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Typhoons are among the most significant natural disasters affecting the eastern and southern coastal regions of China, inflicting substantial annual damage on both coastal and inland areas. Since the initiation of the reform and opening-up policy, the socioeconomic development of the coastal regions of China has been swift, leading to increased exposure to typhoons. In the context of global climate change, typhoons are expected to increase in frequency and intensity in China. Therefore, researching on the spatiotemporal pattern characteristics of typhoons impacting China is of critical importance for understanding the impact patterns and risk changes of typhoon disasters, as well as for formulating policies on disaster response, prevention, and mitigation. This study aims to provide valuable insights into the formulation of such policies. Based on these objectives, this study utilized a comprehensive dataset, including county-level socioeconomic and disaster statistics, historical typhoon wind and rainfall data, and high-precision topographic data. Using county-level administrative regions as spatial units, this study employed various methods, such as time-series statistical analysis, gravity model, geographical detector, spatial correlation analysis, and geographically weighted regression, to analyze the spatiotemporal distribution patterns and influencing factors of typhoon disaster conditions in China from 1978 to 2020. The findings of this study are as follows: (1) The number of deaths and missing persons, quantity of damaged housing, death, and missing rate per million people, and proportion of direct economic loss to GDP caused by typhoon disasters have all shown a declining trend, indicating significant achievements in disaster prevention and mitigation efforts. (2) The center of gravity of typhoon disaster-related losses has shifted southward, corresponding with the economic development of coastal regions, demonstrating a reduced disaster impact in coastal areas and an increased impact in inland areas. (3) Wind and rain induced by typhoons are the primary driving factors of disaster conditions, and topographical factors are also drivers of casualties and crop loss. (4) The two major regions, Zhejiang-Northern Fujian and Western Guangdong-Eastern Guangxi, exhibit significant characteristics of disaster condition agglomeration, closely related to typhoon activity patterns and levels of economic development. (5) There is a negative correlation between the gross local product and disaster conditions in some areas, reflecting the role of socioeconomic development in enhancing the capacity for disaster prevention and mitigation.

Objective Meta-analysis was used to compare the efficacy of unilateral biportal endoscopy (UBE) and unilateral endoscopy(UE) in the treatment of lumbar degenerative diseases (LDD), in order to provide a reference for clinical treatment selection. Methods By searching the literature on UBE or UE treatment of LDD in PubMed, Web of Science, Wanfang database, CNKI and other databases, with searching date from March 2019 to November 2023. The quality of the collected literature was evaluated and the relevant outcome data were extracted, then Meta-analysis was conducted. The outcome indicators included: operative time, intraoperative blood loss, postoperative hospital stay, complication rate, number of intraoperative fluoroscopies, modified MacNab grading scale, visual analogue scale (VAS) for low back pain or leg pain, and Oswestry disability index (ODI). Results Sixteen papers (including 2 randomized controlled studies, 14 non-randomized controlled studies) with a total of 1 398 patients (including 709 patients treated with UBE , 689 patients treated with UE) were finally enrolled. The results of the Meta-analysis:compared with UE, the number of intraoperative fluoroscopy was higher in UBE ［MD=0.16,95%CI(0.05,0.26),P=0.004］; the VAS score of back and leg pain and ODI in the early postoperative period were better［MD=-0.20,95%CI(-0.34,-0.07),P=0.004; MD=-0.17,95%CI(-0.33,-0.01),P=0.03;MD=-0.72,95%CI(-1.36,-0.08),P=0.03］. Subgroup analysis: for LSS,the operation time of UBE was shorter than that of UE［MD=-10.28,95%CI(-16.74,-3.82),P＜0.01;the VAS score of postoperative back pain was better［MD=-0.22,95%CI(-0.42,-0.01),P=0.04］. For LDH,the operation time of UBE was longer than that of UE［MD=14.45,95%CI(4.07,24.84),P

