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11 results on '"Fjeldbo, Christina S"'

1. Integrated analysis of cervical squamous cell carcinoma cohorts from three continents reveals conserved subtypes of prognostic significance

Author

Chakravarthy, Ankur, Reddin, Ian, Henderson, Stephen, Dong, Cindy, Kirkwood, Nerissa, Jeyakumar, Maxmilan, Rodriguez, Daniela Rothschild, Martinez, Natalia Gonzalez, McDermott, Jacqueline, Su, Xiaoping, Egawa, Nagayasau, Fjeldbo, Christina S., Skingen, Vilde Eide, Lyng, Heidi, Halle, Mari Kyllesø, Krakstad, Camilla, Soleiman, Afschin, Sprung, Susanne, Lechner, Matt, Ellis, Peter J. I., Wass, Mark, Michaelis, Martin, Fiegl, Heidi, Salvesen, Helga, Thomas, Gareth J., Doorbar, John, Chester, Kerry, Feber, Andrew, and Fenton, Tim R.

Published
2022
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2. ALDH1A1 drives prostate cancer metastases and radioresistance by interplay with AR- and RAR-dependent transcription.

Author

Gorodetska, Ielizaveta, Offermann, Anne, Püschel, Jakob, Lukiyanchuk, Vasyl, Gaete, Diana, Kurzyukova, Anastasia, Freytag, Vera, Haider, Marie-Therese, Fjeldbo, Christina S., Di Gaetano, Simona, Schwarz, Franziska Maria, Patil, Shivaprasad, Borkowetz, Angelika, Erb, Holger H. H., Baniahmad, Aria, Mircetic, Jovan, Lyng, Heidi, Löck, Steffen, Linge, Annett, and Lange, Tobias

Published
2024
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4. miR‐200a/b/‐429 downregulation is a candidate biomarker of tumor radioresistance and independent of hypoxia in locally advanced cervical cancer

Author

Nilsen, Anja, primary, Hillestad, Tiril, additional, Skingen, Vilde E., additional, Aarnes, Eva‐Katrine, additional, Fjeldbo, Christina S., additional, Hompland, Tord, additional, Evensen, Tina Sandø, additional, Stokke, Trond, additional, Kristensen, Gunnar B., additional, Grallert, Beata, additional, and Lyng, Heidi, additional

Published
2022
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5. Pro-metastatic gene expression, immune evasion and an altered HPV spectrum characterize an aggressive subtype of cervical cancer

Author

Chakravarthy, Ankur, Henderson, Stephen, Dong, Cindy, Kirkwood, Nerissa, Jeyakumar, Maxmilan, McDermott, Jacqueline, Su, Xiaoping, Egawa, Nagayasau, Fjeldbo, Christina S, Halle, Mari Kyllesø, Krakstad, Camilla, Soleiman, Afschin, Sprung, Susanne, Lyng, Heidi, Fiegl, Heidi, Salvesen, Helga, Doorbar, John, Chester, Kerry, Feber, Andrew, and Fenton, Tim R

Abstract

Cervical cancer is caused by carcinogenic human papillomavirus infection and represents one of the leading causes of cancer death worldwide. Effective means of tumour classification are required for better disease understanding. We performed an integrated multi-omic analysis of 655 cervical cancers, using epigenomic and transcriptomic signatures to discover two distinct cervical cancer subtypes we named “typical” and “atypical”. Typical tumours were largely HPV16-driven and frequently displayed an ‘immune-hot’ tumour microenvironment. Atypical tumours were associated with poor prognosis; they were more likely to be driven by HPVs from the HPV18-containing α7 clade, displayed distinct genomic aberrations, greater evidence of past immunoediting and a microenvironment associated with immune-evasion and failure of anti-PD1 checkpoint inhibition. The finding that atypical tumours encounter stronger anti-tumour immune responses during development may explain the lower frequency at which α7 HPV infected-lesions progress from pre-invasive disease. However those escaping this selection pressure evolve into aggressive tumours (independent of HPV-type) in which more intensive adjuvant treatment may be warranted.

Published
2020
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6. MRI Distinguishes Tumor Hypoxia Levels of Different Prognostic and Biological Significance in Cervical Cancer

Author

Hillestad, Tiril, primary, Hompland, Tord, additional, Fjeldbo, Christina S., additional, Skingen, Vilde E., additional, Salberg, Unn Beate, additional, Aarnes, Eva-Katrine, additional, Nilsen, Anja, additional, Lund, Kjersti V., additional, Evensen, Tina S., additional, Kristensen, Gunnar B., additional, Stokke, Trond, additional, and Lyng, Heidi, additional

Published
2020
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8. Integrative Analysis of DCE-MRI and Gene Expression Profiles in Construction of a Gene Classifier for Assessment of Hypoxia-Related Risk of Chemoradiotherapy Failure in Cervical Cancer

Author

Fjeldbo, Christina S., primary, Julin, Cathinka H., additional, Lando, Malin, additional, Forsberg, Malin F., additional, Aarnes, Eva-Katrine, additional, Alsner, Jan, additional, Kristensen, Gunnar B., additional, Malinen, Eirik, additional, and Lyng, Heidi, additional

Published
2016
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11. The duration of gastrin treatment affects global gene expression and molecular responses involved in ER stress and anti-apoptosis

Author

Selvik, Linn-Karina M, primary, Fjeldbo, Christina S, additional, Flatberg, Arnar, additional, Steigedal, Tonje S, additional, Misund, Kristine, additional, Anderssen, Endre, additional, Doseth, Berit, additional, Langaas, Mette, additional, Tripathi, Sushil, additional, Beisvag, Vidar, additional, Lægreid, Astrid, additional, Thommesen, Liv, additional, and Bruland, Torunn, additional

Published
2013
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