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1. Haploidentical age-adapted myeloablative transplant and regulatory and effector T cells for acute myeloid leukemia

Author

Pierini, Antonio, Ruggeri, Loredana, Carotti, Alessandra, Falzetti, Franca, Saldi, Simonetta, Terenzi, Adelmo, Zucchetti, Claudio, Ingrosso, Gianluca, Zei, Tiziana, Iacucci Ostini, Roberta, Piccinelli, Sara, Bonato, Samanta, Tricarico, Sara, Mancusi, Antonella, Ciardelli, Sara, Limongello, Roberto, Merluzzi, Mara, Di Ianni, Mauro, Tognellini, Rita, Minelli, Olivia, Mecucci, Cristina, Martelli, Maria Paola, Falini, Brunangelo, Martelli, Massimo Fabrizio, Aristei, Cynthia, and Velardi, Andrea

Published
2021
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3. Clinical-Grade–Expanded Regulatory T Cells Prevent Graft-versus-Host Disease While Allowing a Powerful T Cell–Dependent Graft-versus-Leukemia Effect in Murine Models

Author

Del Papa, Beatrice, Ruggeri, Loredana, Urbani, Elena, Baldoni, Stefano, Cecchini, Debora, Zei, Tiziana, Iacucci Ostini, Roberta, Crescenzi, Barbara, Carotti, Alessandra, Pierini, Antonio, Sportoletti, Paolo, Di Bartolomeo, Paolo, Falzetti, Franca, Mecucci, Cristina, Velardi, Andrea, Martelli, Massimo F., and Di Ianni, Mauro

Published
2017
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8. Tregs prevent GVHD and promote immune reconstitution in HLA-haploidentical transplantation

Author

Di Ianni, Mauro, Falzetti, Franca, Carotti, Alessandra, Terenzi, Adelmo, Castellino, Flora, Bonifacio, Elisabetta, Del Papa, Beatrice, Zei, Tiziana, Ostini, Roberta Iacucci, Cecchini, Debora, Aloisi, Teresa, Perruccio, Katia, Ruggeri, Loredana, Balucani, Chiara, Pierini, Antonio, Sportoletti, Paolo, Aristei, Cynthia, Falini, Brunangelo, Reisner, Yair, Velardi, Andrea, Aversa, Franco, and Martelli, Massimo F.

Published
2011
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9. Novel NPM1 exon 5 mutations and gene fusions leading to aberrant cytoplasmic nucleophosmin in AML

Author

Martelli, Maria Paola, primary, Rossi, Roberta, additional, Venanzi, Alessandra, additional, Meggendorfer, Manja, additional, Perriello, Vincenzo Maria, additional, Martino, Giovanni, additional, Spinelli, Orietta, additional, Ciurnelli, Raffaella, additional, Varasano, Emanuela, additional, Brunetti, Lorenzo, additional, Ascani, Stefano, additional, Quadalti, Corinne, additional, Cardinali, Valeria, additional, Mezzasoma, Federica, additional, Gionfriddo, Ilaria, additional, Milano, Francesca, additional, Pacini, Roberta, additional, Tabarrini, Alessia, additional, Bigerna, Barbara, additional, Albano, Francesco, additional, Specchia, Giorgina, additional, Vetro, Calogero, additional, Di Raimondo, Francesco, additional, Annibali, Ombretta, additional, Avvisati, Giuseppe, additional, Rambaldi, Alessandro, additional, Falzetti, Franca, additional, Tiacci, Enrico, additional, Sportoletti, Paolo, additional, Haferlach, Torsten, additional, Haferlach, Claudia, additional, and Falini, Brunangelo, additional

Published
2021
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10. Dectin-1 Y238X polymorphism associates with susceptibility to invasive aspergillosis in hematopoietic transplantation through impairment of both recipient- and donor-dependent mechanisms of antifungal immunity

Author

Cunha, Cristina, Di Ianni, Mauro, Bozza, Silvia, Giovannini, Gloria, Zagarella, Silvia, Zelante, Teresa, D'Angelo, Carmen, Pierini, Antonio, Pitzurra, Lucia, Falzetti, Franca, Carotti, Alessandra, Perruccio, Katia, Latgé, Jean-Paul, Rodrigues, Fernando, Velardi, Andrea, Aversa, Franco, Romani, Luigina, and Carvalho, Agostinho

Published
2010
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11. CD34+ cells from AML with mutated NPM1 harbor cytoplasmic mutated nucleophosmin and generate leukemia in immunocompromised mice

Author

Martelli, Maria Paola, Pettirossi, Valentina, Thiede, Christian, Bonifacio, Elisabetta, Mezzasoma, Federica, Cecchini, Debora, Pacini, Roberta, Tabarrini, Alessia, Ciurnelli, Raffaella, Gionfriddo, Ilaria, Manes, Nicla, Rossi, Roberta, Giunchi, Linda, Oelschlägel, Uta, Brunetti, Lorenzo, Gemei, Marica, Delia, Mario, Specchia, Giorgina, Liso, Arcangelo, Di Ianni, Mauro, Di Raimondo, Francesco, Falzetti, Franca, Del Vecchio, Luigi, Martelli, Massimo F., and Falini, Brunangelo

Published
2010
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13. Acute GvHD after HLA-Haploidentical Hematopoietic Cell Transplantation with Regulatory and Conventional T Cell Immunotherapy Does Not Adversely Affect Transplantation Outcomes

Author

Bonato, Samanta, primary, Del Sordo, Rachele, additional, Mancusi, Antonella, additional, Terenzi, Adelmo, additional, Zei, Tiziana, additional, Iacucci Ostini, Roberta, additional, Tricarico, Sara, additional, Piccinelli, Sara, additional, Griselli, Mario, additional, Marzuttini, Francesca, additional, Viglione, Valerio, additional, Torti, Eleonora, additional, Sembenico, Rebecca, additional, Limongello, Roberto, additional, Merluzzi, Mara, additional, Hoxha, Eni, additional, Ciardelli, Sara, additional, Sola, Rosaria, additional, Falzetti, Franca, additional, Giansanti, Michele, additional, Martelli, Massimo Fabrizio, additional, Ruggeri, Loredana, additional, Carotti, Alessandra, additional, Velardi, Andrea, additional, and Pierini, Antonio, additional

