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1. Correction: Acyl-coenzyme a binding protein (ACBP) - a risk factor for cancer diagnosis and an inhibitor of immunosurveillance

Author

Montégut, Léa, Liu, Peng, Zhao, Liwei, Pérez-Lanzón, María, Chen, Hui, Mao, Misha, Zhang, Shuai, Derosa, Lisa, Naour, Julie Le, Lambertucci, Flavia, Mingoia, Silvia, Nogueira-Recalde, Uxía, Mena-Osuna, Rafael, Herranz-Montoya, Irene, Djouder, Nabil, Baulande, Sylvain, Pan, Hui, Joseph, Adrien, Messaoudene, Meriem, Routy, Bertrand, Fidelle, Marine, Ben Ahmed, Tarek, Caron, Olivier, Busson, Pierre, Boulate, David, Deschasaux-Tanguy, Mélanie, Arnault, Nathalie, Pol, Jonathan G., Piaggio, Eliane, Touvier, Mathilde, Zitvogel, Laurence, Delaloge, Suzette, Martins, Isabelle, and Kroemer, Guido

Published
2024
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2. Acyl-coenzyme a binding protein (ACBP) - a risk factor for cancer diagnosis and an inhibitor of immunosurveillance

Author

Montégut, Léa, Liu, Peng, Zhao, Liwei, Pérez-Lanzón, María, Chen, Hui, Mao, Misha, Zhang, Shuai, Derosa, Lisa, Naour, Julie Le, Lambertucci, Flavia, Mingoia, Silvia, Nogueira-Recalde, Uxía, Mena-Osuna, Rafael, Herranz-Montoya, Irene, Djouder, Nabil, Baulande, Sylvain, Pan, Hui, Joseph, Adrien, Messaoudene, Meriem, Routy, Bertrand, Fidelle, Marine, Ben Ahmed, Tarek, Caron, Olivier, Busson, Pierre, Boulate, David, Deschasaux-Tanguy, Mélanie, Arnault, Nathalie, Pol, Jonathan G., Piaggio, Eliane, Touvier, Mathilde, Zitvogel, Laurence, Delaloge, Suzette, Martins, Isabelle, and Kroemer, Guido

Published
2024
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4. Influence of microbiota-associated metabolic reprogramming on clinical outcome in patients with melanoma from the randomized adjuvant dendritic cell-based MIND-DC trial

Author

Alves Costa Silva, Carolina, Piccinno, Gianmarco, Suissa, Déborah, Bourgin, Mélanie, Schreibelt, Gerty, Durand, Sylvère, Birebent, Roxanne, Fidelle, Marine, Sow, Cissé, Aprahamian, Fanny, Manghi, Paolo, Punčochář, Michal, Asnicar, Francesco, Pinto, Federica, Armanini, Federica, Terrisse, Safae, Routy, Bertrand, Drubay, Damien, Eggermont, Alexander M. M., Kroemer, Guido, Segata, Nicola, Zitvogel, Laurence, Derosa, Lisa, Bol, Kalijn F., and de Vries, I. Jolanda M.

Published
2024
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5. Longitudinal gut microbiome changes in immune checkpoint blockade-treated advanced melanoma

Author

Björk, Johannes R., Bolte, Laura A., Maltez Thomas, Andrew, Lee, Karla A., Rossi, Niccolo, Wind, Thijs T., Smit, Lotte M., Armanini, Federica, Asnicar, Francesco, Blanco-Miguez, Aitor, Board, Ruth, Calbet-Llopart, Neus, Derosa, Lisa, Dhomen, Nathalie, Brooks, Kelly, Harland, Mark, Harries, Mark, Lorigan, Paul, Manghi, Paolo, Marais, Richard, Newton-Bishop, Julia, Nezi, Luigi, Pinto, Federica, Potrony, Miriam, Puig, Susana, Serra-Bellver, Patricio, Shaw, Heather M., Tamburini, Sabrina, Valpione, Sara, Waldron, Levi, Zitvogel, Laurence, Zolfo, Moreno, de Vries, Elisabeth G. E., Nathan, Paul, Fehrmann, Rudolf S. N., Spector, Tim D., Bataille, Véronique, Segata, Nicola, Hospers, Geke A. P., and Weersma, Rinse K.

Published
2024
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6. Correction: Metabolomic analyses of COVID-19 patients unravel stage-dependent and prognostic biomarkers

Author

Danlos, François-Xavier, Grajeda-Iglesias, Claudia, Durand, Sylvère, Sauvat, Allan, Roumier, Mathilde, Cantin, Delphine, Colomba, Emeline, Rohmer, Julien, Pommeret, Fanny, Baciarello, Giulia, Willekens, Christophe, Vasse, Marc, Griscelli, Frank, Fahrner, Jean-Eudes, Goubet, Anne-Gaëlle, Dubuisson, Agathe, Derosa, Lisa, Nirmalathasan, Nitharsshini, Bredel, Delphine, Mouraud, Séverine, Pradon, Caroline, Stoclin, Annabelle, Rozenberg, Flore, Duchemin, Jérôme, Jourdi, Georges, Ellouze, Syrine, Levavasseur, Françoise, Albigès, Laurence, Soria, Jean-Charles, Barlesi, Fabrice, Solary, Eric, André, Fabrice, Pène, Frédéric, Ackerman, Félix, Mouthon, Luc, Zitvogel, Laurence, Marabelle, Aurélien, Michot, Jean-Marie, Fontenay, Michaela, and Kroemer, Guido

Published
2024
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7. Fecal microbiota transplantation plus anti-PD-1 immunotherapy in advanced melanoma: a phase I trial

Author

Routy, Bertrand, Lenehan, John G., Miller, Jr, Wilson H., Jamal, Rahima, Messaoudene, Meriem, Daisley, Brendan A., Hes, Cecilia, Al, Kait F., Martinez-Gili, Laura, Punčochář, Michal, Ernst, Scott, Logan, Diane, Belanger, Karl, Esfahani, Khashayar, Richard, Corentin, Ninkov, Marina, Piccinno, Gianmarco, Armanini, Federica, Pinto, Federica, Krishnamoorthy, Mithunah, Figueredo, Rene, Thebault, Pamela, Takis, Panteleimon, Magrill, Jamie, Ramsay, LeeAnn, Derosa, Lisa, Marchesi, Julian R., Parvathy, Seema Nair, Elkrief, Arielle, Watson, Ian R., Lapointe, Rejean, Segata, Nicola, Haeryfar, S.M. Mansour, Mullish, Benjamin H., Silverman, Michael S., Burton, Jeremy P., and Maleki Vareki, Saman

Published
2023
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8. Melanoma and microbiota: Current understanding and future directions

Author

Routy, Bertrand, Jackson, Tanisha, Mählmann, Laura, Baumgartner, Christina K., Blaser, Martin, Byrd, Allyson, Corvaia, Nathalie, Couts, Kasey, Davar, Diwakar, Derosa, Lisa, Hang, Howard C., Hospers, Geke, Isaksen, Morten, Kroemer, Guido, Malard, Florent, McCoy, Kathy D., Meisel, Marlies, Pal, Sumanta, Ronai, Ze’ev, Segal, Eran, Sepich-Poore, Gregory D., Shaikh, Fyza, Sweis, Randy F., Trinchieri, Giorgio, van den Brink, Marcel, Weersma, Rinse K., Whiteson, Katrine, Zhao, Liping, McQuade, Jennifer, Zarour, Hassane, and Zitvogel, Laurence

Published
2024
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9. Author Correction: Fecal microbiota transplantation plus anti-PD-1 immunotherapy in advanced melanoma: a phase I trial

Author

Routy, Bertrand, Lenehan, John G., Miller, Jr, Wilson H., Jamal, Rahima, Messaoudene, Meriem, Daisley, Brendan A., Hes, Cecilia, Al, Kait F., Martinez-Gili, Laura, Punčochář, Michal, Ernst, Scott, Logan, Diane, Belanger, Karl, Esfahani, Khashayar, Richard, Corentin, Ninkov, Marina, Piccinno, Gianmarco, Armanini, Federica, Pinto, Federica, Krishnamoorthy, Mithunah, Figueredo, Rene, Thebault, Pamela, Takis, Panteleimon, Magrill, Jamie, Ramsay, LeeAnn, Derosa, Lisa, Marchesi, Julian R., Parvathy, Seema Nair, Elkrief, Arielle, Watson, Ian R., Lapointe, Rejean, Segata, Nicola, Haeryfar, S.M. Mansour, Mullish, Benjamin H., Silverman, Michael S., Burton, Jeremy P., and Maleki Vareki, Saman

Published
2024
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10. Benzodiazepines compromise the outcome of cancer immunotherapy.

