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1. Multimodal Guided Self-Help Exercise Program to Prevent Speech, Swallowing, and Shoulder Problems Among Head and Neck Cancer Patients: A Feasibility Study

Author

Cnossen, Ingrid C, van Uden-Kraan, Cornelia F, Rinkel, Rico NPM, Aalders, IJke J, de Goede, Cees JT, de Bree, Remco, Doornaert, Patricia, Rietveld, Derek HF, Langendijk, Johannes A, Witte, Birgit I, Leemans, C Rene, and Verdonck-de Leeuw, Irma M

Subjects
Computer applications to medicine. Medical informatics, R858-859.7, Public aspects of medicine, RA1-1270
Abstract

BackgroundDuring a 6-week course of (chemo)radiation many head and neck cancer patients have to endure radiotherapy-induced toxicity, negatively affecting patients’ quality of life. Pretreatment counseling combined with self-help exercises could be provided to inform patients and possibly prevent them from having speech, swallowing, and shoulder problems during and after treatment. ObjectiveOur goal was to investigate the feasibility of a multimodal guided self-help exercise program entitled Head Matters during (chemo)radiation in head and neck cancer patients. MethodsHead and neck cancer patients treated with primary (chemo)radiation or after surgery were asked to perform Head Matters at home. This prophylactic exercise program, offered in three different formats, aims to reduce the risk of developing speech, swallowing, shoulder problems, and a stiff neck. Weekly coaching was provided by a speech and swallowing therapist. Patients filled out a diary to keep track of their exercise activity. To gain insight into possible barriers and facilitators to exercise adherence, reports of weekly coaching sessions were analyzed by 2 coders independently. ResultsOf 41 eligible patients, 34 patients were willing to participate (83% uptake). Of participating patients, 21 patients completed the program (64% adherence rate). The majority of participants (58%) had a moderate to high level of exercise performance. Exercise performance level was not significantly associated with age (P=.50), gender (P=.42), tumor subsite (P=1.00) or tumor stage (P=.20), treatment modality (P=.72), or Head Matters format (Web-based or paper) (P=1.00). Based on patients’ diaries and weekly coaching sessions, patients’ perceived barriers to exercise were a decreased physical condition, treatment-related barriers, emotional problems, lack of motivation, social barriers, and technical problems. Patients’ perceived facilitators included an increased physical condition, feeling motivated, and social and technical facilitators. ConclusionsHead Matters, a multimodal guided self-help exercise program is feasible for head and neck cancer patients undergoing (chemo)radiation. Several barriers (decreased physical condition, treatment-related barriers) and facilitators (increased physical condition, feeling motivated) were identified providing directions for future studies. The next step is conducting a study investigating the (cost-)effectiveness of Head Matters on speech, swallowing, shoulder function, and quality of life.

Published
2014
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4. Patient-derived head and neck cancer organoids allow treatment stratification and serve as a tool for biomarker validation and identification

Author

Millen, Rosemary, De Kort, Willem W.B., Koomen, Mandy, van Son, Gijs J.F., Gobits, Roán, Penning de Vries, Bas, Begthel, Harry, Zandvliet, Maurice, Doornaert, Patricia, Raaijmakers, Cornelis P.J., Geurts, Maarten H., Elias, Sjoerd G., van Es, Robert J.J., de Bree, Remco, Devriese, Lot A., Willems, Stefan M., Kranenburg, Onno, Driehuis, Else, and Clevers, Hans

Published
2023
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6. Online adaptive MR-guided radiotherapy: Conformity of contour adaptation for prostate cancer, rectal cancer and lymph node oligometastases among radiation therapists and radiation oncologists

Author

Rasing, Marnix J.A., Sikkes, Gonda G., Vissers, Nicole G.P.M., Kotte, Alexis N.T.J., Boudewijn, Joske H., Doornaert, Patricia A.H., Eppinga, Wietse S.C., Intven, Martijn, Rutgers, Reijer H.A., Scheeren, Annick, Snoeren, Louk M.W., Vlig, Tiny B., van der Voort van Zyp, Jochem R.N., Wijkhuizen, Lisa M., van Rossum, Peter S.N., Peters, Max, and Jürgenliemk-Schulz, Ina M.

Published
2022
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9. Detectability and intra-fraction motion of individual elective lymph nodes in head and neck cancer patients on the Magnetic Resonance Image guided linear accelerator

Author

Onderzoek Radiotherapie, MS Radiotherapie, Cancer, Radiotherapie, Experimentele klinische fysica, Klinische Fysica RT, Reinders, Floris C.J., de Ridder, Mischa, Stijnman, Peter R.S., Doornaert, Patricia A.H., Raaijmakers, Cornelis P.J., Philippens, Marielle E.P., Onderzoek Radiotherapie, MS Radiotherapie, Cancer, Radiotherapie, Experimentele klinische fysica, Klinische Fysica RT, Reinders, Floris C.J., de Ridder, Mischa, Stijnman, Peter R.S., Doornaert, Patricia A.H., Raaijmakers, Cornelis P.J., and Philippens, Marielle E.P.

Published
2024

10. Magnetic Resonance-based Response Assessment and Dose Adaptation in Human Papilloma Virus Positive Tumors of the Oropharynx treated with Radiotherapy (MR-ADAPTOR): An R-IDEAL stage 2a-2b/Bayesian phase II trial

Author

Bahig, Houda, Yuan, Ying, Mohamed, Abdallah S.R., Brock, Kristy K., Ng, Sweet Ping, Wang, Jihong, Ding, Yao, Hutcheson, Kate, McCulloch, Molly, Balter, Peter A., Lai, Stephen Y., Al-Mamgani, Abrahim, Sonke, Jan-Jakob, van der Heide, Uulke A., Nutting, Christopher, Li, X. Allen, Robbins, Jared, Awan, Mussadiq, Karam, Irene, Newbold, Katherine, Harrington, Kevin, Oelfke, Uwe, Bhide, Shreerang, Philippens, Marielle E.P., Terhaard, Chris H.J., McPartlin, Andrew J., Blanchard, Pierre, Garden, Adam S., Rosenthal, David I., Gunn, Gary B., Phan, Jack, Cazoulat, Guillaume, Aristophanous, Michalis, McSpadden, Kelli K., Garcia, John A., van den Berg, Cornelis A.T., Raaijmakers, Cornelis P.J., Kerkmeijer, Linda, Doornaert, Patricia, Blinde, Sanne, Frank, Steven J., and Fuller, Clifton D.

