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1. Degree of food processing and breast cancer risk: a prospective study in 9 European countries

Author: Cairat, Manon, Yammine, Sahar, Fiolet, Thibault, Fournier, Agnès, Boutron-Ruault, Marie-Christine, Laouali, Nasser, Mancini, Francesca Romana, Severi, Gianluca, Berstein, Fernanda Morales, Rauber, Fernanda, Levy, Renata Bertazzi, Skeie, Guri, Borch, Kristin Benjaminsen, Tjønneland, Anne, Mellemkjær, Lene, Borné, Yan, Rosendahl, Ann H., Masala, Giovanna, Giraudo, Maria Teresa, de Magistris, Maria Santucci, Katzke, Verena, Bajracharya, Rashmita, Santiuste, Carmen, Amiano, Pilar, Bodén, Stina, Castro-Espin, Carlota, Sánchez, Maria-Jose, Touvier, Mathilde, Deschasaux-Tanguy, Mélanie, Srour, Bernard, Schulze, Matthias B., Guevara, Marcela, Kliemann, Nathalie, Lopez, Jessica Blanco, Al Nahas, Aline, Chang, Kiara, Vamos, Eszter P., Millett, Christopher, Riboli, Elio, Heath, Alicia K., Biessy, Carine, Viallon, Vivian, Casagrande, Corinne, Nicolas, Genevieve, Gunter, Marc J., and Huybrechts, Inge
Published: 2024
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2. Dietary patterns related to biological mechanisms and survival after breast cancer diagnosis: results from a cohort study

Author: Castro-Espin, Carlota, Bonet, Catalina, Crous-Bou, Marta, Katzke, Verena, Le Cornet, Charlotte, Jannasch, Franziska, Schulze, Matthias B., Olsen, Anja, Tjønneland, Anne, Dahm, Christina C., Antoniussen, Christian S., Sánchez, Maria Jose, Amiano, Pilar, Chirlaque, María Dolores, Guevara, Marcela, Agnoli, Claudia, Tumino, Rosario, Sacerdote, Carlotta, De Magistris, Maria Santucci, Sund, Malin, Bodén, Stina, Jensen, Torill Enget, Olsen, Karina Standahl, Skeie, Guri, Gunter, Marc J., Rinaldi, Sabina, Gonzalez-Gil, Esther M., Weiderpass, Elisabete, Christakoudi, Sofia, Heath, Alicia K., Dossus, Laure, and Agudo, Antonio
Published: 2023
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3. Pre-diagnostic circulating resistin concentrations and mortality among individuals with colorectal cancer: Results from the European Prospective Investigation into Cancer and Nutrition study

Author: Pham, Thu Thi, Nimptsch, Katharina, Aleksandrova, Krasimira, Jenab, Mazda, Fedirko, Veronika, Wu, Kana, Eriksen, Anne Kirstine, Tjønneland, Anne, Severi, Gianluca, Rothwell, Joseph, Kaaks, Rudolf, Katzke, Verena, Catalano, Alberto, Agnoli, Claudia, Masala, Giovanna, De Magistris, Maria Santucci, Tumino, Rosario, Vermeulen, Roel, Aizpurua, Amaia, Trobajo-Sanmartín, Camino, Chirlaque, María-Dolores, Sánchez, Maria-Jose, Lu, Sai San Moon, Cross, Amanda J, Christakoudi, Sofia, Weiderpass, Elisabete, Pischon, Tobias, Pham, Thu Thi, Nimptsch, Katharina, Aleksandrova, Krasimira, Jenab, Mazda, Fedirko, Veronika, Wu, Kana, Eriksen, Anne Kirstine, Tjønneland, Anne, Severi, Gianluca, Rothwell, Joseph, Kaaks, Rudolf, Katzke, Verena, Catalano, Alberto, Agnoli, Claudia, Masala, Giovanna, De Magistris, Maria Santucci, Tumino, Rosario, Vermeulen, Roel, Aizpurua, Amaia, Trobajo-Sanmartín, Camino, Chirlaque, María-Dolores, Sánchez, Maria-Jose, Lu, Sai San Moon, Cross, Amanda J, Christakoudi, Sofia, Weiderpass, Elisabete, and Pischon, Tobias
Abstract: Resistin is a protein involved in inflammation and angiogenesis processes and may play a role in the progression of colorectal cancer (CRC). However, it remains unclear whether resistin is associated with increased mortality after CRC diagnosis. We examined pre-diagnostic serum resistin concentrations in relation to CRC-specific and all-cause mortality among 1343 incident CRC cases from the European Prospective Investigation into Cancer and Nutrition cohort. For CRC-specific mortality as the primary outcome, hazard ratios (HRs) and 95% confidence intervals (95% CI) were estimated from competing risk analyses based on cause-specific Cox proportional hazards models and further in sensitivity analyses using Fine-Gray proportional subdistribution hazards models. For all-cause mortality as the secondary outcome, Cox proportional hazards models were used. Subgroup analyses were performed by sex, tumor subsite, tumor stage, body mass index and time to CRC diagnosis. Resistin was measured on a median of 4.8 years before CRC diagnosis. During a median follow-up of 8.2 years, 474 deaths from CRC and 147 deaths from other causes were observed. Resistin concentrations were not associated with CRC-specific mortality (HR Q4vsQ1 = 0.95, 95% CI: 0.73-1.23; P trend = .97; and HR per doubling of resistin concentration = 1.00; 95% CI: 0.84-1.19; P = .98) or all-cause mortality. Results from competing risk (sensitivity) analysis were similar. No associations were found in any subgroup analyses. These findings suggest no association between pre-diagnostic circulating resistin concentrations and CRC-specific or all-cause mortality among persons with CRC, and the potential insignificance of resistin in CRC progression.
Published: 2024

4. Pre-diagnostic circulating resistin concentrations and mortality among individuals with colorectal cancer: Results from the European Prospective Investigation into Cancer and Nutrition study

