Search

Your search keyword '"Endres G"' showing total 34 results
Start Over Author "Endres G" Search Limiters Full Text
34 results on '"Endres G"'

3. On a New Cannabinoid Classification System: A Sight on the Illegal Market of Novel Psychoactive Substances

Author

Shevyrin, V., Melkozerov, V., Endres, G. W., Shafran, Y., and Morzherin, Y.

Subjects
INDOLE 3 CARBOXYLATE, CYCLOALKANECARBONYLINDOLE, UNCLASSIFIED DRUG, CLASSIFICATION, DRUG CLASSIFICATION, 3 NAPHTHOYLPYRROLE, INDAZOLE 3 CARBOXYLATE, NAPHTHOYLINDOLE, ENDOCANNABINOID, DRUG TRAFFIC, PHENYLACETYLINDOLE, INDAZOLE DERIVATIVE, INDOLE 3 CARBOXAMIDE, BENZOYLINDOLE, PYRROLE DERIVATIVE, REVIEW, DIARYLPYRAZOLE, 3 CARBONYLINDOLE, DRUG STRUCTURE, PRIORITY JOURNAL, NAPHTHYLMETHYLINDENE, 3 CARBONYLINDAZOLE, STRUCTURE ANALYSIS, ADAMANTANECARBONYLINDOLE, 2 NAPHTHOYLBENZIMIDAZOLE, 2 CARBONYLBENZIMIDAZOLE, SYNTHETIC CANNABINOIDS, DRUG SYNTHESIS, NEW PSYCHOACTIVE SUBSTANCES, INDOLE DERIVATIVE, PYRAZOLE DERIVATIVE, BENZIMIDAZOLE DERIVATIVE, CANNABINOID, BIOLOGICAL ACTIVITY, DRUG ABUSE, INDAZOLE 3 CARBOXAMIDE, INDENE DERIVATIVE, NAPHTHOYLINDAZOLE, ICOSANOID
Abstract

Synthetic cannabinoids are one of the most rapidly expanding classes of novel psychoactive substances found in illegal markets. These substances have evolved to the point that many examples no longer fit with the traditional cannabinoid classification system, where assignment of these compounds is difficult and ambiguous, leading to inconsistencies in regard to their chemical structures. This and other drawbacks can result in misunderstandings between forensic scientists and legal disciplines, complicating efforts toward improving the inadequacies of current antidrug laws. After a critical review, we offer an updated yet simplified cannabinoid classification system with the intention to facilitate interdisciplinary communication. © Vadim Shevyrin et al. 2016; Published by Mary Ann Liebert, Inc. 2016.

Published
2016

5. Stratification of Cannabinoid 1 Receptor (CB1R) Agonist Efficacy: Manipulation of CB1R Density through Use of Transgenic Mice Reveals Congruence between In Vivo and In Vitro Assays

Author

Grim, T. W., primary, Morales, A. J., additional, Gonek, M. M., additional, Wiley, J. L., additional, Thomas, B. F., additional, Endres, G. W., additional, Sim-Selley, L. J., additional, Selley, D. E., additional, Negus, S. S., additional, and Lichtman, A. H., additional

Published
2016
Full Text
View/download PDF

6. Versuche über die Verwendung von Benzoesäure und Natriumbenzoat als Zusatz zu Frischwürsten und zu frisch gehacktem Fleisch: Ausgeführt im Württembergischen Tierärztlichen Landesuntersuchungsamte zu Stuttgart (Vorstand: Geheimrat, Ministerialrat Prof. Dr. von Ostertag), Chemischen Untersuchungsamte der Stadt Stuttgart (Vorstand: Direktor Dr. O. Mezger), Öffentlichen chemischen und bakteriologischen Laboratorium Dr. Schmiedel und Gunzert zu Stuttgart (Inhaber: Dr. R. Schmiedel und Dr. G. Endres)

Author

Eichler, H., Endres, G., Gminder, G., Mezger, O., and Umbrecht, J.

