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4. Characterization of compliance phenotypes in COVID-19 acute respiratory distress syndrome

Author

Zacchetti, L, Longhi, L, Bianchi, I, Di Matteo, M, Russo, F, Gandini, L, Manesso, L, Monti, M, Cosentini, R, Di Marco, F, Fagiuoli, S, Grazioli, L, Gritti, P, Previdi, F, Senni, M, Ranieri, M, Lorini, L, Rota, A, Martinelli, A, Pugni, P, Marino, A, Colombo, G, Damiani, M, Ferrari, D, Bonacina, D, Corbella, D, Poli, G, Cantu, D, Ferri, F, Brivio, M, Bonanomi, E, Fabretti, F, Benigni, A, Brambillasca, P, Scarpa, L, Marchesi, F, Zacchetti L., Longhi L., Bianchi I., Di Matteo M., Russo F., Gandini L., Manesso L., Monti M., Cosentini R., Di Marco F., Fagiuoli S., Grazioli L., Gritti P., Previdi F., Senni M., Ranieri M., Lorini L., Rota A., Martinelli A., Pugni P., Marino A., Colombo G., Damiani M., Ferrari D., Bonacina D., Corbella D., Poli G., Cantu D., Ferri F., Brivio M., Bonanomi E., Fabretti F., Benigni A., Brambillasca P., Scarpa L., Marchesi F., Zacchetti, L, Longhi, L, Bianchi, I, Di Matteo, M, Russo, F, Gandini, L, Manesso, L, Monti, M, Cosentini, R, Di Marco, F, Fagiuoli, S, Grazioli, L, Gritti, P, Previdi, F, Senni, M, Ranieri, M, Lorini, L, Rota, A, Martinelli, A, Pugni, P, Marino, A, Colombo, G, Damiani, M, Ferrari, D, Bonacina, D, Corbella, D, Poli, G, Cantu, D, Ferri, F, Brivio, M, Bonanomi, E, Fabretti, F, Benigni, A, Brambillasca, P, Scarpa, L, Marchesi, F, Zacchetti L., Longhi L., Bianchi I., Di Matteo M., Russo F., Gandini L., Manesso L., Monti M., Cosentini R., Di Marco F., Fagiuoli S., Grazioli L., Gritti P., Previdi F., Senni M., Ranieri M., Lorini L., Rota A., Martinelli A., Pugni P., Marino A., Colombo G., Damiani M., Ferrari D., Bonacina D., Corbella D., Poli G., Cantu D., Ferri F., Brivio M., Bonanomi E., Fabretti F., Benigni A., Brambillasca P., Scarpa L., and Marchesi F.

Abstract

Background: Coronavirus disease 2019-associated acute respiratory distress syndrome (COVID-19 ARDS) seems to differ from the “classic ARDS”, showing initial significant hypoxemia in the face of relatively preserved compliance and evolving later in a scenario of poorly compliant lungs. We tested the hypothesis that in patients with COVID-19 ARDS, the initial value of static compliance of respiratory system (Crs) (1) depends on the previous duration of the disease (i.e., the fewer days of illness, the higher the Crs and vice versa) and (2) identifies different lung patterns of time evolution and response to prone positioning. Methods: This was a single-center prospective observational study. We enrolled consecutive mechanically ventilated patients with a diagnosis of COVID-19 who met ARDS criteria, admitted to intensive care unit (ICU). Patients were divided in four groups based on quartiles of initial Crs. Relationship between Crs and the previous duration of the disease was evaluated. Respiratory parameters collected once a day and during prone positioning were compared between groups. Results: We evaluated 110 mechanically ventilated patients with a diagnosis of COVID-19 who met ARDS criteria admitted to our ICUs. Patients were divided in groups based on quartiles of initial Crs. The median initial Crs was 41 (32–47) ml/cmH2O. No association was found between the previous duration of the disease and the initial Crs. The Crs did not change significantly over time within each quartile. Positive end-expiratory pressure (PEEP) and driving pressure were respectively lower and greater in patients with lower Crs. Prone positioning significantly improved PaO2/FiO2 in the 4 groups, however it increased the Crs significantly only in patients in lower quartile of Crs. Conclusions: In our cohort, the initial Crs is not dependent on the previous duration of COVID-19 disease. Prone positioning improves oxygenation irrespective to initial Crs, but it ameliorates respiratory mecha

Published
2022

7. Characterization of compliance phenotypes in COVID-19 acute respiratory distress syndrome

Author

Zacchetti L., Longhi L., Bianchi I., Di Matteo M., Russo F., Gandini L., Manesso L., Monti M., Cosentini R., Di Marco F., Fagiuoli S., Grazioli L., Gritti P., Previdi F., Senni M., Ranieri M., Lorini L., Rota A., Martinelli A., Pugni P., Marino A., Colombo G., Damiani M., Ferrari D., Bonacina D., Corbella D., Poli G., Cantu D., Ferri F., Brivio M., Bonanomi E., Fabretti F., Benigni A., Brambillasca P., Scarpa L., Marchesi F., Zacchetti, L, Longhi, L, Bianchi, I, Di Matteo, M, Russo, F, Gandini, L, Manesso, L, Monti, M, Cosentini, R, Di Marco, F, Fagiuoli, S, Grazioli, L, Gritti, P, Previdi, F, Senni, M, Ranieri, M, Lorini, L, Rota, A, Martinelli, A, Pugni, P, Marino, A, Colombo, G, Damiani, M, Ferrari, D, Bonacina, D, Corbella, D, Poli, G, Cantu, D, Ferri, F, Brivio, M, Bonanomi, E, Fabretti, F, Benigni, A, Brambillasca, P, Scarpa, L, and Marchesi, F

Subjects
Pulmonary and Respiratory Medicine, Respiratory Distress Syndrome, Acute respiratory distress syndrome, Coronaviru, COVID-19, Prone positioning, Respiration, Artificial, Coronavirus, Positive-Pressure Respiration, Phenotype, Sars coronaviru, Settore ING-INF/04 - Automatica, Acute lung injury, Lung compliance, Sars coronavirus, Humans, Lung Compliance
Abstract

Background Coronavirus disease 2019-associated acute respiratory distress syndrome (COVID-19 ARDS) seems to differ from the “classic ARDS”, showing initial significant hypoxemia in the face of relatively preserved compliance and evolving later in a scenario of poorly compliant lungs. We tested the hypothesis that in patients with COVID-19 ARDS, the initial value of static compliance of respiratory system (Crs) (1) depends on the previous duration of the disease (i.e., the fewer days of illness, the higher the Crs and vice versa) and (2) identifies different lung patterns of time evolution and response to prone positioning. Methods This was a single-center prospective observational study. We enrolled consecutive mechanically ventilated patients with a diagnosis of COVID-19 who met ARDS criteria, admitted to intensive care unit (ICU). Patients were divided in four groups based on quartiles of initial Crs. Relationship between Crs and the previous duration of the disease was evaluated. Respiratory parameters collected once a day and during prone positioning were compared between groups. Results We evaluated 110 mechanically ventilated patients with a diagnosis of COVID-19 who met ARDS criteria admitted to our ICUs. Patients were divided in groups based on quartiles of initial Crs. The median initial Crs was 41 (32–47) ml/cmH2O. No association was found between the previous duration of the disease and the initial Crs. The Crs did not change significantly over time within each quartile. Positive end-expiratory pressure (PEEP) and driving pressure were respectively lower and greater in patients with lower Crs. Prone positioning significantly improved PaO2/FiO2 in the 4 groups, however it increased the Crs significantly only in patients in lower quartile of Crs. Conclusions In our cohort, the initial Crs is not dependent on the previous duration of COVID-19 disease. Prone positioning improves oxygenation irrespective to initial Crs, but it ameliorates respiratory mechanics only in patients with lower Crs.

Published
2022
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9. Reduction of painful area as new possible therapeutic target in post-herpetic neuropathic pain treated with 5% lidocaine medicated plaster: a case series

Author

Casale R, Di Matteo M, Minella CE, Fanelli G, and Allegri M

Subjects
Medicine (General), R5-920
Abstract

Roberto Casale,1,2 Maria Di Matteo,3,7 Cristina E Minella,4,7 Guido Fanelli,5,7 Massimo Allegri4,6,71Department of Clinical Neurophysiology and Pain Rehabilitation Unit, Foundation Salvatore Maugeri, IRCCS, Pavia, 2EFIC Montescano School, Montescano, 3Anesthesia and Intensive Care I, 4Pain Therapy Service, Fondazione IRCCS Policlinico San Matteo, Pavia, 5Department of Anesthesia, Intensive Care and Pain Therapy, Azienda Ospedaliera Universitaria Parma, University of Parma, Parma, 6Department of Clinical, Surgical, Diagnostic and Pediatric Science, University of Pavia, Pavia, 7Study In Multidisciplinary Pain Research Group, Parma, ItalyAbstract: Post-herpetic neuralgia (PHN) is neuropathic pain persisting after an acute episode of herpes zoster, and is associated with severe pain and sensory abnormalities that adversely affect the patient's quality of life and increase health care costs. Up to 83% of patients with PHN describe localized neuropathic pain, defined as “a type of neuropathic pain characterized by consistent and circumscribed area(s) of maximum pain”. Topical treatments have been suggested as a first-line treatment for localized neuropathic pain. Use of 5% lidocaine medicated plaster could reduce abnormal nervous peripheral discharge and via the plaster could have a “protective” function in the affected area. It has been suggested that use of this plaster could reduce pain as well as the size of the painful area. To evaluate this possible outcome, we retrospectively reviewed eight patients with PHN, treated using 5% lidocaine medicated plaster. During a follow-up period of 3 months, we observed good pain relief, which was associated with a 46% reduction in size of the painful area after one month (from 236.38±140.34 cm2 to 128.80±95.7 cm2) and a 66% reduction after 3 months (81.38±59.19 cm2). Our study cohort was composed mainly of elderly patients taking multiple drugs to treat comorbidities, who have a high risk of drug–drug interactions. Such patients benefit greatly from topical treatment of PHN. Our observations confirm the effectiveness of lidocaine plasters in the treatment of PHN, indicating that 5% lidocaine medicated plaster could reduce the size of the painful area. This last observation has to be confirmed and the mechanisms clarified in appropriate larger randomized controlled trials.Keywords: localized neuropathic pain, topical treatment, chronic pain, drug–drug interactions, patient's outcome

Published
2014

11. Coagulopathy and COVID-19

Author

Lorini, L, Di Matteo, M, Gritti, P, Grazioli, L, Benigni, A, Zacchetti, L, Bianchi, I, Fabretti, F, Longhi, L, Luca Lorini, Maria Di Matteo, Paolo Gritti, Lorenzo Grazioli, Alberto Benigni, Lucia Zacchetti, Isabella Bianchi, Fabrizio Fabretti, Luca Longhi, Lorini, L, Di Matteo, M, Gritti, P, Grazioli, L, Benigni, A, Zacchetti, L, Bianchi, I, Fabretti, F, Longhi, L, Luca Lorini, Maria Di Matteo, Paolo Gritti, Lorenzo Grazioli, Alberto Benigni, Lucia Zacchetti, Isabella Bianchi, Fabrizio Fabretti, and Luca Longhi

Abstract

SARS-CoV-2 infection is associated with frequent thrombotic events, at the micro and macro-vascular level, due to the perpetuation of a state of hypercoagulability. The so-called 'COVID-19 associated coagulopathy' (CAC) represents a key aspect in the genesis of organ damage from SARS-CoV-2. The main coagulative alterations described in the literature are represented by high levels of D-dimer and fibrinogen. Although CAC has some common features with disseminated intravascular coagulation and sepsis-induced coagulopathy, there are important differences between these clinical pictures and the phenotype of CAC is unique. The pathogenesis of CAC is complex and is affected by the strong interconnection between the inflammatory system and coagulation, in the phenomenon of immunothrombosis and thromboinflammation. Several mechanisms come into play, such as inflammatory cytokines, neutrophils, the complement system as well as an alteration of the fibrinolytic system. Finally, an altered platelet function and especially endothelial dysfunction also play a central role in the pathophysiology of CAC. Heparin has several potential effects in CAC, in fact in addition to the anticoagulant effect, it could have a direct antiviral effect and anti-inflammatory properties. The high incidence of thromboembolic phenomena despite the use of antithrombotic prophylaxis have led some experts to recommend the use of anticoagulant doses of heparin, but at present the optimal anticoagulant regimen remains to be determined.

Published
2021

14. CHANGES IN PHYSICO-CHEMICAL TRAITS AND ENZYMES OXIDATIVE SYSTEM DURING COLD STORAGE OF 'FORMOSA' PAPAYA FRESH CUT FRUITS GROWN IN THE MEDITERRANEAN AREA (SICILY).

Author

ADILETTA, G., DI MATTEO, M., ALBANESE, D., FARINA, V., CINQUANTA, L., CORONA, O., MAGRI, A., and PETRICCIONE, M.

