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4. A CRISPR RNA Is Closely Related With the Size of the Cascade Nucleoprotein Complex

Author

Do-Heon Gu, Sung Chul Ha, and Jeong-Sun Kim

Subjects
CRISPR, cascade, Csy3, helical backbone, crRNA, Microbiology, QR1-502
Abstract

The currently known prokaryotic adaptive immune system against mobile genetic elements is based on clustered regularly interspaced short palindromic repeats (CRISPR). CRISPR-associated (Cas) proteins and the transcribed short CRISPR RNA (crRNA) molecule form a heterologous ribonucleoprotein complex that neutralizes invading foreign nucleic acids, wherein the crRNA molecule base-pairs with the exogenous genetic elements. In the ribonucleoprotein complexes of the type I CRISPR system, a helical backbone of six identical subunits is commonly found. However, it is not clear how this ribonucleoprotein complex is assembled and what is the determinant factor for its size. We elucidated the crystal structure of the Csy3 subunit of the type I-F ribonucleoprotein complex from Zymomonas mobilis (ZmCsy3), in which seven ZmCsy3 protomers in the asymmetric unit form a molecular helix that is part of a filamentous structure in the entire crystal system. This ZmCsy3 helical structure is remarkably similar to the crRNA-bound hexameric Csy3 backbone from Pseudomonas aeruginosa, with conserved interactions between neighboring subunits. The monomeric ZmCsy3 in solution is transformed into different oligomeric states depending on the added crRNAs. These results suggest that a crRNA and Csy3 subunit play a determinant role in the stepwise formation of the functional Cascade ribonucleoprotein complex and the recruitment of other subunits, and crRNA functions as a molecular ruler for determining the size of the Cascade silencing complex.

Published
2019
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7. BL-11C Micro-MX: a high-flux microfocus macromolecular-crystallography beamline for micrometre-sized protein crystals at Pohang Light Source II

Author

Chae Soon Lee, Sung Chul Ha, Jinhong Kim, Suk Youl Park, Cheolsoo Eo, Seungyu Rah, Hyo-Yun Kim, Do Heon Gu, Jeong-Sun Kim, Jun Lim, Seung A Hwangbo, Young Duck Yun, Hyeongju Choi, Jangwoo Kim, Jie Oh Lee, In Deuk Seo, W. Lee, and Yeon Gil Kim

Subjects
Nuclear and High Energy Physics, Materials science, Macromolecular Substances, 030303 biophysics, Legionella, Crystal structure, Neisseria meningitidis, Crystallography, X-Ray, 03 medical and health sciences, Optics, macromolecular crystallography, serial crystallography, Carbon Radioisotopes, Instrumentation, 030304 developmental biology, Zymomonas, 0303 health sciences, Radiation, business.industry, Detector, Proteins, Beamlines, Equipment Design, Undulator, Beamline, microfocus, Goniometer, protein structures, X-ray crystallography, Muramidase, Protein Structural Elements, business, Protein crystallization, Synchrotrons, Beam (structure)
Abstract

A new protein crystallography beamline (BL-11C) has been constructed at Pohang Light Source II. The BL-11C beamline allows routine protein-structure determinations under a robot sample-mounting system and room-temperature structure determinations through synchrotron serial crystallography experiments., BL-11C, a new protein crystallography beamline, is an in-vacuum undulator-based microfocus beamline used for macromolecular crystallography at the Pohang Accelerator Laboratory and it was made available to users in June 2017. The beamline is energy tunable in the range 5.0–20 keV to support conventional single- and multi-wavelength anomalous-dispersion experiments against a wide range of heavy metals. At the standard working energy of 12.659 keV, the monochromated beam is focused to 4.1 µm (V) × 8.5 µm (H) full width at half-maximum at the sample position and the measured photon flux is 1.3 × 1012 photons s−1. The experimental station is equipped with a Pilatus3 6M detector, a micro-diffractometer (MD2S) incorporating a multi-axis goniometer, and a robotic sample exchanger (CATS) with a dewar capacity of 90 samples. This beamline is suitable for structural determination of weakly diffracting crystalline substances, such as biomaterials, including protein, nucleic acids and their complexes. In addition, serial crystallography experiments for determining crystal structures at room temperature are possible. Herein, the current beamline characteristics, technical information for users and some recent scientific highlights are described.