Published
2018
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11. Comprehensive Quantitative Evaluation of Variability in Magnetic Resonance-Guided Delineation of Oropharyngeal Gross Tumor Volumes and High-Risk Clinical Target Volumes: An R-IDEAL Stage 0 Prospective Study

Author

Cardenas, Carlos E., Blinde, Sanne E., Mohamed, Abdallah S. R., Ng, Sweet Ping, Raaijmakers, Cornelis, Philippens, Marielle, Kotte, Alexis, Al-Mamgani, Abrahim A., Karam, Irene, Thomson, David J., Robbins, Jared, Newbold, Kate, Fuller, Clifton D., Terhaard, Chris, Bahig, Houda, Blanchard, Pierre, Dehnad, Homan, Doornaert, Patricia, Elhalawani, Hesham, Frank, Steven J., Garden, Adam, Gunn, G. Brandon, Hamming-Vrieze, Olga, Kamal, Mona, Kasperts, Nicolien, Lee, Lip Wai, McDonald, Brigid A., McPartlin, Andrew, Meheissen, Mohamed AM, Morrison, William H., Navran, Arash, Nutting, Christopher M., Pameijer, Frank, Phan, Jack, Poon, Ian, Rosenthal, David I, Smid, Ernst J., and Sykes, Andrew J.

Subjects
Observer Variation, Cancer Research, Magnetic Resonance Spectroscopy, Radiation, Radiotherapy Planning, Computer-Assisted, Magnetic Resonance Imaging, Article, Tumor Burden, Oropharyngeal Neoplasms, Oncology, Head and Neck Neoplasms, Humans, Radiology, Nuclear Medicine and imaging, Prospective Studies, Retrospective Studies
Abstract

Tumor and target volume manual delineation remains a challenging task in head and neck cancer radiation therapy. The purpose of this study was to conduct a multi-institutional evaluation of manual delineations of gross tumor volume (GTV), high-risk clinical target volume (CTV), parotids, and submandibular glands on treatment simulation magnetic resonance scans of patients with oropharyngeal cancer.We retrospectively collected pretreatment T1-weighted, T1-weighted with gadolinium contrast, and T2-weighted magnetic resonance imaging scans for 4 patients with oropharyngeal cancer under an institution review board-approved protocol. We provided the scans to 26 radiation oncologists from 7 international cancer centers that participated in this delineation study. We also provide the patients' clinical history and physical examination findings, along with a medical photographic image and radiologic results. We used both the Simultaneous Truth and Performance Level Estimation algorithm and pair-wise comparisons of the contours, using overlap/distance metrics. Lastly, to assess experience and CTV delineation institutional practices, we had participants complete a brief questionnaire.Large variability was measured between observers' delineations for GTVs and CTVs. The mean Dice similarity coefficient values across all physicians' delineations for GTVp, GTVn, CTVp, and CTVn were 0.77, 0.67, 0.77, and 0.69, respectively, for Simultaneous Truth and Performance Level Estimation algorithm comparison, and 0.67, 0.60, 0.67, and 0.58, respectively, for pair-wise analysis. Normal tissue contours were defined more consistently when considering overlap/distance metrics. The median radiation oncology clinical experience was 7 years. The median experience delineating on magnetic resonance imaging was 3.5 years. The GTV-to-CTV margin used was 10 mm for 6 of 7 participant institutions. One institution used 8 mm, and 3 participants (from 3 different institutions) used a margin of 5 mm.The data from this study suggests that appropriate guidelines, contouring quality assurance sessions, and training are still needed for the adoption of magnetic resonance-based treatment planning for head and neck cancers. Such efforts should play a critical role in reducing delineation variation and ensure standardization of target design across clinical practices.

Published
2022

12. Patient-derived head and neck cancer organoids allow treatment stratification and serve as a tool for biomarker validation and identification

Author

Interne geneeskunde GD, CS_Cancer, Millen, Rosemary, De Kort, Willem W B, Koomen, Mandy, van Son, Gijs J F, Gobits, Roán, Penning de Vries, Bas, Begthel, Harry, Zandvliet, Maurice, Doornaert, Patricia, Raaijmakers, Cornelis P J, Geurts, Maarten H, Elias, Sjoerd G, van Es, Robert J J, de Bree, Remco, Devriese, Lot A, Willems, Stefan M, Kranenburg, Onno, Driehuis, Else, Clevers, Hans, Interne geneeskunde GD, CS_Cancer, Millen, Rosemary, De Kort, Willem W B, Koomen, Mandy, van Son, Gijs J F, Gobits, Roán, Penning de Vries, Bas, Begthel, Harry, Zandvliet, Maurice, Doornaert, Patricia, Raaijmakers, Cornelis P J, Geurts, Maarten H, Elias, Sjoerd G, van Es, Robert J J, de Bree, Remco, Devriese, Lot A, Willems, Stefan M, Kranenburg, Onno, Driehuis, Else, and Clevers, Hans

Published
2023

13. Patient-derived head and neck cancer organoids allow treatment stratification and serve as a tool for biomarker validation and identification

Author

MKA/BT Onderzoek, Pathologie Groep Brosens, Epi Kanker Team C, MS Radiotherapie, Cancer, Klinische Fysica RT, JC onderzoeksprogramma Kanker, DHS 3D Lab, MS Hoofd-Hals Chirurgische Oncologie, MS Medische Oncologie, Pathologie Pathologen staf, Lab Translational Oncology, Regenerative Medicine and Stem Cells, CMM, Hubrecht Institute with UMC, Millen, Rosemary, De Kort, Willem W.B., Koomen, Mandy, van Son, Gijs J.F., Gobits, Roán, Penning de Vries, Bas, Begthel, Harry, Zandvliet, Maurice, Doornaert, Patricia, Raaijmakers, Cornelis P.J., Geurts, Maarten H., Elias, Sjoerd G., van Es, Robert J.J., de Bree, Remco, Devriese, Lot A., Willems, Stefan M., Kranenburg, Onno, Driehuis, Else, Clevers, Hans, MKA/BT Onderzoek, Pathologie Groep Brosens, Epi Kanker Team C, MS Radiotherapie, Cancer, Klinische Fysica RT, JC onderzoeksprogramma Kanker, DHS 3D Lab, MS Hoofd-Hals Chirurgische Oncologie, MS Medische Oncologie, Pathologie Pathologen staf, Lab Translational Oncology, Regenerative Medicine and Stem Cells, CMM, Hubrecht Institute with UMC, Millen, Rosemary, De Kort, Willem W.B., Koomen, Mandy, van Son, Gijs J.F., Gobits, Roán, Penning de Vries, Bas, Begthel, Harry, Zandvliet, Maurice, Doornaert, Patricia, Raaijmakers, Cornelis P.J., Geurts, Maarten H., Elias, Sjoerd G., van Es, Robert J.J., de Bree, Remco, Devriese, Lot A., Willems, Stefan M., Kranenburg, Onno, Driehuis, Else, and Clevers, Hans

