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3. Mendelian randomization prioritizes abdominal adiposity as an independent causal factor for liver fat accumulation and cardiometabolic diseases

Author

Gagnon, Eloi, Pelletier, William, Gobeil, Émilie, Bourgault, Jérôme, Manikpurage, Hasanga D., Maltais-Payette, Ina, Abner, Erik, Taba, Nele, Esko, Tõnu, Mitchell, Patricia L., Ghodsian, Nooshin, Després, Jean-Pierre, Vohl, Marie-Claude, Tchernof, André, Thériault, Sébastien, and Arsenault, Benoit J.

Published
2022
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4. Collaboration between biomedical research and community-based primary health care actors in chronic disease management: a scoping review

Author

Paquette, Jean-Sébastien, Zomahoun, Hervé Tchala Vignon, Diendere, Ella, Lavertu, Gardy, Rheault, Nathalie, Toi, Alfred Kodjo, Leblond, Mathilde, Audet-Walsh, Étienne, Beaulieu, Marie-Claude, Charif, Ali Ben, Blanchette, Virginie, Després, Jean-Pierre, Gaudreau, André, Rhéaume, Caroline, Tremblay, Marie-Claude, and Légaré, France

Published
2022
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7. Long-Term Improvement in Cardiorespiratory Fitness Ameliorates Insulin Sensitivity beyond Changes in Visceral/Ectopic Fat among Men with Visceral Obesity.

Author

Murphy-Després, Adrien, Chartrand, Dominic J., Lemieux, Isabelle, Tremblay, Angelo, Bergeron, Jean, Poirier, Paul, Alméras, Natalie, and Després, Jean-Pierre

Abstract

The SYNERGIE study documented the effects on cardiometabolic risk (CMR) indices of a 1-year lifestyle intervention targeting physical activity (PA) and diet followed by a 2-year maintenance period in men with visceral obesity. Improvements in CMR markers and a decrease in low-attenuation muscle (LAM) area were observed after 1 year. Despite a rebound in visceral adipose tissue (VAT) during the maintenance period, insulin resistance (IR) improved. We tested the hypothesis that variations in cardiorespiratory fitness (CRF) and LAM could explain the long-term improvement in IR. A health (n = 88; mean age 49.0 ± 8.2 years) and fitness (n = 72) evaluation was performed at 0, 1, and 3 years. Participants were classified into two groups based on their CRF response over the maintenance period (worsening: CRF− vs. maintenance/improvement: CRF+). During the maintenance period, changes in the psoas and core LAM areas correlated with changes in IR (r = 0.27; p < 0.05 and r = 0.34; p < 0.005) and changes in CRF (r = −0.31; p < 0.01 and r = −0.30; p < 0.05). IR improved in the CRF+ group (p < 0.05) but remained stable in the CRF− group. Men in the CRF+ group regained half of the changes in VAT volume and LAM at the psoas and mid-thigh compared to the CRF− group (p < 0.05). These results support the importance of targeting VAT and CRF/PA for the long-term management of CMR in men with visceral obesity. [ABSTRACT FROM AUTHOR]

Published
2024
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8. The HERITAGE Family Study: A Review of the Effects of Exercise Training on Cardiometabolic Health, with Insights into Molecular Transducers

Author

SARZYNSKI, MARK A., RICE, TREVA K., DESPRÉS, JEAN-PIERRE, PÉRUSSE, LOUIS, TREMBLAY, ANGELO, STANFORTH, PHILIP R., TCHERNOF, ANDRÉ, BARBER, JACOB L., FALCIANI, FRANCESCO, CLISH, CLARY, ROBBINS, JEREMY M., GHOSH, SUJOY, GERSZTEN, ROBERT E., LEON, ARTHUR S., SKINNER, JAMES S., RAO, D. C., and BOUCHARD, CLAUDE

Published
2022
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9. Heart Disease and Stroke Statistics—2016 Update

Author

Mozaffarian, Dariush, Benjamin, Emelia J, Go, Alan S, Arnett, Donna K, Blaha, Michael J, Cushman, Mary, Das, Sandeep R, de Ferranti, Sarah, Després, Jean-Pierre, Fullerton, Heather J, Howard, Virginia J, Huffman, Mark D, Isasi, Carmen R, Jiménez, Monik C, Judd, Suzanne E, Kissela, Brett M, Lichtman, Judith H, Lisabeth, Lynda D, Liu, Simin, Mackey, Rachel H, Magid, David J, McGuire, Darren K, Mohler, Emile R, Moy, Claudia S, Muntner, Paul, Mussolino, Michael E, Nasir, Khurram, Neumar, Robert W, Nichol, Graham, Palaniappan, Latha, Pandey, Dilip K, Reeves, Mathew J, Rodriguez, Carlos J, Rosamond, Wayne, Sorlie, Paul D, Stein, Joel, Towfighi, Amytis, Turan, Tanya N, Virani, Salim S, Woo, Daniel, Yeh, Robert W, and Turner, Melanie B