Author: IRAS OH Epidemiology Chemical Agents, IRAS – One Health Chemical, Pham, Thu Thi, Nimptsch, Katharina, Aleksandrova, Krasimira, Jenab, Mazda, Fedirko, Veronika, Wu, Kana, Eriksen, Anne Kirstine, Tjønneland, Anne, Severi, Gianluca, Rothwell, Joseph, Kaaks, Rudolf, Katzke, Verena, Catalano, Alberto, Agnoli, Claudia, Masala, Giovanna, De Magistris, Maria Santucci, Tumino, Rosario, Vermeulen, Roel, Aizpurua, Amaia, Trobajo-Sanmartín, Camino, Chirlaque, María-Dolores, Sánchez, Maria-Jose, Lu, Sai San Moon, Cross, Amanda J, Christakoudi, Sofia, Weiderpass, Elisabete, Pischon, Tobias, IRAS OH Epidemiology Chemical Agents, IRAS – One Health Chemical, Pham, Thu Thi, Nimptsch, Katharina, Aleksandrova, Krasimira, Jenab, Mazda, Fedirko, Veronika, Wu, Kana, Eriksen, Anne Kirstine, Tjønneland, Anne, Severi, Gianluca, Rothwell, Joseph, Kaaks, Rudolf, Katzke, Verena, Catalano, Alberto, Agnoli, Claudia, Masala, Giovanna, De Magistris, Maria Santucci, Tumino, Rosario, Vermeulen, Roel, Aizpurua, Amaia, Trobajo-Sanmartín, Camino, Chirlaque, María-Dolores, Sánchez, Maria-Jose, Lu, Sai San Moon, Cross, Amanda J, Christakoudi, Sofia, Weiderpass, Elisabete, and Pischon, Tobias
Published: 2024

5. Dietary amino acids and risk of stroke subtypes : a prospective analysis of 356,000 participants in seven European countries

Author: Tong, Tammy Y. N., Clarke, Robert, Schmidt, Julie A., Huybrechts, Inge, Noor, Urwah, Forouhi, Nita G., Imamura, Fumiaki, Travis, Ruth C., Weiderpass, Elisabete, Aleksandrova, Krasimira, Dahm, Christina C., van der Schouw, Yvonne T., Overvad, Kim, Kyrø, Cecilie, Tjønneland, Anne, Kaaks, Rudolf, Katzke, Verena, Schiborn, Catarina, Schulze, Matthias B., Mayen-Chacon, Ana-Lucia, Masala, Giovanna, Sieri, Sabina, de Magistris, Maria Santucci, Tumino, Rosario, Sacerdote, Carlotta, Boer, Jolanda M. A., Verschuren, W. M. Monique, Brustad, Magritt, Nøst, Therese Haugdahl, Crous-Bou, Marta, Petrova, Dafina, Amiano, Pilar, Huerta, José María, Moreno-Iribas, Conchi, Engström, Gunnar, Melander, Olle, Johansson, Kristina, Lindvall, Kristina, Aglago, Elom K., Heath, Alicia K., Butterworth, Adam S., Danesh, John, Key, Timothy J., Tong, Tammy Y. N., Clarke, Robert, Schmidt, Julie A., Huybrechts, Inge, Noor, Urwah, Forouhi, Nita G., Imamura, Fumiaki, Travis, Ruth C., Weiderpass, Elisabete, Aleksandrova, Krasimira, Dahm, Christina C., van der Schouw, Yvonne T., Overvad, Kim, Kyrø, Cecilie, Tjønneland, Anne, Kaaks, Rudolf, Katzke, Verena, Schiborn, Catarina, Schulze, Matthias B., Mayen-Chacon, Ana-Lucia, Masala, Giovanna, Sieri, Sabina, de Magistris, Maria Santucci, Tumino, Rosario, Sacerdote, Carlotta, Boer, Jolanda M. A., Verschuren, W. M. Monique, Brustad, Magritt, Nøst, Therese Haugdahl, Crous-Bou, Marta, Petrova, Dafina, Amiano, Pilar, Huerta, José María, Moreno-Iribas, Conchi, Engström, Gunnar, Melander, Olle, Johansson, Kristina, Lindvall, Kristina, Aglago, Elom K., Heath, Alicia K., Butterworth, Adam S., Danesh, John, and Key, Timothy J.
Abstract: Purpose: Previously reported associations of protein-rich foods with stroke subtypes have prompted interest in the assessment of individual amino acids. We examined the associations of dietary amino acids with risks of ischaemic and haemorrhagic stroke in the EPIC study. Methods: We analysed data from 356,142 participants from seven European countries. Dietary intakes of 19 individual amino acids were assessed using validated country-specific dietary questionnaires, calibrated using additional 24-h dietary recalls. Multivariable-adjusted Cox regression models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) of ischaemic and haemorrhagic stroke in relation to the intake of each amino acid. The role of blood pressure as a potential mechanism was assessed in 267,642 (75%) participants. Results: After a median follow-up of 12.9 years, 4295 participants had an ischaemic stroke and 1375 participants had a haemorrhagic stroke. After correction for multiple testing, a higher intake of proline (as a percent of total protein) was associated with a 12% lower risk of ischaemic stroke (HR per 1 SD higher intake 0.88; 95% CI 0.82, 0.94). The association persisted after mutual adjustment for all other amino acids, systolic and diastolic blood pressure. The inverse associations of isoleucine, leucine, valine, phenylalanine, threonine, tryptophan, glutamic acid, serine and tyrosine with ischaemic stroke were each attenuated with adjustment for proline intake. For haemorrhagic stroke, no statistically significant associations were observed in the continuous analyses after correcting for multiple testing. Conclusion: Higher proline intake may be associated with a lower risk of ischaemic stroke, independent of other dietary amino acids and blood pressure.
Published: 2024
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6. Dietary amino acids and risk of stroke subtypes: a prospective analysis of 356,000 participants in seven European countries