Published
2021
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8. Dual Oxidase 2 (DUOX2) as a Proteomic Biomarker for Predicting Treatment Response to Chemoradiation Therapy for Locally Advanced Rectal Cancer: Using High-Throughput Proteomic Analysis and Machine Learning Algorithm

Author

Lee, Hyebin, primary, Ryu, Han Suk, additional, Park, Hee Chul, additional, Yu, Jeong Il, additional, Yoo, Gyu Sang, additional, Choi, Changhoon, additional, Nam, Heerim, additional, Lee, Jason Joon Bock, additional, Do, In-Gu, additional, Han, Dohyun, additional, and Ha, Sang Yun, additional

Published
2022
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10. Molecular analysis of gastric cancer identifies subtypes associated with distinct clinical outcomes

Author

Cristescu, Razvan, Lee, Jeeyun, Nebozhyn, Michael, Kim, Kyoung-Mee, Ting, Jason C., Wong, Swee Seong, Liu, Jiangang, Yue, Yong Gang, Wang, Jian, Yu, Kun, Ye, Xiang S., Do, In-Gu, Liu, Shawn, Gong, Lara, Fu, Jake, Jin, Jason Gang, Choi, Min Gew, Sohn, Tae Sung, Lee, Joon Ho, Bae, Jae Moon, Kim, Seung Tae, Park, Se Hoon, Sohn, Insuk, Jung, Sin-Ho, Tan, Patrick, Chen, Ronghua, Hardwick, James, Kang, Won Ki, Ayers, Mark, Hongyue, Dai, Reinhard, Christoph, Loboda, Andrey, Kim, Sung, and Aggarwal, Amit

Subjects
Gene expression -- Health aspects, Tumor proteins -- Identification and classification, Stomach cancer -- Genetic aspects -- Development and progression, Biological sciences, Health
Abstract

Gastric cancer, a leading cause of cancer-related deaths, is a heterogeneous disease. We aim to establish clinically relevant molecular subtypes that would encompass this heterogeneity and provide useful clinical information. We use gene expression data to describe four molecular subtypes linked to distinct patterns of molecular alterations, disease progression and prognosis. The mesenchymal-like type includes diffuse-subtype tumors with the worst prognosis, the tendency to occur at an earlier age and the highest recurrence frequency (63%) of the four subtypes. Microsatellite-unstable tumors are hyper-mutated intestinal-subtype tumors occurring in the antrum; these have the best overall prognosis and the lowest frequency of recurrence (22%) of the four subtypes. The tumor protein 53 (TP53)-active and [TP53.sup.-]inactive types include patients with intermediate prognosis and recurrence rates (with respect to the other two subtypes), with the [TP53.sup.-]active group showing better prognosis. We describe key molecular alterations in each of the four subtypes using targeted sequencing and genome-wide copy number microarrays. We validate these subtypes in independent cohorts in order to provide a consistent and unified framework for further clinical and preclinical translational research., Gastric cancer (GC) is the fourth-most-common cancer globally and the second-leading cause of cancer deaths (1). It accounts for 989,600 cases annually, with East Asia accounting for more than half [...]

Published
2015
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13. Preexisting oncogenic events impact trastuzumab sensitivity in ERBB2-amplified gastroesophageal adenocarcinoma

Author

Kim, Jihun, Fox, Cameron, Peng, Shouyong, Pusung, Mark, Pectasides, Eirini, Matthee, Eric, Hong, Yong Sang, Do, In-Gu, Jang, Jiryeon, Thorner, Aaron R., Van Hummelen, Paul, Rustgi, Anil K., Wong, Kwok-Kin, Zhou, Zhongren, Tang, Ping, Kim, Kyoung-Mee, Lee, Jeeyun, and Bass, Adam J.

