, V, Stocker, TF, Cardona, O.D., van Aalst, M.K., Birkmann, J., Fordham, M., McGregor, G., Mechler, R., Field, CB, Barros, V, Stocker, TF, Cardona, O.D., van Aalst, M.K., Birkmann, J., Fordham, M., McGregor, G., and Mechler, R.
- Abstract
Many climate change adaptation efforts aim to address the implications of potential changes in the frequency, intensity, and duration of weather and climate events that affect the risk of extreme impacts on human society. That risk is determined not only by the climate and weather events (the hazards) but also by the exposure and vulnerability to these hazards. Therefore, effective adaptation and disaster risk management strategies and practices also depend on a rigorous understanding of the dimensions of exposure and vulnerability, as well as a proper assessment of changes in those dimensions. This chapter aims to provide that understanding and assessment, by further detailing the determinants of risk as presented in Chapter 1. The first sections of this chapter elucidate the concepts that are needed to define and understand risk, and show that risk originates from a combination of social processes and their interaction with the environment (Sections 2.2 and 2.3), and highlight the role of coping and adaptive capacities (Section 2.4). The following section (2.5) describes the different dimensions of vulnerability and exposure as well as trends therein. Given that exposure and vulnerability are highly context-specific, this section is by definition limited to a general overview (a more quantitative perspective on trends is provided in Chapter 4). A methodological discussion (Section 2.6) of approaches to identify and assess risk provides indications of how the dimensions of exposure and vulnerability can be explored in specific contexts, such as adaptation planning, and the central role of risk perception and risk communication. The chapter concludes with a cross-cutting discussion of risk accumulation and the nature of disasters.
- Published
- 2012
18. Long-term responses of the green-algal lichen Parmelia caperata to natural CO2 enrichment
- Author
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Balaguer, Luis, Manrique, Esteban, Ríos, Asunción de los, Ascaso, Carmen, Palmqvist, K., Fordham, M., and Barnes, J.D.
- Subjects
Rubisco ,Photosynthetic performance ,Elevated CO2 ,Photobiont ultrastructure ,Lichenized green algae - Abstract
8 pages, figures, and tables statistcs., Acclimation to elevated CO2 was investigated in Parmelia caperata originating from the vicinity of a natural CO2 spring, where the average daytime CO2 concentration was 729 39 lmol mol)1 dry air. Thalli showed no evidence of a down-regulation in photosyn- thetic capacity following long-term exposure to CO2 enrichment in the ®eld; carboxylation e ciency, total Ribulose bisphosphate carboxylase/oxygenase (Rubisco) content, apparent quantum yield of CO2 assimilation, and the light-saturated rate of CO2 assimilation (measured under ambient and saturating CO2 concen- trations) were similar in thalli from the naturally CO2 enriched site and an adjacent control site where the average long-term CO2 concentration was about 355 lmol mol)1. Thalli from both CO2 environments exhibited low CO2 compensation points and early sat- uration of CO2 uptake kinetics in response to increasing external CO2 concentrations, suggesting the presence of an active carbon-concentrating mechanism. Consistent with the lack of signi®cant e ects on photosynthetic metabolism, no changes were found in the nitrogen content of thalli following prolonged exposure to elevated CO2. Detailed intrathalline analysis revealed a decreased investment of nitrogen in Rubisco in the pyrenoid of algae located in the elongation zone of thalli originating from elevated CO2, an e ect associated with a reduction in the percentage of the cell volume occupied by lipid bodies and starch grains. Although these dif- ferences did not a ect the photosynthetic capacity of thalli, there was evidence of enhanced limitations to CO2 assimilation in lichens originating from the CO2-en- riched site. The light-saturated rate of CO2 assimilation measured at the average growth CO2 concentration was found to be signi®cantly lower in thalli originating from a CO2-enriched atmosphere compared with that of thalli originating and measured at ambient CO2. At lower photosynthetic photon ¯ux densities, the light com- pensation point of net CO2 assimilation was signi®- cantly higher in thalli originating from elevated CO2, and this e ect was associated with higher usnic acid content.
- Published
- 1999
19. The detrimental impact of high pulp temperature on sphalerite flotation after zinc regrinding in the zinc plant of Somincor, Lundin Mining Corporation, Neves Corvo, Portugal.
- Author
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He S., MetPlant 2008: metallurgical plant design and operating strategies Perth, Western Australia 18-Aug-0819-Aug-08, Curral J., Fordham M., Grano S., Manouchehri H., He S., MetPlant 2008: metallurgical plant design and operating strategies Perth, Western Australia 18-Aug-0819-Aug-08, Curral J., Fordham M., Grano S., and Manouchehri H.
- Abstract
The Zn rougher concentrate is reground with forged steel media before flotation with one stage of roughing and scavenging and three stages of cleaning to obtain a final concentrate grading more than 50% Zn. After regrinding sphalerite flotation was seriously affected by the high pulp temperature which may occur during the summer months. Mineral recoveries were significantly reduced at pulp temperatures above 60 degrees C and elevated CuSO4 concentrations or reduced pH alone did not result in an appreciable increase in Zn recovery. However, a combination of these two, such as a decrease in pH from 11.5 to 10.8 and an increase in CuSO4 dosage from 400 to 800 g/t, reduced Zn depression at high pulp temperature. At pulp temperatures below 45 degrees C the negative effect of pulp temperature on recoveries was minimal. Flotation tests and solution/surface analyses were carried out to study the causes for poor sphalerite flotation at high pulp temperature after regrinding. The results showed that the decrease in recovery was associated with variations in the surface species on the mineral particles in response to the increased pulp temperature, including collector desorption and superficial oxidation to form Pb/Zn oxide/hydroxides on the particles., The Zn rougher concentrate is reground with forged steel media before flotation with one stage of roughing and scavenging and three stages of cleaning to obtain a final concentrate grading more than 50% Zn. After regrinding sphalerite flotation was seriously affected by the high pulp temperature which may occur during the summer months. Mineral recoveries were significantly reduced at pulp temperatures above 60 degrees C and elevated CuSO4 concentrations or reduced pH alone did not result in an appreciable increase in Zn recovery. However, a combination of these two, such as a decrease in pH from 11.5 to 10.8 and an increase in CuSO4 dosage from 400 to 800 g/t, reduced Zn depression at high pulp temperature. At pulp temperatures below 45 degrees C the negative effect of pulp temperature on recoveries was minimal. Flotation tests and solution/surface analyses were carried out to study the causes for poor sphalerite flotation at high pulp temperature after regrinding. The results showed that the decrease in recovery was associated with variations in the surface species on the mineral particles in response to the increased pulp temperature, including collector desorption and superficial oxidation to form Pb/Zn oxide/hydroxides on the particles.
