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3 results on '"Familial susceptibility"'

1. Kikuchi-Fujimoto Disease in Human Leukocyte Antigen Partially Matched Siblings: A Case Study of Familial Susceptibility.

Author

Isoda A, Tahara K, and Ide M

Abstract

Kikuchi-Fujimoto disease (KFD) is a rare and self-limiting disorder that predominantly affects young individuals of Asian descent. This case report describes familial KFD in partially human leukocyte antigen (HLA)-matched siblings. An adolescent male presented with cervical lymphadenopathy and elevated lactate dehydrogenase (LDH) levels, diagnosed by biopsy as KFD; approximately one year later, his sister presented with similar symptoms. Both siblings were found to carry the HLA-DPB1*0202 allele, which is commonly associated with KFD. These cases highlight a genetic component in KFD and encourage further genetic research to delineate the pathogenesis of the disease., Competing Interests: The authors have declared that no competing interests exist., (Copyright © 2023, Isoda et al.)

Published
2023
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2. Familial aggregation and heritability of Loa loa microfilaremia

Author

Serge Eyebe, Audrey Sabbagh, Michel Boussinesq, Hugues C. Nana-Djeunga, Cédric B. Chesnais, Joseph Kamgno, and Sébastien D Pion

Subjects
Adult, Male, 0301 basic medicine, Microbiology (medical), Adolescent, 030231 tropical medicine, Pedigree chart, heritability, familial susceptibility, Loa, Young Adult, 03 medical and health sciences, Loiasis, 0302 clinical medicine, parasitic diseases, Mansonelliasis, Prevalence, Genetic predisposition, Animals, Humans, Medicine, Genetic Predisposition to Disease, Mansonella perstans, Cameroon, First-degree relatives, Microfilariae, filariasis, Ivermectin, Antiparasitic Agents, biology, Coinfection, business.industry, Family aggregation, Mansonella, Middle Aged, Heritability, loiasis, biology.organism_classification, medicine.disease, 030104 developmental biology, Infectious Diseases, Africa, Female, Loa loa, business, Demography
Abstract

Background. For a given prevalence of Loa loa microfilaremia, the proportion of people with high densities varies significantly between communities. We hypothesized that this variation is related to the existence of familial clusters of hypermicrofilaremic individuals that would be the consequence of a genetic predisposition to present high L. loa microfilarial densities. Methods. A familial study was performed in 10 villages in the Okola Health District of Cameroon. Intrafamilial correlation coefficients and heritability estimates were assessed for both the presence of L. loa microfilaremia and individual microfilarial densities by controlling for age, sex, Mansonella perstans coinfection, and household effects. Results. Pedigrees were constructed for 1126 individuals. A significant familial susceptibility to be microfilaremic for L. loa was found for first-degree relatives (rho = 0.08, P

Published
2018

3. Joint Effects of Environmental Exposures and Familial Susceptibility to Lung Cancer in Chinese Never Smoking Men and Women

Author

Wei Hu, Lap Ah Tse, Bu-Tian Ji, Joseph S. K. Au, Nathaniel Rothman, Xiaorong Wang, Hong Qiu, Ignatius Tak-sun Yu, and Qing Lan

Subjects
Pulmonary and Respiratory Medicine, Male, medicine.medical_specialty, Lung Neoplasms, Meat, Family Cancer History, Interaction, Adenocarcinoma, Risk Assessment, Article, Toxicology, Risk Factors, Smoke, Epidemiology, Familial susceptibility, Vegetables, medicine, Odds Ratio, Humans, Environmental risk factors, Genetic Predisposition to Disease, Cooking, Family history, Lung cancer, business.industry, Odds ratio, Environmental exposure, Environmental Exposure, Vitamins, medicine.disease, Lung neoplasm, Confidence interval, Diet, Oncology, Air Pollution, Indoor, Dietary Supplements, Hong Kong, Female, Gene-Environment Interaction, Risk assessment, business, Demography
Abstract

OBJECTIVES: Previous epidemiological studies had limited power to investigate the joint effects of individual environmental risk factors and familial susceptibility to lung cancer. This study aimed to address this shortcoming. METHODS: We recruited 345 never smoking lung cancer cases and 828 community referents. We developed a collective environmental exposure index by assigning a value of 1 to subjects at high risks regarding environmental risk factors and 0 otherwise, and then summed over using weights equivalent to the excess odds ratio. Potential additive and multiplicative interactions between environmental exposure index and family cancer history were examined. RESULTS: Compared with “low environmental exposure and without family cancer history”, the odds ratio was 6.80 (95% confidence interval = 3.31–13.98) for males who had high environmental exposures but without family cancer history, whereas it increased to 30.61 (95% confidence interval = 9.38–99.87) if they also had a positive family history. The corresponding associations became weaker in never smoking females. No multiplicative interaction was observed for both genders and an additive interaction was restricted among males. CONCLUSIONS: This study developed a novel environmental exposure index that offers sufficient interest deserving further studies on the interactions between environmental exposures and familial susceptibility to lung cancer risk.

Published
2014

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