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Health Sciences, Clinical Sciences, Sports Science and Exercise, American Heart Association, Data Interpretation, Statistical, Heart Diseases, Humans, Life Style, Research Report, Stroke, United States, AHA Scientific Statements, cardiovascular diseases, epidemiology, risk factors, statistics, stroke, Writing Group Members, American Heart Association Statistics Committee, Stroke Statistics Subcommittee, Cardiorespiratory Medicine and Haematology, Public Health and Health Services, Cardiovascular System & Hematology, Cardiovascular medicine and haematology, Clinical sciences, Sports science and exercise
Published
2016

10. Executive Summary

Author

Mozaffarian, Dariush, Benjamin, Emelia J, Go, Alan S, Arnett, Donna K, Blaha, Michael J, Cushman, Mary, Das, Sandeep R, de Ferranti, Sarah, Després, Jean-Pierre, Fullerton, Heather J, Howard, Virginia J, Huffman, Mark D, Isasi, Carmen R, Jiménez, Monik C, Judd, Suzanne E, Kissela, Brett M, Lichtman, Judith H, Lisabeth, Lynda D, Liu, Simin, Mackey, Rachel H, Magid, David J, McGuire, Darren K, Mohler, Emile R, Moy, Claudia S, Muntner, Paul, Mussolino, Michael E, Nasir, Khurram, Neumar, Robert W, Nichol, Graham, Palaniappan, Latha, Pandey, Dilip K, Reeves, Mathew J, Rodriguez, Carlos J, Rosamond, Wayne, Sorlie, Paul D, Stein, Joel, Towfighi, Amytis, Turan, Tanya N, Virani, Salim S, Woo, Daniel, Yeh, Robert W, and Turner, Melanie B

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Health Sciences, Clinical Sciences, Sports Science and Exercise, American Heart Association, Data Interpretation, Statistical, Health Behavior, Heart Diseases, Humans, Research Report, Stroke, United States, AHA Scientific Statements, cardiovascular diseases, epidemiology, risk factors, statistics, stroke, Writing Group Members, American Heart Association Statistics Committee, Stroke Statistics Subcommittee, Cardiorespiratory Medicine and Haematology, Public Health and Health Services, Cardiovascular System & Hematology, Cardiovascular medicine and haematology, Clinical sciences, Sports science and exercise
Published
2016

11. Executive Summary: Heart Disease and Stroke Statistics--2016 Update: A Report From the American Heart Association.

Author

Writing Group Members, Mozaffarian, Dariush, Benjamin, Emelia J, Go, Alan S, Arnett, Donna K, Blaha, Michael J, Cushman, Mary, Das, Sandeep R, de Ferranti, Sarah, Després, Jean-Pierre, Fullerton, Heather J, Howard, Virginia J, Huffman, Mark D, Isasi, Carmen R, Jiménez, Monik C, Judd, Suzanne E, Kissela, Brett M, Lichtman, Judith H, Lisabeth, Lynda D, Liu, Simin, Mackey, Rachel H, Magid, David J, McGuire, Darren K, Mohler, Emile R, Moy, Claudia S, Muntner, Paul, Mussolino, Michael E, Nasir, Khurram, Neumar, Robert W, Nichol, Graham, Palaniappan, Latha, Pandey, Dilip K, Reeves, Mathew J, Rodriguez, Carlos J, Rosamond, Wayne, Sorlie, Paul D, Stein, Joel, Towfighi, Amytis, Turan, Tanya N, Virani, Salim S, Woo, Daniel, Yeh, Robert W, Turner, Melanie B, American Heart Association Statistics Committee, and Stroke Statistics Subcommittee

Subjects
Writing Group Members, American Heart Association Statistics Committee, Stroke Statistics Subcommittee, Humans, Heart Diseases, Data Interpretation, Statistical, Health Behavior, American Heart Association, United States, Stroke, Research Report, AHA Scientific Statements, cardiovascular diseases, epidemiology, risk factors, statistics, stroke, Data Interpretation, Statistical, Clinical Sciences, Cardiorespiratory Medicine and Haematology, Public Health and Health Services, Cardiovascular System & Hematology
Published
2016

