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10. Association of gallstone and polymorphisms of UGT1A1*27 and UGT1A1*28 in patients with hepatitis B virus-related liver failure

Author

Zhuo Haiyan, Fan Jinhai, Zhang Bifeng, Shi Yixian, Zheng Liqing, Chai Yihong, and Yao Lvfeng

Subjects
ugt1a1, gallstone, liver failure, hepatitis b virus, single-nucleotide polymorphism, Medicine
Abstract

Genetic variation in UDP-glucuronosyltransferase 1A1 gene (UGT1A1) is a lithogenic risk factor for gallstone formation. This study aimed to assess genotype and allele frequencies of common UGT1A1 variants in patients with gallstone and hepatitis B virus (HBV)-related hepatic failure. This study enrolled 113 healthy individuals (CTRL), 54 patients with HBV infection (HBV), 134 patients with gallstone-free hepatic failure and HBV infection, and 34 patients with gallstone-related hepatic failure and HBV infection (GRHF). Peripheral venous blood samples were collected for genomic DNA isolation. Polymerase chain reaction amplification was carried out for UGT1A1, followed by direct sequencing. Analysis for genotype and allele frequencies of UGT1A1 variants (UGT1A1*6, UGT1A1*27, UGT1A1*28, and UGT1A1*60) was performed. The allele distributions of the four groups did not deviate from Hardy–Weinberg equilibrium. Allele (A) and genotype (CA) frequency distributions of UGT1A1*27 were significantly different between GRHF and CTRL, or between GRHF and HBV. GRHF and CTRL exhibited significant differences in allele (A) and genotype (CA) frequency distributions of UGT1A1*28. Linkage disequilibrium analysis suggested that haplotype G-G-[TA]7-T may be associated with gallstone in HBV-related hepatic failure. Our data reveal that UGT1A1*27 and UGT1A1*28 variants are significantly observed in patients with GRHF compared to healthy individuals.

Published
2022
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12. Enhanced Tumor‐Targeted Delivery of Arginine‐Rich Peptides via a Positive Feedback Loop Orchestrated by Piezo1/integrin β1 Signaling Axis.

Author

Ma, Minghai, Li, Xing, Jing, Minxuan, Zhang, Pu, Zhang, Mengzhao, Wang, Lu, Liang, Xiao, Jiang, Yunzhong, Li, Jianpeng, He, Jiale, Wang, Xinyang, Lin, Min, Wang, Lei, and Fan, Jinhai

Abstract

Peptide‐based drugs hold great potential for cancer treatment, and their effectiveness is driven by mechanisms on how peptides target cancer cells and escape from potential lysosomal entrapment post‐endocytosis. Yet, the mechanisms remain elusive, which hinder the design of peptide‐based drugs. Here hendeca‐arginine peptides (R11) are synthesized for targeted delivery in bladder carcinoma (BC), investigated the targeting efficiency and elucidated the mechanism of peptide‐based delivery, with the aim of refining the design and efficacy of peptide‐based therapeutics. It is demonstrated that the over‐activated Piezo1/integrin β1 (ITGB1) signaling axis significantly facilitates tumor‐targeted delivery of R11 peptides via macropinocytosis. Furthermore, R11 peptides formed hydrogen bonds with integrin β1, facilitating targeting and penetration into tumor cells. Additionally, R11 peptides protected integrin β1 from lysosome degradation, promoting its recycling from cytoplasm to membrane. Moreover, this findings establish a positive feedback loop wherein R11 peptides activate Piezo1 by increasing membrane fusion, promoting Ca2+ releasing and resulting in enhanced integrin β1‐mediated endocytosis in both orthotopic models and clinical tissues, demonstrating effective tumor‐targeted delivery. Eventually, the Piezo1/integrin β1 signaling axis promoted cellular uptake and transport of peptides, establishing a positive feedback loop, promoting mechanical delivery to cancer and offering possibilities for drug modification in cancer therapy. [ABSTRACT FROM AUTHOR]

Published
2024
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14. Survival after radical cystectomy for bladder cancer: Multicenter comparison between minimally invasive and open approaches

Author

Xie, Weibin, Bi, Junming, Wei, Qiang, Han, Ping, Song, Dongkui, Shi, Lei, Ye, Dingwei, Shen, Yijun, Gou, Xin, He, Weiyang, Wang, Shaogang, Liu, Zheng, Fan, Jinhai, Wu, Kaijie, Chen, Zhiwen, Zhou, Xiaozhou, Kong, Chuize, Liu, Yang, Liu, Chunxiao, Xu, Abai, Jin, Baiye, Fu, Guanghou, Xue, Wei, Chen, Haige, Pan, Tiejun, Tu, Zhong, Lin, Tianxin, and Huang, Jian

