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1. Time-restricted feeding attenuates hypercholesterolaemia and atherosclerosis development during circadian disturbance in APOE∗3-Leiden.CETP mice

Author

In Het Panhuis, Wietse, Schönke, Milena, Modder, Melanie, Tom, Hannah E., Lalai, Reshma A., Pronk, Amanda C.M., Streefland, Trea C.M., van Kerkhof, Linda W.M., Dollé, Martijn E.T., Depuydt, Marie A.C., Bot, Ilze, Vos, Winnie G., Bosmans, Laura A., van Os, Bram W., Lutgens, Esther, Rensen, Patrick C.N., and Kooijman, Sander

Published
2023
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3. Gender- and age-dependencies of oxidative stress, as detected based on the steady state concentrations of different biomarkers in the MARK-AGE study

Author

Pinchuk, Ilya, Weber, Daniela, Kochlik, Bastian, Stuetz, Wolfgang, Toussaint, Olivier, Debacq-Chainiaux, Florence, Dollé, Martijn E.T., Jansen, Eugène H.J.M., Gonos, Efstathios S., Sikora, Ewa, Breusing, Nicolle, Gradinaru, Daniela, Sindlinger, Thilo, Moreno-Villanueva, María, Bürkle, Alexander, Grune, Tilman, and Lichtenberg, Dov

Published
2019
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4. Association of torquetenovirus viremia with physical frailty and cognitive impairment in three independent european cohorts

Author

Giacconi, Robertina, Laffon, Blanca, Costa, Solange, Teixeira-Gomes, Armanda, Maggi, Fabrizio, Macera, Lisa, Spezia, Pietro Giogio, Piacenza, Francesco, Bürkle, Alexander, Moreno-Villanueva, María, Bonassi, Stefano, Valdiglesias, Vanessa, Teixeira, Joao Paulo, Dollé, Martijn E.T., Rietman, M. Liset, Jansen, Eugène, Grune, Tilman, Gonos, Efstathios S., Franchesci, Claudio, Capri, Miriam, Weinberger, Birgit, Sikora, Ewa, Stuetz, Wolfgang, Toussaint, Olivier, Debacq-Chainiaux, Florence, Hervonen, Antti, Hurme, Mikko, Slagboom, P. Eline, Schön, Christiane, Bernhardt, Jürgen, Breusing, Nicolle, Pásaro, Eduardo, Maseda, Ana, Lorenzo-López, Laura, Millán-Calenti, José Carlos, Provinciali, Mauro, Malavolta, Marco, Giacconi, Robertina, Laffon, Blanca, Costa, Solange, Teixeira-Gomes, Armanda, Maggi, Fabrizio, Macera, Lisa, Spezia, Pietro Giogio, Piacenza, Francesco, Bürkle, Alexander, Moreno-Villanueva, María, Bonassi, Stefano, Valdiglesias, Vanessa, Teixeira, Joao Paulo, Dollé, Martijn E.T., Rietman, M. Liset, Jansen, Eugène, Grune, Tilman, Gonos, Efstathios S., Franchesci, Claudio, Capri, Miriam, Weinberger, Birgit, Sikora, Ewa, Stuetz, Wolfgang, Toussaint, Olivier, Debacq-Chainiaux, Florence, Hervonen, Antti, Hurme, Mikko, Slagboom, P. Eline, Schön, Christiane, Bernhardt, Jürgen, Breusing, Nicolle, Pásaro, Eduardo, Maseda, Ana, Lorenzo-López, Laura, Millán-Calenti, José Carlos, Provinciali, Mauro, and Malavolta, Marco

Abstract

[Abstract] Introduction: Immunosenescence and inflammaging have been implicated in the pathophysiology of frailty. Torquetenovirus (TTV), a single-stranded DNA anellovirus, the major component of the human blood virome, shows an increased replication rate with advancing age. An elevated TTV viremia has been associated with an impaired immune function and an increased risk of mortality in the older population. The objective of this study was to analyze the relation between TTV viremia, physical frailty, and cognitive impairment. Methods: TTV viremia was measured in 1,131 nonfrail, 45 physically frail, and 113 cognitively impaired older adults recruited in the MARK-AGE study (overall mean age 64.7 ± 5.9 years), and then the results were checked in two other independent cohorts from Spain and Portugal, including 126 frail, 252 prefrail, and 141 nonfrail individuals (overall mean age: 77.5 ± 8.3 years). Results: TTV viremia ≥4log was associated with physical frailty (OR: 4.69; 95% CI: 2.06-10.67, p < 0.0001) and cognitive impairment (OR: 3.49, 95% CI: 2.14-5.69, p < 0.0001) in the MARK-AGE population. The association between TTV DNA load and frailty status was confirmed in the Spanish cohort, while a slight association with cognitive impairment was observed (OR: 1.33; 95% CI: 1.000-1.773), only in the unadjusted model. No association between TTV load and frailty or cognitive impairment was found in the Portuguese sample, although a negative association between TTV viremia and MMSE score was observed in Spanish and Portuguese females. Conclusions: These findings demonstrate an association between TTV viremia and physical frailty, while the association with cognitive impairment was observed only in the younger population from the MARK-AGE study. Further research is necessary to clarify TTV's clinical relevance in the onset and progression of frailty and cognitive decline in older individuals.