12. Heart Disease and Stroke Statistics-2016 Update: A Report From the American Heart Association.

Author

Writing Group Members, Mozaffarian, Dariush, Benjamin, Emelia J, Go, Alan S, Arnett, Donna K, Blaha, Michael J, Cushman, Mary, Das, Sandeep R, de Ferranti, Sarah, Després, Jean-Pierre, Fullerton, Heather J, Howard, Virginia J, Huffman, Mark D, Isasi, Carmen R, Jiménez, Monik C, Judd, Suzanne E, Kissela, Brett M, Lichtman, Judith H, Lisabeth, Lynda D, Liu, Simin, Mackey, Rachel H, Magid, David J, McGuire, Darren K, Mohler, Emile R, Moy, Claudia S, Muntner, Paul, Mussolino, Michael E, Nasir, Khurram, Neumar, Robert W, Nichol, Graham, Palaniappan, Latha, Pandey, Dilip K, Reeves, Mathew J, Rodriguez, Carlos J, Rosamond, Wayne, Sorlie, Paul D, Stein, Joel, Towfighi, Amytis, Turan, Tanya N, Virani, Salim S, Woo, Daniel, Yeh, Robert W, Turner, Melanie B, American Heart Association Statistics Committee, and Stroke Statistics Subcommittee

Subjects
Writing Group Members, American Heart Association Statistics Committee, Stroke Statistics Subcommittee, Humans, Heart Diseases, Data Interpretation, Statistical, Life Style, American Heart Association, United States, Stroke, Research Report, AHA Scientific Statements, cardiovascular diseases, epidemiology, risk factors, statistics, stroke, Data Interpretation, Statistical, Clinical Sciences, Cardiorespiratory Medicine and Haematology, Public Health and Health Services, Cardiovascular System & Hematology
Published
2016

13. Plasma IGFBP-2 levels reveal heterogeneity in hepatic fat content in adults with excess visceral adiposity

Author

Rauzier, Chloé, primary, Chartrand, Dominic J., additional, Alméras, Natalie, additional, Lemieux, Isabelle, additional, Larose, Eric, additional, Mathieu, Patrick, additional, Pibarot, Philippe, additional, Lamarche, Benoît, additional, Rhéaume, Caroline, additional, Poirier, Paul, additional, Després, Jean-Pierre, additional, and Picard, Frédéric, additional

Published
2023
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14. Executive Summary

Author

Mozaffarian, Dariush, Benjamin, Emelia J, Go, Alan S, Arnett, Donna K, Blaha, Michael J, Cushman, Mary, de Ferranti, Sarah, Després, Jean-Pierre, Fullerton, Heather J, Howard, Virginia J, Huffman, Mark D, Judd, Suzanne E, Kissela, Brett M, Lackland, Daniel T, Lichtman, Judith H, Lisabeth, Lynda D, Liu, Simin, Mackey, Rachel H, Matchar, David B, McGuire, Darren K, Mohler, Emile R, Moy, Claudia S, Muntner, Paul, Mussolino, Michael E, Nasir, Khurram, Neumar, Robert W, Nichol, Graham, Palaniappan, Latha, Pandey, Dilip K, Reeves, Mathew J, Rodriguez, Carlos J, Sorlie, Paul D, Stein, Joel, Towfighi, Amytis, Turan, Tanya N, Virani, Salim S, Willey, Joshua Z, Woo, Daniel, Yeh, Robert W, and Turner, Melanie B

Subjects
Cardiorespiratory Medicine and Haematology, Clinical Sciences, Public Health and Health Services, Cardiovascular System & Hematology
Published
2015

15. Heart disease and stroke statistics--2015 update: a report from the American Heart Association.

Author

Mozaffarian, Dariush, Benjamin, Emelia J, Go, Alan S, Arnett, Donna K, Blaha, Michael J, Cushman, Mary, de Ferranti, Sarah, Després, Jean-Pierre, Fullerton, Heather J, Howard, Virginia J, Huffman, Mark D, Judd, Suzanne E, Kissela, Brett M, Lackland, Daniel T, Lichtman, Judith H, Lisabeth, Lynda D, Liu, Simin, Mackey, Rachel H, Matchar, David B, McGuire, Darren K, Mohler, Emile R, Moy, Claudia S, Muntner, Paul, Mussolino, Michael E, Nasir, Khurram, Neumar, Robert W, Nichol, Graham, Palaniappan, Latha, Pandey, Dilip K, Reeves, Mathew J, Rodriguez, Carlos J, Sorlie, Paul D, Stein, Joel, Towfighi, Amytis, Turan, Tanya N, Virani, Salim S, Willey, Joshua Z, Woo, Daniel, Yeh, Robert W, Turner, Melanie B, and American Heart Association Statistics Committee and Stroke Statistics Subcommittee