Published
2021
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15. Clinical-Grade Expanded Regulatory T Cells Are Enriched with Highly Suppressive Cells Producing IL-10, Granzyme B, and IL-35

Author

Ulbar, Francesca, Villanova, Ida, Giancola, Raffaella, Baldoni, Stefano, Guardalupi, Francesco, Fabi, Bianca, Olioso, Paola, Capone, Anita, Sola, Rosaria, Ciardelli, Sara, Del Papa, Beatrice, Brattelli, Antonello, Ricciardi, Ilda, Taricani, Stefano, Sabbatinelli, Giulia, Iuliani, Ornella, Passeri, Cecilia, Sportoletti, Paolo, Santarone, Stella, Pierini, Antonio, Calabrese, Giuseppe, Falzetti, Franca, Bonfini, Tiziana, Accorsi, Patrizia, Ruggeri, Loredana, Martelli, Massimo Fabrizio, Velardi, Andrea, and Di Ianni, Mauro

Published
2020
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16. Bepridil exhibits anti‐leukemic activity associated with NOTCH1 pathway inhibition in chronic lymphocytic leukemia

Author

Baldoni, Stefano, Del Papa, Beatrice, Dorillo, Erica, Aureli, Patrizia, De Falco, Filomena, Rompietti, Chiara, Sorcini, Daniele, Varasano, Emanuela, Cecchini, Debora, Zei, Tiziana, Di Tommaso, Ambra, Rosati, Emanuela, Alexe, Gabriela, Roti, Giovanni, Stegmaier, Kimberly, Di Ianni, Mauro, Falzetti, Franca, and Sportoletti, Paolo

Subjects
Bepridil, Antineoplastic Agents, Apoptosis, Mice, NOTCH1, hemic and lymphatic diseases, Biomarkers, Tumor, Tumor Microenvironment, Animals, Humans, Receptor, Notch1, Cancer Therapy and Prevention, Chemotaxis, Mesenchymal Stem Cells, targeted therapy, Calcium Channel Blockers, Prognosis, Leukemia, Lymphocytic, Chronic, B-Cell, Xenograft Model Antitumor Assays, embryonic structures, Mutation, cardiovascular system, chronic lymphocytic leukemia, sense organs, biological phenomena, cell phenomena, and immunity, Drug Screening Assays, Antitumor
Abstract

Dysregulated NOTCH1 signaling, by either gene mutations or microenvironment interactions, has been increasingly linked to chronic lymphocytic leukemia (CLL). Thus, inhibiting NOTCH1 activity represents a potential therapeutic opportunity for this disease. Using gene expression‐based screening, we identified the calcium channel modulator bepridil as a new NOTCH1 pathway inhibitor. In primary CLL cells, bepridil induced selective apoptosis even in the presence of the protective stroma. Cytotoxic effects of bepridil were independent of NOTCH1 mutation and other prognostic markers. The antitumor efficacy of bepridil was associated with inhibition of NOTCH1 activity through a decrement in trans‐membrane and activated NOTCH1 protein levels with unchanged NOTCH2 protein levels. In a CLL xenotransplant model, bepridil significantly reduced the percentage of leukemic cells infiltrating the spleen via enhanced apoptosis and decreased NOTCH1 activation. In conclusion, we report in vitro and in vivo anti‐leukemic activity of bepridil associated with inhibition of the NOTCH1 pathway in CLL. These data provide a rationale for the clinical development of bepridil as anti‐NOTCH1 targeted therapy for CLL patients., What's new? In search of new inroads against chronic lymphocytic leukemia, these authors turned to the NOTCH1 signalling pathway. Could inhibiting NOTCH1 help treat CLL? To find out, they first identified the calcium channel blocker bepridil as a NOTCH1 inhibitor. Next, they showed that bepredil induced apoptosis in isolated CLL cells, regardless of whether they bore NOTCH1 mutations. In mice bearing CLL cells, bepredil inhibited the proliferation of the tumor cells with no overt signs of toxicity. Thus, it seems advisable to pursue bepredil as a possible candidate for treating CLL.

Published
2018

20. Predictive Factors for Overall Survival in Chronic Myeloid Leukemia Patients: An Analysis By the Gimema Cml Italian Study

Author

Specchia, Giorgina, primary, Pregno, Patrizia, additional, Breccia, Massimo, additional, Monagheddu, Chiara, additional, Castagnetti, Fausto, additional, Bonifacio, Massimiliano, additional, Tiribelli, Mario, additional, Stagno, Fabio, additional, Caocci, Giovanni, additional, Martino, Bruno, additional, Luciano, Luigiana, additional, Pizzuti, Michele, additional, Gozzini, Antonella, additional, Scortechini, Anna Rita, additional, Albano, Francesco, additional, Bergamaschi, Micaela, additional, Capodanno, Isabella, additional, Patriarca, Andrea, additional, Fava, Carmen, additional, Rege Cambrin, Giovanna, additional, Sorà, Federica, additional, Galimberti, Sara, additional, Bocchia, Monica, additional, Binotto, Gianni, additional, Reddiconto, Giovanni, additional, Guarini, Attilio, additional, Maggi, Alessandro, additional, Sanpaolo, Grazia, additional, De Candia, Maria Stella, additional, Giai, Valentina, additional, Abruzzese, Elisabetta, additional, Miggiano, Maria Cristina, additional, Falzetti, Franca, additional, La Barba, Gaetano, additional, Pietrantuono, Giuseppe, additional, Guella, Anna, additional, Levato, Luciano, additional, Mulas, Olga, additional, Saccona, Fabio, additional, Rosti, Gianantonio, additional, Musto, Pellegrino, additional, Di Raimondo, Francesco, additional, Pane, Fabrizio, additional, Foà, Robin, additional, Baccarani, Michele, additional, Ciccone, Giovannino, additional, and Saglio, Giuseppe, additional

Published
2020
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21. Decreased NOTCH1 Activation Correlates with Response to Ibrutinib in Chronic Lymphocytic Leukemia

Author

Del Papa, Beatrice, primary, Baldoni, Stefano, additional, Dorillo, Erica, additional, De Falco, Filomena, additional, Rompietti, Chiara, additional, Cecchini, Debora, additional, Cantelmi, Maria Grazia, additional, Sorcini, Daniele, additional, Nogarotto, Manuel, additional, Adamo, Francesco Maria, additional, Mezzasoma, Federica, additional, Silva Barcelos, Estevão Carlos, additional, Albi, Elisa, additional, Iacucci Ostini, Roberta, additional, Di Tommaso, Ambra, additional, Marra, Andrea, additional, Montanaro, Guido, additional, Martelli, Maria Paola, additional, Falzetti, Franca, additional, Di Ianni, Mauro, additional, Rosati, Emanuela, additional, and Sportoletti, Paolo, additional

