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2. Mental impact of Covid-19 among Spanish healthcare workers. A large longitudinal survey.

Author

Alonso, J., Vilagut, G., Alayo, I., Ferrer, M., Amigo, F., Aragón-Peña, A., Aragonès, E., Campos, M., del Cura-González, I., Urreta, I., Espuga, M., González Pinto, A., Haro, J. M., López Fresneña, N., Martínez de Salázar, A., Molina, J. D., Ortí Lucas, R. M., Parellada, M., Pelayo-Terán, J. M., and Pérez Zapata, A.

Subjects
MEDICAL personnel, COVID-19 pandemic, ALCOHOLISM, COVID-19, MENTAL illness, LOGISTIC regression analysis
Abstract

Aims: Longitudinal data on the mental health impact of the coronavirus disease 2019 (Covid-19) pandemic in healthcare workers is limited. We estimated prevalence, incidence and persistence of probable mental disorders in a cohort of Spanish healthcare workers (Covid-19 waves 1 and 2) -and identified associated risk factors. Methods: 8996 healthcare workers evaluated on 5 May–7 September 2020 (baseline) were invited to a second web-based survey (October–December 2020). Major depressive disorder (PHQ-8 ≥ 10), generalised anxiety disorder (GAD-7 ≥ 10), panic attacks, post-traumatic stress disorder (PCL-5 ≥ 7), and alcohol use disorder (CAGE-AID ≥ 2) were assessed. Distal (pre-pandemic) and proximal (pandemic) risk factors were included. We estimated the incidence of probable mental disorders (among those without disorders at baseline) and persistence (among those with disorders at baseline). Logistic regression of individual-level [odds ratios (OR)] and population-level (population attributable risk proportions) associations were estimated, adjusting by all distal risk factors, health care centre and time of baseline interview. Results: 4809 healthcare workers participated at four months follow-up (cooperation rate = 65.7%; mean = 120 days s.d. = 22 days from baseline assessment). Follow-up prevalence of any disorder was 41.5%, (v. 45.4% at baseline, p < 0.001); incidence, 19.7% (s.e. = 1.6) and persistence, 67.7% (s.e. = 2.3). Proximal factors showing significant bivariate-adjusted associations with incidence included: work-related factors [prioritising Covid-19 patients (OR = 1.62)], stress factors [personal health-related stress (OR = 1.61)], interpersonal stress (OR = 1.53) and financial factors [significant income loss (OR = 1.37)]. Risk factors associated with persistence were largely similar. Conclusions: Our study indicates that the prevalence of probable mental disorders among Spanish healthcare workers during the second wave of the Covid-19 pandemic was similarly high to that after the first wave. This was in good part due to the persistence of mental disorders detected at the baseline, but with a relevant incidence of about 1 in 5 of HCWs without mental disorders during the first wave of the Covid-19 pandemic. Health-related factors, work-related factors and interpersonal stress are important risks of persistence of mental disorders and of incidence of mental disorders. Adequately addressing these factors might have prevented a considerable amount of mental health impact of the pandemic among this vulnerable population. Addressing health-related stress, work-related factors and interpersonal stress might reduce the prevalence of these disorders substantially. Study registration number: NCT04556565 [ABSTRACT FROM AUTHOR]

Published
2022
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3. The addition of fermented milk with plant sterols improves the adherence to lifestyle changes in hypercholesterolemic patients. The RECIPE study