Published
2023

5. DNA methylation trajectories and accelerated epigenetic aging in incident type 2 diabetes

Author

Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Cardiometabolic Health, Fraszczyk, Eliza, Thio, Chris H.L., Wackers, Paul, Dollé, Martijn E.T., Bloks, Vincent W., Hodemaekers, Hennie, Picavet, H. Susan, Stynenbosch, Marjolein, Verschuren, W. M.Monique, Snieder, Harold, Spijkerman, Annemieke M.W., Luijten, Mirjam, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Cardiometabolic Health, Fraszczyk, Eliza, Thio, Chris H.L., Wackers, Paul, Dollé, Martijn E.T., Bloks, Vincent W., Hodemaekers, Hennie, Picavet, H. Susan, Stynenbosch, Marjolein, Verschuren, W. M.Monique, Snieder, Harold, Spijkerman, Annemieke M.W., and Luijten, Mirjam

Published
2022

6. Epigenome-wide association study of incident type 2 diabetes: a meta-analysis of five prospective European cohorts

Author

Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Cardiometabolic Health, Public Health Practice, Fraszczyk, Eliza, Spijkerman, Annemieke M.W., Zhang, Yan, Brandmaier, Stefan, Day, Felix R., Zhou, Li, Wackers, Paul, Dollé, Martijn E.T., Bloks, Vincent W., Gào, Xīn, Gieger, Christian, Kooner, Jaspal, Kriebel, Jennifer, Picavet, H. Susan J., Rathmann, Wolfgang, Schöttker, Ben, Loh, Marie, Verschuren, W. M.Monique, van Vliet-Ostaptchouk, Jana V., Wareham, Nicholas J., Chambers, John C., Ong, Ken K., Grallert, Harald, Brenner, Hermann, Luijten, Mirjam, Snieder, Harold, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Cardiometabolic Health, Public Health Practice, Fraszczyk, Eliza, Spijkerman, Annemieke M.W., Zhang, Yan, Brandmaier, Stefan, Day, Felix R., Zhou, Li, Wackers, Paul, Dollé, Martijn E.T., Bloks, Vincent W., Gào, Xīn, Gieger, Christian, Kooner, Jaspal, Kriebel, Jennifer, Picavet, H. Susan J., Rathmann, Wolfgang, Schöttker, Ben, Loh, Marie, Verschuren, W. M.Monique, van Vliet-Ostaptchouk, Jana V., Wareham, Nicholas J., Chambers, John C., Ong, Ken K., Grallert, Harald, Brenner, Hermann, Luijten, Mirjam, and Snieder, Harold

Published
2022

7. Blood cell DNA methylation biomarkers in preclinical malignant pleural mesothelioma : the EPIC prospective cohort

Author

Allione, Alessandra, Viberti, Clara, Cotellessa, Ilaria, Catalano, Chiara, Casalone, Elisabetta, Cugliari, Giovanni, Russo, Alessia, Guarrera, Simonetta, Mirabelli, Dario, Sacerdote, Carlotta, Gentile, Marco, Eichelmann, Fabian, Schulze, Matthias B., Harlid, Sophia, Eriksen, Anne Kirstine, Tjønneland, Anne, Andersson, Martin, Dollé, Martijn E.T., Van Puyvelde, Heleen, Weiderpass, Elisabete, Rodriguez-Barranco, Miguel, Agudo, Antonio, Heath, Alicia K., Chirlaque, María-Dolores, Truong, Thérèse, Dragic, Dzevka, Severi, Gianluca, Sieri, Sabina, Sandanger, Torkjel M., Ardanaz, Eva, Vineis, Paolo, Matullo, Giuseppe, Allione, Alessandra, Viberti, Clara, Cotellessa, Ilaria, Catalano, Chiara, Casalone, Elisabetta, Cugliari, Giovanni, Russo, Alessia, Guarrera, Simonetta, Mirabelli, Dario, Sacerdote, Carlotta, Gentile, Marco, Eichelmann, Fabian, Schulze, Matthias B., Harlid, Sophia, Eriksen, Anne Kirstine, Tjønneland, Anne, Andersson, Martin, Dollé, Martijn E.T., Van Puyvelde, Heleen, Weiderpass, Elisabete, Rodriguez-Barranco, Miguel, Agudo, Antonio, Heath, Alicia K., Chirlaque, María-Dolores, Truong, Thérèse, Dragic, Dzevka, Severi, Gianluca, Sieri, Sabina, Sandanger, Torkjel M., Ardanaz, Eva, Vineis, Paolo, and Matullo, Giuseppe