Author: Cardiovasculaire Epi Team 1, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Cardiometabolic Health, Tong, Tammy Y.N., Clarke, Robert, Schmidt, Julie A., Huybrechts, Inge, Noor, Urwah, Forouhi, Nita G., Imamura, Fumiaki, Travis, Ruth C., Weiderpass, Elisabete, Aleksandrova, Krasimira, Dahm, Christina C., van der Schouw, Yvonne T., Overvad, Kim, Kyrø, Cecilie, Tjønneland, Anne, Kaaks, Rudolf, Katzke, Verena, Schiborn, Catarina, Schulze, Matthias B., Mayen-Chacon, Ana Lucia, Masala, Giovanna, Sieri, Sabina, de Magistris, Maria Santucci, Tumino, Rosario, Sacerdote, Carlotta, Boer, Jolanda M.A., Verschuren, W. M.Monique, Brustad, Magritt, Nøst, Therese Haugdahl, Crous-Bou, Marta, Petrova, Dafina, Amiano, Pilar, Huerta, José María, Moreno-Iribas, Conchi, Engström, Gunnar, Melander, Olle, Johansson, Kristina, Lindvall, Kristina, Aglago, Elom K., Heath, Alicia K., Butterworth, Adam S., Danesh, John, Key, Timothy J., Cardiovasculaire Epi Team 1, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Cardiometabolic Health, Tong, Tammy Y.N., Clarke, Robert, Schmidt, Julie A., Huybrechts, Inge, Noor, Urwah, Forouhi, Nita G., Imamura, Fumiaki, Travis, Ruth C., Weiderpass, Elisabete, Aleksandrova, Krasimira, Dahm, Christina C., van der Schouw, Yvonne T., Overvad, Kim, Kyrø, Cecilie, Tjønneland, Anne, Kaaks, Rudolf, Katzke, Verena, Schiborn, Catarina, Schulze, Matthias B., Mayen-Chacon, Ana Lucia, Masala, Giovanna, Sieri, Sabina, de Magistris, Maria Santucci, Tumino, Rosario, Sacerdote, Carlotta, Boer, Jolanda M.A., Verschuren, W. M.Monique, Brustad, Magritt, Nøst, Therese Haugdahl, Crous-Bou, Marta, Petrova, Dafina, Amiano, Pilar, Huerta, José María, Moreno-Iribas, Conchi, Engström, Gunnar, Melander, Olle, Johansson, Kristina, Lindvall, Kristina, Aglago, Elom K., Heath, Alicia K., Butterworth, Adam S., Danesh, John, and Key, Timothy J.
Published: 2024

7. Pre-diagnostic circulating resistin concentrations and mortality among individuals with colorectal cancer:Results from the European Prospective Investigation into Cancer and Nutrition study

Author: Pham, Thu Thi, Nimptsch, Katharina, Aleksandrova, Krasimira, Jenab, Mazda, Fedirko, Veronika, Wu, Kana, Eriksen, Anne Kirstine, Tjønneland, Anne, Severi, Gianluca, Rothwell, Joseph, Kaaks, Rudolf, Katzke, Verena, Catalano, Alberto, Agnoli, Claudia, Masala, Giovanna, De Magistris, Maria Santucci, Tumino, Rosario, Vermeulen, Roel, Aizpurua, Amaia, Trobajo-Sanmartín, Camino, Chirlaque, María-Dolores, Sánchez, Maria-Jose, Lu, Sai San Moon, Cross, Amanda J, Christakoudi, Sofia, Weiderpass, Elisabete, Pischon, Tobias, Pham, Thu Thi, Nimptsch, Katharina, Aleksandrova, Krasimira, Jenab, Mazda, Fedirko, Veronika, Wu, Kana, Eriksen, Anne Kirstine, Tjønneland, Anne, Severi, Gianluca, Rothwell, Joseph, Kaaks, Rudolf, Katzke, Verena, Catalano, Alberto, Agnoli, Claudia, Masala, Giovanna, De Magistris, Maria Santucci, Tumino, Rosario, Vermeulen, Roel, Aizpurua, Amaia, Trobajo-Sanmartín, Camino, Chirlaque, María-Dolores, Sánchez, Maria-Jose, Lu, Sai San Moon, Cross, Amanda J, Christakoudi, Sofia, Weiderpass, Elisabete, and Pischon, Tobias
Abstract: Resistin is a protein involved in inflammation and angiogenesis processes and may play a role in the progression of colorectal cancer (CRC). However, it remains unclear whether resistin is associated with increased mortality after CRC diagnosis. We examined pre-diagnostic serum resistin concentrations in relation to CRC-specific and all-cause mortality among 1343 incident CRC cases from the European Prospective Investigation into Cancer and Nutrition cohort. For CRC-specific mortality as the primary outcome, hazard ratios (HRs) and 95% confidence intervals (95% CI) were estimated from competing risk analyses based on cause-specific Cox proportional hazards models and further in sensitivity analyses using Fine–Gray proportional subdistribution hazards models. For all-cause mortality as the secondary outcome, Cox proportional hazards models were used. Subgroup analyses were performed by sex, tumor subsite, tumor stage, body mass index and time to CRC diagnosis. Resistin was measured on a median of 4.8 years before CRC diagnosis. During a median follow-up of 8.2 years, 474 deaths from CRC and 147 deaths from other causes were observed. Resistin concentrations were not associated with CRC-specific mortality (HRQ4vsQ1 = 0.95, 95% CI: 0.73–1.23; Ptrend = .97; and HRper doubling of resistin concentration = 1.00; 95% CI: 0.84–1.19; P = .98) or all-cause mortality. Results from competing risk (sensitivity) analysis were similar. No associations were found in any subgroup analyses. These findings suggest no association between pre-diagnostic circulating resistin concentrations and CRC-specific or all-cause mortality among persons with CRC, and the potential insignificance of resistin in CRC progression, Resistin is a protein involved in inflammation and angiogenesis processes and may play a role in the progression of colorectal cancer (CRC). However, it remains unclear whether resistin is associated with increased mortality after CRC diagnosis. We examined pre-diagnostic serum resistin concentrations in relation to CRC-specific and all-cause mortality among 1343 incident CRC cases from the European Prospective Investigation into Cancer and Nutrition cohort. For CRC-specific mortality as the primary outcome, hazard ratios (HRs) and 95% confidence intervals (95% CI) were estimated from competing risk analyses based on cause-specific Cox proportional hazards models and further in sensitivity analyses using Fine-Gray proportional subdistribution hazards models. For all-cause mortality as the secondary outcome, Cox proportional hazards models were used. Subgroup analyses were performed by sex, tumor subsite, tumor stage, body mass index and time to CRC diagnosis. Resistin was measured on a median of 4.8 years before CRC diagnosis. During a median follow-up of 8.2 years, 474 deaths from CRC and 147 deaths from other causes were observed. Resistin concentrations were not associated with CRC-specific mortality (HRQ4vsQ1 = 0.95, 95% CI: 0.73-1.23; Ptrend = .97; and HRper doubling of resistin concentration = 1.00; 95% CI: 0.84-1.19; P = .98) or all-cause mortality. Results from competing risk (sensitivity) analysis were similar. No associations were found in any subgroup analyses. These findings suggest no association between pre-diagnostic circulating resistin concentrations and CRC-specific or all-cause mortality among persons with CRC, and the potential insignificance of resistin in CRC progression.
Published: 2024