Subjects
*COLD storage, *FRUIT growing, *PAPAYA, *ENZYMES, *SUPEROXIDE dismutase, *HUMIDITY
Abstract

In this study, the effects of cold storage (5±0.5°C and relative humidity of 90±1%) on the quality of fresh papaya slices packed in a passive atmosphere with a semi-permeable film were evaluated. Physico-chemical traits such as total soluble solids, reducing sugar, pH increased during storage as well as the polyphenols, carotenoid content and antioxidant activity that reaching the highest values at end of trials. Changes in colorimetric parameters resulted in a significant decrease after 4 days of hue angle values, which then remained constant. The cutting process enhanced the antioxidant enzymes activity such as superoxide dismutase, catalase and ascorbate peroxidase. The analysis of the main components showed physical-chemical, qualitative, and enzymatic changes in papaya samples during cold storage, showing a shift from negative to positive values along the PC1 and indicating a qualitative decay of sliced papaya. [ABSTRACT FROM AUTHOR]

Published
2020

15. The mTOR and PP2A pathways regulate PHD2 phosphorylation to fine-tune HIF1α levels and colorectal cancer cell survival under hypoxia

Author

Di Conza , G. (Giusy), Trusso Cafarello, S. (Sarah), Loroch, S. (Stefan), Mennerich, D. (Daniela), Deschoemaeker, S. (Sofie), Di Matteo, M. (Mario), Ehling, M. (Manuel), Gevaert , K. (Kris), Prenen, H. (Hans), Peiman Zahedi, R. (Rene), Sickmann, A. (Albert), Kietzmann, T. (Thomas), Moretti, F. (Fabiola), Mazzone, M. (Massimiliano), Di Conza , G. (Giusy), Trusso Cafarello, S. (Sarah), Loroch, S. (Stefan), Mennerich, D. (Daniela), Deschoemaeker, S. (Sofie), Di Matteo, M. (Mario), Ehling, M. (Manuel), Gevaert , K. (Kris), Prenen, H. (Hans), Peiman Zahedi, R. (Rene), Sickmann, A. (Albert), Kietzmann, T. (Thomas), Moretti, F. (Fabiola), and Mazzone, M. (Massimiliano)

Abstract

Summary Oxygen-dependent HIF1α hydroxylation and degradation are strictly controlled by PHD2. In hypoxia, HIF1α partly escapes degradation because of low oxygen availability. Here, we show that PHD2 is phosphorylated on serine 125 (S125) by the mechanistic target of rapamycin (mTOR) downstream kinase P70S6K and that this phosphorylation increases its ability to degrade HIF1α. mTOR blockade in hypoxia by REDD1 restrains P70S6K and unleashes PP2A phosphatase activity. Through its regulatory subunit B55α, PP2A directly dephosphorylates PHD2 on S125, resulting in a further reduction of PHD2 activity that ultimately boosts HIF1α accumulation. These events promote autophagy-mediated cell survival in colorectal cancer (CRC) cells. B55α knockdown blocks neoplastic growth of CRC cells in vitro and in vivo in a PHD2-dependent manner. In patients, CRC tissue expresses higher levels of REDD1, B55α, and HIF1α but has lower phospho-S125 PHD2 compared with a healthy colon. Our data disclose a mechanism of PHD2 regulation that involves the mTOR and PP2A pathways and controls tumor growth.

Published
2017

16. 37th International Symposium on Intensive Care and Emergency Medicine (part 2 of 3)

