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Kósmos. ISBN 978-989-640-258-7. P. ...- ....

Simulators have been increasingly used on development and tests on several areas. They allow to speed up the development without damage and no extra costs. On realistic simulators, where kinematics play an important role, the modelling process should be imported for each component to be accurately simulated. Some robots are not yet modelled, as for example the Monera. This paper presents a model of a small vibration robot (Monera) that is acquired in a developed testbed. A localisation ground truth is used to acquire the position of the Monera with actuating it. Linear and angular speeds acquired from real experiments allow to validate the proposed methodology. This work has been supported by FCT - Fundação para a Ciência e Tecnologia within the Project Scope: UIDB/05757/2020 and also by National Funds through the Portuguese funding agency, FCT - Fundação para a Ciência e a Tecnologia, within project LA/P/0063/2020. info:eu-repo/semantics/publishedVersion

There is an increasing need for autonomous mobile robots (AMRs) in industrial environments. The capability of autonomous movement and transportation of items in industrial environments provides a significant increase in productivity and efficiency. This need, coupled with the possibility of controlling groups of heterogeneous robots, simultaneously addresses a wide range of tasks with different characteristics in the same environment, further increasing productivity and efficiency. This paper will present an implementation of a system capable of coordinating a fleet of heterogeneous robots with robustness. The implemented system must be able to plan a safe and efficient path for these different robots. To achieve this task, the TEA* (Time Enhanced A*) graph search algorithm will be used to coordinate the paths of the robots, along with a graph decomposition module that will be used to improve the efficiency and safety of this system. The project was implemented using the ROS framework and the Stage simulator. Results validate the proposed approach since the system was able to coordinate a fleet of robots in various different tests efficiently and safely, given the heterogeneity of the robots. This work is financed by the ERDF - European Regional Development Fund, through the Operational Programme for Competitiveness and Internationalisa tion - COMPETE 2020 Programme under the Portugal 2020 Partnership Agree ment, within project CrossLog, with reference POCI-01-0247-FEDER-039895 info:eu-repo/semantics/publishedVersion

In this paper, we present the results of a 6-year experiment in space that studied the effects of radiation in Gallium Nitride (GaN) electronics in geostationary orbit. Four GaN transistors in a Colpitts oscillator configuration were flown in the Component Technology Test-Bed aboard the Alphasat telecommunication satellite. A heuristic analysis was performed by observing the variation in the power output of the oscillators with the total ionizing dose gathered during the mission. The total ionizing dose was measured with a Radiation Sensing Field Effect Transistors (RadFET) placed close to the GaN devices. The experiment showed that GaN is a robust technology that can be used in the space radiation environment of a geostationary orbit. The work presented here starts with a brief introduction of the subject, the motivation, and the main goal. This is followed by the description of the experimental setup, including the details of the oscillator design and simulations, as well as the implementation of the test-bed and the Components Technology Test-Bed. Finally, the results obtained during the 6 years of experience in space are discussed.

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Most path planning algorithms used presently in multi-robot systems are based on offline planning. The Timed Enhanced A* (TEA*) algorithm gives the possibility of planning in real time, rather than planning in advance, by using a temporal estimation of the robot’s positions at any given time. In this article, the implementation of a control system for multi-robot applications that operate in environments where communication faults can occur and where entire sections of the environment may not have any connection to the communication network will be presented. This system uses the TEA* to plan multiple robot paths and a supervision system to control communications. The supervision system supervises the communication with the robots and checks whether the robot’s movements are synchronized. The implemented system allowed the creation and execution of paths for the robots that were both safe and kept the temporal efficiency of the TEA* algorithm. Using the Simtwo2020 simulation software, capable of simulating movement dynamics and the Lazarus development environment, it was possible to simulate the execution of several different missions by the implemented system and analyze their results. info:eu-repo/semantics/publishedVersion