8. Main nutrient patterns are associated with prospective weight change in adults from 10 European countries

Author: Freisling, Heinz, Pisa, Pedro T, Ferrari, Pietro, Byrnes, Graham, Moskal, Aurelie, Dahm, Christina C, Vergnaud, Anne-Claire, Boutron-Ruault, Marie-Christine, Fagherazzi, Guy, Cadeau, Claire, Kühn, Tilman, Neamat-Allah, Jasmine, Buijsse, Brian, Boeing, Heiner, Halkjær, Jytte, Tjonneland, Anne, Hansen, Camilla P, Quirós, J Ramón, Travier, Noémie, Molina-Montes, Esther, Amiano, Pilar, Huerta, José M, Barricarte, Aurelio, Khaw, Kay-Tee, Wareham, Nicholas, Key, Tim J, Romaguera, Dora, Lu, Yunxia, Lassale, Camille M, Naska, Androniki, Orfanos, Philippos, Trichopoulou, Antonia, Masala, Giovanna, Pala, Valeria, Berrino, Franco, Tumino, Rosario, Ricceri, Fulvio, de Magistris, Maria Santucci, Bueno-de-Mesquita, H Bas, Ocké, Marga C, Sonestedt, Emily, Ericson, Ulrika, Johansson, Mattias, Skeie, Guri, Weiderpass, Elisabete, Braaten, Tonje, Peeters, Petra HM, and Slimani, Nadia
Subjects: Public Health, Biomedical and Clinical Sciences, Nutrition and Dietetics, Health Sciences, Clinical Research, Prevention, Nutrition, Metabolic and endocrine, Adult, Aged, Ascorbic Acid, Calcium, Dietary, Diet, Dietary Fiber, Dietary Proteins, Europe, Female, Folic Acid, Follow-Up Studies, Humans, Linear Models, Male, Middle Aged, Nutrition Assessment, Phosphorus, Dietary, Prospective Studies, Riboflavin, Surveys and Questionnaires, Weight Gain, beta Carotene, Dietary patterns, Energy balance, Nutrients, Obesity, Public health, Weight gain, Nutrition & Dietetics, Nutrition and dietetics, Epidemiology
Abstract: PurposeVarious food patterns have been associated with weight change in adults, but it is unknown which combinations of nutrients may account for such observations. We investigated associations between main nutrient patterns and prospective weight change in adults.MethodsThis study includes 235,880 participants, 25-70 years old, recruited between 1992 and 2000 in 10 European countries. Intakes of 23 nutrients were estimated from country-specific validated dietary questionnaires using the harmonized EPIC Nutrient DataBase. Four nutrient patterns, explaining 67 % of the total variance of nutrient intakes, were previously identified from principal component analysis. Body weight was measured at recruitment and self-reported 5 years later. The relationship between nutrient patterns and annual weight change was examined separately for men and women using linear mixed models with random effect according to center controlling for confounders.ResultsMean weight gain was 460 g/year (SD 950) and 420 g/year (SD 940) for men and women, respectively. The annual differences in weight gain per one SD increase in the pattern scores were as follows: principal component (PC) 1, characterized by nutrients from plant food sources, was inversely associated with weight gain in men (-22 g/year; 95 % CI -33 to -10) and women (-18 g/year; 95 % CI -26 to -11). In contrast, PC4, characterized by protein, vitamin B2, phosphorus, and calcium, was associated with a weight gain of +41 g/year (95 % CI +2 to +80) and +88 g/year (95 % CI +36 to +140) in men and women, respectively. Associations with PC2, a pattern driven by many micro-nutrients, and with PC3, a pattern driven by vitamin D, were less consistent and/or non-significant.ConclusionsWe identified two main nutrient patterns that are associated with moderate but significant long-term differences in weight gain in adults.
Published: 2016

9. Dietary polyphenol intake in Europe: the European Prospective Investigation into Cancer and Nutrition (EPIC) study

Author: Zamora-Ros, Raul, Knaze, Viktoria, Rothwell, Joseph A, Hémon, Bertrand, Moskal, Aurelie, Overvad, Kim, Tjønneland, Anne, Kyrø, Cecilie, Fagherazzi, Guy, Boutron-Ruault, Marie-Christine, Touillaud, Marina, Katzke, Verena, Kühn, Tilman, Boeing, Heiner, Förster, Jana, Trichopoulou, Antonia, Valanou, Elissavet, Peppa, Eleni, Palli, Domenico, Agnoli, Claudia, Ricceri, Fulvio, Tumino, Rosario, de Magistris, Maria Santucci, Peeters, Petra HM, Bueno-de-Mesquita, H Bas, Engeset, Dagrun, Skeie, Guri, Hjartåker, Anette, Menéndez, Virginia, Agudo, Antonio, Molina-Montes, Esther, Huerta, José María, Barricarte, Aurelio, Amiano, Pilar, Sonestedt, Emily, Nilsson, Lena Maria, Landberg, Rikard, Key, Timothy J, Khaw, Kay-Thee, Wareham, Nicholas J, Lu, Yunxia, Slimani, Nadia, Romieu, Isabelle, Riboli, Elio, and Scalbert, Augustin
Subjects: Public Health, Biomedical and Clinical Sciences, Nutrition and Dietetics, Health Sciences, Complementary and Integrative Health, Nutrition, 6.1 Pharmaceuticals, Evaluation of treatments and therapeutic interventions, Cancer, Adult, Aged, Body Mass Index, Coffee, Cross-Sectional Studies, Diet, Europe, Exercise, Female, Flavonoids, Food Analysis, Food Handling, Fruit, Humans, Hydroxybenzoates, Life Style, Male, Mental Recall, Middle Aged, Nutrition Assessment, Polyphenols, Proanthocyanidins, Prospective Studies, Socioeconomic Factors, Tea, Dietary intake, EPIC, Food sources, Nutrition & Dietetics, Nutrition and dietetics, Epidemiology
Abstract: Background/objectivesPolyphenols are plant secondary metabolites with a large variability in their chemical structure and dietary occurrence that have been associated with some protective effects against several chronic diseases. To date, limited data exist on intake of polyphenols in populations. The current cross-sectional analysis aimed at estimating dietary intakes of all currently known individual polyphenols and total intake per class and subclass, and to identify their main food sources in the European Prospective Investigation into Cancer and Nutrition cohort.MethodsDietary data at baseline were collected using a standardized 24-h dietary recall software administered to 36,037 adult subjects. Dietary data were linked with Phenol-Explorer, a database with data on 502 individual polyphenols in 452 foods and data on polyphenol losses due to cooking and food processing.ResultsMean total polyphenol intake was the highest in Aarhus-Denmark (1786 mg/day in men and 1626 mg/day in women) and the lowest in Greece (744 mg/day in men and 584 mg/day in women). When dividing the subjects into three regions, the highest intake of total polyphenols was observed in the UK health-conscious group, followed by non-Mediterranean (non-MED) and MED countries. The main polyphenol contributors were phenolic acids (52.5-56.9 %), except in men from MED countries and in the UK health-conscious group where they were flavonoids (49.1-61.7 %). Coffee, tea, and fruits were the most important food sources of total polyphenols. A total of 437 different individual polyphenols were consumed, including 94 consumed at a level >1 mg/day. The most abundant ones were the caffeoylquinic acids and the proanthocyanidin oligomers and polymers.ConclusionThis study describes the large number of dietary individual polyphenols consumed and the high variability of their intakes between European populations, particularly between MED and non-MED countries.
Published: 2016