Objective: To determine the inhibitory effects of pachymic acid on lung adenocarcinoma (LUAD) cells and elucidate its underlying mechanism. Methods: CCK-8, wound healing, Transwell, Western blot, tube formation, and immunofluorescence assays were carried out to measure the effects of various concentrations of pachymic acid on LUAD cell proliferation, metastasis, angiogenesis as well as autophagy. Subsequently, molecular docking technology was used to detect the potential targeted binding association between pachymic acid and protein tyrosine phosphatase 1B (PTP1B). Moreover, PTP1B was overexpressed in A549 cells to detect the specific mechanisms of pachymic acid. Results: Pachymic acid suppressed LUAD cell viability, metastasis as well as angiogenesis while inducing cell autophagy. It also targeted PTP1B and lowered PTP1B expression. However, PTP1B overexpression reversed the effects of pachymic acid on metastasis, angiogenesis, and autophagy as well as the expression of Wnt3a and β-catenin in LUAD cells. Conclusions: Pachymic acid inhibits metastasis and angiogenesis, and promotes autophagy in LUAD cells by modulating the Wnt/β-catenin signaling pathway via targeting PTP1B.

Abstract This study aimed to examine the role played by the physical literacy and mindfulness in the health-related quality of life (QoL) of college students. In early 2022, 24,236 college students from three universities in southern China were recruited in the study. R software and the lavvan package was utilized to build the structural equation model. The measurement model was composed of three latent factors (physical literacy, mindfulness, and quality of life) and 16 observed variables in total. The results of the measurement model indicated goodness fit with p > .05 in Chi-square result, and GFI = .92. In addition, the comparative fit index (.92), Tucker–Lewis index (.91), root-mean-square error of approximation (.07), and root of mean square residual (.11) were in accord with the cutoff model-fit criteria. The results confirm that physical literacy and mindfulness can play a significant and positive role in the structural equation model of quality of life. In addition, this study provides initial evidence that mindfulness and physical literacy could potentially buffer declines in student QoL during the COVID-19 pandemic. Moreover, this study is the first to develop a structural equation model of QoL with multiple indicators, making it a strong addition to existing research on QoL during a pandemic.

Objective To improve the accuracy of rational diet and the quality of life in hospitalized patients with diabetes mellitus by using quality control circle activities. Methods The problem-solving QCC activities were carried out, and the corresponding countermeasures were formulated and implemented, including the establishment of a systematic health education model, the establishment of a multi-dimensional training system, and establishment of a perfect catering mechanism in the canteen. Results The accurate rate of rational diet in hospitalized diabetic patients increased from 45. 52% before implementation of QCC activities to 77. 99% after implementation of QCC activities. Conclusion The QCC activities can improve the accurate rate of rational diet for hospitalized patients with diabetes mellitus, effectively improve the blood sugar level, improve the self-management ability, delay disease progression, and improve the quality of life. (目的 探讨品管圈活动提高住院糖尿病患者合理膳食精准率的效果, 旨在改善患者生活质量。方法 开展问题解决型品管圈活动, 通过现状分析、原因解析, 制定针对性对策并实施, 包括构建系统化健康教育模式、建立多维度培训体系、建立完善的食堂配餐机制等。结果 住院糖尿病患者合理膳食精准率从品管圈活动实施前的45. 52%提升至品管圈活动实施后的77. 99%。结论 通过品管圈活动, 能提高住院糖尿病患者合理膳食精准率, 有助于改善住院糖尿病患者的血糖水平, 提高患者自我管理能力, 延缓疾病进展, 提高生活质量。)

We evaluated the expression profiles of differentially expressed miRNAs (DEmiRNAs) involved in human fetal skin development via high-throughput sequencing to explore the expression difference and the regulatory role of miRNA in different stages of fetal skin development. Analysis of expression profiles of miRNAs involved collecting embryo samples via high-throughput sequencing, then bioinformatics analyses were performed to validate DEmiRNAs. A total of 363 miRNAs were differentially expressed during the early and mid-pregnancy of development, and upregulated DEmiRNAs were mainly concentrated in the let-7 family. The transfection of let-7b-5p slowed down HaCaT cell proliferation and promoted apoptosis, as evidenced by the cell counting kit-8 assay, quantitative real-time polymerase chain reaction, and flow cytometry. The double luciferin reporter assay also confirmed let-7b-5p and ΔNp63 downregulation through the combination with the 3ʹ-untranslated region of ΔNp63. Moreover, treatment with a let-7b-5p inhibitor upregulated ΔNp63 and activated the phosphoinositide 3-kinase (PI3K)-protein kinase B (AKT) signaling pathway. The let-7b-5p caused a converse effect on HaCaT cells because of Np63 upregulation. Let-7b-5p regulates skin development by targeting ΔNp63 via PI3K-AKT signaling, contributing to future studies on skin development and clinical scar-free healing.