Task Scheduling assumes an integral topic in the efficiency of multiple mobile robots systems and is a key part in most modern manufacturing systems. Advances in the field of combinatorial optimisation have allowed the implementation of algorithms capable of solving the different variants of the vehicle routing problem in relation to different objectives. However few of this approaches are capable of taking into account the nuances associated with the coordinated path planning in multi-AGV systems. This paper presents a new study about the implementation of the Simulated Annealing algorithm to minimise the time and distance cost of executing a tasks set while taking into account possible pathing conflicts that may occur during the execution of the referred tasks. This implementation uses an estimation of the planned paths for the robots, provided by the Time Enhanced A* (TEA*) to determine where possible pathing conflicts occur and uses the Simulated Annealing algorithm to optimise the attribution of tasks to each robot, in order to minimise the pathing conflicts. Results are presented that validate the efficiency of this algorithm and compare it to an approach that does not take into account the estimation of the robots paths. This work is financed by National Funds through the Portuguese funding agency, FCT - Fundação para a Ciência e a Tecnologia within project UIDB/50014/2020. info:eu-repo/semantics/publishedVersion

Automated guided vehicles (AGV) represent a key element in industries’ intralogistics and the use of AGV fleets bring multiple advantages. Nevertheless, coordinating a fleet of AGV is already a complex task but when exposed to delays in the trajectory and communication faults it can represent a threat, compromising the safety, productivity and efficiency of these systems. Concerning this matter, trajectory planning algorithms allied with supervisory systems have been studied and developed. This article aims to, based on work developed previously, implement and test a Multi AGV Supervisory System on real robots and analyse how the system responds to the dynamic of a real environment, analysing its intervention, what influences it and how the execution time is affected. This work is financed by National Funds through the Portuguese funding agency, FCT - Fundação para a Ciência e a Tecnologia within project UIDB/50014/2020. info:eu-repo/semantics/publishedVersion

Nesse artigo trazemos alguns termos e conceitos presentes na discussão do universo do trabalhador-estudante e suas especificidades, tendo como objetivo buscar discutir conceitos que nos auxiliam na compreensão da permanência, ou não, desses estudantes que trabalham no ambiente escolar. A discussão faz-se necessária quando percebemos, a partir de uma pesquisa, que os números da evasão se mostram expressivos em diversas instituições de ensino no Brasil. Todavia, o foco torna-se então, o estudante que se mantém estudando e trabalhando. Qual o contexto em que esse estudante está inserido, e o que o mantém na dupla jornada, quais suas dificuldades, essas e outras questões incitaram nossas reflexões e discussões. Como método, apresentamos e discutimos conceitos e termos de diversos autores, a partir de uma revisão bibliográfica, divididos em tópicos, como: evasão escolar; trabalho e educação, trabalhador-estudante e estudante-trabalhador; ensino noturno, formação de adultos, estratégias de permanência, sucesso e fracasso escolar, dentre outros. A relação entre trabalho e estudo é complexa e requer diversas analises a acerca desse fenômeno, tanto do ponto de vista dos indivíduos quanto das instituições envolvidas neste processo. Além dos fatores externos aos mesmos que interferem direta e indiretamente na trajetória de adultos que ocupam os bancos escolares do ensino noturno. Dessa forma, um dos resultados alcançados no desenvolvimento da pesquisa foi justamente contribuir para o campo teórico em que se insere, visto que são muitas dimensões sociais, educacionais, laborais e políticas que estão presentes na relação entre trabalho, estudos, instituições educacionais e estudantes.