Author

Rob, D., primary, Špunda, R., additional, Lindner, J., additional, Šmalcová, J., additional, Šmíd, O., additional, Kovárník, T., additional, Linhart, A., additional, Bìlohlávek, J., additional, Marinoni, M. M., additional, Cianchi, G., additional, Trapani, S., additional, Migliaccio, M. L., additional, Gucci, L., additional, Bonizzoli, M., additional, Cramaro, A., additional, Cozzolino, M., additional, Valente, S., additional, Peris, A., additional, Grins, E., additional, Kort, E., additional, Weiland, M., additional, Shresta, N. Manandhar, additional, Davidson, P., additional, Algotsson, L., additional, Fitch, S., additional, Marco, G., additional, Sturgill, J., additional, Lee, S., additional, Dickinson, M., additional, Boeve, T., additional, Khaghani, A., additional, Wilton, P., additional, Jovinge, S., additional, Ahmad, A. N., additional, Loveridge, R., additional, Vlachos, S., additional, Patel, S., additional, Gelandt, E., additional, Morgan, L., additional, Butt, S., additional, Whitehorne, M., additional, Kakar, V., additional, Park, C., additional, Hayes, M., additional, Willars, C., additional, Hurst, T., additional, Best, T., additional, Vercueil, A., additional, Auzinger, G., additional, Adibelli, B., additional, Akovali, N., additional, Torgay, A., additional, Zeyneloglu, P., additional, Pirat, A., additional, Kayhan, Z., additional, Schmidbauer, S. S., additional, Herlitz, J., additional, Karlsson, T., additional, Friberg, H., additional, Knafelj, R., additional, Radsel, P., additional, Duprez, F., additional, Bonus, T., additional, Cuvelier, G., additional, Mashayekhi, S., additional, Maka, M., additional, Ollieuz, S., additional, Reychler, G., additional, Mosaddegh, R., additional, Abbasi, S., additional, Talaee, S., additional, Zotzmann, V. Z., additional, Staudacher, D. S., additional, Wengenmayer, T. W., additional, Dürschmied, D. D., additional, Bode, C. B., additional, Nelskylä, A., additional, Nurmi, J., additional, Jousi, M., additional, Schramko, A., additional, Mervaala, E., additional, Ristagno, G., additional, Skrifvars, M., additional, Ozsoy, G., additional, Kendirli, T., additional, Azapagasi, E., additional, Perk, O., additional, Gadirova, U., additional, Ozcinar, E., additional, Cakici, M., additional, Baran, C., additional, Durdu, S., additional, Uysalel, A., additional, Dogan, M., additional, Ramoglu, M., additional, Ucar, T., additional, Tutar, E., additional, Atalay, S., additional, Akar, R., additional, Kamps, M., additional, Leeuwerink, G., additional, Hofmeijer, J., additional, Hoiting, O., additional, Van der Hoeven, J., additional, Hoedemaekers, C., additional, Konkayev, A., additional, Kuklin, V., additional, Kondratyev, T., additional, Konkayeva, M., additional, Akhatov, N., additional, Sovershaev, M., additional, Tveita, T., additional, Dahl, V., additional, Wihersaari, L., additional, Skrifvars, M. B., additional, Bendel, S., additional, Kaukonen, K. M., additional, Vaahersalo, J., additional, Romppanen, J., additional, Pettilä, V., additional, Reinikainen, M., additional, Lybeck, A., additional, Cronberg, T., additional, Nielsen, N., additional, Rauber, M., additional, Steblovnik, K., additional, Jazbec, A., additional, Noc, M., additional, Kalasbail, P., additional, Garrett, F., additional, Kulstad, E., additional, Bergström, D. J., additional, Olsson, H. R., additional, Schmidbauer, S., additional, Mandel, I., additional, Mikheev, S., additional, Podoxenov, Y., additional, Suhodolo, I., additional, Podoxenov, A., additional, Svirko, J., additional, Sementsov, A., additional, Maslov, L., additional, Shipulin, V., additional, Vammen, L. V., additional, Rahbek, S. R., additional, Secher, N. S., additional, Povlsen, J. P., additional, Jessen, N. J., additional, Løfgren, B. L., additional, Granfeldt, A. G., additional, Grossestreuer, A., additional, Perman, S., additional, Patel, P., additional, Ganley, S., additional, Portmann, J., additional, Cocchi, M., additional, Donnino, M., additional, Nassar, Y., additional, Fathy, S., additional, Gaber, A., additional, Mokhtar, S., additional, Chia, Y. C., additional, Lewis-Cuthbertson, R., additional, Mustafa, K., additional, Sabra, A., additional, Evans, A., additional, Bennett, P., additional, Eertmans, W., additional, Genbrugge, C., additional, Boer, W., additional, Dens, J., additional, De Deyne, C., additional, Jans, F., additional, Skorko, A., additional, Thomas, M., additional, Casadio, M., additional, Coppo, A., additional, Vargiolu, A., additional, Villa, J., additional, Rota, M., additional, Avalli, L., additional, Citerio, G., additional, Moon, J. B., additional, Cho, J. H., additional, Park, C. W., additional, Ohk, T. G., additional, Shin, M. C., additional, Won, M. H., additional, Papamichalis, P., additional, Zisopoulou, V., additional, Dardiotis, E., additional, Karagiannis, S., additional, Papadopoulos, D., additional, Zafeiridis, T., additional, Babalis, D., additional, Skoura, A., additional, Staikos, I., additional, Komnos, A., additional, Passos, S. Silva, additional, Maeda, F., additional, Souza, L. Silva, additional, Filho, A. Amato, additional, Granjeia, T. Araújo Guerra, additional, Schweller, M., additional, Franci, D., additional, De Carvalho Filho, M., additional, Santos, T. Martins, additional, De Azevedo, P., additional, Wall, R., additional, Welters, I., additional, Tansuwannarat, P., additional, Sanguanwit, P., additional, Langer, T., additional, Carbonara, M., additional, Caccioppola, A., additional, Fusarini, C. Ferraris, additional, Carlesso, E., additional, Paradiso, E., additional, Battistini, M., additional, Cattaneo, E., additional, Zadek, F., additional, Maiavacca, R., additional, Stocchetti, N., additional, Pesenti, A., additional, Ramos, A., additional, Acharta, F., additional, Toledo, J., additional, Perezlindo, M., additional, Lovesio, L., additional, Dogliotti, A., additional, Lovesio, C., additional, Schroten, N., additional, Van der Veen, B., additional, De Vries, M. C., additional, Veenstra, J., additional, Abulhasan, Y. B., additional, Rachel, S., additional, Châtillon-Angle, M., additional, Alabdulraheem, N., additional, Schiller, I., additional, Dendukuri, N., additional, Angle, M., additional, Frenette, C., additional, Lahiri, S., additional, Schlick, K., additional, Mayer, S. A., additional, Lyden, P., additional, Akatsuka, M., additional, Arakawa, J., additional, Yamakage, M., additional, Rubio, J., additional, Mateo-Sidron, J. A. Rubio, additional, Sierra, R., additional, Celaya, M., additional, Benitez, L., additional, Alvarez-Ossorio, S., additional, Fernandez, A., additional, Gonzalez, O., additional, Engquist, H., additional, Rostami, E., additional, Enblad, P., additional, Canullo, L., additional, Nallino, J., additional, Perreault, M., additional, Talic, J., additional, Frenette, A. J., additional, Burry, L., additional, Bernard, F., additional, Williamson, D. R., additional, Adukauskiene, D., additional, Cyziute, J., additional, Adukauskaite, A., additional, Malciene, L., additional, Luca, L., additional, Rogobete, A., additional, Bedreag, O., additional, Papurica, M., additional, Sarandan, M., additional, Cradigati, C., additional, Popovici, S., additional, Vernic, C., additional, Sandesc, D., additional, Avakov, V., additional, Shakhova, I., additional, Trimmel, H., additional, Majdan, M., additional, Herzer, G. H., additional, Sokoloff, C. S., additional, Albert, M., additional, Williamson, D., additional, Odier, C., additional, Giguère, J., additional, Charbonney, E., additional, Husti, Z., additional, Kaptás, T., additional, Fülep, Z., additional, Gaál, Z., additional, Tusa, M., additional, Donnelly, J., additional, Aries, M., additional, Czosnyka, M., additional, Robba, C., additional, Liu, M., additional, Ercole, A., additional, Menon, D., additional, Hutchinson, P., additional, Smielewski, P., additional, López, R., additional, Graf, J., additional, Montes, J. M., additional, Kenawi, M., additional, Kandil, A., additional, Husein, K., additional, Samir, A., additional, Heijneman, J., additional, Huijben, J., additional, Abid-Ali, F., additional, Stolk, M., additional, Van Bommel, J., additional, Lingsma, H., additional, Van der Jagt, M., additional, Cihlar, R. C., additional, Mancino, G., additional, Bertini, P., additional, Forfori, F., additional, Guarracino, F., additional, Pavelescu, D., additional, Grintescu, I., additional, Mirea, L., additional, Alamri, S., additional, Tharwat, M., additional, Kono, N., additional, Okamoto, H., additional, Uchino, H., additional, Ikegami, T., additional, Fukuoka, T., additional, Simoes, M., additional, Trigo, E., additional, Coutinho, P., additional, Pimentel, J., additional, Franci, A., additional, Basagni, D., additional, Boddi, M., additional, Anichini, V., additional, Cecchi, A., additional, Markopoulou, D., additional, Venetsanou, K., additional, Papanikolaou, I., additional, Barkouri, T., additional, Chroni, D., additional, Alamanos, I., additional, Cingolani, E., additional, Bocci, M. G., additional, Pisapia, L., additional, Tersali, A., additional, Cutuli, S. L., additional, Fiore, V., additional, Palma, A., additional, Nardi, G., additional, Antonelli, M., additional, Coke, R., additional, Kwong, A., additional, Dwivedi, D. J., additional, Xu, M., additional, McDonald, E., additional, Marshall, J. C., additional, Fox-Robichaud, A. E., additional, Liaw, P. C., additional, Kuchynska, I., additional, Malysh, I. R., additional, Zgrzheblovska, L. V., additional, Mestdagh, L., additional, Verhoeven, E. F., additional, Hubloue, I., additional, Ruel-laliberte, J., additional, Zarychanski, R., additional, Lauzier, F., additional, Bonaventure, P. Lessard, additional, Green, R., additional, Griesdale, D., additional, Fowler, R., additional, Kramer, A., additional, Zygun, D., additional, Walsh, T., additional, Stanworth, S., additional, Léger, C., additional, Turgeon, A. F., additional, Baron, D. M., additional, Baron-Stefaniak, J., additional, Leitner, G. C., additional, Ullrich, R., additional, Tarabrin, O., additional, Mazurenko, A., additional, Potapchuk, Y., additional, Sazhyn, D., additional, Tarabrin, P., additional, Pérez, A. González, additional, Silva, J., additional, Artemenko, V., additional, Bugaev, A., additional, Tokar, I., additional, Konashevskaya, S., additional, Kolesnikova, I. M., additional, Roitman, E. V., additional, Kiss, T. Rengeiné, additional, Máthé, Z., additional, Piros, L., additional, Dinya, E., additional, Tihanyi, E., additional, Smudla, A., additional, Fazakas, J., additional, Ubbink, R., additional, Boekhorst te, P., additional, Mik, E., additional, Caneva, L., additional, Ticozzelli, G., additional, Pirrelli, S., additional, Passador, D., additional, Riccardi, F., additional, Ferrari, F., additional, Roldi, E. M., additional, Di Matteo, M., additional, Bianchi, I., additional, Iotti, G. A., additional, Zurauskaite, G., additional, Voegeli, A., additional, Meier, M., additional, Koch, D., additional, Haubitz, S., additional, Kutz, A., additional, Bargetzi, M., additional, Mueller, B., additional, Schuetz, P., additional, Von Meijenfeldt, G., additional, Van der Laan, M., additional, Zeebregts, C., additional, Christopher, K. B., additional, Vernikos, P., additional, Melissopoulou, T., additional, Kanellopoulou, G., additional, Panoutsopoulou, M., additional, Xanthis, D., additional, Kolovou, K., additional, Kypraiou, T., additional, Floros, J., additional, Broady, H., additional, Pritchett, C., additional, Marshman, M., additional, Jannaway, N., additional, Ralph, C., additional, Lehane, C. L., additional, Keyl, C. K., additional, Zimmer, E. Z., additional, Trenk, D. T., additional, Ducloy-Bouthors, A. S., additional, Jonard, M. 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Aroca, additional, Valarezo, L. Jaramillo, additional, De Pablo Sánchez, R., additional, Real, A. Quinza, additional, Wigmore, T. W., additional, Bendavid, I., additional, Cohen, J., additional, Avisar, I., additional, Serov, I., additional, Kagan, I., additional, Singer, P., additional, Hanison, J, additional, Mirza, U, additional, Conway, D, additional, Takasu, A., additional, Tanaka, H., additional, Otani, N., additional, Ohde, S., additional, Ishimatsu, S., additional, Coffey, F, additional, Dissmann, P, additional, Mirza, K, additional, Lomax, M, additional, Dissmann, P., additional, Coffey, F., additional, Mirza, K., additional, Lomax, M., additional, Miner, JR, additional, Leto, R, additional, Markota, AM, additional, Gradišek, PG, additional, Aleksejev, VA, additional, Sinkovič, AS, additional, Romagnoli, S., additional, Chelazzi, C., additional, Zagli, G., additional, Benvenuti, F., additional, Mancinelli, P., additional, Boninsegni, P., additional, Paparella, L., additional, Bos, A. T., additional, Thomas, O., additional, Goslar, T., additional, Martone, A., additional, Sandu, P. R., additional, Rosu, V. A., additional, Capilnean, A., additional, Murgoi, P., additional, Lecavalier, A., additional, Jayaraman, D., additional, Rico, P., additional, Bellemare, P., additional, Gelinas, C., additional, Nishida, T., additional, Kinoshita, T., additional, Iwata, N., additional, Yamakawa, K., additional, Fujimi, S., additional, Maggi, L., additional, Sposato, F., additional, Citterio, G., additional, Bonarrigo, C., additional, Rocco, M., additional, Zani, V., additional, De Blasi, R. A., additional, Alcorn, D, additional, Barry, L, additional, Riedijk, M. A., additional, Milstein, D. M., additional, Caldas, J., additional, Panerai, R., additional, Camara, L., additional, Ferreira, G., additional, Bor-Seng-Shu, E., additional, Lima, M., additional, Galas, F., additional, Mian, N., additional, Nogueira, R., additional, de Oliveira, G. Queiroz, additional, Almeida, J., additional, Jardim, J., additional, Robinson, T. G., additional, Gaioto, F., additional, Hajjar, L. A., additional, Zabolotskikh, I., additional, Musaeva, T., additional, Saasouh, W., additional, Freeman, J., additional, Turan, A., additional, Saseedharan, S., additional, Pathrose, E., additional, Poojary, S., additional, Messika, J., additional, Martin, Y., additional, Maquigneau, N., additional, Henry-Lagarrigue, M., additional, Puechberty, C., additional, Stoclin, A., additional, Martin-Lefevre, L., additional, Blot, F., additional, Dreyfuss, D., additional, Dechanet, A., additional, Hajage, D., additional, Ricard, J., additional, Almeida, E., additional, Landoni, G., additional, Fukushima, J., additional, Fominskiy, E., additional, De Brito, C., additional, Cavichio, L., additional, Almeida, L., additional, Ribeiro, U., additional, Osawa, E., additional, Boltes, R., additional, Battistella, L., additional, Hajjar, L., additional, Fontela, P., additional, Lisboa, T., additional, Junior, L. Forgiarini, additional, Friedman, G. F., additional, Abruzzi, F., additional, Primo, J. Azevedo Peixoto, additional, Filho, P. Marques, additional, de Andrade, J. Stormorvski, additional, Brenner, K. Matos, additional, boeira, M. Scorsato, additional, Leães, C., additional, Rodrigues, C., additional, Vessozi, A., additional, Machado, A. SantAnna, additional, Weiler, M., additional, Bryce, H., additional, Hudson, A., additional, Law, T., additional, Reece-Anthony, R., additional, Molokhia, A., additional, Abtahinezhadmoghaddam, F., additional, Cumber, E., additional, Channon, L., additional, Wong, A., additional, Groome, R., additional, Gearon, D., additional, Varley, J., additional, Wilson, A., additional, Reading, J., additional, Zampieri, F. G., additional, Bozza, F. A., additional, Ferez, M., additional, Fernandes, H., additional, Japiassú, A., additional, Verdeal, J., additional, Carvalho, A. C., additional, Knibel, M., additional, Salluh, J. I., additional, Soares, M., additional, Gao, J., additional, Ahmadnia, E., additional, Patel, B., additional, MacKay, A., additional, Binning, S., additional, Pugh, R. J., additional, Battle, C., additional, Hancock, C., additional, Harrison, W., additional, Szakmany, T., additional, Mulders, F., additional, Vandenbrande, J., additional, Dubois, J., additional, Stessel, B., additional, Siborgs, K., additional, Ramaekers, D., additional, Silva, U. V., additional, Homena, W. S., additional, Fernandes, G. C., additional, Moraes, A. P., additional, Brauer, L., additional, Lima, M. F., additional, De Marco, F., additional, Maric, N., additional, Mackovic, M., additional, Udiljak, N., additional, Bosso, CE, additional, Caetano, RD, additional, Cardoso, AP, additional, Souza, OA, additional, Pena, R, additional, Mescolotte, MM, additional, Souza, IA, additional, Mescolotte, GM, additional, Bangalore, H., additional, Borrows, E., additional, Barnes, D., additional, Ferreira, V., additional, Azevedo, L., additional, Alencar, G., additional, Andrade, A., additional, Bierrenbach, A., additional, Buoninsegni, L. Tadini, additional, Cecci, L., additional, Lindskog, J., additional, Rowland, K., additional, Sturgess, P., additional, Ankuli, A., additional, Rosa, R, additional, Tonietto, T, additional, Ascoli, A, additional, Madeira, L, additional, Rutzen, W, additional, Falavigna, M, additional, Robinson, C, additional, Salluh, J, additional, Cavalcanti, A, additional, Azevedo, L, additional, Cremonese, R, additional, Da Silva, D, additional, Dornelles, A, additional, Skrobik, Y, additional, Teles, J, additional, Ribeiro, T, additional, Eugênio, C, additional, Teixeira, C, additional, Zarei, M., additional, Hashemizadeh, H., additional, Eriksson, M., additional, Strandberg, G., additional, Lipcsey, M., additional, Larsson, A., additional, Lignos, M., additional, Crissanthopoulou, E., additional, Flevari, K., additional, Dimopoulos, P., additional, Armaganidis, A., additional, Golub, JG, additional, Stožer, AS, additional, Rüddel, H., additional, Ehrlich, C., additional, Burghold, C. M., additional, Hohenstein, C., additional, Winning, J., additional, Sellami, W., additional, Hajjej, Z., additional, Bousselmi, M., additional, Gharsallah, H., additional, Labbene, I., additional, Ferjani, M., additional, Sattler, J., additional, Steinbrunner, D., additional, Poppert, H., additional, Schneider, G., additional, Blobner, M., additional, Kanz, K. G., additional, Schaller, S. J., additional, Apap, K., additional, Xuereb, G., additional, Massa, L., additional, Delvau, N., additional, Penaloza, A, additional, Liistro, G, additional, Thys, F, additional, Delattre, I. K., additional, Hantson, P., additional, Roy, P. M., additional, Gianello, P., additional, Hadîrcă, L, additional, Ghidirimschi, A, additional, Catanoi, N, additional, Scurtov, N, additional, Bagrinovschi, M, additional, Sohn, Y. S., additional, Cho, Y. C., additional, Golovin, B., additional, Creciun, O., additional, Ghidirimschi, A., additional, Bagrinovschi, M., additional, Tabbara, R., additional, Whitgift, J. Z., additional, Ishimaru, A., additional, Yaguchi, A., additional, Akiduki, N., additional, Namiki, M., additional, Takeda, M., additional, Tamminen, J. N., additional, Uusaro, A., additional, Taylor, C. G., additional, Mills, E. D., additional, Mackay, A. D., additional, Ponzoni, C., additional, Rabello, R., additional, Serpa, A., additional, Assunção, M., additional, Pardini, A., additional, Shettino, G., additional, Corrêa, T., additional, Vidal-Cortés, P. V., additional, Álvarez-Rocha, L., additional, Fernández-Ugidos, P., additional, Virgós-Pedreira, A., additional, Pérez-Veloso, M. A., additional, Suárez-Paul, I. M., additional, Del Río-Carbajo, L., additional, Fernández, S. Pita, additional, Castro-Iglesias, A., additional, Butt, A., additional, Alghabban, A. A., additional, Khurshid, S. K., additional, Ali, Z. A., additional, Nizami, I. N., additional, Salahuddin, N. S., additional, Alshahrani, M., additional, Alsubaie, A. W., additional, Alshamsy, A. S., additional, Alkhiliwi, B. A., additional, Alshammari, H. K., additional, Alshammari, M. B., additional, Telmesani, N. K., additional, Alshammari, R. B., additional, Asonto, L. P., additional, Damiani, L. P., additional, Bozza, F, additional, El Khattate, A., additional, Bizrane, M., additional, Madani, N., additional, Belayachi, J., additional, Abouqal, R., additional, Ramnarain, D., additional, Gouw-Donders, B., additional, Benstoem, C., additional, Moza, A., additional, Meybohm, P., additional, Stoppe, C., additional, Autschbach, R., additional, Devane, D., additional, Goetzenich, A., additional, Taniguchi, L. U., additional, Araujo, L., additional, Salgado, G., additional, Vieira, J. M., additional, Viana, J., additional, Ziviani, N., additional, Pessach, I., additional, Lipsky, A., additional, Nimrod, A., additional, O´Connor, M., additional, Matot, I., additional, Segal, E., additional, Kluzik, A., additional, Gradys, A., additional, Smuszkiewicz, P., additional, Trojanowska, I., additional, Cybulski, M., additional, De Jong, A., additional, Sebbane, M., additional, Chanques, G., additional, Jaber, S., additional, Rosa, R., additional, Robinson, C., additional, Bessel, M., additional, Cavalheiro, L., additional, Madeira, L., additional, Rutzen, W., additional, Oliveira, R., additional, Maccari, J., additional, Falavigna, M., additional, Sanchez, E., additional, Dutra, F., additional, Dietrich, C., additional, Balzano, P., additional, Rezende, J., additional, Teixeira, C., additional, Sinha, S., additional, Majhi, K., additional, Gorlicki, J. G., additional, Pousset, F. P., additional, Kelly, J., additional, Aron, J., additional, Gilbert, A. Crerar, additional, Urankar, N. Prevec, additional, Irazabal, M., additional, Bosque, M., additional, Manciño, J., additional, Kotsopoulos, A., additional, Jansen, N., additional, Abdo, W., additional, Casey, Ú. M., additional, O’Brien, B., additional, Plant, R., additional, and Doyle, B., additional

Published
2017
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17. An Amperometric Biosensor for the Determination of Lactic Acid During Malolactic Fermentation

Author

Sannini A., Albanese D., Malvano F., Crescitelli A., and Di Matteo M.

