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1. Enhanced fitness of SARS-CoV-2 variant of concern Alpha but not Beta

Author

Ulrich, Lorenz, Halwe, Nico Joel, Taddeo, Adriano, Ebert, Nadine, Schön, Jacob, Devisme, Christelle, Trüeb, Bettina Salome, Hoffmann, Bernd, Wider, Manon, Fan, Xiaoyu, Bekliz, Meriem, Essaidi-Laziosi, Manel, Schmidt, Marie Luisa, Niemeyer, Daniela, Corman, Victor Max, Kraft, Anna, Godel, Aurélie, Laloli, Laura, Kelly, Jenna N., Calderon, Brenda M., Breithaupt, Angele, Wylezich, Claudia, Berenguer Veiga, Inês, Gultom, Mitra, Osman, Sarah, Zhou, Bin, Adea, Kenneth, Meyer, Benjamin, Eberhardt, Christiane S., Thomann, Lisa, Gsell, Monika, Labroussaa, Fabien, Jores, Jörg, Summerfield, Artur, Drosten, Christian, Eckerle, Isabella Anne, Wentworth, David E., Dijkman, Ronald, Hoffmann, Donata, Thiel, Volker, Beer, Martin, and Benarafa, Charaf

Published
2022
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2. Neutralization capacity of antibodies elicited through homologous or heterologous infection or vaccination against SARS-CoV-2 VOCs

Author

Bekliz, Meriem, Adea, Kenneth, Vetter, Pauline, Eberhardt, Christiane S., Hosszu-Fellous, Krisztina, Vu, Diem-Lan, Puhach, Olha, Essaidi-Laziosi, Manel, Waldvogel-Abramowski, Sophie, Stephan, Caroline, L’Huillier, Arnaud G., Siegrist, Claire-Anne, Didierlaurent, Arnaud M., Kaiser, Laurent, Meyer, Benjamin, and Eckerle, Isabella

Published
2022
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3. A comparison of Sars-Cov-2 vaccine platforms: the CoviCompare project

Author

Molino, Diana, Durier, Christine, Radenne, Anne, Desaint, Corinne, Ropers, Jacques, Courcier, Soizic, Vieillard, Louis Victorien, Rekacewicz, Claire, Parfait, Beatrice, Appay, Victor, Batteux, Frédéric, Barillot, Emmanuel, Cogné, Michel, Combadière, Béhazine, Eberhardt, Christiane S., Gorochov, Guy, Hupé, Philippe, Ninove, Laetitia, Paul, Stéphane, Pellegrin, Isabelle, van der Werf, Sylvie, Lefebvre, Maeva, Botelho-Nevers, Elisabeth, Ortega-Perez, Inmaculada, Jaspard, Marie, Sow, Samba, Lelièvre, Jean Daniel, de Lamballerie, Xavier, Kieny, Marie Paule, Tartour, Eric, and Launay, Odile

Published
2022
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4. Robust innate responses to SARS-CoV-2 in children resolve faster than in adults without compromising adaptive immunity

Author

Vono, Maria, Huttner, Angela, Lemeille, Sylvain, Martinez-Murillo, Paola, Meyer, Benjamin, Baggio, Stephanie, Sharma, Shilpee, Thiriard, Anais, Marchant, Arnaud, Godeke, Gert-Jan, Reusken, Chantal, Alvarez, Catia, Perez-Rodriguez, Francisco, Eckerle, Isabella, Kaiser, Laurent, Loevy, Natasha, Eberhardt, Christiane S., Blanchard-Rohner, Geraldine, Siegrist, Claire-Anne, and Didierlaurent, Arnaud M.