Published
2019
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22. The proportion of different BCR-ABL1 transcript types in chronic myeloid leukemia. An international overview

Author

Baccarani, Michele Castagnetti, Fausto Gugliotta, Gabriele and Rosti, Gianantonio Soverini, Simona Albeer, Ali Pfirrmann, Markus Bekadja, Mohamed-Amine Entasoltan, Badra Nachi, Mourad Elghandour, Ashraf El Sorady, Manal Abdelfattah, Raafat El Nahass, Yasser Samra, Mohamed Azzazi, Mohammed and Elsobki, Ezat Moussa, Mohamed Fahmy, Omar Mattar, Mervat and Shehata, Samir Eid Azmy, Emad Bolarinwa, Rahman A. Eid, Samir Khelif, Abderrhaim Hached, Farhat Menif, Samia and Rahman, Hafizur Huang, Xiaojun Jiang, Qian Ye, Yuanxin and Zhu, Huanling Chen, Suning Varma, Neelam Ganesan, Prasanth and Gundeti, Sadashivudu Malhotra, Hemant Radhakrishnan, Vivek S. Kumar, Lalit Sharawat, Surender Kumar Seth, Tulika and Ausekar, B. V. Balasubramanian, Poonkuzhali Poopak, Behzad and Inokuchi, Koiti Kim, Dong-Wook Al Kindi, Salam Mirasol, Angelina Qari, Mohammed Goh, Yeow Tee Shih, Lee-Yung and Branford, Susan Lion, Thomas Valent, Peter Burgstaller, Sonja Thaler, Joseph Labar, Boris Zadro, Renata Mayer, Jiri Zackova, Daniela Faber, Edgar Pallisgaard, Niels and Xavier-Mahon, Francois Lippert, Eric Cayuela, Jean Michel and Rea, Delphine Millot, Frederic Suttorp, Meinolf Hochhaus, Andreas Niederwieser, Dietger Saussele, Susanne Haferlach, Torsten Jeromine, Sabine Panayiotidis, Panayiotis Conneally, Eibhlin Langabeer, Steve Nagler, Arnon Rupoli, Serena and Santoro, Nicola Albano, Francesco Castagnetti, Fausto and Ottaviani, Emanuela Rambaldi, Alessandro Stagno, Fabio and Molica, Stefano Biagiotti, Caterina Scappini, Barbara and Lemoli, Roberto Iurlo, Alessandra Pungolino, Ester Menna, Giuseppe Pane, Fabrizio Gottardi, Enrico Rege-Cambrin, Giovanna Binotto, Gianni Putti, Maria Caterina Falzetti, Franca Visani, Giuseppe Galimberti, Sara Musto, Pellegrino and Abruzzese, Elisabetta Breccia, Massimo Giona, Fiorina and Chiusolo, Patrizia Sica, Simona Fava, Carmen Ferrero, Dario and Tiribelli, Mario Bonifacio, Massimiliano Griskevicius, Laimonas Musteata, Vasile Janssen, Jeroen Prejzner, Witold and Sacha, Tomasz Waclaw, Joanna Almeida, Antonio Medina and Kulikov, Sergei Turkina, Anna Bogdanovic, Andrija Zupan, Irena Marce, Silvia Cervantes, Francisco Steegmann, Juan Luis Kotlyarchuk, Konstyantyn Milner, Benedict J. Rose, Susan Clench, Tim Waits, Paula Austin, Steve Wickham, Caroline Clark, Richard Apperley, Jane Claudiani, Simone and Foroni, Letizia Szydlo, Richard Burt, Emma Bescoby, Ruth and Cork, Leanne O'Brien, Stephen Green, Bethaney Hawtree, Sarah and Watson, Mark Bengio, Raquel Maria Larripa, Irene and Pavlovsky, Carolina Moiraghi, Beatriz Requiao de Pinna, Cristiane Almeida Romani Magalhaes, Gustavo Henrique Pagnano, Katia Funke, Vaneuza Tavares, Renato Sampaio Prado, Adriana and Azevedo, Alita Andrade Fogliatto, Laura Bonecker, Simone and Centrone, Renato Moellman, Artur Conchon, Monika Centurion, Maria Elida Prado, Ana-Ines Lopez, J. L. Petruzziello, Fara and Bendit, Israel Int BCR-ABL Study Grp

Subjects
hemic and lymphatic diseases
Abstract

There are different BCR-ABL1 fusion genes that are translated into proteins that are different from each other, yet all leukemogenic, causing chronic myeloid leukemia (CML) or acute lymphoblastic leukemia. Their frequency has never been systematically investigated. In a series of 45503 newly diagnosed CML patients reported from 45 countries, it was found that the proportion of e13a2 (also known as b2a2) and of e14a2 (also known as b3a2), including the cases co-expressing e14a2 and el 3a2, was 37.9% and 62.1%, respectively. The proportion of these two transcripts was correlated with gender, e13a2 being more frequent in males (39.2%) than in females (36.2%), was correlated with age, decreasing from 39.6% in children and adolescents down to 31.6% in patients >= 80 years old, and was not constant worldwide. Other, rare transcripts were reported in 666/34561 patients (1.93%). The proportion of rare transcripts was associated with gender (2.27% in females and 1.69% in males) and with age (from 1.79% in children and adolescents up to 3.84% in patients >= 80 years old). These data show that the differences in proportion are not by chance. This is important, as the transcript type is a variable that is suspected to be of prognostic importance for response to treatment, outcome of treatment, and rate of treatment-free remission.