Subjects
amperometric biosensor, lcsh:Computer engineering. Computer hardware, food and beverages, lcsh:TP155-156, lcsh:TK7885-7895, lcsh:Chemical engineering
Abstract

A lactate oxidase amperometric biosensor was developed and optimized for the malolactic fermentation monitoring during winemaking process. Lactate oxidase enzyme was immobilized on prussian blue modified screen-printed carbon electrode in order to reduce the electrochemical interferences due to the high content of electroactive compounds abundant in wine and must, such as polyphenols and ascorbic acid. The lactate oxidase biosensor developed showed high sensitivity (852 ?A M-1) and a detection limit for lactic acid of 0.005 mM (0.45 mg L-1) The operational stability and the life time of the biosensors were also evaluated equal to 8 h and 30 days respectively. Finally the biosensor in flow injection system was used for lactic acid analysis during malolactic fermentation of a red wine and the results were compared with those registered by ion chromatography with good agreement with two sets of data.

Published
2015
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18. MR-enterography with diffusion weighted imaging: ADC values in normal and pathological bowel loops, a possible threshold ADC value to differentiate active from inactive Crohn's disease

Author

Ninivaggi, V, Missere, M, Restaino, G, Gangemi, E, Di Matteo, M, Pierro, A, Sallustio, G, Bonomo, L, Sallustio, G (ORCID:0000-0002-6641-4914), Bonomo, L (ORCID:0000-0001-5101-9367), Ninivaggi, V, Missere, M, Restaino, G, Gangemi, E, Di Matteo, M, Pierro, A, Sallustio, G, Bonomo, L, Sallustio, G (ORCID:0000-0002-6641-4914), and Bonomo, L (ORCID:0000-0001-5101-9367)

Abstract

OBJECTIVE: The aim of our study was to compare the apparent diffusion coefficient (ADC) values of pathological bowel loops wall (pADC) with the ADC values of normal appearing ones (naADC) and to determine a discriminating threshold.PATIENTS AND METHODS: 60 patients were studied at our Institution through a MR-enterography that included free-breathing axial Diffusion Weighted Imaging (DWI) with two b (0 and 800 s/mm2) after histological diagnosis of active Crohn's disease (CD). The one (when unique) or the best analyzable (when multiple) pathological bowel loop was identified in each patient, on the basis of the MRI features: wall thickness, presence of mural oedema and wall contrast enhancement after contrast medium administration. A normal appearing bowel loop was used for comparison. ADC values were measured in consensus by two radiologists, and they were compared with t-test. The ADC threshold value for the differentiation between pathological and normal appearing bowel loops was determined.RESULTS: The pADC values were significantly lower than the naADC values (1.48 +/- 0.058 x 10(-3) mm(2)/s versus 3.525 +/- 0.07 x 10(-3) mm(2)/s; p < 0.05). A threshold of 2.416 x 10(-3) mm(2)/s showed 100% sensitivity and 100% specificity for the discrimination between normal and pathological bowel loops.CONCLUSIONS: In patients with active CD the ADC values of the pathological bowel wall are significantly lower than those of normal appearing bowel loops. A threshold of ADC value of 2.416 10(-3) mm(2)/s could discriminate normal from pathological bowel loops.

Published
2016

19. Role of the Apparent Diffusion Coefficient in the Prediction of Response to Neoadjuvant Chemotherapy in Patients with Locally Advanced Breast Cancer

Author

Bufi, Enida, Belli, Paolo, Costantini, Melania, Cipriani, A., Di Matteo, M., Bonatesta, A., Franceschini, Gianluca, Terribile, Daniela Andreina, Mule, A., Nardone, L., Bonomo, Lorenzo, Bufi E., Belli P. (ORCID:0000-0001-7979-2466), Costantini M., Franceschini G. (ORCID:0000-0002-2950-3395), Terribile D. (ORCID:0000-0002-3511-0010), Bonomo L. (ORCID:0000-0001-5101-9367), Bufi, Enida, Belli, Paolo, Costantini, Melania, Cipriani, A., Di Matteo, M., Bonatesta, A., Franceschini, Gianluca, Terribile, Daniela Andreina, Mule, A., Nardone, L., Bonomo, Lorenzo, Bufi E., Belli P. (ORCID:0000-0001-7979-2466), Costantini M., Franceschini G. (ORCID:0000-0002-2950-3395), Terribile D. (ORCID:0000-0002-3511-0010), and Bonomo L. (ORCID:0000-0001-5101-9367)

Abstract

Background We evaluated the diagnostic performance of the baseline diffusion weighted imaging (DWI) and the apparent diffusion coefficient (ADC) in the prediction of a complete pathologic response (pCR) to neoadjuvant chemotherapy (NAC) in patients with breast cancer stratified according to the tumor phenotype. Patients and Methods We retrospectively studied 225 patients with stage II, III, and IV breast cancer who had undergone contrast-enhanced magnetic resonance imaging (MRI) and DWI before and after NAC, followed by breast surgery. Results The tumor phenotypes were luminal (n = 143; 63.6%), triple-negative (TN) (n = 37; 16.4%), human epidermal growth factor receptor 2 (HER2)-enriched (n = 17; 7.6%), and hybrid (hormone receptor-positive/HER2+; n = 28; 12.4%). After NAC, a pCR was observed in 39 patients (17.3%). No statistically significant difference was observed in the mean ADC value between a pCR and no pCR in the general population (1.132 ± 0.191 × 10-3 mm2/s vs. 1.092 ± 0.189 × 10-3 mm2/s, respectively; P =.23). The optimal ADC cutoff value in the general population was 0.975 × 10-3 mm2/s (receiver operating characteristic [ROC] area under the curve [AUC], 0.587 for the prediction of a pCR). After splitting the population into subgroups according to tumor phenotype, we observed a significant or nearly significant difference in the mean ADC value among the responders versus the nonresponders in the TN (P =.06) and HER2+ subgroups (P =.05). No meaningful difference was seen in the luminal and hybrid subgroups (P =.59 and P =.53, respectively). In contrast, in the TN and HER2+ subgroups (cutoff value, 0.995 × 10-3 mm2/s and 0.971 × 10-3 mm2/s, respectively), we observed adequate ROC AUCs (0.766 and 0.813, respectively). Conclusion The pretreatment ADC value is not capable of predicting the pCR in the overall population of patients with locally advanced breast cancer. Nonetheless, an ameliorated diagnostic performance was observed in specific phenotype subgroup

Published
2015

23. Effect of breast cancer phenotype on diagnostic performance of MRI in the prediction to response to neoadjuvant treatment.

Author

Bufi, E, Belli, Paolo, Di Matteo, M, Terribile, Daniela Andreina, Franceschini, Gianluca, Nardone, L, Petrone, G, Bonomo, L., Belli, Paolo (ORCID:0000-0001-7979-2466), Terribile, D (ORCID:0000-0002-3511-0010), Franceschini, Gianluca (ORCID:0000-0002-2950-3395), Bufi, E, Belli, Paolo, Di Matteo, M, Terribile, Daniela Andreina, Franceschini, Gianluca, Nardone, L, Petrone, G, Bonomo, L., Belli, Paolo (ORCID:0000-0001-7979-2466), Terribile, D (ORCID:0000-0002-3511-0010), and Franceschini, Gianluca (ORCID:0000-0002-2950-3395)

Abstract

AIM: The estimation of response to neoadjuvant chemotherapy (NAC) is useful in the surgical decision in breast cancer. We addressed the diagnostic reliability of conventional MRI, of diffusion weighted imaging (DWI) and of a merged criterion coupling morphological MRI and DWI. Diagnostic performance was analysed separately in different tumor subtypes, including HER2+ (human epidermal growth factor receptor 2)/HR+ (hormone receptor) (hybrid phenotype). MATERIALS AND METHODS: Two-hundred and twenty-five patients underwent MRI before and after NAC. The response to treatment was defined according to the RECIST classification and the evaluation of DWI with apparent diffusion coefficient (ADC). The complete pathological response - pCR was assessed (Mandard classification). RESULTS: Tumor phenotypes were Luminal (63.6%), Triple Negative (16.4%), HER2+ (7.6%) or Hybrid (12.4%). After NAC, pCR was observed in 17.3% of cases. Average ADC was statistically higher after NAC (p<0.001) among patients showing pCR vs. those who had not pCR. The RECIST classification showed adequate performance in predicting the pCR in Triple Negative (area under the receiver operating characteristic curve, ROC AUC=0.9) and in the HER2+ subgroup (AUC=0.826). Lower performance was found in the Luminal and Hybrid subgroups (AUC 0.693 and 0.611, respectively), where the ADC criterion yielded an improved performance (AUC=0.787 and 0.722). The coupling of morphological and DWI criteria yielded maximally improved performance in the Luminal and Hybrid subgroups (AUC=0.797 and 0.761). CONCLUSION: The diagnostic reliability of MRI in predicting the pCR to NAC depends on the tumor phenotype, particularly in the Luminal and Hybrid subgroups. In these cases, the coupling of morphological MRI evaluation and DWI assessment may facilitate the diagnosis.

Published
2014

24. Preface

Author

DI MATTEO, M. and Piacentini, Paolo Mario

Published
2003

25. La città come organismo : lettura di Trani alle diverse scale

Author

Strappa, Giuseppe, Ieva, M., and DI MATTEO, M. A.

Subjects
tessuto urbano, Tipologia, organismo architettonico, tessuto urbano, territorio, architettura, percorsi, morfologia, Tipologia, processo formativo, Città, organismo, Trani, tipologia, tessuti, organismo architettonico, territorio
Published
2003

26. MRI evaluation of neoadjuvant low-dose fractionated radiotherapy with concurrent chemotherapy in patients with locally advanced breast cancer

Author

Bufi, Enida, Belli, Paolo, Costantini, Melania, Rinaldi, Pierluigi, Di Matteo, M, Bonatesta, Angelo, De Santis, C, Nardone, Luigia, Terribile, Daniela Andreina, Mulé, A, Bonomo, Lorenzo, Belli, Paolo (ORCID:0000-0001-7979-2466), Terribile, Daniela Andreina (ORCID:0000-0002-3511-0010), Bonomo, Lorenzo (ORCID:0000-0001-5101-9367), Bufi, Enida, Belli, Paolo, Costantini, Melania, Rinaldi, Pierluigi, Di Matteo, M, Bonatesta, Angelo, De Santis, C, Nardone, Luigia, Terribile, Daniela Andreina, Mulé, A, Bonomo, Lorenzo, Belli, Paolo (ORCID:0000-0001-7979-2466), Terribile, Daniela Andreina (ORCID:0000-0002-3511-0010), and Bonomo, Lorenzo (ORCID:0000-0001-5101-9367)

Abstract

Objectives: We address the diagnostic performance of breast MRI and the efficacy of neoadjuvant radiochemotherapy treatment (NRC protocol) vs conventional neoadjuvant chemotherapy (NAC) in patients with locally advanced breast cancer.Methods: The NRC protocol consists of six anthracycline/taxane cycles and concomitant low-dose radiotherapy on breast tumour volume. Breast MRI was performed at baseline and after the last therapy cycle in 18 vs 36 patients undergoing the NRC protocol orObjectives: We address the diagnostic performance of breast MRI and the efficacy of neoadjuvant radiochemotherapy treatment (NRC protocol) vs conventional neoadjuvant chemotherapy (NAC) in patients with locally advanced breast cancer.Methods: The NRC protocol consists of six anthracycline/taxane cycles and concomitant low-dose radiotherapy on breast tumour volume. Breast MRI was performed at baseline and after the last therapy cycle in 18 vs 36 patients undergoing the NRC protocol or conventional NAC (propensity matching).Results: In both groups, we observed reduced tumour dimension after the last cycle (p < 0.001), and the Response Evaluation Criteria in Solid Tumours (RECIST) class directly correlated with the tumour regression grade (TRG) class after the last cycle (p < 0.001). Patients in the NRC group displayed a higher frequency of complete/partial response vs NAC (p = 0.034). 17 out of 18 patients in the NRC group met the criteria for avoiding mastectomy based on final MRI evaluation. The RECIST classification displayed a superior diagnostic performance in the prediction of the response to treatment [area under the receiver operating characteristic curve (AUC) = 0.72] vs time-to-intensity curves and ADC (AUC 0.63 and 0.61). The association of the three above criteria yielded a better diagnostic performance, both in the general population (AUC = 0.79) and in the NRC vs the NAC group separately (AUC = 0.82 and AUC = 0.76).Conclusions: The pathological response is predicted by

Published
2012

27. Relative prices and technical change: A suggested approach to long waves

Author

Vasko, Tibor, Di Matteo, M., Vasko, Tibor, and Di Matteo, M.