A detecção de parasitas no sangue periférico é prova definitiva de infecção de Trypanosoma cruzi em vertebrados. O acompanhamento da parasitemia de T. cruzi em camundongos infectados é necessário tanto para a manutenção da cepa estudada em animais no laboratório, quanto para se inferir a modulação da infecção por diferentes tratamentos. A análise de amostras por esfregaço sanguíneo é utilizada para estudos morfométricos, mas apresenta baixa sensibilidade quando utilizada para parasitemia manual. É preferível que a contagem seja realizada de forma automatizada com máxima sensibilidade, em menor intervalo de tempo e com menores custos. Técnicas de processamento de imagens e reconhecimento de padrões já vêm sendo utilizadas em micrografias digitais com boa resolução para impressão, a partir de 300 ppp (pontos por polegada). Propomos a aplicação dessas técnicas em imagens com baixa densidade de pontos por polegada para parasitemia da cepa Y de T. cruzi, na forma tripomastigota. Analisamos microgafias de esfregaço sanguíneo coradas com Giemsa que foram obtidas com câmeras de dispositivos móveis. As câmeras desses aparelhos são capazes de capturar imagens com 72 ppp em uma área de 4000x3000 pixels, ou 12 megapixels. Realizamos a extração de um conjunto de descritores composto por medidas geométricas, de curvatura e de cor e textura do cinetoplasto e do núcleo de 2304 parasitos. Os descritores extraídos foram separados em conjuntos de treinamento e de teste e classificados com SVM. Os resultados de precisão, sensibilidade, especificidade e área ROC do método proposto foram de 91,4%, 91,7%, 97,9% e 94,5%, respectivamente. Nossos resultados demonstram que a automatização da análise de imagens com baixa densidade de ppp é uma alternativa viável para a redução de custos e ganho de eficiência na utilização do microscópio ótico. Detection of parasites in peripheral blood presents complete proof of Trypanosoma cruzi infection in vertebrates. Monitoring of T. cruzi parasitemia in infected mice is necessary for maintaining the strain studied in laboratory animals and for inferring the modulation of infection by different treatments. The analysis of blood smear samples is used for morphometric studies, but it presents low sensitivity when used for manual parasitemia. It is preferable to perform an automated couting with maximum sensitivity, in a shorter time, and with lower costs. Image processing and pattern recognition techniques have already been used in digital micrographs with good resolution for printing, from 300 dpi (dots per inch). We propose the application of these techniques in images with low density of dots per inch in the parasitemia of strain Y of T. cruzi, in trypomastigote form. We analyzed micrographs of blood smear stained with Giemsa obtained using mobile device cameras. Those cameras are capable of capturing images with 72 dpi in an area of 4000x3000 pixels, or 12 megapixels. We extracted a set of descriptors composed of geometric, curvature, color and texture measurements of the kinetoplast and nucleus of 2304 parasites. Those descriptors were divided into training and test sets and classified using SVM. The values of precision, sensitivity, specificity, and ROC area of the proposed method were 91.4%, 91.7, 97.9% and 94.5%, respectively. Automating image analysis with low dpi density is a viable alternative for reducing costs and gain efficiency in the use of the optical microscope.

Background The European Medicine Agency granted marketing approval to 164 orphan medicinal products for rare diseases, among which 28 products intended for the treatment of hereditary metabolic diseases. Taking advantage of its privileged connection with 69 healthcare centres of excellence in this field, MetabERN, the European Reference Network for hereditary metabolic diseases, performed a survey asking health care providers from 18 European countries whether these products are available on the market, reimbursed and therefore accessible for prescription, and actually delivered in their centre. Results Responses received from 52 centres (75%) concerned the design of treatment plans, the access to marketed products, and the barriers to delivery. Treatment options are always discussed with patients, who are often involved in their treatment plan. Most products (26/28) are available in most countries (15/18). Among the 15 broadly accessible products (88.5% of the centres), 9 are delivered to most patients (mean 70.1%), and the others to only few (16.5%). Among the 10 less accessible products (40.2% of the centres), 6 are delivered to many patients (66.7%), and 4 are rarely used (6.3%). Information was missing for 3 products. Delay between prescription and delivery is on average one month. Beside the lack of availability or accessibility, the most frequent reasons for not prescribing a treatment are patients’ clinical status, characteristic, and personal choice. Conclusions Data collected from health care providers in the MetabERN network indicate that two-third of the orphan medicines approved by EMA for the treatment of hereditary metabolic diseases are accessible to treating patients, although often less than one-half of the patients with the relevant conditions actually received the approved product to treat their disease. Thus, in spite of the remarkable achievement of many products, patients concerned by EMA-approved orphan medicinal products have persistent unmet needs, which deserve consideration. The enormous investments made by the companies to develop products, and the high financial burden for the Member States to purchase these products emphasize the importance of a scrupulous appreciation of treatment value involving all stakeholders at early stage of development, before marketing authorization, and during follow up.