Published
2019

23. Outcome of very elderly chronic myeloid leukaemia patients treated with imatinib frontline

Author

Crugnola, Monica, Castagnetti, Fausto, Breccia, Massimo, Ferrero, Dario, Trawinska, Malgorzata Monika, Abruzzese, Elisabetta, Annunziata, Mario, Stagno, Fabio, Tiribelli, Mario, Binotto, Gianni, Bonifacio, Massimiliano, Fava, Carmen, Iurlo, Alessandra, Bucelli, Cristina, Mansueto, Giovanna, Gozzini, Antonella, Falzetti, Franca, Montefusco, Enrico, Crisà, Elena, Gugliotta, Gabriele, Russo, Sabina, Cedrone, Michele, Russorossi, Antonella, Pregno, Patrizia, Isidori, Alessandro, Mauro, Endri, Atelda, Romano, Giglio, Gianfranco, Celesti, Francesca, Sora', Federica, Storti, Sergio, D'Addosio, Adam, Galimberti, Sara, Orlandi, Ester, Calistri, Elisabetta, Bocchia, Monica, Cavazzini, Francesco, Rege Cambrin, Giovanna, Orofino, Nicola, Luciano, Luigiana, Sgherza, Nicola, Rosti, Gianantonio, Latagliata, Roberto, Capodanno, Isabella, Sorà, Federica (ORCID:0000-0002-9607-5298), Storti, Sergio (ORCID:0000-0002-4374-3985), Crugnola, Monica, Castagnetti, Fausto, Breccia, Massimo, Ferrero, Dario, Trawinska, Malgorzata Monika, Abruzzese, Elisabetta, Annunziata, Mario, Stagno, Fabio, Tiribelli, Mario, Binotto, Gianni, Bonifacio, Massimiliano, Fava, Carmen, Iurlo, Alessandra, Bucelli, Cristina, Mansueto, Giovanna, Gozzini, Antonella, Falzetti, Franca, Montefusco, Enrico, Crisà, Elena, Gugliotta, Gabriele, Russo, Sabina, Cedrone, Michele, Russorossi, Antonella, Pregno, Patrizia, Isidori, Alessandro, Mauro, Endri, Atelda, Romano, Giglio, Gianfranco, Celesti, Francesca, Sora', Federica, Storti, Sergio, D'Addosio, Adam, Galimberti, Sara, Orlandi, Ester, Calistri, Elisabetta, Bocchia, Monica, Cavazzini, Francesco, Rege Cambrin, Giovanna, Orofino, Nicola, Luciano, Luigiana, Sgherza, Nicola, Rosti, Gianantonio, Latagliata, Roberto, Capodanno, Isabella, Sorà, Federica (ORCID:0000-0002-9607-5298), and Storti, Sergio (ORCID:0000-0002-4374-3985)

Abstract

PURPOSE: We performed a nationwide registry-based analysis to describe the clinical outcome of adults patients with Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL) who underwent an allogeneic hematopoietic stem cell transplantation (HSCT) after a TKI-based treatment. PATIENTS AND RESULTS: A total of 441 patients were included in the study. The median age at HSCT was 44 years (range 18-70). All the 441 patients (100%) received TKI before the HSCT (performed between 2005 and 2016). Of these patients, 404 (92%) were in cytologic complete remission (CR), while the remaining 37 (8%) had an active disease at the time of HSCT. Molecular minimal residual disease (MRD) was negative in 147 patients (36%) at the time of HSCT. The donor was unrelated in 46% of cases. The prevalent source of stem cells was peripheral blood (70%). The conditioning regimen was myeloablative in 82% of cases (TBI-based in 50%) and included ATG in 51% of cases. With a median follow-up after HSCT of 39.4 months (range: 1-145), the overall survival (OS) probability at 1, 2 and 5 years was 69.6%, 61.1% and 50.3%, respectively, with a median OS of 62 months. Progression-free survival (PFS) at 1, 2 and 5 years was 60.2%, 52.1% and 43.7%, respectively. OS and PFS were significantly better in patients with CR and MRD-negative at the time of transplant compared with those of patients with CR but MRD-positive (50% OS not reached vs. 36 months, P=0.015; 50% PFS not reached vs. 26 months, P=0.003). The subgroup of MRD-negative patients both at HSCT and at 3 months after HSCT had a better outcome (5 years OS rate 70%). Conversely, the 37 patients who underwent a HSCT with active Ph+ ALL had a median OS and PFS of 7 and 5 months, respectively. The 5 years cumulative incidence of relapse was significantly lower in MRD-negative patients (19.5% vs. 35.4%, P=0.001). The non-relapse mortality (NRM) after 1, 2 and 5 years was 19.1% (95%CI: 15.5-22.9), 20.7% (95%CI: 17-24.7) and 24.1% (95%CI: 20

Published
2019

25. Adoptive Immunotherapy with Regulatory and Conventional T Cells in Haploidentical Transplantation Primes Dendritic Cells to Promote T Cell Alloreactivity in the Bone Marrow and Tolerance in the Periphery

Author

Di Ianni, Mauro, primary, Giancola, Raffaella, additional, Baldoni, Stefano, additional, Ulbar, Francesca, additional, Del Papa, Beatrice, additional, Santarone, Stella, additional, Natale, Annalisa, additional, Olioso, Paola, additional, Di Bartolomeo, Paolo, additional, Bonfini, Tiziana, additional, Accorsi, Patrizia, additional, Sportoletti, Paolo, additional, Carotti, Alessandra, additional, Pierini, Antonio, additional, Ruggeri, Loredana, additional, Falzetti, Franca, additional, Martelli, Massimo Fabrizio, additional, and Velardi, Andrea, additional

Published
2019
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26. Preliminary Results of CML1214, a Survey on Ponatinib Compassionate Use in Italy By the Gimema CML Working Party

Author

Fava, Carmen, primary, Dragani, Matteo Emidio, additional, Boggione, Paola, additional, Paoloni, Francesca, additional, Luciano, Luigiana, additional, Gozzini, Antonella, additional, Pregno, Patrizia, additional, Abruzzese, Elisabetta, additional, Gambacorti-Passerini, Carlo, additional, Specchia, Giorgina, additional, Elena, Chiara, additional, Lunghi, Monia, additional, Pungolino, Ester, additional, Falzetti, Franca, additional, Galimberti, Sara, additional, Iurlo, Alessandra, additional, D'Arena, Giovanni, additional, Reddiconto, Giovanni, additional, Fozza, Claudio, additional, Bergamaschi, Micaela, additional, Crea, Enrico, additional, Saglio, Giuseppe, additional, and Rege Cambrin, Giovanna, additional

Published
2019
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27. Activation of Regulatory T Cells with IL-2 and TNF-α to Promote Homing to the Gut and to Improve Acute GvHD Prevention