Subjects
Oncogenes -- Physiological aspects -- Research, Esophageal cancer -- Drug therapy -- Genetic aspects -- Research, Health care industry
Abstract

Patients with gastric and esophageal (GE) adenocarcinoma tumors in which the oncogene ERBB2 has been amplified are routinely treated with a combination of cytotoxic chemotherapy and the ERBB2-directed antibody trastuzumab; however, the addition of trastuzumab, even when tested in a selected biomarker-positive patient population, provides only modest survival gains. To investigate the potential reasons for the modest impact of ERBB2-directed therapies, we explored the hypothesis that secondary molecular features of ERBB2-amplified GE adenocarcinomas attenuate the impact of ERBB2 blockade. We analyzed genomic profiles of ERBB2-amplified GE adenocarcinomas and determined that the majority of ERBB2-amplified tumors harbor secondary oncogenic alterations that have the potential to be therapeutically targeted. These secondary events spanned genes involved in cell-cycle regulation as well as phosphatidylinositol-3 kinase and receptor tyrosine kinase signaling. Using ERBB2-amplified cell lines, we demonstrated that secondary oncogenic events could confer resistance to ERBB2-directed therapies. Moreover, this resistance could be overcome by targeting the secondary oncogene in conjunction with ERBB2-directed therapy. EGFR is commonly coamplified with ERBB2, and in the setting of ERBB2 amplification, higher EGFR expression appears to mark tumors with greater sensitivity to dual EGFR/ERBB2 kinase inhibitors. These data suggest that combination inhibitor strategies, guided by secondary events in ERBB2-amplified GE adenocarcinomas, should be evaluated in clinical trials., Introduction Gastric adenocarcinoma is the fourth most common cancer and the third leading cause of cancer deaths worldwide, and the incidence of esophageal adenocarcinoma is increasing dramatically in many Western [...]

Published
2014
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15. Analysis of Trends in Regulatory Science and Regulatory Science Experts Training Projects: US, Japan, Singapore, and Korea

Author

Park, Jaehong, primary, Shin, Hocheol, additional, Kim, Jiwon, additional, Kim, Minsu, additional, Do, In Gu, additional, Lim, Heeyeon, additional, Lee, Jiwon, additional, Lee, Yun-ji, additional, Jung, Sun-Young, additional, Kang, Wonku, additional, Kim, Hahyung, additional, Choi, Young Wook, additional, and Kim, Eunyoung, additional

Published
2021
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20. Structures of Zymomonas 2-Keto-3-Deoxy-6-Phosphogluconate Aldolase with and without a Substrate Analog at the Phosphate-Binding Loop

Author

Suk-Youl Park, Hee-Sae Park, Pil-Won Seo, Ho-Chang Ryu, Do-Heon Gu, and Jeong-Sun Kim

Subjects
0301 basic medicine, biology, Stereochemistry, Aldolase A, General Medicine, Substrate analog, Condensation reaction, biology.organism_classification, Applied Microbiology and Biotechnology, Zymomonas mobilis, Serine, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, Protein structure, Aldol reaction, chemistry, biology.protein, Binding site, Biotechnology
Abstract

2-Keto-3-deoxy-6-phosphogluconate (KDPG) aldolase, which catalyzes aldol cleavage and condensation reactions, has two distinct substrate-binding sites. The substrate-binding mode at the catalytic site and Schiff-base formation have been well studied. However, structural information on the phosphate-binding loop (P-loop) is limited. Zymomonas mobilis KDPG aldolase is one of the aldolases with a wide substrate spectrum. Its structure in complex with the substrate-mimicking 3-phosphoglycerate (3PG) shows that the phosphate moiety of 3PG interacts with the P-loop and a nearby conserved serine residue. 3PG-binding to the P-loop replaces water molecules aligned from the P-loop to the catalytic site, as observed in the apo-structure. The extra electron density near the P-loop and comparison with other aldolases suggest the diversity and flexibility of the serine-containing loop among KDPG aldolases. These structural data may help to understand the substrate-binding mode and the broad substrate specificity of the Zymomonas KDPG aldolase.

