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4. Modulation of behavioral and neurochemical responses of adult zebrafish by fluoxetine, eicosapentaenoic acid and lipopolysaccharide in the prolonged chronic unpredictable stress model

Author

Demin, Konstantin A., Kolesnikova, Tatiana O., Galstyan, David S., Krotova, Nataliya A., Ilyin, Nikita P., Derzhavina, Ksenia A., Levchenko, Nataliia A., Strekalova, Tatyana, de Abreu, Murilo S., Petersen, Elena V., Seredinskaya, Maria, Cherneyko, Yulia V., Kositsyn, Yuriy M., Sorokin, Dmitry V., Zabegalov, Konstantin N., Mor, Mikael S., Efimova, Evgeniya V., and Kalueff, Allan V.

Published
2021
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7. Understanding complex dynamics of behavioral, neurochemical and transcriptomic changes induced by prolonged chronic unpredictable stress in zebrafish

Author

Demin, Konstantin A., Lakstygal, Anton M., Krotova, Nataliya A., Masharsky, Alexey, Tagawa, Natsuki, Chernysh, Maria V., Ilyin, Nikita P., Taranov, Alexander S., Galstyan, David S., Derzhavina, Ksenia A., Levchenko, Nataliia A., Kolesnikova, Tatiana O., Mor, Mikael S., Vasyutina, Marina L., Efimova, Evgeniya V., Katolikova, Nataliia, Prjibelski, Andrey D., Gainetdinov, Raul R., de Abreu, Murilo S., Amstislavskaya, Tamara G., Strekalova, Tatyana, and Kalueff, Allan V.

Published
2020
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10. Understanding CNS Effects of Antimicrobial Drugs Using Zebrafish Models

Author

Kotova, Maria M., primary, Galstyan, David S., additional, Kolesnikova, Tatiana O., additional, de Abreu, Murilo S., additional, Amstislavskaya, Tamara G., additional, Strekalova, Tatyana, additional, Petersen, Elena V., additional, Yenkoyan, Konstantin B., additional, Demin, Konstantin A., additional, and Kalueff, Allan V., additional

Published
2023
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11. Developing Novel Experimental Models of m-TORopathic Epilepsy and Related Neuropathologies: Translational Insights from Zebrafish

Author

de Abreu, Murilo S., primary, Demin, Konstantin A., additional, Kotova, Maria M., additional, Mirzaei, Foad, additional, Shariff, Sanobar, additional, Kantawala, Burhan, additional, Zakharchenko, Ksenia V., additional, Kolesnikova, Tatiana O., additional, Dilbaryan, Karen, additional, Grigoryan, Artem, additional, Yenkoyan, Konstantin B., additional, and Kalueff, Allan V., additional

Published
2023
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12. Study of Co-Deposition of Tantalum and Titanium during the Formation of Layered Composite Materials by Magnetron Sputtering

Author

Nasakina, Elena Olegovna, primary, Sudarchikova, Maria Andreevna, additional, Demin, Konstantin Yurievich, additional, Mikhailova, Alexandra Borisovna, additional, Sergienko, Konstantin Vladimirovich, additional, Konushkin, Sergey Viktorovich, additional, Kaplan, Mikhail Alexandrovich, additional, Baikin, Alexander Sergeevich, additional, Sevostyanov, Mikhail Anatolyevich, additional, and Kolmakov, Alexei Georgievich, additional

Published
2023
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13. Investigation of Antibacterial Properties of Corrosion-Resistant 316L Steel Alloyed with 0.2 wt.% and 0.5 wt.% Ag

Author

Kaplan, Mikhail A., primary, Gorbenko, Artem D., additional, Ivannikov, Alexander Y., additional, Kartabaeva, Bakhyt B., additional, Konushkin, Sergey V., additional, Demin, Konstantin Y., additional, Baikin, Alexander S., additional, Sergienko, Konstantin V., additional, Nasakina, Elena O., additional, Bannykh, Igor O., additional, Gorudko, Irina V., additional, Kolmakov, Alexey G., additional, Simakin, Alexander V., additional, Gudkov, Sergey V., additional, Glinushkin, Alexey P., additional, and Sevostyanov, Mikhail A., additional