- Published
- 2008
20. Naturally occurring polymorphisms in HIV-1 integrase: Relationship to HIV subtype, integrase inhibitor resistance and immune selection
- Author
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Tschochner, M., Chopra, A., Ahmad, I., Fordham, M., Mallal, S., John, M., Tschochner, M., Chopra, A., Ahmad, I., Fordham, M., Mallal, S., and John, M.
- Abstract
See Attached
- Published
- 2008
21. Flood hazard assessment, modelling and management: Results from the EUROFLOOD project
- Author
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PENNING ROWSELL, E, Fordham, M, Correia, F, Green, C, Hubert, G, Ketteridge, A. M., Klaus, J, Parker, D, Peerbolte, B, Pflugner, W, Rejtano, Bartolomeo, Rocha, J, SANCHEZ ARCILLA, A, Saraiva, M. G., Schmidtke, R, Torterotot, J. P., VAN DER VEEN, A, Wierstra, E, and Wind, H.
- Subjects
METIS-125012 - Published
- 1995
22. A rapid and cost-effective method for bench screening of geochemical performance and disposal options for high-sulphide tailings.
- Author
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Verburg R., 6th ICARD International conference on acid rock drainage Cairns, Queensland 14-Jul-0314-Jul-03, Fordham M., Johnson B., Logsdon M., Verburg R., 6th ICARD International conference on acid rock drainage Cairns, Queensland 14-Jul-0314-Jul-03, Fordham M., Johnson B., and Logsdon M.
- Abstract
The underground Neves Corvo Cu-Sn mine, Portugal, currently uses a conventional wet tailings impoundment. An evaluation was carried out of 24 tailings disposal alternatives using a cost-effective and easily implemented bench-scale geochemical screening programme conducted on site. The tailings are pyrite-rich and highly acid-generating, and particular emphasis was placed on monitoring likely indicators of sulphide oxidation under the various simulated disposal scenarios. Dependent parameters investigated included moisture content, use of alkaline additives (lime, cement), use of a bactericide and agitation. Response parameters included paste pH, specific conductivity and temperature as indicators of oxidation. The results indicate that a number of relationships exist between the geochemical stability of the samples (sulphide oxidation) and their characteristics. A limited number of tailings mixtures were selected for further long-term testing in field weathering cells to aid in the identification of the optimal mix design for future tailings disposal., The underground Neves Corvo Cu-Sn mine, Portugal, currently uses a conventional wet tailings impoundment. An evaluation was carried out of 24 tailings disposal alternatives using a cost-effective and easily implemented bench-scale geochemical screening programme conducted on site. The tailings are pyrite-rich and highly acid-generating, and particular emphasis was placed on monitoring likely indicators of sulphide oxidation under the various simulated disposal scenarios. Dependent parameters investigated included moisture content, use of alkaline additives (lime, cement), use of a bactericide and agitation. Response parameters included paste pH, specific conductivity and temperature as indicators of oxidation. The results indicate that a number of relationships exist between the geochemical stability of the samples (sulphide oxidation) and their characteristics. A limited number of tailings mixtures were selected for further long-term testing in field weathering cells to aid in the identification of the optimal mix design for future tailings disposal.
- Published
- 2003
23. Combined analysis of Two-Year Follow-up from two open-label randomized trials comparing efficacy of three nucleoside reverse transcriptase inhibitor backbones for previously untreated HIV-1 nfection: OzCombo 1 and 2
- Author
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Amin, J., Moore, A., Carr, A., French, M.A., Law, M., Emery, S., Cooper, D.A., Kotsiou, G., Norrito, L., Dwyer, D., Packham, D., Fordham, M., Garsia, R., Baker, D., Doong, N.C., Quan, D., Beveridge, A., Genn, W., Quin, J., Mulholland, J., Sowden, D., Rawlinsen, M., Rebic, D., Street, A., De Graaf, B., Roney, J., Bryant, M., McCormack, C., Hoy, J.N., Shaw, D.V., Ferguson, W., Waddell, R., Papanaoum, K., French, M.R., Scull, N., Todhunter, L., Mallal, S., James, R., Foreman, E., Amin, J., Moore, A., Carr, A., French, M.A., Law, M., Emery, S., Cooper, D.A., Kotsiou, G., Norrito, L., Dwyer, D., Packham, D., Fordham, M., Garsia, R., Baker, D., Doong, N.C., Quan, D., Beveridge, A., Genn, W., Quin, J., Mulholland, J., Sowden, D., Rawlinsen, M., Rebic, D., Street, A., De Graaf, B., Roney, J., Bryant, M., McCormack, C., Hoy, J.N., Shaw, D.V., Ferguson, W., Waddell, R., Papanaoum, K., French, M.R., Scull, N., Todhunter, L., Mallal, S., James, R., and Foreman, E.
