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12 results on '"El Khawanky, Nadia"'

1. ROCK1/2 signaling contributes to corticosteroid-refractory acute graft-versus-host disease

Author

Maas-Bauer, Kristina, Stell, Anna-Verena, Yan, Kai-Li, de Vega, Enrique, Vinnakota, Janaki Manoja, Unger, Susanne, Núñez, Nicolas, Norona, Johana, Talvard-Balland, Nana, Koßmann, Stefanie, Schwan, Carsten, Miething, Cornelius, Martens, Uta S., Shoumariyeh, Khalid, Nestor, Rosa P., Duquesne, Sandra, Hanke, Kathrin, Rackiewicz, Michal, Hu, Zehan, El Khawanky, Nadia, Taromi, Sanaz, Andrlova, Hana, Faraidun, Hemin, Walter, Stefanie, Pfeifer, Dietmar, Follo, Marie, Waldschmidt, Johannes, Melchinger, Wolfgang, Rassner, Michael, Wehr, Claudia, Schmitt-Graeff, Annette, Halbach, Sebastian, Liao, James, Häcker, Georg, Brummer, Tilman, Dengjel, Joern, Andrieux, Geoffroy, Grosse, Robert, Tugues, Sonia, Blazar, Bruce R., Becher, Burkhard, Boerries, Melanie, and Zeiser, Robert

Published
2024
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3. Demethylating therapy increases anti-CD123 CAR T cell cytotoxicity against acute myeloid leukemia

Author

El Khawanky, Nadia, Hughes, Amy, Yu, Wenbo, Myburgh, Renier, Matschulla, Tony, Taromi, Sanaz, Aumann, Konrad, Clarson, Jade, Vinnakota, Janaki Manoja, Shoumariyeh, Khalid, Miething, Cornelius, Lopez, Angel F., Brown, Michael P., Duyster, Justus, Hein, Lutz, Manz, Markus G., Hughes, Timothy P., White, Deborah L., Yong, Agnes S. M., and Zeiser, Robert

Published
2021
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5. The clinical spectrum and immunopathological mechanisms underlying ZIKV-induced neurological manifestations

Author

Filgueiras, Igor Salerno, primary, Torrentes de Carvalho, Amanda, additional, Cunha, Daniela Prado, additional, Mathias da Fonseca, Dennyson Leandro, additional, El Khawanky, Nadia, additional, Freire, Paula Paccielli, additional, Cabral-Miranda, Gustavo, additional, Schimke, Lena F., additional, Camara, Niels Olsen Saraiva, additional, Ochs, Hans D., additional, Peron, Jean Pierre Schatzmann, additional, Cabral-Marques, Otávio, additional, and de Vasconcelos, Zilton Farias Meira, additional

Published
2021
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6. Immune-Effector-Cell-Associated-Neurotoxicity-Syndrome (ICANS) Pathophysiology Is Mediated By Microglia TGF-β-Activated Kinase-1 Signaling

Author

Vinnakota, Janaki Manoja, Biavasco, Francesca, Schwabenland, Marius, Chhatbar, Chintan, Adams, Rachael C, Erny, Daniel, Duquesne, Sandra, El Khawanky, Nadia, Salié, Henrike, Athanassopoulos, Dimitrios, Braun, Lukas, Schmidt, Dominik, Fetsch, Viktor, Javorniczky, Rebeka N., Ho, Jenny N.H.G, Marks, Reinhard, Wäsch, Ralph, Simonetta, Federico, Andrieux, Geoffroy, Pfeifer, Dietmar, Monaco, Gianni, Capitini, Christian, Fry, Terry J., Blank, Thomas, Blazar, Bruce R, Wagner Drouet, Eva-Maria, Theobald, Matthias, Sommer, Clemens, Stelljes, Matthias, Reicherts, Christian, Jeibmann, Astrid, Schittenhelm, Jens, Monoranu, Camelia-Maria, Rosenwald, Andreas, Kortüm, K. Martin, Rasche, Leo, Einsele, Hermann, Meyer, Philipp Tobias, Brumberg, Joachim, Mackensen, Andreas, von Bergwelt-Baildon, Michael, Coras, Roland, Albert, Nathalie L., Bartos, Laura M., Brendel, Matthias, Holzgreve, Adrien, Boerries, Melanie, Mackall, Crystal L., Duyster, Justus, Koehler, Natalie, Strübing, Felix, Bengsch, Bertram, Ruella, Marco, Subklewe, Marion, Baumgarten, Louisa von, Gill, Saar, Prinz, Marco, and Zeiser, Robert

Published
2023
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8. The relationship between cytokine and neutrophil gene network distinguishes SARS-CoV-2–infected patients by sex and age

Author

Freire, Paula P., primary, Marques, Alexandre H.C., additional, Baiocchi, Gabriela C., additional, Schimke, Lena F., additional, Fonseca, Dennyson L.M., additional, Salgado, Ranieri C., additional, Filgueiras, Igor S., additional, Napoleao, Sarah M.S., additional, Plaça, Desirée R., additional, Akashi, Karen T., additional, Hirata, Thiago Dominguez Crespo, additional, El Khawanky, Nadia, additional, Giil, Lasse M., additional, Cabral-Miranda, Gustavo, additional, Carvalho, Robson F., additional, Ferreira, Luis Carlos S., additional, Condino-Neto, Antonio, additional, Nakaya, Helder I., additional, Jurisica, Igor, additional, Ochs, Hans D., additional, Camara, Niels Olsen Saraiva, additional, Calich, Vera Lúcia G., additional, and Cabral-Marques, Otavio, additional

Published
2021
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9. Graft-versus-host disease of the CNS is mediated by TNF upregulation in microglia

