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8. Thymidine Kinase 1 Loss Confers Trifluridine Resistance without Affecting 5-Fluorouracil Metabolism and Cytotoxicity

Author

Edahiro, Keitaro, primary, Iimori, Makoto, additional, Kobunai, Takashi, additional, Morikawa-Ichinose, Tomomi, additional, Miura, Daisuke, additional, Kataoka, Yuki, additional, Niimi, Shinichiro, additional, Wakasa, Takeshi, additional, Saeki, Hiroshi, additional, Oki, Eiji, additional, Kitao, Hiroyuki, additional, and Maehara, Yoshihiko, additional

Published
2018
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9. Chemoradiotherapy for Solitary Skeletal Muscle Metastasis from Oesophageal Cancer: Case Report and Brief Literature Review.

Author

Fujimoto Y, Nakashima Y, Sasaki S, Jogo T, Hirose K, Edahiro K, Korehisa S, Taniguchi D, Kudou K, Nakaji YU, Nakanishi R, Ando K, Saeki H, Oki E, Fujiwara M, Oda Y, and Maehara Y

Subjects
Aged, Biomarkers, Tumor analysis, Biopsy, Carcinoma, Squamous Cell, Cisplatin administration & dosage, Esophageal Squamous Cell Carcinoma, Fluorouracil administration & dosage, Forearm, Humans, Immunohistochemistry, Magnetic Resonance Imaging, Male, Muscle Neoplasms chemistry, Muscle, Skeletal chemistry, Neoplasm Staging, Neoplasms, Squamous Cell chemistry, Positron-Emission Tomography, Time Factors, Treatment Outcome, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Chemoradiotherapy, Esophageal Neoplasms pathology, Muscle Neoplasms secondary, Muscle Neoplasms therapy, Muscle, Skeletal pathology, Neoplasms, Squamous Cell secondary, Neoplasms, Squamous Cell therapy
Abstract

Background: The incidence of skeletal muscle metastasis from oesophageal cancer is very low, and the treatment strategy has not been established., Case Report: A 77-year-old man underwent oesophagectomy following neoadjuvant chemotherapy for oesophageal squamous cell carcinoma (CT-pT3 N0 M0, CT-pStage II). Fourteen months after surgery, he became aware of a subcutaneous tumour in his left forearm. Computed tomography and fluorodeoxyglucose positron-emission tomography revealed a 65×75 mm intramuscular nodular lesion with a standardized uptake value of 8.5. Further examination by biopsy strongly suggested this was a solitary metastasis from oesophageal cancer. The patient received chemoradiotherapy with two cycles of 5-fluorouracil combined with cisplatin and radiation. Clinical complete response was confirmed by imaging 7 months after chemoradiation and no recurrence has occurred at 20 months since chemoradiation., Conclusion: Radiotherapy or chemoradiotherapy can be an alternative locoregional therapy to surgery for solitary skeletal muscle metastasis., (Copyright© 2017, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.)

Published
2017
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