Published
2022
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14. Diversity and Metabolic Potential of a PAH-Degrading Bacterial Consortium in Technogenically Contaminated Haplic Chernozem, Southern Russia

Author

Delegan, Yanina, primary, Sushkova, Svetlana, additional, Minkina, Tatiana, additional, Filonov, Andrey, additional, Kocharovskaya, Yulia, additional, Demin, Konstantin, additional, Gorovtsov, Andrey, additional, Rajput, Vishnu D., additional, Zamulina, Inna, additional, Grigoryeva, Tatiana, additional, Dudnikova, Tamara, additional, Barbashev, Andrey, additional, and Maksimov, Aleksey, additional

Published
2022
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15. Enhanced Aggression, Reduced Self-Grooming Behavior and Altered 5-HT Regulation in the Frontal Cortex in Mice Lacking Trace Amine-Associated Receptor 1 (TAAR1)

Author

Zhukov, Ilya S., primary, Karpova, Inessa V., additional, Krotova, Nataliya A., additional, Tissen, Ilya Y., additional, Demin, Konstantin A., additional, Shabanov, Petr D., additional, Budygin, Evgeny A., additional, Kalueff, Allan V., additional, and Gainetdinov, Raul R., additional

Published
2022
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16. Towards Zebrafish Models of CNS Channelopathies

Author

Kolesnikova, Tatiana O., primary, Demin, Konstantin A., additional, Costa, Fabiano V., additional, Zabegalov, Konstantin N., additional, de Abreu, Murilo S., additional, Gerasimova, Elena V., additional, and Kalueff, Allan V., additional

Published
2022
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18. Towards modeling anhedonia and its treatment in zebrafish

Author

S. de Abreu, Murilo, primary, Costa, Fabiano, additional, Giacomini, Ana C V V, additional, Demin, Konstantin A, additional, Zabegalov, Konstantin N, additional, Maslov, Gleb O, additional, Kositsyn, Yuriy M, additional, Petersen, Elena V, additional, Strekalova, Tatiana, additional, Rosemberg, Denis B, additional, and Kalueff, Allan V, additional

Published
2021
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20. Investigation of Antibacterial Properties of Corrosion-Resistant 316L Steel Alloyed with 0.2 wt.% and 0.5 wt.% Ag.

Author

Kaplan, Mikhail A., Gorbenko, Artem D., Ivannikov, Alexander Y., Kartabaeva, Bakhyt B., Konushkin, Sergey V., Demin, Konstantin Y., Baikin, Alexander S., Sergienko, Konstantin V., Nasakina, Elena O., Bannykh, Igor O., Gorudko, Irina V., Kolmakov, Alexey G., Simakin, Alexander V., Gudkov, Sergey V., Glinushkin, Alexey P., and Sevostyanov, Mikhail A.

Subjects
PHYTOPATHOGENIC bacteria, STEEL alloys, X-ray spectroscopy, ERWINIA carotovora, XANTHOMONAS campestris, POWDERS, INGOTS
Abstract

The article is devoted to the study of melted ingots, plates rolled from them, and the resulting spherical powder made of corrosion-resistant 316L steel with the addition of 0.2 wt.% and 0.5 wt.% Ag. The study of antibacterial properties, microstructure, and distribution of silver concentrations, as well as qualitative analysis of silver content was carried out. The optimal mode of homogenization annealing of the ingot was 1050 °C for 9 h, which leads to the formation of an austenitic structure. It is shown that the addition of a small amount of silver does not affect the formation of the austenitic structure and silver is distributed evenly throughout the volume of the ingot. The austenitic structure also prevails in the plates after rolling. Silver is distributed evenly throughout the entire volume of the plate. It is noted that the addition of 0.2 wt.% Ag does not affect the strength, elongation, and microhardness of steel, and the addition of 0.5 wt.% Ag does not significantly reduce the strength of steel, however, all samples meet the mechanical characteristics according to the ASTM A240 standard. The qualitative chemical composition of samples made of corrosion-resistant steels was confirmed by X-ray fluorescence analysis methods. By the method of energy-dispersion analysis, the presence of a uniform distribution of silver over the entire volume of the powder particle was determined. The particles have a spherical shape with a minimum number of defects. The study of the antibacterial activity of plates and powder shows the presence of a clear antibacterial effect (bacteria of the genus Xanthomonas campestris, Erwinia carotovora, Pseudomonas marginalis, Clavibacter michiganensis) in samples No. 2 and No. 3 with the addition of 0.2 wt.% and 0.5 wt.% Ag. [ABSTRACT FROM AUTHOR]