- Abstract
Purpose: To compare inhibition of HIV replication, improvements in CD4+ T-cell counts, metabolic parameters, and body shape changes after 2 years of assigned therapy in OzCombo patients. Method: Study participants were those who were recruited into the open-label OzCombo 1 (1996/1997) and OzCombo 2 (1997/1998) trials. Patients in OzCombo 1 were randomized to receive indinavir in combination with zidovudine+lamivudine (AZT+3TC; n = 35), stavudine (d4T)+3TC (n = 34), or d4T+didanosine (ddI) (n = 37). OzCombo 2 patients were randomized to the same nucleoside reverse transcriptase inhibitor (NRTI) backbones with nevirapine (n = 20, 22, 23, respectively). The mean time-weighted changes from baseline in CD4 T-cell count/mL, HIV RNA (log copies/mL plasma), and proportions with detectable viral load (<500 copies plasma HIV RNA/mL) between NRTI arms over 2 years were compared by formal meta-analysis. A cross-sectional study of metabolic and body shape complications was also undertaken. Results: For the comparison of d4T+3TC and d4T+ddI to AZT+3TC, mean differences in time-weighted change from baseline in CD4 T-cell count/wL and log copies HIV RNA/mL adjusted for baseline CD4+ T-cell and HIV RNA counts were: m44 (p = .08) and m14 (p = .56) cells/wL and m0.1 (p = .40) and m0.1 (p = .6) copies/mL. Odds ratios for detectable viral load in the last study quarter were 0.6 (p = .44) and 1.0 (p = .95). The mean percent leg fat was lower in the d4T+3TC and d4T+ddI than the AZT+3TC arm (mean difference 5.1% [p = .07] and 7.6% [p = .02], respectively). Conclusion: For all regimens, virological control and immunological response were maintained over 2 years. Regimens containing d4T and particularly d4T+ddI were significantly associated with increased peripheral fat loss compared with AZT+3TC.
- Published
- 2003
24. evaluation of flood forecasting, warning and response systems in the European Union
- Author
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Parker, D., Fordham, M., Parker, D., and Fordham, M.
- Published
- 1996
25. Decline in stomatal response to leaf water deficit in Corylus maxima cuttings
- Author
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Fordham, M. C., primary, Harrison-Murray, R. S., additional, Knight, L., additional, and Clay, C. M., additional
- Published
- 2001
- Full Text
- View/download PDF
26. Long-term responses of the green-algal lichen Parmelia caperata to natural CO 2 enrichment
- Author
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Balaguer, L., primary, Manrique, E., additional, de los Rios, A., additional, Ascaso, C., additional, Palmqvist, K., additional, Fordham, M., additional, and Barnes, J. D., additional
- Published
- 1999
- Full Text
- View/download PDF
27. The impact of elevated CO 2 on growth and photosynthesis in Agrostis canina L. ssp. monteluccii adapted to contrasting atmospheric CO 2 concentrations
- Author
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Barnes, J. D., primary, Bettarini, I., additional, Polle, A., additional, Slee, N., additional, Raines, C., additional, Miglietta, F., additional, Raschi, A., additional, and Fordham, M., additional
- Published
- 1997
- Full Text
- View/download PDF
28. Carbon-Isotope Composition of Biochemical Fractions and the Regulation of Carbon Balance in Leaves of the C3-Crassulacean Acid Metabolism Intermediate Clusia minor L. Growing in Trinidad
- Author
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Borland, A. M., primary, Griffiths, H., additional, Broadmeadow, MSJ., additional, Fordham, M. C., additional, and Maxwell, C., additional
- Published
- 1994
- Full Text
- View/download PDF
29. Long-term responses of the green-algal lichen Parmelia caperata to natural CO2 enrichment.
- Author
-
Balaguer, L., Manrique, E., de los Rios, A., Ascaso, C., Palmqvist, K., Fordham, M., and Barnes, J. D.
- Abstract
Acclimation to elevated CO
2 was investigated in Parmelia caperata originating from the vicinity of a natural CO2 spring, where the average daytime CO2 concentration was 729 ± 39 μmol mol−1 dry air. Thalli showed no evidence of a down-regulation in photosynthetic capacity following long-term exposure to CO2 enrichment in the field; carboxylation efficiency, total Ribulose bisphosphate carboxylase/oxygenase (Rubisco) content, apparent quantum yield of CO2 assimilation, and the light-saturated rate of CO2 assimilation (measured under ambient and saturating CO2 concentrations) were similar in thalli from the naturally CO2 enriched site and an adjacent control site where the average long-term CO2 concentration was about 355 μmol mol−1 . Thalli from both CO2 environments exhibited low CO2 compensation points and early saturation of CO2 uptake kinetics in response to increasing external CO2 concentrations, suggesting the presence of an active carbon-concentrating mechanism. Consistent with the lack of significant effects on photosynthetic metabolism, no changes were found in the nitrogen content of thalli following prolonged exposure to elevated CO2 . Detailed intrathalline analysis revealed a decreased investment of nitrogen in Rubisco in the pyrenoid of algae located in the elongation zone of thalli originating from elevated CO2 , an effect associated with a reduction in the percentage of the cell volume occupied by lipid bodies and starch grains. Although these differences did not affect the photosynthetic capacity of thalli, there was evidence of enhanced limitations to CO2 assimilation in lichens originating from the CO2 -enriched site. The light-saturated rate of CO2 assimilation measured at the average growth CO2 concentration was found to be significantly lower in thalli originating from a CO2 -enriched atmosphere compared with that of thalli originating and measured at ambient CO2 . At lower photosynthetic photon flux densities, the light compensation point of net CO2 assimilation was significantly higher in thalli originating from elevated CO2 , and this effect was associated with higher usnic acid content. [ABSTRACT FROM AUTHOR]- Published
- 1999
- Full Text
- View/download PDF
30. The impact of elevated CO2 on growth and photosynthesis in Agrostis canina L. ssp. monteluccii adapted to contrasting atmospheric CO2 concentrations.
- Author
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Barnes, J. D., Bettarini, I., Polle, A., Slee, N., Raines, C., Miglietta, F., Raschi, A., and Fordham, M.