Published
1929
Full Text
View/download PDF

9. Neuere Arbeiten über seltene Metalle

Author

Gravestein, H., Behrens, H., Kley, P. D. C., Moser, L., Brukl, A., Ato, S., Porter, L. E., Browning, Ph. E., Dennis, L. M., Bridgman, J. A., Papish, J., Hoag, L. E., Keil, W., Siegmann, F., Luckmann, H., Meyer, Julius, Renz, C., Brunck, O., Thiel, A., Geer, W. C., Koelsch, H., Mathers, F. C., Bray, U. B., Kirschman, H. D., Kollock, L. G., Smith, E. F., Ostwald, Wilhelm, St. Soule, Baubigny, H., Ehrlich, J., Freed, S., Selwood, P. W., Hopkins, B. S., Autié, G., Job, A., Knorre, G. v., Biltz, W., Pieper, H., Metzger, F. J., Barbieri, G. A., Stěrba-Boehm, J., Matula, V., Tomiček, O., Someya, K., Sarver, L. A., Brinton, P. H. M. P., Aufrecht, A., Ley, H., Rimbach, E., Schubert, A., Delauney, E., Ball, R. W., Yntema, L. F., Prandtl, W., Endres, G., Meyer, R. J., Bodländer, E., Kleinheksel, J. H., Kremers, H. C., Wöhler, L., Grünzwig, M., Katz, S. H., James, C., Lösch, J., Geilmann, W., Brünger, K., Formánek, J., Lundegårdh, H., Buchanan, G. H., Abrahams, H. J., Müller, J. H., Truchot, P., Scott, S. E., Pugh, W., and Wood, J. K.

Published
1933
Full Text
View/download PDF

11. Impact of Sclerotinia Stem Rot on Yield of Canola

Author

del Río, L. E., primary, Bradley, C. A., additional, Henson, R. A., additional, Endres, G. J., additional, Hanson, B. K., additional, McKay, K., additional, Halvorson, M., additional, Porter, P. M., additional, Le Gare, D. G., additional, and Lamey, H. A., additional

Published
2007
Full Text
View/download PDF

27. Part three World airline directory.

Author

Kemp, Rachel, Moore, Linda, Malcher, Kelley, Mountford, Trevor, Tacoun, Fabrice, and Endres, G&uumlnter

Subjects
AIRLINE industry
Abstract

Presents a list of airlines operating scheduled services or those offering significant charter services, including Malaysia Airlines, Northwest Airlines, Southwest Airlines and Sichuan Airlines.

Published
2005

34. Apparent CB 1 Receptor Rimonabant Affinity Estimates: Combination with THC and Synthetic Cannabinoids in the Mouse In Vivo Triad Model.

Author

Grim TW, Morales AJ, Thomas BF, Wiley JL, Endres GW, Negus SS, and Lichtman AH

Subjects
Animals, Cannabinoid Receptor Agonists administration & dosage, Cannabinoid Receptor Antagonists administration & dosage, Cannabinoids administration & dosage, Dose-Response Relationship, Drug, Dronabinol administration & dosage, Drug Combinations, Female, Male, Mice, Mice, Inbred C57BL, Mice, Transgenic, Piperidines administration & dosage, Pyrazoles administration & dosage, Receptor, Cannabinoid, CB1 agonists, Receptor, Cannabinoid, CB1 antagonists & inhibitors, Rimonabant, Cannabinoid Receptor Agonists metabolism, Cannabinoid Receptor Antagonists metabolism, Cannabinoids metabolism, Dronabinol metabolism, Piperidines metabolism, Pyrazoles metabolism, Receptor, Cannabinoid, CB1 metabolism
Abstract

Synthetic cannabinoids (SCs) represent an emerging class of abused drugs associated with psychiatric complications and other substantial health risks. These ligands are largely sold over the internet for human consumption, presumably because of their high cannabinoid 1 receptor (CB 1 R) affinity and their potency in eliciting pharmacological effects similar to Δ 9 -tetrahydrocannabinol (THC), as well as circumventing laws illegalizing this plant. Factors potentially contributing to the increased prevalence of SC abuse and related hospitalizations, such as increased CB 1 R efficacy and non-CB 1 R targets, highlight the need for quantitative pharmacological analyses to determine receptor mediation of the pharmacological effects of cannabinoids. Accordingly, the present study used pA 2 and pK B analyses for quantitative determination of CB 1 R mediation in which we utilized the CB 1 R-selective inverse agonist/antagonist rimonabant to elicit rightward shifts in the dose-response curves of five SCs (i.e., A-834,735D; WIN55,212-2; CP55,950; JWH-073; and CP47,497) and THC in producing common cannabimimetic effects (i.e., catalepsy, antinociception, and hypothermia). The results revealed overall similarity of pA 2 and pK B values for these compounds and suggest that CB 1 Rs, and not other pharmacological targets, largely mediated the central pharmacological effects of SCs. More generally, affinity estimation offers a powerful pharmacological approach to assess potential receptor heterogeneity subserving in vivo pharmacological effects of SCs., (Copyright © 2017 by The American Society for Pharmacology and Experimental Therapeutics.)

Published
2017
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results