Published
2023
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22. Cross-species analyses of intra-species behavioral differences in mammals and fish

Author

11083417 - Harvey, Brian Herbert, Demin, Konstantin A., Harvey, Brian Herbert, Lakstygal, Anton M., Volgin, Andrey D., De Abreu, Murilo S., 11083417 - Harvey, Brian Herbert, Demin, Konstantin A., Harvey, Brian Herbert, Lakstygal, Anton M., Volgin, Andrey D., and De Abreu, Murilo S.

Abstract

Multiple species display robust behavioral variance among individuals due to different genetic, genomic, epigenetic, neuroplasticity and environmental factors. Behavioral individuality has been extensively studied in various animal models, including rodents and other mammals. Fish, such as zebrafish (Danio rerio), have recently emerged as powerful aquatic model organisms with overt individual differences in behavioral, nociceptive and other CNS traits. Here, we evaluate individual behavioral differences in mammals and fish, emphasizing the importance of cross-species analyses of intraspecies variance in experimental models of normal and pathological CNS functions

Published
2020

23. Towards Modeling Anhedonia and Its Treatment in Zebrafish.

Author

Abreu, Murilo S de, Costa, Fabiano, Giacomini, Ana C V V, Demin, Konstantin A, Zabegalov, Konstantin N, Maslov, Gleb O, Kositsyn, Yuriy M, Petersen, Elena V, Strekalova, Tatiana, Rosemberg, Denis B, and Kalueff, Allan V

Subjects
ANHEDONIA, BRACHYDANIO, AFFECTIVE disorders, ZEBRA danio, MENTAL depression, LABORATORY animals
Abstract

Mood disorders, especially depression, are a major cause of human disability. The loss of pleasure (anhedonia) is a common, severely debilitating symptom of clinical depression. Experimental animal models are widely used to better understand depression pathogenesis and to develop novel antidepressant therapies. In rodents, various experimental models of anhedonia have already been developed and extensively validated. Complementing rodent studies, the zebrafish (Danio rerio) is emerging as a powerful model organism to assess pathobiological mechanisms of affective disorders, including depression. Here, we critically discuss the potential of zebrafish for modeling anhedonia and studying its molecular mechanisms and translational implications. [ABSTRACT FROM AUTHOR]

Published
2022
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24. The role of intraspecies variation in fish neurobehavioral and neuropharmacological phenotypes in aquatic models

Author

Demin, Konstantin A., primary, Lakstygal, Anton M., additional, Alekseeva, Polina A., additional, Sysoev, Maxim, additional, de Abreu, Murilo S., additional, Alpyshov, Erik T., additional, Serikuly, Nazar, additional, Wang, DongMei, additional, Wang, MengYao, additional, Tang, ZhiChong, additional, Yan, DongNi, additional, Strekalova, Tatyana V., additional, Volgin, Andrey D., additional, Amstislavskaya, Tamara G., additional, Wang, JiaJia, additional, Song, Cai, additional, and Kalueff, Allan V., additional

Published
2019
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25. Exploring CNS Effects of American Traditional Medicines using ZebrafishModels

Author

de Abreu, Murilo S., Costa, Fabiano, Giacomini, Ana C.V.V., Demin, Konstantin A., Petersen, Elena V., Rosemberg, Denis B., and Kalueff, Allan V.

Abstract

Although American traditional medicine (ATM) has been practiced for millennia, itscomplex multi-target mechanisms of therapeutic action remain poorly understood. Animal modelsare widely used to elucidate the therapeutic effects of various ATMs, including their modulation ofbrain and behavior. Complementing rodent models, the zebrafish (Danio rerio) is a promising novelorganism in translational neuroscience and neuropharmacology research. Here, we emphasize thegrowing value of zebrafish for testing neurotropic effects of ATMs and outline future directions ofresearch in this field. We also demonstrate the developing utility of zebrafish as complementarymodels for probing CNS mechanisms of ATM action and their potential to treat brain disorders.

