Search

Your search keyword '"Enninga, Elizabeth A. L."' showing total 29 results
Start Over Author "Enninga, Elizabeth A. L." Search Limiters Full Text
29 results on '"Enninga, Elizabeth A. L."'

3. Single cell profiling at the maternal–fetal interface reveals a deficiency of PD-L1+ non-immune cells in human spontaneous preterm labor

Author

Liu, Xiao, Aneas, Ivy, Sakabe, Noboru, Anderson, Rebecca L., Billstrand, Christine, Paz, Cristina, Kaur, Harjot, Furner, Brian, Choi, Seong, Prichina, Adriana Y., Enninga, Elizabeth Ann L., Dong, Haidong, Murtha, Amy, Crawford, Gregory E., Kessler, John A., Grobman, William, Nobrega, Marcelo A., Rana, Sarosh, and Ober, Carole

Published
2023
Full Text
View/download PDF

5. Maternal SARS-CoV-2 infection in pregnancy disrupts gene expression in Hofbauer cells with limited impact on cytotrophoblasts

Author

Enninga, Elizabeth Ann L., primary, Quach, Huy Quang, additional, Jang, Jin Sung, additional, de Araujo Correia, Maria Cristina Miranda, additional, Fedyshyn, Yaroslav, additional, Fedyshyn, Bohdana, additional, Lemens, Maureen, additional, Littlefield, Dawn, additional, Behl, Supriya, additional, Sintim-Aboagye, Elise, additional, Mejia Plazas, Maria C., additional, Cardenas, Maria C., additional, Chakraborty, Shree, additional, Yamaoka, Satoko, additional, Ebihara, Hideki, additional, Pandey, Akhilesh, additional, Li, Hu, additional, Badley, Andrew D., additional, Johnson, Erica L., additional, Sun, Jie, additional, Norgan, Andrew P., additional, Theiler, Regan N., additional, and Chakraborty, Rana, additional

Published
2024
Full Text
View/download PDF

8. Prevention of the Vertical Transmission of HIV; A Recap of the Journey so Far

Author

Cardenas, Maria Camila, primary, Farnan, Sheila, additional, Hamel, Benjamin L., additional, Mejia Plazas, Maria Camila, additional, Sintim-Aboagye, Elise, additional, Littlefield, Dawn R., additional, Behl, Supriya, additional, Punia, Sohan, additional, Enninga, Elizabeth Ann L, additional, Johnson, Erica, additional, Temesgen, Zelalem, additional, Theiler, Regan, additional, Gray, Clive M., additional, and Chakraborty, Rana, additional

Published
2023
Full Text
View/download PDF

10. Single cell profiling at the maternal–fetal interface reveals a deficiency of PD-L1+ non-immune cells in human spontaneous preterm labor.

Author

Liu, Xiao, Aneas, Ivy, Sakabe, Noboru, Anderson, Rebecca L., Billstrand, Christine, Paz, Cristina, Kaur, Harjot, Furner, Brian, Choi, Seong, Prichina, Adriana Y., Enninga, Elizabeth Ann L., Dong, Haidong, Murtha, Amy, Crawford, Gregory E., Kessler, John A., Grobman, William, Nobrega, Marcelo A., Rana, Sarosh, and Ober, Carole

Subjects
PREMATURE labor, DECIDUA, PROGRAMMED cell death 1 receptors, TROPHOBLAST, MATERNAL-fetal exchange, BIRTH rate, PERINATAL death, CELL populations, GENE expression
Abstract

The mechanisms that underlie the timing of labor in humans are largely unknown. In most pregnancies, labor is initiated at term (≥ 37 weeks gestation), but in a signifiicant number of women spontaneous labor occurs preterm and is associated with increased perinatal mortality and morbidity. The objective of this study was to characterize the cells at the maternal–fetal interface (MFI) in term and preterm pregnancies in both the laboring and non-laboring state in Black women, who have among the highest preterm birth rates in the U.S. Using mass cytometry to obtain high-dimensional single-cell resolution, we identified 31 cell populations at the MFI, including 25 immune cell types and six non-immune cell types. Among the immune cells, maternal PD1+ CD8 T cell subsets were less abundant in term laboring compared to term non-laboring women. Among the non-immune cells, PD-L1+ maternal (stromal) and fetal (extravillous trophoblast) cells were less abundant in preterm laboring compared to term laboring women. Consistent with these observations, the expression of CD274, the gene encoding PD-L1, was significantly depressed and less responsive to fetal signaling molecules in cultured mesenchymal stromal cells from the decidua of preterm compared to term women. Overall, these results suggest that the PD1/PD-L1 pathway at the MFI may perturb the delicate balance between immune tolerance and rejection and contribute to the onset of spontaneous preterm labor. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