Published
2018
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21. Clinicopathological characteristics and outcomes of gastrointestinal stromal tumors with high progranulin expression

Author

Do, In-Gu, primary, Jung, Kyung Uk, additional, Koo, Dong-Hoe, additional, Lee, Yun-Gyoo, additional, Oh, Sukjoong, additional, Kim, Kyungeun, additional, Kim, Dong-Hoon, additional, Sohn, Jin Hee, additional, Son, Byung Ho, additional, Lee, Sung Ryol, additional, Shin, Jun Ho, additional, Kim, Hyung Ook, additional, Kim, Hungdai, additional, Chun, Ho-Kyung, additional, Serrero, Ginette, additional, and Yoo, Chang Hak, additional

Published
2021
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23. Beyond PS-LTE: Security Model Design Framework for PPDR Operational Environment

Author

Do Hyung Gu, Daegeon Kim, and Huy Kang Kim

Subjects
FOS: Computer and information sciences, National security, Science (General), Computer Science - Cryptography and Security, Article Subject, Computer Networks and Communications, Computer science, 02 engineering and technology, Computer security, computer.software_genre, Q1-390, 0202 electrical engineering, electronic engineering, information engineering, T1-995, Technology (General), Design framework, Emergency management, Event (computing), business.industry, 020206 networking & telecommunications, Computer security model, Public protection, Systems architecture, 020201 artificial intelligence & image processing, Mobile communication network, business, computer, Cryptography and Security (cs.CR), Information Systems
Abstract

National disasters can threaten national security and require several organizations to integrate the functionalities to correspond to the event. Many countries are constructing a nationwide mobile communication network infrastructure to share information and promptly communicate with corresponding organizations. Public Safety Long-Term Evolution (PS-LTE) is a communication mechanism adopted in many countries to achieve such a purpose. Organizations can increase the efficiency of public protection and disaster relief (PPDR) operations by securely connecting the services run on their legacy networks to the PS-LTE infrastructure. This environment allows the organizations to continue facilitating the information and system functionalities provided by the legacy network. The vulnerabilities in the environment, which differ from commercial LTE, need to be resolved to connect the network securely. In this study, we propose a security model design framework to derive the system architecture and the security requirements targeting the restricted environment applied by certain technologies for a particular purpose. After analyzing the PPDR operation environment’s characteristics under the PS-LTE infrastructure, we applied the framework to derive the security model for organizations using PPDR services operated in their legacy networks through this infrastructure. Although the proposed security model design framework is applied to the specific circumstance in this research, it can be generally adopted for the application environment.

Published
2020
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24. A CRISPR RNA Is Closely Related With the Size of the Cascade Nucleoprotein Complex

Author

Jeong-Sun Kim, Sung Chul Ha, and Do-Heon Gu

Subjects
Trans-activating crRNA, Microbiology (medical), 0303 health sciences, Csy3, 030306 microbiology, Chemistry, Protein subunit, lcsh:QR1-502, RNA, Microbiology, helical backbone, lcsh:Microbiology, Cell biology, Nucleoprotein, cascade, 03 medical and health sciences, CRISPR, Nucleic acid, Mobile genetic elements, crRNA, 030304 developmental biology, Ribonucleoprotein, Original Research
Abstract

The currently known prokaryotic adaptive immune system against mobile genetic elements is based on clustered regularly interspaced short palindromic repeats (CRISPR). CRISPR-associated (Cas) proteins and the transcribed short CRISPR RNA (crRNA) molecule form a heterologous ribonucleoprotein complex that neutralizes invading foreign nucleic acids, wherein the crRNA molecule base-pairs with the exogenous genetic elements. In the ribonucleoprotein complexes of the type I CRISPR system, a helical backbone of six identical subunits is commonly found. However, it is not clear how this ribonucleoprotein complex is assembled and what is the determinant factor for its size. We elucidated the crystal structure of the Csy3 subunit of the type I-F ribonucleoprotein complex from Zymomonas mobilis (ZmCsy3), in which seven ZmCsy3 protomers in the asymmetric unit form a molecular helix that is part of a filamentous structure in the entire crystal system. This ZmCsy3 helical structure is remarkably similar to the crRNA-bound hexameric Csy3 backbone from Pseudomonas aeruginosa, with conserved interactions between neighboring subunits. The monomeric ZmCsy3 in solution is transformed into different oligomeric states depending on the added crRNAs. These results suggest that a crRNA and Csy3 subunit play a determinant role in the stepwise formation of the functional Cascade ribonucleoprotein complex and the recruitment of other subunits, and crRNA functions as a molecular ruler for determining the size of the Cascade silencing complex.