Author

Masana L., Lagares M., Pinto X., Reinares L., Zuniga M., Descamps O., Bosi E., Allaert F. A., Chapman J., Bruckert E., Hernandez T., Martin C., Gomes H., Perez P. J., Gil E. M., Moro A., Jorda M. D., Lopez J. L., Alba M., Bilbao I., Alustiza M. R., Aliaga M., Munoz J. G., Terol A. M., Gomez P., Marcos M. A., Gonzalez M., Rodriguez M. J., Lopez M. V., Romero M. A., Puyo N., Egido J. F., Monreal I., Ramirez A., Madariaga M. A., De Miguel M. C., Lorda A., Munoz G., Moreno I. M., Martinez A., Sanchez A., Espino A., Gonzalez. F. J., Pracht C., Ocana C., Pena M. A., Domingo C., Gilaberte M. T., Garcia C., Diez J. A., Fornes F. V., Gutierrez M. D., Macarra E., Bugella J. I., Del. J. M., Bravo A., Becerra M. J., Carbonell C., De Miguel M., Perez A., Martin A., Romero J., Gonzalez P., Iglesias A., Lopez B., Villalonga G., Carvajal P., Marin C., Cardona F., Gonzalez A., Fernandez G., Gomez D., Sanchez C. L., Viveros D., De Lucas M. G., Marin J. M., Osorno J., Pumares C., Gimenez R., Latorre J., Barreiro M. C., Villanueva J. R., Lopez J. A., Balaguer I., Baron J., Espuga M., Firas R., Trias F., Moran A., Velasco V., Vazquez F., Hernando A., Manzanares A., Abad J. L., Peraferrer M., Obarrio A., Alonso M. L., Gomez L., Roca J., Ayus B. E., Urban F., Gonzalez E., Masegosa C., Barrilero E., Jimenez M. C., Carratala M. M., Petitbo D., Ferrandiz J., Mialdea M. J., Montoro J., Muncharaz M. E., Shehchar A., De Paula L., Cano A., Sanchez L., Perez J., Alarcon C., Martinez J. F., Garrido T., Martinez F., Gomariz I., Caparros M., Kseibi T., Palomo L., Jimenez T., Luque I., Villar P., Gonzalez J. J., Aparicio J., Jimenez O., Munoz J. J., Baez F., Marcos M. P., Gonzalez T., Estevez J. A., Garcia J., Ajuria-Gogeasko S., Cabrera M., Manzano J. M., Segura G., Abat X., Yanovsky N., Borrachero J. M., Fortuny M., Martinez M. D., Gutierrez A. R., Najem N., Romero M. C., Martin S., Valverde R. J., Molina C., Martinez B., Izquierdo L., Vazquez I., Martinez M. T., Mateos A., Quiles F., Aranda F. J., Iborra R., Valero A. B., Fornes M. T., Quinza V., Colado F., Arribas B., Martinez J. E. L., Garces M. P., Valero J. M., Frigola J. L., Rubio J. M., Gongora A., Triana J., Gomez C., Garcia M. L., Diez C., Pombo G., Gutierrez M. C., Nazara C. A., De Oca M. A., Maquieira N., Pilo A., Buenadicha J. L., Duran F., Pena J. E., Navarro S., Serrano F. J., Sanchez S., Mesa S., Salazar J. A., De La Escosura A., Perez F., Solera J., Tarraga P., Ramos L., Gutierrez J. A., Caldelas S., Albinana F., Lopez J. F., Florian J., Rocha E., Rodriguez J., Mellado M. L., Calvillo M. R., Cruz T., Capitan M., Diaz J., Tome J., Prieto A., Tome V., Caro M., Montero A., Ontoria M., Garcia D. L., Gil F., De Zarate V., Casaponsa J., Matamala J., Salvande A., Trueba M. A., Cidra J. L., Garcia A., Toro A., Berna J. R., Zornoza B., Prieto M. T., Garcia L., Lopez C., Garcia P., Echegaray M. C., Navarro B., Moro M. L., Herrero A., Tamargo C., Perez S. J., Antero E., Penacho M. C., Blanco Y., Lucena J., Sisto C. A., Salido E., Dolz F., Granja J. M., Saavedra F., Sanchez-Oro I., Mas-Magro F., Artundo T., Fernandez A., Vaquer J. V., Aso K., Palacios A., Morante J. L., Seller T., Vendrell