Published
2023

14. Oncological outcome of vocal cord-only radiotherapy for cT1-T2 glottic laryngeal squamous cell carcinoma

Author

MS Radiotherapie, Cancer, MS Hoofd-Hals Chirurgische Oncologie, MS KNO, Radiotherapie, Fysica Radiotherapie Research, de Ridder, Mischa, Rijken, Johannes A., Smits, Hilde J.G., Smid, Ernst J., Doornaert, Patricia A.H., de Bree, Remco, MS Radiotherapie, Cancer, MS Hoofd-Hals Chirurgische Oncologie, MS KNO, Radiotherapie, Fysica Radiotherapie Research, de Ridder, Mischa, Rijken, Johannes A., Smits, Hilde J.G., Smid, Ernst J., Doornaert, Patricia A.H., and de Bree, Remco

Published
2023

15. Individual elective lymph node irradiation for the reduction of complications in head and neck cancer patients (iNode): A phase-I feasibility trial protocol

Author

Onderzoek Radiotherapie, MS Radiotherapie, Cancer, Klinische Fysica RT, Reinders, Floris C.J., de Ridder, Mischa, Doornaert, Patricia A.H., P.J. Raaijmakers, Cornelis, Philippens, Marielle E.P., Onderzoek Radiotherapie, MS Radiotherapie, Cancer, Klinische Fysica RT, Reinders, Floris C.J., de Ridder, Mischa, Doornaert, Patricia A.H., P.J. Raaijmakers, Cornelis, and Philippens, Marielle E.P.

Published
2023

18. MRI visibility and displacement of elective lymph nodes during radiotherapy in head and neck cancer patients

Author

Onderzoek Radiotherapie, Experimentele klinische fysica, MS Radiotherapie, Cancer, Klinische Fysica RT, Reinders, Floris C J, Stijnman, Peter R S, de Ridder, Mischa, Doornaert, Patricia A H, Raaijmakers, Cornelis P J, Philippens, Marielle E P, Onderzoek Radiotherapie, Experimentele klinische fysica, MS Radiotherapie, Cancer, Klinische Fysica RT, Reinders, Floris C J, Stijnman, Peter R S, de Ridder, Mischa, Doornaert, Patricia A H, Raaijmakers, Cornelis P J, and Philippens, Marielle E P

Published
2022

19. Online adaptive MR-guided radiotherapy: Conformity of contour adaptation for prostate cancer, rectal cancer and lymph node oligometastases among radiation therapists and radiation oncologists

Author

Onderzoek Radiotherapie, Cancer, Klinische Fysica RT, MS Radiotherapie, Arts-assistenten Radiotherapie, Rasing, Marnix J A, Sikkes, Gonda G, Vissers, Nicole G P M, Kotte, Alexis N T J, Boudewijn, Joske H, Doornaert, Patricia A H, Eppinga, Wietse S C, Intven, Martijn, Rutgers, Reijer H A, Scheeren, Annick, Snoeren, Louk M W, Vlig, Tiny B, van der Voort van Zyp, Jochem R N, Wijkhuizen, Lisa M, van Rossum, Peter S N, Peters, Max, Jürgenliemk-Schulz, Ina M, Onderzoek Radiotherapie, Cancer, Klinische Fysica RT, MS Radiotherapie, Arts-assistenten Radiotherapie, Rasing, Marnix J A, Sikkes, Gonda G, Vissers, Nicole G P M, Kotte, Alexis N T J, Boudewijn, Joske H, Doornaert, Patricia A H, Eppinga, Wietse S C, Intven, Martijn, Rutgers, Reijer H A, Scheeren, Annick, Snoeren, Louk M W, Vlig, Tiny B, van der Voort van Zyp, Jochem R N, Wijkhuizen, Lisa M, van Rossum, Peter S N, Peters, Max, and Jürgenliemk-Schulz, Ina M

Published
2022

20. Target Definition in MR-Guided Adaptive Radiotherapy for Head and Neck Cancer

Author

MS Radiotherapie, Cancer, Klinische Fysica RT, MS Radiologie, MS Hoofd-Hals Chirurgische Oncologie, Onderzoek Radiotherapie, Ridder, Mischa de, Raaijmakers, Cornelis P J, Pameijer, Frank A, Bree, Remco de, Reinders, Floris C J, Doornaert, Patricia A H, Terhaard, Chris H J, Philippens, Marielle E P, MS Radiotherapie, Cancer, Klinische Fysica RT, MS Radiologie, MS Hoofd-Hals Chirurgische Oncologie, Onderzoek Radiotherapie, Ridder, Mischa de, Raaijmakers, Cornelis P J, Pameijer, Frank A, Bree, Remco de, Reinders, Floris C J, Doornaert, Patricia A H, Terhaard, Chris H J, and Philippens, Marielle E P

Published
2022

21. Association of histological features with laryngeal squamous cell carcinoma recurrences: a population-based study of 1502 patients in the Netherlands

Author

Fysica Radiotherapie Research, Cancer, MS Radiotherapie, Klinische Fysica RT, MS Hoofd-Hals Chirurgische Oncologie, Epi Kanker Team A, JC onderzoeksprogramma Kanker, Pathologie Pathologen staf, Ruiter, Lilian N, van Dijk, Boukje A C, Bruggink, Annette H, Doornaert, Patricia A H, Philippens, Marielle E P, de Bree, Remco, van Gils, Carla H, Willems, Stefan M, Fysica Radiotherapie Research, Cancer, MS Radiotherapie, Klinische Fysica RT, MS Hoofd-Hals Chirurgische Oncologie, Epi Kanker Team A, JC onderzoeksprogramma Kanker, Pathologie Pathologen staf, Ruiter, Lilian N, van Dijk, Boukje A C, Bruggink, Annette H, Doornaert, Patricia A H, Philippens, Marielle E P, de Bree, Remco, van Gils, Carla H, and Willems, Stefan M

Published
2022

22. Additional file 1 of Association of histological features with laryngeal squamous cell carcinoma recurrences: a population-based study of 1502 patients in the Netherlands

Author

Ruiter, Lilian N., van Dijk, Boukje A. C., Bruggink, Annette H., Doornaert, Patricia A. H., Philippens, Marielle E. P., de Bree, Remco, van Gils, Carla H., and Willems, Stefan M.