The high temperature oxidation behavior of NbMoTaWV refractory high entropy alloy(RHEA) prepared by arc melting was studied by static oxidation experiment, XRD and FSEM. The results reveal that the NbMoTaWV RHEA is not protective due to severe cracks in the oxide layer at 1000 ℃ and 1200 ℃. The mass gain follows a linear oxidation law. Molten oxides formed at 1400 ℃, which release the growth stress of the oxide layer and fill the holes left by the volatilization of Mo and V oxides.In the oxidation process of NbMoTaWV, oxygen diffuses into the matrix and first oxidizes with Nb and Ta in the diffusion layer to generate needle-rod like oxidation products, and then oxidizes with other alloy elements. In the subsequent oxidation process, the oxides of W are dissolved in Nb and Ta oxides, while the granular mixed oxides of Mo and V volatilize at high temperatures.

This article explores how digital technologies such as big data and cloud computing promote college students’ innovation and entrepreneurship, especially the impact of innovation and entrepreneurship training programs on college students’ entrepreneurial intentions. The article adopts big data analysis techniques to screen variables, set research hypotheses, and use partial least squares regression to quantitatively analyze the correlation between university innovativeness and training programs. It was found that the number of university intellectual property rights was significantly associated with the objectives of the training program, with a regression coefficient of 0.069. Further, the article pointed out that most students believed that the regulation of the research segment was the weakest. Therefore, the article suggests improving the training program supervision system, significantly strengthening the supervision of the research session, and also explores the correlation between academic professional factors and faculty guidance.

To obtain the influence of anisotropy and energy evolution characteristics on wellbore stability, the acoustic and mechanical anisotropy characteristics of shales are studied through various experiments, including scanning electron microscopy, ultrasonic pulse transmission, and uniaxial compression experiments, with the Longmaxi Formation shale in the southern area of the Sichuan Basin as the research object. The energy evolution characteristics of the Longmaxi Formation shale under different bedding angles are analyzed. The influence of anisotropy on the wellbore stability of shale formation is discussed on this basis. The results show that the acoustic and mechanical parameters, failure mode, and energy evolution characteristics of shale have significant anisotropy. Furthermore, the P-wave and S-wave time differences decrease with an increase in bedding angle. The compressive strength and Poisson’s ratio decrease first and then increase with an increase in bedding angle. Meanwhile, the elastic modulus gradually increases with an increase in bedding angle. Rock samples with different bedding angles show diverse failure modes in mechanical tests, including splitting, shear, and shear-splitting failure. The total energy and elastic energy decrease first and then increase with an increase in bedding angle. Finally, the formation anisotropy affects the wellbore stability: the higher the formation anisotropy, the more vulnerable is the wellbore to instability.

This study was devoted to demonstrating the role of IL-31 and IL-34 in the diagnosis and treatment of chronic periodontitis (CP). From the results, we found that the IL-31 and IL-34 levels were significantly increased in GCF and serum of CP patients compared with healthy controls or obese patients. Meanwhile, the area under the curve results further verified the diagnostic potential of IL-31 and IL-34 in terms of discriminating CP from obese patients at the GCF and serum levels. Finally, after 1 year of continuous treatment, we found that IL-31 and IL-34 levels were decreased in CP, suggesting their potential as biomarkers in CP treatment response. Monitoring GCF and serum levels of IL-31 and IL-34 contributed to CP detection and treatment response.

Gingival pigmentation is a nonplaque gum disease. Patients are often afraid to communicate with others because of gum color problems, which affect the social and mental health of patients. The commonly used treatment methods for gingival pigmentation include scalpel excision, gingival grinding, laser therapy, cryosurgery and electrosurgery. In this paper, the progress of gingival pigmentation treatment was reviewed in terms of bleeding, pain, tissue healing and recoloring. The results showed that the clinical effect of laser treatment was better. Among them, the semiconductor laser had more advantages in reducing bleeding, pain and the restaining rate, while the Er:Cr:YSSG/Er:YAG laser performed better for promoting tissue healing. Clinicians can choose the best kind of laser to use according to the actual situation. For patients with thin gingival biotypes, floating gingival transplantation or substitute materials can be selected to restore the gingival morphology. With the in-depth study of melanin regulation mechanisms, various drugs, such as ascorbic acid, natural peptides, synthetic peptides and derivatives, may be the main research direction for the treatment of gingival pigmentation in the future.

Leakage occurred on a company′s waste heat recovery unit after short-term operation of it. In order to determine the cause of the leak and take effective countermeasures, the reasons for the failure of the waste heat recovery device were analyzed. Firstly, the stress level of the waste heat recovery device under working condition was calculated by Ansys simulation software, and the maximum stress point was found at the tube sheet, and the stress value at the joint of tube sheet and heat exchange tube was larger.Then, macro-corrosion morphology analysis, metallographic microstructure analysis, micro-hardness test, scanning electron microscope（SEM） analysis of corrosion micro-morphology and EDS micro-area composition analysis of corrosion products were carried out on the sampling site of tube bundle leakage.The results show that, because of high temperature, increasing alkali concentration occurs at the crack of tube bundle. And welding cracks exist there, which eventually leads to alkali stress corrosion cracking at the weld of tube sheet and tube bundle.

In order to verify the effect of the new fully biodegradable external dressing on the repair of diabetes skin wounds and the promotion of wound healing, this study applied sodium alginate hydrogel dressing products which are supplemented with phage and conotoxin analgesic peptides to the skin lesions of diabetes mice, and comprehensively used the quantitative measurement of serological indicators, Image J Tissue section and other techniques to evaluate the effect of the new hydrogel dressing on the repair of diabetes wounds and the promotion of wound healing. The behavioral observation and analysis of mice did not show obvious regularity and difference. According to the results of serum cytokine analysis, functional hydrogel dressings can promote cell regeneration and wound healing in mice. Image J software analysis showed that the healing results of the experimental group were better than those of the negative control group, and the percentage of collagen fiber content showed an upward trend. Through comprehensive evaluation, it can be observed that the new fully biodegradable external dressing has obvious positive effects on wound healing, collagen fiber reconstruction and wound infection prevention of diabetes. The new biodegradable dressing not only promotes wound healing but also solves environmental pollution problems. It meets the sustainable development needs of society and has broad application prospects.

ObjectiveTo establish a detection method for thiourea in wheat flour and flour treatment agents（FTA） by pass-through solid phase extraction purification and high performance liquid chromatography.MethodsThe samples were extracted by acetonitrile aqueous solution（8：2， V/V）， and purified by PRiME HLB pass-through SPE column. The extract was separated on a XBridge Amide column （4.6 mm×250 mm， 5 μm） with acetonitrile and water as the mobile phase in gradient elution， and detected by high performance liquid chromatography-diode array detector （HPLC-DAD）.ResultsThe linear correlation coefficient （R2） was higher than 0. 9999 in the range of 0.05-20 μg/mL. The limit of detection （LOD） and the limit of quantification （LOQ） were 0.15 and 0.5 mg/kg， respectively. The average recoveries ranged from 95.5% to 103.7% with the relative standard deviation （RSD） less than 5.7% at three spiked levels of LOQ， 2LOQ and 10LOQ.ConclusionThe problem of easy gelation and poor dispersion effect of FTA had been solved by the method established in this experiment， while matrix interference in wheat flour and FTA reduced effectively， which protected the chromatographic column. This simple， sensitive， accurate method is suitable for the confirmation and quantification of thiourea in wheat flour and FTA.

Objective: To study the effect of food preservatives on the freshness of pre-conditioned pork filling stuffing and to solve the problem of easy spoilage and very short shelf life of pre-conditioned pork filling stuffing. Methods: The changes of physicochemical and microbiological indexes of the pre-conditioned pork filling treated with vacuum-packed co-combination preservatives during storage were determined using the total number of colonies or TBA values as evaluation criteria. Results: The optimal ratio of preservatives were as followed: 0.049% nisin, 0.207% D-isoascorbate sodium, 0.029% rosemary extract. Vacuum-packed synergistic compounding preservative treatment can effectively delay the changes of total bacterial colony, TBA value, TVB-N value, pH value, and has better sensory score, and its shelf life can reach 10 days. Conclusion: Vacuum packaging synergistic compounding preservative treatment of pre-conditioned pork filling has a better preservation effect and can effectively extend its shelf life.

