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Background and aims: One of the most common endocrine disorders affecting females during their reproductive years is polycystic ovary syndrome (PCOS), which is associated with symptoms such as dysmenorrhea, infertility, hirsutism, acne, and obesity. This study aimed to induce a polycystic ovary model in female adult rats through a single injection of estradiol valerate. Methods: In this experimental study, 50 adult female rats were divided into four groups: PCO+1 (N=15), PCO+2 (N=15), control (N=10), and sham (N=10). The PCO+1 and PCO+2 groups received subcutaneous injections of estradiol valerate at doses of 1 mg and 2 mg, respectively, combined with 0.2 ml of olive oil. The sham group received a subcutaneous injection of 0.2 ml of olive oil, while the control group underwent no intervention. Body and ovarian weights were measured, and histological analyses were performed to count ovary follicles. Results: A significant increase in weight was observed in the PCO+2 group compared to the other groups. The numbers of primary, secondary, and mature follicles, as well as corpora lutea, were lower in the PCO+2 group compared to the others. However, there was no significant difference in the number of atretic follicles. Notably, the PCO+2 group showed a significant increase in the number of cystic follicles compared to the other groups. Conclusion: The results of this study indicate that a single injection of 2 mg of estradiol valerate effectively induces a polycystic ovary model, characterized by the presence of cystic follicles and a reduction in mature follicles. [ABSTRACT FROM AUTHOR]

Aim and Background. This study aims to explore alternative diagnostic methods to assess thyroid function in patients unable to undergo blood tests for thyroid-stimulating hormones (TSH) and thyroxine (T4), such as individuals with trypanophobia, severe medical conditions, or coagulopathy. Considering the impact of thyroid dysfunction on mitochondrial metabolism and the essential role of proper mitochondrial function in ciliary motility, we postulate that assessing nasal ciliary function could serve as a surrogate diagnostic approach for thyroid dysfunction. Methods. This cross-sectional study was performed on individuals with no history of thyroid diseases. The primary endpoint was the diagnostic value of the nasal mucociliary (NMC) test using Iranica Picris (Asteraceae) aqueous extract in differentiating hypo- or hyperthyroidism cases from euthyroid cases. Results. 232 individuals were recruited (71% females, 86% euthyroid). Receiver operating characteristic (ROC) analysis showed a good diagnostic value for the NMC test in differentiating overt hypothyroidism (area under the ROC curve [AUROC] = 0.82, p = 0.004) and its fair value in diagnosing subclinical hyperthyroidism (AUROC = 0.78, p = 0.01) from the euthyroid condition. The NMC test had a significant positive correlation with TSH (r = 0.47, p < 0.001) and a significant negative correlation with T4 (r = −0.32, p < 0.001). The NMC rate was significantly different in distinct thyroid function groups (p < 0.001). Compared with euthyroid cases, the post-hoc analysis showed that the NMC test is significantly higher in overt hypothyroidism (15.06 vs. 21.07 min, p = 0.003) and significantly lower in subclinical hyperthyroidism (15.05 vs. 10.9 min, p = 0.02). Conclusions. The Iranica Picris-based NMC test might serve as a diagnostic method to distinguish overt hypothyroidism and subclinical hyperthyroidism. [ABSTRACT FROM AUTHOR]

In this article, the authors have sought to develop and present an optimal model of Iran's countermeasures against the threats of the economic plans of the major powers in Central Asia. This qualitative research uses mixed-methods (i.e., thematic matrix and thematic network) to collect and analyze data. Since the thematic matrix was used as a data analysis method, an indirect observation study (analysis of textual material) was performed, data were collected through a purposeful sampling of existing textual materials, and finally, a comparison and an analysis were made to specify commonalities and differences. In addition, since the thematic network, research data were collected using a semi-structured interview with 10 experts, who were selected using theoretical sampling; the collected data were analyzed using the thematic network analysis method. Eventually, a conceptual network model was constructed and interpreted. Findings of qualitative research while identifying opportunities and threats revealed that the optimal model of Iran's countermeasures against the economic plans of the major powers in Central Asia with three global themes, including the adoption of economic diplomacy by Iran, the adoption of soft diplomacy by Iran, and efforts to exit sanctions and remove sanction barriers, had reached theoretical saturation. The most appropriate strategy for Iran to confront the threats of the economic plans of the major powers in Central Asia is to adopt convergent diplomacy in the form of various kinds of diplomacy and the removal of the sanction barriers. [ABSTRACT FROM AUTHOR]