Author

Mathew, Nimitha R., primary, Vinnakota, Janaki M., additional, Apostolova, Petya, additional, Erny, Daniel, additional, Hamarsheh, Shaimaa, additional, Andrieux, Geoffroy, additional, Kim, Jung-Seok, additional, Hanke, Kathrin, additional, Goldmann, Tobias, additional, Chappell-Maor, Louise, additional, El-Khawanky, Nadia, additional, Ihorst, Gabriele, additional, Schmidt, Dominik, additional, Duyster, Justus, additional, Finke, Jürgen, additional, Blank, Thomas, additional, Boerries, Melanie, additional, Blazar, Bruce R., additional, Jung, Steffen, additional, Prinz, Marco, additional, and Zeiser, Robert, additional

Published
2020
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10. Flow Cytometry Contributions for the Diagnosis and Immunopathological Characterization of Primary Immunodeficiency Diseases With Immune Dysregulation

Author

Cabral-Marques, Otavio, primary, Schimke, Lena F., additional, de Oliveira, Edgar Borges, additional, El Khawanky, Nadia, additional, Ramos, Rodrigo Nalio, additional, Al-Ramadi, Basel K., additional, Segundo, Gesmar Rodrigues Silva, additional, Ochs, Hans D., additional, and Condino-Neto, Antonio, additional

Published
2019
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11. Azacytidine Sensitizes AML Cells for Effective Elimination By CD123 CAR T-Cells

Author

El Khawanky, Nadia, primary, Hughes, Amy, additional, Yu, Wenbo, additional, Taromi, Sanaz, additional, Clarson, Jade, additional, Lopez, Angel F., additional, Brown, Michael P., additional, Duyster, Justus, additional, Hughes, Timothy P., additional, White, Deborah L., additional, Yong, Agnes S. M., additional, and Zeiser, Robert, additional

Published
2019
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12. Demethylating therapy increases anti-CD123 CAR T cell cytotoxicity against acute myeloid leukemia

Author

Markus G. Manz, Deborah L. White, Jade Clarson, Konrad Aumann, Angel F. Lopez, Cornelius Miething, Wenbo Yu, Timothy P. Hughes, Lutz Hein, Janaki Manoja Vinnakota, Amy Hughes, Sanaz Taromi, Robert Zeiser, Tony Matschulla, Justus Duyster, Khalid Shoumariyeh, Agnes S. M. Yong, Renier Myburgh, Michael P. Brown, Nadia El Khawanky, University of Zurich, Yong, Agnes S M, Zeiser, Robert, El Khawanky, Nadia, Hughes, Amy, Yu, Wenbo, Myburgh, Renier, Matschulla, Tony, Taromi, Sanaz, Aumann, Konrad, Clarson, Jade, Vinnakota, Janaki Manoja, Shoumariyeh, Khalid, Miething, Cornelius, Lopez, Angel F, Brown, Michael P, Duyster, Justus, Hein, Lutz, Manz, Markus G, Hughes, Timothy P, White, Deborah L, and Yong, Agnes SM

Subjects
Cytotoxicity, Immunologic, medicine.medical_treatment, Cell, General Physics and Astronomy, Cancer immunotherapy, Kaplan-Meier Estimate, Immunotherapy, Adoptive, hemic and lymphatic diseases, demethylating therapy, Enzyme Inhibitors, cell cytotoxicity, Cytotoxicity, Cells, Cultured, Mice, Knockout, Receptors, Chimeric Antigen, Multidisciplinary, chimeric antigen receptor, Chemistry, Myeloid leukemia, 3100 General Physics and Astronomy, Leukemia, Haematopoiesis, medicine.anatomical_structure, Leukemia, Myeloid, Acute Disease, Azacitidine, Science, T cell, Immunology, Interleukin-3 Receptor alpha Subunit, Receptors, Antigen, T-Cell, HL-60 Cells, 610 Medicine & health, 1600 General Chemistry, acute myeloid leukemia, Article, Acute myeloid leukaemia, General Biochemistry, Genetics and Molecular Biology, 1300 General Biochemistry, Genetics and Molecular Biology, Cell Line, Tumor, medicine, Animals, Humans, neoplasms, General Chemistry, DNA Methylation, medicine.disease, Xenograft Model Antitumor Assays, Chimeric antigen receptor, HEK293 Cells, 10032 Clinic for Oncology and Hematology, Cancer research, human activities, Single-Chain Antibodies
Abstract

Successful treatment of acute myeloid leukemia (AML) with chimeric antigen receptor (CAR) T cells is hampered by toxicity on normal hematopoietic progenitor cells and low CAR T cell persistence. Here, we develop third-generation anti-CD123 CAR T cells with a humanized CSL362-based ScFv and a CD28-OX40-CD3ζ intracellular signaling domain. This CAR demonstrates anti-AML activity without affecting the healthy hematopoietic system, or causing epithelial tissue damage in a xenograft model. CD123 expression on leukemia cells increases upon 5′-Azacitidine (AZA) treatment. AZA treatment of leukemia-bearing mice causes an increase in CTLA-4negative anti-CD123 CAR T cell numbers following infusion. Functionally, the CTLA-4negative anti-CD123 CAR T cells exhibit superior cytotoxicity against AML cells, accompanied by higher TNFα production and enhanced downstream phosphorylation of key T cell activation molecules. Our findings indicate that AZA increases the immunogenicity of AML cells, enhancing recognition and elimination of malignant cells by highly efficient CTLA-4negative anti-CD123 CAR T cells., The success of CAR-T cells for treating acute myeloid leukaemia (AML) is hampered by toxicity to normal cells and low CAR-T cell persistence. Here, the authors show that the demethylating compound 5′-Azacitdine increases anti-CD123 CAR-T cell cytotoxicity against AML.

Published
2021
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