Airway remodeling is a remarkable pathological characteristic of chronic obstructive pulmonary disease (COPD), and long noncoding RNAs have been demonstrated to participate in COPD development and pathogenesis. Here, we investigate the role of long noncoding RNA GAS5 in cigarette smoke (CS)-induced airway remodeling. GAS5 expression is significantly lower in lung tissues of CS-exposed mice than in tissues of control mice without exposure to CS. Forced GAS5 overexpression suppresses CS-induced airway inflammation and remodeling. GAS5 overexpression also inhibits CS extract-induced inflammatory-cytokine expression and fibroblast activation in vitro. Regarding the mechanism, GAS5 acts as a sponge of miR-217-5p, thereby increasing PTEN expression. MiR-217-5p overexpression and PTEN knockdown separately reverse the inhibitory effects of GAS5 overexpression on the inflammatory-cytokine expression and fibroblast activation. Collectively, these results suggest that GAS5 can suppress airway inflammation and fibroblast activation by regulating miR-217-5p/PTEN axis, which may help develop novel therapeutic strategies against COPD.

With the ubiquitous use of global navigation satellite system (GNSS) receivers, navigation solutions from smartphones have become integrated in various applications throughout our lives. These ultra-low-cost GNSS receivers have the drawbacks of insufficient observations and poorer signal reception quality than higher-cost receivers. Since 2016, smartphones using the Android operating system have been able to output raw GNSS pseudorange and carrier-phase measurements, thereby enabling improved navigation capabilities. The realm of sensor fusion is also being explored by using smartphone sensors, including inertial measurement units (IMUs), cameras, and other fusion techniques. The research presented herein deployed only IMU and GNSS sensors native to existing smartphones and achieved a standalone solution using PPP/IMU integration that outperformed standard techniques. In open-sky vehicle experiments, the sensor integration algorithm achieved 1.6-m horizontal RMS, thus reducing 80% of horizontal errors in GNSS-challenging environments through a tightly coupled GNSS-PPP solution that is yet to appear in publications.

Deep learning approaches have demonstrated great achievements in the field of computer-aided medical image analysis, improving the precision of diagnosis across a range of medical disorders. These developments have not, however, been immune to the appearance of adversarial attacks, creating the possibility of incorrect diagnosis with substantial clinical implications. Concurrently, the field has seen notable advancements in defending against such targeted adversary intrusions in deep medical diagnostic systems. In the context of medical image analysis, this article provides a comprehensive survey of current advancements in adversarial attacks and their accompanying defensive strategies. In addition, a comprehensive conceptual analysis is presented, including several adversarial attacks and defensive strategies designed for the interpretation of medical images. This survey, which draws on qualitative and quantitative findings, concludes with a thorough discussion of the problems with adversarial attack and defensive mechanisms that are unique to medical image analysis systems, opening up new directions for future research. We identified that the main problems with adversarial attack and defense in medical imaging include dataset and labeling, computational resources, robustness against target attacks, evaluation of transferability and adaptability, interpretability and explainability, real-time detection and response, and adversarial attacks in multi-modal fusion. The area of medical imaging adversarial attack and defensive mechanisms might move toward more secure, dependable, and therapeutically useful deep learning systems by filling in these research gaps and following these future objectives.

In order to solve the problem of capacity reduction of Schiff base monomer in lithium-ion batteries due to the dissolution of active substances, the Schiff base polymer(PI) with C=N bond was prepared by one-step condensation method using p-benzaldehyde and p-phenylenediamine as raw materials. Poly(Schiff base)/carbon nanotubes(PI/CNTs) composites with high conductivity were prepared by doping carbon nanotubes(CNTs). The composition, structure, micro morphology and electrochemical properties of the prepared materials were analyzed by using FT-IR, SEM, XRD, TG, XPS and electrochemical workstation. The results indicate that the PI/CNT material with 5%CNTs(mass fraction) is a three-dimensional frame structure, and shows excellent electrochemical performance. The first specific capacity of PI/CNT-3 material is 209.9 mAh·g-1. After 200 cycles, the cycle retention rate is 60.5%. When the rate of charge and discharge is 0.1 C, 0.2 C, 0.5 C, 1 C and 0.1 C, the specific capacity of PI/CNT-3 electrode materials is 182.4, 150.8, 129.8, 101.3 mAh·g-1 and 156.4 mAh·g-1 respectively, which has good cycle stability and rate performance.