Author

Montégut, Léa, Derosa, Lisa, Messaoudene, Meriem, Chen, Hui, Lambertucci, Flavia, Routy, Bertrand, Zitvogel, Laurence, Martins, Isabelle, and Kroemer, Guido

Abstract

Acyl CoA binding protein (ACBP, which is encoded by diazepam binding inhibitor, DBI) acts on the gamma-amino butyric acid (GABA) receptor type A via a specific binding site that is shared by diazepam and other benzodiazepines. Both ACBP/DBI and benzodiazepines act as positive allosteric modulators, hence increasing GABA effects on this receptor. Recently, we found that ACBP/DBI acts as an endogenous immunosuppressor, meaning that its antibody-mediated neutralization has immunostimulatory effects and enhances the efficacy of immunotherapy and chemoimmunotherapy in mouse models. Driven by these considerations, we investigated whether diazepam administration in mice would reverse the beneficial effects of ACBP/DBI neutralization on cancer chemoimmunotherapy. Indeed, diazepam abolished the therapeutic of anti-ACBP/DBI antibodies, supporting the idea that diazepam exerts immunosuppressive properties. Of note, treatment with benzodiazepines was associated with poor clinical responses to chemoimmunotherapy in patients with non-small cell lung cancer (NSCLC) as compared to individuals not receiving any psychotropic drugs. Medication with other psychotropic drugs than benzodiazepines did not compromise the outcome of chemoimmunotherapy, indicating that this immunosuppressive effect was benzodiazepine specific. We conclude that benzodiazepines may confer systemic immunosuppression. This hypothesis requires further epidemiological and clinical confirmation. [ABSTRACT FROM AUTHOR]

Published
2024
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11. Faecalibacterium prausnitzii strain EXL01 boosts efficacy of immune checkpoint inhibitors.

Author

Bredon, Marius, Danne, Camille, Pham, Hang Phuong, Ruffié, Pauline, Bessede, Alban, Rolhion, Nathalie, Creusot, Laura, Brot, Loic, Alonso, Iria, Langella, Philippe, Derosa, Lisa, Cortot, Alexis B., Routy, Bertrand, Zitvogel, Laurence, Segata, Nicola, and Sokol, Harry

Abstract

Gut microbiota impacts responses to immune checkpoint inhibitors (ICI). A high level of Faecalibacterium prausnitzii have been associated with a positive response to ICI in multiple cancer types. Here, based on fecal shotgun metagenomics data, we show in two independent cohorts of patients with non-small cell lung cancer and advanced melanoma that a high level of F. prausnitzii at baseline is positively associated with a better clinical response to ICI. In MCA205 tumor-bearing mice, administration of F.prausnitzii strain EXL01, already in clinical development for Inflammatory Bowel Disease, restores the anti-tumor response to ICI in the context of antibiotic-induced microbiota perturbation at clinical and tumor transcriptomics level. In vitro, EXL01 strain enhances T cell activation in the presence of ICI. Interestingly, oral administration of EXL01 strain did not induce any change in fecal microbiota diversity or composition, suggesting a direct effect on immune cells in the small intestine. F. prausnitzii strain EXL01 will be evaluated as an adjuvant to ICI in multiple cancers in the near future. [ABSTRACT FROM AUTHOR]

Published
2024
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12. Cross-cohort gut microbiome associations with immune checkpoint inhibitor response in advanced melanoma

Author

Lee, Karla A., Thomas, Andrew Maltez, Bolte, Laura A., Björk, Johannes R., de Ruijter, Laura Kist, Armanini, Federica, Asnicar, Francesco, Blanco-Miguez, Aitor, Board, Ruth, Calbet-Llopart, Neus, Derosa, Lisa, Dhomen, Nathalie, Brooks, Kelly, Harland, Mark, Harries, Mark, Leeming, Emily R., Lorigan, Paul, Manghi, Paolo, Marais, Richard, Newton-Bishop, Julia, Nezi, Luigi, Pinto, Federica, Potrony, Miriam, Puig, Susana, Serra-Bellver, Patricio, Shaw, Heather M., Tamburini, Sabrina, Valpione, Sara, Vijay, Amrita, Waldron, Levi, Zitvogel, Laurence, Zolfo, Moreno, de Vries, Elisabeth G. E., Nathan, Paul, Fehrmann, Rudolf S. N., Bataille, Véronique, Hospers, Geke A. P., Spector, Tim D., Weersma, Rinse K., and Segata, Nicola

Published
2022
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13. Intestinal Akkermansia muciniphila predicts clinical response to PD-1 blockade in patients with advanced non-small-cell lung cancer

Author

Derosa, Lisa, Routy, Bertrand, Thomas, Andrew Maltez, Iebba, Valerio, Zalcman, Gerard, Friard, Sylvie, Mazieres, Julien, Audigier-Valette, Clarisse, Moro-Sibilot, Denis, Goldwasser, François, Silva, Carolina Alves Costa, Terrisse, Safae, Bonvalet, Melodie, Scherpereel, Arnaud, Pegliasco, Hervé, Richard, Corentin, Ghiringhelli, François, Elkrief, Arielle, Desilets, Antoine, Blanc-Durand, Felix, Cumbo, Fabio, Blanco, Aitor, Boidot, Romain, Chevrier, Sandy, Daillère, Romain, Kroemer, Guido, Alla, Laurie, Pons, Nicolas, Le Chatelier, Emmanuelle, Galleron, Nathalie, Roume, Hugo, Dubuisson, Agathe, Bouchard, Nicole, Messaoudene, Meriem, Drubay, Damien, Deutsch, Eric, Barlesi, Fabrice, Planchard, David, Segata, Nicola, Martinez, Stéphanie, Zitvogel, Laurence, Soria, Jean-Charles, and Besse, Benjamin

Published
2022
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14. Prolonged SARS-CoV-2 RNA virus shedding and lymphopenia are hallmarks of COVID-19 in cancer patients with poor prognosis

Author

Goubet, Anne-Gaëlle, Dubuisson, Agathe, Geraud, Arthur, Danlos, François-Xavier, Terrisse, Safae, Silva, Carolina Alves Costa, Drubay, Damien, Touri, Lea, Picard, Marion, Mazzenga, Marine, Silvin, Aymeric, Dunsmore, Garett, Haddad, Yacine, Pizzato, Eugenie, Ly, Pierre, Flament, Caroline, Melenotte, Cléa, Solary, Eric, Fontenay, Michaela, Garcia, Gabriel, Balleyguier, Corinne, Lassau, Nathalie, Maeurer, Markus, Grajeda-Iglesias, Claudia, Nirmalathasan, Nitharsshini, Aprahamian, Fanny, Durand, Sylvère, Kepp, Oliver, Ferrere, Gladys, Thelemaque, Cassandra, Lahmar, Imran, Fahrner, Jean-Eudes, Meziani, Lydia, Ahmed-Belkacem, Abdelhakim, Saïdani, Nadia, La Scola, Bernard, Raoult, Didier, Gentile, Stéphanie, Cortaredona, Sébastien, Ippolito, Giuseppe, Lelouvier, Benjamin, Roulet, Alain, Andre, Fabrice, Barlesi, Fabrice, Soria, Jean-Charles, Pradon, Caroline, Gallois, Emmanuelle, Pommeret, Fanny, Colomba, Emeline, Ginhoux, Florent, Kazandjian, Suzanne, Elkrief, Arielle, Routy, Bertrand, Miyara, Makoto, Gorochov, Guy, Deutsch, Eric, Albiges, Laurence, Stoclin, Annabelle, Gachot, Bertrand, Florin, Anne, Merad, Mansouria, Scotte, Florian, Assaad, Souad, Kroemer, Guido, Blay, Jean-Yves, Marabelle, Aurélien, Griscelli, Frank, Zitvogel, Laurence, and Derosa, Lisa

