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2. Co-sensitization to the three non-homologous major cashew allergens Ana o 1, Ana o 2 and Ana o 3 is caused by IgE cross-reactivity

Author

Kabasser, S, primary, Radauer, C, additional, Eber, E, additional, Haber, ME, additional, Hieden, K, additional, Zieglmayer, P, additional, Kost, LE, additional, Sindher, SB, additional, Chinthrajah, S, additional, Geiselhart, S, additional, Hoffmann-Sommergruber, K, additional, Nadeau, KC, additional, Breiteneder, H, additional, and Bublin, M, additional

Published
2022
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3. WS14.03 Cystic Fibrosis-Related Diabetes is not associated with maximal aerobic exercise capacity in cystic fibrosis (CF): a cross-sectional analysis of an international multicentre trial (ACTIVATE-CF)

Author

Radtke, T., primary, Kriemler, S., additional, Stein, L., additional, Karila, C., additional, Urquhart, D.S, additional, Orenstein, D.M, additional, Lands, L.C, additional, Schindler, C., additional, Eber, E., additional, Haile, S.R, additional, and Hebestreit, H., additional

Published
2022
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5. International BEAT-PCD consensus statement for infection prevention and control for primary ciliary dyskinesia in collaboration with ERN-LUNG PCD Core Network and patient representatives.

Author

Marthin, JK, Lucas, JS, Boon, M, Casaulta, C, Crowley, S, Destouches, DMS, Eber, E, Escribano, A, Haarman, E, Hogg, C, Maitre, B, Marsh, G, Martinu, V, Moreno-Galdó, A, Mussaffi, H, Omran, H, Pohunek, P, Rindlisbacher, B, Robinson, P, Snijders, D, Walker, WT, Yiallouros, P, Johansen, HK, Nielsen, KG, Marthin, JK, Lucas, JS, Boon, M, Casaulta, C, Crowley, S, Destouches, DMS, Eber, E, Escribano, A, Haarman, E, Hogg, C, Maitre, B, Marsh, G, Martinu, V, Moreno-Galdó, A, Mussaffi, H, Omran, H, Pohunek, P, Rindlisbacher, B, Robinson, P, Snijders, D, Walker, WT, Yiallouros, P, Johansen, HK, and Nielsen, KG

Abstract

INTRODUCTION: In primary ciliary dyskinesia (PCD) impaired mucociliary clearance leads to recurrent airway infections and progressive lung destruction, and concern over chronic airway infection and patient-to-patient transmission is considerable. So far, there has been no defined consensus on how to control infection across centres caring for patients with PCD. Within the BEAT-PCD network, COST Action and ERS CRC together with the ERN-Lung PCD core a first initiative has now been taken towards creating such a consensus statement. METHODS: A multidisciplinary international PCD expert panel was set up to create a consensus statement for infection prevention and control (IP&C) for PCD, covering diagnostic microbiology, infection prevention for specific pathogens considered indicated for treatment and segregation aspects. Using a modified Delphi process, consensus to a statement demanded at least 80% agreement within the PCD expert panel group. Patient organisation representatives were involved throughout the process. RESULTS: We present a consensus statement on 20 IP&C statements for PCD including suggested actions for microbiological identification, indications for treatment of Pseudomonas aeruginosa, Burkholderia cepacia and nontuberculous mycobacteria and suggested segregation aspects aimed to minimise patient-to-patient transmission of infections whether in-hospital, in PCD clinics or wards, or out of hospital at meetings between people with PCD. The statement also includes segregation aspects adapted to the current coronavirus disease 2019 (COVID-19) pandemic. CONCLUSION: The first ever international consensus statement on IP&C intended specifically for PCD is presented and is targeted at clinicians managing paediatric and adult patients with PCD, microbiologists, patient organisations and not least the patients and their families.

Published
2021

6. Stellungnahme der Österreichischen Gesellschaft für Pneumologie (ÖGP)

Author

Flick, H., Arns, B. M., Bolitschek, J., Bucher, B., Cima, K., Gingrich, E., Handzhiev, S., Hochmair, M., Horak, F., Idzko, M., Jaksch, P., Kovacs, G., Kropfmüller, R., Lamprecht, B., Löffler-Ragg, J., Meilinger, M., Olschewski, H., Pfleger, A., Puchner, B., Puelacher, C., Prior, C., Rodriguez, P., Salzer, H., Schenk, P., Schindler, O., Stelzmüller, I., Strenger, V., Täubl, H., Urban, M., Wagner, M., Wimberger, F., Zacharasiewicz, A., Zwick, R. H., and Eber, E.

Published
2020
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8. Partial splenectomy in cystic fibrosis patients with hypersplenism. (Case Report)

Author

Thalhammer, G.H., Eber, E., Uranus, S., Pfeifer, J., and Zach, M.S.

Subjects
Cystic fibrosis -- Care and treatment -- Complications and side effects, Splenectomy, Family and marriage, Health, Care and treatment, Complications and side effects
Abstract

We report three cystic fibrosis (CF) patients with hypersplenism who underwent partial splenectomy. The postoperative course was uneventful in two patients; one patient developed a complication necessitating resection of the [...]

Published
2003

9. Adult outcome of congenital lower respiratory tract malformations. (Paediatric Origins of Adult Lung Diseases)

Author

Zach, M.S. and Eber, E.

Subjects
Birth defects -- Care and treatment -- Research, Respiratory physiology -- Methods -- Research, Respiratory organs -- Assessment, Family and marriage, Health, Care and treatment, Research, Methods
Abstract

Congenital malformations of the lower respiratory tract are usually diagnosed and managed in the newborn period, in infancy, or in childhood. To what extent should the adult pulmonologist be experienced [...]

Published
2002

11. ERS statement on standardisation of cardiopulmonary exercise testing in chronic lung diseases

Author

Radtke, T. Crook, S. Kaltsakas, G. Louvaris, Z. Berton, D. Urquhart, D.S. Kampouras, A. Rabinovich, R.A. Verges, S. Kontopidis, D. Boyd, J. Tonia, T. Langer, D. De Brandt, J. Goërtz, Y.M.J. Burtin, C. Spruit, M.A. Braeken, D.C.W. Dacha, S. Franssen, F.M.E. Laveneziana, P. Eber, E. Troosters, T. Neder, J.A. Puhan, M.A. Casaburi, R. Vogiatzis, I. Hebestreit, H.

Abstract

The objective of this document was to standardise published cardiopulmonary exercise testing (CPET) protocols for improved interpretation in clinical settings and multicentre research projects. This document: 1) summarises the protocols and procedures used in published studies focusing on incremental CPET in chronic lung conditions; 2) presents standard incremental protocols for CPET on a stationary cycle ergometer and a treadmill; and 3) provides patients’ perspectives on CPET obtained through an online survey supported by the European Lung Foundation. We systematically reviewed published studies obtained from EMBASE, Medline, Scopus, Web of Science and the Cochrane Library from inception to January 2017. Of 7914 identified studies, 595 studies with 26 523 subjects were included. The literature supports a test protocol with a resting phase lasting at least 3 min, a 3-min unloaded phase, and an 8-to 12-min incremental phase with work rate increased linearly at least every minute, followed by a recovery phase of at least 2–3 min. Patients responding to the survey (n=295) perceived CPET as highly beneficial for their diagnostic assessment and informed the Task Force consensus. Future research should focus on the individualised estimation of optimal work rate increments across different lung diseases, and the collection of robust normative data. © ERS 2019.

Published
2019

12. ERS statement on tracheomalacia and bronchomalacia in children

Author

Wallis, C. Alexopoulou, E. Antón-Pacheco, J.L. Bhatt, J.M. Bush, A. Chang, A.B. Charatsi, A.-M. Coleman, C. Depiazzi, J. Douros, K. Eber, E. Everard, M. Kantar, A. Masters, I.B. Midulla, F. Nenna, R. Roebuck, D. Snijders, D. Priftis, K.

Abstract

Tracheomalacia and tracheobronchomalacia may be primary abnormalities of the large airways or associated with a wide variety of congenital and acquired conditions. The evidence on diagnosis, classification and management is scant. There is no universally accepted classification of severity. Clinical presentation includes early-onset stridor or fixed wheeze, recurrent infections, brassy cough and even near-death attacks, depending on the site and severity of the lesion. Diagnosis is usually made by flexible bronchoscopy in a free-breathing child but may also be shown by other dynamic imaging techniques such as low-contrast volume bronchography, computed tomography or magnetic resonance imaging. Lung function testing can provide supportive evidence but is not diagnostic. Management may be medical or surgical, depending on the nature and severity of the lesions, but the evidence base for any therapy is limited. While medical options that include bronchodilators, anti-muscarinic agents, mucolytics and antibiotics (as well as treatment of comorbidities and associated conditions) are used, there is currently little evidence for benefit. Chest physiotherapy is commonly prescribed, but the evidence base is poor. When symptoms are severe, surgical options include aortopexy or posterior tracheopexy, tracheal resection of short affected segments, internal stents and external airway splinting. If respiratory support is needed, continuous positive airway pressure is the most commonly used modality either via a face mask or tracheostomy. Parents of children with tracheobronchomalacia report diagnostic delays and anxieties about how to manage their child's condition, and want more information. There is a need for more research to establish an evidence base for malacia. This European Respiratory Society statement provides a review of the current literature to inform future study. Copyright © ERS 2019