Abstract

Over the last decade there has been an increasingly widespread feeling that conventional static economic theory is unable to offer a convincing analysis of the evolution of economic systems and reliable proposals for remedies to the situation of stagflation. As a consequence, in the last five or six years there has been renewed interest in the analysis of long waves described by Kondratieff (1926, 1928), which were consigned to oblivion after World War II. As early as 1913 Pareto wrote a paper, taking France as an example, which sketched very clearly the argument that the world economy was characterized by long-term oscillations. The idea was that a study of long-term tendencies, or the forces and mechanisms that shape and govern them, would help in answering in a more satisfactory way the questions posed by the real world.

Published
1987

28. Technology, structural change and long-term fluctuations

Author

Di Matteo, M., Goodwin, R.M., Vercelli, A., Vasko, T., Di Matteo, M., Goodwin, R.M., Vercelli, A., and Vasko, T.

Abstract

Coming from an applied institute with a certain methodological orientation, and being innovation biased, due to my past interests, I will attempt to base my brief contribution on the relevance of some of the views and questions that have arisen in innovation research and in the course of the activities of our collaborators to the issues of long-term fluctuations in economic growth. The applied character of our institute has both advantages and disadvantages, particularly in connection with the topics of the Workshop, since we can not avoid also being, at least in part, future oriented, which is not always a rewarding exercise.

Published
1989

29. MR-enterography with diffusion weighted imaging: ADC values in normal and pathological bowel loops, a possible threshold ADC value to differentiate active from inactive Crohn's disease

Author

Ninivaggi, V., Missere, M., Gennaro Restaino, Gangemi, E., Di Matteo, M., Pierro, A., Sallustio, G., and Bonomo, L.

Subjects
Intestines, Diffusion Magnetic Resonance Imaging, Crohn Disease, N/A, Humans, Magnetic Resonance Imaging, Sensitivity and Specificity, Settore MED/36 - DIAGNOSTICA PER IMMAGINI E RADIOTERAPIA
Abstract

The aim of our study was to compare the apparent diffusion coefficient (ADC) values of pathological bowel loops wall (pADC) with the ADC values of normal appearing ones (naADC) and to determine a discriminating threshold.60 patients were studied at our Institution through a MR-enterography that included free-breathing axial Diffusion Weighted Imaging (DWI) with two b (0 and 800 s/mm2) after histological diagnosis of active Crohn's disease (CD). The one (when unique) or the best analyzable (when multiple) pathological bowel loop was identified in each patient, on the basis of the MRI features: wall thickness, presence of mural oedema and wall contrast enhancement after contrast medium administration. A normal appearing bowel loop was used for comparison. ADC values were measured in consensus by two radiologists, and they were compared with t-test. The ADC threshold value for the differentiation between pathological and normal appearing bowel loops was determined.The pADC values were significantly lower than the naADC values (1.48 ± 0.058 x 10-3 mm2/s versus 3.525 ± 0.07 x 10-3 mm2/s; p0.05). A threshold of 2.416 x 10-3 mm2/s showed 100% sensitivity and 100% specificity for the discrimination between normal and pathological bowel loops.In patients with active CD the ADC values of the pathological bowel wall are significantly lower than those of normal appearing bowel loops. A threshold of ADC value of 2.416 10-3 mm2/s could discriminate normal from pathological bowel loops.

30. 37th International Symposium on Intensive Care and Emergency Medicine (part 2 of 3)

Author

Rob, D., Špunda, R., Lindner, J., Šmalcová, J., Šmíd, O., Kovárník, T., Linhart, A., Bìlohlávek, J., Marinoni, M. M., Cianchi, G., Trapani, S., Migliaccio, M. L., Gucci, L., Bonizzoli, M., Cramaro, A., Cozzolino, M., Valente, S., Peris, A., Grins, E., Kort, E., Weiland, M., Shresta, N. Manandhar, Davidson, P., Algotsson, L., Fitch, S., Marco, G., Sturgill, J., Lee, S., Dickinson, M., Boeve, T., Khaghani, A., Wilton, P., Jovinge, S., Ahmad, A. N., Loveridge, R., Vlachos, S., Patel, S., Gelandt, E., Morgan, L., Butt, S., Whitehorne, M., Kakar, V., Park, C., Hayes, M., Willars, C., Hurst, T., Best, T., Vercueil, A., Auzinger, G., Adibelli, B., Akovali, N., Torgay, A., Zeyneloglu, P., Pirat, A., Kayhan, Z., Schmidbauer, S. S., Herlitz, J., Karlsson, T., Friberg, H., Knafelj, R., Radsel, P., Duprez, F., Bonus, T., Cuvelier, G., Mashayekhi, S., Maka, M., Ollieuz, S., Reychler, G., Mosaddegh, R., Abbasi, S., Talaee, S., Zotzmann, V. Z., Staudacher, D. S., Wengenmayer, T. W., Dürschmied, D. D., Bode, C. B., Nelskylä, A., Nurmi, J., Jousi, M., Schramko, A., Mervaala, E., Ristagno, G., Skrifvars, M., Ozsoy, G., Kendirli, T., Azapagasi, E., Perk, O., Gadirova, U., Ozcinar, E., Cakici, M., Baran, C., Durdu, S., Uysalel, A., Dogan, M., Ramoglu, M., Ucar, T., Tutar, E., Atalay, S., Akar, R., Kamps, M., Leeuwerink, G., Hofmeijer, J., Hoiting, O., Van der Hoeven, J., Hoedemaekers, C., Konkayev, A., Kuklin, V., Kondratyev, T., Konkayeva, M., Akhatov, N., Sovershaev, M., Tveita, T., Dahl, V., Wihersaari, L., Skrifvars, M. B., Bendel, S., Kaukonen, K. M., Vaahersalo, J., Romppanen, J., Pettilä, V., Reinikainen, M., Lybeck, A., Cronberg, T., Nielsen, N., Rauber, M., Steblovnik, K., Jazbec, A., Noc, M., Kalasbail, P., Garrett, F., Kulstad, E., Bergström, D. J., Olsson, H. R., Schmidbauer, S., Mandel, I., Mikheev, S., Podoxenov, Y., Suhodolo, I., Podoxenov, A., Svirko, J., Sementsov, A., Maslov, L., Shipulin, V., Vammen, L. V., Rahbek, S. R., Secher, N. S., Povlsen, J. P., Jessen, N. J., Løfgren, B. L., Granfeldt, A. G., Grossestreuer, A., Perman, S., Patel, P., Ganley, S., Portmann, J., Cocchi, M., Donnino, M., Nassar, Y., Fathy, S., Gaber, A., Mokhtar, S., Chia, Y. C., Lewis-Cuthbertson, R., Mustafa, K., Sabra, A., Evans, A., Bennett, P., Eertmans, W., Genbrugge, C., Boer, W., Dens, J., De Deyne, C., Jans, F., Skorko, A., Thomas, M., Casadio, M., Coppo, A., Vargiolu, A., Villa, J., Rota, M., Avalli, L., Citerio, G., Moon, J. B., Cho, J. H., Park, C. W., Ohk, T. G., Shin, M. C., Won, M. H., Papamichalis, P., Zisopoulou, V., Dardiotis, E., Karagiannis, S., Papadopoulos, D., Zafeiridis, T., Babalis, D., Skoura, A., Staikos, I., Komnos, A., Passos, S. Silva, Maeda, F., Souza, L. Silva, Filho, A. Amato, Granjeia, T. Araújo Guerra, Schweller, M., Franci, D., De Carvalho Filho, M., Santos, T. Martins, De Azevedo, P., Wall, R., Welters, I., Tansuwannarat, P., Sanguanwit, P., Langer, T., Carbonara, M., Caccioppola, A., Fusarini, C. Ferraris, Carlesso, E., Paradiso, E., Battistini, M., Cattaneo, E., Zadek, F., Maiavacca, R., Stocchetti, N., Pesenti, A., Ramos, A., Acharta, F., Toledo, J., Perezlindo, M., Lovesio, L., Dogliotti, A., Lovesio, C., Schroten, N., Van der Veen, B., De Vries, M. C., Veenstra, J., Abulhasan, Y. B., Rachel, S., Châtillon-Angle, M., Alabdulraheem, N., Schiller, I., Dendukuri, N., Angle, M., Frenette, C., Lahiri, S., Schlick, K., Mayer, S. A., Lyden, P., Akatsuka, M., Arakawa, J., Yamakage, M., Rubio, J., Mateo-Sidron, J. A. Rubio, Sierra, R., Celaya, M., Benitez, L., Alvarez-Ossorio, S., Fernandez, A., Gonzalez, O., Engquist, H., Rostami, E., Enblad, P., Canullo, L., Nallino, J., Perreault, M., Talic, J., Frenette, A. J., Burry, L., Bernard, F., Williamson, D. R., Adukauskiene, D., Cyziute, J., Adukauskaite, A., Malciene, L., Luca, L., Rogobete, A., Bedreag, O., Papurica, M., Sarandan, M., Cradigati, C., Popovici, S., Vernic, C., Sandesc, D., Avakov, V., Shakhova, I., Trimmel, H., Majdan, M., Herzer, G. H., Sokoloff, C. S., Albert, M., Williamson, D., Odier, C., Giguère, J., Charbonney, E., Husti, Z., Kaptás, T., Fülep, Z., Gaál, Z., Tusa, M., Donnelly, J., Aries, M., Czosnyka, M., Robba, C., Liu, M., Ercole, A., Menon, D., Hutchinson, P., Smielewski, P., López, R., Graf, J., Montes, J. M., Kenawi, M., Kandil, A., Husein, K., Samir, A., Heijneman, J., Huijben, J., Abid-Ali, F., Stolk, M., Van Bommel, J., Lingsma, H., Van der Jagt, M., Cihlar, R. C., Mancino, G., Bertini, P., Forfori, F., Guarracino, F., Pavelescu, D., Grintescu, I., Mirea, L., Alamri, S., Tharwat, M., Kono, N., Okamoto, H., Uchino, H., Ikegami, T., Fukuoka, T., Simoes, M., Trigo, E., Coutinho, P., Pimentel, J., Franci, A., Basagni, D., Boddi, M., Anichini, V., Cecchi, A., Markopoulou, D., Venetsanou, K., Papanikolaou, I., Barkouri, T., Chroni, D., Alamanos, I., Cingolani, E., Bocci, M. G., Pisapia, L., Tersali, A., Cutuli, S. L., Fiore, V., Palma, A., Nardi, G., Antonelli, M., Coke, R., Kwong, A., Dwivedi, D. J., Xu, M., McDonald, E., Marshall, J. C., Fox-Robichaud, A. E., Liaw, P. C., Kuchynska, I., Malysh, I. R., Zgrzheblovska, L. V., Mestdagh, L., Verhoeven, E. F., Hubloue, I., Ruel-laliberte, J., Zarychanski, R., Lauzier, F., Bonaventure, P. Lessard, Green, R., Griesdale, D., Fowler, R., Kramer, A., Zygun, D., Walsh, T., Stanworth, S., Léger, C., Turgeon, A. F., Baron, D. M., Baron-Stefaniak, J., Leitner, G. C., Ullrich, R., Tarabrin, O., Mazurenko, A., Potapchuk, Y., Sazhyn, D., Tarabrin, P., Pérez, A. González, Silva, J., Artemenko, V., Bugaev, A., Tokar, I., Konashevskaya, S., Kolesnikova, I. M., Roitman, E. V., Kiss, T. Rengeiné, Máthé, Z., Piros, L., Dinya, E., Tihanyi, E., Smudla, A., Fazakas, J., Ubbink, R., Boekhorst te, P., Mik, E., Caneva, L., Ticozzelli, G., Pirrelli, S., Passador, D., Riccardi, F., Ferrari, F., Roldi, E. M., Di Matteo, M., Bianchi, I., Iotti, G. A., Zurauskaite, G., Voegeli, A., Meier, M., Koch, D., Haubitz, S., Kutz, A., Bargetzi, M., Mueller, B., Schuetz, P., Von Meijenfeldt, G., Van der Laan, M., Zeebregts, C., Christopher, K. B., Vernikos, P., Melissopoulou, T., Kanellopoulou, G., Panoutsopoulou, M., Xanthis, D., Kolovou, K., Kypraiou, T., Floros, J., Broady, H., Pritchett, C., Marshman, M., Jannaway, N., Ralph, C., Lehane, C. L., Keyl, C. K., Zimmer, E. Z., Trenk, D. T., Ducloy-Bouthors, A. S., Jonard, M. J., Fourrier, F., Piza, F., Correa, T., Marra, A., Guerra, J., Rodrigues, R., Vilarinho, A., Aranda, V., Shiramizo, S., Lima, M. R., Kallas, E., Cavalcanti, A. B., Donoso, M., Vargas, P., McCartney, J., Ramsay, S., McDowall, K., Novitzky-Basso, I., Wright, C., Medic, M Grgic, Bielen, L, Radonic, V, Zlopasa, O, Vrdoljak, N Gubarev, Gasparovic, V, Radonic, R, Narváez, G., Cabestrero, D., Rey, L., Aroca, M., Gallego, S., Higuera, J., De Pablo, R., González, L. Rey, Chávez, G. Narváez, Lucas, J. Higuera, Alonso, D. Cabestrero, Ruiz, M. Aroca, Valarezo, L. Jaramillo, De Pablo Sánchez, R., Real, A. Quinza, Wigmore, T. W., Bendavid, I., Cohen, J., Avisar, I., Serov, I., Kagan, I., Singer, P., Hanison, J, Mirza, U, Conway, D, Takasu, A., Tanaka, H., Otani, N., Ohde, S., Ishimatsu, S., Coffey, F, Dissmann, P, Mirza, K, Lomax, M, Dissmann, P., Coffey, F., Mirza, K., Lomax, M., Miner, JR, Leto, R, Markota, AM, Gradišek, PG, Aleksejev, VA, Sinkovič, AS, Romagnoli, S., Chelazzi, C., Zagli, G., Benvenuti, F., Mancinelli, P., Boninsegni, P., Paparella, L., Bos, A. T., Thomas, O., Goslar, T., Martone, A., Sandu, P. R., Rosu, V. A., Capilnean, A., Murgoi, P., Lecavalier, A., Jayaraman, D., Rico, P., Bellemare, P., Gelinas, C., Nishida, T., Kinoshita, T., Iwata, N., Yamakawa, K., Fujimi, S., Maggi, L., Sposato, F., Citterio, G., Bonarrigo, C., Rocco, M., Zani, V., De Blasi, R. A., Alcorn, D, Barry, L, Riedijk, M. A., Milstein, D. M., Caldas, J., Panerai, R., Camara, L., Ferreira, G., Bor-Seng-Shu, E., Lima, M., Galas, F., Mian, N., Nogueira, R., de Oliveira, G. Queiroz, Almeida, J., Jardim, J., Robinson, T. G., Gaioto, F., Hajjar, L. A., Zabolotskikh, I., Musaeva, T., Saasouh, W., Freeman, J., Turan, A., Saseedharan, S., Pathrose, E., Poojary, S., Messika, J., Martin, Y., Maquigneau, N., Henry-Lagarrigue, M., Puechberty, C., Stoclin, A., Martin-Lefevre, L., Blot, F., Dreyfuss, D., Dechanet, A., Hajage, D., Ricard, J., Almeida, E., Landoni, G., Fukushima, J., Fominskiy, E., De Brito, C., Cavichio, L., Almeida, L., Ribeiro, U., Osawa, E., Boltes, R., Battistella, L., Hajjar, L., Fontela, P., Lisboa, T., Junior, L. Forgiarini, Friedman, G. F., Abruzzi, F., Primo, J. Azevedo Peixoto, Filho, P. Marques, de Andrade, J. Stormorvski, Brenner, K. Matos, boeira, M. Scorsato, Leães, C., Rodrigues, C., Vessozi, A., Machado, A. SantAnna, Weiler, M., Bryce, H., Hudson, A., Law, T., Reece-Anthony, R., Molokhia, A., Abtahinezhadmoghaddam, F., Cumber, E., Channon, L., Wong, A., Groome, R., Gearon, D., Varley, J., Wilson, A., Reading, J., Zampieri, F. G., Bozza, F. A., Ferez, M., Fernandes, H., Japiassú, A., Verdeal, J., Carvalho, A. C., Knibel, M., Salluh, J. I., Soares, M., Gao, J., Ahmadnia, E., Patel, B., MacKay, A., Binning, S., Pugh, R. J., Battle, C., Hancock, C., Harrison, W., Szakmany, T., Mulders, F., Vandenbrande, J., Dubois, J., Stessel, B., Siborgs, K., Ramaekers, D., Silva, U. V., Homena, W. S., Fernandes, G. C., Moraes, A. P., Brauer, L., Lima, M. F., De Marco, F., Maric, N., Mackovic, M., Udiljak, N., Bosso, CE, Caetano, RD, Cardoso, AP, Souza, OA, Pena, R, Mescolotte, MM, Souza, IA, Mescolotte, GM, Bangalore, H., Borrows, E., Barnes, D., Ferreira, V., Azevedo, L., Alencar, G., Andrade, A., Bierrenbach, A., Buoninsegni, L. Tadini, Cecci, L., Lindskog, J., Rowland, K., Sturgess, P., Ankuli, A., Rosa, R, Tonietto, T, Ascoli, A, Madeira, L, Rutzen, W, Falavigna, M, Robinson, C, Salluh, J, Cavalcanti, A, Azevedo, L, Cremonese, R, Da Silva, D, Dornelles, A, Skrobik, Y, Teles, J, Ribeiro, T, Eugênio, C, Teixeira, C, Zarei, M., Hashemizadeh, H., Eriksson, M., Strandberg, G., Lipcsey, M., Larsson, A., Lignos, M., Crissanthopoulou, E., Flevari, K., Dimopoulos, P., Armaganidis, A., Golub, JG, Stožer, AS, Rüddel, H., Ehrlich, C., Burghold, C. M., Hohenstein, C., Winning, J., Sellami, W., Hajjej, Z., Bousselmi, M., Gharsallah, H., Labbene, I., Ferjani, M., Sattler, J., Steinbrunner, D., Poppert, H., Schneider, G., Blobner, M., Kanz, K. G., Schaller, S. J., Apap, K., Xuereb, G., Massa, L., Delvau, N., Penaloza, A, Liistro, G, Thys, F, Delattre, I. K., Hantson, P., Roy, P. M., Gianello, P., Hadîrcă, L, Ghidirimschi, A, Catanoi, N, Scurtov, N, Bagrinovschi, M, Sohn, Y. S., Cho, Y. C., Golovin, B., Creciun, O., Ghidirimschi, A., Bagrinovschi, M., Tabbara, R., Whitgift, J. Z., Ishimaru, A., Yaguchi, A., Akiduki, N., Namiki, M., Takeda, M., Tamminen, J. N., Uusaro, A., Taylor, C. G., Mills, E. D., Mackay, A. D., Ponzoni, C., Rabello, R., Serpa, A., Assunção, M., Pardini, A., Shettino, G., Corrêa, T., Vidal-Cortés, P. V., Álvarez-Rocha, L., Fernández-Ugidos, P., Virgós-Pedreira, A., Pérez-Veloso, M. A., Suárez-Paul, I. M., Del Río-Carbajo, L., Fernández, S. Pita, Castro-Iglesias, A., Butt, A., Alghabban, A. A., Khurshid, S. K., Ali, Z. A., Nizami, I. N., Salahuddin, N. S., Alshahrani, M., Alsubaie, A. W., Alshamsy, A. S., Alkhiliwi, B. A., Alshammari, H. K., Alshammari, M. B., Telmesani, N. K., Alshammari, R. B., Asonto, L. P., Damiani, L. P., Bozza, F, El Khattate, A., Bizrane, M., Madani, N., Belayachi, J., Abouqal, R., Ramnarain, D., Gouw-Donders, B., Benstoem, C., Moza, A., Meybohm, P., Stoppe, C., Autschbach, R., Devane, D., Goetzenich, A., Taniguchi, L. U., Araujo, L., Salgado, G., Vieira, J. M., Viana, J., Ziviani, N., Pessach, I., Lipsky, A., Nimrod, A., O´Connor, M., Matot, I., Segal, E., Kluzik, A., Gradys, A., Smuszkiewicz, P., Trojanowska, I., Cybulski, M., De Jong, A., Sebbane, M., Chanques, G., Jaber, S., Rosa, R., Robinson, C., Bessel, M., Cavalheiro, L., Madeira, L., Rutzen, W., Oliveira, R., Maccari, J., Falavigna, M., Sanchez, E., Dutra, F., Dietrich, C., Balzano, P., Rezende, J., Teixeira, C., Sinha, S., Majhi, K., Gorlicki, J. G., Pousset, F. P., Kelly, J., Aron, J., Gilbert, A. Crerar, Urankar, N. Prevec, Irazabal, M., Bosque, M., Manciño, J., Kotsopoulos, A., Jansen, N., Abdo, W., Casey, Ú. M., O’Brien, B., Plant, R., and Doyle, B.