Published
2021
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15. Cross-tissue single-cell landscape of human monocytes and macrophages in health and disease

Author

Mulder, Kevin, Patel, Amit Ashok, Kong, Wan Ting, Piot, Cécile, Halitzki, Evelyn, Dunsmore, Garett, Khalilnezhad, Shabnam, Irac, Sergio Erdal, Dubuisson, Agathe, Chevrier, Marion, Zhang, Xiao Meng, Tam, John Kit Chung, Lim, Tony Kiat Hon, Wong, Regina Men Men, Pai, Rhea, Khalil, Ahmed Ibrahim Samir, Chow, Pierce Kah Hoe, Wu, Suny Z., Al-Eryani, Ghamdan, Roden, Daniel, Swarbrick, Alexander, Chan, Jerry Kok Yen, Albani, Salvatore, Derosa, Lisa, Zitvogel, Laurence, Sharma, Ankur, Chen, Jinmiao, Silvin, Aymeric, Bertoletti, Antonio, Blériot, Camille, Dutertre, Charles-Antoine, and Ginhoux, Florent

Published
2021
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16. Gut microbiota signatures are associated with toxicity to combined CTLA-4 and PD-1 blockade

Author

Andrews, Miles C., Duong, Connie P. M., Gopalakrishnan, Vancheswaran, Iebba, Valerio, Chen, Wei-Shen, Derosa, Lisa, and Khan, Md Abdul Wadud

Subjects
Microbiota (Symbiotic organisms) -- Health aspects, Immunotherapy -- Complications and side effects, Melanoma -- Development and progression -- Care and treatment, Biological sciences, Health
Abstract

Treatment with combined immune checkpoint blockade (CICB) targeting CTLA-4 and PD-1 is associated with clinical benefit across tumor types, but also a high rate of immune-related adverse events. Insights into biomarkers and mechanisms of response and toxicity to CICB are needed. To address this, we profiled the blood, tumor and gut microbiome of 77 patients with advanced melanoma treated with CICB, with a high rate of any [greater than or equal to]grade 3 immune-related adverse events (49%) with parallel studies in pre-clinical models. Tumor-associated immune and genomic biomarkers of response to CICB were similar to those identified for ICB monotherapy, and toxicity from CICB was associated with a more diverse peripheral T-cell repertoire. Profiling of gut microbiota demonstrated a significantly higher abundance of Bacteroides intestinalis in patients with toxicity, with upregulation of mucosal IL-1[beta] in patient samples of colitis and in pre-clinical models. Together, these data offer potential new therapeutic angles for targeting toxicity to CICB. Clinical benefit or intestinal toxicity resulting from combined immune checkpoint blockade in patients with melanoma associates with prevalent commensal bacteria and can be decoupled by IL-1R inhibition., Author(s): Miles C. Andrews [sup.1] [sup.2] [sup.3] , Connie P. M. Duong [sup.4] [sup.5] [sup.6] , Vancheswaran Gopalakrishnan [sup.1] , Valerio Iebba [sup.4] [sup.5] , Wei-Shen Chen [sup.7] [sup.8] , [...]

Published
2021
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17. Intestinal microbiota influences clinical outcome and side effects of early breast cancer treatment

Author

Terrisse, Safae, Derosa, Lisa, Iebba, Valerio, Ghiringhelli, François, Vaz-Luis, Ines, Kroemer, Guido, Fidelle, Marine, Christodoulidis, Stergios, Segata, Nicola, Thomas, Andrew Maltez, Martin, Anne-Laure, Sirven, Aude, Everhard, Sibille, Aprahamian, Fanny, Nirmalathasan, Nitharsshini, Aarnoutse, Romy, Smidt, Marjolein, Ziemons, Janine, Caldas, Carlos, Loibl, Sibylle, Denkert, Carsten, Durand, Sylvere, Iglesias, Claudia, Pietrantonio, Filippo, Routy, Bertrand, André, Fabrice, Pasolli, Edoardo, Delaloge, Suzette, and Zitvogel, Laurence

Published
2021
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18. Multifaceted modes of action of the anticancer probiotic Enterococcus hirae

Author

Goubet, Anne-Gaëlle, Wheeler, Richard, Fluckiger, Aurélie, Qu, Bo, Lemaître, Fabien, Iribarren, Kristina, Mondragón, Laura, Tidjani Alou, Maryam, Pizzato, Eugénie, Durand, Sylvère, Derosa, Lisa, Aprahamian, Fanny, Bossut, Noélie, Moya-Nilges, Maryse, Derrien, Diane, Chen, Guo, Leduc, Marion, Joseph, Adrien, Pons, Nicolas, Le Chatelier, Emmanuelle, Segata, Nicola, Yonekura, Satoru, Iebba, Valerio, Kepp, Oliver, Raoult, Didier, André, Fabrice, Kroemer, Guido, Boneca, Ivo Gomperts, Zitvogel, Laurence, and Daillère, Romain

Published
2021
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19. Influence of microbiota-associated metabolic reprogramming on clinical outcome in patients with melanoma from the randomized adjuvant dendritic cell-based MIND-DC trial

Author

MS Hematologie, Alves Costa Silva, Carolina, Piccinno, Gianmarco, Suissa, Déborah, Bourgin, Mélanie, Schreibelt, Gerty, Durand, Sylvère, Birebent, Roxanne, Fidelle, Marine, Sow, Cissé, Aprahamian, Fanny, Manghi, Paolo, Punčochář, Michal, Asnicar, Francesco, Pinto, Federica, Armanini, Federica, Terrisse, Safae, Routy, Bertrand, Drubay, Damien, Eggermont, Alexander M.M., Kroemer, Guido, Segata, Nicola, Zitvogel, Laurence, Derosa, Lisa, Bol, Kalijn F., de Vries, I. Jolanda M., MS Hematologie, Alves Costa Silva, Carolina, Piccinno, Gianmarco, Suissa, Déborah, Bourgin, Mélanie, Schreibelt, Gerty, Durand, Sylvère, Birebent, Roxanne, Fidelle, Marine, Sow, Cissé, Aprahamian, Fanny, Manghi, Paolo, Punčochář, Michal, Asnicar, Francesco, Pinto, Federica, Armanini, Federica, Terrisse, Safae, Routy, Bertrand, Drubay, Damien, Eggermont, Alexander M.M., Kroemer, Guido, Segata, Nicola, Zitvogel, Laurence, Derosa, Lisa, Bol, Kalijn F., and de Vries, I. Jolanda M.