Subjects
American Heart Association Statistics Committee and Stroke Statistics Subcommittee, Humans, Heart Diseases, Risk Reduction Behavior, American Heart Association, United States, Stroke, Research Report, AHA Scientific Statements, cardiovascular diseases, epidemiology, risk factors, statistics, stroke, Cardiorespiratory Medicine and Haematology, Clinical Sciences, Public Health and Health Services, Cardiovascular System & Hematology
Published
2015

21. The relationship between yogurt consumption, body weight, and metabolic profiles in youth with a familial predisposition to obesity

Author

Panahi, Shirin, Gallant, Annette, Tremblay, Angelo, Pérusse, Louis, Després, Jean-Pierre, and Drapeau, Vicky

Subjects
Body composition -- Research, Physiological research, Adolescent obesity -- Research, Yogurt -- Research, Body weight, Consumer research, Family, Health, Type 2 diabetes, Insulin resistance, Insulin, Obesity, Family relations, Fasting, EDTA, Youth, Child health, Food/cooking/nutrition, Health
Abstract

Background/objectives This study examined the relationship between yogurt consumption, family history of obesity (FHO), and health determinants. Subjects/methods Youth (n = 198; mean age: 20 [plus or minus] 0.5 years) from the Québec Family Study were first classified based on their FHO, defined as the presence or absence of at least one obese (BMI [greater than or equal to]30 kg/m.sup.2) parent [with FHO (FHO+; n = 112) or without FHO (FHO-; n = 86)] and then on their yogurt consumption [yogurt consumers (YC+) n = 61 or non-consumers (YC-) n = 137]. A two-factor mixed ANOVA was performed to evaluate the association between FHO, YC, and their interaction with health determinant such as weight and body composition, metabolic and behavioral profiles. Results There was a main effect of FHO, but not YC, for weight and body composition, but no interaction between YC and FHO for these measures. However, a significant interaction between YC and FHO was observed for fasting insulin (P = 0.02), insulin area under the curve (AUC) (P = 0.02), and homeostatic model assessment of insulin resistance (HOMA-IR; P = 0.03) after adjustment for studied covariates. Specifically, lower fasting plasma insulin, insulin AUC, and HOMA-IR were observed in FHO+ and YC+ youth compared to YC- youth of the same group while no differences were found between the FHO- sub-groups. Conclusions Consuming yogurt may protect against insulin resistance more specifically among youth at risk of obesity, and this relationship appears to be independent of body composition and lifestyle factors measured in this study., Author(s): Shirin Panahi [sup.1] [sup.2] , Annette Gallant [sup.3] , Angelo Tremblay [sup.1] [sup.4] [sup.5] , Louis Pérusse [sup.1] , Jean-Pierre Després [sup.1] [sup.4] , Vicky Drapeau [sup.2] [sup.4] [sup.5] [...]

Published
2019
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27. The selective peroxisome proliferator-activated receptor alpha modulator (SPPARMα) paradigm: conceptual framework and therapeutic potential: A consensus statement from the International Atherosclerosis Society (IAS) and the Residual Risk Reduction Initiative (R3i) Foundation

Author

Fruchart, Jean-Charles, Santos, Raul D., Aguilar-Salinas, Carlos, Aikawa, Masanori, Al Rasadi, Khalid, Amarenco, Pierre, Barter, Philip J., Ceska, Richard, Corsini, Alberto, Després, Jean-Pierre, Duriez, Patrick, Eckel, Robert H., Ezhov, Marat V., Farnier, Michel, Ginsberg, Henry N., Hermans, Michel P., Ishibashi, Shun, Karpe, Fredrik, Kodama, Tatsuhiko, Koenig, Wolfgang, Krempf, Michel, Lim, Soo, Lorenzatti, Alberto J., McPherson, Ruth, Nuñez-Cortes, Jesus Millan, Nordestgaard, Børge G., Ogawa, Hisao, Packard, Chris J., Plutzky, Jorge, Ponte-Negretti, Carlos I., Pradhan, Aruna, Ray, Kausik K., Reiner, Željko, Ridker, Paul M., Ruscica, Massimiliano, Sadikot, Shaukat, Shimano, Hitoshi, Sritara, Piyamitr, Stock, Jane K., Su, Ta-Chen, Susekov, Andrey V., Tartar, André, Taskinen, Marja-Riitta, Tenenbaum, Alexander, Tokgözoğlu, Lale S., Tomlinson, Brian, Tybjærg-Hansen, Anne, Valensi, Paul, Vrablík, Michal, Wahli, Walter, Watts, Gerald F., Yamashita, Shizuya, Yokote, Koutaro, Zambon, Alberto, and Libby, Peter