Author

Mancusi, Antonella, primary, Bonato, Samanta, additional, Del Sordo, Rachele, additional, Piccinelli, Sara, additional, Hoxha, Eni, additional, Zei, Tiziana, additional, Iacucci Ostini, Roberta, additional, Falzetti, Franca, additional, Carotti, Alessandra, additional, Ruggeri, Loredana, additional, Giansanti, Michele, additional, Negrin, Robert S., additional, Martelli, Massimo Fabrizio, additional, Velardi, Andrea, additional, and Pierini, Antonio, additional

Published
2019
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28. Regulatory T Cell Adoptive Immunotherapy Promotes B Cell Immunity after Haploidentical Transplantation

Author

Piccinelli, Sara, primary, Mancusi, Antonella, additional, Hoxha, Eni, additional, Ruggeri, Loredana, additional, Falzetti, Franca, additional, Carotti, Alessandra, additional, Terenzi, Adelmo, additional, Bonato, Samanta, additional, Paradiso, Matteo, additional, Zei, Tiziana, additional, Iacucci Ostini, Roberta, additional, Bigerna, Barbara, additional, Falini, Brunangelo, additional, Di Ianni, Mauro, additional, Martelli, Massimo Fabrizio, additional, Velardi, Andrea, additional, and Pierini, Antonio, additional

Published
2019
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29. Treg/Tcon Immunotherapy and High Dose Marrow Irradiation Ensure Full Control of Leukemia Relapse in Haploidentical Transplantation

Author

Pierini, Antonio, primary, Carotti, Alessandra, additional, Ruggeri, Loredana, additional, Falzetti, Franca, additional, Terenzi, Adelmo, additional, Piccinelli, Sara, additional, Lancellotta, Valentina, additional, Saldi, Simonetta, additional, Minelli, Olivia, additional, Aristei, Cynthia, additional, Martelli, Massimo Fabrizio, additional, and Velardi, Andrea, additional

Published
2019
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30. Chronic Myeloid Leukemia Patient’s Voice About the Experience of Treatment-Free Remission Failure: Results From the Italian Sub-Study of ENESTPath Exploring the Emotional Experience of Patients During Different Phases of a Clinical Trial

Author

Borghi, Lidia, primary, Galimberti, Sara, additional, Baratè, Claudia, additional, Bonifacio, Massimiliano, additional, Capochiani, Enrico, additional, Cuneo, Antonio, additional, Falzetti, Franca, additional, Iurlo, Alessandra, additional, Lunghi, Francesca, additional, Minotto, Claudia, additional, Orlandi, Ester Maria, additional, Rege-Cambrin, Giovanna, additional, Sica, Simona, additional, Supekar, Sharon, additional, Haenig, Jens, additional, and Vegni, Elena, additional

Published
2019
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32. Outcome of Patients with Relapsed/Refractory (R/R) Chronic Lymphocytic Leukemia (CLL) Treated with Ibrutinib within a Named Patient Program (NPP) in Italy. a Real-Life Retrospective Study

Author

Mauro, Francesca Romana, primary, Soddu, Stefano, additional, Frustaci, Annamaria Maria, additional, Orsucci, Lorella, additional, Motta, Marina, additional, Scarfo, Lydia, additional, Zinzani, Pier Luigi, additional, Falzetti, Franca, additional, Farina, Lucia, additional, Marasca, Roberto, additional, Cortelezzi, Agostino, additional, Carlo-Stella, Carmelo, additional, Molica, Stefano, additional, Coscia, Marta, additional, Zaja, Francesco, additional, Laurenti, Luca, additional, de Fabritiis, Paolo, additional, Gaidano, Gianluca, additional, Gobbi, Marco, additional, Tani, Monica, additional, Di Renzo, Nicola, additional, Fazi, Paola, additional, Vignetti, Marco, additional, Cuneo, Antonio, additional, and Foà, Robin, additional

Published
2018
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33. How Adoptive Immunotherapy with Conventional T and Regulatory T Cells Exerts a Gvl Effect without GvHD, after Haploidentical Hematopoietic Transplantation

Author

Ruggeri, Loredana, primary, Carotti, Alessandra, additional, Pierini, Antonio, additional, Falzetti, Franca, additional, Terenzi, Adelmo, additional, Urbani, Elena, additional, Lucia, Amico, additional, Tricarico, Sara, additional, Piccinelli, Sara, additional, Massei, Maria Speranza, additional, Ciardelli, Sara, additional, Di Ianni, Mauro, additional, Zei, Tiziana, additional, Iacucci Ostini, Roberta, additional, Lancellotta, Valentina, additional, Saldi, Simonetta, additional, Minelli, Olivia, additional, Tognellini, Rita, additional, Merluzzi, Mara, additional, Marchesi, Mauro, additional, Caniglia, Maurizio, additional, Aristei, Cynthia, additional, Falini, Brunangelo, additional, Martelli, Massimo Fabrizio, additional, and Velardi, Andrea, additional

Published
2018
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34. Haploidentical Transplantation with Regulatory and Conventional T Cells Improves Outcome of Patients Affected By Acute Myeloid Leukemia with Complex Karyotype and/or Monosomy 7/Del(7q)

Author

Pierini, Antonio, primary, Marra, Andrea, additional, Carotti, Alessandra, additional, Ruggeri, Loredana, additional, Terenzi, Adelmo, additional, Falzetti, Franca, additional, Piccinelli, Sara, additional, Cardinali, Valeria, additional, Mancusi, Antonella, additional, Tardioli, Cecilia, additional, Felicini, Rita, additional, Lucia, Amico, additional, Casarola, Genni, additional, Tricarico, Sara, additional, Bonato, Samanta, additional, Paradiso, Matteo, additional, Griselli, Mario, additional, Crescenzi, Barbara, additional, La Starza, Roberta, additional, Mecucci, Cristina, additional, Falini, Brunangelo, additional, Martelli, Massimo Fabrizio, additional, Martelli, Maria Paola, additional, and Velardi, Andrea, additional

Published
2018
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35. Tocilizumab to Prevent Infusion-Related Events in Patients with Chronic Lymphocytic Leukemia and Co-Morbidities Treated with Obinutuzumab and Chlorambucil: Results from the Randomized Phase Ib GALACTA Trial