Published
2024

20. State of the art and the future of microbiome-based biomarkers:a multidisciplinary Delphi consensus

Author

Rodriguez, Julie, Hassani, Zahra, Alves Costa Silva, Carolina, Betsou, Fay, Carraturo, Federica, Fasano, Alessio, Israelsen, Mads, Iyappan, Anandhi, Krag, Aleksander, Metwaly, Amira, Schierwagen, Robert, Trebicka, Jonel, Zwart, Hub, Doré, Joel, Cordaillat-Simmons, Magali, Druart, Celine, Godoy, Yolanda, Bork, Peer, Typas, Nassos, Hazenbrink, Dienty Hendrina Maria Johanna, Zitvogel, Laurence, Derosa, Lisa, Blottière, Hervé, Kriaa, Aicha, Maguin, Emmanuelle, Rhimi, Moez, Veiga, Patrick, Pons, Nicolas, Prost, Pierre Louis, Jarde, Alexander, Boutron, Isabelle, Ravaud, Philippe, Falk Villesen, Ida, Haller, Dirk, Ross, Paul, O'Toole, Paul, Lavelle, Aonghus, Claesson, Marcus, Joos, Raphaela, Hill, Colin, Shkoporov, Andrey, Loftus, Saba, Boucher, Katy, Arumugam, Manimozhayan, Sarathi, Arjun, Morozova, Vitalina, Segata, Nicola, Asnicar, Francesco, Pinto, Federica, Rodriguez, Julie, Hassani, Zahra, Alves Costa Silva, Carolina, Betsou, Fay, Carraturo, Federica, Fasano, Alessio, Israelsen, Mads, Iyappan, Anandhi, Krag, Aleksander, Metwaly, Amira, Schierwagen, Robert, Trebicka, Jonel, Zwart, Hub, Doré, Joel, Cordaillat-Simmons, Magali, Druart, Celine, Godoy, Yolanda, Bork, Peer, Typas, Nassos, Hazenbrink, Dienty Hendrina Maria Johanna, Zitvogel, Laurence, Derosa, Lisa, Blottière, Hervé, Kriaa, Aicha, Maguin, Emmanuelle, Rhimi, Moez, Veiga, Patrick, Pons, Nicolas, Prost, Pierre Louis, Jarde, Alexander, Boutron, Isabelle, Ravaud, Philippe, Falk Villesen, Ida, Haller, Dirk, Ross, Paul, O'Toole, Paul, Lavelle, Aonghus, Claesson, Marcus, Joos, Raphaela, Hill, Colin, Shkoporov, Andrey, Loftus, Saba, Boucher, Katy, Arumugam, Manimozhayan, Sarathi, Arjun, Morozova, Vitalina, Segata, Nicola, Asnicar, Francesco, and Pinto, Federica

Abstract

Although microbiome signatures have been identified in various contexts (ie, pathogenesis of non-communicable diseases and treatment response), qualified microbiome-based biomarkers are currently not in use in clinical practice. The Human Microbiome Action consortium initiated a Delphi survey to establish a consensus on the needs, challenges, and limitations in developing qualified microbiome-based biomarkers. The questionnaire was developed by a scientific committee via literature review and expert interviews. To ensure broad applicability of the results, 307 experts were invited to participate; 114 of them responded to the first round of the survey, 93 of whom completed the second and final round as well. The survey highlighted the experts’ confidence in the potential of microbiome-based biomarkers for several indications or pathologies. The paucity of validated analytical methods appears to be the principal factor hindering the qualification of these biomarkers. The survey also showed that clinical implementation of these biomarkers would only be possible if kitted and validated molecular assays with simple interpretation are developed. This initiative serves as a foundation for designing and implementing public-private collaborative projects to overcome the challenges and promote clinical application of microbiome-based biomarkers.

Published
2024

21. Elevated Calprotectin and Abnormal Myeloid Cell Subsets Discriminate Severe from Mild COVID-19

Author

Silvin, Aymeric, Chapuis, Nicolas, Dunsmore, Garett, Goubet, Anne-Gaëlle, Dubuisson, Agathe, Derosa, Lisa, Almire, Carole, Hénon, Clémence, Kosmider, Olivier, Droin, Nathalie, Rameau, Philippe, Catelain, Cyril, Alfaro, Alexia, Dussiau, Charles, Friedrich, Chloé, Sourdeau, Elise, Marin, Nathalie, Szwebel, Tali-Anne, Cantin, Delphine, Mouthon, Luc, Borderie, Didier, Deloger, Marc, Bredel, Delphine, Mouraud, Severine, Drubay, Damien, Andrieu, Muriel, Lhonneur, Anne-Sophie, Saada, Véronique, Stoclin, Annabelle, Willekens, Christophe, Pommeret, Fanny, Griscelli, Frank, Ng, Lai Guan, Zhang, Zheng, Bost, Pierre, Amit, Ido, Barlesi, Fabrice, Marabelle, Aurélien, Pène, Frédéric, Gachot, Bertrand, André, Fabrice, Zitvogel, Laurence, Ginhoux, Florent, Fontenay, Michaela, and Solary, Eric

Published
2020
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23. Chemotherapy-induced ileal crypt apoptosis and the ileal microbiome shape immunosurveillance and prognosis of proximal colon cancer

Author

Roberti, Maria Paula, Yonekura, Satoru, Duong, Connie P. M., Picard, Marion, Ferrere, Gladys, Tidjani Alou, Maryam, Rauber, Conrad, Iebba, Valerio, Lehmann, Christian H. K., Amon, Lukas, Dudziak, Diana, Derosa, Lisa, Routy, Bertrand, Flament, Caroline, Richard, Corentin, Daillère, Romain, Fluckiger, Aurélie, Van Seuningen, Isabelle, Chamaillard, Mathias, Vincent, Audrey, Kourula, Stephanie, Opolon, Paule, Ly, Pierre, Pizzato, Eugénie, Becharef, Sonia, Paillet, Juliette, Klein, Christophe, Marliot, Florence, Pietrantonio, Filippo, Benoist, Stéphane, Scoazec, Jean-Yves, Dartigues, Peggy, Hollebecque, Antoine, Malka, David, Pagès, Franck, Galon, Jérôme, Gomperts Boneca, Ivo, Lepage, Patricia, Ryffel, Bernard, Raoult, Didier, Eggermont, Alexander, Vanden Berghe, Tom, Ghiringhelli, François, Vandenabeele, Peter, Kroemer, Guido, and Zitvogel, Laurence

Published
2020
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28. Metabolomic analyses of COVID-19 patients unravel stage-dependent and prognostic biomarkers

Author

Danlos, François-Xavier, Grajeda-Iglesias, Claudia, Durand, Sylvère, Sauvat, Allan, Roumier, Mathilde, Cantin, Delphine, Colomba, Emeline, Rohmer, Julien, Pommeret, Fanny, Baciarello, Giulia, Willekens, Christophe, Vasse, Marc, Griscelli, Frank, Fahrner, Jean-Eudes, Goubet, Anne-Gaëlle, Dubuisson, Agathe, Derosa, Lisa, Nirmalathasan, Nitharsshini, Bredel, Delphine, Mouraud, Séverine, Pradon, Caroline, Stoclin, Annabelle, Rozenberg, Flore, Duchemin, Jérôme, Jourdi, Georges, Ellouze, Syrine, Levavasseur, Françoise, Albigès, Laurence, Soria, Jean-Charles, Barlesi, Fabrice, Solary, Eric, André, Fabrice, Pène, Frédéric, Ackerman, Félix, Mouthon, Luc, Zitvogel, Laurence, Marabelle, Aurélien, Michot, Jean-Marie, Fontenay, Michaela, and Kroemer, Guido

Published
2021
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29. Immunodynamics of explanted human tumors for immuno‐oncology

Author

Dubuisson, Agathe, Fahrner, Jean‐Eudes, Goubet, Anne‐Gaëlle, Terrisse, Safae, Voisin, Nicolas, Bayard, Charles, Lofek, Sebastien, Drubay, Damien, Bredel, Delphine, Mouraud, Séverine, Susini, Sandrine, Cogdill, Alexandria, Rebuffet, Lucas, Ballot, Elise, Jacquelot, Nicolas, Thomas de Montpreville, Vincent, Casiraghi, Odile, Radulescu, Camélia, Ferlicot, Sophie, Figueroa, David J, Yadavilli, Sapna, Waight, Jeremy D, Ballas, Marc, Hoos, Axel, Condamine, Thomas, Parier, Bastien, Gaudillat, Christophe, Routy, Bertrand, Ghiringhelli, François, Derosa, Lisa, Breuskin, Ingrid, Rouanne, Mathieu, André, Fabrice, Lebacle, Cédric, Baumert, Hervé, Wislez, Marie, Fadel, Elie, Cremer, Isabelle, Albiges, Laurence, Geoerger, Birgit, Scoazec, Jean‐Yves, Loriot, Yohann, Kroemer, Guido, Marabelle, Aurélien, Bonvalet, Mélodie, and Zitvogel, Laurence