- Abstract
The aim of this study was to characterise growth and photosynthetic capacity in plants adapted to long-term contrasting atmospheric CO
2 concentrations ( Ca ). Seeds of Agrostis canina L. ssp. monteluccii were collected from a natural CO2 transect in central-western Italy and plants grown in controlled environment chambers at both ambient and elevated CO2 (350 and 700 μmol mol−1 ) in nutrient-rich soil. Seasonal mean Ca at the source of the plant material ranged from 610 to 451 μmol CO2 mol−1 , derived from C4 leaf stable carbon isotope discrimination (δ13 C). Under chamber conditions, CO2 enrichment stimulated the growth of all populations. However, plants originating from elevated Ca exhibited higher initial relative growth rates (RGRs) irrespective of chamber CO2 concentrations and a positive relationship was found between RGR and Ca at the seed source. Seed weight was positively correlated with Ca , but differences in seed weight were found to explain no more than 34% of the variation in RGRs at elevated CO2 . Longer-term experiments (over 98 days) on two populations originating from the extremes of the transect (451 and 610 μmol CO2 mol−1 ) indicated that differences in growth between populations were maintained when plants were grown at both 350 and 700 μmol CO2 mol−1 . Analysis of leaf material revealed an increase in the cell wall fraction (CWF) in plants grown at elevated CO2 , with plants originating from high Ca exhibiting constitutively lower levels but a variable response in terms of the degree of lignification. In vivo gas exchange measurements revealed no significant differences in light and CO2 saturated rates of photosynthesis and carboxylation efficiency between populations or with CO2 treatment. Moreover, SDS-PAGE/ LISA quantification of leaf ribulose bisphosphate carboxylase/oxygenase (Rubisco) showed no difference in Rubisco content between populations or CO2 treatments. These findings suggest that long-term adaptation to growth at elevated CO2 may be associated with a potential for increased growth, but this does not appear to be linked with differences in the intrinsic capacity for photosynthesis. [ABSTRACT FROM AUTHOR]- Published
- 1997
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31. Short-term changes in carbon-isotope discrimination in the C3-CAM intermediate Clusia minor L. growing in Trinidad
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Borland, A. M., Griffiths, H., Broadmeadow, M. S. J., Fordham, M. C., and Maxwell, C.
- Abstract
On-line instantaneous carbon isotope discrimination was measured in conjunction with net uptake of CO
2 in leaves of exposed and shaded plants of the C3 -CAM intermediate Clusia minor growing under natural conditions in Trinidad. At the end of the rainy season (late January-early February, 1992) C3 photosynthesis predominated although exposed leaves recaptured a small proportion of respiratory CO2 at night for the synthesis of malic acid. Citric acid was the major organic acid accumulated by exposed leaves at this time with a citric: malic acid ratio of 11:1. Values of instantaneous discrimination (?) in exposed leaves during the wet season rose from 17.1‰ shortly after dawn to 22.7‰ around mid-day just before stomata closed, suggesting that most CO2 was fixed by Rubisco at this time. During the late afternoon, instantaneous ? declined from 22.2‰ to 17‰, probably reflecting the limited contribution from PEPc activity and an increase in diffusional resistance to CO2 in exposed leaves. Shaded leaves showed no CAM activity and CO2 uptake proceeded throughout the day in the wet season. The decrease in instantaneous ? from 27‰ in the morning to 19.2‰ in the late afternoon was therefore entirely due to diffusional limitation. Leaves sampled in the dry season (mid-March, 1992) had by now induced full CAM activity with both malic and citric acids accumulated overnight and stomata closed for 4–5 h over the middle of the day. Values of instantaneous ? measured over the first 3 h after dawn (6.4–9.1‰) indicated that C4 carboxylation dominated CO2 uptake for most of the morning when rates of photosynthesis were maximal, implying that under natural conditions, the down regulation of PEPc in phase II occurs much more slowly than laboratory-based studies have suggested. The contribution from C3 carboxylation to CO2 uptake during phase II was most marked in leaves which accumulated lower quantities of organic acids overnight. In exposed leaves, measurements of instantaneous ? during the late afternoon illustrated the transition from C3 to C4 carboxylation with stomata remaining open during the transition from dusk into the dark period. Uptake of CO2 by shaded leaves during the late afternoon however appeared to be predominantly limited by decreased stomatal conductance. The short-term measurements of instantaneous ? were subsequently integrated over 24 h in order to predict the leaf carbon isotope ratios (dp ) and to compare this with the dp measured for leaf organic material. Whilst there was close agreement between predicted and measured dp for plants sampled in the wet season, during the dry season the predicted carbon isotope ratios were 5–9‰ higher than the measured isotope ratios. During the annual cycle of leaf growth most carbon was fixed via the C3 pathway although CAM clearly plays an important role in maintaining photochemical integrity in the dry season.- Published
- 1993
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32. Use of confocal imaging in the study of biological structures
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Amos, W. B., White, J. G., and Fordham, M.
- Abstract
Scanning confocal microscopy offers several potential advantages for light microscope studies of biological material. Foremost amongst these is the rejection of interfering signals from out-of-focus structures, which often seriously degrade images. The degradation in image quality with epifluorescence microscopy is particularly pronounced; an unfortunate situation, as this is one of the most commonly used techniques in biological research. Confocal imaging almost completely eliminates this problem and therefore promises to have a wide application in this area. We have developed a high-speed beam scanning confocal imaging system that can be used in conjunction with a conventional microscope, and have examined a variety of biological material using this system. In all cases we have found that confocal imaging gives a marked improvement in quality over conventional techniques. The improvement is particularly spectacular with thick specimens viewed with epifluorescence.
- Published
- 1987
33. The feasibility and cost of a large multicentre audit of process and outcome of prostatectomy.
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Emberton, M, Neal, D E, Black, N, Harrison, M, Fordham, M, McBrien, M P, Williams, R E, McPherson, K, and Develin, H B
- Abstract
Objective--To determine the feasibility of performing multicentre process and outcome audits of common interventions taking prostatic procedures as an example. Design--Prospective, cohort study. Setting--All National Health Service and independent hospitals in Northern, Wessex, Mersey, and South West Thames health regions. Patients--5361 men undergoing prostatectomy identified by 103 of the 107 urologists and general surgeons performing prostatectomy in the study regions. Main measures-- Rates of participation by surgeons and patients; completeness of clinical data provided by surgeons; patient response rate and completeness of patient derived data; and cost. Results--Most surgeons (103,96%) agreed to participate. Overall, the proportion of eligible patients invited to take part was high (89%), although this was only measured in South West Thames, where dedicated data collectors were employed. Few men (80, 1.5%) declined to participate. Of those surviving for three months after surgery, 82.4% (4226) completed and returned the postal questionnaire. The response rate was higher in South West Thames (86.7%) than in the other regions (80.6%-80.8%). The audit was well received: 91% of patients found the questionnaire easy to complete and only 2.3% of them disapproved. Completeness of data was high with both the hospital and patient questionnaires. Missing data occurred in less than 5% of responses to most questions. The attributable cost was 34.50 pounds per patient identified or 44 pounds for patients in whom either the treatment outcome or vital status was known three months after their prostatectomy. Conclusions--This multicentre audit of process and outcome of prostatectomy proved feasible in terms of surgeon participation, patient identification, and the quantity and quality of data collection. Whether the cost was warranted will depend on how surgeons use the audit data to modify their practice.