Author

Freeman, Ciara Louise, primary, Böttcher, Sebastian, additional, De la Serna, Javier, additional, Delgado, Julio, additional, Falzetti, Franca, additional, Gobbi, Marco, additional, Lejniece, Sandra, additional, Di Bernardo, Maria Chiara, additional, Mallalieu, Navita L, additional, Nielsen, Tina, additional, Knapp, Andrea, additional, and Gribben, John G., additional

Published
2018
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36. Chronic Myeloid Leukemia Italian Multicenter Observational Study (CML-IT-MOS): Clinical Characteristics of Chronic Myeloid Leukemia (CML) Patients Treated in Real-Life between 2012 and 2016 in 66 Italian Hematology Centers of the Gimema Study Group

Author

Specchia, Giorgina, primary, Pregno, Patrizia, additional, Nicolosi, Maura, additional, Castagnetti, Fausto, additional, Martino, Bruno, additional, Breccia, Massimo, additional, Bonifacio, Massimiliano, additional, Stagno, Fabio, additional, Gozzini, Antonella, additional, Tiribelli, Mario, additional, Bergamaschi, Micaela, additional, Pizzuti, Michele, additional, Caocci, Giovanni, additional, Luciano, Luigia, additional, Leoni, Pietro, additional, Guella, Anna, additional, Falzetti, Franca, additional, Di Lorenzo, Roberto, additional, Saccona, Fabio, additional, Monagheddu, Chiara, additional, Albano, Francesco, additional, Pane, Fabrizio, additional, Ciccone, Giovannino, additional, Baccarani, Michele, additional, and Saglio, Giuseppe, additional

Published
2018
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37. Compound BCR-ABL1 Kinase Domain Mutants: Prevalence, Spectrum and Correlation with Tyrosine Kinase Inhibitor Resistance in a Prospective Series of Philadelphia Chromosome-Positive Leukemia Patients Analyzed By Next Generation Sequencing

Author

Soverini, Simona, primary, Bavaro, Luana, additional, Martelli, Margherita, additional, De Benedittis, Caterina, additional, Iurlo, Alessandra, additional, Orofino, Nicola, additional, Pagano, Livio, additional, Criscuolo, Marianna, additional, Bonifacio, Massimiliano, additional, Scaffidi, Luigi, additional, Sica, Simona, additional, Sorà, Federica, additional, Maino, Elena, additional, Rondoni, Michela, additional, Laginestra, Maria Antonella, additional, Lunghi, Francesca, additional, Ermacora, Anna, additional, D'adda, Mariella, additional, Gugliotta, Gabriele, additional, Castagnetti, Fausto, additional, Rosti, Gianantonio, additional, Papayannidis, Cristina, additional, Marconi, Giovanni, additional, Curti, Antonio, additional, Miggiano, Maria Cristina, additional, Galimberti, Sara, additional, Percesepe, Antonio, additional, Stagno, Fabio, additional, Sancetta, Rosaria, additional, Annunziata, Mario, additional, Falzetti, Franca, additional, Capodanno, Isabella, additional, Pregno, Patrizia, additional, Maffioli, Margherita, additional, Intermesoli, Tamara, additional, Di Bona, Eros, additional, Caocci, Giovanni, additional, Attolico, Imma, additional, Binotto, Gianni, additional, Bocchia, Monica, additional, Angelucci, Emanuele, additional, Sgherza, Nicola, additional, Luciano, Luigiana, additional, Mignone, Flavio, additional, Pileri, Stefano A., additional, Martinelli, Giovanni, additional, and Cavo, Michele, additional

Published
2018
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38. NOTCH and Graft-Versus-Host Disease

Author

Di Ianni, Mauro, primary, Del Papa, Beatrice, additional, Baldoni, Stefano, additional, Di Tommaso, Ambra, additional, Fabi, Bianca, additional, Rosati, Emanuela, additional, Natale, Annalisa, additional, Santarone, Stella, additional, Olioso, Paola, additional, Papalinetti, Gabriele, additional, Giancola, Raffaella, additional, Accorsi, Patrizia, additional, Di Bartolomeo, Paolo, additional, Sportoletti, Paolo, additional, and Falzetti, Franca, additional

Published
2018
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39. NOTCH1 Aberrations in Chronic Lymphocytic Leukemia

Author

Rosati, Emanuela, primary, Baldoni, Stefano, additional, De Falco, Filomena, additional, Del Papa, Beatrice, additional, Dorillo, Erica, additional, Rompietti, Chiara, additional, Albi, Elisa, additional, Falzetti, Franca, additional, Di Ianni, Mauro, additional, and Sportoletti, Paolo, additional

Published
2018
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40. NOTCH1 Is Aberrantly Activated in Chronic Lymphocytic Leukemia Hematopoietic Stem Cells

Author

Di Ianni, Mauro, primary, Baldoni, Stefano, additional, Del Papa, Beatrice, additional, Aureli, Patrizia, additional, Dorillo, Erica, additional, De Falco, Filomena, additional, Albi, Elisa, additional, Varasano, Emanuela, additional, Di Tommaso, Ambra, additional, Giancola, Raffaella, additional, Accorsi, Patrizia, additional, Rotta, Gianluca, additional, Rompietti, Chiara, additional, Silva Barcelos, Estevão Carlos, additional, Campese, Antonio Francesco, additional, Di Bartolomeo, Paolo, additional, Screpanti, Isabella, additional, Rosati, Emanuela, additional, Falzetti, Franca, additional, and Sportoletti, Paolo, additional

Published
2018
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41. Cytogenetic/mutation profile of chronic lymphocytic leukemia/malignant melanoma collision tumors of the skin

Author

La Starza, Roberta, primary, Pierini, Tiziana, additional, Pastorino, Lorenza, additional, Albi, Elisa, additional, Matteucci, Caterina, additional, Crescenzi, Barbara, additional, Sportoletti, Paolo, additional, Covarelli, Piero, additional, Falzetti, Franca, additional, Roti, Giovanni, additional, Ascani, Stefano, additional, and Mecucci, Cristina, additional

Published
2018
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43. Additional file 2: Table S1. of MYB deregulation from a EWSR1-MYB fusion at leukemic evolution of a JAK2 V617F positive primary myelofibrosis

Author

Pierini, Tiziana, Danika Di Giacomo, Pierini, Valentina, Gorello, Paolo, Barba, Gianluca, Anair Lema Fernandez, Pellanera, Fabrizia, Iannotti, Tamara, Falzetti, Franca, Starza, Roberta La, and Mecucci, Cristina