10. Changes in lifestyle and risk of colorectal cancer in the european prospective investigation into cancer and nutrition

Author: Botteri, Edoardo, Peveri, Giulia, Berstad, Paula, Bagnardi, Vincenzo, Chen, Sairah L.F., Sandanger, Torkjel M., Hoff, Geir, Dahm, Christina C., Antoniussen, Christian S., Tjønneland, Anne, Eriksen, Anne Kirstine, Skeie, Guri, Perez-Cornago, Aurora, Huerta, José María, Jakszyn, Paula, Harlid, Sophia, Sundström, Björn, Barricarte, Aurelio, Monninkhof, Evelyn M., Derksen, Jeroen W.G., Schulze, Matthias B., Bueno-De-Mesquita, Bas, Sánchez, Maria-Jose, Cross, Amanda J., Tsilidis, Konstantinos K., De Magistris, Maria Santucci, Kaaks, Rudolf, Katzke, Verena, Rothwell, Joseph A., Laouali, Nasser, Severi, Gianluca, Amiano, Pilar, Contiero, Paolo, Sacerdote, Carlotta, Goldberg, Marcel, Touvier, Mathilde, Freisling, Heinz, Viallon, Vivian, Weiderpass, Elisabete, Riboli, Elio, Gunter, Marc J., Jenab, Mazda, Ferrari, Pietro, Botteri, Edoardo, Peveri, Giulia, Berstad, Paula, Bagnardi, Vincenzo, Chen, Sairah L.F., Sandanger, Torkjel M., Hoff, Geir, Dahm, Christina C., Antoniussen, Christian S., Tjønneland, Anne, Eriksen, Anne Kirstine, Skeie, Guri, Perez-Cornago, Aurora, Huerta, José María, Jakszyn, Paula, Harlid, Sophia, Sundström, Björn, Barricarte, Aurelio, Monninkhof, Evelyn M., Derksen, Jeroen W.G., Schulze, Matthias B., Bueno-De-Mesquita, Bas, Sánchez, Maria-Jose, Cross, Amanda J., Tsilidis, Konstantinos K., De Magistris, Maria Santucci, Kaaks, Rudolf, Katzke, Verena, Rothwell, Joseph A., Laouali, Nasser, Severi, Gianluca, Amiano, Pilar, Contiero, Paolo, Sacerdote, Carlotta, Goldberg, Marcel, Touvier, Mathilde, Freisling, Heinz, Viallon, Vivian, Weiderpass, Elisabete, Riboli, Elio, Gunter, Marc J., Jenab, Mazda, and Ferrari, Pietro
Abstract: Introduction: We investigated the impact of changes in lifestyle habits on colorectal cancer (CRC) risk in a multicountry European cohort. Methods: We used baseline and follow-up questionnaire data from the European Prospective Investigation into Cancer cohort to assess changes in lifestyle habits and their associations with CRC development. We calculated a healthy lifestyle index (HLI) score based on smoking status, alcohol consumption, body mass index, and physical activity collected at the 2 time points. HLI ranged from 0 (most unfavorable) to 16 (most favorable). We estimated the association between HLI changes and CRC risk using Cox regression models and reported hazard ratios (HR) with 95% confidence intervals (CI). Results: Among 295,865 participants, 2,799 CRC cases were observed over a median of 7.8 years. The median time between questionnaires was 5.7 years. Each unit increase in HLI from the baseline to the follow-up assessment was associated with a statistically significant 3% lower CRC risk. Among participants in the top tertile at baseline (HLI > 11), those in the bottom tertile at follow-up (HLI ≤ 9) had a higher CRC risk (HR 1.34; 95% CI 1.02-1.75) than those remaining in the top tertile. Among individuals in the bottom tertile at baseline, those in the top tertile at follow-up had a lower risk (HR 0.77; 95% CI 0.59-1.00) than those remaining in the bottom tertile. Discussion: Improving adherence to a healthy lifestyle was inversely associated with CRC risk, while worsening adherence was positively associated with CRC risk. These results justify and support recommendations for healthy lifestyle changes and healthy lifestyle maintenance for CRC prevention.
Published: 2023
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11. Prediagnostic serum glyceraldehyde-derived advanced glycation end products and mortality among colorectal cancer patients

