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8. S1561 Mycobacterium celatum: A New Pathogen of the Pancreas

Author

Rohit Agrawal, Edward Villa, Jeffrey Rebhun, Sarang Thaker, Constantine Melitas, James Yang, and Elie Ghoulam

Subjects
medicine.anatomical_structure, Hepatology, biology, business.industry, Gastroenterology, medicine, Mycobacterium celatum, Pancreas, business, biology.organism_classification, Pathogen, Microbiology
Published
2021
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9. Su1570 UTILITY OF THE 3-CHROMOSOME FISH TEST IN THE EVALUATION OF INDETERMINATE BILIARY STRICTURES: A SINGLE TERTIARY CENTER EXPERIENCE

Author

Soumojit Ghosh, Ahmad Al-Taee, Samuel Burton, Samer Alkaade, and Elie Ghoulam

Subjects
medicine.medical_specialty, Chromosome (genetic algorithm), business.industry, Internal medicine, Gastroenterology, %22">Fish , Medicine, Radiology, Nuclear Medicine and imaging, Center (algebra and category theory), business, Indeterminate, Test (assessment)
Published
2020
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17. Anastrozole-induced Autoimmune Hepatitis: A Rare Complication of Breast Cancer Therapy

Author

Oleksandra Klapko, Shriram Jakate, Lydia Usha, Sheila Eswaran, and Elie Ghoulam

Subjects
Cancer Research, medicine.medical_specialty, Anti-nuclear antibody, Biopsy, Anastrozole, Breast Neoplasms, Autoimmune hepatitis, Gastroenterology, 03 medical and health sciences, 0302 clinical medicine, Breast cancer, Internal medicine, Nitriles, medicine, Humans, Adverse effect, Aged, Neoplasm Staging, medicine.diagnostic_test, Aromatase Inhibitors, business.industry, Autoantibody, General Medicine, Triazoles, medicine.disease, Hepatitis, Autoimmune, Liver, Oncology, 030220 oncology & carcinogenesis, Liver biopsy, Female, business, Complication, 030217 neurology & neurosurgery, medicine.drug
Abstract

Background Autoimmune hepatitis (AIH) is an extremely rare complication of anastrozole therapy. It presents with elevated liver function tests. The diagnosis is established by detecting high titers of autoantibodies such as antinuclear antibodies, anti-smooth muscle antibodies, and elevated immunoglobulins. It is confirmed with a liver biopsy showing interface rosetting and an increased number of plasma cells. Early diagnosis of anastrozole-induced AIH is important because it allows anastrozole to be discontinued and immunomodulatory treatment to be promptly initiated. Case report We present the case of a 71-year-old female patient diagnosed with early-stage breast cancer. The patient developed AIH as a result of treatment with anastrozole. Its clinicopathological presentation, diagnosis, and treatment are reviewed. Conclusion This case report intends to make clinicians aware of this rare complication of anastrozole therapy. AIH should be suspected in any patient on anastrozole (and possibly, other aromatase inhibitors) who develops elevated liver function tests.

Published
2017
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