Published
2020
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16. Urinary Tumor DNA MRD Analysis to Identify Responders to Neoadjuvant Immunotherapy in Muscle-invasive Bladder Cancer

Author

Zhang, Ruiyun, primary, Zang, Jingyu, additional, Jin, Di, additional, Xie, Feng, additional, Shahatiaili, Akezhouli, additional, Wu, Guangyu, additional, Zhang, Lu, additional, Wang, Lu, additional, Zhang, Yue, additional, Zhao, Zhixin, additional, Du, Pan, additional, Jia, Shidong, additional, Fan, Jinhai, additional, Zhuang, Guanglei, additional, and Chen, Haige, additional

Published
2023
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20. Efficacy and safety of a novel 450 nm blue diode laser versus plasmakinetic electrocautery for the transurethral resection of non-muscle invasive bladder cancer: The protocol and result of a multicenter randomized controlled trial

Author

Wu, Kaijie, primary, Jiang, Dali, additional, Zhang, Lianhua, additional, Jiang, Shuai, additional, Lin, Tianhai, additional, Luo, Yi, additional, Fan, Jinhai, additional, Yang, Tao, additional, Chen, Haige, additional, Zhang, Peng, additional, Wang, Xinghuan, additional, Wei, Qiang, additional, Guo, Jianming, additional, Huang, Yiran, additional, and He, Dalin, additional

Published
2023
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24. Identification of a six-gene prognostic signature for bladder cancer associated macrophage

Author

Jiang, Yunzhong, Qu, Xiaowei, Zhang, Mengzhao, Zhang, Lu, Yang, Tao, Ma, Minghai, Jing, Minxuan, Zhang, Nan, Song, Rundong, Zhang, Yuanquan, Yang, Zezhong, Zhang, Yaodong, Pu, Yuanchun, and Fan, Jinhai

Subjects
Gene Expression Regulation, Neoplastic, Urinary Bladder Neoplasms, Gene Expression Profiling, Macrophages, Immunology, Biomarkers, Tumor, Tumor Microenvironment, Humans, Immunology and Allergy, Folate Receptor 2, Prognosis, Adaptor Proteins, Signal Transducing
Abstract

As major components of the tumor microenvironment (TME), tumor-associated macrophages (TAMs) play an exceedingly complicated role in tumor progression and tumorigenesis. However, few studies have reported the specific TAM gene signature in bladder cancer. Herein, this study focused on developing a TAM-related prognostic model in bladder cancer patients based on The Cancer Genome Atlas (TCGA) data. Weighted Gene Co-Expression Network Analysis (WGCNA) was used to identify key genes related to TAM (M2 macrophage). Gene ontology (GO) enrichment and the Kyoto Encyclopedia of Genes and Genomes (KEGG) signaling pathway analysis showed the functional categories of the key genes. Simultaneously, we used the Least Absolute Shrinkage and Selection Operator (LASSO) and univariate and multivariate Cox regressions to establish a TMA-related prognostic model containing six key genes: TBXAS1, GYPC, HPGDS, GAB3, ADORA3, and FOLR2. Subsequently, single-cell sequencing data downloaded from Gene Expression Omnibus (GEO) suggested that the six genes in the prognostic model were expressed in TAM specifically and may be involved in TAM polarization. In summary, our research uncovered six-TAM related genes that may have an effect on risk stratification in bladder cancer patients and could be regarded as potential TAM-related biomarkers.

Published
2022

26. Global, Regional, and National Burden of Urolithiasis from 1990 to 2019: A Systematic Analysis for the Global Burden of Disease Study 2019

Author

Zhang,Lu, Zhang,Xu, Pu,Yuanchun, Zhang,Yaodong, Fan,Jinhai, Zhang,Lu, Zhang,Xu, Pu,Yuanchun, Zhang,Yaodong, and Fan,Jinhai