Author: Mao, Ziling, Baker, Jacqueline Roshelli, Takeuchi, Masayoshi, Hyogo, Hideyuki, Tjønneland, Anne, Eriksen, Anne Kirstine, Severi, Gianluca, Rothwell, Joseph, Laouali, Nasser, Katzke, Verena, Kaaks, Rudolf, Schulze, Matthias B., Palli, Domenico, Sieri, Sabina, de Magistris, Maria Santucci, Tumino, Rosario, Sacerdote, Carlotta, Derksen, Jeroen W. G., Gram, Inger T., Skeie, Guri, Sandanger, Torkjel M., Quirós, Jose Ramón, Crous-Bou, Marta, Sánchez, Maria-Jose, Amiano, Pilar, Colorado-Yohar, Sandra M., Guevara, Marcela, Harlid, Sophia, Johansson, Ingegerd, Perez-Cornago, Aurora, Freisling, Heinz, Gunter, Marc, Weiderpass, Elisabete, Heath, Alicia K., Aglago, Elom, Jenab, Mazda, Fedirko, Veronika, Mao, Ziling, Baker, Jacqueline Roshelli, Takeuchi, Masayoshi, Hyogo, Hideyuki, Tjønneland, Anne, Eriksen, Anne Kirstine, Severi, Gianluca, Rothwell, Joseph, Laouali, Nasser, Katzke, Verena, Kaaks, Rudolf, Schulze, Matthias B., Palli, Domenico, Sieri, Sabina, de Magistris, Maria Santucci, Tumino, Rosario, Sacerdote, Carlotta, Derksen, Jeroen W. G., Gram, Inger T., Skeie, Guri, Sandanger, Torkjel M., Quirós, Jose Ramón, Crous-Bou, Marta, Sánchez, Maria-Jose, Amiano, Pilar, Colorado-Yohar, Sandra M., Guevara, Marcela, Harlid, Sophia, Johansson, Ingegerd, Perez-Cornago, Aurora, Freisling, Heinz, Gunter, Marc, Weiderpass, Elisabete, Heath, Alicia K., Aglago, Elom, Jenab, Mazda, and Fedirko, Veronika
Abstract: Glyceraldehyde-derived advanced glycation end products (glycer-AGEs) could contribute to colorectal cancer development and progression due to their pro-oxidative and pro-inflammatory properties. However, the association of glycer-AGEs with mortality after colorectal cancer diagnosis has not been previously investigated. Circulating glycer-AGEs were measured by competitive ELISA. Multivariable Cox proportional hazards models were used to calculate hazard ratios (HRs) and corresponding 95% confidence intervals (CIs) for associations of circulating glycer-AGEs concentrations with CRC-specific and all-cause mortality among 1034 colorectal cancer (CRC) cases identified within the European Prospective Investigation into Cancer and Nutrition (EPIC) study between 1993 and 2013. During a mean of 48 months of follow-up, 529 participants died (409 from CRC). Glycer-AGEs were statistically significantly positively associated with CRC-specific (HRQ5 vs Q1 = 1.53, 95% CI: 1.04-2.25, Ptrend =.002) and all-cause (HRQ5 vs Q1 = 1.62, 95% CI: 1.16-2.26, Ptrend <.001) mortality among individuals with CRC. There was suggestion of a stronger association between glycer-AGEs and CRC-specific mortality among patients with distal colon cancer (per SD increment: HRproximal colon = 1.02, 95% CI: 0.74-1.42; HRdistal colon = 1.51, 95% CI: 1.20-1.91; Peffect modification =.02). The highest HR was observed among CRC cases in the highest body mass index (BMI) and glycer-AGEs category relative to lowest BMI and glycer-AGEs category for both CRC-specific (HR = 1.78, 95% CI: 1.02-3.01) and all-cause mortality (HR = 2.15, 95% CI: 1.33-3.47), although no statistically significant effect modification was observed. Our study found that prediagnostic circulating glycer-AGEs are positively associated with CRC-specific and all-cause mortality among individuals with CRC. Further investigations in other populations and stratifying by tumor location and BMI are warranted.
Published: 2023
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12. Dietary patterns related to biological mechanisms and survival after breast cancer diagnosis:results from a cohort study

Author: Castro-Espin, Carlota, Bonet, Catalina, Crous-Bou, Marta, Katzke, Verena, Le Cornet, Charlotte, Jannasch, Franziska, Schulze, Matthias B., Olsen, Anja, Tjønneland, Anne, Dahm, Christina C., Antoniussen, Christian S., Sánchez, Maria Jose, Amiano, Pilar, Chirlaque, María Dolores, Guevara, Marcela, Agnoli, Claudia, Tumino, Rosario, Sacerdote, Carlotta, De Magistris, Maria Santucci, Sund, Malin, Bodén, Stina, Jensen, Torill Enget, Olsen, Karina Standahl, Skeie, Guri, Gunter, Marc J., Rinaldi, Sabina, Gonzalez-Gil, Esther M., Weiderpass, Elisabete, Christakoudi, Sofia, Heath, Alicia K., Dossus, Laure, Agudo, Antonio, Castro-Espin, Carlota, Bonet, Catalina, Crous-Bou, Marta, Katzke, Verena, Le Cornet, Charlotte, Jannasch, Franziska, Schulze, Matthias B., Olsen, Anja, Tjønneland, Anne, Dahm, Christina C., Antoniussen, Christian S., Sánchez, Maria Jose, Amiano, Pilar, Chirlaque, María Dolores, Guevara, Marcela, Agnoli, Claudia, Tumino, Rosario, Sacerdote, Carlotta, De Magistris, Maria Santucci, Sund, Malin, Bodén, Stina, Jensen, Torill Enget, Olsen, Karina Standahl, Skeie, Guri, Gunter, Marc J., Rinaldi, Sabina, Gonzalez-Gil, Esther M., Weiderpass, Elisabete, Christakoudi, Sofia, Heath, Alicia K., Dossus, Laure, and Agudo, Antonio
Abstract: Background Inflammatory, insulin and oestrogenic pathways have been linked to breast cancer (BC). We aimed to examine the relationship between pre-diagnostic dietary patterns related to these mechanisms and BC survival. Methods The diabetes risk reduction diet (DRRD), inflammatory score of diet (ISD) and oestrogen-related dietary pattern (ERDP) were calculated using dietary data from the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Cox proportional hazards models were used to assess associations between dietary patterns and overall mortality and competing risk models for associations with BC-specific mortality. Results We included 13,270 BC cases with a mean follow-up after diagnosis of 8.6 years, representing 2340 total deaths, including 1475 BC deaths. Higher adherence to the DRRD score was associated with lower overall mortality (HR1–SD 0.92; 95%CI 0.87–0.96). Greater adherence to pro-inflammatory diets was borderline associated with 6% higher mortality HR1–SD 1.06; 95%CI 1.00–1.12. No significant association with the oestrogen-related dietary pattern was observed. None of the dietary patterns were associated with BC-specific mortality. Conclusions Greater adherence to an anti-diabetic and anti-inflammatory diet prior to diagnosis is associated with lower overall mortality among BC survivors. Long-term adherence to these dietary patterns could be a means to improve the prognosis of BC survivors., Background: Inflammatory, insulin and oestrogenic pathways have been linked to breast cancer (BC). We aimed to examine the relationship between pre-diagnostic dietary patterns related to these mechanisms and BC survival. Methods: The diabetes risk reduction diet (DRRD), inflammatory score of diet (ISD) and oestrogen-related dietary pattern (ERDP) were calculated using dietary data from the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Cox proportional hazards models were used to assess associations between dietary patterns and overall mortality and competing risk models for associations with BC-specific mortality. Results: We included 13,270 BC cases with a mean follow-up after diagnosis of 8.6 years, representing 2340 total deaths, including 1475 BC deaths. Higher adherence to the DRRD score was associated with lower overall mortality (HR1–SD 0.92; 95%CI 0.87–0.96). Greater adherence to pro-inflammatory diets was borderline associated with 6% higher mortality HR1–SD 1.06; 95%CI 1.00–1.12. No significant association with the oestrogen-related dietary pattern was observed. None of the dietary patterns were associated with BC-specific mortality. Conclusions: Greater adherence to an anti-diabetic and anti-inflammatory diet prior to diagnosis is associated with lower overall mortality among BC survivors. Long-term adherence to these dietary patterns could be a means to improve the prognosis of BC survivors.
Published: 2023