11. Host-Viral Interactions at the Maternal-Fetal Interface. What We Know and What We Need to Know

Author

Girsch, James H., primary, Mejia Plazas, Maria C., additional, Olivier, Amanda, additional, Farah, Mohamed, additional, Littlefield, Dawn, additional, Behl, Supriya, additional, Punia, Sohan, additional, Sakemura, Reona, additional, Hemsath, Jack R., additional, Norgan, Andrew, additional, Enninga, Elizabeth A. L., additional, Johnson, Erica L., additional, and Chakraborty, Rana, additional

Published
2022
Full Text
View/download PDF

12. Lymphocytic Choriomeningitis Virus Infection Demonstrates Higher Replicative Capacity and Decreased Antiviral Response in the First-Trimester Placenta

Author

Enninga, Elizabeth Ann L. and Theiler, Regan N.

Subjects
lcsh:Immunologic diseases. Allergy, Permissiveness, Article Subject, Placenta, Pregnancy Trimester, Third, viruses, Immunology, Cell Culture Techniques, chemical and pharmacologic phenomena, Context (language use), Lymphocytic Choriomeningitis, Biology, Virus Replication, Lymphocytic choriomeningitis, Virus, 03 medical and health sciences, 0302 clinical medicine, Pregnancy, medicine, Humans, Lymphocytic choriomeningitis virus, Immunology and Allergy, 030212 general & internal medicine, Cells, Cultured, 030304 developmental biology, 0303 health sciences, Fetus, Innate immune system, Interferon-alpha, virus diseases, General Medicine, medicine.disease, Immunity, Innate, 3. Good health, Pregnancy Trimester, First, medicine.anatomical_structure, Chorionic villi, Female, Cytokine secretion, lcsh:RC581-607, Research Article
Abstract

Lymphocytic choriomeningitis virus (LCMV) is a rodent disease that can be transmitted to humans. A majority of persons infected with LCMV have only minor symptoms; however, it can cross the placental barrier during pregnancy and cause congenital defects in the fetus. Some viral infections early in gestation are hypothesized to lead to worse outcomes compared to those acquired during late gestation; however, LCMV has not been studied in this context. In the present study, differences in immunomodulation between the first- and third-trimester placental explants infected with LCMV were measured. LCMV replication was observed in the first-trimester chorionic villi, but not in term. The term placenta exhibited a robust innate immune response to infection by LCMV, marked by induction of ifn-α, il-6, and tnf-α gene expression which was not seen in the first-trimester explants. Cytokine secretion was also only seen in term explants. The results indicate that the first-trimester and term placentas differ in their permissiveness for LCMV infection, inversely correlating with the innate antiviral responses. This has implications for developing effective mechanisms that protect the fetus from infection based on stage of development.

Published
2019

19. Therapeutic plasma exchange clears circulating soluble PD-L1 and PD-L1-positive extracellular vesicles

Author

Orme, Jacob J, primary, Enninga, Elizabeth Ann L, additional, Lucien-Matteoni, Fabrice, additional, Dale, Heather, additional, Burgstaler, Edwin, additional, Harrington, Susan M, additional, Ball, Matthew K, additional, Mansfield, Aaron S, additional, Park, Sean S, additional, Block, Mathew S, additional, Markovic, Svetomir N, additional, Yan, Yiyi, additional, Dong, Haidong, additional, Dronca, Roxana S, additional, and Winters, Jeffrey L, additional