Published
2019

25. Structures of

Author

Pil-Won, Seo, Ho-Chang, Ryu, Do-Heon, Gu, Hee-Sae, Park, Suk-Youl, Park, and Jeong-Sun, Kim

Subjects
Models, Molecular, Zymomonas, AAA Domain, Binding Sites, Protein Conformation, Catalytic Domain, Crystallography, X-Ray, Databases, Protein, Glyceric Acids, Sequence Alignment, Recombinant Proteins, Aldehyde-Lyases, Substrate Specificity
Abstract

2-Keto-3-deoxy-6-phosphogluconate (KDPG) aldolase, which catalyzes aldol cleavage and condensation reactions, has two distinct substrate-binding sites. The substrate-binding mode at the catalytic site and Schiff-base formation have been well studied. However, structural information on the phosphate-binding loop (P-loop) is limited.

Published
2018

26. BioPATH: A Biomarker Study in Asian Patients with HER2+ Advanced Breast Cancer Treated with Lapatinib and Other Anti-HER2 Therapy

Author

Kim, Sung-Bae, primary, Do, In-Gu, additional, Tsang, Janice, additional, Kim, Tae-You, additional, Yap, Yoon-Sim, additional, Cornelio, Gerardo, additional, Gong, Gyungyub, additional, Paik, Soonmyung, additional, Lee, Suee, additional, Ng, Ting-Ying, additional, Park, Sarah, additional, Oh, Ho-Suk, additional, Chiu, Joanne, additional, Sohn, Joohyuk, additional, Lee, Moonhee, additional, Choi, Young-Jin, additional, Lee, Eun Mi, additional, Park, Kyong-Hwa, additional, Nathaniel, Christos, additional, and Ro, Jungsil, additional

Published
2019
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29. Expression of nicotinamide N-methyltransferase in hepatocellular carcinoma is associated with poor prognosis

Author

Do In-Gu, Roh Ji, Kim Seung, Yu Yun-Suk, Lim Eun, Hong Seok, Kim Jongmin, Joh Jae-Won, and Kim Dae

Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background Hepatocellular carcinoma (HCC) is the most common tumor in the adult liver, with high relapse and mortality rates despite diverse treatment modalities. In this study, nicotinamide N-methyltransferase (NNMT), a key enzyme in drug metabolism, was investigated as a potential prognostic factor. Methods Frozen tumors and non-cancerous surrounding tissues from 120 patients with primary HCC were studied. Expressions of NNMT and internal control genes were measured by real-time reverse-transcription PCR (RT-PCR). The relationship of NNMT mRNA level with clinicopathologic parameters and clinical outcome was evaluated. Results NNMT mRNA level is markedly reduced in HCCs compared to non-cancerous surrounding tissues (P < 0.0001), and NNMT expression in tumors was significantly correlated with tumor stage (P = 0.010). Moreover, stratification of patients based on tumor NNMT mRNA levels revealed that the patients who expressed higher NNMT mRNA levels tended to have a shorter overall survival (OS) time (P = 0.053) and a significantly shorter disease-free survival (DFS) time (P = 0.016). Both NNMT expression (P = 0.0096) and tumor stage (P = 0.0017) were found to be significant prognostic factors for DFS in a multivariate analysis. Conclusion The results of this study indicated that NNMT gene expression is associated with tumor stage and DFS time in HCC cases. Because of the broad substrate specificity of NNMT, which could alter the efficacy and adverse effects of chemotherapy, NNMT merits further investigation regarding its role as a prognostic factor with a larger cohort of HCC patients.