Abstract

Lu Zhang,1,* Xu Zhang,2,* Yuanchun Pu,1,* Yaodong Zhang,1 Jinhai Fan1,3 1Department of Urology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, People’s Republic of China; 2Department of Gastroenterology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, People’s Republic of China; 3Oncology Research Lab, Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education, Xi’an, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jinhai Fan, Department of Urology, The First Affiliated Hospital of Xi’an Jiaotong University, #277 Yanta West Road, Xi’an, 710061, People’s Republic of China, Tel +86-29-8532-3661, Fax +86-29-8532-3203, Email jinhaif029@126.comIntroduction: To get insight into the temporal trends of urolithiasis, and thus decrease the health burden of urolithiasis, we comprehensively investigated the specific epidemiological indicators that varied among different countries and regions according to the diversity of geographic locations, gender, age, year, and socioeconomic status.Methods: In this study, we investigated the incidence, death, disability-adjusted life years (DALYs) of urolithiasis quantified by the number of patients, age-standardized rates, and estimated annual percentage changes based on geographic locations, gender, age, and year to decode the epidemiological characteristics using the data from 1990 to 2019 in the Global Burden of Disease database.Results: In 2019, more than 115 million (95% uncertainty interval [95% UI] 93– 140) incident cases of urolithiasis occurred worldwide, and the age-standardized incidence rate (ASIR) (per 100,000 population) decreased from 1696.2 (1358.1– 2078.1) in 1990 to 1394 (1126.4– 1688.2) in 2019. Nearly 13,279 (95% UI: 10616– 16267) died of urolithiasis, contributing to 0.6 million (0.5– 0.7) DALYs in 2019. The highest age-standardized DALY rates (33.33 per

Published
2022

28. Safety, Efficacy, and Biomarker Analysis of Toripalimab in Patients with Previously Treated Advanced Urothelial Carcinoma: Results from a Multicenter Phase II Trial POLARIS-03

Author

Sheng, Xinan, primary, Chen, Haige, additional, Hu, Bin, additional, Yao, Xudong, additional, Liu, Ziling, additional, Yao, Xin, additional, Guo, Hongqian, additional, Hu, Yi, additional, Ji, Zhigang, additional, Luo, Hong, additional, Shi, Benkang, additional, Liu, Jiyan, additional, Wu, Jin, additional, Zhou, FangJian, additional, He, Zhisong, additional, Fan, Jinhai, additional, Wang, Weifeng, additional, Feng, Hui, additional, Yao, Sheng, additional, Keegan, Patricia, additional, Huang, Yiran, additional, and Guo, Jun, additional

Published
2022
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30. Identification of CCL4 as an Immune-Related Prognostic Biomarker Associated With Tumor Proliferation and the Tumor Microenvironment in Clear Cell Renal Cell Carcinoma

Author

Zhang, Lu, primary, Zhang, Mengzhao, additional, Wang, Lu, additional, Li, Jianlong, additional, Yang, Tao, additional, Shao, Qiuya, additional, Liang, Xiao, additional, Ma, Minghai, additional, Zhang, Nan, additional, Jing, Minxuan, additional, Song, Rundong, additional, and Fan, Jinhai, additional

Published
2021
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33. Thymoquinone suppresses invasion and metastasis in bladder cancer cells by reversing EMT through the Wnt/β-catenin signaling pathway

Author

Zhang, Mengzhao, primary, Du, Hongxia, additional, Wang, Lu, additional, Yue, Yangyang, additional, Zhang, Pu, additional, Huang, Zhixin, additional, Lv, Wei, additional, Ma, Jianbin, additional, Shao, Qiuya, additional, Ma, Minghai, additional, Liang, Xiao, additional, Yang, Tao, additional, Wang, Weiyi, additional, Zeng, Jin, additional, Chen, Guanqiu, additional, Wang, Xinyang, additional, and Fan, Jinhai, additional

Published
2020
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35. TNIP1 Inhibits Proliferation And Promotes Apoptosis In Clear Cell Renal Carcinoma Through Targeting C/Ebpβ