Published
2021
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7. Antibody persistence in the first 6 months following SARS-CoV-2 infection among hospital workers: a prospective longitudinal study

Author

L'Huillier, Arnaud G., Meyer, Benjamin, Andrey, Diego O., Arm-Vernez, Isabelle, Baggio, Stephanie, Didierlaurent, Arnaud, Eberhardt, Christiane S., Eckerle, Isabella, Grasset-Salomon, Carole, Huttner, Angela, Posfay-Barbe, Klara M., Royo, Irene Sabater, Pralong, Jacques A., Vuilleumier, Nicolas, Yerly, Sabine, Siegrist, Claire-Anne, and Kaiser, Laurent

Published
2021
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8. Antibody response in children with multisystem inflammatory syndrome related to COVID-19 (MIS-C) compared to children with uncomplicated COVID-19

Author

Thiriard, Anaïs, primary, Meyer, Benjamin, additional, Eberhardt, Christiane S., additional, Loevy, Natasha, additional, Grazioli, Serge, additional, Adouan, Wafae, additional, Fontannaz, Paola, additional, Marechal, Fabienne, additional, L’Huillier, Arnaud G., additional, Siegrist, Claire-Anne, additional, Georges, Daphnée, additional, Putignano, Antonella, additional, Marchant, Arnaud, additional, Didierlaurent, Arnaud M., additional, and Blanchard-Rohner, Geraldine, additional

Published
2023
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9. T Cell Receptor Repertoire Profiling Reveals Breadth of Cellular Responses Against Sars-Cov-2 after Natural Infection and Vaccination in Allogeneic Hematopoietic Stem Cell Transplant Recipients

Author

Mamez, Anne-Claire, primary, Pradier, Amandine, additional, Stephan, Caroline, additional, Giannotti, Federica, additional, Masouridi-Levrat, Stavroula, additional, Morin, Sarah, additional, Neofytos, Dionysios, additional, Vu, Diem-Lan, additional, Melotti, Astrid, additional, Arm-Vernez, Isabelle, additional, Eberhardt, Christiane S., additional, Tamburini, Jerome, additional, Kaiser, Laurent, additional, Chalandon, Yves, additional, and Simonetta, Federico, additional

Published
2022
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10. Fitness of B-Cell Responses to SARS-CoV-2 WT and Variants Up to One Year After Mild COVID-19 – A Comprehensive Analysis

Author

Meyer, Benjamin, Martinez-Murillo, Paola Andrea, Lemaitre, Barbara, Blanchard-Rohner, Géraldine, Didierlaurent, Arnaud M., Fontannaz, Paola, Eugercios Manzanas, Chloé, Lambert, Paul-Henri, Loevy, Natasha, Kaiser, Laurent, Sartoretti, Julie, Tougne, Chantal, Villard, Jean, Huttner, Angela, Siegrist, Claire-Anne, and Eberhardt, Christiane S.

Subjects
Immunology, Immunology and Allergy
Published
2022
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11. Contrasting behavior between the three human monocyte subsets in dengue pathophysiology

Author

Maheshwari, Deepti, primary, Saini, Keshav, additional, Singh, Prabhat, additional, Singla, Mohit, additional, Nayak, Kaustuv, additional, Aggarwal, Charu, additional, Chawla, Yadya M., additional, Bajpai, Prashant, additional, Kaur, Manpreet, additional, Gunisetty, Sivaram, additional, Eberhardt, Christiane S., additional, Nyodu, Rajni, additional, Moore, Kathryn, additional, Suthar, Mehul S., additional, Medigeshi, Guruprasad R., additional, Anderson, Evan, additional, Lodha, Rakesh, additional, Kabra, Sushil K., additional, Ahmed, Rafi, additional, Chandele, Anmol, additional, and Murali-Krishna, Kaja, additional

Published
2022
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12. Enhanced fitness of SARS-CoV-2 variant of concern Alpha but not Beta

Author

Ulrich, Lorenz, primary, Halwe, Nico Joel, additional, Taddeo, Adriano, additional, Ebert, Nadine, additional, Schön, Jacob, additional, Devisme, Christelle, additional, Trüeb, Bettina Salome, additional, Hoffmann, Bernd, additional, Wider, Manon, additional, Fan, Xiaoyu, additional, Bekliz, Meriem, additional, Essaidi-Laziosi, Manel, additional, Schmidt, Marie Luisa, additional, Niemeyer, Daniela, additional, Corman, Victor Max, additional, Kraft, Anna, additional, Godel, Aurélie, additional, Laloli, Laura, additional, Kelly, Jenna N., additional, Calderon, Brenda M., additional, Breithaupt, Angele, additional, Wylezich, Claudia, additional, Berenguer Veiga, Inês, additional, Gultom, Mitra, additional, Osman, Sarah, additional, Zhou, Bin, additional, Adea, Kenneth, additional, Meyer, Benjamin, additional, Eberhardt, Christiane S., additional, Thomann, Lisa, additional, Gsell, Monika, additional, Labroussaa, Fabien, additional, Jores, Jörg, additional, Summerfield, Artur, additional, Drosten, Christian, additional, Eckerle, Isabella Anne, additional, Wentworth, David E., additional, Dijkman, Ronald, additional, Hoffmann, Donata, additional, Thiel, Volker, additional, Beer, Martin, additional, and Benarafa, Charaf, additional