Abstract

FISH clones for chromosome 6 long arm breakpoint characterization. Table S2. FISH clones for chromosome 22 long arm telomeric breakpoint characterization. Table S3. FISH clones for chromosome 9 long arm breakpoint characterization. Table S4. Genes, amplicons and primers for mutational analysis. (DOC 991Â kb)

Published
2016
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44. Additional file 3: Figure S1. of MYB deregulation from a EWSR1-MYB fusion at leukemic evolution of a JAK2 V617F positive primary myelofibrosis

Author

Pierini, Tiziana, Danika Di Giacomo, Pierini, Valentina, Gorello, Paolo, Barba, Gianluca, Anair Lema Fernandez, Pellanera, Fabrizia, Iannotti, Tamara, Falzetti, Franca, Starza, Roberta La, and Mecucci, Cristina

Abstract

Multi-FISH analysis showed a complex rearrangement between chromosomes 6, 9 and 22 (yellow arrows). Figure S2. A) Chromosome 6q23 breakpoint within MYB. B) Chromosome 22q11.2 breakpoint within EWSR1. Figure S3. A) SNPa findings at PMF diagnosis: no CNV with 100 and 50 Kb filters (left panel) but LOH at 12q (right panel, black arrow). B) SNPa findings at leukemic transformation: a genomic loss, at 22q11.2, was identified with a 50 Kb filter (left panel, red arrow); LOH at 12q (right panel, red arrow). (DOC 3447Â kb)

Published
2016
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45. The Combination of Rituximab and Bendamustine as First-Line Treatment Is Highly Effective in the Eradicating Minimal Residual Disease in Follicular Lymphoma: An Italian Retrospective Study

Author

Galimberti, Sara, primary, Ciabatti, Elena, additional, Ercolano, Giacomo, additional, Grassi, Susanna, additional, Guerrini, Francesca, additional, Cecconi, Nadia, additional, Rousseau, Martina, additional, Cervetti, Giulia, additional, Mazziotta, Francesco, additional, Iovino, Lorenzo, additional, Falzetti, Franca, additional, Falcinelli, Flavio, additional, Bosi, Alberto, additional, Rigacci, Luigi, additional, Kovalchuk, Sofia, additional, Vallisa, Daniele, additional, Macchia, Lucia, additional, Ciancia, Eugenio, additional, and Petrini, Mario, additional

Published
2017
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46. Chemotherapy-Based HLA Haploidentical Transplantation with Treg/Tcon Immunotherapy in Unfit/Elderly Leukemia Patients: Powerful Gvl Effect and Insights from Animal Models

Author

Ruggeri, Loredana, primary, Carotti, Alessandra, additional, Falzetti, Franca, additional, Diianni, Mauro, additional, Pierini, Antonio, additional, Massei, Maria Speranza, additional, Amico, Lucia, additional, Piccinelli, Sara, additional, Urbani, Elena, additional, Martelli, Massimo Fabrizio, additional, and Velardi, Andrea, additional

Published
2016
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47. Identification and Characterization of Novel Rare Nucleophosmin (NPM1) Gene Mutations in Acute Myeloid Leukemia (AML) By a Combinatorial Approach of Immunohistochemistry and Molecular Analyses

Author

Martelli, Maria Paola, primary, Rossi, Roberta, additional, Varasano, Emanuela, additional, Specchia, Giorgina, additional, Di Raimondo, Francesco, additional, Avvisati, Giuseppe, additional, Tiacci, Enrico, additional, Falzetti, Franca, additional, Sportoletti, Paolo, additional, and Falini, Brunangelo, additional

Published
2016
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48. ENESTPath: A Phase 3 Study to Assess the Effect of Nilotinib Treatment Duration on Treatment-Free Remission (TFR) in Patients with Chronic Myeloid Leukemia in Chronic Phase (CML-CP) Previously Treated with Imatinib: 24-Month Analysis of the First 300 Patients in the Induction/Consolidation Phase

Author

Rea, Delphine, primary, Rosti, Gianantonio, additional, Cross, Nicholas CP, additional, Hellmann, Andrzej, additional, Niederwieser, Dietger, additional, Pungolino, Ester, additional, Falzetti, Franca, additional, Pregno, Patrizia, additional, Orlandi, Ester Maria, additional, Almeida, Antonio, additional, Illes, Arpad, additional, Sagues, Miguel, additional, Haenig, Jens, additional, Supekar, Sharon, additional, Shah, Seema, additional, Saglio, Giuseppe, additional, Steegmann, Juan Luis, additional, and Baccarani, Michele, additional

Published
2016
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49. Imatinib and polypharmacy in very old patients with chronic myeloid leukemia: Effects on response rate, toxicity and outcome