Published
2019
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33. Additional file 1 of Fostering translational research in chronic disease management: a logic model proposal

Author

Lavertu, Gardy, Diendere, Ella, Légaré, France, Zomahoun, Hervé Tchala Vignon, Toi, Alfred Kodjo, Leblond, Mathilde, Rheault, Nathalie, Audet-Walsh, Étienne, Beaulieu, Marie-Claude, Ben Charif, Ali, Blanchette, Virginie, Després, Jean-Pierre, Gaudreau, André, Rhéaume, Caroline, Tremblay, Marie-Claude, and Paquette, Jean-Sébastien

Abstract

Additional file 1. List of experts participating in the 2-hour workshop.

Published
2022
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34. Additional file 1 of Collaboration between biomedical research and community-based primary health care actors in chronic disease management: a scoping review

Author

Paquette, Jean-Sébastien, Zomahoun, Hervé Tchala Vignon, Diendere, Ella, Lavertu, Gardy, Rheault, Nathalie, Toi, Alfred Kodjo, Leblond, Mathilde, Audet-Walsh, Étienne, Beaulieu, Marie-Claude, Charif, Ali Ben, Blanchette, Virginie, Després, Jean-Pierre, Gaudreau, André, Rhéaume, Caroline, Tremblay, Marie-Claude, and Légaré, France

Abstract

Additional file1: Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR) checklists

Published
2022
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35. Additional file 3 of Collaboration between biomedical research and community-based primary health care actors in chronic disease management: a scoping review

Author

Paquette, Jean-Sébastien, Zomahoun, Hervé Tchala Vignon, Diendere, Ella, Lavertu, Gardy, Rheault, Nathalie, Toi, Alfred Kodjo, Leblond, Mathilde, Audet-Walsh, Étienne, Beaulieu, Marie-Claude, Charif, Ali Ben, Blanchette, Virginie, Després, Jean-Pierre, Gaudreau, André, Rhéaume, Caroline, Tremblay, Marie-Claude, and Légaré, France

Abstract

Additional file3: List of experts participating in the 2-hour workshop

Published
2022
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36. Additional file 2 of Collaboration between biomedical research and community-based primary health care actors in chronic disease management: a scoping review

Author

Paquette, Jean-Sébastien, Zomahoun, Hervé Tchala Vignon, Diendere, Ella, Lavertu, Gardy, Rheault, Nathalie, Toi, Alfred Kodjo, Leblond, Mathilde, Audet-Walsh, Étienne, Beaulieu, Marie-Claude, Charif, Ali Ben, Blanchette, Virginie, Després, Jean-Pierre, Gaudreau, André, Rhéaume, Caroline, Tremblay, Marie-Claude, and Légaré, France

Abstract

Additional file2: Search strategy

Published
2022
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38. Ethnic influences on the relations between abdominal subcutaneous and visceral adiposity, liver fat, and cardiometabolic risk profile: the International Study of Prediction of Intra-Abdominal Adiposity and Its Relationship With Cardiometabolic Risk/Intra-Abdominal Adiposity

Author

Nazare, Julie-Anne, Smith, Jessica D, Borel, Anne-Laure, Haffner, Steven M, Balkau, Beverley, Ross, Robert, Massien, Christine, Alméras, Natalie, and Després, Jean-Pierre

Published
2012
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39. Abstract EP46: Can Middle-Aged Recreational Cyclists Remain In Energy Balance And Weight Stable When Involved In An Extreme Exercise And Energy Expenditure Intervention (4E Study)? Effect On Visceral Adiposity And Features Of Cardiometabolic Risk

Author

Chartrand, Dominic J, primary, Murphy-Després, Adrien, additional, Lemieux, Isabelle, additional, Larose, Eric, additional, Poirier, Paul, additional, Després, Jean-Pierre, additional, and Alméras, Natalie, additional