Published
2009
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30. Diagnostic performance and useful findings of ultrasound re-evaluation for patients with equivocal CT features of acute appendicitis

Author

Kim, Mi Sung, Kwon, Heon-Ju, Kang, Kyung A, Do, In-Gu, Park, Hee-Jin, Kim, Eun Young, Hong, Hyun Pyo, Choi, Yoon Jung, and Kim, Young Hwan

Subjects
Adult, Aged, 80 and over, Male, Full Paper, Adolescent, Middle Aged, Appendicitis, Multimodal Imaging, Sensitivity and Specificity, Young Adult, Child, Preschool, Humans, Female, Child, Tomography, X-Ray Computed, Aged, Retrospective Studies, Ultrasonography
Abstract

To evaluate the diagnostic performance of ultrasound and to determine which ultrasound findings are useful to differentiate appendicitis from non-appendicitis in patients who underwent ultrasound re-evaluation owing to equivocal CT features of acute appendicitis.62 patients who underwent CT examinations for suspected appendicitis followed by ultrasound re-evaluation owing to equivocal CT findings were included. Equivocal CT findings were considered based on the presence of only one or two findings among the CT criteria, and ultrasound re-evaluation was done based on a predefined structured report form. The diagnostic performance of ultrasound and independent variables to discriminate appendicitis from non-appendicitis were assessed.There were 27 patients in the appendicitis group. The overall diagnostic performance of ultrasound re-evaluation was sensitivity of 96.3%, specificity of 91.2% and accuracy of 91.9%. In terms of the performance of individual ultrasound findings, probe-induced tenderness showed the highest accuracy (86.7%) with sensitivity of 74% and specificity of 97%, followed by non-compressibility (accuracy 71.7%, sensitivity 85.2% and specificity 60.6%). The independent ultrasound findings for discriminating appendicitis were non-compressibility (p = 0.002) and increased flow on the appendiceal wall (p = 0.001).Ultrasound re-evaluation can be used to improve diagnostic accuracy in cases with equivocal CT features for diagnosing appendicitis. The presence of non-compressibility and increased vascular flow on the appendix wall are useful ultrasound findings to discriminate appendicitis from non-appendicitis. Advances in knowledge: Ultrasound re-evaluation is useful to discriminate appendicitis from non-appendicitis when CT features are inconclusive.

Published
2018

33. Overexpression of cytokeratin 17 is associated with the development of papillary thyroid carcinoma and the presence of lymph node metastasis

Author

Kim, Hyun-Soo, Lee, Jeong-Ju, Do, Sung-Im, Kim, Kyungeun, Do, In-Gu, Kim, Dong-Hoon, Chae, Seoung Wan, and Sohn, Jin Hee

Subjects
Adult, Male, Keratin-17, endocrine system diseases, Carcinoma, Middle Aged, Immunohistochemistry, Carcinoma, Papillary, Up-Regulation, Young Adult, Thyroid Cancer, Papillary, Tissue Array Analysis, Lymphatic Metastasis, Biomarkers, Tumor, Humans, Original Article, Female, Thyroid Neoplasms, Aged, Retrospective Studies
Abstract

Cytokeratin 17 (CK17), a basal/myoepithelial cell keratin, appears to play an important role in the progression of several human malignancies. Increased CK17 expression has previously described in cases of papillary thyroid carcinoma (PTC). However, no studies to date have investigated the clinical significance of CK17 expression in patients with PTC. The aim of this study was to compare the expression of CK17 in patients with PTC with that observed in normal thyroid tissue and benign thyroid lesions, and to examine the relationship between CK17 expression and clinicopathologic characteristics of patients with PTC. CK17 protein expression was evaluated by immunohistochemistry on tissue microarrays containing thyroid tissue samples from 108 PTCs, 16 nodular goiters, and 81 healthy controls. Sixty-five of the 108 (60.2%) PTC tissue samples exhibited positive CK17 expression, whereas all nodular goiters and normal thyroid tissue samples showed a complete absence of CK17 immunoreactivity. The difference in frequency of CK17 positivity between PTC (65/108, 60.2%), normal thyroid tissue (0/81, 0.0%), and benign thyroid lesions (0/16, 0.0%) was statistically significant (P

Published
2015

36. Prognostic significance of survivin in rectal cancer patients treated with surgery and postoperative concurrent chemo-radiation therapy