Abstract

Malignant pleural mesothelioma (MPM) is a rare and aggressive cancer mainly caused by asbestos exposure. Specific and sensitive noninvasive biomarkers may facilitate and enhance screening programs for the early detection of cancer. We investigated DNA methylation (DNAm) profiles in MPM prediagnostic blood samples in a case-control study nested in the European Prospective Investigation into Cancer and nutrition (EPIC) cohort, aiming to characterise DNAm biomarkers associated with MPM. From the EPIC cohort, we included samples from 135 participants who developed MPM during 20 years of follow-up and from 135 matched, cancer-free, controls. For the discovery phase we selected EPIC participants who developed MPM within 5 years from enrolment (n = 36) with matched controls. We identified nine differentially methylated CpGs, selected by 10-fold cross-validation and correlation analyses: cg25755428 (MRI1), cg20389709 (KLF11), cg23870316, cg13862711 (LHX6), cg06417478 (HOOK2), cg00667948, cg01879420 (AMD1), cg25317025 (RPL17) and cg06205333 (RAP1A). Receiver operating characteristic (ROC) analysis showed that the model including baseline characteristics (age, sex and PC1wbc) along with the nine MPM-related CpGs has a better predictive value for MPM occurrence than the baseline model alone, maintaining some performance also at more than 5 years before diagnosis (area under the curve [AUC] < 5 years = 0.89; AUC 5-10 years = 0.80; AUC >10 years = 0.75; baseline AUC range = 0.63-0.67). DNAm changes as noninvasive biomarkers in prediagnostic blood samples of MPM cases were investigated for the first time. Their application can improve the identification of asbestos-exposed individuals at higher MPM risk to possibly adopt more intensive monitoring for early disease identification.

Published
2022
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8. A randomized crossover trial assessing time of day snack consumption and resulting postprandial glycemic response in a real-life setting among healthy adults

Author

Timmer, Ruth, Bogaardt, Laurens, Brummelhuis, Walter J., van Oostrom, Conny T., van Kerkhof, Linda W.M., Wong, Albert, de Valk, Harold W., Ocké, Marga C., van der Maaden, Tessa, Dollé, Martijn E.T., Timmer, Ruth, Bogaardt, Laurens, Brummelhuis, Walter J., van Oostrom, Conny T., van Kerkhof, Linda W.M., Wong, Albert, de Valk, Harold W., Ocké, Marga C., van der Maaden, Tessa, and Dollé, Martijn E.T.

Abstract

The postprandial glycemic response is an important metabolic health factor, which, from laboratory studies, is known to change from low to high over the course of the day, and from which negative health outcomes have been linked to nightly eating. We applied interstitial continuous glucose monitoring to examine the glycemic response to a standardized carbohydrate-rich snack (198 kcal) across the day in a real-life setting. Twenty-four healthy participants (12 men, 12 women, 27–61 y old) consumed the snack nine times during 6 d in a crossover design, altering the time of consumption between morning, afternoon and evening. The snack was consumed in the participant’s own environment with a preceding fast of at least 2.5 h between their customary main meals and practices. Linear mixed models were used with fixed effect of timing, and participant as random effect, to assess incremental area under the curve, peak value and time-to-peak of the glycemic response. Overall, the highest glycemic excursions were observed in the morning, while a more dampened but prolonged response was observed in the evening. These findings do not concur with previously published laboratory studies. This implies that results obtained under controlled experimental conditions in laboratories cannot be generalized directly to predict chrononutritional effects on the glycemic response in healthy individuals and their daily routines.

Published
2022

9. Night shift work characteristics are associated with several elevated metabolic risk factors and immune cell counts in a cross-sectional study

Author

Streng, Astrid A., Loef, Bette, Dollé, Martijn E.T., van der Horst, Gijsbertus T.J., Chaves, Inês, Proper, Karin I., van Kerkhof, Linda W.M., Streng, Astrid A., Loef, Bette, Dollé, Martijn E.T., van der Horst, Gijsbertus T.J., Chaves, Inês, Proper, Karin I., and van Kerkhof, Linda W.M.