Author

Yang,Yong, Fan,Jinhai, Han,Shenglu, and Li,Enyuan

Subjects
OncoTargets and Therapy
Abstract

Yong Yang,1 Jinhai Fan,2 Shenglu Han,1 Enyuan Li1 1Department of Urology, The Ninth Hospital of Xi’an, Xi’an, Shaanxi, People’s Republic of China; 2Department of Urology, The First Affiliated Hospital of Xi’an JiaoTong University, Xi’an, Shaanxi, People’s Republic of ChinaCorrespondence: Yong YangDepartment of Urology, The Ninth Hospital of Xi’an, 151 East Section of South Second Ring Road, Xi ‘an, Shaanxi 710054, People’s Republic of ChinaTel +86 135 7197 6611Email yangyongdr@sina.comBackground/Purpose: TNF-α-induced protein 3-interacting protein 1 (TNIP1) is active in various cancers, but its expression and function in renal cell carcinoma (RCC) have not been described. This study investigated the role of TNIP1 in clear cell renal cell carcinomas (ccRCC), which accounts for 75–80% of RCC and has a poor prognosis.Methods: The expression of TNIP1 in human ccRCC tissues and cells was detected by real-time quantitative reverse transcription–polymerase chain reaction (qRT-PCR), Western blot (WB), and immunohistochemical (IHC) staining. Cell proliferation was assayed by a cell counting kit (CCK)-8 assay; cell cycle analysis and apoptosis assay were done by flow cytometry.Results: TNIP1 is downregulated in both ccRCC human tissues and cells. Besides, TNIP1 downregulation promoted cell proliferation with more cell cycle entry, and inhibited apoptosis. TNIP1 downregulation was associated with increased of expression of the Bcl-2 anti-apoptosis gene and decreased expression of the Bax apoptosis-promoting gene and cleaved-caspase-3 by negatively regulating C/EBPβ expression.Conclusion: TNIP1 acted as a tumor-inhibitor in ccRCC by targeting C/EBPβ. The results warrant study of TNIP1 as a potential diagnostic marker and therapeutic target of ccRCC.Keywords: ccRCC, TNIP1, C/EBPβ, proliferation, apoptosis

Published
2019

38. RASAL2, a RAS GTPase-activating protein, inhibits stemness and epithelial–mesenchymal transition via MAPK/SOX2 pathway in bladder cancer

Author

Hui, Ke, primary, Gao, Yang, additional, Huang, Jun, additional, Xu, Shan, additional, Wang, Bin, additional, Zeng, Jin, additional, Fan, Jinhai, additional, Wang, Xinyang, additional, Yue, Yangyang, additional, Wu, Shiqi, additional, Hsieh, Jer-Tsong, additional, He, Dalin, additional, and Wu, Kaijie, additional

Published
2017
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39. AB131. Novel green-light KTP laser en bloc enucleation for nonmuscle-invasive bladder cancer: technique and initial clinical experience

Author

He, Dalin, Fan, Jinhai, Wu, Kaijie, Wang, Xinyang, Wu, Dapeng, Li, Lei, Li, Xudong, Liu, Lixia, Cao, Peilong, Cao, Jianwei, and Chang, Luke S.

Subjects
Nonmuscle-invasive bladder cancer (NMIBC), front-firing green-light laser, clinical experience, Abstract Publication Urology
Abstract

Background and purpose The standard procedure for staging and treating nonmuscle-invasive bladder cancer (NMIBC) is still transurethral resection of bladder tumor (TURBT) via a wire loop. However, TURBT is associated with serious disadvantages that facilitate tumor recurrence. Recently, lasers have been explored as treatment tools for bladder tumors. Here, we report a novel tumor en bloc enucleation using a front-firing green-light potassium-titanyl-phosphate laser and its initial clinical application. Patients and methods From March through June 2013, 45 patients with NMIBC received modified transurethral resection using a front-firing green-light laser. En bloc enucleation was performed on all tumors. Preoperative and intraoperative data were retrospectively collected. Results All patients successfully went through a session of treatment with front-firing green-light laser enucleation of the bladder tumor. Complications such as bladder hemorrhage, vesicle perforation, and obturator nerve reflex were not encountered during the treatment. The tumor diameter ranges from 0.3 to 3.0 cm with a mean value of 1.8 cm. Mean operative time and enucleation time were 21 [12-38] and 12 [4-23] minutes, respectively. Serum hemoglobin decreased 1.1 (0.1-2.4) mg/dL averagely. Mean catheter time was 2.0 (1.0-3.0) days, and mean postoperative hospital stay was 2.5 (1.5-4.0) days. The stages of bladder cancer included 27 Ta, 15 T1, and 3 T2a. No tumor recurrence was observed at the initial 6-month follow-up. Conclusions The modified technique using a front-firing green-light laser to en bloc enucleate bladder tumors is effective and safe for treatment of NMIBC. Moreover, it may improve the accurate valuation of tumor stage and prediction of postoperative prognosis, although long-term outcomes and prospective clinical trials are needed.