Author

Il Yu, Jeong, primary, Lee, Hyebin, additional, Park, Hee Chul, additional, Choi, Doo Ho, additional, Choi, Yoon-La, additional, Do, In-Gu, additional, Kim, Hee Cheol, additional, Lee, Woo Yong, additional, Yun, Seong Hyeon, additional, Cho, Yong Beom, additional, Huh, Jung Wook, additional, Park, Yoon Ah, additional, Park, Young Suk, additional, Park, Joon Oh, additional, Kim, Seung Tae, additional, and Park, Won, additional

Published
2016
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37. Gene Expression Profiling of Breast Cancer Brain Metastasis

Author

Lee, Ji Yun, primary, Park, Kyunghee, additional, Lee, Eunjin, additional, Ahn, TaeJin, additional, Jung, Hae Hyun, additional, Lim, Sung Hee, additional, Hong, Mineui, additional, Do, In-Gu, additional, Cho, Eun Yoon, additional, Kim, Duk-Hwan, additional, Kim, Ji-Yeon, additional, Ahn, Jin Seok, additional, Im, Young-Hyuck, additional, and Park, Yeon Hee, additional

Published
2016
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39. Mutational profiling of brain metastasis from breast cancer: matched pair analysis of targeted sequencing between brain metastasis and primary breast cancer

Author

Lee, Ji Yun, primary, Park, Kyunghee, additional, Lim, Sung Hee, additional, Kim, Hae Su, additional, Yoo, Kwai Han, additional, Jung, Ki Sun, additional, Song, Haa-Na, additional, Hong, Mineui, additional, Do, In-Gu, additional, Ahn, TaeJin, additional, Lee, Se Kyung, additional, Bae, Soo Youn, additional, Kim, Seok Won, additional, Lee, Jeong Eon, additional, Nam, Seok Jin, additional, Kim, Duk-Hwan, additional, Jung, Hae Hyun, additional, Kim, Ji-Yeon, additional, Ahn, Jin Seok, additional, Im, Young-Hyuck, additional, and Park, Yeon Hee, additional

Published
2015
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40. Exploratory biomarker analysis for treatment response in KRAS wild type metastatic colorectal cancer patients who received cetuximab plus irinotecan

Author

Kim, Seung Tae, primary, Ahn, Tae Jin, additional, Lee, Eunjin, additional, Do, In-Gu, additional, Lee, Su Jin, additional, Park, Se Hoon, additional, Park, Joon Oh, additional, Park, Young Suk, additional, Lim, Ho Yeong, additional, Kang, Won Ki, additional, Kim, Suk Hyeong, additional, Lee, Jeeyun, additional, and Kim, Hee Cheol, additional

Published
2015
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41. Proton pump inhibitors enhance the effects of cytotoxic agents in chemoresistant epithelial ovarian carcinoma

Author

Lee, Yoo-Young, primary, Jeon, Hye-Kyung, additional, Hong, Ji Eun, additional, Cho, Young Jae, additional, Ryu, Ji Yoon, additional, Choi, Jung-Joo, additional, Lee, Sang Hoon, additional, Yoon, Gun, additional, Kim, Woo Young, additional, Do, In-Gu, additional, Kim, Min Kyu, additional, Kim, Tae-Joong, additional, Choi, Chel Hun, additional, Lee, Jeong-Won, additional, Bae, Duk-Soo, additional, and Kim, Byoung-Gie, additional

Published
2015
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42. Role of HER2 mutations in refractory metastatic breast cancers: targeted sequencing results in patients with refractory breast cancer

Author

Park, Yeon Hee, primary, Shin, Hyun-Tae, additional, Jung, Hae Hyun, additional, Choi, Yoon-La, additional, Ahn, TaeJin, additional, Park, Kyunghee, additional, Lee, Aeri, additional, Do, In-Gu, additional, Kim, Ji-Yeon, additional, Ahn, Jin Seok, additional, Park, Woong-Yang, additional, and Im, Young-Hyuck, additional

Published
2015
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43. Patient-derived cell models as preclinical tools for genome-directed targeted therapy