Abstract

Night shift work is associated with increased health risks. Here we examined the association of metabolic risk factors and immune cell counts, with both night shift work and particular characteristics thereof: frequency, duration and consecutive night shifts. We performed a cross-sectional study using data from 10,201 non-shift workers and 1062 night shift workers of the Lifelines Cohort study. Linear regression analyses, adjusted for demographic, lifestyle and occupational factors, were used to study associations of night shift work characteristics with metabolic risk factors and immune cell counts. Night shift workers had an increased BMI, waist circumference and immune cell counts compared to non-shift workers. This was especially seen in night shift workers who had a higher frequency of night shifts per month (≥ 5: BMI: B = 0.81 kg/m2 (95%-CI = 0.43–1.10); waist circumference: B = 1.58 cm (95%-Cl = 0.34–1.71; leukocytes: B = 0.19 × 109 cells/L (95%-CI = 0.04–0.34 × 109)) and worked more consecutive night shifts (> 3: BMI: B = 0.92 kg/m2 (95%-CI = 0.41–1.43); waist circumference: B = 1.85 cm (95%-Cl = 0.45–3.24); leukocytes: B = 0.32 × 109 cells/L (95%-CI = 0.09–0.55 × 109)). This association was less pronounced in long-term night shift workers (≥ 20 years). Our findings provide evidence for the association between night shift work characteristics and BMI, waist circumference and leukocytes (including, monocytes, lymphocytes, and basophil granulocytes).

Published
2022

10. A randomized crossover trial assessing time of day snack consumption and resulting postprandial glycemic response in a real-life setting among healthy adults

Author

MS Interne Geneeskunde, Circulatory Health, Timmer, Ruth, Bogaardt, Laurens, Brummelhuis, Walter J., van Oostrom, Conny T., van Kerkhof, Linda W.M., Wong, Albert, de Valk, Harold W., Ocké, Marga C., van der Maaden, Tessa, Dollé, Martijn E.T., MS Interne Geneeskunde, Circulatory Health, Timmer, Ruth, Bogaardt, Laurens, Brummelhuis, Walter J., van Oostrom, Conny T., van Kerkhof, Linda W.M., Wong, Albert, de Valk, Harold W., Ocké, Marga C., van der Maaden, Tessa, and Dollé, Martijn E.T.

Published
2022

15. Genome-wide Association Study of the Postprandial Triglyceride Response Yields Common Genetic Variation in Hepatic Lipase (LIPC)

Author

Ibi, Dorina, primary, Noordam, Raymond, additional, van Klinken, Jan Bert, additional, Li-Gao, Ruifang, additional, de Mutsert, Renée, additional, Trompet, Stella, additional, Christen, Tim, additional, Blauw, Lisanne L., additional, van Heemst, Diana, additional, Mook-Kanamori, Dennis O., additional, Rosendaal, Frits R., additional, Jukema, J. Wouter, additional, Dollé, Martijn E.T., additional, Rensen, Patrick C.N., additional, and Willems van Dijk, Ko, additional

Published
2020
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16. Identification of TUB as a Novel Candidate Gene Influencing Body Weight in Humans

Author

Shiri-Sverdlov, Ronit, Custers, Anne, van Vliet-Ostaptchouk, Jana V., van Gorp, Patrick J.J., Lindsey, Patrick J., van Tilburg, Jonathan H.O., Zhernakova, Sasha, Feskens, Edith J.M., van der A, Daphne L., Dollé, Martijn E.T., van Haeften, Timon W., Koeleman, Bobby P.C., Hofker, Marten H., and Wijmenga, Cisca

Published
2006

17. Disruption of circadian rhythm by alternating light-dark cycles aggravates atherosclerosis development in APOE*3-Leiden.CETP mice

Author

Schilperoort, Maaike, van den Berg, Rosa, Bosmans, Laura A., van Os, Bram W., Dollé, Martijn E.T., Smits, Noortje A.M., Guichelaar, Teun, van Baarle, Debbie, Koemans, Lotte, Berbée, Jimmy F.P., Deboer, Tom, Meijer, Johanna H., de Vries, Margreet R., Vreeken, Dianne, van Gils, Janine M., Willems van Dijk, Ko, van Kerkhof, Linda W.M., Lutgens, Esther, Biermasz, Nienke R., Rensen, Patrick C.N., Kooijman, Sander, Schilperoort, Maaike, van den Berg, Rosa, Bosmans, Laura A., van Os, Bram W., Dollé, Martijn E.T., Smits, Noortje A.M., Guichelaar, Teun, van Baarle, Debbie, Koemans, Lotte, Berbée, Jimmy F.P., Deboer, Tom, Meijer, Johanna H., de Vries, Margreet R., Vreeken, Dianne, van Gils, Janine M., Willems van Dijk, Ko, van Kerkhof, Linda W.M., Lutgens, Esther, Biermasz, Nienke R., Rensen, Patrick C.N., and Kooijman, Sander