Subjects
Critical Care and Intensive Care Medicine, Meeting Abstracts
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31. Coagulopathy and COVID-19

Author

Paolo Gritti, Ferdinando Luca Lorini, Fabrizio Fabretti, Maria di Matteo, Lucia Zacchetti, Luca Longhi, Lorenzo Grazioli, Isabella Maria Bianchi, Alberto Benigni, Lorini, F, Di Matteo, M, Gritti, P, Grazioli, L, Benigni, A, Zacchetti, L, Bianchi, I, Fabretti, F, and Longhi, L

Subjects
Disseminated intravascular coagulation, business.industry, medicine.drug_class, immunothrombosi, Anticoagulant, immunothrombosis, COVID-19, Articles, Heparin, Fibrinogen, medicine.disease, Coagulopathy, D-dimer, Immunology, Antithrombotic, medicine, AcademicSubjects/MED00200, Endothelial dysfunction, Cardiology and Cardiovascular Medicine, business, medicine.drug
Abstract

SARS-CoV-2 infection is associated with frequent thrombotic events, at the micro and macro-vascular level, due to the perpetuation of a state of hypercoagulability. The so-called ‘COVID-19 associated coagulopathy’ (CAC) represents a key aspect in the genesis of organ damage from SARS-CoV-2. The main coagulative alterations described in the literature are represented by high levels of D-dimer and fibrinogen. Although CAC has some common features with disseminated intravascular coagulation and sepsis-induced coagulopathy, there are important differences between these clinical pictures and the phenotype of CAC is unique. The pathogenesis of CAC is complex and is affected by the strong interconnection between the inflammatory system and coagulation, in the phenomenon of immunothrombosis and thrombo-inflammation. Several mechanisms come into play, such as inflammatory cytokines, neutrophils, the complement system as well as an alteration of the fibrinolytic system. Finally, an altered platelet function and especially endothelial dysfunction also play a central role in the pathophysiology of CAC. Heparin has several potential effects in CAC, in fact in addition to the anticoagulant effect, it could have a direct antiviral effect and anti-inflammatory properties. The high incidence of thrombo-embolic phenomena despite the use of antithrombotic prophylaxis have led some experts to recommend the use of anticoagulant doses of heparin, but at present the optimal anticoagulant regimen remains to be determined.

Published
2021
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32. DEHYDRATION AND REHYDRATION CHARACTERISTICS OF PRETREATED PUMPKIN SLICES.

Author

ADILETTA, G., WIJERATHNE, C., SENADEERA, W., RUSSO, P., CRESCITELLI, A., and DI MATTEO, M.

Subjects
*DEHYDRATION, *PLANT physiology, *PUMPKINS, *AMINO acids, *PLANT extracts, *PLANTS
Abstract

The influence of an alternative chemical pretreatment on dehydration and rehydration of an Italian ecotype pumpkin was investigated. The pretreatment consisted of soaking the slices in a diluted solution of trehalose, sucrose and NaCl. Hot air-drying was performed in a convective dryer at temperatures of 55, 60, 65 and 70°C. Samples treated prior to drying showed a shorter (about 1/4) drying time, less volume shrinkage and colour changes, but showed higher rehydration capacity compared to untreated ones, especially in the range 55-65°C. Moreover, the pretreatment was effective in retention of total phenolic content and antioxidant activity. The Midilli model was the most appropriate for describing drying behaviour, while the Weibull model for rehydration. [ABSTRACT FROM AUTHOR]

Published
2018

33. SQUID (SEPIA OFFICINALIS) STORED IN ACTIVE PACKAGING: SOME CHEMICAL AND MICROBIOLOGICAL CHANGES.

Author

Albanese, D., Cinquanta, L., Lanorte, M. T., and Di Matteo, M.

Subjects
*PACKAGING, *SQUIDS, *CHEMICAL reagents, *FISH spoilage, *MICROBIOLOGY
Abstract

The effect of modified atmosphere packaging (MAP) with and without a moisture adsorbent, on the quality of squid (Sepia officinalis) during chilled storage, was evaluated. Chemical and microbiological tests were carried out to measure the amount of spoilage and the resulting loss of fish freshness during 12 days of storage at 3°C. After 11 days, trimethylamine nitrogen (TMA-N) increased from 0.4 mg/100 g in fresh samples to 24 mg/100 g in MAP with adsorbent and 35 mg/100 g in the other samples. Total volatile basic nitrogen (TVB-N) increased from 18 mg/100 g in fresh samples to 112 mg/100 g in MAP with adsorbent and 158 mg/100 g in control samples. Counts of aerobic psychrotrophic microorganisms and presumptive Pseudomonads were more than 10 times lower in both MAP treatments compared to the control, in which counts exceeded 106 cfu/g on day 9, and 107 cfu/g on day 12. [ABSTRACT FROM AUTHOR]

Published
2005

34. Effect of a physical pre-treatment and drying on carotenoids of goji berries ( Lycium barbarum L.)

Author

Alessandra Fratianni, Giuseppina Adiletta, Serena Niro, M.D.R. Alam, Gianfranco Panfili, Luciano Cinquanta, M. Di Matteo, Fratianni, A., Niro, S., Alam, M. D. R., Cinquanta, L., Di Matteo, M., Adiletta, G., and Panfili, G.