Author

Lee, Ji Yun, primary, Kim, Sun Young, additional, Park, Charny, additional, Kim, Nayoung K.D., additional, Jang, Jiryeon, additional, Park, Kyunghee, additional, Yi, Jun Ho, additional, Hong, Mineui, additional, Ahn, Taejin, additional, Rath, Oliver, additional, Schueler, Julia, additional, Kim, Seung Tae, additional, Do, In-Gu, additional, Lee, Sujin, additional, Park, Se Hoon, additional, Ji, Yong Ick, additional, Kim, Dukwhan, additional, Park, Joon Oh, additional, Park, Young Suk, additional, Kang, Won Ki, additional, Kim, Kyoung-Mee, additional, Park, Woong-Yang, additional, Lim, Ho Yeong, additional, and Lee, Jeeyun, additional

Published
2015
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44. Detection of novel and potentially actionable anaplastic lymphoma kinase (ALK) rearrangement in colorectal adenocarcinoma by immunohistochemistry screening

Author

Lee, Jeeyun, primary, Kim, Hee Cheol, additional, Hong, Jung Yong, additional, Wang, Kai, additional, Kim, Sun Young, additional, Jang, Jiryeon, additional, Kim, Seung Tae, additional, Park, Joon Oh, additional, Lim, Ho Yeong, additional, Kang, Won Ki, additional, Park, Young Suk, additional, Lee, Jiyun, additional, Lee, Woo Yong, additional, Park, Yoon Ah, additional, Huh, Jung Wook, additional, Yun, Seong Hyeon, additional, Do, In-Gu, additional, Kim, Seok Hyung, additional, Balasubramanian, Sohail, additional, Stephens, Philip J., additional, Ross, Jeffrey S., additional, Li, Gang Gary, additional, Hornby, Zachary, additional, Ali, Siraj M., additional, Miller, Vincent A., additional, Kim, Kyoung-Mee, additional, and Ou, Sai-Hong Ignatius, additional

Published
2015
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46. Molecular characterization of patients with pathologic complete response or early failure after neoadjuvant chemotherapy for locally advanced breast cancer using next generation sequencing and nCounter assay

Author

Park, Kyunghee, primary, Choi, Moon Ki, additional, Jung, Hae Hyun, additional, Do, In-Gu, additional, Lee, Kwang Hee, additional, Ahn, TaeJin, additional, Kil, Won Ho, additional, Kim, Seok Won, additional, Lee, Jeong Eon, additional, Nam, Seok Jin, additional, Kim, Duk-Hwan, additional, Ahn, Jin Seok, additional, Im, Young-Hyuck, additional, and Park, Yeon Hee, additional

Published
2015
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47. Abstract P3-06-20: A seven-gene signature can predict distant recurrence in patients with triple-negative breast cancers (TNBCs) who receive adjuvant chemotherapy following curative surgery of the primary breast cancer

Author

Park, Yeon Hee, primary, Jung, Hae Hyun, additional, Do, In-Gu, additional, Cho, Eun Yoon, additional, Sohn, Insuk, additional, Jung, Sin-Ho, additional, Kil, Won Ho, additional, Kim, Seok Won, additional, Lee, Jeong Eon, additional, Nam, Seok Jin, additional, Ahn, Jin Seok, additional, and Im, Young-Hyuck, additional

Published
2015
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48. Abstract P3-06-44: ALK and BRAF genes are associated with early failure of breast cancer (BC) who received primary neoadjuvant chemotherapy for patients with locally advanced BCs

Author

Park, Yeon Hee, primary, Choi, Moon Ki, additional, Do, In-Gu, additional, Choi, Eun Yoon, additional, Kil, Won Ho, additional, Kim, Seok Won, additional, Lee, Jeong Eon, additional, Nam, Seok Jin, additional, Ahn, Jin Seok, additional, and Im, Young-Hyuck, additional

Published
2015
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49. MerTK is a novel therapeutic target in gastric cancer

Author

Yi, Jun Ho, primary, Jang, Jiryeon, additional, Cho, Jeonghee, additional, Do, In-Gu, additional, Hong, Mineui, additional, Kim, Seung Tae, additional, Kim, Kyoung-Mee, additional, Lee, Sujin, additional, Park, Se Hoon, additional, Park, Joon Oh, additional, Park, Young Suk, additional, Kang, Won Ki, additional, Lim, Ho Yeong, additional, and Lee, Jeeyun, additional

Published
2015
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