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1. AD−1 Small Molecule Improves Learning and Memory Function in Scopolamine-Induced Amnesic Mice Model through Regulation of CREB/BDNF and NF-κB/MAPK Signaling Pathway

Author

Rengasamy Balakrishnan, Ju-Young Park, Duk-Yeon Cho, Jae-Yong Ahn, Dong-Sun Yoo, Sang-Ho Seol, Sung-Hwa Yoon, and Dong-Kug Choi

Subjects
AD−1 small molecule, scopolamine, oxidative stress, memory impairment, neuroinflammation, apoptosis, Therapeutics. Pharmacology, RM1-950
Abstract

Cognitive decline and memory impairment induced by oxidative brain damage are the critical pathological hallmarks of Alzheimer’s disease (AD). Based on the potential neuroprotective effects of AD−1 small molecule, we here explored the possible underlying mechanisms of the protective effect of AD-1 small molecule against scopolamine-induced oxidative stress, neuroinflammation, and neuronal apoptosis. According to our findings, scopolamine administration resulted in increased AChE activity, MDA levels, and decreased antioxidant enzymes, as well as the downregulation of the antioxidant response proteins of Nrf2 and HO-1 expression; however, treatment with AD−1 small molecule mitigated the generation of oxidant factors while restoring the antioxidant enzymes status, in addition to improving antioxidant protein levels. Similarly, AD−1 small molecule significantly increased the protein expression of neuroprotective markers such as BDNF and CREB and promoted memory processes in scopolamine-induced mice. Western blot analysis showed that AD−1 small molecule reduced activated microglia and astrocytes via the attenuation of iba-1 and GFAP protein expression. We also found that scopolamine enhanced the phosphorylation of NF-κB/MAPK signaling and, conversely, that AD−1 small molecule significantly inhibited the phosphorylation of NF-κB/MAPK signaling in the brain regions of hippocampus and cortex. We further found that scopolamine promoted neuronal loss by inducing Bax and caspase-3 and reducing the levels of the antiapoptotic protein Bcl-2. In contrast, AD−1 small molecule significantly decreased the levels of apoptotic markers and increased neuronal survival. Furthermore, AD−1 small molecule ameliorated scopolamine-induced impairments in spatial learning behavior and memory formation. These findings revealed that AD−1 small molecule attenuated scopolamine-induced cognitive and memory dysfunction by ameliorating AChE activity, oxidative brain damage, neuroinflammation, and neuronal apoptosis.

Published
2023
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2. Simulation of Hydrological and Sediment Behaviors in the Doam-dam Watershed considering Soil Properties of the Soil Reconditioned Agricultural Fields

Author

Ki-Sung Kim, Jong-Suk Yoon, Dong-Sun Yoo, Jae-Hun Ahn, Sung-Gu Heo, Jae-Young Kim, and Kyoung Jae Lim

Subjects
Hydrology, Soil map, Topsoil, Watershed, Pedotransfer function, Soil and Water Assessment Tool, Environmental science, Sediment, Soil science, SWAT model, Leaching model
Abstract

The alpine agricultural activities are usually performed at higher and steep areas in nature. Thus, significant amounts of soil erosion are occurring compared with those from other areas. Thus, the soil erosion induced environmental impacts in these areas are getting greater. The Doam watershed is located at alpine areas and it has been well known that the agricultural activities in the watershed are causing accelerated soil erosion and water quality degradations. Many modeling approaches were employed to solve soil erosion and water quality issues. In this study, the Soil and Water Assessment Tool (SWAT) model was utilized to simulate the hydrologic and sediment behaviors in the Doam watershed. In many previous modeling studies, the digital soil map and its corresponding soil properties were used without modification to reflect soil conditioning at many agricultural fields of the Doam watershed. Thus, the soil sample was taken at the agricultural field within the Doam watershed and analyzed for its physical properties. In this study, the digital topsoil properties in the agricultural fields within the Doam watershed were replaced with the soil properties for reconditioned soil analyzed in this study to simulate the impacts of using soil properties for reconditioned soil in hydrologic and sediment modeling at the Doam watershed using the SWAT model. The hydrologic component of the SWAT model was calibrated and validated for measured flow data from 2002 to 2003. The value was 0.79 and the EI value was 0.53 for weekly simulated data. The calibrated model parameters were used for hydrologic component validation and the value was 0.86 and the EI value was 0.74 for weekly data. For sediment comparison, the value was 0.67 and the EI value was 0.59. These statistics improved with the use of soil properties of the reconditioned soil in the field compared with the results obtained without considering soil reconditioning. The simulated sediment amounts with and without considering the soil properties of the reconditioned soil were 284,813 ton and 158,369 ton, respectively. This result indicates that there could be approximately 79% of errors in estimated sediment yield at the Doam watershed, although the model comparison with the measured data gave similar satisfactory statistics with and without considering soil properties from the reconditioned soil.

Published
2007

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