Published
2021
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31. RBD- specific Th1 responses are associated with vaccine-induced protection against SARS-CoV-2 infection in patients with hematological malignancies

Author

Bigenwald, Camille, primary, Haddad, Yacine, additional, Thelemaque, Cassandra, additional, Carrier, Agathe, additional, Birebent, Roxanne, additional, Ly, Pierre, additional, Flament, Caroline, additional, Lahmar, Imran, additional, de Sousa, Eric, additional, Maeurer, Markus, additional, Miyara, Makoto, additional, Assi, Tarek, additional, Castilla-Llorente, Cristina, additional, Willekens, Christophe, additional, Fayemi, Céline, additional, Lazarovici, Julien, additional, Marabelle, Aurélien, additional, Derosa, Lisa, additional, Ribrag, Vincent, additional, and Zitvogel, Laurence, additional

Published
2023
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33. Weight and skeletal muscle loss with cabozantinib in metastatic renal cell carcinoma

Author

Colomba, Emeline, primary, Alves Costa Silva, Carolina, additional, Le Teuff, Gwénaël, additional, Elmawieh, Jamie, additional, Afonso, Daniel, additional, Benchimol‐Zouari, Axelle, additional, Guida, Annalisa, additional, Derosa, Lisa, additional, Flippot, Ronan, additional, Raynard, Bruno, additional, Escudier, Bernard, additional, Bidault, François, additional, and Albiges, Laurence, additional

Published
2022
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34. Cancer induces a stress ileopathy depending on B-adrenergic receptors and promoting dysbiosis that contribute to carcinogenesis

Author

Yonekura, Satoru, Terrisse, Safae, Alves Costa Silva, Carolina, Lafarge, Antoine, Iebba, Valerio, Ferrere, Gladys, Goubet, Anne-Gaelle, Fahrner, Jean-Eudes, Lahmar, Imran, Ueda, Kosuke, Mansouri, Gibrail, Pizzato, Eugenie, Ly, Pierre, Mazzenga, Marine, Thelemaque, Cassandra, Fidelle, Marine, Jaulin, Fanny, Cartry, Jerome, Deloger, Marc, Aglave, Marine, Droin, Nathalie, Opolon, Paule, Puget, Angelique, Mann, Fanny, Neunlist, Michel, Bessard, Anne, Aymeric, Laetitia, Matysiak-Budnik, Tamara, Bosq, Jacques, Hofman, Paul, Duong, Connie P M, Ugolini, Sophie, Quiniou, Valentin, Berrard, Sylvie, Ryffel, Bernhard, Kepp, Oliver, Kroemer, Guido, Routy, Bertrand, Lordello, Leonardo, Bani, Mohamed-Amine, Segata, Nicola, Yousef Yengej, Fjodor, Clevers, Hans, Scoazec, Jean-Yves, Pasolli, Edoardo, Derosa, Lisa, Zitvogel, Laurence, Yonekura, Satoru, Terrisse, Safae, Alves Costa Silva, Carolina, Lafarge, Antoine, Iebba, Valerio, Ferrere, Gladys, Goubet, Anne-Gaelle, Fahrner, Jean-Eudes, Lahmar, Imran, Ueda, Kosuke, Mansouri, Gibrail, Pizzato, Eugenie, Ly, Pierre, Mazzenga, Marine, Thelemaque, Cassandra, Fidelle, Marine, Jaulin, Fanny, Cartry, Jerome, Deloger, Marc, Aglave, Marine, Droin, Nathalie, Opolon, Paule, Puget, Angelique, Mann, Fanny, Neunlist, Michel, Bessard, Anne, Aymeric, Laetitia, Matysiak-Budnik, Tamara, Bosq, Jacques, Hofman, Paul, Duong, Connie P M, Ugolini, Sophie, Quiniou, Valentin, Berrard, Sylvie, Ryffel, Bernhard, Kepp, Oliver, Kroemer, Guido, Routy, Bertrand, Lordello, Leonardo, Bani, Mohamed-Amine, Segata, Nicola, Yousef Yengej, Fjodor, Clevers, Hans, Scoazec, Jean-Yves, Pasolli, Edoardo, Derosa, Lisa, and Zitvogel, Laurence

Abstract

Gut dysbiosis has been associated with intestinal and extra-intestinal malignancies but whether and how carcinogenesis drives compositional shifts of the microbiome to its own benefit remains an open conundrum. Here we show that malignant processes can cause ileal mucosa atrophy, with villous microvascular constriction associated with dominance of sympathetic over cholinergic signaling. Rapid onset of tumorigenesis induced a burst of Reg3y release by ileal cells, and transient epithelial barrier permeability that culminated in overt and long lasting dysbiosis dominated by Gram positive Clostridium species. Pharmacological blockade of B-adrenergic receptors or genetic deficiency in Adrb2 gene, vancomycin or co-housing of tumor bearers with tumor free littermates prevented cancer-induced ileopathy, eventually slowing tumor growth kinetics. Cancer patients harbor distinct hallmarks of this stress ileopathy dominated by Clostridium species. Hence, stress ileopathy is a corollary disease of extra-intestinal malignancies requiring specific therapies.

Published
2022

35. Cancer Induces a Stress Ileopathy Depending on beta-Adrenergic Receptors and Promoting Dysbiosis that Contributes to Carcinogenesis

Author

Nefro Vasculaire Geneeskunde, CMM, Cancer, Hubrecht Institute with UMC, Yonekura, Satoru, Terrisse, Safae, Silva, Carolina Alves Costa, Lafarge, Antoine, Iebba, Valerio, Ferrere, Gladys, Goubet, Anne Gaëlle, Fahrner, Jean Eudes, Lahmar, Imran, Ueda, Kousuke, Mansouri, Gibrail, Pizzato, Eugénie, Ly, Pierre, Mazzenga, Marine, Thelemaque, Cassandra, Fidelle, Marine, Jaulin, Fanny, Cartry, Jérôme, Deloger, Marc, Aglave, Marine, Droin, Nathalie, Opolon, Paule, Puget, Angélique, Mann, Fanny, Neunlist, Michel, Bessard, Anne, Aymeric, Laetitia, Matysiak-Budnik, Tamara, Bosq, Jacques, Hofman, Paul, Duong, Connie P.M., Ugolini, Sophie, Quiniou, Valentin, Berrard, Sylvie, Ryffel, Bernhard, Kepp, Oliver, Kroemer, Guido, Routy, Bertrand, Lordello, Leonardo, Bani, Mohamed Amine, Segata, Nicola, Yengej, Fjodor Yousef, Clevers, Hans, Scoazec, Jean Yves, Pasolli, Edoardo, Derosa, Lisa, Zitvogel, Laurence, Nefro Vasculaire Geneeskunde, CMM, Cancer, Hubrecht Institute with UMC, Yonekura, Satoru, Terrisse, Safae, Silva, Carolina Alves Costa, Lafarge, Antoine, Iebba, Valerio, Ferrere, Gladys, Goubet, Anne Gaëlle, Fahrner, Jean Eudes, Lahmar, Imran, Ueda, Kousuke, Mansouri, Gibrail, Pizzato, Eugénie, Ly, Pierre, Mazzenga, Marine, Thelemaque, Cassandra, Fidelle, Marine, Jaulin, Fanny, Cartry, Jérôme, Deloger, Marc, Aglave, Marine, Droin, Nathalie, Opolon, Paule, Puget, Angélique, Mann, Fanny, Neunlist, Michel, Bessard, Anne, Aymeric, Laetitia, Matysiak-Budnik, Tamara, Bosq, Jacques, Hofman, Paul, Duong, Connie P.M., Ugolini, Sophie, Quiniou, Valentin, Berrard, Sylvie, Ryffel, Bernhard, Kepp, Oliver, Kroemer, Guido, Routy, Bertrand, Lordello, Leonardo, Bani, Mohamed Amine, Segata, Nicola, Yengej, Fjodor Yousef, Clevers, Hans, Scoazec, Jean Yves, Pasolli, Edoardo, Derosa, Lisa, and Zitvogel, Laurence