Subjects
Zeaxanthin-dipalmitate, Abrasive pre-treatment, Colour, Lycium barbarum L., Thermal treatment, Zeaxanthin-dipalmitate, Colour, chemistry.chemical_compound, 0404 agricultural biotechnology, food, Abrasive pre-treatment, Dry weight, Thermal treatment, Food science, Carotenoid, chemistry.chemical_classification, Lycium barbarum L, biology, Goji berry, Food Science, food and beverages, Settore AGR/15 - Scienze E Tecnologie Alimentari, 04 agricultural and veterinary sciences, Repeatability, Abrasive pre-treatment Colour Lycium barbarum L. Thermal treatment Zeaxanthin-dipalmitate, biology.organism_classification, 040401 food science, food.food, Zeaxanthin, chemistry, Xanthophyll, Lycium, Saponification
Abstract

In order to evaluate the influence of an abrasive pre-treatment and drying at 50 °C, 60 °C, 70 °C of goji fruits (Lycium barbarum L.), changes in colour and carotenoids were studied. An extraction method was modified and adapted to assay the main carotenoid esters and saponified carotenoids of goji berries, before and after treatments. Goji berries were confirmed as a high source of zeaxanthin, with zeaxanthin-dipalmitate at about 2 g/kg dry weight. The reliability of the analytical method was confirmed by the high quantitative recoveries, about 100%, a higher repeatability than reference methods and a good reproducibility (lower than 5%). After drying, significant but small carotenoid losses (15–20%) were observed in both pre-treated and treated samples. The xanthophyll esters confirmed to be more stable than free carotenoids. The drying process significantly modified colour, in both pre-treated and untreated samples, however, pre-treatment reduced drying time and thus better preserved the colour of the goji berries for a drying temperature up to 60 °C. © 2018 Elsevier Ltd

Published
2018

35. Kinetics of carotenoids degradation and furosine formation in dried apricots (Prunus armeniaca L.)

Author

Gianfranco Panfili, M. Di Matteo, Donatella Albanese, Serena Niro, Alessandra Fratianni, Luciano Cinquanta, Maria Cristina Messia, FRATIANNI, Alessandra, NIRO, Serena, MESSIA, Maria Cristina, CINQUANTA, Luciano, PANFILI, Gianfranco, Albanese, D., and Di Matteo, M.

Subjects
Lutein, Hot Temperature, Food Handling, Prunus armeniaca, Apricot, Kinetics, Color, Thermal treatment, Activation energy, Xanthophylls, 01 natural sciences, chemistry.chemical_compound, 0404 agricultural biotechnology, Carotenoids, Drying, Furosine, Food Science, Desiccation, Carotenoid, chemistry.chemical_classification, Kinetic, Chromatography, biology, Chemistry, Lysine, 010401 analytical chemistry, 04 agricultural and veterinary sciences, Settore AGR/15 - Scienze E Tecnologie Alimentari, biology.organism_classification, 040401 food science, 0104 chemical sciences, Biochemistry, Models, Chemical, Fruit, Degradation (geology), Nutritive Value, Violaxanthin
Abstract

The kinetics of carotenoid and color degradation, as well as furosine formation, were investigated in apricot fruits during convective heating at 50, 60 and 70 °C. Degradation of carotenoids and color, expressed as total color difference (TCD), followed a first and zero order kinetic, respectively. The activation energy (Ea) for carotenoids degradation ranged from 73.7 kJ/mol for 13- cis -β-carotene to 120.7 kJ/mol for lutein, being about 91 kJ/mol for all- trans -β-carotene. Violaxanthin and anteraxanthin were the most susceptible to thermal treatment. The furosine evolution was fitted at zero order kinetic model. The Ea for furosine formation was found to be 83.3 kJ/mol and the Q 10 (temperature coefficient) varied from 1.59 to 4.14 at the temperature ranges 50–60 °C and 60–70 °C, respectively.

Published
2017

36. Economia, istituzioni ed equità soiale in Attilio da Empoli. Note su un economista-parlamentare nel regime fascista (1935-1943)

Author

BINI, Piero, Di Matteo M. e Longobardi E., and Bini, Piero

Subjects
Fascismo, Politica economica, Storia del Pensiero Economico
Abstract

Questo scritto intende ricostruire alcuni elementi del profilo scientifico e dell'impegno culturale dell'economista Attilio da Empoli, analizzando i contenuti dei suoi interventi parlamentari sulla finanza pubblica e sulla politica monetaria effettuati dal 1935 al 1939, nonchè di una sua nota critica sul tema della pianificazione

Published
2012

37. Hyperfunctional coagulation factor IX improves the efficacy of gene therapy in hemophilic mice

Author

Alessio Cantore, Janka Matrai, Marinee Chuah, Nisha Nair, Chiara Brombin, Patrizia Della Valle, Clelia Di Serio, Mario Di Matteo, Armando D'Angelo, Luigi Naldini, Francesca Sanvito, Thierry VandenDriessche, Cantore, A, Nair, N, Della Valle, P, Di Matteo, M, Màtrai, J, Sanvito, F, Brombin, Chiara, DI SERIO, Mariaclelia, D'Angelo, A, Chuah, M, Naldini, Luigi, and Vandendriessche, T.

Subjects
Genetic enhancement, Immunology, Genetic Vectors, 030204 cardiovascular system & hematology, Pharmacology, Biochemistry, Hemophilia B, Factor IX, 03 medical and health sciences, Mice, 0302 clinical medicine, Therapeutic index, Protein replacement therapy, Dogs, Hemophilias, medicine, Potency, Animals, Humans, Blood Coagulation, 030304 developmental biology, 0303 health sciences, business.industry, Lentivirus, Cell Biology, Hematology, Genetic Therapy, Coagulation Factor IX, 3. Good health, Treatment Outcome, Amino Acid Substitution, Hemostasis, Mutation, Feasibility Studies, Partial Thromboplastin Time, business, medicine.drug
Abstract

Gene therapy may provide a cure for hemophilia and overcome the limitations of protein replacement therapy. Increasing the potency of gene transfer vectors may allow improvement of their therapeutic index, as lower doses can be administered to achieve therapeutic benefit, reducing toxicity of in vivo administration. Here we generated codon-usage optimized and hyperfunctional factor IX (FIX) transgenes carrying an R338L amino acid substitution (FIX Padua), previously associated with clotting hyperactivity and thrombophilia. We delivered these transgenes to hemophilia B mice by hepatocyte-targeted integration-competent and -defective lentiviral vectors. The hyperfunctional FIX transgenes increased FIX activity reconstituted in the plasma without detectable adverse effects, allowing correction of the disease phenotype at lower vector doses and resulting in improved hemostasis in vivo. The combined effect of codon optimization with the hyperactivating FIX-R338L mutation resulted in a robust 15-fold gain in potency and therefore provides a promising strategy to improve the efficacy, feasibility, and safety of hemophilia gene therapy.

Published
2012

38. Mathematical model with shrinkage of an eggplant drying process

Author

Brasiello, Antonio, Crescitelli, Silvestro, Adiletta, Giuseppina, DI MATTEO, Marisa, Albanese, Donatella, Pierucci S., Brasiello, A., Crescitelli, Silvestro, Adiletta, G., Di Matteo, M., and Albanese, D.

Subjects
lcsh:Computer engineering. Computer hardware, shrinkage, ComputingMethodologies_DOCUMENTANDTEXTPROCESSING, lcsh:TP155-156, lcsh:TK7885-7895, food drying, mathematical model, lcsh:Chemical engineering, ComputingMilieux_MISCELLANEOUS, ComputingMethodologies_COMPUTERGRAPHICS
Abstract

preview not available - see full-text PDF article.

Published
2011

39. Experimental investigation and mathematical modeling of water absorption in air-dried chestnuts

Author

Albanese Donatella, Di Matteo Marisa, Adiletta Giuseppina, Crescitelli Silvestro, Altimari Pietro, Pierucci S., Buzzi Ferraris G., Altimari, Pietro, Adiletta, G., Albanese, D., Crescitelli, Silvestro, and Di Matteo, M.

Subjects
Water transport, Chromatography, Absorption of water, Water activity, Dried fruit, Chemistry, Sorption, chestnuts, non-fickian diffusion, rehydration, Starch gelatinization, Chemical engineering, medicine, Swelling, medicine.symptom, Diffusion (business)
Abstract

Chestnuts are characterized by limited shelf-life because of their high water activity and sugar content. For this reason, air-drying is typically performed to achieve physicochemical and microbiological stability of such fruits. However, undesired structural changes can occur during drying owing to the achievement of high processing temperature. These modifications can affect water permeability ruling out the possibility of uniformly rehydrating the dried fruit. This contribution provides an experimental and modeling study of the rehydration process of air-dried chestnuts. With the objective of characterizing the effect of the drying temperature on water permeability, chestnuts previously dried at 40, 60 and 80 °C are rehydrated by immersion in water at 90 °C and sorption curves are constructed. Under the explored processing conditions, a purely Fickian diffusion model fails to describe the evolution of the absorbed amount of water due to the occurrence of swelling and starch gelatinization. Therefore, a mathematical model is formulated simultaneously accounting for the effect of diffusion, swelling and starch gelatinization on the transport of water. Parametric estimation of the model parameters is performed, based on the results of rehydration tests, by nonlinear regression techniques. In this way, satisfactory agreement between model predictions and derived experimental data is achieved and valuable information about the influence of the drying pre-processing conditions on water transport are obtained.

Published
2010
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41. Visible light-induced ruthenium(ii)-catalyzed hydroarylation of unactivated olefins.

Author

Trienes S, Golling S, Gieuw MH, Di Matteo M, and Ackermann L

Abstract

Hydroarylation reactions have emerged as a valuable tool for the direct functionalization of C-H bonds with ideal atom economy. However, common catalytic variants for these transformations largely require harsh reaction conditions, which often translate into reduced selectivites. In contrast, we herein report on a photo-induced hydroarylation of unactivated olefins at room temperature employing a readily available ruthenium(ii) catalyst. Our findings include high position- and regio-selectivity and remarkable tolerance of a wide range of functional groups, which further enabled the late-stage diversification., Competing Interests: There are no conflicts to declare., (This journal is © The Royal Society of Chemistry.)

Published
2024
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42. Pd-Catalyzed C(sp 2 )-H/C(sp 2 )-H Coupling of Limonene.

Author

Di Matteo M, Gagliardi A, Pradal A, Veiros LF, Gallou F, and Poli G

Abstract

Limonene undergoes a regioselective Pd(II)-catalyzed C(sp 2 )-H/C(sp 2 )-H coupling with acrylic acid esters and amides, α,β-unsaturated ketones, styrenes, and allyl acetate, affording novel 1,3-dienes. DFT computations gave results in accord with the experimental results and allowed for the formulation of a plausible mechanism. The postfunctionalization of one of the coupled products was achieved via a large-scale Sonogashira reaction conducted under micellar catalysis.

Published
2024
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43. Cerebral autoregulation in traumatic brain injury: ultra-low-frequency pressure reactivity index and intracranial pressure across age groups.

Author

Gritti P, Bonfanti M, Zangari R, Bonanomi E, Farina A, Pezzetti G, Pelliccioli I, Longhi L, Di Matteo M, Viscone A, Lando G, Cavalleri G, Gerevini S, Biroli F, and Lorini FL

Subjects
Adult, Humans, Child, Algorithms, Homeostasis, Hospital Mortality, Intracranial Pressure, Brain Injuries, Traumatic
Abstract

Background: The ultra-low-frequency pressure reactivity index (UL-PRx) has been established as a surrogate method for bedside estimation of cerebral autoregulation (CA). Although this index has been shown to be a predictor of outcome in adult and pediatric patients with traumatic brain injury (TBI), a comprehensive evaluation of low sampling rate data collection (0.0033 Hz averaged over 5 min) on cerebrovascular reactivity has never been performed., Objective: To evaluate the performance and predictive power of the UL-PRx for 12-month outcome measures, alongside all International Mission for Prognosis and Analysis of Clinical Trials (IMPACT) models and in different age groups. To investigate the potential for optimal cerebral perfusion pressure (CPPopt)., Methods: Demographic data, IMPACT variables, in-hospital mortality, and Glasgow Outcome Scale Extended (GOSE) at 12 months were extracted. Filtering and processing of the time series and creation of the indices (cerebral intracranial pressure (ICP), cerebral perfusion pressure (CPP), UL-PRx, and deltaCPPopt (ΔCPPopt and CPPopt-CPP)) were performed using an in-house algorithm. Physiological parameters were assessed as follows: mean index value, % time above threshold, and mean hourly dose above threshold., Results: A total of 263 TBI patients were included: pediatric (17.5% aged ≤ 16 y) and adult (60.5% aged > 16 and < 70 y and 22.0% ≥ 70 y, respectively) patients. In-hospital and 12-month mortality were 25.9% and 32.7%, respectively, and 60.0% of patients had an unfavorable outcome at 12 months (GOSE). On univariate analysis, ICP, CPP, UL-PRx, and ΔCPPopt were associated with 12-month outcomes. The cutoff of ~ 20-22 for mean ICP and of ~ 0.30 for mean UL-PRx were confirmed in all age groups, except in patients older than 70 years. Mean UL-PRx remained significantly associated with 12-month outcomes even after adjustment for IMPACT models. This association was confirmed in all age groups. UL-PRx resulted associate with CPPopt., Conclusions: The study highlights UL-PRx as a tool for assessing CA and valuable outcome predictor for TBI patients. The results emphasize the potential clinical utility of the UL-PRx and its adaptability across different age groups, even after adjustment for IMPACT models. Furthermore, the correlation between UL-PRx and CPPopt suggests the potential for more targeted treatment strategies., Trial Registration: ClinicalTrials.gov identifier: NCT05043545, principal investigator Paolo Gritti, date of registration 2021.08.21., (© 2024. The Author(s).)