Abstract

Additional file 1: Supplementary Table 1. Generalizability sample of pathology data extracted from pathology reports compared to initial cohort. A). Basic clinical characteristics of patients for each year of the sample used in this paper (n = 1502). These are the 3656 patients of which 44% of each year pathology data were extracted and CIS were removed. B). Basic clinical characteristics of the total dataset of patients for each year (n = 3380). These are the 3656 patients with reliable linkage between NKR-PALGA minus 276 CIS patients leaving 3380 patients in total. Supplementary Table 2. Histological characteristics, locoregional recurrences and death of patients treated with tumor-positive lymph nodes (n = 205). Supplementary Table 3. Histological characteristics, locoregional recurrences and death of T3/T4 N0/N+ patients treated with TLE or TLE with RT (n = 98). Supplementary Figure 1. Separate multivariable analysis of extracapsular spread, keratinization and PNI+/VI+/Growth pattern. Each separate histological characteristic was corrected for age, gender, sublocalisation and stage/treatment for locoregional recurrence and death of patients with positive lymph nodes (n = 205). Supplementary Figure 2. Univariable analysis of histological characteristics of the primary tumor for locoregional recurrence and death of T3/T4 N0/N+ patients treated with TLE or TLE with RT (n = 98). * p

Published
2022
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23. National Protocol for Model-Based Selection for Proton Therapy in Head and Neck Cancer

Author

Langendijk, Johannes A., primary, Hoebers, Frank J. P., additional, de Jong, Martin A., additional, Doornaert, Patricia, additional, Terhaard, Chris H. J., additional, Steenbakkers, Roel J. H. M., additional, Hamming-Vrieze, Olga, additional, van de Kamer, Jeroen B., additional, Verbakel, Wilko F. A. R., additional, Keskin-Cambay, Fatma, additional, Reitsma, Johannes B., additional, van der Schaaf, Arjen, additional, Boersma, Liesbeth J., additional, and Schuit, Ewoud, additional

Published
2021
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24. Cost-utility and cost-effectiveness of a guided self-help head and neck exercise program for patients treated with total laryngectomy:Results of a multi-center randomized controlled trial

Author

Jansen, Femke, Coupé, Veerle M.H., Eerenstein, Simone E.J., Cnossen, Ingrid C., van Uden-Kraan, Cornelia F., de Bree, Remco, Doornaert, Patricia, Halmos, György B., Hardillo, José A.U., van Hinte, Gerben, Honings, Jimmie, Leemans, C. René, Verdonck-de Leeuw, Irma M., Jansen, Femke, Coupé, Veerle M.H., Eerenstein, Simone E.J., Cnossen, Ingrid C., van Uden-Kraan, Cornelia F., de Bree, Remco, Doornaert, Patricia, Halmos, György B., Hardillo, José A.U., van Hinte, Gerben, Honings, Jimmie, Leemans, C. René, and Verdonck-de Leeuw, Irma M.

Abstract

Objectives: The guided self-help exercise program called In Tune without Cords (ITwC) is effective in improving swallowing problems and communication among patients treated with a total laryngectomy (TL). This study investigated the cost-utility and cost-effectiveness of ITwC. Materials and methods: Patients within 5 years after TL were included in this randomized controlled trial. Patients in the intervention group (n = 46) received access to the self-help exercise program with flexibility, range-of-motion and lymphedema exercises, and a self-care education program. Patients in the control group (n = 46) received access to the self-care education program only. Healthcare utilization (iMCQ), productivity losses (iPCQ), health status (EQ-5D-3L, EORTC QLU-C10D) and swallowing problems (SwalQol) were measured at baseline, 3- and 6-months follow-up. Hospital costs were extracted from medical files. Mean total costs and effects (quality-adjusted life-years (QALYs) or SwalQol score) were compared with regression analyses using bias-corrected accelerated bootstrapping. Results: Mean total costs were non-significantly lower (-€685) and QALYs were significantly higher (+0.06) in the intervention compared to the control group. The probability that the intervention is less costly and more effective was 73%. Sensitivity analyses with adjustment for baseline costs and EQ-5D scores showed non-significantly higher costs (+€119 to +€364) and QALYs (+0.02 to +0.03). A sensitivity analysis using the QLU-C10D to calculate QALYs showed higher costs (+€741) and lower QALYs (-0.01) and an analysis that used the SwalQol showed higher costs (+€232) and higher effects (improvement of 6 points on a 0–100 scale). Conclusion: ITwC is likely to be effective, but possibly at higher expenses. Trial Registration: NTR5255.

Published
2021

25. National protocol for model-based selection for proton therapy in head and neck cancer

Author

Langendijk, Johannes A., Hoebers, Frank J.P., De Jong, Martin A., Doornaert, Patricia, Terhaard, Chris H.J., Steenbakkers, Roel J.H.M., Hamming-Vrieze, Olga, Van De Kamer, Jeroen B., Verbakel, Wilko F.A.R., Keskin-Cambay, Fatma, Reitsma, Johannes B., Van Der Schaaf, Arjen, Boersma, Liesbeth J., Schuit, Ewoud, Langendijk, Johannes A., Hoebers, Frank J.P., De Jong, Martin A., Doornaert, Patricia, Terhaard, Chris H.J., Steenbakkers, Roel J.H.M., Hamming-Vrieze, Olga, Van De Kamer, Jeroen B., Verbakel, Wilko F.A.R., Keskin-Cambay, Fatma, Reitsma, Johannes B., Van Der Schaaf, Arjen, Boersma, Liesbeth J., and Schuit, Ewoud

Abstract

In the Netherlands, the model-based approach is used to identify patients with head and neck cancer who may benefit most from proton therapy in terms of prevention of late radiation-induced side effects in comparison with photon therapy. To this purpose, a National Indication Protocol Proton therapy for Head and Neck Cancer patients (NIPPHNC) was developed, which has been approved by the health care authorities. When patients qualify according to the guidelines of the NIPP-HNC, proton therapy is fully reimbursed. This article describes the procedures that were followed to develop this NIPP-HNC and provides all necessary information to introduce model-based selection for patients with head and neck cancer into routine clinical practice.