Published
2022
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28. Animal inflammation-based models of depression and their application to drug discovery

Author

Ma, Li, Demin, Konstantin A., Kolesnikova, Tatyana O., Kharsko, Sergey L., Xiaokang Zhu, Xiaodong Yuan, Song, Cai, Meshalkina, Darya A., Leonard, Brian E., Tian, Li, and Kalueff, Allan V.

Subjects
3. Good health
Abstract

Introduction: Depression, anxiety and other affective disorders are globally widespread and severely debilitating human brain diseases. Despite their high prevalence and mental health impact, affective pathogenesis is poorly understood, and often remains recurrent and resistant to treatment. The lack of efficient antidepressants and presently limited conceptual innovation necessitate novel approaches and new drug targets in the field of antidepressant therapy. Areas covered: Herein, the authors discuss the emerging role of neuro-immune interactions in affective pathogenesis, which can become useful targets for CNS drug discovery, including modulating neuroinflammatory pathways to alleviate affective pathogenesis. Expert opinion: Mounting evidence implicates microglia, polyunsaturated fatty acids (PUFAs), glucocorticoids and gut microbiota in both inflammation and depression. It is suggested that novel antidepressants can be developed based on targeting microglia-, PUFAs-, glucocorticoid- and gut microbiota-mediated cellular pathways. In addition, the authors call for a wider application of novel model organisms, such as zebrafish, in studying shared, evolutionarily conserved (and therefore, core) neuro-immune mechanisms of depression.

29. Animal inflammation-based models of depression and their application to drug discovery

Author

Ma, Li, Demin, Konstantin A., Kolesnikova, Tatyana O., Kharsko, Sergey L., Xiaokang Zhu, Xiaodong Yuan, Song, Cai, Meshalkina, Darya A., Leonard, Brian E., Tian, Li, and Kalueff, Allan V.

Subjects
3. Good health
Abstract

Introduction: Depression, anxiety and other affective disorders are globally widespread and severely debilitating human brain diseases. Despite their high prevalence and mental health impact, affective pathogenesis is poorly understood, and often remains recurrent and resistant to treatment. The lack of efficient antidepressants and presently limited conceptual innovation necessitate novel approaches and new drug targets in the field of antidepressant therapy. Areas covered: Herein, the authors discuss the emerging role of neuro-immune interactions in affective pathogenesis, which can become useful targets for CNS drug discovery, including modulating neuroinflammatory pathways to alleviate affective pathogenesis. Expert opinion: Mounting evidence implicates microglia, polyunsaturated fatty acids (PUFAs), glucocorticoids and gut microbiota in both inflammation and depression. It is suggested that novel antidepressants can be developed based on targeting microglia-, PUFAs-, glucocorticoid- and gut microbiota-mediated cellular pathways. In addition, the authors call for a wider application of novel model organisms, such as zebrafish, in studying shared, evolutionarily conserved (and therefore, core) neuro-immune mechanisms of depression.

30. Towards Modeling Anhedonia and Its Treatment in Zebrafish.

Author

de Abreu MS, Costa F, Giacomini ACVV, Demin KA, Zabegalov KN, Maslov GO, Kositsyn YM, Petersen EV, Strekalova T, Rosemberg DB, and Kalueff AV

Subjects
Animals, Antidepressive Agents pharmacology, Antidepressive Agents therapeutic use, Behavior, Animal, Disease Models, Animal, Anhedonia, Zebrafish
Abstract

Mood disorders, especially depression, are a major cause of human disability. The loss of pleasure (anhedonia) is a common, severely debilitating symptom of clinical depression. Experimental animal models are widely used to better understand depression pathogenesis and to develop novel antidepressant therapies. In rodents, various experimental models of anhedonia have already been developed and extensively validated. Complementing rodent studies, the zebrafish (Danio rerio) is emerging as a powerful model organism to assess pathobiological mechanisms of affective disorders, including depression. Here, we critically discuss the potential of zebrafish for modeling anhedonia and studying its molecular mechanisms and translational implications., (© The Author(s) 2021. Published by Oxford University Press on behalf of CINP.)

Published
2022
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