J. M., Masana, L., Lagares, M., Pinto, X., Reinares, L., Zuniga, M., Descamps, O., Bosi, E., Allaert, F. A., Chapman, J., Bruckert, E., Hernandez, T., Martin, C., Gomes, H., Perez, P. J., Gil, E. M., Moro, A., Jorda, M. D., Lopez, J. L., Alba, M., Bilbao, I., Alustiza, M. R., Aliaga, M., Munoz, J. G., Terol, A. M., Gomez, P., Marcos, M. A., Gonzalez, M., Rodriguez, M. J., Lopez, M. V., Romero, M. A., Puyo, N., Egido, J. F., Monreal, I., Ramirez, A., Madariaga, M. A., De Miguel, M. C., Lorda, A., Munoz, G., Moreno, I. M., Martinez, A., Sanchez, A., Espino, A., Gonzale, z. F. J., Pracht, C., Ocana, C., Pena, M. A., Domingo, C., Gilaberte, M. T., Garcia, C., Diez, J. A., Fornes, F. V., Gutierrez, M. D., Macarra, E., Bugella, J. I., De, l. J. M., Bravo, A., Becerra, M. J., Carbonell, C., De Miguel, M., Perez, A., Martin, A., Romero, J., Gonzalez, P., Iglesias, A., Lopez, B., Villalonga, G., Carvajal, P., Marin, C., Cardona, F., Gonzalez, A., Fernandez, G., Gomez, D., Sanchez, C. L., Viveros, D., De Lucas, M. G., Marin, J. M., Osorno, J., Pumares, C., Gimenez, R., Latorre, J., Barreiro, M. C., Villanueva, J. R., Lopez, J. A., Balaguer, I., Baron, J., Espuga, M., Firas, R., Trias, F., Moran, A., Velasco, V., Vazquez, F., Hernando, A., Manzanares, A., Abad, J. L., Peraferrer, M., Obarrio, A., Alonso, M. L., Gomez, L., Roca, J., Ayus, B. E., Urban, F., Gonzalez, E., Masegosa, C., Barrilero, E., Jimenez, M. C., Carratala, M. M., Petitbo, D., Ferrandiz, J., Mialdea, M. J., Montoro, J., Muncharaz, M. E., Shehchar, A., De Paula, L., Cano, A., Sanchez, L., Perez, J., Alarcon, C., Martinez, J. F., Garrido, T., Martinez, F., Gomariz, I., Caparros, M., Kseibi, T., Palomo, L., Jimenez, T., Luque, I., Villar, P., Gonzalez, J. J., Aparicio, J., Jimenez, O., Munoz, J. J., Baez, F., Marcos, M. P., Gonzalez, T., Estevez, J. A., Garcia, J., Ajuria-Gogeasko, S., Cabrera, M., Manzano, J. M., Segura, G., Abat, X., Yanovsky, N., Borrachero, J. M., Fortuny, M., Martinez, M. D., Gutierrez, A. R., Najem, N., Romero, M. C., Martin, S., Valverde, R. J., Molina, C., Martinez, B., Izquierdo, L., Vazquez, I., Martinez, M. T., Mateos, A., Quiles, F., Aranda, F. J., Iborra, R., Valero, A. B., Fornes, M. T., Quinza, V., Colado, F., Arribas, B., Martinez, J. E. L., Garces, M. P., Valero, J. M., Frigola, J. L., Rubio, J. M., Gongora, A., Triana, J., Gomez, C., Garcia, M. L., Diez, C., Pombo, G., Gutierrez, M. C., Nazara, C. A., De Oca, M. A., Maquieira, N., Pilo, A., Buenadicha, J. L., Duran, F., Pena, J. E., Navarro, S., Serrano, F. J., Sanchez, S., Mesa, S., Salazar, J. A., De La Escosura, A., Perez, F., Solera, J., Tarraga, P., Ramos, L., Gutierrez, J. A., Caldelas, S., Albinana, F., Lopez, J. F., Florian, J., Rocha, E., Rodriguez, J., Mellado, M. L., Calvillo, M. R., Cruz, T., Capitan, M., Diaz, J., Tome, J., Prieto, A., Tome, V., Caro, M., Montero, A., Ontoria, M., Garcia, D. L., Gil, F., De Zarate, V., Casaponsa, J., Matamala, J., Salvande, A., Trueba, M. A., Cidra, J. L., Garcia, A., Toro, A., Berna, J. R., Zornoza, B., Prieto, M. T., Garcia, L., Lopez, C., Garcia, P., Echegaray, M. C., Navarro, B., Moro, M. L., Herrero, A., Tamargo, C., Perez, S. J., Antero, E., Penacho, M. C., Blanco, Y., Lucena, J., Sisto, C. A., Salido, E., Dolz, F., Granja, J. M., Saavedra, F., Sanchez-Oro, I., Mas-Magro, F., Artundo, T., Fernandez, A., Vaquer, J. V., Aso, K., Palacios, A., Morante, J. L., Seller, T., and Vendrell, J. M.