Published
2021

26. Magnetic resonance guided elective neck irradiation targeting individual lymph nodes: A new concept

Author

Fysica Radiotherapie Research, MS Radiotherapie, Cancer, Klinische Fysica RT, Reinders, Floris C.J., Heijst, Tristan C.F.van, Mases, Joel, Terhaard, Chris H.J., Doornaert, Patricia A.H., Philippens, Marielle E.P., Raaijmakers, Cornelis P.J., Fysica Radiotherapie Research, MS Radiotherapie, Cancer, Klinische Fysica RT, Reinders, Floris C.J., Heijst, Tristan C.F.van, Mases, Joel, Terhaard, Chris H.J., Doornaert, Patricia A.H., Philippens, Marielle E.P., and Raaijmakers, Cornelis P.J.

Published
2021

27. National Protocol for Model-Based Selection for Proton Therapy in Head and Neck Cancer

Author

MS Radiotherapie, Cancer, Epi Methoden Team 4, Circulatory Health, JC onderzoeksprogramma Methodologie, Epi Methoden Team 1, Langendijk, Johannes A, Hoebers, Frank J P, de Jong, Martin A, Doornaert, Patricia, Terhaard, Chris H J, Steenbakkers, Roel J H M, Hamming-Vrieze, Olga, van de Kamer, Jeroen B, Verbakel, Wilko F A R, Keskin-Cambay, Fatma, Reitsma, Johannes B, van der Schaaf, Arjen, Boersma, Liesbeth J, Schuit, Ewoud, MS Radiotherapie, Cancer, Epi Methoden Team 4, Circulatory Health, JC onderzoeksprogramma Methodologie, Epi Methoden Team 1, Langendijk, Johannes A, Hoebers, Frank J P, de Jong, Martin A, Doornaert, Patricia, Terhaard, Chris H J, Steenbakkers, Roel J H M, Hamming-Vrieze, Olga, van de Kamer, Jeroen B, Verbakel, Wilko F A R, Keskin-Cambay, Fatma, Reitsma, Johannes B, van der Schaaf, Arjen, Boersma, Liesbeth J, and Schuit, Ewoud

Published
2021

28. Cost-utility and cost-effectiveness of a guided self-help head and neck exercise program for patients treated with total laryngectomy: Results of a multi-center randomized controlled trial

Author

Divisie Beeld & Oncologie, MS Hoofd-Hals Chirurgische Oncologie, Cancer, MS Radiotherapie, Jansen, Femke, Coupé, Veerle M.H., Eerenstein, Simone E.J., Cnossen, Ingrid C., van Uden-Kraan, Cornelia F., de Bree, Remco, Doornaert, Patricia, Halmos, György B., Hardillo, José A.U., van Hinte, Gerben, Honings, Jimmie, Leemans, C. René, Verdonck-de Leeuw, Irma M., Divisie Beeld & Oncologie, MS Hoofd-Hals Chirurgische Oncologie, Cancer, MS Radiotherapie, Jansen, Femke, Coupé, Veerle M.H., Eerenstein, Simone E.J., Cnossen, Ingrid C., van Uden-Kraan, Cornelia F., de Bree, Remco, Doornaert, Patricia, Halmos, György B., Hardillo, José A.U., van Hinte, Gerben, Honings, Jimmie, Leemans, C. René, and Verdonck-de Leeuw, Irma M.

Published
2021

29. F-18-FDG-PET/CT-based treatment planning for definitive (chemo) radiotherapy in patients with head and neck squamous cell carcinoma improves regional control and survival

Author

Bosch, S van den, Doornaert, Patricia A. H., Dijkema, T., Zwijnenburg, E.M., Verhoef, L.C.G., Hoeben, B.A.W., Terhaard, C.H.J., Kaanders, J.H.A.M., Bosch, S van den, Doornaert, Patricia A. H., Dijkema, T., Zwijnenburg, E.M., Verhoef, L.C.G., Hoeben, B.A.W., Terhaard, C.H.J., and Kaanders, J.H.A.M.

Abstract

Contains fulltext : 216649.pdf (Publisher’s version ) (Open Access)

Published
2020

30. Uniform FDG‐PET guided gradient dose prescription in head and neck cancer: prologue to the UPGRADE‐RT trial

Author

Kaanders, J.H.A.M., Oyen, W.J.G., Dijkema, T., Doornaert, Patricia A. H., Bosch, S van den, Kaanders, J.H.A.M., Oyen, W.J.G., Dijkema, T., Doornaert, Patricia A. H., and Bosch, S van den

Abstract

Radboud University, 06 oktober 2020, Promotores : Kaanders, J.H.A.M., Oyen, W.J.G. Co-promotores : Dijkema, T., Doornaert, Patricia A. H., Contains fulltext : 222083.pdf (publisher's version ) (Open Access)

Published
2020

31. Effectiveness of a guided self-help exercise program tailored to patients treated with total laryngectomy : Results of a multi-center randomized controlled trial

Author

Jansen, Femke, Eerenstein, Simone E.J., Cnossen, Ingrid C., Lissenberg-Witte, Birgit I., de Bree, Remco, Doornaert, Patricia, Halmos, György B., Hardillo, José A.U., van Hinte, Gerben, Honings, Jimmie, van Uden-Kraan, Cornelia F., Leemans, C. René, Verdonck-de Leeuw, Irma M., Jansen, Femke, Eerenstein, Simone E.J., Cnossen, Ingrid C., Lissenberg-Witte, Birgit I., de Bree, Remco, Doornaert, Patricia, Halmos, György B., Hardillo, José A.U., van Hinte, Gerben, Honings, Jimmie, van Uden-Kraan, Cornelia F., Leemans, C. René, and Verdonck-de Leeuw, Irma M.