Published
2022

37. Intestinal Akkermansia muciniphila predicts clinical response to PD-1 blockade in advanced non-small cell lung cancer patients

Author

Derosa, Lisa, Routy, Bertrand, Thomas, Andrew Maltez, Iebba, Valerio, Zalcman, Gerard, Friard, Sylvie, Mazieres, Julien, Audigier-Valette, Clarisse, Moro-Sibilot, Denis, Goldwasser, François, Silva, Carolina Alves Costa, Terrisse, Safae, Bonvalet, Melodie, Scherpereel, Arnaud, Pegliasco, Hervé, Richard, Corentin, Ghiringhelli, François, Elkrief, Arielle, Desilets, Antoine, Blanc-Durand, Felix, Cumbo, Fabio, Blanco, Aitor, Boidot, Romain, Chevrier, Sandy, Daillère, Romain, Kroemer, Guido, Alla, Laurie, Pons, Nicolas, Chatelier, Emmanuelle Le, Galleron, Nathalie, Roume, Hugo, Dubuisson, Agathe, Bouchard, Nicole, Messaoudene, Meriem, Drubay, Damien, Deutsch, Eric, Barlesi, Fabrice, Planchard, David, Segata, Nicola, Martinez, Stéphanie, Zitvogel, Laurence, Soria, Jean-Charles, and Besse, Benjamin

Subjects
Lung Neoplasms, Carcinoma, Non-Small-Cell Lung, Humans, Immunologic Factors, Akkermansia, Immunotherapy, Article
Abstract

Aside from PD-L1 expression, biomarkers of response to immune checkpoint inhibitors (ICI) in non-small cell lung cancer (NSCLC) are needed. We previously reported in 100 NSCLC and kidney cancer patients that fecal Akkermansia muciniphila (Akk) correlated with ICI clinical success. The endpoint of this study was to prospectively validate the prognostic significance of fecal Akk in advanced NSCLC patients treated with first or second line ICI. We performed shotgun metagenomics-based microbiome profiling using two different pipelines in 338 NSCLC patients. Baseline stool Akk was associated with increased objective response rates and overall survival in multivariate analyses, independent of PD-L1 expression, antibiotics and performance status. Intestinal Akk was accompanied by a richer commensalism, including Eubacterium hallii and Bifidobacterium adolescentis and a more inflamed tumor microenvironment in a subset of patients. However, antibiotic use (20% of cases) coincided with a relative dominance of Akk above 4.8% accompanied with the genus Clostridium, both associated with resistance to ICI. Our study shows significant differences in relative abundance of Akk that could be useful for future studies as a tool to aid patient stratification.

Published
2022

39. Immune system and intestinal microbiota determine efficacy of androgen deprivation therapy against prostate cancer

Author

Terrisse, Safae, primary, Goubet, Anne-Gaelle, additional, Ueda, Kousuke, additional, Thomas, Andrew Maltez, additional, Quiniou, Valentin, additional, Thelemaque, Cassandra, additional, Dunsmore, Garett, additional, Clave, Emmanuel, additional, Gamat-Huber, Melissa, additional, Yonekura, Satoru, additional, Ferrere, Gladys, additional, Rauber, Conrad, additional, Pham, Hang Phuong, additional, Fahrner, Jean-Eudes, additional, Pizzato, Eugenie, additional, Ly, Pierre, additional, Fidelle, Marine, additional, Mazzenga, Marine, additional, Costa Silva, Carolina Alves, additional, Armanini, Federica, additional, Pinto, Federica, additional, Asnicar, Francesco, additional, Daillère, Romain, additional, Derosa, Lisa, additional, Richard, Corentin, additional, Blanchard, Pierre, additional, Routy, Bertrand, additional, Culine, Stéphane, additional, Opolon, Paule, additional, Silvin, Aymeric, additional, Ginhoux, Florent, additional, Toubert, Antoine, additional, Segata, Nicola, additional, McNeel, Douglas G, additional, Fizazi, Karim, additional, Kroemer, Guido, additional, and Zitvogel, Laurence, additional

Published
2022
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40. Circulating acetylated polyamines correlate with Covid-19 severity in cancer patients

Author

Bourgin, Mélanie, primary, Derosa, Lisa, additional, Silva, Carolina Alves Costa, additional, Goubet, Anne-Gaëlle, additional, Dubuisson, Agathe, additional, Danlos, François-Xavier, additional, Grajeda-Iglesias, Claudia, additional, Cerbone, Luigi, additional, Geraud, Arthur, additional, Laparra, Ariane, additional, Aprahamian, Fanny, additional, Nirmalathasan, Nitharsshini, additional, Madeo, Frank, additional, Zitvogel, Laurence, additional, Kroemer, Guido, additional, and Durand, Sylvère, additional

Published
2021
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41. Cancer induces a stress ileopathy depending on B-adrenergic receptors and promoting dysbiosis that contribute to carcinogenesis

Author

Yonekura, Satoru, Terrisse, Safae, Alves Costa Silva, Carolina, Lafarge, Antoine, Iebba, Valerio, Ferrere, Gladys, Goubet, Anne-Gaelle, Fahrner, Jean-Eudes, Lahmar, Imran, Ueda, Kosuke, Mansouri, Gibrail, Pizzato, Eugenie, Ly, Pierre, Mazzenga, Marine, Thelemaque, Cassandra, Fidelle, Marine, Jaulin, Fanny, Cartry, Jerome, Deloger, Marc, Aglave, Marine, Droin, Nathalie, Opolon, Paule, Puget, Angelique, Mann, Fanny, Neunlist, Michel, Bessard, Anne, Aymeric, Laetitia, Matysiak-Budnik, Tamara, Bosq, Jacques, Hofman, Paul, Duong, Connie P M, Ugolini, Sophie, Quiniou, Valentin, Berrard, Sylvie, Ryffel, Bernhard, Kepp, Oliver, Kroemer, Guido, Routy, Bertrand, Lordello, Leonardo, Bani, Mohamed-Amine, Segata, Nicola, Yousef Yengej, Fjodor, Clevers, Hans, Scoazec, Jean-Yves, Pasolli, Edoardo, Derosa, Lisa, Zitvogel, Laurence, Yonekura, Satoru, Terrisse, Safae, Alves Costa Silva, Carolina, Lafarge, Antoine, Iebba, Valerio, Ferrere, Gladys, Goubet, Anne-Gaelle, Fahrner, Jean-Eudes, Lahmar, Imran, Ueda, Kosuke, Mansouri, Gibrail, Pizzato, Eugenie, Ly, Pierre, Mazzenga, Marine, Thelemaque, Cassandra, Fidelle, Marine, Jaulin, Fanny, Cartry, Jerome, Deloger, Marc, Aglave, Marine, Droin, Nathalie, Opolon, Paule, Puget, Angelique, Mann, Fanny, Neunlist, Michel, Bessard, Anne, Aymeric, Laetitia, Matysiak-Budnik, Tamara, Bosq, Jacques, Hofman, Paul, Duong, Connie P M, Ugolini, Sophie, Quiniou, Valentin, Berrard, Sylvie, Ryffel, Bernhard, Kepp, Oliver, Kroemer, Guido, Routy, Bertrand, Lordello, Leonardo, Bani, Mohamed-Amine, Segata, Nicola, Yousef Yengej, Fjodor, Clevers, Hans, Scoazec, Jean-Yves, Pasolli, Edoardo, Derosa, Lisa, and Zitvogel, Laurence

Abstract

Gut dysbiosis has been associated with intestinal and extra-intestinal malignancies but whether and how carcinogenesis drives compositional shifts of the microbiome to its own benefit remains an open conundrum. Here we show that malignant processes can cause ileal mucosa atrophy, with villous microvascular constriction associated with dominance of sympathetic over cholinergic signaling. Rapid onset of tumorigenesis induced a burst of Reg3y release by ileal cells, and transient epithelial barrier permeability that culminated in overt and long lasting dysbiosis dominated by Gram positive Clostridium species. Pharmacological blockade of B-adrenergic receptors or genetic deficiency in Adrb2 gene, vancomycin or co-housing of tumor bearers with tumor free littermates prevented cancer-induced ileopathy, eventually slowing tumor growth kinetics. Cancer patients harbor distinct hallmarks of this stress ileopathy dominated by Clostridium species. Hence, stress ileopathy is a corollary disease of extra-intestinal malignancies requiring specific therapies.