Published
2020

18. Disruption of circadian rhythm by alternating light-dark cycles aggravates atherosclerosis development in APOE*3-Leiden.CETP mice

Author

CTI Research, Infection & Immunity, Schilperoort, Maaike, van den Berg, Rosa, Bosmans, Laura A., van Os, Bram W., Dollé, Martijn E.T., Smits, Noortje A.M., Guichelaar, Teun, van Baarle, Debbie, Koemans, Lotte, Berbée, Jimmy F.P., Deboer, Tom, Meijer, Johanna H., de Vries, Margreet R., Vreeken, Dianne, van Gils, Janine M., Willems van Dijk, Ko, van Kerkhof, Linda W.M., Lutgens, Esther, Biermasz, Nienke R., Rensen, Patrick C.N., Kooijman, Sander, CTI Research, Infection & Immunity, Schilperoort, Maaike, van den Berg, Rosa, Bosmans, Laura A., van Os, Bram W., Dollé, Martijn E.T., Smits, Noortje A.M., Guichelaar, Teun, van Baarle, Debbie, Koemans, Lotte, Berbée, Jimmy F.P., Deboer, Tom, Meijer, Johanna H., de Vries, Margreet R., Vreeken, Dianne, van Gils, Janine M., Willems van Dijk, Ko, van Kerkhof, Linda W.M., Lutgens, Esther, Biermasz, Nienke R., Rensen, Patrick C.N., and Kooijman, Sander

Published
2020

19. Protein and calorie restriction may improve outcomes in living kidney donors and kidney transplant recipients

Author

Jongbloed, Franny, de Bruin, Ron W.F., Van Steeg, Harry, Beekhof, Piet, Wackers, Paul, Hesselink, Dennis A., Hoeijmakers, Jan H.J., Dollé, Martijn E.T., Ijzermans, Jan N.M., Jongbloed, Franny, de Bruin, Ron W.F., Van Steeg, Harry, Beekhof, Piet, Wackers, Paul, Hesselink, Dennis A., Hoeijmakers, Jan H.J., Dollé, Martijn E.T., and Ijzermans, Jan N.M.

Abstract

Previously, we and others showed that dietary restriction protects against renal ischemia-reperfusion injury in animals. However, clinical translation of preoperative diets is scarce, and in the setting of kidney transplantation these data are lacking. In this pilot study, we investigated the effects of five days of a preoperative protein and caloric dietary restriction (PCR) diet in living kidney donors on the perioperative effects in donors, recipients and transplanted kidneys. Thirty-five kidney donors were randomized into either the PCR, 30% calorie and 80% protein reduction, or control group without restrictions. Adherence to the diet and kidney function in donors and their kidney recipients were analyzed. Perioperative kidney biopsies were taken in a selected group of transplanted kidneys for gene expression analysis. All donors adhered to the diet. From postoperative day 2 up until month 1, kidney function of donors was significantly better in the PCR-group. PCR-donor kidney recipients showed significantly improved kidney function and lower incidence of slow graft function and acute rejection. PCR inhibited cellular immune response pathways and activated stress-resistance signaling. These observations are the first to show that preoperative dietary restriction induces postoperative recovery benefits in humans and may be beneficial in clinical settings involving ischemia-reperfusion injury.

Published
2020

21. Antioxidants linked with physical, cognitive and psychological frailty : Analysis of candidate biomarkers and markers derived from the MARK-AGE study

Author

Rietman, M. Liset, Spijkerman, Annemieke M.W., Wong, Albert, van Steeg, Harry, Bürkle, Alexander, Moreno-Villanueva, María, Sindlinger, Thilo, Franceschi, Claudio, Grubeck-Loebenstein, Beatrix, Bernhardt, Jürgen, Slagboom, P. Eline, Toussaint, Olivier, Debacq-Chainiaux, Florence, Sikora, Ewa, Gonos, Efstathios S., Breusing, Nicolle, Stuetz, Wolfgang, Weber, Daniela, Grune, Tilman, Basso, Andrea, Piacenza, Francesco, Malavolta, Marco, Collino, Sebastiano, Jansen, Eugene H.J.M., Verschuren, W. M.Monique, Dollé, Martijn E.T., Rietman, M. Liset, Spijkerman, Annemieke M.W., Wong, Albert, van Steeg, Harry, Bürkle, Alexander, Moreno-Villanueva, María, Sindlinger, Thilo, Franceschi, Claudio, Grubeck-Loebenstein, Beatrix, Bernhardt, Jürgen, Slagboom, P. Eline, Toussaint, Olivier, Debacq-Chainiaux, Florence, Sikora, Ewa, Gonos, Efstathios S., Breusing, Nicolle, Stuetz, Wolfgang, Weber, Daniela, Grune, Tilman, Basso, Andrea, Piacenza, Francesco, Malavolta, Marco, Collino, Sebastiano, Jansen, Eugene H.J.M., Verschuren, W. M.Monique, and Dollé, Martijn E.T.