Published
2020

32. 18F-FDG-PET/CT-based treatment planning for definitive (chemo)radiotherapy in patients with head and neck squamous cell carcinoma improves regional control and survival

Author

van den Bosch, Sven, Doornaert, Patricia A H, Dijkema, Tim, Zwijnenburg, Ellen M, Verhoef, Lia C G, Hoeben, Bianca A W, Kasperts, Nicolien, Smid, Ernst J, Terhaard, Chris H J, Kaanders, Johannes H A M, van den Bosch, Sven, Doornaert, Patricia A H, Dijkema, Tim, Zwijnenburg, Ellen M, Verhoef, Lia C G, Hoeben, Bianca A W, Kasperts, Nicolien, Smid, Ernst J, Terhaard, Chris H J, and Kaanders, Johannes H A M

Published
2020

33. Effectiveness of a guided self-help exercise program tailored to patients treated with total laryngectomy: Results of a multi-center randomized controlled trial

Author

MS Hoofd-Hals Chirurgische Oncologie, Cancer, MS Radiotherapie, Jansen, Femke, Eerenstein, Simone E.J., Cnossen, Ingrid C., Lissenberg-Witte, Birgit I., de Bree, Remco, Doornaert, Patricia, Halmos, György B., Hardillo, José A.U., van Hinte, Gerben, Honings, Jimmie, van Uden-Kraan, Cornelia F., Leemans, C. René, Verdonck-de Leeuw, Irma M., MS Hoofd-Hals Chirurgische Oncologie, Cancer, MS Radiotherapie, Jansen, Femke, Eerenstein, Simone E.J., Cnossen, Ingrid C., Lissenberg-Witte, Birgit I., de Bree, Remco, Doornaert, Patricia, Halmos, György B., Hardillo, José A.U., van Hinte, Gerben, Honings, Jimmie, van Uden-Kraan, Cornelia F., Leemans, C. René, and Verdonck-de Leeuw, Irma M.

Published
2020

34. 18F-FDG-PET/CT-based treatment planning for definitive (chemo)radiotherapy in patients with head and neck squamous cell carcinoma improves regional control and survival

Author

MS Radiotherapie, Cancer, van den Bosch, Sven, Doornaert, Patricia A H, Dijkema, Tim, Zwijnenburg, Ellen M, Verhoef, Lia C G, Hoeben, Bianca A W, Kasperts, Nicolien, Smid, Ernst J, Terhaard, Chris H J, Kaanders, Johannes H A M, MS Radiotherapie, Cancer, van den Bosch, Sven, Doornaert, Patricia A H, Dijkema, Tim, Zwijnenburg, Ellen M, Verhoef, Lia C G, Hoeben, Bianca A W, Kasperts, Nicolien, Smid, Ernst J, Terhaard, Chris H J, and Kaanders, Johannes H A M

Published
2020

35. Targeted Intervention to Improve the Quality of Head and Neck Radiation Therapy Treatment Planning in the Netherlands: Short and Long-Term Impact

Author

Verbakel, W., Doornaert, Patricia A. H., Raaijmakers, C.P., Bos, Luc J., Essers, Marion, Kamer, Jeroen B. van de, Terhaard, C.H.J., Kaanders, J.H.A.M., Verbakel, W., Doornaert, Patricia A. H., Raaijmakers, C.P., Bos, Luc J., Essers, Marion, Kamer, Jeroen B. van de, Terhaard, C.H.J., and Kaanders, J.H.A.M.

Abstract

Item does not contain fulltext

Published
2019

36. Dosimetric evaluation of synthetic CT for head and neck radiotherapy generated by a patch-based three-dimensional convolutional neural network

Author

Dinkla, Anna M, Florkow, Mateusz C, Maspero, Matteo, Savenije, Mark H F, Zijlstra, Frank, Doornaert, Patricia A H, van Stralen, Marijn, Philippens, Marielle E P, van den Berg, Cornelis A T, Seevinck, Peter R, Dinkla, Anna M, Florkow, Mateusz C, Maspero, Matteo, Savenije, Mark H F, Zijlstra, Frank, Doornaert, Patricia A H, van Stralen, Marijn, Philippens, Marielle E P, van den Berg, Cornelis A T, and Seevinck, Peter R

Published
2019

37. Targeted Intervention to Improve the Quality of Head and Neck Radiation Therapy Treatment Planning in the Netherlands : Short and Long-Term Impact

Author

Verbakel, Wilko F A R, Doornaert, Patricia A H, Raaijmakers, Cornelis P J, Bos, Luc J, Essers, Marion, van de Kamer, Jeroen B, Dahele, Max, Terhaard, Chris H J, Kaanders, Johannes H A M, Verbakel, Wilko F A R, Doornaert, Patricia A H, Raaijmakers, Cornelis P J, Bos, Luc J, Essers, Marion, van de Kamer, Jeroen B, Dahele, Max, Terhaard, Chris H J, and Kaanders, Johannes H A M

Published
2019

38. Targeted Intervention to Improve the Quality of Head and Neck Radiation Therapy Treatment Planning in the Netherlands: Short and Long-Term Impact

Author

MS Radiotherapie, Cancer, Klinische Fysica RT, Verbakel, Wilko F A R, Doornaert, Patricia A H, Raaijmakers, Cornelis P J, Bos, Luc J, Essers, Marion, van de Kamer, Jeroen B, Dahele, Max, Terhaard, Chris H J, Kaanders, Johannes H A M, MS Radiotherapie, Cancer, Klinische Fysica RT, Verbakel, Wilko F A R, Doornaert, Patricia A H, Raaijmakers, Cornelis P J, Bos, Luc J, Essers, Marion, van de Kamer, Jeroen B, Dahele, Max, Terhaard, Chris H J, and Kaanders, Johannes H A M

Published
2019

39. Dosimetric evaluation of synthetic CT for head and neck radiotherapy generated by a patch-based three-dimensional convolutional neural network

Author

Computational Imaging, Beeldverwerking ISI, Radiotherapie, Cancer, MS Radiotherapie, Researchgr. Beeldg. Moleculaire Interv., Klinische Fysica RT, Regenerative Medicine and Stem Cells, Dinkla, Anna M, Florkow, Mateusz C, Maspero, Matteo, Savenije, Mark H F, Zijlstra, Frank, Doornaert, Patricia A H, van Stralen, Marijn, Philippens, Marielle E P, van den Berg, Cornelis A T, Seevinck, Peter R, Computational Imaging, Beeldverwerking ISI, Radiotherapie, Cancer, MS Radiotherapie, Researchgr. Beeldg. Moleculaire Interv., Klinische Fysica RT, Regenerative Medicine and Stem Cells, Dinkla, Anna M, Florkow, Mateusz C, Maspero, Matteo, Savenije, Mark H F, Zijlstra, Frank, Doornaert, Patricia A H, van Stralen, Marijn, Philippens, Marielle E P, van den Berg, Cornelis A T, and Seevinck, Peter R

