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3. Tumor sequencing of African ancestry reveals differences in clinically relevant alterations across common cancers

Author

Jiagge, Evelyn, Jin, Dexter X., Newberg, Justin Y., Perea-Chamblee, Tomin, Pekala, Kelly R., Fong, Christopher, Waters, Michele, Ma, David, Dei-Adomakoh, Yvonne, Erb, Gilles, Arora, Kanika S., Maund, Sophia L., Njiraini, Njoki, Ntekim, Atara, Kim, Susie, Bai, Xuechun, Thomas, Marlene, van Eeden, Ronwyn, Hegde, Priti, Jee, Justin, Chakravarty, Debyani, Schultz, Nikolaus, Berger, Michael F., Frampton, Garrett M., Sokol, Ethan S., and Carrot-Zhang, Jian

Published
2023
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7. Sickle Cell Hemoglobin Genotypes Affect Malaria Parasite Growth and Correlate with Exosomal miR-451a and let-7i-5p Levels

Author

Oxendine Harp, Keri, primary, Bashi, Alaijah, additional, Botchway, Felix, additional, Addo-Gyan, Daniel, additional, Tetteh-Tsifoanya, Mark, additional, Lamptey, Amanda, additional, Djameh, Georgina, additional, Iqbal, Shareen A., additional, Lekpor, Cecilia, additional, Banerjee, Saswati, additional, Wilson, Michael D., additional, Dei-Adomakoh, Yvonne, additional, Adjei, Andrew A., additional, Stiles, Jonathan K., additional, and Driss, Adel, additional

Published
2023
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8. Cervical precancer screening with HPV DNA testing and mobile colposcopy in women with sickle cell disease in Accra, Ghana.

Author

Dei-Adomakoh, Yvonne, Effah, Kofi, Tekpor, Ethel, Crabbe, Selina, Amuah, Joseph Emmanuel, Wormenor, Comfort Mawusi, Tay, Georgina, Asare, Eugenia Vicky, Kemawor, Seyram, Danyo, Stephen, Morkli, Esu Aku Catherine, Tibu, Faustina, Essel, Nana Owusu, and Akakpo, Patrick Kafui

Subjects
*SICKLE cell anemia, *MEDICAL screening, *MOBILE genetic elements, *COLPOSCOPY, *HUMAN papillomavirus, *CERVICAL intraepithelial neoplasia, *PARITY (Obstetrics), *HOME accidents
Abstract

Background: Worldwide, about 20-25 million people are affected by sickle cell disease (SCD), with 60% of patients living in sub-Saharan Africa. Despite recent therapeutic advancements resulting in improved life expectancy among SCD patients, the prevalence of high-risk human papillomavirus (hr-HPV) and cervical lesions have not been studied in women with SCD. We determined the prevalence of hr-HPV and cervical lesions among women with SCD and recommended strategies for reducing cervical cancer incidence in this cohort. Methods: Through the mPharma 10,000 Women Initiative, women with SCD attending routine visits at the Ghana Institute of Clinical Genetics SCD clinic were screened by trained nurses. Screening was performed via concurrent MA-6000 hr-HPV DNA testing and enhanced visual assessment (EVA) mobile colposcopy from mobileODT. Results: Among 168 participants screened (mean age, 43.0 years), the overall prevalence rates of hr-HPV infection and cervical lesions were 28.6% (95% CI, 21.7-35.4) and 3.6% (95% CI, 0.8-6.4), respectively. The hr-HPV prevalence rates stratified by haemoglobin genotype were 29.4% (95% CI, 19.7-39.1) and 28.6% (95% CI, 18.5-38.7) for genotypes SS and SC, respectively. None of the five women with the SF genotype tested hr-HPV positive, and the only patient with Sbthal genotype tested hr-HPV positive. Two women were EVA 'positive' but hr-HPV negative, whereas four were EVA positive and hr-HPV positive. Exploratory analysis revealed no significant associations between hr-HPV positivity and age, education level, marital status or parity. Conclusion: In the absence of a comprehensive national cervical screening programme aimed at including women with SCD as a special population, cervical cancer may increase in frequency among SCD patients. Thus, there is a need to build capacity and expand the scope of screening services for women with SCD. [ABSTRACT FROM AUTHOR]