- Published
- 1995
34. LII.— Some new Asilidæ from Western Australia
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Dakin, William J. and Fordham, M. G. G.
- Abstract
n/a
- Published
- 1922
35. Herpetological observations from field expeditions to North Karnataka and Southwest Maharashtra, India
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Todd Lewis, Piggott, S., Griffin, R., Greig-Smith, P., Martins, G., Barretto, G., Bajibab, K., Thorpe-Dixon, J., Prodromou, P., Fordham, M., Willis, D., Turner, J., Radovanovic, A., Holloway, D., Wood, R., Hand, N., Lloyd, S., Clapson, M., Hennesy, J., and Oldham, G.
- Subjects
Herpetofauna, reptile, amphibian, population, conservation, Western Ghats, India - Abstract
The Western Ghats of India are one of the 34 global hotspots of biodiversity. They are one of the most important large natural areas in the world and are fast becoming recognised for their biological importance. The herpetofauna of the Western Ghats is hugely diverse, with many species exhibiting rare, endemic styles of autecology and niche preference that could equal that of countries such as Borneo and Madagascar. In this report we detail 18 amphibian and 37 reptile species from eight sites following three expeditions to the Western Ghats from 2007-2009. The report details species descriptions, habitat, ecology and conservation to alert the herpetological community to the importance of future research to address the lack of knowledge in species ecology. It also presents newinformation on species distribution and behaviour.
36. Removal of deleterious elements from copper sulphide concentrate.
- Author
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Mielczarski J.A., Barres O., Bouquet E., Cases J., de Donato P., Fordham M., Kongolo M., Marion P., Mielczarski E., Valente C., Mielczarski J.A., Barres O., Bouquet E., Cases J., de Donato P., Fordham M., Kongolo M., Marion P., Mielczarski E., and Valente C.
- Abstract
Successful separation of unwanted elements in production of base metal concentrates depends heavily on the determination of the relationships between the occurrence of the minor components and their carriers, and of the mechanisms of surface interactions between these carrier minerals and reagent solutions. Surface and bulk characterisation of mineral samples was performed using IR reflectance methods, X-ray photoelectron spectroscopy, and electron microprobe techniques. Pure and industrial samples of chalcopyrite, pyrite, sphalerite and galena were used, with adsorption of amyl xanthate. Flotation was carried out in a laboratory cell and at industrial scale. Selected results of the mineral surface characterisations are presented relevant to selective flotation. Using the results, modifications were tested on industrial-scale circuits for the flotation of chalcopyrite: thickener bypassing and increase in reducing conditions in the conditioning part of the circuit. A reduction in antimony recovery from 22% to 12% was achieved., Successful separation of unwanted elements in production of base metal concentrates depends heavily on the determination of the relationships between the occurrence of the minor components and their carriers, and of the mechanisms of surface interactions between these carrier minerals and reagent solutions. Surface and bulk characterisation of mineral samples was performed using IR reflectance methods, X-ray photoelectron spectroscopy, and electron microprobe techniques. Pure and industrial samples of chalcopyrite, pyrite, sphalerite and galena were used, with adsorption of amyl xanthate. Flotation was carried out in a laboratory cell and at industrial scale. Selected results of the mineral surface characterisations are presented relevant to selective flotation. Using the results, modifications were tested on industrial-scale circuits for the flotation of chalcopyrite: thickener bypassing and increase in reducing conditions in the conditioning part of the circuit. A reduction in antimony recovery from 22% to 12% was achieved.
37. Global gender and environment outlook
- Author
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Seager, J., Bechtel, J., Bock, S., Dankelman, I., Fordham, M., Gabizon, S., Thuy Trang, N., Perch, L., Qayum, S., Roehr, U., Schoolmeester, T., Steinbach, R., Watts, M., Wendland, C., Aguilar, L., Álvarez, I., Araújo, K., Basnett, B.S., Bauer, J., Bowser, G., Caterbow, A., Corendea, C., Donners, A., Dutta, S., Halle, S., halainen, M., Ismawati, Y., Joshi, D., Kiwala, L., Kolbeinsdottir, L., Koppen, Barbara C.M. van, Seager, J., Bechtel, J., Bock, S., Dankelman, I., Fordham, M., Gabizon, S., Thuy Trang, N., Perch, L., Qayum, S., Roehr, U., Schoolmeester, T., Steinbach, R., Watts, M., Wendland, C., Aguilar, L., Álvarez, I., Araújo, K., Basnett, B.S., Bauer, J., Bowser, G., Caterbow, A., Corendea, C., Donners, A., Dutta, S., Halle, S., halainen, M., Ismawati, Y., Joshi, D., Kiwala, L., Kolbeinsdottir, L., and Koppen, Barbara C.M. van
38. Global gender and environment outlook
- Author
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Seager, J., Bechtel, J., Bock, S., Dankelman, I., Fordham, M., Gabizon, S., Thuy Trang, N., Perch, L., Qayum, S., Roehr, U., Schoolmeester, T., Steinbach, R., Watts, M., Wendland, C., Aguilar, L., Álvarez, I., Araújo, K., Basnett, B.S., Bauer, J., Bowser, G., Caterbow, A., Corendea, C., Donners, A., Dutta, S., Halle, S., halainen, M., Ismawati, Y., Joshi, D., Kiwala, L., Kolbeinsdottir, L., Koppen, Barbara C.M. van, Seager, J., Bechtel, J., Bock, S., Dankelman, I., Fordham, M., Gabizon, S., Thuy Trang, N., Perch, L., Qayum, S., Roehr, U., Schoolmeester, T., Steinbach, R., Watts, M., Wendland, C., Aguilar, L., Álvarez, I., Araújo, K., Basnett, B.S., Bauer, J., Bowser, G., Caterbow, A., Corendea, C., Donners, A., Dutta, S., Halle, S., halainen, M., Ismawati, Y., Joshi, D., Kiwala, L., Kolbeinsdottir, L., and Koppen, Barbara C.M. van
39. Transportation Finance: Kentucky's Structure and National Trends
- Author
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Hackbart, M., Perkins, S., Fordham, M., Hackbart, M., Perkins, S., and Fordham, M.