Published
2019

40. Sparing the contralateral submandibular gland without compromising PTV coverage by using volumetric modulated arc therapy

Author

Slotman Ben J, Rietveld Derek HF, Verbakel Wilko FAR, Doornaert Patricia, and Senan Suresh

Subjects
submandibular gland sparing, volumetric modulated arc therapy, RapidArc, head and neck cancer, dose distribution, xerostomia, Medical physics. Medical radiology. Nuclear medicine, R895-920, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background Salivary gland function decreases after radiation doses of 39 Gy or higher. Currently, submandibular glands are not routinely spared. We implemented a technique for sparing contralateral submandibular glands (CLSM) during contralateral elective neck irradiation without compromising PTV coverage. Methods Volumetric modulated arc therapy (RapidArc™) plans were applied in 31 patients with stage II-IV HNC without contralateral neck metastases, all of whom received elective treatment to contralateral nodal levels II-IV. Group 1 consisted of 21 patients undergoing concurrent chemo-radiotherapy, with elective nodal doses of 57.75 Gy (PTVelect) and 70 Gy to tumor and pathological nodes (PTVboost) in 7 weeks. Group 2 consisted of 10 patients treated with radiotherapy to 54.45 Gy to PTVelect and 70 Gy to PTVboost in 6 weeks. All clinical plans spared the CLSM using individually adapted constraints. For each patient, a second plan was retrospectively generated without CLSM constraints ('non-sparing plan'). Results PTV coverage was similar for both plans, with 98.7% of PTVelect and 99.2% of PTVboost receiving ≥95% of the prescription dose. The mean CLSM dose in group 1 was 33.2 Gy for clinical plans, versus 50.6 Gy in 'non-sparing plans' (p < 0.001). In group 2, mean CLSM dose was 34.4 Gy for clinical plans, and 46.8 Gy for non-sparing plans (p = 0.002). Conclusions Elective radiotherapy to contralateral nodal levels II-IV using RapidArc consistently limited CLSM doses well below 39 Gy, without compromising PTV-coverage. Future studies will reveal if this extent of dose reduction can reduce patient symptoms.

Published
2011
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41. Uniform FDG-PET guided GRAdient Dose prEscription to reduce late Radiation Toxicity (UPGRADE-RT) : study protocol for a randomized clinical trial with dose reduction to the elective neck in head and neck squamous cell carcinoma

Author

van den Bosch, Sven, Dijkema, Tim, Kunze-Busch, Martina C, Terhaard, Chris H J, Raaijmakers, CPJ, Doornaert, Patricia A H, Hoebers, Frank J P, Vergeer, Marije R, Kreike, Bas, Wijers, Oda B, Oyen, Wim J G, Kaanders, Johannes H A M, van den Bosch, Sven, Dijkema, Tim, Kunze-Busch, Martina C, Terhaard, Chris H J, Raaijmakers, CPJ, Doornaert, Patricia A H, Hoebers, Frank J P, Vergeer, Marije R, Kreike, Bas, Wijers, Oda B, Oyen, Wim J G, and Kaanders, Johannes H A M

Published
2017

42. Prophylactic exercises among head and neck cancer patients during and after swallowing sparing intensity modulated radiation : adherence and exercise performance levels of a 12-week guided home-based program

Author

Cnossen, Ingrid C., van Uden-Kraan, Cornelia F., Witte, Birgit I., Aalders, Yke J., de Goede, Cees J T, de Bree, Remco, Doornaert, Patricia, Rietveld, Derek H F, Buter, Jan, Langendijk, Johannes A., Leemans, C. René, Verdonck-de Leeuw, Irma M., Cnossen, Ingrid C., van Uden-Kraan, Cornelia F., Witte, Birgit I., Aalders, Yke J., de Goede, Cees J T, de Bree, Remco, Doornaert, Patricia, Rietveld, Derek H F, Buter, Jan, Langendijk, Johannes A., Leemans, C. René, and Verdonck-de Leeuw, Irma M.

Published
2017

43. Prophylactic exercises among head and neck cancer patients during and after swallowing sparing intensity modulated radiation: adherence and exercise performance levels of a 12-week guided home-based program

Author

MS Hoofd-Hals Chirurgische Oncologie, Cancer, MS Radiotherapie, Cnossen, Ingrid C., van Uden-Kraan, Cornelia F., Witte, Birgit I., Aalders, Yke J., de Goede, Cees J T, de Bree, Remco, Doornaert, Patricia, Rietveld, Derek H F, Buter, Jan, Langendijk, Johannes A., Leemans, C. René, Verdonck-de Leeuw, Irma M., MS Hoofd-Hals Chirurgische Oncologie, Cancer, MS Radiotherapie, Cnossen, Ingrid C., van Uden-Kraan, Cornelia F., Witte, Birgit I., Aalders, Yke J., de Goede, Cees J T, de Bree, Remco, Doornaert, Patricia, Rietveld, Derek H F, Buter, Jan, Langendijk, Johannes A., Leemans, C. René, and Verdonck-de Leeuw, Irma M.

Published
2017

44. Uniform FDG-PET guided GRAdient Dose prEscription to reduce late Radiation Toxicity (UPGRADE-RT): study protocol for a randomized clinical trial with dose reduction to the elective neck in head and neck squamous cell carcinoma

Author

van den Bosch, Sven, primary, Dijkema, Tim, additional, Kunze-Busch, Martina C., additional, Terhaard, Chris H. J., additional, Raaijmakers, Cornelis P. J., additional, Doornaert, Patricia A. H., additional, Hoebers, Frank J. P., additional, Vergeer, Marije R., additional, Kreike, Bas, additional, Wijers, Oda B., additional, Oyen, Wim J. G., additional, and Kaanders, Johannes H. A. M., additional

Published
2017
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45. Quality-of-life after radiotherapy for advanced laryngeal cancer : Results of a phase III trial of the Dutch Head and Neck Society

Author

Janssens, Geert O., Langendijk, Johannes A., Terhaard, Chris H., Doornaert, Patricia A., Van Den Ende, Piet, De Jong, Martin A., Takes, Robert P., Span, Paul N., Kaanders, Johannes H., Janssens, Geert O., Langendijk, Johannes A., Terhaard, Chris H., Doornaert, Patricia A., Van Den Ende, Piet, De Jong, Martin A., Takes, Robert P., Span, Paul N., and Kaanders, Johannes H.