Published
2021

42. Immunodynamics of explanted human tumors for immuno‐oncology

Author

Dubuisson, Agathe, Fahrner, Jean Eudes, Goubet, Anne Gaëlle, Terrisse, Safae A., Voisin, Nicolas, Bayard, Charles, Lofek, Sébastien, Drubay, Damien, Bredel, Delphine, Mouraud, Séverine, Susini, Sandrine, Cogdill, Alexandria P., Rebuffet, Lucas, Ballot, Elise, Jacquelot, Nicolas, Thomas de Montpreville, Vincent, Casiraghi, Odile, Radulescu, Camélia, Ferlicot, Sophie, Figueroa, David J., Yadavilli, Sapna, Waight, Jeremy D., Ballas, Marc S., Hoos, Axel X., Condamine, Thomas, Parier, Bastien, Gaudillat, Christophe, Routy, Bertrand, Ghiringhelli, François, Derosa, Lisa, Breuskin, Ingrid, Rouanne, Mathieu, André, Fabrice, Lebacle, Cédric, Baumert, Hervé, Wislez, Marie, Fadel, Élie, Cremer, Isabelle, Albiges, Laurence, Geoerger, Birgit, Scoazec, Jean Yves, Loriot, Yohann, Kroemer, Guido, Marabelle, Aurélien, Bonvalet, Mélodie, Zitvogel, Laurence, Immunologie des tumeurs et immunothérapie (UMR 1015), Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Gustave Roussy (IGR)-Université Paris-Sud - Paris 11 (UP11), Centre de recherche en épidémiologie et santé des populations (CESP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris-Sud - Paris 11 (UP11)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Service de biostatistique et d'épidémiologie (SBE), Direction de la recherche clinique [Gustave Roussy], Institut Gustave Roussy (IGR)-Institut Gustave Roussy (IGR), The University of Texas M.D. Anderson Cancer Center [Houston], Centre Régional de Lutte contre le cancer Georges-François Leclerc [Dijon] (UNICANCER/CRLCC-CGFL), UNICANCER, The Walter and Eliza Hall Institute of Medical Research (WEHI), Département de biologie et pathologie médicales [Gustave Roussy], Institut Gustave Roussy (IGR), Centre hospitalier Saint-Joseph [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre de Recherche du Centre Hospitalier de l’Université de Montréal (CR CHUM), Centre Hospitalier de l'Université de Montréal (CHUM), Université de Montréal (UdeM)-Université de Montréal (UdeM), Département de médecine oncologique [Gustave Roussy], Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Hôpital Foch [Suresnes], Direction de la recherche [Gustave Roussy], AP-HP - Hôpital Cochin Broca Hôtel Dieu [Paris], CHU Tenon [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre de Recherche des Cordeliers (CRC (UMR_S_1138 / U1138)), École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université de Paris (UP), Vectorologie et thérapeutiques anti-cancéreuses [Villejuif] (UMR 8203), Université Paris-Sud - Paris 11 (UP11)-Institut Gustave Roussy (IGR)-Centre National de la Recherche Scientifique (CNRS), Analyse moléculaire, modélisation et imagerie de la maladie cancéreuse (AMMICa), Institut Gustave Roussy (IGR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Karolinska University Hospital [Stockholm], Chancellerie des Universités de Paris Agence Nationale de la Recherche, ANR Seerave Foundation Association pour la Recherche sur le Cancer, ARC ANR‐16‐RHUS‐0008 Ligue Contre le Cancer European Commission, EC Fondation pour la Recherche Médicale, FRM Institut National Du Cancer, INCa Institut Universitaire de France, IUF European Research Council, ERC Fondation Leducq RP170067 Association pour la Recherche sur le Cancer, ARC, LZ and GK were supported by the Ligue contre le Cancer (équipe labelisée), Agence Nationale de la Recherche (ANR) francogermanique ANR‐19‐CE15‐0029, ANR Projects blancs, ANR under the frame of E‐Rare‐2, the ERA‐Net for Research on Rare Diseases, Association pour la recherche sur le cancer (ARC), Bristol‐Myers Squibb Company (International Immuno‐Oncology Network), Cancéropôle Ile‐de‐France, Chancellerie des universités de Paris (Legs Poix), Fondation pour la Recherche Médicale (FRM), a donation by Elior, the European Commission (ArtForce), the European Research Council (ERC), Fondation Carrefour, Institut National du Cancer (INCa), Inserm (HTE), Institut Universitaire de France, LeDucq Foundation, the LabEx Immuno‐Oncology, the RHU Torino Lumière (ANR‐16‐RHUS‐0008), H2020 ONCOBIOME, the Seerave Foundation, the SIRIC Stratified Oncology Cell DNA Repair and Tumor Immune Elimination (SOCRATE), FHU CARE, Dassault, and Badinter Philantropia, and the Paris Alliance of Cancer Research Institutes (PACRI). AC is supported by the CPRIT Research Training Program (RP170067). JEF was supported by Transgene and AGG was supported by FRM. AM has been or is currently an investigator in clinical trials sponsored by BMS, MSD, GSK/Tesaro, Janssen, Roche/Genentech, Pfizer, Astra Zeneca (AZ), Amgen. AM has been or is currently a member of Clinical Trial Scientific Steering Committee for AZ and GSK. AM has been or is currently a member of the scientific advisory board of the following companies: Merck Serono, Novartis, BMS, Symphogen, Amgen, Tesaro/GSK, Pfizer, Astra Zeneca/Medimmune, Servier, Sanofi. AM has provided Scientific & Medical Consulting to the following companies: Roche, Sanofi. AM is a member of the Data Safety and Monitoring Board for the following trial NCT02423863 (TLR3 agonist, Oncovir). AM has received research funding and or drug supply for pre‐Clinical and clinical research projects from: BMS, Boehringer Ingelheim, Idera, MSD, Fondation MSD Avenir, SIRIC (INCa‐DGOS‐Inserm_12551)., ANR-16-RHUS-0008,LUMIERE,LUMIERE(2016), Université Paris-Sud - Paris 11 (UP11)-Institut Gustave Roussy (IGR)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM), and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université Paris Cité (UPC)

Subjects
Medicine (General), [SDV]Life Sciences [q-bio], Immunology, QH426-470, Medical Oncology, immune checkpoint inhibitors, R5-920, immunomonitoring, Report, precision oncology, Neoplasms, Genetics, “in sitro” assay, Tumor Microenvironment, cancer, Humans, Immunotherapy, Prospective Studies, Reports
Abstract

Decision making in immuno‐oncology is pivotal to adapt therapy to the tumor microenvironment (TME) of the patient among the numerous options of monoclonal antibodies or small molecules. Predicting the best combinatorial regimen remains an unmet medical need. Here, we report a multiplex functional and dynamic immuno‐assay based on the capacity of the TME to respond to ex vivo stimulation with twelve immunomodulators including immune checkpoint inhibitors (ICI) in 43 human primary tumors. This "in sitro" (in situ/in vitro) assay has the potential to predict unresponsiveness to anti‐PD‐1 mAbs, and to detect the most appropriate and personalized combinatorial regimen. Prospective clinical trials are awaited to validate this in sitro assay., To predict cancer resistance to PD‐1 blockade and design suitable combinations of immunomodulators, a 60‐h functional in sitro assay was set up in 43 tumors that allowed calculation of the “Immune Reactivity Score (IRS)” based on 17 TCR‐dependent‐ cytokines/chemokines.