Com o atual cenário de degradação ambiental se faz necessária uma Educação Ambiental (EA) preponderante, que auxilie no processo de transformação da sociedade, na sua maioria, alicerçada nos padrões de consumismo, distante dos preceitos de sustentabilidade. O presente artigo retrata a supervalorização que o ensino de EA tem posto na reciclagem com um sentido de customização, uma vez que a maior parte das atividades realizadas são voltadas para este viés, limitando-se a produção de materiais reutilizáveis, principalmente os objetos de decoração, havendo poucas reflexões sobre a necessidade de mudança de comportamento, além da falta de enfoque sobre a política dos 3R’s no cotidiano.

Objective: The authors present a case of obstructive sleep apnea associated with severe mandibular micrognathia treated by mandibular bone distraction with curvilinear system planned under computer assistance.Clinical Presentation: A 15-year-old child with limited compliance to continuous positive airway therapy was referred to the authors’ department. Observation revealed severe mandibular micrognathia as the major cause for obstructive sleep apnea syndrome. The first polysomnography study revealed 14 obstructive apneas, 16 obstructive hypopneas, and 4.6/h apnea-hypopnea index.Conclusion: Mandibular distraction osteogenesis can be a successful technique in alleviating upper airway obstruction secondary to micrognathia, while also improving the patient’s appearance. Surgical planning under computer assistance is a useful tool to predict bone movements, and curvilinear distraction could be considered valuable in mandibular distraction.

Purpose: As football is a connection/loyalty-based sport, this study aimed to investigate the effects that a simultaneous sponsorship of two rival clubs has on the sponsor itself, as well as understand the reaction that team supporters display toward that situation. Another aim was to examine the existence of congruency of attributes between the sponsor brand and either of the clubs, in addition to understanding the effects of exposure on attitudes towards the sponsor and on purchase intentions, towards sponsor. Methodology: First a literature review was conducted on the topics of sports sponsorship, brands, congruency, attitude towards sponsor and purchase intentions. Next, hypotheses were formulated and tested through an online survey applied midst sports enthusiasts. Lastly, the data was analysed and the hypotheses were verified. Findings: This study uncovered that different types of exposure and level of involvement translate into different levels of awareness; awareness takes a positive effect on attitude towards sponsor and, the latter on purchase intentions. Additionally, it was demonstrated that a brand sponsoring two rival clubs does not affect both sets of fans in the same regard (when having into account the set of attitudes and the awareness) (based on the articulation of values and traits), hence, exhibiting the importance of congruent communication. Contributions: This study adds to previous research by encompassing the study of the effects of a simultaneous sponsorship of two rival clubs in a different cultural setting. Furthermore, this study considered the different level of exposition of a sponsor and its effects. Objetivo: Sendo o futebol um desporto baseado na lealdade, este estudo pretendeu investigar os efeitos que se verificam num patrocínio simultâneo a dois clubes rivais, bem como, perceber a reação dos apoiantes dos clubes. Outro intuito foi o de examinar a existência de congruência dos atributos entre o patrocinador e os clubes, além de entender os efeitos do nível de exposição nas atitudes dos adeptos e nas intenções de compra, face ao patrocinador. Metodologia: Primeiramente foi realizada uma revisão de literatura sobre os temas marketing no desporto, marcas (valores, imagem, consciência), congruência, atitudes e intenções de compra em relação a um patrocinador. Seguidamente, foram formuladas hipóteses posteriormente testadas através de um questionário aplicado online junto de adeptos. Por último, foram analisados os dados e verificadas as hipóteses. Resultados: Este estudo revelou que diferentes tipos de exposição e nível de envolvimento se traduzem em diferentes níveis de conhecimento do patrocínio; que por sua vez, tem um efeito positivo na atitude face ao patrocinador e, este último nas intenções de compra. Adicionalmente, foi demonstrado que uma marca que patrocine dois clubes rivais não afeta ambos os grupos de adeptos de forma semelhante (quando consideradas as atitudes e o conhecimento/reconhecimento) (com base na harmonização/enquadramento de valores), evidenciando a importância de comunicação congruente. Contribuições: Esta dissertação contribui para estudos anteriores por considerar o estudo dos efeitos de um patrocínio simultâneo a clubes rivais num contexto cultural diferente. Adicionalmente, este estudo considerou os diferentes níveis de exposição de um patrocínio e os seus efeitos.