Published
2019

22. Antioxidants linked with physical, cognitive and psychological frailty: Analysis of candidate biomarkers and markers derived from the MARK-AGE study

Author

Public Health Epidemiologie, Other research (not in main researchprogram), Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Rietman, M. Liset, Spijkerman, Annemieke M.W., Wong, Albert, van Steeg, Harry, Bürkle, Alexander, Moreno-Villanueva, María, Sindlinger, Thilo, Franceschi, Claudio, Grubeck-Loebenstein, Beatrix, Bernhardt, Jürgen, Slagboom, P. Eline, Toussaint, Olivier, Debacq-Chainiaux, Florence, Sikora, Ewa, Gonos, Efstathios S., Breusing, Nicolle, Stuetz, Wolfgang, Weber, Daniela, Grune, Tilman, Basso, Andrea, Piacenza, Francesco, Malavolta, Marco, Collino, Sebastiano, Jansen, Eugene H.J.M., Verschuren, W. M.Monique, Dollé, Martijn E.T., Public Health Epidemiologie, Other research (not in main researchprogram), Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Rietman, M. Liset, Spijkerman, Annemieke M.W., Wong, Albert, van Steeg, Harry, Bürkle, Alexander, Moreno-Villanueva, María, Sindlinger, Thilo, Franceschi, Claudio, Grubeck-Loebenstein, Beatrix, Bernhardt, Jürgen, Slagboom, P. Eline, Toussaint, Olivier, Debacq-Chainiaux, Florence, Sikora, Ewa, Gonos, Efstathios S., Breusing, Nicolle, Stuetz, Wolfgang, Weber, Daniela, Grune, Tilman, Basso, Andrea, Piacenza, Francesco, Malavolta, Marco, Collino, Sebastiano, Jansen, Eugene H.J.M., Verschuren, W. M.Monique, and Dollé, Martijn E.T.

Published
2019

23. Analysis of the machinery and intermediates of the 5hmC-mediated DNA demethylation pathway in aging on samples from the MARKAGE Study

Author

Valentini, Elisabetta, Zampieri, Michele, Malavolta, Marco, Bacalini, Maria Giulia, Calabrese, Roberta, Guastafierro, Tiziana, Reale, Anna, Franceschi, Claudio, Hervonen, Antti, Koller, Bernhard, Bernhardt, Jürgen, Slagboom, P. Eline, Toussaint, Olivier, Sikora, Ewa, Gonos, Efstathios S, Breusing, Nicolle, Grune, Tilman, Jansen, Eugène, Dollé, Martijn E.T., Moreno-Villanueva, María, Sindlinger, Thilo, Bürkle, Alexander, Ciccarone, Fabio, Caiafa, Paola, Valentini, Elisabetta, Zampieri, Michele, Malavolta, Marco, Bacalini, Maria Giulia, Calabrese, Roberta, Guastafierro, Tiziana, Reale, Anna, Franceschi, Claudio, Hervonen, Antti, Koller, Bernhard, Bernhardt, Jürgen, Eline Slagboom, P., Toussaint, Olivier, Sikora, Ewa, Gonos, Efstathios S., Breusing, Nicolle, Grune, Tilman, Jansen, Eugène, Dollé, Martijn E.T., Moreno-Villanueva, María, Sindlinger, Thilo, Bürkle, Alexander, Ciccarone, Fabio, and Caiafa, Paola

Subjects
0301 basic medicine, DNA Hydroxymethylation, Adult, Male, Aging, Gene Expression, TDG, Biology, Dioxygenases, Mixed Function Oxygenases, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, DNA hydroxymethylation, TET genes, Cell Biology, ddc:570, Proto-Oncogene Proteins, Humans, Epigenetics, Settore BIO/10, Aged, Genetics, Regulation of gene expression, DNA Repair Pathway, DNA Methylation, Middle Aged, 5-Methylcytosine, 030104 developmental biology, DNA demethylation, chemistry, Gene Expression Regulation, genesTET, aging, 030220 oncology & carcinogenesis, DNA methylation, Leukocytes, Mononuclear, TET gene, Female, Thymine-DNA glycosylase, Research Paper
Abstract