Author

Iurlo, Alessandra, Nobili, Alessandro, Latagliata, Roberto, Bucelli, Cristina, Castagnetti, Fausto, Breccia, Massimo, Abruzzese, Elisabetta, Cattaneo, Daniele, Fava, Carmen, Ferrero, Dario, Gozzini, Antonella, Bonifacio, Massimiliano, Tiribelli, Mario, Pregno, Patrizia, Stagno, Fabio, Vigneri, Paolo, Annunziata, Mario, Cavazzini, Francesco, Binotto, Gianni, Mansueto, Giovanna Rosaria, Russo, Sabina, Falzetti, Franca, Montefusco, Enrico, Gugliotta, Gabriele, Storti, Sergio, D'Addosio, Ada M., Scaffidi, Luigi, Cortesi, Laura, Cedrone, Michele, Rossi, Antonella Russo, Avanzini, Paolo, Mauro, Endri, Spadea, Antonio, Celesti, Francesca, Giglio, Gianfranco, Isidori, Alessandro, Crugnola, Monica, Calistri, Elisabetta, Sora', Federica, Rege Cambrin, Giovanna, Sica, Simona, Luciano, Luigiana, Galimberti, Sara, Orlandi, Ester M., Bocchia, Monica, Tettamanti, Mauro, Alimena, Giuliana, Saglio, Giuseppe, Rosti, Gianantonio, Mannucci, Pier Mannuccio, Cortelezzi, Agostino, Storti, Sergio (ORCID:0000-0002-4374-3985), Sora', Federica (ORCID:0000-0002-9607-5298), Sica, Simona (ORCID:0000-0003-2426-3465), Iurlo, Alessandra, Nobili, Alessandro, Latagliata, Roberto, Bucelli, Cristina, Castagnetti, Fausto, Breccia, Massimo, Abruzzese, Elisabetta, Cattaneo, Daniele, Fava, Carmen, Ferrero, Dario, Gozzini, Antonella, Bonifacio, Massimiliano, Tiribelli, Mario, Pregno, Patrizia, Stagno, Fabio, Vigneri, Paolo, Annunziata, Mario, Cavazzini, Francesco, Binotto, Gianni, Mansueto, Giovanna Rosaria, Russo, Sabina, Falzetti, Franca, Montefusco, Enrico, Gugliotta, Gabriele, Storti, Sergio, D'Addosio, Ada M., Scaffidi, Luigi, Cortesi, Laura, Cedrone, Michele, Rossi, Antonella Russo, Avanzini, Paolo, Mauro, Endri, Spadea, Antonio, Celesti, Francesca, Giglio, Gianfranco, Isidori, Alessandro, Crugnola, Monica, Calistri, Elisabetta, Sora', Federica, Rege Cambrin, Giovanna, Sica, Simona, Luciano, Luigiana, Galimberti, Sara, Orlandi, Ester M., Bocchia, Monica, Tettamanti, Mauro, Alimena, Giuliana, Saglio, Giuseppe, Rosti, Gianantonio, Mannucci, Pier Mannuccio, Cortelezzi, Agostino, Storti, Sergio (ORCID:0000-0002-4374-3985), Sora', Federica (ORCID:0000-0002-9607-5298), and Sica, Simona (ORCID:0000-0003-2426-3465)

Abstract

Background: About 40% of all patients with chronic myeloid leukemia are currently old or very old. They are effectively treated with imatinib, even though underrepresented in clinical studies. Furthermore, as it happens in the general population, they often receive multiple drugs for associated chronic illnesses. Aim of this study was to assess whether or not in imatinib-treated patients aged > 75 years the exposure to polypharmacy (5 drugs or more) had an impact on cytogenetic and molecular response rates, event-free and overall survival, as well as on hematological or extra-hematological toxicity. Methods: 296 patients at 35 Italian hematological institutions were evaluated. Results: Polypharmacy was reported in 107 patients (36.1%), and drugs more frequently used were antiplatelets, diuretics, proton pump inhibitors, ACE-inhibitors, beta-blockers, calcium channel blockers, angiotensin II receptors blockers, statins, oral hypoglycemic drugs and alpha blockers. Complete cytogenetic response was obtained in 174 patients (58.8%), 78 (26.4%) within 6 month, 63 (21.3%) between 7 and 12 months. Major molecular response was obtained in 153 patients (51.7%), 64 (21.6%) within the 12 month. One hundred and twenty-eight cases (43.2%) of hematological toxicity were recorded, together with 167 cases (56.4%) of extra-hematological toxicity. Comparing patients exposed to polypharmacy to those without, no difference was observed pertaining to the dosage of imatinib, cytogenetic and molecular responses and hematological and extra-hematological toxicity. Conclusion: Notwithstanding the several interactions reported in the literature between imatinib and some of the medications considered herewith, this fact does not seem to have a clinical impact on response rate and outcome.

Published
2016

50. Personal history and quality of life in chronic myeloid leukemia patients: a cross-sectional study using narrative medicine and quantitative analysis

Author

Breccia, Massimo, Graffigna, Guendalina, Galimberti, Sara, Iurlo, Alessandra, Pungolino, Ester, Pizzuti, Michele, Maggi, Alessandro, Falzetti, Franca, Capalbo, Silvana Franca, Intermesoli, Tamara, Maffioli, Margherita, Elena, Chiara, Melosi, Alessandro, Simonetti, Federico, Capochiani, Enrico, Seta, Roberta Della, Pacilli, Matteo, Luppi, Mario, Di Renzo, Nicola, Mastrullo, Lucia, Trabacchi, Elena, Vallisa, Daniele, Rapezzi, Davide, Orlandi, Ester Maria, Gambacorti Passerini, Carlo, Efficace, Fabio, Alimena, Giuliana, Graffigna, Guendalina (ORCID:0000-0003-4378-7467), Breccia, Massimo, Graffigna, Guendalina, Galimberti, Sara, Iurlo, Alessandra, Pungolino, Ester, Pizzuti, Michele, Maggi, Alessandro, Falzetti, Franca, Capalbo, Silvana Franca, Intermesoli, Tamara, Maffioli, Margherita, Elena, Chiara, Melosi, Alessandro, Simonetti, Federico, Capochiani, Enrico, Seta, Roberta Della, Pacilli, Matteo, Luppi, Mario, Di Renzo, Nicola, Mastrullo, Lucia, Trabacchi, Elena, Vallisa, Daniele, Rapezzi, Davide, Orlandi, Ester Maria, Gambacorti Passerini, Carlo, Efficace, Fabio, Alimena, Giuliana, and Graffigna, Guendalina (ORCID:0000-0003-4378-7467)

Abstract

BACKGROUND: Tyrosine kinase inhibitors (TKIs) drastically changed the outcome of patients diagnosed with chronic myeloid leukemia (CML). Several reports indicated the advantage of continue long-term adherence associated with positive outcome. Therefore, it is important to better understand from the patient's standpoint the experience of living with the disease and the related treatment. OBJECTIVES: In this study, quantitative analysis and narrative medicine were combined to get insights on this issue in a population of 257 patients with CML in chronic phase treated with TKIs (43% men, with a median age of 58years, 27% aged 31-50years), followed for a median time of 5years. Sixty-one percent of patients enrolled were treated in first line, whereas 37% were treated in second line. RESULTS: The results showed more positive perceptions and acceptance in males compared to females, without impact of disease on relationships. Level of positive acceptance was more evident in elderly compared to younger patients, with a close connection with median time from diagnosis. Overall, female patients reported negative perceptions and an impact of disease on family daily living. The majority of patients understood the importance of continue adherence to treatment, with 27% resulting less adherent (60% for forgetfulness), even if well informed and supported by his/her physician. DISCUSSION AND CONCLUSIONS: Narrative medicine, in association to quantitative analysis, can help physicians to understand needs of their patients in order to improve communication.

Published
2016

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