Background MetabERN is one of the 24 European Reference Networks created according to the European Union directive 2011/24/EU on patient’s rights in cross border healthcare. MetabERN associates 69 centres in 18 countries, which provide care for patients with Hereditary Metabolic Diseases, and have the mission to reinforce research and provide training for health professionals in this field. MetabERN performed a survey in December 2017 with the aim to produce an overview documenting research activities and potentials within the network. As the centres are multidisciplinary, separated questionnaires were sent to the clinical, university and laboratory teams. Answers were received from 52 out of the 69 centres of the network, covering 16 countries. A descriptive analysis of the information collected is presented. Results The answers indicate a marked interest of the respondents for research, who expressed high motivation and commitment, and estimated that the conditions to do research in their institution were mostly satisfactory. They are active in research, which according to several indicators, is competitive and satisfies standards of excellence, as well as the education programs offered in the respondent’s universities. Research in the centres is primarily performed in genetics, pathophysiology, and epidemiology, and focuses on issues related to diagnosis. Few respondents declared having activity in human and social sciences, including research on patient’s quality of life, patient’s awareness, or methods for social support. Infrastructures offering services for medical research were rarely known and used by respondents, including national and international biobanking platforms. In contrast, respondents often participate to patient registries, even beyond their specific field of interest. Conclusions Taken as a whole, these results provide an encouraging picture of the research capacities and activities in the MetabERN network, which, with respect to the number and representativeness of the investigated centres, gives a comprehensive picture of research on Hereditary Metabolic Diseases in Europe, as well as the priorities for future actions. Marginal activity in human and social sciences points out the limited multidisciplinary constitution of the responding teams with possible consequences on their current capability to participate to patient’s empowerment programs and efficiently collaborate with patient’s advocacy groups. Electronic supplementary material The online version of this article (10.1186/s13023-019-1091-8) contains supplementary material, which is available to authorized users.

A cidade do Porto tem-se apresentado, ultimamente, como um dos destinos mais representativos de Portugal, devido ao seu potencial turístico e à sua diversidade. Sendo assim, esta pesquisa apresenta uma análise dos agentes da oferta turística na cidade do Porto e das estratégias de marketing utilizadas para potenciar a recetividade do destino, além de dar a conhecer o nível de satisfação dos indivíduos que visitam estes espaços, em função da oferta disponibilizada, desde alojamento, saunas, festas e eventos, bares e clubes noturnos e também circuitos LGBTQI+. O objetivo deste artigo é apresentar contributos acerca da mensuração da cidade do Porto enquanto destino LGBTQI+, através de dois tipos de análise, uma qualitativa e a outra quantitativa. A análise qualitativa, que se efetuou através de entrevistas, incidiu sobre os agentes comerciais, que foram questionados sobre a existência de marketing dirigido a este segmento onde se percebe a existência do marketing e como são praticadas as ações. Quanto à análise quantitativa, dirigida tanto à comunidade local como à visitante LGBTQI+, foram analisadas as perceções da oferta turística da cidade do Porto e as opiniões/recomendações acerca do impulsionamento do destino Porto enquanto destino LGBTQI+. Por fim, e no que diz respeito aos resultados, pode concluir-se que a cidade do Porto ainda não é um destino LGBTQI+ consolidado, apesar da diversidade na oferta., Revista Turismo & Desenvolvimento, n.º 32 (2019)