Gradual changes in the DNA methylation landscape occur throughout aging virtually in all human tissues. A widespread reduction of 5-methylcytosine (5mC), associated with highly reproducible site-specific hypermethylation, characterizes the genome in aging. Therefore, an equilibrium seems to exist between general and directional deregulating events concerning DNA methylation controllers, which may underpin the age-related epigenetic changes. In this context, 5mC-hydroxylases (TET enzymes) are new potential players. In fact, TETs catalyze the stepwise oxidation of 5mC to 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC), driving the DNA demethylation process based on thymine DNA glycosylase (TDG)-mediated DNA repair pathway. The present paper reports the expression of DNA hydroxymethylation components, the levels of 5hmC and of its derivatives in peripheral blood mononuclear cells of age-stratified donors recruited in several European countries in the context of the EU Project 'MARK-AGE'. The results provide evidence for an age-related decline of TET1, TET3 and TDG gene expression along with a decrease of 5hmC and an accumulation of 5caC. These associations were independent of confounding variables, including recruitment center, gender and leukocyte composition. The observed impairment of 5hmC-mediated DNA demethylation pathway in blood cells may lead to aberrant transcriptional programs in the elderly. published

Published
2016

24. Analysis of the machinery and intermediates of the 5hmC-mediated DNA demethylation pathway in aging on samples from the MARK-AGE Study

Author

Valentini, Elisabetta, primary, Zampieri, Michele, additional, Malavolta, Marco, additional, Bacalini, Maria Giulia, additional, Calabrese, Roberta, additional, Guastafierro, Tiziana, additional, Reale, Anna, additional, Franceschi, Claudio, additional, Hervonen, Antti, additional, Koller, Bernhard, additional, Bernhardt, Jürgen, additional, Slagboom, P. Eline, additional, Toussaint, Olivier, additional, Sikora, Ewa, additional, Gonos, Efstathios S., additional, Breusing, Nicolle, additional, Grune, Tilman, additional, Jansen, Eugène, additional, Dollé, Martijn E.T., additional, Moreno-Villanueva, María, additional, Sindlinger, Thilo, additional, Bürkle, Alexander, additional, Ciccarone, Fabio, additional, and Caiafa, Paola, additional

Published
2016
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25. Obesity and Age-Related Changes in Markers of Oxidative Stress and Inflammation Across Four Generations

Author

Hulsegge, Gerben, primary, Herber-Gast, Gerrie-Cor M., additional, Spijkerman, Annemieke M.W., additional, Susan, H., additional, Picavet, J., additional, van der Schouw, Yvonne T., additional, Bakker, Stephan J.L., additional, Gansevoort, Ron T., additional, Dollé, Martijn E.T., additional, Smit, Henriette A., additional, and Monique Verschuren, W.M., additional

Published
2016
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26. Altered lipid metabolism in the aging kidney identified by three layered omic analysis

Author

Braun, Fabian, primary, Rinschen, Markus M., additional, Bartels, Valerie, additional, Frommolt, Peter, additional, Habermann, Bianca, additional, Hoeijmakers, Jan H.J., additional, Schumacher, Björn, additional, Dollé, Martijn E.T., additional, Müller, Roman-Ulrich, additional, Benzing, Thomas, additional, Schermer, Bernhard, additional, and Kurschat, Christine E., additional

Published
2016
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28. An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA

Author

Demaria, Marco, primary, Ohtani, Naoko, additional, Youssef, Sameh A., additional, Rodier, Francis, additional, Toussaint, Wendy, additional, Mitchell, James R., additional, Laberge, Remi-Martin, additional, Vijg, Jan, additional, Van Steeg, Harry, additional, Dollé, Martijn E.T., additional, Hoeijmakers, Jan H.J., additional, de Bruin, Alain, additional, Hara, Eiji, additional, and Campisi, Judith, additional

Published
2014
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29. Broad segmental progeroid changes in short-lived Ercc1 −/Δ7 mice

Author

Dollé, Martijn E.T., primary, Kuiper, Raoul V., additional, Roodbergen, Marianne, additional, Robinson, Joke, additional, de Vlugt, Sisca, additional, Wijnhoven, Susan W. P., additional, Beems, Rudolf B., additional, de la Fonteyne, Liset, additional, de With, Piet, additional, van der Pluijm, Ingrid, additional, Niedernhofer, Laura J., additional, Hasty, Paul, additional, Vijg, Jan, additional, Hoeijmakers, Jan H.J., additional, and van Steeg, Harry, additional

Published
2011
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30. Mouse Models for the p53 R72P Polymorphism Mimic Human Phenotypes

Author

Zhu, Feng, primary, Dollé, Martijn E.T., additional, Berton, Thomas R., additional, Kuiper, Raoul V., additional, Capps, Carrie, additional, Espejo, Alexsandra, additional, McArthur, Mark J., additional, Bedford, Mark T., additional, van Steeg, Harry, additional, de Vries, Annemieke, additional, and Johnson, David G., additional

Published
2010
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31. Proteins of nucleotide and base excision repair pathways interact in mitochondria to protect from loss of subcutaneous fat, a hallmark of aging

