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3. DNMT3A overgrowth syndrome is associated with the development of hematopoietic malignancies in children and young adults.

Author

Ferris MA, Smith AM, Heath SE, Duncavage EJ, Oberley M, Freyer D, Wynn R, Douzgou S, Maris JM, Reilly AF, Wu MD, Choo F, Fiets RB, Koene S, Spencer DH, Miller CA, Shinawi M, and Ley TJ

Subjects
Adolescent, Adult, Child, Child, Preschool, Congenital Abnormalities genetics, Female, Germ-Line Mutation, Humans, Male, Syndrome, Young Adult, DNA Methyltransferase 3A genetics, Hematologic Neoplasms genetics, Mutation
Published
2022
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4. Coronary artery spasms due to tyrosine kinase inhibitors used in chronic myeloid leukemia.

Author

Fiets RB, Staal AHJ, Cramer GE, and Blijlevens NMA

Subjects
Humans, Male, Middle Aged, Antineoplastic Agents adverse effects, Coronary Vasospasm chemically induced, Coronary Vasospasm diagnosis, Dasatinib adverse effects, Leukemia, Myelogenous, Chronic, BCR-ABL Positive drug therapy, Protein-Tyrosine Kinases antagonists & inhibitors
Abstract

Tyrosine kinase inhibitors (TKIs) have changed the landscape of treatment for patients with chronic myeloid leukemia (CML) leading to a life expectancy comparable to the general population. Side effects commonly encountered during TKI treatment are pleural effusion due to use of dasatinib and vascular side effects due to nilotinib and ponatinib. Coronary artery spasm (CAS), although encountered during treatment with other chemotherapeutic drugs, have to our knowledge never been reported during TKI treatment. Here, we describe two cases of coronary artery spasms which are likely due to TKIs.

Published
2018

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