Published
2021
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15. Clinical, virologic and immunologic features of a mild case of SARS-CoV-2 reinfection

Author

Vetter, Pauline, primary, Cordey, Samuel, additional, Schibler, Manuel, additional, Vieux, Laure, additional, Despres, Lena, additional, Laubscher, Florian, additional, Andrey, Diego O., additional, Martischang, Romain, additional, Harbarth, Stephan, additional, Cuvelier, Clémence, additional, Bekliz, Meriem, additional, Eckerle, Isabella, additional, Siegrist, Claire-Anne, additional, Didierlaurent, Arnaud M., additional, Eberhardt, Christiane S., additional, Meyer, Benjamin, additional, and Kaiser, Laurent, additional

Published
2021
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17. Daily Viral Kinetics and Innate and Adaptive Immune Response Assessment in COVID-19: a Case Series

Author

Vetter, Pauline, primary, Eberhardt, Christiane S., additional, Meyer, Benjamin, additional, Martinez Murillo, Paola Andrea, additional, Torriani, Giulia, additional, Pigny, Fiona, additional, Lemeille, Sylvain, additional, Cordey, Samuel, additional, Laubscher, Florian, additional, Vu, Diem-Lan, additional, Calame, Adrien, additional, Schibler, Manuel, additional, Jacquerioz, Frederique, additional, Blanchard-Rohner, Géraldine, additional, Siegrist, Claire-Anne, additional, Kaiser, Laurent, additional, Didierlaurent, Arnaud M., additional, and Eckerle, Isabella, additional

Published
2020
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18. Defining HPV-specific B cell responses in patients with head and neck cancer

Author

Wieland, Andreas, primary, Patel, Mihir R., additional, Cardenas, Maria A., additional, Eberhardt, Christiane S., additional, Hudson, William H., additional, Obeng, Rebecca C., additional, Griffith, Christopher C., additional, Wang, Xu, additional, Chen, Zhuo G., additional, Kissick, Haydn T., additional, Saba, Nabil F., additional, and Ahmed, Rafi, additional

Published
2020
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21. Persistence of Varicella-Zoster Virus-Specific Plasma Cells in Adult Human Bone Marrow following Childhood Vaccination

Author

Eberhardt, Christiane S., primary, Wieland, Andreas, additional, Nasti, Tahseen H., additional, Grifoni, Alba, additional, Wilson, Elizabeth, additional, Schmid, D. Scott, additional, Pulendran, Bali, additional, Sette, Alessandro, additional, Waller, Edmund K., additional, Rouphael, Nadine, additional, and Ahmed, Rafi, additional

Published
2020
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22. Functional HPV-specific PD-1+ stem-like CD8 T cells in head and neck cancer.

Author

Eberhardt, Christiane S., Kissick, Haydn T., Patel, Mihir R., Cardenas, Maria A., Prokhnevska, Nataliya, Obeng, Rebecca C., Nasti, Tahseen H., Griffith, Christopher C., Im, Se Jin, Wang, Xu, Shin, Dong M., Carrington, Mary, Chen, Zhuo G., Sidney, John, Sette, Alessandro, Saba, Nabil F., Wieland, Andreas, and Ahmed, Rafi