Published
2022
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40. Cardiometabolic Health Outcomes Associated With Discordant Visceral and Liver Fat Phenotypes: Insights From the Dallas Heart Study and UK Biobank

Author

Tejani, Sanaa, primary, McCoy, Cody, additional, Ayers, Colby R., additional, Powell-Wiley, Tiffany M., additional, Després, Jean-Pierre, additional, Linge, Jennifer, additional, Leinhard, Olof Dahlqvist, additional, Petersson, Mikael, additional, Borga, Magnus, additional, and Neeland, Ian J., additional

Published
2022
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42. Incorporating fatty liver disease in multidisciplinary care and novel clinical trial designs for patients with metabolic diseases

Author

Eslam, Mohammed, Ahmed, Aijaz, Després, Jean-Pierre, Jha, Vivekanand, Halford, Jason CG, Chieh, Jack Tan Wei, Harris, David C H, Nangaku, Masaomi, Colagiuri, Stephen, Targher, Giovanni, Joshi, Shashank, Byrne, Christopher, Khunti, Kamlesh, Nguyen, Mindie H., Gish, Robert G, and George, Jacob

Abstract

With the global epidemics of obesity and associated conditions, including type 2 diabetes, metabolic dysfunction-associated fatty liver disease, chronic kidney disease, hypertension, stroke, cardiovascular disease, osteoporosis, cancer, and cognitive changes, the prevalence of multimorbidity is rapidly increasing worldwide. In this Review, a panel of international experts from across the spectrum of metabolic diseases come together to identify the challenges and provide perspectives on building a framework for a virtual primary care-driven, patient-centred, multidisciplinary model to deliver holistic care for patients with metabolic dysfunction-associated fatty liver disease and associated metabolic diseases. We focus on clinical care and innovative trial design for metabolic dysfunction-associated fatty liver disease and associated metabolic diseases. This work represents a call to action to promote collaboration and partnerships between stakeholders for improving the lives of people with, or at risk of, metabolic dysfunction-associated fatty liver disease and associated metabolic diseases.

Published
2021

48. Collateral Damage of the COVID‐19 Pandemic on Nutritional Quality and Physical Activity: Perspective from South Korea

Author

Lim, Soo, Lim, Hyunjung, and Després, Jean‐Pierre

Subjects
Nutrition and Dietetics, Coronavirus disease 2019 (COVID-19), business.industry, Endocrinology, Diabetes and Metabolism, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Perspective (graphical), Physical activity, Medicine (miscellaneous), 030209 endocrinology & metabolism, Nutritional quality, medicine.disease_cause, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Covid‐19 Call for Papers, Covid‐19 Call for Paper, Environmental health, Pandemic, medicine, Collateral damage, 030212 general & internal medicine, business, Coronavirus
Abstract

A novel coronavirus (SARS‐CoV‐2), that emerged in the city of Wuhan, China in December 2019, has now spread worldwide.

Published
2020

49. Tratamiento de la obesidad: necesidad de centrar la atención en los pacientes de alto riesgo caracterizados por la obesidad abdominal

Author

Scarsella Carla and Després Jean-Pierre

Subjects
Diabetes, Cardiopatías, Hipertrigliceridemia, Obesidad, Medicine, Public aspects of medicine, RA1-1270
Abstract

La obesidad visceral se asocia a anormalidades metabólicas aumentando el riesgo de diabetes de tipo 2 y de coronariopatía (CP). El Estudio Cardiovascular de Québec demostró que la tríada metabólica aterogénica (TMA) presente en hombres visceralmente obesos (VO), incrementa 20 veces el riesgo de CP durante un período de 5 años. Fue desarrollado un algoritmo de detección precoz a fin de identificar individuos que podrían ser portadores de estas anormalidades aterogénicas. Fue descubierto que la presencia simultánea de una circunferencia de la cintura elevada y una hipertrigliceridemia moderada ("cintura hipertrigliceridémica" - CH) podrían identificar adecuadamente a una proporción significativa de portadores de la TMA. Es importante dejar claro, que incluso en ausencia de los clásicos factores de riesgo los pacientes VO pueden tener un riesgo elevado de CP si presentan la CH. Finalmente, se ha sugerido que el riesgo de desarrollar un síndrome coronario agudo en pacientes VO no está siempre relacionado al grado de estenosis coronaria y debería considerarse el perfil aterotrombótico/inflamatorio del paciente en la valoración del riesgo. La estabilización de la placa aterosclerótica se convertiría en un objetivo terapéutico legítimo y más factible para la prevención de la CP en los pacientes VO.

Published
2003

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