Published
2020
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43. Cross-reactivity between tumor MHC class I-restricted antigens and an enterococcal bacteriophage

Author

Fluckiger, Aurelie, Daillere, Romain, Sassi, Mohamed, Sixt, Barbara Susanne, Liu, Peng, Loos, Friedemann, Richard, Corentin, Rabu, Catherine, Alou, Maryam Tidjani, Goubet, Anne-Gaelle, Lemaitre, Fabien, Ferrere, Gladys, Derosa, Lisa, Duong, Connie P. M., Messaoudene, Meriem, Gagne, Andreanne, Joubert, Philippe, De Sordi, Luisa, Debarbieux, Laurent, Simon, Sylvain, Scarlata, Clara-Maria, Ayyoub, Maha, Palermo, Belinda, Facciolo, Francesco, Boidot, Romain, Wheeler, Richard, Boneca, Ivo Gomperts, Sztupinszki, Zsofia, Papp, Krisztian, Csabai, Istvan, Pasolli, Edoardo, Segata, Nicola, Lopez-Otin, Carlos, Szallasi, Zoltan, Andre, Fabrice, Iebba, Valerio, Quiniou, Valentin, Klatzmann, David, Boukhalil, Jacques, Khelaifia, Saber, Raoult, Didier, Albiges, Laurence, Escudier, Bernard, Eggermont, Alexander, Mami-Chouaib, Fathia, Nistico, Paola, Ghiringhelli, Francois, Routy, Bertrand, Labarriere, Nathalie, Cattoir, Vincent, Kroemer, Guido, Zitvogel, Laurence, Fluckiger, Aurelie, Daillere, Romain, Sassi, Mohamed, Sixt, Barbara Susanne, Liu, Peng, Loos, Friedemann, Richard, Corentin, Rabu, Catherine, Alou, Maryam Tidjani, Goubet, Anne-Gaelle, Lemaitre, Fabien, Ferrere, Gladys, Derosa, Lisa, Duong, Connie P. M., Messaoudene, Meriem, Gagne, Andreanne, Joubert, Philippe, De Sordi, Luisa, Debarbieux, Laurent, Simon, Sylvain, Scarlata, Clara-Maria, Ayyoub, Maha, Palermo, Belinda, Facciolo, Francesco, Boidot, Romain, Wheeler, Richard, Boneca, Ivo Gomperts, Sztupinszki, Zsofia, Papp, Krisztian, Csabai, Istvan, Pasolli, Edoardo, Segata, Nicola, Lopez-Otin, Carlos, Szallasi, Zoltan, Andre, Fabrice, Iebba, Valerio, Quiniou, Valentin, Klatzmann, David, Boukhalil, Jacques, Khelaifia, Saber, Raoult, Didier, Albiges, Laurence, Escudier, Bernard, Eggermont, Alexander, Mami-Chouaib, Fathia, Nistico, Paola, Ghiringhelli, Francois, Routy, Bertrand, Labarriere, Nathalie, Cattoir, Vincent, Kroemer, Guido, and Zitvogel, Laurence

Abstract

Intestinal microbiota have been proposed to induce commensal-specific memory T cells that cross-react with tumor-associated antigens. We identified major histocompatibility complex (MHC) class I-binding epitopes in the tail length tape measure protein (TMP) of a prophage found in the genome of the bacteriophage Enterococcus hirae. Mice bearing E. hirae harboring this prophage mounted a TMP-specific H-2K(b)-restricted CD8(+) T lymphocyte response upon immunotherapy with cyclophosphamide or anti-PD-1 antibodies. Administration of bacterial strains engineered to express the TMP epitope improved immunotherapy in mice. In renal and lung cancer patients, the presence of the enterococcal prophage in stools and expression of a TMP-cross-reactive antigen by tumors correlated with long-term benefit of PD-1 blockade therapy. In melanoma patients, T cell clones recognizing naturally processed cancer antigens that are cross-reactive with microbial peptides were detected.

Published
2020
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44. Oral administration of Akkermansia muciniphila elevates systemic antiaging and anticancer metabolites

Author

Grajeda-Iglesias, Claudia, primary, Durand, Sylvère, additional, Daillère, Romain, additional, Iribarren, Kristina, additional, Lemaitre, Fabien, additional, Derosa, Lisa, additional, Aprahamian, Fanny, additional, Bossut, Noélie, additional, Nirmalathasan, Nitharsshini, additional, Madeo, Frank, additional, Zitvogel, Laurence, additional, and Kroemer, Guido, additional

Published
2021
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45. Ketogenic diet and ketone bodies enhance the anticancer effects of PD-1 blockade

Author

Ferrere, Gladys, primary, Tidjani Alou, Maryam, additional, Liu, Peng, additional, Goubet, Anne-Gaëlle, additional, Fidelle, Marine, additional, Kepp, Oliver, additional, Durand, Sylvère, additional, Iebba, Valerio, additional, Fluckiger, Aurélie, additional, Daillère, Romain, additional, Thelemaque, Cassandra, additional, Grajeda-Iglesias, Claudia, additional, Alves Costa Silva, Carolina, additional, Aprahamian, Fanny, additional, Lefevre, Déborah, additional, Zhao, Liwei, additional, Ryffel, Bernhard, additional, Colomba, Emeline, additional, Arnedos, Monica, additional, Drubay, Damien, additional, Rauber, Conrad, additional, Raoult, Didier, additional, Asnicar, Francesco, additional, Spector, Tim, additional, Segata, Nicola, additional, Derosa, Lisa, additional, Kroemer, Guido, additional, and Zitvogel, Laurence, additional

Published
2021
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46. Identification of international metastatic renal cell carcinoma database consortium (IMDC) intermediate-risk subgroups in patients with metastatic clear-cell renal cell carcinoma

Author

Guida, Annalisa, primary, Le Teuff, Gwénaël, additional, Alves, Carolina, additional, Colomba, Emeline, additional, Di Nunno, Vincenzo, additional, Derosa, Lisa, additional, Flippot, Ronan, additional, Escudier, Bernard, additional, and Albiges, Laurence, additional

Published
2020
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49. Elucidating the gut microbiota composition and the bioactivity of immunostimulatory commensals for the optimization of immune checkpoint inhibitors

Author

Daillère, Romain, primary, Routy, Bertrand, additional, Goubet, Anne-Gaëlle, additional, Cogdill, Alexandria, additional, Ferrere, Gladys, additional, Alves-Costa Silva, Carolina, additional, Fluckiger, Aurélie, additional, Ly, Pierre, additional, Haddad, Yacine, additional, Pizzato, Eugenie, additional, Thelemaque, Cassandra, additional, Fidelle, Marine, additional, Mazzenga, Marine, additional, Roberti, Maria Paula, additional, Melenotte, Cléa, additional, Liu, Peng, additional, Terrisse, Safae, additional, Kepp, Oliver, additional, Kroemer, Guido, additional, Zitvogel, Laurence, additional, and Derosa, Lisa, additional

Published
2020
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50. Trial watch : the gut microbiota as a tool to boost the clinical efficacy of anticancer immunotherapy

Author

Daillère, Romain, primary, Derosa, Lisa, additional, Bonvalet, Mélodie, additional, Segata, Nicola, additional, Routy, Bertrand, additional, Gariboldi, Manuela, additional, Budinská, Eva, additional, De Vries, I. Jolanda M., additional, Naccarati, Alessio Gordon, additional, Zitvogel, Valérie, additional, Caldas, Carlos, additional, Engstrand, Lars, additional, Loibl, Sibylle, additional, Fieschi, Jacques, additional, Heinzerling, Lucie, additional, Kroemer, Guido, additional, and Zitvogel, Laurence, additional

Published
2020
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