- Abstract
Studies state Road Fund tax structures, like studies of state General Funds, tend to focus on a state's current tax structure compared to surrounding states and identifying possible tax changes that may make a tax system simpler, more equitable, more administratively efficient, more competitive or more "adequate." In conducting such analysis. the inherent trade-offs among these accepted tax principles becomes apparent. Efforts to increase competitiveness may impact the adequacy of a tax system. Likewise, tax legislation intended to enhance tax administration efficiency may impact the equity of a state's Road Fund tax structure. Such tradde-offs associated with conflicting tax change or modernization goals has limited tax system changes ro reforms.
40. Birth of Peripatus in England
- Author
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DAKIN, WILLIAM J., primary and FORDHAM, M. G. C., additional
- Published
- 1926
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41. Surveillance of testicular microlithiasis?: Results of an UK based national questionnaire survey
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Cornford Philip A, Smith Richard, Ravichandran Subramanian, and Fordham Mark VP
- Subjects
Diseases of the genitourinary system. Urology ,RC870-923 - Abstract
Abstract Background The association of testicular microlithiasis with testicular tumour and the need for follow-up remain largely unclear. Methods We conducted a national questionnaire survey involving consultant BAUS members (BAUS is the official national organisation (like the AUA in USA) of the practising urologists in the UK and Ireland), to provide a snapshot of current attitudes towards investigation and surveillance of patients with testicular microlithiasis. Results Of the 464 questionnaires sent to the BAUS membership, 263(57%) were returned. 251 returns (12 were incomplete) were analysed, of whom 173(69%) do and 78(31%) do not follow-up testicular microlithiasis. Of the 173 who do follow-up, 119(69%) follow-up all patients while 54(31%) follow-up only a selected group of patients. 172 of 173 use ultra sound scan while 27(16%) check tumour makers. 10(6%) arrange ultrasound scan every six months, 151(88%) annually while 10(6%) at longer intervals. 66(38%) intend to follow-up these patients for life while, 80(47%) until 55 years of age and 26(15%) for up to 5 years. 173(68.9%) believe testicular microlithiasis is associated with CIS in < 1%, 53(21%) think it is between 1&10% while 7(3%) believe it is > 10%. 109(43%) believe those patients who develop a tumour, will have survival benefit with follow-up while 142(57%) do not. Interestingly, 66(38%) who follow-up these patients do not think there is a survival benefit. Conclusion There is significant variability in how patients with testicular microlithiasis are followed-up. However a majority of consultant urologists nationally, believe surveillance of this patient group confers no survival benefit. There is a clear need to clarify this issue in order to recommend a coherent surveillance policy.
- Published
- 2006
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42. Use of Obstetric Forceps.
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Fordham, M. W.
- Published
- 1953
43. Prognostic factors for survival in patients with advanced renal cell carcinoma treated with recombinant interleukin-2
- Author
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Palmer, P.A., Vinke, J., Philip, T., Negrier, S., Atzpodien, J., Kirchner, H., Oskam, R., Franks, C.R., Von der Maase, H., Thatcher, N., Jasmin, C., Fossa, S., Symann, M., Israel, L., Nagel, G., Stoter, G., Rugarli, C., Eremin, O., Iacone, A., Cleton, F., Janssens, J., Willems, Bergmann, L., West, W., Oldham, R., Dillman, R., Wiernik, P., Coltman, C., Raynor, A., Doroshow, J., Parkinson, D., Gallignoni, E., Guillou, P., Gore, M., Keen, C., Roberts, T., Harris, A., Fordham, M., Harper, P., Cornbleet, M., Selby, P., Hancock, B., Bleehan, N., Harland, S., Rowland, C., Ostrowski, M., Hamblin, T., Veitch, P., Sokal, M., Abrams, P., Oliver, R., Bodenstein, H., Czygan, P., de Mulder, P., and Wils, J.
- Published
- 1992
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44. Feasibility and assessment of a comprehensive emergency department-based intervention for patients at risk of HIV.