Author

Kamenisch, York, primary, Fousteri, Maria, additional, Knoch, Jennifer, additional, von Thaler, Anna-Katharina, additional, Fehrenbacher, Birgit, additional, Kato, Hiroki, additional, Becker, Thomas, additional, Dollé, Martijn E.T., additional, Kuiper, Raoul, additional, Majora, Marc, additional, Schaller, Martin, additional, van der Horst, Gijsbertus T.J., additional, van Steeg, Harry, additional, Röcken, Martin, additional, Rapaport, Doron, additional, Krutmann, Jean, additional, Mullenders, Leon H., additional, and Berneburg, Mark, additional

Published
2010
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34. Broad segmental progeroid changes in short-lived Ercc1-/Δ7 mice.

Author

Dollé, Martijn E.T., Kuiper, Raoul V., Roodbergen, Marianne, Robinson, Joke, de Vlugt, Sisca, Wijnhoven, Susan W. P., Beems, Rudolf B., de la Fonteyne, Liset, de With, Piet, van der Pluijm, Ingrid, Niedernhofer, Laura J., Hasty, Paul, Vijg, Jan, Hoeijmakers, Jan H.J., and van Steeg, Harry

Subjects
*AGING, *LABORATORY mice, *BODY weight, *LIFE spans, *CROSS-sectional method
Abstract

Genome maintenance is considered a prime longevity assurance mechanism as apparent from many progeroid human syndromes that are caused by genome maintenance defects. The ERCC1 protein is involved in three genome maintenance systems: nucleotide excision repair , interstrand cross-link repair, and homologous recombination. Here we describe in-life and post-mortem observations for a hypomorphic Ercc1 variant, Ercc1-/Δ7, which is hemizygous for a single truncated Ercc1 allele, encoding a protein lacking the last seven amino acids. Ercc1 mice-/Δ7 were much smaller and median life span was markedly reduced compared to wild-type siblings: 20 and 118 weeks, respectively. Multiple signs and symptoms of aging were found to occur at an accelerated rate in the Ercc1-/Δ7 mice as compared to wild-type controls, including a decline in weight of both whole body and various organs, numerous histopathological lesions, and immune parameters. Together they define a segmental progeroid phenotype of the Ercc1-/Δ7 mouse model. [ABSTRACT FROM AUTHOR]

Published
2011
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35. Quality control data of physiological and immunological biomarkers measured in serum and plasma

Author

Nicolle Breusing, Ewa Sikora, Alexander Bürkle, Eugène H.J.M. Jansen, Piet Beekhof, Maria Moreno-Villanueva, Miriam Capri, Tilman Grune, Jürgen Bernhard, Birgit Weinberger, Claudio Franceschi, Efstathios S. Gonos, Simone Fiegl, Martijn E.T. Dollé, Johannes W J M Cremers, Olivier Toussaint, Jansen, Eugène, Beekhof, Piet, Cremers, Johanne, Weinberger, Birgit, Fiegl, Simone, Toussaint, Olivier, Bernhard, Jürgen, Gonos, Efstathio, Capri, Miriam, Franceschi, Claudio, Sikora, Ewa, Moreno-Villanueva, María, Breusing, Nicolle, Grune, Tilman, Bürkle, Alexander, and Dollé, Martijn E.T.

Subjects
Male, Hemolysi, Aging, Work package, Coefficient of variation, Sample (material), 030204 cardiovascular system & hematology, Hemolysis, 03 medical and health sciences, 0302 clinical medicine, Animal science, ddc:570, Data accuracy, Control data, Humans, Medicine, 030304 developmental biology, 0303 health sciences, Plasma samples, business.industry, Quality control, Biomarker, medicine.disease, Data Accuracy, Ageing, Immunology, Biomarker (medicine), Female, business, Biomarkers, Developmental Biology
Abstract

In two work packages of the MARK-AGE project, 37 immunological and physiological biomarkers were measured in 3637 serum, plasma or blood samples in five batches during a period of 4 years.The quality of the serum and plasma samples was very good as judged by the low number of biomarker measurements (only 0.2%) that were rejected because of a high hemolysis, icteria or lipemia of the samples.Using quality control samples, day-to-day and batch variations were determined. The mean inter-assay variation of the five batches were all below 8%, with an average inter-assay coefficient of variation of all biomarkers of 4.0%. Also the precision of the measurements was very good, because all measurements were between 90% and 115% of the defined target values.A possible mix-up of samples was determined by comparison of the extreme testosterone levels of men and women. It was concluded that 3% of the sample identification could be mixed-up.Considering the complex procedure from collection to analysis, including preparation, handling, shipment and storage, of the samples in the MARK-AGE project, both the quality of the samples and the quality of the measurements are very good. published

Published
2015
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