Published
2024
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44. Breast tumors interfere with endothelial TRAIL at the premetastatic niche to promote cancer cell seeding.

Author

Riera-Domingo C, Leite-Gomes E, Charatsidou I, Zhao P, Carrá G, Cappellesso F, Mourao L, De Schepper M, Liu D, Serneels J, Alameh MG, Shuvaev VV, Geukens T, Isnaldi E, Prenen H, Weissman D, Muzykantov VR, Soenen S, Desmedt C, Scheele CLGJ, Sablina A, Di Matteo M, Martín-Pérez R, and Mazzone M

Subjects
Humans, Female, Ligands, Receptors, TNF-Related Apoptosis-Inducing Ligand genetics, Receptors, TNF-Related Apoptosis-Inducing Ligand metabolism, TNF-Related Apoptosis-Inducing Ligand, Apoptosis genetics, Tumor Necrosis Factor-alpha pharmacology, Endothelial Cells metabolism, Breast Neoplasms
Abstract

Endothelial cells (ECs) grant access of disseminated cancer cells to distant organs. However, the molecular players regulating the activation of quiescent ECs at the premetastatic niche (PMN) remain elusive. Here, we find that ECs at the PMN coexpress tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and its cognate death receptor 5 (DR5). Unexpectedly, endothelial TRAIL interacts intracellularly with DR5 to prevent its signaling and preserve a quiescent vascular phenotype. In absence of endothelial TRAIL, DR5 activation induces EC death and nuclear factor κB/p38-dependent EC stickiness, compromising vascular integrity and promoting myeloid cell infiltration, breast cancer cell adhesion, and metastasis. Consistently, both down-regulation of endothelial TRAIL at the PMN by proangiogenic tumor-secreted factors and the presence of the endogenous TRAIL inhibitors decoy receptor 1 (DcR1) and DcR2 favor metastasis. This study discloses an intracrine mechanism whereby TRAIL blocks DR5 signaling in quiescent endothelia, acting as gatekeeper of the vascular barrier that is corrupted by the tumor during cancer cell dissemination.

Published
2023
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45. Autochthonous Apple Cultivars from the Campania Region (Southern Italy): Bio-Agronomic and Qualitative Traits.

Author

Cice D, Ferrara E, Magri A, Adiletta G, Capriolo G, Rega P, Di Matteo M, and Petriccione M

Abstract

Apple ( Malus × domestica Borkh.) is an important fruit crop widely spread in the cold and mild climates of temperate regions in the world, with more than 93 million tons harvested worldwide in 2021. The object of this work was to analyze thirty-one local apple cultivars of the Campania region (Southern Italy) using agronomic, morphological (UPOV descriptors) and physicochemical (solid soluble content, texture, pH and titratable acidity, skin color, Young's modulus and browning index) traits. UPOV descriptors highlighted similarities and differences among apple cultivars with a depth phenotypic characterization. Apple cultivars showed significant differences in fruit weight (31.3-236.02 g) and physicochemical trait ranging from 8.0 to 14.64° Brix for solid soluble content, 2.34-10.38 g malic acid L -1 for titratable acidity, and 15-40% for browning index. Furthermore, different percentages in apple shape and skin color have been detected. Similarities among the cultivars based on their bio-agronomic and qualitative traits have been evaluated by cluster analyses and principal component analyses. This apple germplasm collection represents an irreplaceable genetic resource with considerable morphological and pomological variabilities among several cultivars. Nowadays, some local cultivars, widespread only in restricted geographical areas, could be reintroduced in cultivation contribution to improving the diversity of our diets and contemporary to preserve knowledge on traditional agricultural systems.

Published
2023
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46. Agronomic, Physicochemical, Aromatic and Sensory Characterization of Four Sweet Cherry Accessions of the Campania Region.

Author

Magri A, Malorni L, Cozzolino R, Adiletta G, Siano F, Picariello G, Cice D, Capriolo G, Nunziata A, Di Matteo M, and Petriccione M

Abstract

Sweet cherries ( Prunus avium L.) are greatly appreciated fruits worldwide due to their taste, color, nutritional value, and beneficial health effects. The characterization of autochthonous germplasm allows to identify genotypes that possess superior characteristics compared to standard cultivars. In this work, four accessions of sweet cherry from the Campania region (Limoncella, Mulegnana Riccia, Mulegnana Nera and Montenero) were investigated for their morpho-physiological, qualitative, aromatic, and sensorial traits in comparison with two standard cultivars (Ferrovia and Lapins). A high variability in the pomological traits resulted among the samples. Montenero showed comparable fruit weight and titratable acidity to Ferrovia and Lapins, respectively. The highest total soluble solid content was detected in Mulegnana Riccia. A considerable variability in the skin and pulp color of the cherries was observed, varying from yellow-red in Limoncella to a dark red color in Montenero. Mulegnana Nera showed the highest content of polyphenols, flavonoids, anthocyanins, and ascorbic acid compared to the standard cultivars. Volatile organic compounds profile analysis identified 34 volatile compounds, 12 of which were observed at different concentrations in all the sweet cherry genotypes while the others were genotype-dependent. Conservation and cultivation of autochthonous accessions with suitable nutritional and morpho-physiologic characteristics promotes our agrobiodiversity knowledge and allows to better plan future breeding programs.

Published
2023
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47. Immunoediting instructs tumor metabolic reprogramming to support immune evasion.

Author

Tsai CH, Chuang YM, Li X, Yu YR, Tzeng SF, Teoh ST, Lindblad KE, Di Matteo M, Cheng WC, Hsueh PC, Kao KC, Imrichova H, Duan L, Gallart-Ayala H, Hsiao PW, Mazzone M, Ivanesevic J, Liu X, de Visser KE, Lujambio A, Lunt SY, Kaech SM, and Ho PC

Subjects
Humans, Interferon-gamma metabolism, T-Lymphocytes metabolism, Carcinogenesis, Cell Transformation, Neoplastic, Tumor Microenvironment, Immune Evasion, Neoplasms pathology
Abstract

Immunoediting sculpts immunogenicity and thwarts host anti-tumor responses in tumor cells during tumorigenesis; however, it remains unknown whether metabolic programming of tumor cells can be guided by immunosurveillance. Here, we report that T cell-mediated immunosurveillance in early-stage tumorigenesis instructs c-Myc upregulation and metabolic reprogramming in tumor cells. This previously unexplored tumor-immune interaction is controlled by non-canonical interferon gamma (IFNγ)-STAT3 signaling and supports tumor immune evasion. Our findings uncover that immunoediting instructs deregulated bioenergetic programs in tumor cells to empower them to disarm the T cell-mediated immunosurveillance by imposing metabolic tug-of-war between tumor and infiltrating T cells and forming the suppressive tumor microenvironment., Competing Interests: Declaration of interests P.-C.H. is a member of the scientific advisory board for Elixiron Immunotherapeutics and received research grants from Elixiron Immunotherapeutics. P.-C.H. is also a founder of Pilatus Biosciences., (Copyright © 2022 Elsevier Inc. All rights reserved.)

Published
2023
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48. Azobenzene as Antimicrobial Molecules.

Author

Di Martino M, Sessa L, Di Matteo M, Panunzi B, Piotto S, and Concilio S

Subjects
Anti-Bacterial Agents pharmacology, Anti-Infective Agents pharmacology, Azo Compounds chemistry, Azo Compounds pharmacology
Abstract

Azo molecules, characterized by the presence of a -N=N- double bond, are widely used in various fields due to their sensitivity to external stimuli, ch as light. The emergence of bacterial resistance has pushed research towards designing new antimicrobial molecules that are more efficient than those currently in use. Many authors have attempted to exploit the antimicrobial activity of azobenzene and to utilize their photoisomerization for selective control of the bioactivities of antimicrobial molecules, which is necessary for antibacterial therapy. This review will provide a systematic and consequential approach to coupling azobenzene moiety with active antimicrobial molecules and drugs, including small and large organic molecules, such as peptides. A selection of significant cutting-edge articles collected in recent years has been discussed, based on the structural pattern and antimicrobial performance, focusing especially on the photoactivity of azobenzene and the design of smart materials as the most targeted and desirable application., Competing Interests: The authors declare no conflict of interest.

Published
2022
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49. Characterization of compliance phenotypes in COVID-19 acute respiratory distress syndrome.

Author

Zacchetti L, Longhi L, Bianchi I, Di Matteo M, Russo F, Gandini L, Manesso L, Monti M, Cosentini R, Di Marco F, Fagiuoli S, Grazioli L, Gritti P, Previdi F, Senni M, Ranieri M, and Lorini L

Subjects
Humans, Lung Compliance physiology, Phenotype, Positive-Pressure Respiration, Respiration, Artificial, COVID-19, Respiratory Distress Syndrome therapy
Abstract

Background: Coronavirus disease 2019-associated acute respiratory distress syndrome (COVID-19 ARDS) seems to differ from the "classic ARDS", showing initial significant hypoxemia in the face of relatively preserved compliance and evolving later in a scenario of poorly compliant lungs. We tested the hypothesis that in patients with COVID-19 ARDS, the initial value of static compliance of respiratory system (Crs) (1) depends on the previous duration of the disease (i.e., the fewer days of illness, the higher the Crs and vice versa) and (2) identifies different lung patterns of time evolution and response to prone positioning., Methods: This was a single-center prospective observational study. We enrolled consecutive mechanically ventilated patients with a diagnosis of COVID-19 who met ARDS criteria, admitted to intensive care unit (ICU). Patients were divided in four groups based on quartiles of initial Crs. Relationship between Crs and the previous duration of the disease was evaluated. Respiratory parameters collected once a day and during prone positioning were compared between groups., Results: We evaluated 110 mechanically ventilated patients with a diagnosis of COVID-19 who met ARDS criteria admitted to our ICUs. Patients were divided in groups based on quartiles of initial Crs. The median initial Crs was 41 (32-47) ml/cmH 2 O. No association was found between the previous duration of the disease and the initial Crs. The Crs did not change significantly over time within each quartile. Positive end-expiratory pressure (PEEP) and driving pressure were respectively lower and greater in patients with lower Crs. Prone positioning significantly improved PaO 2 /FiO 2 in the 4 groups, however it increased the Crs significantly only in patients in lower quartile of Crs., Conclusions: In our cohort, the initial Crs is not dependent on the previous duration of COVID-19 disease. Prone positioning improves oxygenation irrespective to initial Crs, but it ameliorates respiratory mechanics only in patients with lower Crs., (© 2022. The Author(s).)

Published
2022
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50. A late Middle Pleistocene Middle Stone Age sequence identified at Wadi Lazalim in southern Tunisia.

Author

Cancellieri E, Bel Hadj Brahim H, Ben Nasr J, Ben Fraj T, Boussoffara R, Di Matteo M, Mercier N, Marnaoui M, Monaco A, Richard M, Mariani GS, Scancarello O, Zerboni A, and di Lernia S

Subjects
Animals, Archaeology, Biological Evolution, Humans, Tunisia, Fossils, Hominidae
Abstract

The late Middle Pleistocene, starting at around 300 ka, witnessed large-scale biological and cultural dynamics in hominin evolution across Africa including the onset of the Middle Stone Age that is closely associated with the evolution of our species-Homo sapiens. However, archaeological and geochronological data of its earliest appearance are scarce. Here we report on the late Middle Pleistocene sequence of Wadi Lazalim, in the Sahara of Southern Tunisia, which has yielded evidence for human occupations bracketed between ca. 300-130 ka. Wadi Lazalim contributes valuable information on the spread of early MSA technocomplexes across North Africa, that likely were an expression of large-scale diffusion processes., (© 2022. The Author(s).)

Published
2022
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