Objective The purpose of this study was to investigate the effect of different concentrations of exosomes (Exos) secreted from dental folic cells (DFCs) preconditioned with lipopolysaccharide (LPS) on the osteogenic differentiation ability of periodontal cells in periodontitis (p-PDLCs) in patients to provide a basis for the prevention and treatment of periodontal disease. Method Tissue block and enzyme digestion methods were used to culture DFCs and p-PDLCs. Exosomes were isolated from 250 ng/mL LPS-preconditioned DFCs 24 h later. The characteristics of exosomes were detected by transmission electron microscopy, particle size analysis and Western blotting. The effects of 10 μg/mL and 100 μg/mL exosomes on the osteogenic differentiation of p-PDLCs were detected by RT-PCR and Alizarin red staining. Results LPS-pretreated DFC-derived exosomes (L-Exos) are vesicle-like structures with a size between 30-100 nm that positively express CD63 and Alix. Compared with the control group, exosomes significantly upregulated Periostin, Col Ⅰ, and Col Ⅲ expression at 100 μg/mL (P < 0.05), while TGF- β1 was significantly upregulated at 10 μg/mL (P < 0.01). At 7 days after osteogenic induction, mineralized nodules were significantly more abundant in the exosome group than in the control group (P < 0.01), and the results were better at a concentration of 100 μg/mL (P < 0.01). Conclusion 100 μg/mL L-Exos are better than 10 μg/mL L-Exos in enhancing the osteogenic differentiation ability of p-PDLCs.

Precise positioning using smartphones has been a topic of interest especially after Google decided to provide raw GNSS measurement through their Android platform. Currently, the greatest limitations in precise positioning with smartphone Global Navigation Satellite System (GNSS) sensors are the quality and availability of satellite-to-smartphone ranging measurements. Many papers have assessed the quality of GNSS pseudorange and carrier-phase measurements in various environments. In addition, there is growing research in the inclusion of a priori information to model signal blockage, multipath, etc. In this contribution, numerical estimation of actual range errors in smartphone GNSS precise positioning in realistic environments is performed using a geodetic receiver as a reference. The range errors are analyzed under various environments and by placing smartphones on car dashboards and roofs. The distribution of range errors and their correlation to prefit residuals is studied in detail. In addition, a comparison of range errors between different constellations is provided, aiming to provide insight into the quantitative understanding of measurement behavior. This information can be used to further improve measurement quality control, and optimize stochastic modeling and position estimation processes.

With changes in food preferences and life styles, more and more attentions have been focused on healthier food. Nowadays, resistant starch (RS) which can resist digestion in the human intestine has been recognized and accepted. High RS diet shows great benefit for the human health, and breeding high RS rice variety is a great target for realizing dietary intervention. To provide guidance for RS improvement in rice, this review summarized the unique physiochemical properties of RS and the possible approaches, i.e. genetic regulation, for enhancing RS content in rice, and proposed the potential ways to obtain rice variety with high RS content.

Natural killer (NK) cells are innate lymphoid cells (ILCs) contributing to immune responses to microbes and tumors. Historically, their classification hinged on a limited array of surface protein markers. Here, we used single-cell RNA sequencing (scRNA-seq) and cellular indexing of transcriptomes and epitopes by sequencing (CITE-seq) to dissect the heterogeneity of NK cells. We identified three prominent NK cell subsets in healthy human blood: NK1, NK2 and NK3, further differentiated into six distinct subgroups. Our findings delineate the molecular characteristics, key transcription factors, biological functions, metabolic traits and cytokine responses of each subgroup. These data also suggest two separate ontogenetic origins for NK cells, leading to divergent transcriptional trajectories. Furthermore, we analyzed the distribution of NK cell subsets in the lung, tonsils and intraepithelial lymphocytes isolated from healthy individuals and in 22 tumor types. This standardized terminology aims at fostering clarity and consistency in future research, thereby improving cross-study comparisons.