Published
2016

46. Effectiveness and cost-utility of a guided self-help exercise program for patients treated with total laryngectomy : Protocol of a multi-center randomized controlled trial

Author

Jansen, Femke, Cnossen, Ingrid C., Eerenstein, Simone E J, Coupé, Veerle M H, Witte, Birgit I., van Uden-Kraan, Cornelia F., Doornaert, Patricia, Braunius, Weibel W., De Bree, Remco, Hardillo, José A U, Honings, Jimmie, Halmos, György B., Leemans, C. René, Verdonck-de Leeuw, Irma M., Jansen, Femke, Cnossen, Ingrid C., Eerenstein, Simone E J, Coupé, Veerle M H, Witte, Birgit I., van Uden-Kraan, Cornelia F., Doornaert, Patricia, Braunius, Weibel W., De Bree, Remco, Hardillo, José A U, Honings, Jimmie, Halmos, György B., Leemans, C. René, and Verdonck-de Leeuw, Irma M.

Published
2016

47. Quality-of-life after radiotherapy for advanced laryngeal cancer: Results of a phase III trial of the Dutch Head and Neck Society

Author

MS Radiotherapie, Cancer, Janssens, Geert O., Langendijk, Johannes A., Terhaard, Chris H., Doornaert, Patricia A., Van Den Ende, Piet, De Jong, Martin A., Takes, Robert P., Span, Paul N., Kaanders, Johannes H., MS Radiotherapie, Cancer, Janssens, Geert O., Langendijk, Johannes A., Terhaard, Chris H., Doornaert, Patricia A., Van Den Ende, Piet, De Jong, Martin A., Takes, Robert P., Span, Paul N., and Kaanders, Johannes H.

Published
2016

48. Effectiveness and cost-utility of a guided self-help exercise program for patients treated with total laryngectomy: Protocol of a multi-center randomized controlled trial

Author

MS Radiotherapie, Divisie Beeld & Oncologie, MS KNO, Other research (not in main researchprogram), MS Hoofd-Hals Chirurgische Oncologie, Cancer, Jansen, Femke, Cnossen, Ingrid C., Eerenstein, Simone E J, Coupé, Veerle M H, Witte, Birgit I., van Uden-Kraan, Cornelia F., Doornaert, Patricia, Braunius, Weibel W., De Bree, Remco, Hardillo, José A U, Honings, Jimmie, Halmos, György B., Leemans, C. René, Verdonck-de Leeuw, Irma M., MS Radiotherapie, Divisie Beeld & Oncologie, MS KNO, Other research (not in main researchprogram), MS Hoofd-Hals Chirurgische Oncologie, Cancer, Jansen, Femke, Cnossen, Ingrid C., Eerenstein, Simone E J, Coupé, Veerle M H, Witte, Birgit I., van Uden-Kraan, Cornelia F., Doornaert, Patricia, Braunius, Weibel W., De Bree, Remco, Hardillo, José A U, Honings, Jimmie, Halmos, György B., Leemans, C. René, and Verdonck-de Leeuw, Irma M.

Published
2016

49. Diffusion-weighted EPI- and HASTE-MRI and 18F-FDG-PET-CT early during chemoradiotherapy in advanced head and neck cancer

Author

Schouten, Charlotte S., de Bree, Remco, van der Putten, Lisa, Noij, Daniel P., Hoekstra, Otto S., Comans, Emile F.I., Witte, Birgit I., Doornaert, Patricia A., Leemans, C. René, and Castelijns, Jonas A.

Subjects
Original Article
Abstract

Diffusion-weighted MRI (DW-MRI) has potential to predict chemoradiotherapy (CRT) response in head and neck squamous cell carcinoma (HNSCC) and is generally performed using echo-planar imaging (EPI). However, EPI-DWI is susceptible to geometric distortions. Half-fourier acquisition single-shot turbo spin-echo (HASTE)-DWI may be an alternative. This prospective pilot study evaluates the potential predictive value of EPI- and HASTE-DWI and 18F-fluorodeoxyglucose PET-CT (18F-FDG-PET-CT) early during CRT for locoregional outcome in HNSCC.Eight patients with advanced HNSCC (7 primary tumors and 25 nodal metastases) scheduled for CRT, underwent DW-MRI (using both EPI- and HASTE-DWI) and 18F-FDG-PET(-CT) pretreatment, early during treatment and three months after treatment. Median follow-up time was 38 months.No local recurrences were detected during follow-up. Median Apparent Diffusion Coefficient (ADC)EPI-values in primary tumors increased from 77×10(-5) mm(2)/s pretreatment, to 113×10(-5) mm(2)/s during treatment (P=0.02), whereas ADCHASTE did not increase (74 and 74 mm(2)/s, respectively). Two regional recurrences were diagnosed. During treatment, ADCEPI tended to be higher for patients with regional control [(117.3±12.1)×10(-5) mm(2)/s] than for patients with a recurrence [(98.0±4.2)×10(-5) mm(2)/s]. This difference was not seen with ADCHASTE. No correlations between ΔADCEPI and ΔSUV (Standardized Uptake Value) were found in the primary tumor or nodal metastases.HASTE-DWI seems to be inadequate in early CRT response prediction, compared to EPI-DWI which has potential to predict locoregional outcome. EPI-DWI and 18F-FDG-PET-CT potentially provide independent information in the early response to treatment, since no correlations were found between ΔADCEPI and ΔSUV.

Published
2014

50. Effectiveness and cost-utility of a guided self-help exercise program for patients treated with total laryngectomy: protocol of a multi-center randomized controlled trial

Author

Jansen, Femke, primary, Cnossen, Ingrid C., additional, Eerenstein, Simone E. J., additional, Coupé, Veerle M. H., additional, Witte, Birgit I., additional, van Uden-Kraan, Cornelia F., additional, Doornaert, Patricia, additional, Braunius, Weibel W., additional, De Bree, Remco, additional, Hardillo, José A. U., additional, Honings, Jimmie, additional, Halmos, György B., additional, Leemans, C. René, additional, and Verdonck-de Leeuw, Irma M., additional

Published
2016
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