Published
2014

44. A comparison of NBI and WLI cystoscopy in detecting non-muscle-invasive bladder cancer: A prospective, randomized and multi-center study

Author

Ye, Zhangqun, primary, Hu, Jia, additional, Song, Xiaodong, additional, Li, Fan, additional, Zhao, Xuetao, additional, Chen, Shan, additional, Wang, Xiaofeng, additional, He, Dalin, additional, Fan, Jinhai, additional, Ye, Dingwei, additional, Xing, Jinchun, additional, Pan, Tiejun, additional, and Wang, Dongwen, additional

Published
2015
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47. HIF-1α promotes ZEB1 expression and EMT in a human bladder cancer lung metastasis animal model.

Author

Zhu, Jianning, Huang, Zhixin, Zhang, Mengzhao, Wang, Weiyi, Liang, Hua, Zeng, Jin, Wu, Kaijie, Wang, Xinyang, Hsieh, Jer-Tsong, Guo, Peng, and Fan, Jinhai

Subjects
BLADDER cancer, METASTASIS, LUNG cancer, ANIMAL models in research, SMALL interfering RNA
Abstract

HIF-1 promotes ZEB1 expression and EMT in a human bladder cancer lung metastasis animal model (B) Wound-healing assay to demonstrate that T24-L cells exhibited higher migration activity than T24-P cells, and T24-L control cells exhibited higher migration activity compared with HIF-1 knockdown T24-L cells. HIF-1 , hypoxia inducible factor-1 ; siRNA, small interfering RNA; T24-L,T24 lung metastasis cells; T24-P, T24 parental cells; NC, negative control. [Extracted from the article]

Published
2021
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48. Diagnostic accuracy of cystoscopic biopsy for tumour grade in outpatients with urothelial carcinoma of the bladder and the risk factors of upgrading

Author

Fan, Junjie, Liang, Hua, Fan, Jinhai, Li, Lei, Zhang, Guanjun, Pei, Xinqi, Yang, Tao, He, Dalin, and Wu, Kaijie

Abstract

To assess the concordance of tumour grade in specimens obtained from diagnostic cystoscopic biopsy and transurethral resection of bladder tumour (TURBT) and explore the risk factors of upgrading.

Published
2021
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49. Global, regional, and national levels and trends in burden of urticaria: A systematic analysis for the Global Burden of Disease study 2019.

Author

Pu Y, He L, Wang X, Zhang Y, Zhao S, and Fan J

Subjects
Humans, Male, Female, Adult, Child, Young Adult, Adolescent, Middle Aged, Child, Preschool, Aged, Incidence, Infant, Disability-Adjusted Life Years trends, Prevalence, Infant, Newborn, Global Burden of Disease trends, Global Health statistics & numerical data, Urticaria epidemiology, Cost of Illness
Abstract

Background: Urticaria places a significant burden on individuals and society due to its widespread nature. The aim of this study was to evaluate the burden of urticaria in different regions and nations by analysing data from the Global Burden of Disease study 2019 (GBD 2019), with the goal of providing information to health care policymakers., Methods: By utilising data from the GBD 2019 database, this study analysed metrics such as incidence, prevalence, disability-adjusted life years (DALYs), age-standardised rate (ASR), and estimated annual percentage changes (EAPC) globally and across 204 countries and regions. The data was further stratified by age, sex, and sociodemographic index (SDI)., Results: In 2019, global incidence cases, prevalence cases, and overall disease burden as measured by DALYs all increased. The distribution of the burden exhibited marked geographical heterogeneity. At the regional level, the burden is highest in Central and Eastern Europe and Central Asia, with the strongest growth in South Asia, compared with a decline in the high-income Asia Pacific. At the country level, Nepal reports the highest burden of urticaria, while Portugal has the lowest. Gender and age analyses showed that the burden of urticaria is higher in females than in males, with urticaria cases declining with age, especially in children, and picking up among the elderly. The study also finds a correlation between the burden of urticaria and the SDI, with the central part of the SDI showing a consistent increasing trend., Conclusion: This study found that the global burden of urticaria has risen from 1990 to 2019. Factors like geographic location, gender, and SDI influenced the urticaria burden. Overall, these results offer a resource to guide public health strategies seeking to reduce the burden of urticaria., Competing Interests: Disclosure of interest: The authors completed the ICMJE Disclosure of Interest Form (available upon request from the corresponding author) and disclose no relevant interests., (Copyright © 2024 by the Journal of Global Health. All rights reserved.)

Published
2024
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