13. Associations between dietary inflammatory scores and biomarkers of inflammation in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort

Author: Cardiometabolic Health, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Lécuyer, Lucie, Laouali, Nasser, Viallon, Vivian, Artaud, Fanny, Hébert, James R, Shivappa, Nitin, Agudo, Antonio, Tjønneland, Anne, Mellemkjær, Lene, Kaaks, Rudolf, Katzke, Verena A, Schulze, Matthias B, Frenoy, Pauline, Mancini, Francesca Romana, De Magistris, Maria Santucci, Macciotta, Alessandra, Masala, Giovanna, Agnoli, Claudia, Tumino, Rosario, Boer, Jolanda M A, Verschuren, W M Monique, Enget Jensen, Torill M, Olsen, Karina Standahl, Skeie, Guri, Chirlaque, María-Dolores, Petrova, Dafina, Castro-Espin, Carlota, Quirós, J Ramón, Guevara, Marcela, Amiano, Pilar, Borné, Yan, Sandström, Maria, Nilsson, Lena Maria, Heath, Alicia K, Mayen, Ana-Lucia, Huybrechts, Inge, Weiderpass, Elisabete, Boutron-Ruault, Marie-Christine, Dossus, Laure, Rinaldi, Sabina, Truong, Thérèse, Cardiometabolic Health, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Lécuyer, Lucie, Laouali, Nasser, Viallon, Vivian, Artaud, Fanny, Hébert, James R, Shivappa, Nitin, Agudo, Antonio, Tjønneland, Anne, Mellemkjær, Lene, Kaaks, Rudolf, Katzke, Verena A, Schulze, Matthias B, Frenoy, Pauline, Mancini, Francesca Romana, De Magistris, Maria Santucci, Macciotta, Alessandra, Masala, Giovanna, Agnoli, Claudia, Tumino, Rosario, Boer, Jolanda M A, Verschuren, W M Monique, Enget Jensen, Torill M, Olsen, Karina Standahl, Skeie, Guri, Chirlaque, María-Dolores, Petrova, Dafina, Castro-Espin, Carlota, Quirós, J Ramón, Guevara, Marcela, Amiano, Pilar, Borné, Yan, Sandström, Maria, Nilsson, Lena Maria, Heath, Alicia K, Mayen, Ana-Lucia, Huybrechts, Inge, Weiderpass, Elisabete, Boutron-Ruault, Marie-Christine, Dossus, Laure, Rinaldi, Sabina, and Truong, Thérèse
Published: 2023

14. Changes in Lifestyle and Risk of Colorectal Cancer in the European Prospective Investigation Into Cancer and Nutrition

Author: Epi Kanker Team C, Cancer, JC onderzoeksprogramma Kanker, Epi Kanker Team B, Botteri, Edoardo, Peveri, Giulia, Berstad, Paula, Bagnardi, Vincenzo, Chen, Sairah L.F., Sandanger, Torkjel M., Hoff, Geir, Dahm, Christina C., Antoniussen, Christian S., Tjønneland, Anne, Eriksen, Anne Kirstine, Skeie, Guri, Perez-Cornago, Aurora, Huerta, José María, Jakszyn, Paula, Harlid, Sophia, Sundström, Björn, Barricarte, Aurelio, Monninkhof, Evelyn M., Derksen, Jeroen W.G., Schulze, Matthias B., Bueno-De-Mesquita, Bas, Sánchez, Maria Jose, Cross, Amanda J., Tsilidis, Konstantinos K., De Magistris, Maria Santucci, Kaaks, Rudolf, Katzke, Verena, Rothwell, Joseph A., Laouali, Nasser, Severi, Gianluca, Amiano, Pilar, Contiero, Paolo, Sacerdote, Carlotta, Goldberg, Marcel, Touvier, Mathilde, Freisling, Heinz, Viallon, Vivian, Weiderpass, Elisabete, Riboli, Elio, Gunter, Marc J., Jenab, Mazda, Ferrari, Pietro, Epi Kanker Team C, Cancer, JC onderzoeksprogramma Kanker, Epi Kanker Team B, Botteri, Edoardo, Peveri, Giulia, Berstad, Paula, Bagnardi, Vincenzo, Chen, Sairah L.F., Sandanger, Torkjel M., Hoff, Geir, Dahm, Christina C., Antoniussen, Christian S., Tjønneland, Anne, Eriksen, Anne Kirstine, Skeie, Guri, Perez-Cornago, Aurora, Huerta, José María, Jakszyn, Paula, Harlid, Sophia, Sundström, Björn, Barricarte, Aurelio, Monninkhof, Evelyn M., Derksen, Jeroen W.G., Schulze, Matthias B., Bueno-De-Mesquita, Bas, Sánchez, Maria Jose, Cross, Amanda J., Tsilidis, Konstantinos K., De Magistris, Maria Santucci, Kaaks, Rudolf, Katzke, Verena, Rothwell, Joseph A., Laouali, Nasser, Severi, Gianluca, Amiano, Pilar, Contiero, Paolo, Sacerdote, Carlotta, Goldberg, Marcel, Touvier, Mathilde, Freisling, Heinz, Viallon, Vivian, Weiderpass, Elisabete, Riboli, Elio, Gunter, Marc J., Jenab, Mazda, and Ferrari, Pietro
Published: 2023