Subjects
Hypercholesterolemia, Phytosterol, Fermented milk, Lifestyle, Diet
Abstract

Introduction: RECIPE study was designed to assess the impact of dietary supplementation with fermented milk enriched with plant sterols (FMPS) on the nutritional behavior, lifestyle and the joint therapeutic responsibility of hypercholesterolemic patients. Methods: Observational, prospective, multicenter, international study, was conducted to assess dietary habits and other lifestyle components in hypercholesterolemic patients in whom the general practitioner indicated FMPS supplementation. Nutritional, lifestyle and clinical data were collected at the initial visit and after a 4 months follow-up. The biochemical and anthropometric data were retrieved from medical records obtained at baseline and 4 months. Results: We report the results of Spain. Two hundred and one physicians who provided valid data of 1044 patients participated. The addition of FMPS was associated with improved overall nutritional index, being adequate initially in 28.2% of patients, and increasing up to 75.2% at the end of the study (P< 001). This nutritional change was associated with an improvement in the lipid profile and anthropometric data. Patients more adherent to therapy generally achieved a better result in all parameters compared to non-compliant ones. Conclusions: The addition of FMPS to a diet designed to reduce the LDL enhances the patient's attitude regarding changes in lifestyle, leading to better overall control of dyslipidemia and anthropometric improvement. © 2012 Elsevier España, S.L. and SEA.

Published
2012

4. Traumatic stress symptoms among Spanish healthcare workers during the COVID-19 pandemic: a prospective study.

Author

Portillo-Van Diest A, Vilagut G, Alayo I, Ferrer M, Amigo F, Amann BL, Aragón-Peña A, Aragonès E, Asúnsolo Del Barco Á, Campos M, Del Cura-González I, Espuga M, González-Pinto A, Haro JM, Larrauri A, López-Fresneña N, Martínez de Salázar A, Molina JD, Ortí-Lucas RM, Parellada M, Pelayo-Terán JM, Pérez-Zapata A, Pijoan JI, Plana N, Puig T, Rius C, Rodríguez-Blázquez C, Sanz F, Serra C, Urreta-Barallobre I, Kessler RC, Bruffaerts R, Vieta E, Pérez-Solá V, Alonso J, and Mortier P

Subjects
Humans, Prospective Studies, Pandemics, Poly(ADP-ribose) Polymerase Inhibitors, Health Personnel, Depression, COVID-19 epidemiology, Stress Disorders, Post-Traumatic epidemiology
Abstract

Aim: To investigate the occurrence of traumatic stress symptoms (TSS) among healthcare workers active during the COVID-19 pandemic and to obtain insight as to which pandemic-related stressful experiences are associated with onset and persistence of traumatic stress., Methods: This is a multicenter prospective cohort study. Spanish healthcare workers ( N  = 4,809) participated at an initial assessment (i.e., just after the first wave of the Spain COVID-19 pandemic) and at a 4-month follow-up assessment using web-based surveys. Logistic regression investigated associations of 19 pandemic-related stressful experiences across four domains (infection-related, work-related, health-related and financial) with TSS prevalence, incidence and persistence, including simulations of population attributable risk proportions (PARP)., Results: Thirty-day TSS prevalence at T1 was 22.1%. Four-month incidence and persistence were 11.6% and 54.2%, respectively. Auxiliary nurses had highest rates of TSS prevalence (35.1%) and incidence (16.1%). All 19 pandemic-related stressful experiences under study were associated with TSS prevalence or incidence, especially experiences from the domains of health-related (PARP range 88.4-95.6%) and work-related stressful experiences (PARP range 76.8-86.5%). Nine stressful experiences were also associated with TSS persistence, of which having patient(s) in care who died from COVID-19 had the strongest association. This association remained significant after adjusting for co-occurring depression and anxiety., Conclusions: TSSs among Spanish healthcare workers active during the COVID-19 pandemic are common and associated with various pandemic-related stressful experiences. Future research should investigate if these stressful experiences represent truly traumatic experiences and carry risk for the development of post-traumatic stress disorder.

Published
2023
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