4D printing can be defined as the evolution of 3D printing structure in terms of shape, performance and function. It has time dependence, printer independence and predictability, and its smart dynamic performance creates promising capabilities and broad potential applications. On the basis of a brief review of the status of 4D printing at home and abroad, the concept and components of 4D printing were given firstly. Then the 4D printing was classified from the dimension of printing structure shape change. Furthermore, the key technologies such as printing materials, incentive mechanism and mathematical modeling method in 4D printing elements were analyzed. Finally, it was pointed out that the development direction of 4D printing technology is to combine intelligent materials with 3D printing, simplify the manufacture of complex structures, and realize the automation, intellectualization and personalization applications in special service environments and fields such as aerospace, deep sea and precise medical treatment by using its unique characteristics of self-assembly, self-adaption and self-repairing.

BackgroundSuperconducting undulator (SCU) prototype with small magnet gap of 5 mm, long magnet length of 4 m and high magnet field of 1.58 T was being developed at Shanghai High Repetition rate XFEL and Extreme light facility (SHINE). Compared to any other superconducting undulator, there is no cryocooler being installed on the cryostat in this SCU prototype.PurposeThis study aims at the cooling design for the binary current leads for SCU's normal operating.MethodsBinary current leads composed of normal conductive copper leads and high temperature superconducting current leads (HTS) were adopted for SCU to connect superconducting coils inside the cryostat and outer cables. Low-temperature helium gas was used to transport independent refrigerator system to the cooling tubes inside the prototype, hence the binary current leads were cooled. Thermal conduction components installed on the middle of the thermal shield were employed to transfer heat load of normal conductive copper leads, and heat load of copper leads was optimized by simulation. Auxiliary superconducting rods were designed for connecting cold ends of HTS in the cryostat test.ResultsThe temperature difference between hot ends of HTS and low-temperature helium gas is less than 20 K from the result of cryostat test, all binary current leads is operating normally with full current.ConclusionsIt is practicable to use cooling tubes with low-temperature helium gas to cool binary current leads of the SCU prototype by thermal conduction, which is different from cooling solution for current leads in any other SCU being developed presently.

Liposomes are microspheres that are similar to cell membranes. They have good sustained release, biocompatibility and targeting ability and can reduce the toxicity of encapsulated drugs. This article reviews the research progress of the use of liposomes in periodontal drug delivery systems and periodontal tissue engineering scaffolds. Liposomes have shown unique advantages and broad prospects in the field of periodontal drug delivery. Liposomes loaded with bioactive molecules and combined with periodontal tissue engineering scaffolds can improve the pharmacokinetics and local efficacy of these molecules. Modification of various extracellular matrix proteins on the surface of the scaffolds can promote the absorption of liposomes. Attachment of these proteins to the surface of the scaffold can reduce the requirement for bioactive molecules, improve the effective conversion rate and prolong the half-life of the scaffold in vivo. However, the development, clinical efficacy and safety evaluation of new liposomes still need to be further explored.

With the rapid development of intelligent transportation, various applications which have millisecond delay requirements appear in the vehicular heterogeneous network. Offloading these delay-sensitive applications into edge nodes is a trend and direction of development. However, with the increase in the number of vehicular applications, the conventional methods of distance-based edge node workload allocation make the workload allocation unbalanced, causing some edge nodes to be overloaded, resulting in response time of corresponding application being too long to meet low delay requirements. In this paper, we tackle the problem of edge node overload and propose a multipath transmission workload balancing optimization scheme, which uses multipath transmission in the edge computing architecture as the transport protocol support for the communications between the vehicles and the edge nodes and the real-time virtual machine (VM) migration happens between the edge nodes. First, the application is assigned to the edge node closest to each vehicle. When the workload of the edge node exceeds its capacity, the scheme iteratively selects the application with the longest response time. Second. if its response time exceeds the response time passed to the cloud computing center, it is assigned to the cloud computing center for processing; if not, it is reassigned to the standby edge to minimize its response time until all vehicle applications cannot find a better edge node. Then, computing resources are allocated to each edge node, and resources of different sizes are allocated to different types of VMs in each edge node through convex optimization. Finally, the extensive simulation results illustrate that the multipath transmission workload balancing optimization scheme can effectively reduce the average response time of the vehicular applications compared to existing schemes.