Introduction: Recent advances have led to the development of sialendoscopy, an accurate, minimally invasive procedure with high diagnostic and therapeutic capabilities in treating sialolithiasis. This study aimed to evaluate the results and complications of sialendoscopy in patients suffering from sialoadenitis. Materials and Methods: This study was a prospective interventional case series study on patients with sialoadenitis due to sludge or stone formation preoperatively confirmed by sonography or computed tomography (CT) scanning. Diagnostic sialendoscopy was performed, and the presence of stenosis, sludge, or stones inside the gland or duct was examined, and surgery was done. During follow-up time (18.8 ± 7.4 months), recurrence of symptoms, the need for reoperation, and postoperative complications were also assessed. Results: The sialendoscopy was performed in 51 patients, including 55 glands. Forty-five Patients (88.2%) reported pain relief, and 46 patients (90.2%) reported that the treatment using sialendoscopy was better than conservative methods. The duct restenosis also occurred in one patient requiring open surgery. In assessing the main factors predicting the need for reoperation, the site of involvement (parotid versus submandibular glands) and the size of the stone were identified as the main determinants. The best cutoff value for stone size in predicting reoperation requirement was 7.0mm, with a sensitivity of 100% and a specificity of 85.7%. Conclusion: Intraoperative sialendoscopy is a successful diagnostic and therapeutic tool with minimal postoperative complications in salivary gland duct involvement patients. [ABSTRACT FROM AUTHOR]

Introduction Cigarette smoking is the single largest preventable cause of death and disability in the industrialized world and it causes at least 85% of lung cancers, chronic bronchitis and emphysema. In addition smokers are at a higher risk from psychiatric co-morbid illness such as depression and completed suicide. Methods We conducted a cross-sectional survey in which we targeted all patients with serious mental illness (SMI) who were admitted in Razi mental health Hospital in Tehran, Iran. We recruited 984 participants, who were receiving services from Razi mental health Hospital and hospitalized for at least two days between 21 July to 21 September, 2010. Nine hundred and fifty patients out of this figure were able to participate in our study. Results The final study sample (n = 950) consisted of 73.2% males and 26.8% females. The mean age was 45.31 (SD=13.7). A majority of participants (70%) was smoker. A history of never smoking was present for 25.2% of the study sample; while 4.8% qualified as former smokers and 70.0% as occasional or current smokers. Two hundred and nineteen participants had attempted suicide amongst them 102 (46.6%) once, 37 (16.9%) twice, and 80 (36.5%) attempted more than two times in their life time. In regression model, gender, age, and cigarette consumption were associated with previous suicide attempts and entered the model in this order as significant predictors. Conclusions There is an association of cigarette smoking and suicide attempt in psychiatric inpatients. Current smoking, a simple clinical assessment, should trigger greater attention by clinicians to potential suicidality and become part of a comprehensive assessment of suicide risk.

Introduction: Olfactory training is accounted as a significantly beneficial therapy for hyposmia or anosmia. There is some evidence about methylxanthine usage for this issue. In the present study, we have investigated the effects of topical aminophylline in hyposmic and anosmic patients. Materials and Methods: In this clinical trial study, patients were randomly divided into two groups (n= 20/each), the case group was given aminophylline drops over a three-month period (using the contents of the vial aminophylline in the form of nasal drops, 250 micrograms daily) with olfactory training and the control group was given normal saline drops with olfactory training over a three-month period. The olfactory capacities were assessed before the start and after the completion of treatments using a valid and reliable smell identification test. Results: In the saline and aminophylline groups, the mean ± SD relative changes in SIT score were 0.55±0.31 and 0.85±0.56, respectively. As a result, the SIT score in the saline group climbed by 55 percent but increased by 85 percent in the aminophylline group. The difference in SIT score between pre- and posttest was meaningful in both groups (P< 0.001). The aminophylline group scored significantly higher according to the marginal longitudinal regression model, adjusting baseline parameters. Conclusions: Intranasal aminophylline plus olfactory training significantly improved SIT scores in severe hyposmia or anosmia. Hypothetically, these effects are mediated through changes in cAMP and cGMP. [ABSTRACT FROM AUTHOR]