Background: Leishmaniasis is an infectious disease caused by Leishmania parasites. A Th1 immune response is necessary in the acute phase to control the pathogen. The triggering receptor expressed on myeloid cells (TREM)-1 is a potent amplifier of inflammation. Our aim is to identify whether the TREM1 variant rs2234237 A/T (Thr25Ser) is associated with the disease development of cutaneous leishmaniasis (CL) in Leishmania guyanensis-infected individuals. The effects of the rs2234237 genotypes on plasma cytokines IL-1β, IL-6, IL-8, IL-10, MCP-1 and TNF-α are also investigated. Methods: 838 patients with CL and 818 healthy controls (HCs) living in the same endemic areas were genotyped by Polymerase Chain Reaction-Restriction Fragment Length Polymorphism. Plasma cytokines were assayed in 400 patients with CL and 400 HCs using the BioPlex assay. Results: The genotypes’ and alleles’ frequencies were similar in both patients with CL (AA = 618, 74%, AT = 202, 24%, TT = 18, 2%) and in HCs (AA = 580, 71%, AT = 220, 27%, TT = 18, 2%). Rs2234237 showed a modest effect on plasma IL-10 that disappeared when correction of the p-value was applied. Plasma IL-10 by rs2234237 genotypes were (mean ± SEM, AA = 2.91 pg/mL ± 0.14, AT = 2.35 pg/mL ± 0.12, TT = 3.14 pg/mL ± 0.56, p = 0.05). Conclusion: The TREM1 rs2234237 (Thr25Ser) seems to have no influence on the susceptibility or resistance to L. guyanensis infections.

Introdução: O fibroxantoma atípico (FXA) é um tumor raro de histogénese indeterminada mais frequente em idosos nas áreas fotoexpostas da cabeça e pescoço. Trata-se de um tumor indiferenciado sendo o seu diagnóstico histológico de exclusão. Apesar de classicamente indolente, os casos descritos associados a metastização atribuem-lhe uma malignidade intermédia.Material e métodos: Foi objetivo deste estudo retrospetivo rever e caracterizar os casos de FXA diagnosticados no nosso serviço entre 2008 e 2014. Foram avaliadas variáveis demográficas, clínicas, dados histológicos, imunohistoquímicos, terapêutica cirúrgica e recidiva.Resultados: Foram diagnosticados 12 casos de FXA, 11 do sexo masculino e 1 do sexo feminino, o mais novo com 25 anos e os restantes com idade média de 76 anos. Apresentaram-se como nódulos/tumores com diâmetro médio de 1,9cm, todos localizados na cabeça. Histologicamente revelaram-se lesões bem delimitadas com grande atipia citológica e elastose solar frequente, todas classificadas na variante mista (células fusiformes e histiocitárias). Na imunohistoquímica verificou-se positividade para a vimentina e negatividade para as citoqueratinas e proteína S100 em todos os casos, sendo positivos o CD10 e CD99 na maioria dos casos. A terapêutica foi cirúrgica com excisão radical da lesão em 10 doentes, sendo a recidiva local de 10% num seguimento médio de 3 anos.Conclusões: Os resultados obtidos foram concordantes com outras séries da literatura. Dada a clínica inespecífica e tratando-se de um tumor histologicamente indiferenciado a imunohistoquímica é essencial, não existindo ainda marcadores suficientemente específicos. Apesar do bom prognóstico na maioria dos casos a vigilância destes doentes é recomendada.

O carcinoma ductal écrino é uma neoplasia cutânea rara com curso clínico agressivo. O seu diagnóstico implica a exclusão dum adenocarcinoma primário noutra localização com metastização cutânea, já que os dados histológicos e imunohistoquímicos por si sós não o permitem. Reporta-se o caso clínico de um homem de 75 anos com um tumor de 3cm localizado na hemiface direita, o qual foi excisado e cujo exame histológico e imunohistoquímico apontavam para o diagnóstico de um carcinoma ductal écrino. A investigação complementar mostrou múltiplos nódulos pulmonares e pleurais, bem como envolvimento neoplásico da coluna vertebral dorsal e lombar. O exame histológico e imunohistoquímico destes achados, complementado com a ausência de achados imagiológicos sugestivos de uma neoplasia primária noutro local, permitiram o diagnóstico de um carcinoma ductal écrino metastizado. O doente morreu 6 meses após a primeira observação.