- Author
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Osman K, Rodgers J, Fordham M, Covington W, Hand DT, Ross-Davis K, and Walter LA
- Subjects
- Humans, Male, Female, Adult, Middle Aged, Prospective Studies, Cross-Sectional Studies, Risk Assessment methods, Risk Factors, Mass Screening methods, Alabama epidemiology, Young Adult, HIV Infections drug therapy, HIV Infections epidemiology, HIV Infections diagnosis, Emergency Service, Hospital, Feasibility Studies
- Abstract
Behavioral factors increase the risk of contracting HIV. A comprehensive prevention services (CPS) intervention includes risk assessment and referral for those with confirmed risk. This project sought to assess the feasibility of an emergency department (ED)-based CPS program. A prospective cross-sectional assessment was conducted from October, 2021 through May, 2023, at a single ED in Birmingham, Alabama. Either of two screening methods were subjected to HIV negative adults: 1) manual chief complaint review or 2) objective electronic medical record (EMR) query. Manual and EMR screening methods considered sexually transmitted infections (STIs) or a positive urine drug test (to observe for commonly injectable drugs) within 12 months of current ED visit. Identified patients were approached in the ED (manual review) or via phone (EMR alert). Persons confirmed at risk for HIV following engagement questionnaire completion were made aware of their risk and offered referral to local CPS clinics. Primary outcome was CPS linkage. Descriptive analysis was performed. Of 184 patients approached, 147 agreed to engagement (79.9%), 117 in-person and 30 via phone; 125 (85.1%) were confirmed at risk for HIV; majority were white (66.4%), male (63.2%), between the ages of 30 and 49 (64.8%), uninsured (78.4%), and without a primary care provider (93.6%). Sexual behavior was identified as a recent (within six months) risk factor in 97 (77.6%) patients. Injection drug use was identified as a recent (within six months) risk factor in 71 (56.8%) patients. Fifty-four (43.2%) expressed interest in obtaining CPS follow-up. To-date, ten patients (18.5%) have connected with a CPS counsellor via phone and five (9.3%) have had a subsequent follow-up appointment to discuss CPS with a medical provider. Thirty at-risk patients (24.0%) received ED-initiated buprenorphine/naloxone. Targeted screening tools can aid in the identification of persons at risk for HIV in the ED; further, subsequent engagement and CPS implementation amongst this cohort is feasible. CPS clinic linkage may be challenging however, a CPS definition inclusive of ED-initiated medication for opioid use disorder, may offer opportunity for increased uptake., Competing Interests: The commercial funder does not alter our adherence to all PLOS ONE policies on sharing data and materials., (Copyright: © 2024 Osman et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
- Published
- 2024
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45. The role of structured inpatient lipid protocols in optimizing non-statin lipid lowering therapy: a review and single-center experience.
- Author
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Gier C, Gilchrist I, Fordham M, Riordan L, Milchan E, Patel N, Mojahedi A, Choudhury S, Kits T, Cohen R, Doughtery J, Reilly JP, Kalogeropoulos A, Rahman T, and Chen O
- Abstract
Dyslipidemia is a leading contributor to atherosclerotic cardiovascular disease (ASCVD). There has been a significant improvement in the treatment of dyslipidemia in the past 10 years with the development of new pharmacotherapies. The intent of this review is help enhance clinicians understanding of non-statin lipid lowering therapies in accordance with the 2022 American College of Cardiology Expert Consensus Clinical Decision Pathway on the Role of Non-statin Therapies for LDL-Cholesterol Lowering. We also present a single-center experience implementing a systematic inpatient protocol for lipid lowering therapy for secondary prevention of ASCVD., Competing Interests: OC reports consulting/speaking fees from Amgen and Penumbra The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (© 2024 Gier, Gilchrist, Fordham, Riordan, Milchan, Patel, Mojahedi, Choudhury, Kits, Cohen, Doughtery, Reilly, Kalogeropoulos, Rahman and Chen.)
- Published
- 2024
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46. Commentary: The perspectives of homeless people using the services of a mobile health clinic in relation to their health needs: a qualitative study on community-based outreach nursing.
- Author
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Fordham M
- Published
- 2023
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47. Do Women in Nepal Like Playing a Mobile Game? MANTRA: A Mobile Gamified App for Improving Healthcare Seeking Behavior in Rural Nepal.
- Author
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Kayastha R, Mueller S, Yadav P, Kelman I, Boscor A, Saville N, Arjyal A, Baral S, Fordham M, Hearn G, and Kostkova P
- Subjects
- Child, Delivery of Health Care, Female, Humans, Nepal, Rural Population, Mobile Applications, Video Games
- Abstract
In Low and Middle Income Countries (LMIC), one of the causes of maternal and child mortality is a lack of medical knowledge and consequently the inability to seek timely healthcare. Mobile health (mHealth) technology is gradually becoming a universal intervention platform across the globe due to ubiquity of mobile phones and network coverage. MANTRA is a novel mHealth intervention developed to tackle maternal and child health issues through a serious mobile game app in rural Nepal, which demonstrated a statistically significant knowledge improvement in rural women. This paper explores the perceptions and usability of the MANTRA app amongst rural women and Female Community Health Volunteers (FCHVs) in Nepal. Despite the challenges of a target user group with limited educational levels and low smartphone experience, all participants viewed the MANTRA app with approval and enthusiasm. They were willing to engage further with the mHealth intervention and to share their experience and knowledge with fellow community members. Participants also showed an increase in awareness of danger signs enabling them to make better informed health decisions in the future. FCHVs viewed the app as a validation tool providing and support for greater impact of their efforts in rural Nepal. Growing mobile ownership, network coverage and availability of smartphones along with acceptance of the prototype MANTRA app in rural communities suggest encouraging prospects for mHealth interventions to be incorporated in the national health infrastructure in Nepal and other LMICs., Competing Interests: GH was employed by the company Hearn Geoserve, Ltd. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2021 Kayastha, Mueller, Yadav, Kelman, Boscor, Saville, Arjyal, Baral, Fordham, Hearn and Kostkova.)
- Published
- 2021
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48. MANTRA: Improving Knowledge of Maternal Health, Neonatal Health, and Geohazards in Women in Rural Nepal Using a Mobile Serious Game.