Published
2019

13. Plasma lipid profiles discriminate bacterial from viral infection in febrile children

Author

Wang, X. (Xinzhu), Nijman, R.G. (Ruud), Camuzeaux, S. (Stephane), Sands, C. (Caroline), Jackson, H. (Heather), Kaforou, M. (Myrsini), Emonts, M. (Marieke), Herberg, J.A. (Jethro A.), MacOnochie, I.K. (Ian), Carrol, E.D. (Enitan), Paulus, S.C. (Stephane C.), Zenz, W. (Werner), Flier, M. (Michiel) van der, Groot, R. (Ronald) de, Martinon-Torres, F. (Federico), Schlapbach, L.J. (Luregn), Pollard, A.J. (Andrew J.), Fink, C. (Colin), Kuijpers, T.T. (Taco T.), Anderson, S. (Suzanne), Lewis, M.R. (Matthew R.), Levin, M. (Michael), McClure, M. (Myra), Gormley, S. (Stuart), Hamilton, S. (Shea), Hourmat, B. (Bernardo), Hoggart, C. (Clive), Sancho-Shimizu, V. (Vanessa), Wright, V.J. (Victoria), Abdulla, A. (Amina), Agapow, P. (Paul), Bartlett, M. (Maeve), Bellos, E. (Evangelos), Eleftherohorinou, H. (Hariklia), Galassini, R. (Rachel), Inwald, D. (David), Mashbat, M. (Meg), Menikou, S. (Stefanie), Mustafa, S. (Sobia), Nadel, S. (Simon), Rahman, R. (Rahmeen), Thakker, C. (Clare), Coin, L.M.J. (Lachlan M. J.), Bokhandi, S. (S.), Power, S. (Sue), Barham, H. (Heather), Pathan, D.N. (Dr N), Ridout, J. (Jenna), White, D. (Deborah), Thurston, S. (Sarah), Faust, D. (Dominik), Patel, S.Y. (Smita Y.), McCorkell, J. (Jenni), Davies, P. (P.), Crate, L. (Lindsey), Navarra, H. (Helen), Carter, S. (Stephanie), Ramaiah, R. (R.), Patel, R. (Rekha), Tuffrey, C. (Catherine), Gribbin, A. (Andrew), McCready, S. (Sharon), Peters, M. (Mark), Hardy, K. (Katie), Standing, F. (Fran), O’Neill, L. (Lauren), Abelake, E. (Eugenia), Deep, A. (Akash), Nsirim, E. (Eniola), Willis, L. (Louise), Young, Z. (Zoe), Royad, C. (C.), White, S. (Sonia), Fortune, P.M. (P. M.), Hudnott, P. (Phil), González, F.Á. (Fernando Álvez), Barral-Arca, R. (Ruth), Cebey-López, M. (Miriam), Curras-Tuala, M.J. (María José), García, N. (Natalia), Vicente, L.G. (Luisa García), Gómez-Carballa, A. (Alberto), Rial, J.G. (Jose Gómez), Beiroa, A.G. (Andrea Grela), Grande, A.J. (Antonio Justicia), Iglesias, P.L. (Pilar Leboráns), Santos, A.E.M. (Alba Elena Martínez), Martinón-Torres, F. (Federico), MartinónTorres, N. (Nazareth), Sánchez, J.M.M. (José María Martinón), Gutiérrez, B.M. (Beatriz Morillo), Pérez, B.M. (Belén Mosquera), Pacheco, P.O. (Pablo Obando), Pardo-Seco, J. (Jacobo), Pischedda, S. (Sara), RiveroCalle, I. (Irene), Rodríguez-Tenreiro, C. (Carmen), Redondo-Collazo, L. (Lorenzo), Ellacuriagal, A.S. (Antonio Salas), Fernández, S.S. (Sonia Serén), Silva, M.S.P. (María del Sol Porto), Vega, A. (Ana), Trillo, L.V. (Lucía Vilanova), Salas, A. (Antonio), Reyes, S.B. (Susana Beatriz), León, M.C.L. (María Cruz León), Mingorance, Á.N. (Álvaro Navarro), Barrios, X.G. (Xavier Gabaldó), Vergara, E.O. (Eider Oñate), Torre, A.C. (Andrés Concha), Vivanco, A. (Ana), Fernández, R. (Reyes), Sánchez, F.G. (Francisco Giménez), Forte, M.S. (Miguel Sánchez), Rojo, P. (Pablo), Contreras, J.R. (J. Ruiz), Palacios, A. (Alba), Ibarrondo, C.E. (Cristina Epalza), Cooke, E.F. (Elizabeth Fernández), Navarro, M. (Marisa), Álvarez, C.Á. (Cristina Álvarez), Lozano, M.J. (María José), Carreras, E. (Eduardo), Sanagustín, S.B. (Sonia Brió), Neth, O. (Olaf), Padilla, M.C.M. (Ma del Carmen Martínez), Tato, L.M.P. (Luis Manuel Prieto), Guillén, S. (Sara), Silveira, L.F. (Laura Fernández), Moreno, D. (David), van Furth, A.M.T. (A. M. Tutu), Boeddha, N.P. (Navin), Driessen, G.J.A. (Gertjan), Hazelzet, J.A. (Jan), Pajkrt, D. (D.), Sanders, E.A.M. (E. A.M.), van de Beek, D. (D.), Ende, A. (A.) van der, Philipsen, H.L.A. (H. L.A.), Adeel, A.O.A. (A. O.A.), Breukels, M.A. (M. A.), Brinkman, D.M.C., de Korte, C.C.M.M. (C. C.M.M.), de Vries, E. (E.), Waal, W.J. (Wouter) de, Dekkers, R. (R.), Dings-Lammertink, A. (A.), Doedens, R.A. (R. A.), Donker, A.E. (A.), Dousma, M. (M.), Faber, T.E. (T. E.), Gerrit, G.P.J.M. (Gerardus), Gerver, J.A.M. (J. A.M.), Heidema, J. (Jojanneke), Veen, J.H.-V. (J. Homan-van der), Jacobs, M.A.M. (M. A.M.), Jansen, N.J.G. (N. J.G.), Kawczynski, P. (P.), Klucovska, K. (K.), Kneyber, M.C.J. (M. C.J.), Koopman-Keemink, Y. (Yvonne), Langenhorst, V.J. (V. J.), Leusink, J. (J.), Loza, B.F. (Bettina F.), Merth, I.T. (I. T.), Miedema, C.J. (C. J.), Neeleman, C. (C.), Noordzij, J.G. (Jeroen), Obihara, C.C. (Charlie C.), van Overbeek – van Gils, A.L.T. (A. L.T.), Poortman, G.H. (G. H.), Potgieter, S.T. (S. T.), Potjewijd, J. (J.), Rosias, P.P.R. (Philippe), Sprong, T. (Tom), ten Tussher, G.W. (G. W.), Thio, B.J. (B. J.), Tramper-Stranders, G.A. (Gerdien), Deuren, M. (Marcel) van, van der Meer, H. (H.), van Kuppevelt, A.J.M. (A. J.M.), van Wermeskerken, A.M. (A. M.), Verwijs, W.A. (W. A.), Wolfs, T.F.W. (T. F.W.), Agyeman, P. (Philipp), Aebi, C. (Christoph), Berger, C. (Christoph), Giannoni, P., Stocker, M. (Martin), Posfay-Barbe, K.M. (Klara M.), Heininger, U. (Ulrich), Bernhard-Stirnemann, S. (Sara), Niederer-Loher, A. (Anita), Kahlert, C. (Christian), Hasters, P. (Paul), Relly, C. (Christa), Baer, W. (Walter), Frederick, H. (Hannah), Jennings, R. (Rebecca), Johnston, J. (Joanne), Kenwright, R. (Rhian), Pinnock, E. (Elli), Agbeko, R. (Rachel), Secka, F. (Fatou), Bojang, K. (Kalifa), Sarr, I. (Isatou), Kebbeh, N. (Ngange), Sey, G. (Gibbi), Momodou, (), khan, S. (Saidy), Cole, F. (Fatoumata), Thomas, G. (Gilleh), Antonio, M. (Martin), Klobassa, D.S. (Daniela S.), Binder, A. (Alexander), Schweintzger, N.A. (Nina A.), Sagmeister, M. (Manfred), Baumgart, H. (Hinrich), Baumgartner, M. (Markus), Behrends, U. (Uta), Biebl, A. (Ariane), Birnbacher, R. (Robert), Blanke, J.-G. (Jan-Gerd), Boelke, C. (Carsten), Breuling, K. (Kai), Brunner, J. (Jürgen), Buller, M. (Maria), Dahlem, P. (Peter), Dietrich, B. (Beate), Eber, E. (Ernst), Elias, J. (Johannes), Emhofer, J. (Josef), Etschmaier, R. (Rosa), Farr, S. (Sebastian), Girtler, Y. (Ylenia), Grigorow, I. (Irina), Heimann, K. (Konrad), Ihm, U. (Ulrike), Jaros, Z. (Zdenek), Kalhoff, H. (Hermann), Kaulfersch, W. (Wilhelm), Kemen, C. (Christoph), Klocker, N. (Nina), Köster, B. (Bernhard), Kohlmaier, B. (Benno), Komini, E. (Eleni), Kramer, L. (Lydia), Neubert, A. (Antje), Ortner, D. (Daniel), Pescollderungg, L. (Lydia), Pfurtscheller, K. (Klaus), Reiter, K. (Karl), Ristic, G. (Goran), Rödl, S. (Siegfried), Sellner, A. (Andrea), Sonnleitner, A. (Astrid), Sperl, M. (Matthias), Stelzl, W. (Wolfgang), Till, H. (Holger), Trobisch, A. (Andreas), Vierzig, A. (Anne), Vogel, U. (Ulrich), Weingarten, C. (Christina), Welke, S. (Stefanie), Wimmer, A. (Andreas), Wintergerst, U. (Uwe), Wüller, D. (Daniel), Zaunschirm, A. (Andrew), Ziuraite, I. (Ieva), Žukovskaja, V. (Veslava), Wang, X. (Xinzhu), Nijman, R.G. (Ruud), Camuzeaux, S. (Stephane), Sands, C. (Caroline), Jackson, H. (Heather), Kaforou, M. (Myrsini), Emonts, M. (Marieke), Herberg, J.A. (Jethro