Abstract

T cells are important in tumour immunity but a better understanding is needed of the differentiation of antigen-specific T cells in human cancer1,2. Here we studied CD8 T cells in patients with human papillomavirus (HPV)-positive head and neck cancer and identified several epitopes derived from HPV E2, E5 and E6 proteins that allowed us to analyse virus-specific CD8 T cells using major histocompatibility complex (MHC) class I tetramers. HPV-specific CD8 T cells expressed PD-1 and were detectable in the tumour at levels that ranged from 0.1% to 10% of tumour-infiltrating CD8 T lymphocytes (TILs) for a given epitope. Single-cell RNA-sequencing analyses of tetramer-sorted HPV-specific PD-1+ CD8 TILs revealed three transcriptionally distinct subsets. One subset expressed TCF7 and other genes associated with PD-1+ stem-like CD8 T cells that are critical for maintaining T cell responses in conditions of antigen persistence. The second subset expressed more effector molecules, representing a transitory cell population, and the third subset was characterized by a terminally differentiated gene signature. T cell receptor clonotypes were shared between the three subsets and pseudotime analysis suggested a hypothetical differentiation trajectory from stem-like to transitory to terminally differentiated cells. More notably, HPV-specific PD-1+TCF-1+ stem-like TILs proliferated and differentiated into more effector-like cells after in vitro stimulation with the cognate HPV peptide, whereas the more terminally differentiated cells did not proliferate. The presence of functional HPV-specific PD-1+TCF-1+CD45RO+ stem-like CD8 T cells with proliferative capacity shows that the cellular machinery to respond to PD-1 blockade exists in HPV-positive head and neck cancer, supporting the further investigation of PD-1 targeted therapies in this malignancy. Furthermore, HPV therapeutic vaccination efforts have focused on E6 and E7 proteins; our results suggest that E2 and E5 should also be considered for inclusion as vaccine antigens to elicit tumour-reactive CD8 T cell responses of maximal breadth.An analysis of human papillomavirus (HPV)-specific CD8 T cells in patients with head and neck cancer identifies functional PD-1+TCF-1+CD8 T cells in the tumour with implications for therapeutic vaccination and PD-1 directed immunotherapy. [ABSTRACT FROM AUTHOR]

Published
2021
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23. Y-box protein-1/p18 fragment identifies malignancies in patients with chronic liver disease

Author

Shpacovitch Victoria, Eberhardt Christiane S, Kaehne Thilo, En-Nia Abdelaziz, Kanig Nicolas, Tacke Frank, Trautwein Christian, and Mertens Peter R

Subjects
cold shock proteins, liver transplantation, hepatocellular carcinoma, cancer screening, serum markers, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background Immunohistochemical detection of cold shock proteins is predictive for deleterious outcome in various malignant diseases. We recently described active secretion of a family member, denoted Y-box (YB) protein-1. We tested the clinical and diagnostic value of YB-1 protein fragment p18 (YB-1/p18) detection in blood for malignant diseases. Methods We used a novel monoclonal anti-YB-1 antibody to detect YB-1/p18 by immunoblotting in plasma samples of healthy volunteers (n = 33), patients with non-cancerous, mostly inflammatory diseases (n = 60), hepatocellular carcinoma (HCC; n = 25) and advanced solid tumors (n = 20). YB-1/p18 was then tested in 111 patients with chronic liver diseases, alongside established tumor markers and various diagnostic measures, during evaluation for potential liver transplantation. Results We developed a novel immunoblot to detect the 18 kD fragment of secreted YB-1 in human plasma (YB-1/p18) that contains the cold-shock domains (CSD) 1-3 of the full-length protein. YB-1/p18 was detected in 11/25 HCC and 16/20 advanced carcinomas compared to 0/33 healthy volunteers and 10/60 patients with non-cancerous diseases. In 111 patients with chronic liver disease, YB-1/p18 was detected in 20 samples. Its occurrence was not associated with advanced Child stages of liver cirrhosis or liver function. In this cohort, YB-1/p18 was not a good marker for HCC, but proved most powerful in detecting malignancies other than HCC (60% positive) with a lower rate of false-positive results compared to established tumor markers. Alpha-fetoprotein (AFP) was most sensitive in detecting HCC, but simultaneous assessment of AFP, CA19-9 and YB-1/p18 improved overall identification of HCC patients. Conclusions Plasma YB-1/p18 can identify patients with malignancies, independent of acute inflammation, renal impairment or liver dysfunction. The detection of YB-1/p18 in human plasma may have potential as a tumor marker for screening of high-risk populations, e.g. before organ transplantation, and should therefore be evaluated in larger prospective studies.