The Global Navigation Satellite System (GNSS) capability in smartphones has seen significant upgrades over the years. The latest ultra-low-cost GNSS receivers are capable of carrier-phase tracking and multi-constellation, dual-frequency signal reception. However, due to the limitations of these ultra-low-cost receivers and antennas, smartphone GNSS position solutions suffer significantly from urban multipath, poor signal reception, and signal blockage. This paper presents a novel sensor fusion technique using Precise Point Positioning (PPP) and the inertial sensors in smartphones, combined with a single- and dual-frequency (SFDF) optimisation scheme for smartphones. The smartphone is field-tested while attached to a vehicle’s dashboard and is driven in multiple real-world situations. A total of five vehicle experiments were conducted and the solutions show that SFDF-PPP outperforms single-frequency PPP (SF-PPP) and dual-frequency PPP (DF-PPP). Solutions can be further improved by integrating with native smartphone IMU measurements and provide consistent horizontal positioning accuracy of

Polygenic scores (PGSs) summarize the combined effect of common risk variants and are associated with breast cancer risk in patients without identifiable monogenic risk factors. One of the most well-validated PGSs in breast cancer to date is PGS313, which was developed from a Northern European biobank but has shown attenuated performance in non-European ancestries. We further investigate the generalizability of the PGS313 for American women of European (EA), African (AFR), Asian (EAA), and Latinx (HL) ancestry within one institution with a singular electronic health record (EHR) system, genotyping platform, and quality control process. We found that the PGS313 achieved overlapping areas under the receiver operator characteristic (ROC) curve (AUCs) in females of HL (AUC = 0.68, 95% confidence interval [CI] = 0.65-0.71) and EA ancestry (AUC = 0.70, 95% CI = 0.69-0.71) but lower AUCs for the AFR and EAA populations (AFR: AUC = 0.61, 95% CI = 0.56-0.65; EAA: AUC = 0.64, 95% CI = 0.60-0.680). While PGS313 is associated with hormone-receptor-positive (HR+) disease in EA Americans (odds ratio [OR] = 1.42, 95% CI = 1.16-1.64), this association is lost in African, Latinx, and Asian Americans. In summary, we found that PGS313 was significantly associated with breast cancer but with attenuated accuracy in women of AFR and EAA descent within a singular health system in Los Angeles. Our work further highlights the need for additional validation in diverse cohorts prior to the clinical implementation of PGSs.

Although Fe-Ni wires have numerous potential applications, the effect of heat treatments on the microstructures and properties of Fe-Ni wires is currently unclear. In this study, different high-temperature annealing and low-temperature aging treatments (i.e., ① annealing at 950℃ for 3 h+quenching, ② annealing at 950℃ for 3 h+quenching+aging at 500℃ for 2 h, and ③ aging at 500℃ for 2 h) were applied to cold-drawn Fe-36.24% Ni alloy wires to comparatively investigate their influences on the microstructural evolution, tensile strength, and thermal expansion coefficient, with the aid of microstructural characterization methods, such as X-ray diffraction, optical microscopy, atomic force microscopy, and transmission electron microscopy, as well as property measurements, such as room-temperature tensile testing and thermal expansion coefficient. The experimental results clearly show that the as-drawn Fe-Ni wire, although having a high tensile strength, exhibits an unfavorable high thermal expansion coefficient. The Fe-Ni wires annealed at 950℃ (wires subjected to ① and ②) have a relatively low thermal expansion coefficient but exhibit insufficient strength. In comparison, the wire aged at 500℃ (wire subjected to ③) shows a high strength (1189 MPa) and a low thermal expansion coefficient (0.2×10-6℃-1) at the same time. The relative strengthening mechanisms and factors affecting the thermal expansion coefficient are discussed and analyzed in terms of the microstructures. Grain boundary strengthening and dislocation hardening are observed to be the dominant strengthening mechanisms of the Fe-Ni wires, and the solute atom-dislocation interaction is mainly responsible for the evolution of the thermal expansion coefficient. The present work clearly demonstrates that suitable heat treatments are important for the optimization of the strength/thermal expansion coefficient of Fe-Ni alloy wires, which will be helpful for material design and technology tailoring of Fe-Ni wires to develop a new alloy with enhanced performance.