A.), MacOnochie, I.K. (Ian), Carrol, E.D. (Enitan), Paulus, S.C. (Stephane C.), Zenz, W. (Werner), Flier, M. (Michiel) van der, Groot, R. (Ronald) de, Martinon-Torres, F. (Federico), Schlapbach, L.J. (Luregn), Pollard, A.J. (Andrew J.), Fink, C. (Colin), Kuijpers, T.T. (Taco T.), Anderson, S. (Suzanne), Lewis, M.R. (Matthew R.), Levin, M. (Michael), McClure, M. (Myra), Gormley, S. (Stuart), Hamilton, S. (Shea), Hourmat, B. (Bernardo), Hoggart, C. (Clive), Sancho-Shimizu, V. (Vanessa), Wright, V.J. (Victoria), Abdulla, A. (Amina), Agapow, P. (Paul), Bartlett, M. (Maeve), Bellos, E. (Evangelos), Eleftherohorinou, H. (Hariklia), Galassini, R. (Rachel), Inwald, D. (David), Mashbat, M. (Meg), Menikou, S. (Stefanie), Mustafa, S. (Sobia), Nadel, S. (Simon), Rahman, R. (Rahmeen), Thakker, C. (Clare), Coin, L.M.J. (Lachlan M. J.), Bokhandi, S. (S.), Power, S. (Sue), Barham, H. (Heather), Pathan, D.N. (Dr N), Ridout, J. (Jenna), White, D. (Deborah), Thurston, S. (Sarah), Faust, D. (Dominik), Patel, S.Y. (Smita Y.), McCorkell, J. (Jenni), Davies, P. (P.), Crate, L. (Lindsey), Navarra, H. (Helen), Carter, S. (Stephanie), Ramaiah, R. (R.), Patel, R. (Rekha), Tuffrey, C. (Catherine), Gribbin, A. (Andrew), McCready, S. (Sharon), Peters, M. (Mark), Hardy, K. (Katie), Standing, F. (Fran), O’Neill, L. (Lauren), Abelake, E. (Eugenia), Deep, A. (Akash), Nsirim, E. (Eniola), Willis, L. (Louise), Young, Z. (Zoe), Royad, C. (C.), White, S. (Sonia), Fortune, P.M. (P. M.), Hudnott, P. (Phil), González, F.Á. (Fernando Álvez), Barral-Arca, R. (Ruth), Cebey-López, M. (Miriam), Curras-Tuala, M.J. (María José), García, N. (Natalia), Vicente, L.G. (Luisa García), Gómez-Carballa, A. (Alberto), Rial, J.G. (Jose Gómez), Beiroa, A.G. (Andrea Grela), Grande, A.J. (Antonio Justicia), Iglesias, P.L. (Pilar Leboráns), Santos, A.E.M. (Alba Elena Martínez), Martinón-Torres, F. (Federico), MartinónTorres, N. (Nazareth), Sánchez, J.M.M. (José María Martinón), Gutiérrez, B.M. (Beatriz Morillo), Pérez, B.M. (Belén Mosquera), Pacheco, P.O. (Pablo Obando), Pardo-Seco, J. (Jacobo), Pischedda, S. (Sara), RiveroCalle, I. (Irene), Rodríguez-Tenreiro, C. (Carmen), Redondo-Collazo, L. (Lorenzo), Ellacuriagal, A.S. (Antonio Salas), Fernández, S.S. (Sonia Serén), Silva, M.S.P. (María del Sol Porto), Vega, A. (Ana), Trillo, L.V. (Lucía Vilanova), Salas, A. (Antonio), Reyes, S.B. (Susana Beatriz), León, M.C.L. (María Cruz León), Mingorance, Á.N. (Álvaro Navarro), Barrios, X.G. (Xavier Gabaldó), Vergara, E.O. (Eider Oñate), Torre, A.C. (Andrés Concha), Vivanco, A. (Ana), Fernández, R. (Reyes), Sánchez, F.G. (Francisco Giménez), Forte, M.S. (Miguel Sánchez), Rojo, P. (Pablo), Contreras, J.R. (J. Ruiz), Palacios, A. (Alba), Ibarrondo, C.E. (Cristina Epalza), Cooke, E.F. (Elizabeth Fernández), Navarro, M. (Marisa), Álvarez, C.Á. (Cristina Álvarez), Lozano, M.J. (María José), Carreras, E. (Eduardo), Sanagustín, S.B. (Sonia Brió), Neth, O. (Olaf), Padilla, M.C.M. (Ma del Carmen Martínez), Tato, L.M.P. (Luis Manuel Prieto), Guillén, S. (Sara), Silveira, L.F. (Laura Fernández), Moreno, D. (David), van Furth, A.M.T. (A. M. Tutu), Boeddha, N.P. (Navin), Driessen, G.J.A. (Gertjan), Hazelzet, J.A. (Jan), Pajkrt, D. (D.), Sanders, E.A.M. (E. A.M.), van de Beek, D. (D.), Ende, A. (A.) van der, Philipsen, H.L.A. (H. L.A.), Adeel, A.O.A. (A. O.A.), Breukels, M.A. (M. A.), Brinkman, D.M.C., de Korte, C.C.M.M. (C. C.M.M.), de Vries, E. (E.), Waal, W.J. (Wouter) de, Dekkers, R. (R.), Dings-Lammertink, A. (A.), Doedens, R.A. (R. A.), Donker, A.E. (A.), Dousma, M. (M.), Faber, T.E. (T. E.), Gerrit, G.P.J.M. (Gerardus), Gerver, J.A.M. (J. A.M.), Heidema, J. (Jojanneke), Veen, J.H.-V. (J. Homan-van der), Jacobs, M.A.M. (M. A.M.), Jansen, N.J.G. (N. J.G.), Kawczynski, P. (P.), Klucovska, K. (K.), Kneyber, M.C.J. (M. C.J.), Koopman-Keemink, Y. (Yvonne), Langenhorst, V.J. (V. J.), Leusink, J. (J.), Loza, B.F. (Bettina F.), Merth, I.T. (I. T.), Miedema, C.J. (C. J.), Neeleman, C. (C.), Noordzij, J.G. (Jeroen), Obihara, C.C. (Charlie C.), van Overbeek – van Gils, A.L.T. (A. L.T.), Poortman, G.H. (G. H.), Potgieter, S.T. (S. T.), Potjewijd, J. (J.), Rosias, P.P.R. (Philippe), Sprong, T. (Tom), ten Tussher, G.W. (G. W.), Thio, B.J. (B. J.), Tramper-Stranders, G.A. (Gerdien), Deuren, M. (Marcel) van, van der Meer, H. (H.), van Kuppevelt, A.J.M. (A. J.M.), van Wermeskerken, A.M. (A. M.), Verwijs, W.A. (W. A.), Wolfs, T.F.W. (T. F.W.), Agyeman, P. (Philipp), Aebi, C. (Christoph), Berger, C. (Christoph), Giannoni, P., Stocker, M. (Martin), Posfay-Barbe, K.M. (Klara M.), Heininger, U. (Ulrich), Bernhard-Stirnemann, S. (Sara), Niederer-Loher, A. (Anita), Kahlert, C. (Christian), Hasters, P. (Paul), Relly, C. (Christa), Baer, W. (Walter), Frederick, H. (Hannah), Jennings, R. (Rebecca), Johnston, J. (Joanne), Kenwright, R. (Rhian), Pinnock, E. (Elli), Agbeko, R. (Rachel), Secka, F. (Fatou), Bojang, K. (Kalifa), Sarr, I. (Isatou), Kebbeh, N. (Ngange), Sey, G. (Gibbi), Momodou, (), khan, S. (Saidy), Cole, F. (Fatoumata), Thomas, G. (Gilleh), Antonio, M. (Martin), Klobassa, D.S. (Daniela S.), Binder, A. (Alexander), Schweintzger, N.A. (Nina A.), Sagmeister, M. (Manfred), Baumgart, H. (Hinrich), Baumgartner, M. (Markus), Behrends, U. (Uta), Biebl, A. (Ariane), Birnbacher, R. (Robert), Blanke, J.-G. (Jan-Gerd), Boelke, C. (Carsten), Breuling, K. (Kai), Brunner, J. (Jürgen), Buller, M. (Maria), Dahlem, P. (Peter), Dietrich, B. (Beate), Eber, E. (Ernst), Elias, J. (Johannes), Emhofer, J. (Josef), Etschmaier, R. (Rosa), Farr, S. (Sebastian), Girtler, Y. (Ylenia), Grigorow, I. (Irina), Heimann, K. (Konrad), Ihm, U. (Ulrike), Jaros, Z. (Zdenek), Kalhoff, H. (Hermann), Kaulfersch, W. (Wilhelm), Kemen, C. (Christoph), Klocker, N. (Nina), Köster, B. (Bernhard), Kohlmaier, B. (Benno), Komini, E. (Eleni), Kramer, L. (Lydia), Neubert, A. (Antje), Ortner, D. (Daniel), Pescollderungg, L. (Lydia), Pfurtscheller, K. (Klaus), Reiter, K. (Karl), Ristic, G. (Goran), Rödl, S. (Siegfried), Sellner, A. (Andrea), Sonnleitner, A. (Astrid), Sperl, M. (Matthias), Stelzl, W. (Wolfgang), Till, H. (Holger), Trobisch, A. (Andreas), Vierzig, A. (Anne), Vogel, U. (Ulrich), Weingarten, C. (Christina), Welke, S. (Stefanie), Wimmer, A. (Andreas), Wintergerst, U. (Uwe), Wüller, D. (Daniel), Zaunschirm, A. (Andrew), Ziuraite, I. (Ieva), and Žukovskaja, V. (Veslava)

Abstract

Fever is the most common reason that children present to Emergency Departments. Clinical signs and symptoms suggestive of bacterial infection are

Published
2019
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14. Pulmonary exacerbations in patients with primary ciliary dyskinesia: an expert consensus definition for use in clinical trials.

Author

Lucas, JS, Gahleitner, F, Amorim, A, Boon, M, Brown, P, Constant, C, Cook, S, Crowley, S, Destouches, DMS, Eber, E, Mussaffi, H, Haarman, E, Harris, A, Koerner-Rettberg, C, Kuehni, CE, Latzin, P, Loebinger, MR, Lorent, N, Maitre, B, Moreno-Galdó, A, Nielsen, KG, Özçelik, U, Philipsen, LKD, Pohunek, P, Polverino, E, Rademacher, J, Robinson, P, Snijders, D, Yiallouros, P, Carr, SB, Lucas, JS, Gahleitner, F, Amorim, A, Boon, M, Brown, P, Constant, C, Cook, S, Crowley, S, Destouches, DMS, Eber, E, Mussaffi, H, Haarman, E, Harris, A, Koerner-Rettberg, C, Kuehni, CE, Latzin, P, Loebinger, MR, Lorent, N, Maitre, B, Moreno-Galdó, A, Nielsen, KG, Özçelik, U, Philipsen, LKD, Pohunek, P, Polverino, E, Rademacher, J, Robinson, P, Snijders, D, Yiallouros, P, and Carr, SB

Abstract

Pulmonary exacerbations are a cause of significant morbidity in patients with primary ciliary dyskinesia (PCD) and are frequently used as an outcome measure in clinical research into chronic lung diseases. So far, there has been no consensus on the definition of pulmonary exacerbations in PCD. 30 multidisciplinary experts and patients developed a consensus definition for children and adults with PCD. Following a systematic review, the panel used a modified Delphi process with a combination of face-to-face meetings and e-surveys to develop a definition that can be used in research settings for children and adults with PCD. A pulmonary exacerbation was defined by the presence of three or more of the following seven items: 1) increased cough, 2) change in sputum volume and/or colour, 3) increased shortness of breath perceived by the patient or parent, 4) decision to start or change antibiotic treatment because of perceived pulmonary symptoms, 5) malaise, tiredness, fatigue or lethargy, 6) new or increased haemoptysis, and 7) temperature >38°C. The consensus panel proposed that the definition should be used for future clinical trials. The definition should be validated and the usability assessed during these studies.

Published
2019

15. Plasma lipid profiles discriminate bacterial from viral infection in febrile children

Author

Wang, X, Nijman, R, Camuzeaux, S, Sands, C, Jackson, H, Kaforou, M, Emonts, M, Herberg, JA, Maconochie, I, Carrol, ED, Paulus, SC, Zenz, W, Van der Flier, M, de Groot, R, Martinon-Torres, F, Schlapbach, LJ, Pollard, AJ, Fink, C, Kuijpers, TT, Anderson, S, Lewis, MR, Levin, M, McClure, M, Gormley, S, Hamilton, S, Hourmat, B, Hoggart, C, Sancho-Shimizu, V, Wright, V, Abdulla, A, Agapow, P, Bartlett, M, Bellos, E, Eleftherohorinou, H, Galassini, R, Inwald, D, Mashbat, M, Menikou, S, Mustafa, S, Nadel, S, Rahman, R, Thakker, C, Coin, LMJ, Bokhand, S, Power, S, Barham, H, Pathan, N, Ridout, J, White, D, Thurston, S, Faust, S, Patel, S, McCorkell, J, Davies, P, Crate, L, Navarra, H, Carter, S, Ramaiah, R, Patel, R, Tuffrey, C, Gribbin, A, McCready, S, Peters, M, Hardy, K, Standing, F, O'Neill, L, Abelake, E, Deep, A, Nsirim, E, Willis, L, Young, Z, Royad, C, White, S, Fortune, PM, Hudnott, P, Alvez Gonzalez, F, Barral-Arca, R, Cebey-Lopez, M, Jose Curras-Tuala, M, Garcia, N, Garcia Vicente, L, Gomez-Carballa, A, Gomez Rial, J, Grela Beiroa, A, Justicia Grande, A, Leborans Iglesias, P, Martinez Santos, AE, MartinonTorres, N, Martinon Sanchez, JM, Morillo Gutierrez, B, Mosquera Perez, B, Obando Pacheco, P, Pardo-Seco, J, Pischedda, S, RiveroCalle, I, Rodriguez-Tenreiro, C, Redondo-Collazo, L, Salas Ellacuriagal, A, Seren Fernandez, S, Porto Silva, MDS, Vega, A, Vilanova Trillo, L, Salas, A, Beatriz Reyes, S, Leon Leon, MC, Navarro Mingorance, A, Gabaldo Barrios, X, Onate Vergara, E, Concha Torre, A, Vivanco, A, Fernandez, R, Gimenez Sanchez, F, Sanchez Forte, M, Rojo, P, Ruiz Contreras, J, Palacios, A, Epalza Ibarrondo, C, Fernandez Cooke, E, Navarro, M, Alvarez Alvarez, C, Jose Lozano, M, Carreras, E, Brio Sanagustin, S, Neth, O, Martinez Padilla, MDC, Prieto Tato, LM, Guillen, S, Fernandez Silveira, L, Moreno, D, van Furth, AMT, Boeddha, NP, Driessen, GJA, Hazelzet, JA, Pajkrt, D, Sanders, EAM, van de Beek, D, van der Ende, A, Philipsen, HLA, Adeel, AOA, Breukels, MA, Brinkman, DMC, de Korte, CCMM, de Vries, E, de Waal, WJ, Dekkers, R, Dings-Lammertink, A, Doedens, RA, Donker, AE, Dousma, M, Faber, TE, Gerrits, GPJM, Gerver, JAM, Heidema, J, Homan-van der Veen, J, Jacobs, MAM, Jansen, NJG, Kawczynski, P, Klucovska, K, Kneyber, MCJ, Koopman-Keemink, Y, Langenhorst, VJ, Leusink, J, Loza, BF, Merth, IT, Miedema, CJ, Neeleman, C, Noordzij, JG, Obihara, CC, van Overbeek-van Gils, ALT, Poortman, GH, Potgieter, ST, Potjewijd, J, Rosias, PPR, Sprong, T, ten Tussher, GW, Thio, BJ, Tramper-Stranders, GA, van Deuren, M, van der Meer, H, van Kuppevelt, AJM, van Wermeskerken, AM, Verwijs, WA, Wolfs, TFW, Agyeman, P, Aebi, C, Berger, C, Giannoni, E, Stocker, M, Posfay-Barbe, KM, Heininger, U, Bernhard-Stirnemann, S, Niederer-Loher, A, Kahlert, C, Hasters, P, Relly, C, Baer, W, Frederick, H, Jennings, R, Johnston, J, Kenwright, R, Pinnock, E, Agbeko, R, Secka, F, Bojang, K, Sarr, I, Kebbeh, N, Sey, G, Momodou, SK, Cole, F, Thomas, G, Antonio, M, Klobassa, DS, Binder, A, Schweintzger, NA, Sagmeister, M, Baumgart, H, Baumgartner, M, Behrends, U, Biebl, A, Birnbacher, R, Blanke, J-G, Boelke, C, Breuling, K, Brunner, J, Buller, M, Dahlem, P, Dietrich, B, Eber, E, Elias, J, Emhofer, J, Etschmaier, R, Farr, S, Girtler, Y, Grigorow, I, Heimann, K, Ihm, U, Jaros, Z, Kalhoff, H, Kaulfersch, W, Kemen, C, Klocker, N, Koester, B, Kohlmaier, B, Komini, E, Kramer, L, Neubert, A, Ortner, D, Pescollderungg, L, Pfurtscheller, K, Reiter, K, Ristic, G, Roedl, S, Sellner, A, Sonnleitner, A, Sperl, M, Stelzl, W, Till, H, Trobisch, A, Vierzig, A, Vogel, U, Weingarten, C, Welke, S, Wimmer, A, Wintergerst, U, Wueller, D, Zaunschirm, A, Ziuraite, I, Zukovskaja, V, Wang, X, Nijman, R, Camuzeaux, S, Sands, C, Jackson, H, Kaforou, M, Emonts, M, Herberg, JA, Maconochie, I, Carrol, ED, Paulus, SC, Zenz, W, Van der Flier, M, de Groot, R, Martinon-Torres, F, Schlapbach, LJ, Pollard, AJ, Fink, C, Kuijpers, TT, Anderson, S, Lewis, MR, Levin, M, McClure, M, Gormley, S, Hamilton, S, Hourmat, B, Hoggart, C, Sancho-Shimizu, V, Wright, V, Abdulla, A, Agapow, P, Bartlett, M, Bellos, E, Eleftherohorinou, H, Galassini, R, Inwald, D, Mashbat, M, Menikou, S, Mustafa, S, Nadel, S, Rahman, R, Thakker, C, Coin, LMJ, Bokhand, S, Power, S, Barham, H, Pathan, N, Ridout, J, White, D, Thurston, S, Faust, S, Patel, S, McCorkell, J, Davies, P, Crate, L, Navarra, H, Carter, S, Ramaiah, R, Patel, R, Tuffrey, C, Gribbin, A, McCready, S, Peters, M, Hardy, K, Standing, F, O'Neill, L, Abelake, E, Deep, A, Nsirim, E, Willis, L, Young, Z, Royad, C, White, S, Fortune, PM, Hudnott, P, Alvez Gonzalez, F, Barral-Arca, R, Cebey-Lopez, M, Jose Curras-Tuala, M, Garcia, N, Garcia Vicente, L, Gomez-Carballa, A, Gomez Rial, J, Grela Beiroa, A, Justicia Grande, A, Leborans Iglesias, P, Martinez Santos, AE, MartinonTorres, N, Martinon Sanchez, JM, Morillo Gutierrez, B, Mosquera Perez, B, Obando Pacheco, P, Pardo-Seco, J, Pischedda, S, RiveroCalle, I, Rodriguez-Tenreiro, C, Redondo-Collazo, L, Salas Ellacuriagal, A, Seren Fernandez, S, Porto Silva, MDS, Vega, A, Vilanova Trillo, L, Salas, A, Beatriz Reyes, S, Leon Leon, MC, Navarro Mingorance, A, Gabaldo Barrios, X, Onate Vergara, E, Concha Torre, A, Vivanco, A, Fernandez, R, Gimenez Sanchez, F, Sanchez Forte, M, Rojo, P, Ruiz Contreras, J, Palacios, A, Epalza Ibarrondo, C, Fernandez Cooke, E, Navarro, M, Alvarez Alvarez, C, Jose Lozano, M, Carreras, E, Brio Sanagustin, S, Neth, O, Martinez Padilla, MDC, Prieto Tato, LM, Guillen, S, Fernandez Silveira, L, Moreno, D, van Furth, AMT, Boeddha, NP, Driessen, GJA, Hazelzet, JA, Pajkrt, D, Sanders, EAM, van de Beek, D, van der Ende, A, Philipsen, HLA, Adeel, AOA, Breukels, MA, Brinkman, DMC, de Korte, CCMM, de Vries, E, de Waal, WJ, Dekkers, R, Dings-Lammertink, A, Doedens, RA, Donker, AE, Dousma, M, Faber, TE, Gerrits, GPJM, Gerver, JAM, Heidema, J, Homan-van der Veen, J, Jacobs, MAM, Jansen, NJG, Kawczynski, P, Klucovska, K, Kneyber, MCJ, Koopman-Keemink, Y, Langenhorst, VJ, Leusink, J, Loza, BF, Merth, IT, Miedema, CJ, Neeleman, C, Noordzij, JG, Obihara, CC, van Overbeek-van Gils, ALT, Poortman, GH, Potgieter, ST, Potjewijd, J, Rosias, PPR, Sprong, T, ten Tussher, GW, Thio, BJ, Tramper-Stranders, GA, van Deuren, M, van der Meer, H, van Kuppevelt, AJM, van Wermeskerken, AM, Verwijs, WA, Wolfs, TFW, Agyeman, P, Aebi, C, Berger, C, Giannoni, E, Stocker, M, Posfay-Barbe, KM, Heininger, U, Bernhard-Stirnemann, S, Niederer-Loher, A, Kahlert, C, Hasters, P, Relly, C, Baer, W, Frederick, H, Jennings, R, Johnston, J, Kenwright, R, Pinnock, E, Agbeko, R, Secka, F, Bojang, K, Sarr, I, Kebbeh, N, Sey, G, Momodou, SK, Cole, F, Thomas, G, Antonio, M, Klobassa, DS, Binder, A, Schweintzger, NA, Sagmeister, M, Baumgart, H, Baumgartner, M, Behrends, U, Biebl, A, Birnbacher, R, Blanke, J-G, Boelke, C, Breuling, K, Brunner, J, Buller, M, Dahlem, P, Dietrich, B, Eber, E, Elias, J, Emhofer, J, Etschmaier, R, Farr, S, Girtler, Y, Grigorow, I, Heimann, K, Ihm, U, Jaros, Z, Kalhoff, H, Kaulfersch, W, Kemen, C, Klocker, N, Koester, B, Kohlmaier, B, Komini, E, Kramer, L, Neubert, A, Ortner, D, Pescollderungg, L, Pfurtscheller, K, Reiter, K, Ristic, G, Roedl, S, Sellner, A, Sonnleitner, A, Sperl, M, Stelzl, W, Till, H, Trobisch, A, Vierzig, A, Vogel, U, Weingarten, C, Welke, S, Wimmer, A, Wintergerst, U, Wueller, D, Zaunschirm, A, Ziuraite, I, and Zukovskaja, V

Abstract

Fever is the most common reason that children present to Emergency Departments. Clinical signs and symptoms suggestive of bacterial infection are often non-specific, and there is no definitive test for the accurate diagnosis of infection. The 'omics' approaches to identifying biomarkers from the host-response to bacterial infection are promising. In this study, lipidomic analysis was carried out with plasma samples obtained from febrile children with confirmed bacterial infection (n = 20) and confirmed viral infection (n = 20). We show for the first time that bacterial and viral infection produces distinct profile in the host lipidome. Some species of glycerophosphoinositol, sphingomyelin, lysophosphatidylcholine and cholesterol sulfate were higher in the confirmed virus infected group, while some species of fatty acids, glycerophosphocholine, glycerophosphoserine, lactosylceramide and bilirubin were lower in the confirmed virus infected group when compared with confirmed bacterial infected group. A combination of three lipids achieved an area under the receiver operating characteristic (ROC) curve of 0.911 (95% CI 0.81 to 0.98). This pilot study demonstrates the potential of metabolic biomarkers to assist clinicians in distinguishing bacterial from viral infection in febrile children, to facilitate effective clinical management and to the limit inappropriate use of antibiotics.

Published
2019

19. ERS Task Force guideline for the diagnosis of primary ciliary dyskinesia

Author

Lucas, JS, Barbato, A, Collins, SA, Goutaki, M, Behan, L, Caudri, D, Dell, S, Eber, E, Escudier, E, Hirst, RA, Hogg, C, Jorissen, M, Latzin, P, Legendre, M, Leigh, MW, Midulla, F, Nielsen, KG, Omran, H, Papon, JF, Pohunek, P, Redfern, B, Rigau, D, Rindlisbacher, B, Santamaria, F, Shoemark, A, Snijders, D, Tonia, T, Titieni, A, Walker, WT, Werner, C, Bush, A, and Kuehni, CE

Subjects
Microscopy, Video, Delphi Technique, Kartagener Syndrome, Fluorescent Antibody Technique, Nitric Oxide, Article, Diagnosis, Differential, Europe, Review Literature as Topic, Microscopy, Electron, Transmission, Humans, Cilia, Genetic Testing, Societies, Medical
Abstract

The diagnosis of primary ciliary dyskinesia is often confirmed with standard, albeit complex and expensive, tests. In many cases, however, the diagnosis remains difficult despite the array of sophisticated diagnostic tests. There is no "gold standard" reference test. Hence, a Task Force supported by the European Respiratory Society has developed this guideline to provide evidence-based recommendations on diagnostic testing, especially in light of new developments in such tests, and the need for robust diagnoses of patients who might enter randomised controlled trials of treatments. The guideline is based on pre-defined questions relevant for clinical care, a systematic review of the literature, and assessment of the evidence using the GRADE (Grading of Recommendations, Assessment, Development and Evaluation) approach. It focuses on clinical presentation, nasal nitric oxide, analysis of ciliary beat frequency and pattern by high-speed video-microscopy analysis, transmission electron microscopy, genotyping and immunofluorescence. It then used a modified Delphi survey to develop an algorithm for the use of diagnostic tests to definitively confirm and exclude the diagnosis of primary ciliary dyskinesia; and to provide advice when the diagnosis was not conclusive. Finally, this guideline proposes a set of quality criteria for future research on the validity of diagnostic methods for primary ciliary dyskinesia.

Published
2017

20. ERS statement: Interventional bronchoscopy in children

Author

Eber, E. Antón-Pacheco, J.L. de Blic, J. Doull, I. Faro, A. Nenna, R. Nicolai, T. Pohunek, P. Priftis, K.N. Serio, P. Coleman, C. Masefield, S. Tonia, T. Midulla, F.

Abstract

Paediatric airway endoscopy is accepted as a diagnostic and therapeutic procedure, with an expanding number of indications and applications in children. The aim of this European Respiratory Society task force was to produce a statement on interventional bronchoscopy in children, describing the evidence available at present and current clinical practice, and identifying areas deserving further investigation. The multidisciplinary task force panel performed a systematic review of the literature, focusing on whole lung lavage, transbronchial and endobronchial biopsy, transbronchial needle aspiration with endobronchial ultrasound, foreign body extraction, balloon dilation and occlusion, laser-assisted procedures, usage of airway stents, microdebriders, cryotherapy, endoscopic intubation, application of drugs and other liquids, and caregiver perspectives. There is a scarcity of published evidence in this field, and in many cases the task force had to resort to the collective clinical experience of the committee to develop this statement. The highlighted gaps in knowledge underline the need for further research and serve as a call to paediatric bronchoscopists to work together in multicentre collaborations, for the benefit of children with airway disorders. Copyright © ERS 2017

Published
2017

22. Obstruktive Atemwegserkrankungen

Author

Frey U, Gappa M, Eber E, von Mutius E, Barben J, Jürg Hammer, Hamelmann E, Horak E, Schuster A, Hansen G, Seidenberg J, and Modl M

Subjects
Article
Abstract

Zusammenfassung In den folgenden Abschnitten werden die verschiedenen Formen der obstruktiven Atemwegserkrankungen erläutert, die je nach Alter, prädisponierenden Risikofaktoren und auch je nach Art der Auslöser verschiedenartige Ausprägungen und Verlaufsformen (Phänotypen) annehmen können.

Published
2013

23. European Respiratory Society guidelines for the diagnosis of primary ciliary dyskinesia

Author

Lucas, J.S. (Jane S.), Barbato, A. (A.), Collins, S.A. (Samuel A.), Goutaki, M. (Myrofora), Behan, L. (Laura), Caudri, D. (Daan), Dell, S. (Sharon), Eber, E. (Ernst), Escudier, E. (Estelle), Hirst, R.A. (Robert A.), Hogg, C. (Claire), Jorissen, M. (Mark), Latzin, P. (Philipp), Legendre, M. (Marie), Leigh, M.W. (Margaret W.), Midulla, F., Nielsen, K.G. (Kim G.), Omran, H. (Heymut), Papon, J.-F. (Jean-Francois), Pohunek, P. (Petr), Redfern, B. (Beatrice), Rigau, D. (David), Rindlisbacher, B. (Bernhard), Santamaria, F. (Francesca), Shoemark, A. (Amelia), Snijders, D. (Deborah), Tonia, T. (Thomy), Titieni, A. (Andrea), Walker, W.T. (Woolf T.), Werner, C. (Claudius), Bush, A. (Andrew), Kuehni, C. (Claudia), Lucas, J.S. (Jane S.), Barbato, A. (A.), Collins, S.A. (Samuel A.), Goutaki, M. (Myrofora), Behan, L. (Laura), Caudri, D. (Daan), Dell, S. (Sharon), Eber, E. (Ernst), Escudier, E. (Estelle), Hirst, R.A. (Robert A.), Hogg, C. (Claire), Jorissen, M. (Mark), Latzin, P. (Philipp), Legendre, M. (Marie), Leigh, M.W. (Margaret W.), Midulla, F., Nielsen, K.G. (Kim G.), Omran, H. (Heymut), Papon, J.-F. (Jean-Francois), Pohunek, P. (Petr), Redfern, B. (Beatrice), Rigau, D. (David), Rindlisbacher, B. (Bernhard), Santamaria, F. (Francesca), Shoemark, A. (Amelia), Snijders, D. (Deborah), Tonia, T. (Thomy), Titieni, A. (Andrea), Walker, W.T. (Woolf T.), Werner, C. (Claudius), Bush, A. (Andrew), and Kuehni, C. (Claudia)

Abstract

The diagnosis of primary ciliary dyskinesia is often confirmed with standard, albeit complex and expensive, tests. In many cases, however, the diagnosis remains difficult despite the array of sophisticated diagnostic tests. There is no “gold standard” reference test. Hence, a Task Force supported by the European Respiratory Society has developed this guideline to provide evidence-based recommendations on diagnostic testing, especially in light of new developments in such tests, and the need for robust diagnoses of patients who might enter randomised controlled trials of treatments. The guideline is based on pre-defined questions relevant for clinical care, a systematic review of the literature, and assessment of the evidence using the GRADE (Grading of Recommendations, Assessment, Development and Evaluation) approach. It focuses on clinical presentation, nasal nitric oxide, analysis of ciliary beat frequency and pattern by high-speed video-microscopy analysis, transmission electron microscopy, genotyping and immunofluorescence. It then used a modified Delphi survey to develop an algorithm for the use of diagnostic tests to definitively confirm and exclude the diagnosis of primary ciliary dyskinesia; and to provide advice when the diagnosis was not conclusive. Finally, this guideline proposes a set of quality criteria for future research on the validity of diagnostic methods for primary ciliary dyskinesia.

Published
2017
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24. ERS Task Force guideline for the diagnosis of primary ciliary dyskinesia

Author

Lucas, J.S., Barbato, A., Collins, S.A., Goutaki, M., Behan, L., Caudri, D., Eber, E., Escudier, E., Hirst, R.A., Hogg, C., Jorrissen, M., Latzin, P., Legendre, M., Leigh, M.W., Midulla, F., Nielsen, K.G., Omran, H., Papon, J.F., Pohunek, P., Redfern, B., Rigau, D., Rindlisbacher, B., Santamaria, F., Shoemark, A., Snijders, D., Tonia, T., Titeni, A., Walker, W.T, Werner, C., Bush, A., and Keuhni, C.E.

Published
2016

25. Pneumonie und Pleuropneumonie

Author

von Mutius, E, Grappa, M, Eber, E, Frey, U, von Mutius, E ( E ), Grappa, M ( M ), Eber, E ( E ), Frey, U ( U ), Moeller, A, von Mutius, E, Grappa, M, Eber, E, Frey, U, von Mutius, E ( E ), Grappa, M ( M ), Eber, E ( E ), Frey, U ( U ), and Moeller, A

Published
2013

26. Rehabilitation

Author

von Mutius, E, Gappa, M, Eber, E, Frey, U, von Mutius, E ( E ), Gappa, M ( M ), Eber, E ( E ), Frey, U ( U ), Jung, A, Spindler, T, von Mutius, E, Gappa, M, Eber, E, Frey, U, von Mutius, E ( E ), Gappa, M ( M ), Eber, E ( E ), Frey, U ( U ), Jung, A, and Spindler, T

Published
2013

27. Pleuropneumonie

Author

von Mutius, E, Gappa, M, Eber, E, Frey, U, von Mutius, E ( E ), Gappa, M ( M ), Eber, E ( E ), Frey, U ( U ), Berger, C, von Mutius, E, Gappa, M, Eber, E, Frey, U, von Mutius, E ( E ), Gappa, M ( M ), Eber, E ( E ), Frey, U ( U ), and Berger, C

Published
2013

29. Nosokomiale Infektionen der Atemwege

Author

von Mutius, E, Gappa, M, Eber, E, Frey, U, von Mutius, E ( E ), Gappa, M ( M ), Eber, E ( E ), Frey, U ( U ), Berger, C, von Mutius, E, Gappa, M, Eber, E, Frey, U, von Mutius, E ( E ), Gappa, M ( M ), Eber, E ( E ), Frey, U ( U ), and Berger, C

Published
2013

31. Smart Energy Planning in the Midst of a Technological and Political Change towards a 100% Renewable System in Mexico by 2050

Author

Daniel Icaza-Alvarez, Nestor Daniel Galan-Hernandez, Eber Enrique Orozco-Guillen, and Francisco Jurado

Subjects
EnergyPLAN, renewable energy, clean energy, smart energy system, energy planning, Technology
Abstract

This study presents a 100% renewable and diversified system taking advantage of the available energy potential of renewable energies in Mexico with a view to a planned energy transition in cooperation with the environment. The processes of change that are experienced worldwide in favor of the planet make us reflect and propose alternatives that break traditional schemes in the production of energy (for which reason Mexico cannot deviate from its current model). It is here that this research becomes a transcendental and important reference for decision-making and the transformation of the energy sector in Mexico. The current electrical system relies on fossil fuels that need to be replaced by renewable energy sources (and it is necessary to satisfy growing demands in the long term). The methodological process is carried out with the use of the 100% renewable energy market design tool EnergyPLAN, which puts the concept of intelligent energy into practice by 2050. Finally, after analyzing the results, it is concluded that a good energy mix for 2050 is 30% solar photovoltaic, 25% wind, 14.5% hydraulic, 13.8% CSP plants, and 16.7% other technologies. Surpluses may be sold to the United States and Central America through interconnection points.

Published
2023
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32. Paediatrics: Messages from Munich

Author

Midulla, F., Lombardi, E. (Enrico), Pijnenburg, M.W.H. (Mariëlle), Balfour-Lynn, I.M. (Ian M.), Grigg, J. (Jonathan), Bohlin, K. (Kajsa), Rusconi, F. (Franca), Pohunek, P. (Petr), Eber, E. (Ernst), Midulla, F., Lombardi, E. (Enrico), Pijnenburg, M.W.H. (Mariëlle), Balfour-Lynn, I.M. (Ian M.), Grigg, J. (Jonathan), Bohlin, K. (Kajsa), Rusconi, F. (Franca), Pohunek, P. (Petr), and Eber, E. (Ernst)

Abstract

The aim of this article is to describe paediatric highlights from the 2014 European Respiratory Society (ERS) International Congress in Munich, Germany. Abstracts from the seven groups of the ERS Paediatric Assembly (Respiratory Physiology and Sleep, Asthma and Allergy, Cystic Fibrosis, Respiratory Infection and Immunology, Neonatology and Paediatric Intensive Care, Respiratory Epidemiology, and Bronchology) are presented in the context of the current literature.

Published
2015
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35. Paediatrics in Vienna

Author

Midulla, F. Lombardi, E. Carlsen, K.C.L. Regamey, N. Grigg, J. Russell, R.I.R. Turner, S.W. Priftis, K. Eber, E.

Subjects
education
Abstract

The aim of this update is to describe, in the context of the current literature, major papers from the seven groups of the Paediatric Assembly (Respiratory Physiology; Asthma and Allergy; Cystic Fibrosis; Respiratory Infection and Immunology; Neonatology and Paediatric Intensive Care; Respiratory Epidemiology; and Bronchology) presented during the annual European Respiratory Society congress held in 2012 in Vienna, Austria. Copyright ©ERS 2013.

Published
2013

36. Machine Learning Approach to Extract Diagnostic and Prognostic Thresholds: Application in Prognosis of Cardiovascular Mortality

Author

Gladys E. Maestre, Vanessa G. Felix, Eber E. Orozco, Rodolfo Ostos, Luis J. Mena, and Jesus D. Melgarejo

Subjects
Male, medicine.medical_specialty, Medical knowledge, Article Subject, Cardiovascular risk factors, MEDLINE, 030204 cardiovascular system & hematology, lcsh:Computer applications to medicine. Medical informatics, Machine learning, computer.software_genre, Cardiovascular System, Sensitivity and Specificity, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, 0302 clinical medicine, Artificial Intelligence, medicine, Humans, Computer Simulation, Blood pressure monitoring, 030212 general & internal medicine, Medical diagnosis, Aged, Cardiovascular mortality, General Immunology and Microbiology, Extramural, business.industry, Applied Mathematics, Models, Cardiovascular, Reproducibility of Results, Signal Processing, Computer-Assisted, General Medicine, Blood Pressure Monitoring, Ambulatory, Middle Aged, Prognosis, 3. Good health, Cardiovascular Diseases, Modeling and Simulation, lcsh:R858-859.7, Female, Artificial intelligence, Outcomes research, business, computer, Algorithms, Software, Research Article
Abstract

Machine learning has become a powerful tool for analysing medical domains, assessing the importance of clinical parameters, and extracting medical knowledge for outcomes research. In this paper, we present a machine learning method for extracting diagnostic and prognostic thresholds, based on a symbolic classification algorithm called REMED. We evaluated the performance of our method by determining new prognostic thresholds for well-known and potential cardiovascular risk factors that are used to support medical decisions in the prognosis of fatal cardiovascular diseases. Our approach predicted 36% of cardiovascular deaths with 80% specificity and 75% general accuracy. The new method provides an innovative approach that might be useful to support decisions about medical diagnoses and prognoses.

Published
2012
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37. Problematic severe asthma in children, not one problem but many: a GA2LEN initiative

Author

Hedlin, G, Bush, A, Lødrup Carlsen, K, Problematic Severe Asthma in Childhood Initiative group: Baraldi, E, Barbato, A, de Benedictis FM, Boner, Al, Peroni, Diego, Piacentini, Gl, Wilson, N, Carlsen, Kh, De Jongste JC, Eber, E, Pedroletti, C, Malmstrom, K, Melen, E, Papadopoulos, N, Xepapadaki, P, Paton, J, Pedersen, S, Pohunek, P, Roberts, G, and Wennergren, G. .

Subjects
Pulmonary and Respiratory Medicine, Male, medicine.medical_specialty, Adolescent, MEDLINE, Severity of Illness Index, Child, genes, problematic severe asthma, prognosis, NO, Medication Adherence, Severity of illness, Child, genes, problematic severe asthma, prognosis, medicine, Humans, Anti-Asthmatic Agents, Medical prescription, Intensive care medicine, Asthma, business.industry, Inhaler, Nebulizers and Vaporizers, Infant, Newborn, Infant, medicine.disease, Comorbidity, El Niño, Child, Preschool, Physical therapy, Female, business, Psychosocial
Abstract

Although most children with asthma are easy to treat with low doses of safe medications, many remain symptomatic despite every therapeutic effort. The nomenclature regarding this group is confusing, and studies are difficult to compare due to the proliferation of terms describing poorly defined clinical entities. In this review of severe asthma in children, the term problematic severe asthma is used to describe children with any combination of chronic symptoms, acute severe exacerbations and persistent airflow limitation despite the prescription of multiple therapies. The approach to problematic severe asthma may vary with the age of the child, but, in general, three steps need to be taken in order to separate difficult-to-treat from severe therapy-resistant asthma. First, confirmation that the problem is really due to asthma requires a complete diagnostic re-evaluation. Secondly, the paediatrician needs to systematically exclude comorbidity, as well as personal or family psychosocial disorders. The third step is to re-evaluate medication adherence, inhaler technique and the child's environment. There is a clear need for a common international approach, since there is currently no uniform agreement regarding how best to approach children with problematic severe asthma. An essential first step is proper attention to basic care.

Published
2010

38. Factors influencing age at diagnosis of primary ciliary dyskinesia in European children

Author

Kuehni, Claudia E., Frischer, T., Strippoli, M. P. F., Maurer, Elisabeth, Bush, A., Nielsen, Kim G., Escribano, A., Lucas, Jane S., Yiallouros, Panayiotis K., Omran, Heymut, Eber, E., O'Callaghan, C., Snijders, D., Barbato, Angelo, Yiallouros, Panayiotis K. [0000-0002-8339-9285], Kuehni, Claudia E. [0000-0001-8957-2002], Nielsen, Kim G. [0000-0001-5906-9449], and Lucas, Jane S. [0000-0001-8701-9975]

Subjects
Male, Pulmonary and Respiratory Medicine, Pediatrics, medicine.medical_specialty, pediatrics, Adolescent, diagnosis, Cross-sectional study, Epidemiology, Advisory Committees, primary ciliary dyskinesia, Medical and Health Sciences, Primary ciliary dyskinesia, Diagnosis, otorhinolaryngologic diseases, Humans, Medicine, Child, Prospective cohort study, Bronchiectasis, Kartagener syndrome, Kartagener Syndrome, business.industry, Ciliary motility disorders, Health Care Costs, Situs Inversus, medicine.disease, Europe, Situs inversus, Cross-Sectional Studies, El Niño, Mucociliary Clearance, Child, Preschool, primary ciliary dyskinesia, diagnosis, pediatrics, Female, Clinical Medicine, business
Abstract

Primary ciliary dyskinesia (PCD) is a hereditary disorder of mucociliary clearance causing chronic upper and lower airways disease. We determined the number of patients with diagnosed PCD across Europe, described age at diagnosis and determined risk factors for late diagnosis. Centres treating children with PCD in Europe answered questionnaires and provided anonymous patient lists. In total, 223 centres from 26 countries reported 1,009 patients aged

Published
2010
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39. Classification and pharmacological treatment of preschool wheezing: changes since 2008

Author

Brand, P.L.P., Caudri, D., Eber, E., Gaillard, E.A., Garcia-Marcos, L., Hedlin, G., Henderson, J., Kuehni, C.E., Merkus, P.J.F.M., Pedersen, S., Valiulis, A., Wennergren, G., Bush, A., Brand, P.L.P., Caudri, D., Eber, E., Gaillard, E.A., Garcia-Marcos, L., Hedlin, G., Henderson, J., Kuehni, C.E., Merkus, P.J.F.M., Pedersen, S., Valiulis, A., Wennergren, G., and Bush, A.

Abstract

Item does not contain fulltext, Since the publication of the European Respiratory Society Task Force report in 2008, significant new evidence has become available on the classification and management of preschool wheezing disorders. In this report, an international consensus group reviews this new evidence and proposes some modifications to the recommendations made in 2008. Specifically, the consensus group acknowledges that wheeze patterns in young children vary over time and with treatment, rendering the distinction between episodic viral wheeze and multiple-trigger wheeze unclear in many patients. Inhaled corticosteroids remain first-line treatment for multiple-trigger wheeze, but may also be considered in patients with episodic viral wheeze with frequent or severe episodes, or when the clinician suspects that interval symptoms are being under reported. Any controller therapy should be viewed as a treatment trial, with scheduled close follow-up to monitor treatment effect. The group recommends discontinuing treatment if there is no benefit and taking favourable natural history into account when making decisions about long-term therapy. Oral corticosteroids are not indicated in mild-to-moderate acute wheeze episodes and should be reserved for severe exacerbations in hospitalised patients. Future research should focus on better clinical and genetic markers, as well as biomarkers, of disease severity.

Published
2014

40. Primary ciliary dyskinesia (PCD) in Austria

Author

Lesic, Irena, Maurer, Elisabeth, Strippoli, Marie Pierre Francoise, Kuehni, Claudia Elisabeth, Barbato, Angelo, Frischer, Thomas H., Azevedo, I., Baktai, G., De Blic, J., Bush, Andrew P., Carlsen, K-H., Eber, E., Frischer, T., Hesselmar, B., Hogg, C., Jorissen, M., Karadag, B., Kuehni, C. E., Korppi, M., Maurer, E., Minic, P., Nielsen, K.G., Omran, H., Pohunek, P., Priftis, K., Riikjärv, M-A., Petrova Stoyanova, G., Pohanka, V., Snijders, D., Yiallouros, Panayiotis K., and Zivkovic, Z.

Subjects
Situs inversus, Primary ciliary dyskinesia, Epidemiology, Diagnosis, Mucociliary clearance, Therapy, Sinusitis, Clinical Medicine, Medical and Health Sciences, Bronchiectasis
Abstract

INTRODUCTION: Primary ciliary dyskinesia (PCD) is a rare hereditary recessive disease with symptoms of recurrent pneumonia, chronic bronchitis, bronchiectasis, and chronic sinusitis. Chronic rhinitis is often the presenting symptom in newborns and infants. Approximately half of the patients show visceral mirror image arrangements (situs inversus). In this study, we aimed 1) to determine the number of paediatric PCD patients in Austria, 2) to show the diagnostic and therapeutic modalities used in the clinical centres and 3) to describe symptoms of children with PCD. PATIENTS, MATERIAL AND METHODS: For the first two aims, we analysed data from a questionnaire survey of the European Respiratory Society (ERS) task force on Primary Ciliary Dyskinesia in children. All paediatric respiratory units in Austria received a questionnaire. Symptoms of PCD patients from Vienna Children's University Hospital (aim 3) were extracted from case histories. RESULTS: In 13 Austrian clinics 48 patients with PCD (36 aged from 0–19 years) were identified. The prevalence of reported cases (aged 0–19 yrs) in Austria was 1:48000. Median age at diagnosis was 4.8 years (IQR 0.3–8.2), lower in children with situs inversus compared to those without (3.1 vs. 8.1 yrs, p = 0.067). In 2005–2006, the saccharine test was still the most commonly used screening test for PCD in Austria (45%). Confirmation of the diagnosis was usually by electron microscopy (73%). All clinics treated exacerbations immediately with antibiotics, 73% prescribed airway clearance therapy routinely to all patients. Other therapies and diagnostic tests were applied very inconsistently across Austrian hospitals. All PCD patients from Vienna (n = 13) had increased upper and lower respiratory secretions, most had recurring airway infections (n = 12), bronchiectasis (n = 7) and bronchitis (n = 7). CONCLUSION: Diagnosis and therapy of PCD in Austria are inhomogeneous. Prospective studies are needed to learn more about the course of the disease and to evaluate benefits and harms of different treatment strategies.

Published
2009

41. Definition, assessment and treatment of wheezing disorders in preschool children

Author

Brand, Plp, Baraldi, E, Bisgaard, H, Boner, A, CASTRO RODRIGUEZ JA, Custovic, A, DE BLIC, J, DE JONGSTE JC, Eber, E, Everard, Ml, Frey, U, Gappa, M, GARCIA MARCOS, L, Grigg, J, Lenney, W, Lesouef, P, Mckenzie, S, Merkus, Pjfm, Midulla, Fabio, Paton, Jy, Piacentini, G, Pohunek, P, Rossi, G, Seddon, P, Silverman, M, Sly, Pd, Stick, S, Valiulis, A, VAN AALDEREN WMC, Wildhaber, Jh, Wennergren, G, Wilson, N, Zivkovic, Z, and Bush, A.

Published
2008

42. Task force on chronic interstitial lung disease in immunocompetent children

Author

Clement, A., Allen, J., Corrin, B., Dinwiddie, R., Ducou Le Pointe, Eber, E., Laurent, G., Marshall, R., Midulla, Fabio, Nicholson, A. G., Pohunek, P., Ratjen, F., Spiteri, M., and De Blic, J.

Subjects
Male, Pulmonary and Respiratory Medicine, medicine.medical_specialty, Pathology, Adolescent, Health Planning Guidelines, children, infant, interstitial lung disease, lung fibrosis, Immunocompromised Host, Pulmonary fibrosis, medicine, Humans, Child, Intensive care medicine, Societies, Medical, Lung, Heterogeneous group, Task force, business.industry, Respiratory disease, Infant, Newborn, Interstitial lung disease, Infant, Chronic interstitial lung disease, medicine.disease, medicine.anatomical_structure, Child, Preschool, Chronic Disease, Disease Progression, Research studies, Female, Lung Diseases, Interstitial, business
Abstract

Chronic interstitial lung diseases in children represent a heterogeneous group of disorders of both known and unknown causes that share common histological features. Despite many efforts these diseases continue to present clinical management dilemmas, principally because of their rare frequency that limits considerably the possibilities of collecting enough cases for clinical and research studies. Through a Task Force conducted by the European Respiratory Society, which comprised respiratory physicians and basic scientists from across Europe, 185 cases of interstitial lung diseases in immunocompetent children were collected and reviewed. The present report provides important clinically-relevant information on the current approach to diagnosis and management of chronic interstitial lung diseases in children. In addition, recommendations for the management of paediatric interstitial lung diseases, as well as new insights into interstitial lung diseases pathophysiology during childhood are discussed.

Published
2004

43. Paediatrics in Barcelona

Author

Midulla, F., primary, Lombardi, E., additional, Rottier, B., additional, Lindblad, A., additional, Grigg, J., additional, Bohlin, K., additional, Rusconi, F., additional, Pohunek, P., additional, and Eber, E., additional

Published
2014
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45. Partial splenectomy in cystic fibrosis patients with hypersplenism

Author

Thalhammer, G, Eber, E, Uranus, S, Pfeifer, J, Zach, M, Kelly, D, and de Ville, de Goyet J

Subjects
medicine.medical_specialty, Pancreatic disease, business.industry, medicine.medical_treatment, Splenectomy, Accessory spleen, medicine.disease, Cystic fibrosis, Surgery, Liver disease, Pediatrics, Perinatology and Child Health, medicine, Original Article, Splenic disease, Varices, Complication, business
Abstract

We report three cystic fibrosis (CF) patients with hypersplenism who underwent partial splenectomy. The postoperative course was uneventful in two patients; one patient developed a complication necessitating resection of the rest of the spleen. Haematological parameters improved and oesophageal varices regressed in all patients. On follow up, one patient showed a normal spleen, the other a normally functioning accessory spleen; the third patient again developed splenomegaly with hypersplenism. Partial splenectomy is a promising therapeutic option for CF patients with hypersplenism.

Published
2003

46. Kindliche Lunge und körperliche Aktivität

Author

von Mutius, Erika, Gappa, Monika, Eber, Ernst, Frey, Urs, von Mutius, E ( Erika ), Gappa, M ( Monika ), Eber, E ( Ernst ), Frey, U ( Urs ), Kriemler, Susi, von Mutius, Erika, Gappa, Monika, Eber, Ernst, Frey, Urs, von Mutius, E ( Erika ), Gappa, M ( Monika ), Eber, E ( Ernst ), Frey, U ( Urs ), and Kriemler, Susi

Published
2013

48. Chronic cough

Author

Priftis, K. N., Anthracopoulos, M. B., Eber, E., Koumbourlis, A. C., Wood, R. E., Masters, Ian B., Chang, Anne B., Priftis, K. N., Anthracopoulos, M. B., Eber, E., Koumbourlis, A. C., Wood, R. E., Masters, Ian B., and Chang, Anne B.

Published
2010

49. Definition, assessment and treatment of wheezing disorders in preschool children: an evidence-based approach.

Author

Brand, P.L.P., Baraldi, E., Bisgaard, H., Boner, A.L., Castro-Rodriguez, J.A., Custovic, A., Blic, J. de, Jongste, J.C. de, Eber, E., Everard, M.L., Frey, U., Gappa, M., Garcia-Marcos, L., Grigg, J., Lenney, W., Souef, P. Le, McKenzie, S., Merkus, P.J.F.M., Midulla, F., Paton, J.Y., Piacentini, G., Pohunek, P., Rossi, G.A., Seddon, P.C., Silverman, M., Sly, P.D., Stick, S., Valiulis, A., Aalderen, W.M., Wildhaber, J.H., Wennergren, G., Wilson, N., Zivkovic, Z., Bush, A., Brand, P.L.P., Baraldi, E., Bisgaard, H., Boner, A.L., Castro-Rodriguez, J.A., Custovic, A., Blic, J. de, Jongste, J.C. de, Eber, E., Everard, M.L., Frey, U., Gappa, M., Garcia-Marcos, L., Grigg, J., Lenney, W., Souef, P. Le, McKenzie, S., Merkus, P.J.F.M., Midulla, F., Paton, J.Y., Piacentini, G., Pohunek, P., Rossi, G.A., Seddon, P.C., Silverman, M., Sly, P.D., Stick, S., Valiulis, A., Aalderen, W.M., Wildhaber, J.H., Wennergren, G., Wilson, N., Zivkovic, Z., and Bush, A.

Abstract

Contains fulltext : 69668.pdf (publisher's version ) (Closed access), There is poor agreement on definitions of different phenotypes of preschool wheezing disorders. The present Task Force proposes to use the terms episodic (viral) wheeze to describe children who wheeze intermittently and are well between episodes, and multiple-trigger wheeze for children who wheeze both during and outside discrete episodes. Investigations are only needed when in doubt about the diagnosis. Based on the limited evidence available, inhaled short-acting beta(2)-agonists by metered-dose inhaler/spacer combination are recommended for symptomatic relief. Educating parents regarding causative factors and treatment is useful. Exposure to tobacco smoke should be avoided; allergen avoidance may be considered when sensitisation has been established. Maintenance treatment with inhaled corticosteroids is recommended for multiple-trigger wheeze; benefits are often small. Montelukast is recommended for the treatment of episodic (viral) wheeze and can be started when symptoms of a viral cold develop. Given the large overlap in phenotypes, and the fact that patients can move from one phenotype to another, inhaled corticosteroids and montelukast may be considered on a trial basis in almost any preschool child with recurrent wheeze, but should be discontinued if there is no clear clinical benefit. Large well-designed randomised controlled trials with clear descriptions of patients are needed to improve the present recommendations on the treatment of these common syndromes.

Published
2008

50. Definition, assessment and treatment of wheezing disorders in preschool children: an evidence-based approach

Author

Brand, P.L., Baraldi, E., Bisgaard, H., Boner, A.L., Castro-Rodriguez, J.A., Custovic, A., de, Blic J., Jongste, J.C. de, Eber, E., Everard, M.L., Frey, U., Gappa, M., Garcia-Marcos, L., Grigg, J., Lenney, W., Le, Souef P., McKenzie, S., Merkus, P.J., Midulla, F., Paton, J.Y., Piacentini, G., Pohunek, P., Rossi, G.A., Seddon, P., Silverman, M., Sly, P.D., Stick, S., Valiulis, A., Aalderen, W.M. van, Wildhaber, J.H., Wennergren, G., Wilson, N., Zivkovic, Z., Bush, A., Brand, P.L., Baraldi, E., Bisgaard, H., Boner, A.L., Castro-Rodriguez, J.A., Custovic, A., de, Blic J., Jongste, J.C. de, Eber, E., Everard, M.L., Frey, U., Gappa, M., Garcia-Marcos, L., Grigg, J., Lenney, W., Le, Souef P., McKenzie, S., Merkus, P.J., Midulla, F., Paton, J.Y., Piacentini, G., Pohunek, P., Rossi, G.A., Seddon, P., Silverman, M., Sly, P.D., Stick, S., Valiulis, A., Aalderen, W.M. van, Wildhaber, J.H., Wennergren, G., Wilson, N., Zivkovic, Z., and Bush, A.

Abstract

There is poor agreement on definitions of different phenotypes of preschool wheezing disorders. The present Task Force proposes to use the terms episodic (viral) wheeze to describe children who wheeze intermittently and are well between episodes, and multiple-trigger wheeze for children who wheeze both during and outside discrete episodes. Investigations are only needed when in doubt about the diagnosis. Based on the limited evidence available, inhaled short-acting beta(2)-agonists by metered-dose inhaler/spacer combination are recommended for symptomatic relief. Educating parents regarding causative factors and treatment is useful. Exposure to tobacco smoke should be avoided; allergen avoidance may be considered when sensitisation has been established. Maintenance treatment with inhaled corticosteroids is recommended for multiple-trigger wheeze; benefits are often small. Montelukast is recommended for the treatment of episodic (viral) wheeze and can be started when symptoms of a viral cold develop. Given the large overlap in phenotypes, and the fact that patients can move from one phenotype to another, inhaled corticosteroids and montelukast may be considered on a trial basis in almost any preschool child with recurrent wheeze, but should be discontinued if there is no clear clinical benefit. Large well-designed randomised controlled trials with clear descriptions of patients are needed to improve the present recommendations on the treatment of these common syndromes Udgivelsesdato: 2008/10

Published
2008

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