Published
2023
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10. Implementation of multidisciplinary care reduces maternal mortality in women with sickle cell disease living in low‐resource setting

Author

Asare, Eugenia Vicky, Olayemi, Edeghonghon, Boafor, Theodore, Dei‐Adomakoh, Yvonne, Mensah, Enoch, Ghansah, Harriet, Osei‐Bonsu, Yvonne, Crabbe, Selina, Musah, Latif, Hayfron‐Benjamin, Charles, Covert, Brittany, Kassim, Adetola A., James, Andra, Rodeghier, Mark, DeBaun, Michael R., and Oppong, Samuel A.

Published
2017
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13. Additional file 1 of Rational design of an essential diagnostics network to support Universal Health Coverage: a modeling analysis

Author

Schroeder, Lee F., Dei-Adomakoh, Yvonne, DeStigter, Kristen, Idigbe, Emmanuel O., Flanigan, John, Ekpale, Priscilla Mawuli Awo, Adjei, Ernest, Roa, Lina, Wilson, Michael L., and Horton, Susan

Abstract

Additional file 1: Supplementary Figure S1. Cumulative Number of Diagnostics with Additional Diseases. Supplementary Table S1. Definitions of disease levels (uncomplicated vs complicated). Supplementary Table S2. Mapping of medicines to disease levels. Supplementary Table S3. Mapping of diagnostics to disease levels. Supplementary Table S4. Mapping of diagnostics to diagnostic formats. Supplementary Table S5. Infrastructural limitations of diagnostic formats. Supplementary Table S6. Model output of diagnostics by health facility tier. Supplementary Table S7. Minimum equipment investment and workforce skill needs, by health system tier.

Published
2022
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16. Low FEV1 is associated with fetal death in pregnant women with sickle cell disease

Author

Hayfron‐Benjamin, Charles F., primary, Asare, Eugenia Vicky, additional, Boafor, Theodore, additional, Olayemi, Edeghonghon, additional, Dei‐Adomakoh, Yvonne, additional, Musah, Latif, additional, Mensah, Enoch, additional, Beyuo, Titus, additional, Kassim, Adetola A., additional, Rodeghier, Mark, additional, DeBaun, Michael R., additional, and Oppong, Samuel A., additional

Published
2021
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21. Landscape of Oncology Clinical Trials in Africa

Author

Odedina, Folakemi T., primary, Shamley, Delva, additional, Okoye, Ifeoma, additional, Ezeani, Adaora, additional, Ndlovu, Ntokozo, additional, Dei-Adomakoh, Yvonne, additional, Meza, Kimberly, additional, Agaba, Ruth, additional, Fathi, Parisa, additional, and Askins, Nissa, additional

Published
2020
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23. Third trimester and early postpartum period of pregnancy have the greatest risk for ACS in women with SCD

Author

Asare, Eugenia Vicky, primary, Olayemi, Edeghonghon, additional, Boafor, Theodore, additional, Dei‐Adomakoh, Yvonne, additional, Mensah Dip, Enoch, additional, Benjamin, Charles Hayfron, additional, Covert, Brittany, additional, Kassim, Adetola A., additional, James, Andra, additional, Rodeghier, Mark, additional, DeBaun, Michael R., additional, and Oppong, Samuel A., additional

Published
2019
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27. Multidisciplinary care results in similar maternal and perinatal mortality rates for women with and without SCD in a low-resource setting

Author

Oppong, Samuel A., primary, Asare, Eugenia V., additional, Olayemi, Edeghonghon, additional, Boafor, Theodore, additional, Dei-Adomakoh, Yvonne, additional, Swarry-Deen, Alim, additional, Mensah, Enoch, additional, Osei-Bonsu, Yvonne, additional, Crabbe, Selina, additional, Musah, Latif, additional, Hayfron-Benjamin, Charles, additional, Covert, Brittany, additional, Kassim, Adetola A., additional, James, Andra, additional, Rodeghier, Mark, additional, Audet, Carolyn, additional, and DeBaun, Michael R., additional

Published
2018
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29. Bleomycin-induced pneumonitis in a young Ghanaian male with Hodgkin's Lymphoma.