O vírus herpes simplex é o principal responsável por ulcerações genitais de etiologia infecciosa. No contexto de imunodeficiência, manifesta-se frequentemente de forma atípica, com lesões mais floridas, sendo também frequente a resistência à terapêutica clássica, resultando numa evolução prolongada.Descreve-se o caso clinico de um homem de 25 anos, com antecedentes de imunodeficiência comum variável, que recorre à nossa consulta por ulcerações genitais extensas e exuberantes da região inguino-escrotal de etiologia herpética. Após terapêutica prolongada com valaciclovir, o doente mantinha-se sintomático, tendo-se optado pela associação de imiquimod 5% tópico, com resolução do quadro clínico e excelente tolerância.O imiquimod, funcionando como um imunomodulador local, estimula a resposta imunológica antiviral. Configura- -se assim como uma alternativa nos casos de infeções herpéticas de difícil controlo, especialmente em doentes imunodeprimidos.

The forth industrial revolution is here, and with it Industry 4.0, which translates in many changes to the industry. With the introduction of paradigms like Internet of Things, Cyber Physical Systems or Cloud Computing, the so called Smart Factories are becoming a main part of today’s manufacturing systems. The vf-OS Project, where this thesis falls, intends to be an Open Operating System for Virtual Factories where the overall network of a collaborative manufacturing and logistics environment can be managed and thus enabling humans, applications and devices to communicate and interoperate in an interconnected operative environment. This thesis intends to contribute to the vision that any kind of sensor or actuator plugged to the virtual factory network, becomes promptly accessible in the operative environment and the services that it provides can be accessed and used by any API composing the system. Finally, it also aims to prove that an IoT Service Oriented Sys-tem constituted of open software components can be of great assistance and provide numerous contributions to the emerging Industry 4.0 and consequently to the Factories of the Future. With that aim, this thesis will focus on the development of two out of five inter-connected applications that answer not only to different use case scenarios presented in the vf-OS but also provide solutions to answer a practical agriculture scenario, which uses mainly IoT devices and other cutting-edge technologies like cloud compu-ting and FIWARE.

Os museus integram o sistema de produção e difusão cultural de uma determinada região e são importantes coadjuvantes no processo de formação e educação da sociedade. O Museu da Gente Sergipana é considerado um dos museus mais modernos do país, pelo fato da tecnologia de ponta que emprega. Pretende-se, por meio deste artigo, desenvolver pesquisa de campo para reconhecer as relações entre cultura e economia, em especial o papel do Museu da Gente Sergipana localizado em Aracaju. O artigo está, portanto, dividido em quatro seções, incluindo a introdução. Os resultados aqui encontrados evidenciam o papel relevante do Museu da Gente Sergipana na cena cultural de Aracaju, mas mostram, por outro lado, que o processo de fidelização e identidade do residente com o espaço é algo ainda em processo de construção, que depende, em muito, das ações educativas para formação de público The museums are part of the system of cultural production and dissemination of a particular region and are important adjuncts in the process of training and education of society. The Museum of People Sergipana is considered one of the most modern museums in the country, because of the latest technology it employs. It is intended, through this article, develop field research to recognize the relationship between culture and economy, in particular the role of Museum of People Sergipana located in Aracaju. The article is therefore divided into four sections, including the introduction. The present results show the important role of the Museum of People Sergipana in the cultural scene of Aracaju but show, however, that the process of loyalty and identity of the resident with the space is something still under construction, which highly depends on, educational activities for public education

Motivation Information about metabolic pathways in a comparative context is one of the most powerful tool to help the understanding of genome-based differences in phenotypes among organisms. Although several platforms exist that provide a wealth of information on metabolic pathways of diverse organisms, the comparison among organisms using metabolic pathways is still a difficult task. Results We present TabPath (Tables for Metabolic Pathway), a web-based tool to facilitate comparison of metabolic pathways in genomes based on KEGG. From a selection of pathways and genomes of interest on the menu, TabPath generates user-friendly tables that facilitate analysis of variations in metabolism among the selected organisms. Availability and implementation TabPath is available at http://200.239.132.160:8686.