Published
2011
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24. Functional HPV-specific PD-1+stem-like CD8 T cells in head and neck cancer

Author

Eberhardt, Christiane S., Kissick, Haydn T., Patel, Mihir R., Cardenas, Maria A., Prokhnevska, Nataliya, Obeng, Rebecca C., Nasti, Tahseen H., Griffith, Christopher C., Im, Se Jin, Wang, Xu, Shin, Dong M., Carrington, Mary, Chen, Zhuo G., Sidney, John, Sette, Alessandro, Saba, Nabil F., Wieland, Andreas, and Ahmed, Rafi

Abstract

T cells are important in tumour immunity but a better understanding is needed of the differentiation of antigen-specific T cells in human cancer1,2. Here we studied CD8 T cells in patients with human papillomavirus (HPV)-positive head and neck cancer and identified several epitopes derived from HPV E2, E5 and E6 proteins that allowed us to analyse virus-specific CD8 T cells using major histocompatibility complex (MHC) class I tetramers. HPV-specific CD8 T cells expressed PD-1 and were detectable in the tumour at levels that ranged from 0.1% to 10% of tumour-infiltrating CD8 T lymphocytes (TILs) for a given epitope. Single-cell RNA-sequencing analyses of tetramer-sorted HPV-specific PD-1+CD8 TILs revealed three transcriptionally distinct subsets. One subset expressed TCF7and other genes associated with PD-1+stem-like CD8 T cells that are critical for maintaining T cell responses in conditions of antigen persistence. The second subset expressed more effector molecules, representing a transitory cell population, and the third subset was characterized by a terminally differentiated gene signature. T cell receptor clonotypes were shared between the three subsets and pseudotime analysis suggested a hypothetical differentiation trajectory from stem-like to transitory to terminally differentiated cells. More notably, HPV-specific PD-1+TCF-1+stem-like TILs proliferated and differentiated into more effector-like cells after in vitro stimulation with the cognate HPV peptide, whereas the more terminally differentiated cells did not proliferate. The presence of functional HPV-specific PD-1+TCF-1+CD45RO+stem-like CD8 T cells with proliferative capacity shows that the cellular machinery to respond to PD-1 blockade exists in HPV-positive head and neck cancer, supporting the further investigation of PD-1 targeted therapies in this malignancy. Furthermore, HPV therapeutic vaccination efforts have focused on E6 and E7 proteins; our results suggest that E2 and E5 should also be considered for inclusion as vaccine antigens to elicit tumour-reactive CD8 T cell responses of maximal breadth.

Published
2021
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26. No association of IL-12p40 pro1.1 polymorphism with juvenile idiopathic arthritis

Author

Eberhardt, Christiane S., primary, Haas, Johannes-Peter, additional, Girschick, Hermann, additional, Schwarz, Tobias, additional, Morbach, Henner, additional, Rösen-Wolff, Angela, additional, Foell, Dirk, additional, Dannecker, Guenther, additional, Schepp, Carsten, additional, Ganser, Gerd, additional, Honke, Nora, additional, Eggermann, Thomas, additional, Müller-Berghaus, Jan, additional, Wagner, Norbert, additional, Ohl, Kim, additional, and Tenbrock, Klaus, additional

Published
2015
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29. Influenza Immunization in the Context of Preexisting Immunity.

Author

Linderman SL, Ellebedy AH, Davis C, Eberhardt CS, Antia R, Ahmed R, and Zarnitsyna VI

Subjects
Antibodies, Viral immunology, Humans, Vaccination, Immunity, Humoral, Influenza, Human prevention & control
Abstract

Although we develop influenza immunity from an early age, it is insufficient to prevent future infection with antigenically novel strains. One proposed way to generate long-term protective immunity against a broad range of influenza virus strains is to boost responses to the conserved epitopes on the hemagglutinin, the major surface glycoprotein on the influenza virus. Influenza-specific humoral immunity comprises a large fraction of the overall immune memory in humans, and it has been long recognized that preexisting immunity to influenza shapes the response to subsequent influenza infections and vaccinations. However, the mechanisms by which preexisting immunity modulates the response to influenza vaccination are still not completely understood. Using a set of mathematical models, we explore several hypotheses that may contribute to diminished boosting of antibodies to conserved epitopes after repeated vaccinations., (Copyright © 2021 Cold Spring Harbor Laboratory Press; all rights reserved.)

Published
2021
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