15. Dietary Intakes of Animal and Plant Proteins and Risk of Colorectal Cancer: The EPIC-Italy Cohort

Author: Sieri, Sabina, primary, Agnoli, Claudia, additional, Pala, Valeria, additional, Grioni, Sara, additional, Palli, Domenico, additional, Bendinelli, Benedetta, additional, Macciotta, Alessandra, additional, Ricceri, Fulvio, additional, Panico, Salvatore, additional, De Magistris, Maria Santucci, additional, Tumino, Rosario, additional, Fontana, Luigi, additional, and Krogh, Vittorio, additional
Published: 2022
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16. Inflammatory potential of diet and pancreatic cancer risk in the EPIC study

Author: Epi Kanker Team B, Cancer, Cayssials, Valerie, Buckland, Genevieve, Crous-Bou, Marta, Bonet, Catalina, Weiderpass, Elisabete, Skie, Guri, Aune, Dagfinn, Heath, Alicia, Nøst, Therese Haugdahl, Masala, Giovanna, Agnoli, Claudia, De Magistris, Maria Santucci, Bueno-de-Mesquita, Bas, Derksen, Jeroen, Huybrechts, Inge, Ferrari, Pietro, Franklin, Oscar, Bodén, Stina, Schulze, Matthias, Huerta, Jose Maria, Barricarte, Aurelio, Sacerdote, Carlotta, Amiano, Pilar, Tumino, Rosario, Molina-Montes, Esther, Tjønneland, Anne, Kyrø, Cecilie, Severi, Gianluca, Boutron-Ruault, Marie Christine, Rebours, Vinciane, Katzke, Verena, Agudo, Antonio, Jakszyn, Paula, Epi Kanker Team B, Cancer, Cayssials, Valerie, Buckland, Genevieve, Crous-Bou, Marta, Bonet, Catalina, Weiderpass, Elisabete, Skie, Guri, Aune, Dagfinn, Heath, Alicia, Nøst, Therese Haugdahl, Masala, Giovanna, Agnoli, Claudia, De Magistris, Maria Santucci, Bueno-de-Mesquita, Bas, Derksen, Jeroen, Huybrechts, Inge, Ferrari, Pietro, Franklin, Oscar, Bodén, Stina, Schulze, Matthias, Huerta, Jose Maria, Barricarte, Aurelio, Sacerdote, Carlotta, Amiano, Pilar, Tumino, Rosario, Molina-Montes, Esther, Tjønneland, Anne, Kyrø, Cecilie, Severi, Gianluca, Boutron-Ruault, Marie Christine, Rebours, Vinciane, Katzke, Verena, Agudo, Antonio, and Jakszyn, Paula
Published: 2022

17. Inflammatory potential of diet and pancreatic cancer risk in the EPIC study

Author: Cayssials, Valerie, Buckland, Genevieve, Crous-Bou, Marta, Bonet, Catalina, Weiderpass, Elisabete, Skie, Guri, Aune, Dagfinn, Heath, Alicia, Nøst, Therese Haugdahl, Masala, Giovanna, Agnoli, Claudia, De Magistris, Maria Santucci, Bueno-de-Mesquita, Bas, Derksen, Jeroen, Huybrechts, Inge, Ferrari, Pietro, Franklin, Oskar, Bodén, Stina, Schulze, Matthias, Huerta, Jose Maria, Barricarte, Aurelio, Sacerdote, Carlotta, Amiano, Pilar, Tumino, Rosario, Molina-Montes, Esther, Tjønneland, Anne, Kyrø, Cecilie, Severi, Gianluca, Boutron-Ruault, Marie-Christine, Rebours, Vinciane, Katzke, Verena, Agudo, Antonio, Jakszyn, Paula, Cayssials, Valerie, Buckland, Genevieve, Crous-Bou, Marta, Bonet, Catalina, Weiderpass, Elisabete, Skie, Guri, Aune, Dagfinn, Heath, Alicia, Nøst, Therese Haugdahl, Masala, Giovanna, Agnoli, Claudia, De Magistris, Maria Santucci, Bueno-de-Mesquita, Bas, Derksen, Jeroen, Huybrechts, Inge, Ferrari, Pietro, Franklin, Oskar, Bodén, Stina, Schulze, Matthias, Huerta, Jose Maria, Barricarte, Aurelio, Sacerdote, Carlotta, Amiano, Pilar, Tumino, Rosario, Molina-Montes, Esther, Tjønneland, Anne, Kyrø, Cecilie, Severi, Gianluca, Boutron-Ruault, Marie-Christine, Rebours, Vinciane, Katzke, Verena, Agudo, Antonio, and Jakszyn, Paula
Abstract: Purpose: There is existing evidence on the potential role of chronic inflammation in the pathogenesis of pancreatic cancer (PC) and on how risk may be modulated by dietary factors. Pro-inflammatory diets are suggested to be associated with increased risk of PC but, so far, evidence remains not conclusive. We examined the association between the dietary inflammatory potential and PC risk within the European Prospective Investigation into Cancer and Nutrition (EPIC) study, which includes 450,112 participants. Methods: After a 14-year follow-up, a total of 1239 incident PC cases were included in this study. The inflammatory potential of the diet was estimated using an Inflammatory Score of the Diet (ISD). Hazard ratios (HRs) and 95% confidence intervals (CIs) for the association between the ISD and PC were estimated using multivariable Cox regression models, adjusted for known risk factors for PC. Results: Participants with higher ISDs had a higher risk of developing PCs. In the fully adjusted multivariate model, the risk of PC increased by 11% (HR 1.11, 95% CI 1.02–1.22) for 1 point each standard deviation increase in the ISD score. