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Reading newly-published papers in time is important for researchers since these papers provide the latest research findings. However, it is challenging to retrieve newly-published papers through common query-based search engines because the papers lacking sufficient citations and links are usually ranked too low in the search list. To this end, we design a time-aware joint model to infer users’ preference for the newly-published papers with the help of subsidiary relations of social and article linkages. The temporal preference of researchers for articles is jointly modeled with social and article relations by a group of matrices sharing common dimensions of researchers and articles. A joint multi-relational factorization algorithm is devised to approximate the latent factor matrices along with a temporal recommendation algorithm to predict the personalized new referential papers based on the factor matrices. The experimental results on real-world datasets show that the proposed model outperforms the state-of-the-art methods.

Ipilimumab is a monoclonal antibody directed against CTLA4 T-lymphocyte antigen used as cancer therapy. Immune-related adverse events are common side effects and may include hypophysitis-related hypopituitarism. The clinical features of six patients with ipilimumab-induced hypophysitis (IH) are described. The clinical features of IH reported in clinical trials, including the incidence of IH by gender and the likelihood of adrenal axis recovery, are summarized. Following the development of IH, most patients remain on glucocorticoid replacement despite efforts to withdraw therapy. Analysis of gender information in published clinical trials suggests that men are more prone to developing IH than women, and few patients fully recover the pituitary-adrenal axis function. Ipilimumab and other drugs within its class are likely to be used to treat many forms of cancer. Endocrinologists should anticipate a significant increase in the incidence of autoimmune hypophysitis. Strategies for early detection of IH and long-term management should be considered.

Systemic corticosteroids play an integral role in the management of many inflammatory and immunologic conditions, but these agents are also associated with serious risks. Osteoporosis, adrenal suppression, hyperglycemia, dyslipidemia, cardiovascular disease, Cushing's syndrome, psychiatric disturbances and immunosuppression are among the more serious side effects noted with systemic corticosteroid therapy, particularly when used at high doses for prolonged periods. This comprehensive article reviews these adverse events and provides practical recommendations for their prevention and management based on both current literature and the clinical experience of the authors.