Published
2020
Full Text
View/download PDF

20. SARS-CoV-2 Infection and COVID-19 During Pregnancy: A Multidisciplinary Review

Author

Narang, Kavita, primary, Enninga, Elizabeth Ann L., additional, Gunaratne, Madugodaralalage D.S.K., additional, Ibirogba, Eniola R., additional, Trad, Ayssa Teles A., additional, Elrefaei, Amro, additional, Theiler, Regan N., additional, Ruano, Rodrigo, additional, Szymanski, Linda M., additional, Chakraborty, Rana, additional, and Garovic, Vesna D., additional

Published
2020
Full Text
View/download PDF

22. CD206-positive myeloid cells bind galectin-9 and promote a tumor-supportive microenvironment

Author

Enninga, Elizabeth Ann L., Chatzopoulos, Kyriakos, Butterfield, John T., Sutor, Shari L., Leontovich, Alexey A., Nevala, Wendy K., Flotte, Thomas J., and Markovic, Svetomir N.

Subjects
Adult, Male, animal structures, Skin Neoplasms, THP-1 Cells, Galectins, Receptors, Cell Surface, Article, Young Adult, otorhinolaryngologic diseases, Tumor Microenvironment, Humans, Lectins, C-Type, Melanoma, Chemokine CCL2, Aged, Cell Proliferation, Aged, 80 and over, Chemokine CCL22, integumentary system, Neovascularization, Pathologic, Macrophages, Middle Aged, stomatognathic diseases, Mannose-Binding Lectins, Phenotype, Female, Fibroblast Growth Factor 2, Mannose Receptor, Protein Binding, Signal Transduction
Abstract

In patients with metastatic melanoma, high blood levels of galectin-9 are correlated with worse overall survival and a bias towards a Th2 inflammatory state supportive of tumor growth. Although galectin-9 signaling through TIM3 on T cells has been described, less is known about the interaction of galectin-9 with macrophages. We aimed to determine whether galectin-9 is a binding partner of CD206 on macrophages and whether the result of this interaction is tumor-supportive. It was determined that incubation of CD68+ macrophages with galectin-9 or anti-CD206 blocked target binding and that both CD206 and galectin-9 were detected by immunoprecipitation of cell lysates. CD206 and galectin-9 had a binding affinity of 280 nM. Galectin-9 causes CD206+ macrophages to make significantly more FGF2 and monocyte chemoattractant protein (MCP-1), but less macrophage-derived chemokine (MDC). Galectin-9 had no effect on classical monocyte subsets, but caused expansion of the non-classical populations. Lastly, there was a positive correlation between increasing numbers of CD206 macrophages and galectin-9 expression in tumors, and high levels of CD206 macrophages correlated negatively with melanoma survival. These results indicate that galectin-9 binds CD206 on M2 macrophages, which appear to drive angiogenesis and the production of chemokines that support tumor growth and poor patient prognoses. Targeting this interaction systemically through circulating monocytes may therefore be a novel way to improve local anti-tumor effects by macrophages.

Published
2018

24. Sex Differences in Tolerability to Anti-Programmed Cell Death Protein 1 Therapy in Patients with Metastatic Melanoma and Non-Small Cell Lung Cancer: Are We All Equal?

Author

Duma, Narjust, primary, Abdel-Ghani, Azzouqa, additional, Yadav, Siddhartha, additional, Hoversten, Katherine P., additional, Reed, Clay T., additional, Sitek, Andrea N., additional, Enninga, Elizabeth Ann L., additional, Paludo, Jonas, additional, Aguilera, Jesus Vera, additional, Leventakos, Konstantinos, additional, Lou, Yanyan, additional, Kottschade, Lisa A., additional, Dong, Haidong, additional, Mansfield, Aaron S., additional, Manochakian, Rami, additional, Adjei, Alex A., additional, and Dronca, Roxana S., additional

Published
2019
Full Text
View/download PDF

26. Survival of cutaneous melanoma based on sex, age, and stage in the United States, 1992-2011

Author

Enninga, Elizabeth Ann L., primary, Moser, Justin C., additional, Weaver, Amy L., additional, Markovic, Svetomir N., additional, Brewer, Jerry D., additional, Leontovich, Alexey A., additional, Hieken, Tina J., additional, Shuster, Lynne, additional, Kottschade, Lisa A., additional, Olariu, Ariadna, additional, Mansfield, Aaron S., additional, and Dronca, Roxana S., additional

Published
2017
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results