Author

Dei-Adomakoh, Yvonne A., Afriyie-Mensah, Jane S., and Gbadamosi, Hafisatu

Subjects
*HODGKIN'S disease, *SUDDEN onset of disease, *PULMONARY fibrosis, *PNEUMONIA, *GERM cell tumors, *GHANAIANS
Abstract

We report a case of a young Ghanaian male who developed Bleomycin Induced Pneumonitis (BIP) after being treated for Hodgkin's Lymphoma. Pulmonary toxicity is the most feared complication of bleomycin therapy despite its effectiveness in achieving cure in patients with Hodgkin's lymphoma and germ cell tumors. BIP has a significant mortality rate if detected late and a high index of suspicion is required in all patients on bleomycin-based therapies with sudden onset of respiratory symptoms. [ABSTRACT FROM AUTHOR]

Published
2020
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30. A case series describing causes of death in pregnant women with sickle cell disease in a low-resource setting

Author

Asare, Eugenia Vicky, primary, Olayemi, Edeghonghon, additional, Boafor, Theodore, additional, Dei-Adomakoh, Yvonne, additional, Mensah, Enoch, additional, Osei-Bonsu, Yvonne, additional, Crabbe, Selina, additional, Musah, Latif, additional, Hayfron-Benjamin, Charles, additional, Covert-Greene, Brittany, additional, Kassim, Adetola A., additional, James, Andra, additional, Rodeghier, Mark, additional, DeBaun, Michael R., additional, and Oppong, Samuel A., additional

Published
2018
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32. Presentation and survival of multiple myeloma patients in Ghana: a review of 169 cases.

Author

Acquah, Michael E., Hsing, Ann W., McGuire, Valerie, Wang, Sophia, Birmann, Brenda, and Dei-Adomakoh, Yvonne

Subjects
MULTIPLE myeloma, WEIGHT loss
Abstract

Background: Africans have an increased risk for multiple myeloma (MM) compared to other races. Reports from Africa are few and involve small cohorts, but suggest significant epidemiological and clinical differences from Caucasian patients. Objective: This report describes the clinic-pathological features of MM patients in Ghana at diagnosis, and the factors affecting their survival. Methods: A retrospective review of 169 MM cases diagnosed in a Ghanaian tertiary hospital from 2002-2016. Results: Median age was 58 years, with 29% ≤50 years. One-third presented >12 months after onset of symptoms, which included bone pain (96%), anaemia (67%), weight loss (55%) and fractures (44%). Myeloma-related tissue impairment included hypercalcaemia (36%), renal impairment (33%), severe anaemia (52%) and osteolytic lesions (76%); 51.3% of patients were diagnosed in ISS Stage III. Median survival was 33 months; 1-year and 5-year overall survival were 51.6% and 15.5%, respectively. Neither the age at diagnosis nor the duration of symptoms prior to diagnosis correlated with prognosis. Median survival improved with early ISS stage, haemoglobin >8g/dL, plasmacytosis <20%, and normal creatinine and calcium levels. Conclusion: Early onset and late stage presentation are common at diagnosis of MM patients in Ghana, but do not affect survival. Studies into genetic associations are recommended. [ABSTRACT FROM AUTHOR]

Published
2019
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33. Multidisciplinary care results in similar maternal and perinatal mortality rates for women with and without SCD in a low‐resource setting.

Author

Oppong, Samuel A., Asare, Eugenia V., Olayemi, Edeghonghon, Boafor, Theodore, Dei‐Adomakoh, Yvonne, Swarry‐Deen, Alim, Mensah, Enoch, Osei‐Bonsu, Yvonne, Crabbe, Selina, Musah, Latif, Hayfron‐Benjamin, Charles, Covert, Brittany, Kassim, Adetola A., James, Andra, Rodeghier, Mark, Audet, Carolyn, and DeBaun, Michael R.

Published
2019
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