- Author
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Mueller S, Soriano D, Boscor A, Saville NM, Arjyal A, Baral S, Fordham M, Hearn G, Kayastha R, and Kostkova P
- Subjects
- Child, Female, Humans, Infant Health, Infant, Newborn, Maternal Health, Nepal, Mobile Applications, Video Games
- Abstract
Serious games, conveying educational knowledge rather than merely entertainment, are a rapidly expanding research domain for cutting-edge educational technology. Digital interventions like serious games are great opportunities to overcome challenges in low-and-middle-income countries that limit access to health information, such as social barriers like low-literacy and gender. MANTRA: Increasing maternal and child health resilience before, during and after disasters using mobile technology in Nepal takes on these challenges with a novel digital health intervention; a serious mobile game aimed at vulnerable low-literacy female audiences in rural Nepal. The serious game teaches 28 learning objectives of danger signs in geohazards, maternal, and neonatal health to improve knowledge and self-assessment of common conditions and risks to inform healthcare-seeking behavior. Evaluations consisted of recruiting 35 end users to participate in a pre-test assessment, playing the game, post-test assessment, and focus groups to elicit qualitative feedback. Assessments analyzed knowledge gain in two ways; by learning objective with McNemar tests for each learning objective, and by participant scores with paired t -tests of overall scores and by module. Results of assessments of knowledge gain by learning objective (McNemar tests) indicate participants had sufficient prior knowledge to correctly interpret and respond to 26% of pictograms (coded AA), which is a desirable result although without the possibility of improvement through the intervention. The geohazard module had greatest impact as 16% of responses showed knowledge gain (coded BA). The two most successful learning objectives showing statistically significant positive change were evidence of rockfalls and small cracks in the ground ( p = < 0.05). Assessment of knowledge gain by participant scores (paired t -tests) showed the 35 participants averaged a 7.7 point improvement ( p < 0.001) in the assessment (28 learning objectives). Average change in knowledge of subdivided module scores (each module normalized to 100 points for comparison) was greatest in the geohazard module (9.5 points, p < 0.001), then maternal health (7.4 points, p = 0.0067), and neonatal health (6.0 points, p = 0.013). This evaluation demonstrated that carefully designed digital health interventions with pictograms co-authored by experts and users can teach complex health and geohazard situations. Significant knowledge gain was demonstrated for several learning objectives while those with non-significant or negative change will be re-designed to effectively convey information., Competing Interests: GH was employed by the company Hearn Geoserve, Ltd. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2020 Mueller, Soriano, Boscor, Saville, Arjyal, Baral, Fordham, Hearn, Kayastha and Kostkova.)
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- 2020
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49. MANTRA: development and localization of a mobile educational health game targeting low literacy players in low and middle income countries.
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Mueller S, Soriano D, Boscor A, Saville N, Arjyal A, Baral S, Fordham M, Hearn G, Le Masson V, Kayastha R, and Kostkova P
- Subjects
- Developing Countries, Female, Humans, Literacy, Nepal, Rural Population statistics & numerical data, Telemedicine methods, Health Education methods, Mobile Applications statistics & numerical data, Play and Playthings, Rural Health Services organization & administration
- Abstract
Background: Mobile technology is increasingly important for delivering public health interventions to remote populations. This research study developed, piloted, and assessed a serious game for mobile devices that teaches geohazard, maternal, and neonatal health messages. This unique mHealth intervention aimed at low-literacy audiences in low resource settings is part of the Maternal and Neonatal Technologies in Rural Areas (MANTRA) project: Increasing maternal and child health resilience before, during, and after disasters using mobile technology in Nepal., Methods: The serious game was developed through a co-creation process between London and Kathmandu based researchers by email and video-calling, and face-to-face with local stakeholders in Nepal. The process identified core needs, developed appropriate pictograms and mechanics, and tailored the pilot serious game to the local cultural context. Evaluations and feedback from end users took place in rural villages and suburban Kathmandu in Province Three. Field evaluation sessions used mixed methods. Researchers observed game play and held focus group discussions to elicit qualitative feedback and understand engagement, motivation, and usability, and conducted a paired pre- and post-game knowledge assessment., Results: The MANTRA serious game is contextualized to rural Nepal. The game teaches 28 learning objectives in three modules: maternal health, neonatal health, and geohazards, through picture matching with immediate audio and visual feedback. User feedback from focus groups demonstrated high engagement, motivation, and usability of the game., Conclusions: This MANTRA study is a unique mHealth intervention of a serious game to teach core health and geohazards messages to low-literacy audiences in rural Nepal. Although the mobile game is tailored for this specific context, the developmental process and insights could be transferable to the development of other games-based interventions and contextualized for any part of the world. Successfully targeting this low-literacy and illiterate audience makes the MANTRA development process the first of its kind and a novel research endeavor with potential for widespread impact and adoption following further game development., Trial Registration: This project was approved by the University College London Ethics Committee in London, United Kingdom [10547/001], and the Nepal Health Research Council in Kathmandu, Nepal [Reg. No. 105/2017]. All participants provided informed written consent.
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- 2020
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50. GYY4137, a Hydrogen Sulfide Donor Modulates miR194-Dependent Collagen Realignment in Diabetic Kidney.
- Author
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John AMSP, Kundu S, Pushpakumar S, Fordham M, Weber G, Mukhopadhyay M, and Sen U
- Subjects
- Animals, Disease Models, Animal, Endothelial Cells, Hydrogen Sulfide metabolism, Mice, Treatment Outcome, Collagen metabolism, Diabetic Nephropathies drug therapy, Diabetic Nephropathies pathology, Matrix Metalloproteinases metabolism, MicroRNAs metabolism, Morpholines administration & dosage, Organothiophosphorus Compounds administration & dosage, Poly (ADP-Ribose) Polymerase-1 metabolism
- Abstract
The relationship between hydrogen sulfide (H
2 S), microRNAs (miRs), matrix metalloproteinases (MMPs) and poly-ADP-ribose-polymerase-1 (PARP-1) in diabetic kidney remodeling remains mostly obscured. We aimed at investigating whether alteration of miR-194-dependent MMPs and PARP-1 causes renal fibrosis in diabetes kidney, and whether H2 S ameliorates fibrosis. Wild type, diabetic Akita mice as well as mouse glomerular endothelial cells (MGECs) were used as experimental models, and GYY4137 as H2 S donor. In diabetic mice, plasma H2 S levels were decreased while ROS and expression of its modulator (ROMO1) were increased. In addition, alteration of MMPs-9, -13 and -14 expression, PARP-1, HIF1α, and increased collagen biosynthesis as well as collagen cross-linking protein, P4HA1 and PLOD2 were observed along with diminished vascular density in diabetic kidney. These changes were ameliorated by GYY4137. Further, downregulated miRNA-194 was normalized by GYY4137 in diabetic kidney. Similar results were obtained in in vitro condition. Interestingly, miR-194 mimic also diminished ROS production, and normalized ROMO1, MMPs-9, -13 and -14, and PARP-1 along with collagen biosynthesis and cross-linking protein in HG condition. We conclude that decrease H2 S diminishes miR-194, induces collagen deposition and realignment leading to fibrosis and renovascular constriction in diabetes. GYY4137 mitigates renal fibrosis in diabetes through miR-194-dependent pathway.- Published
- 2017
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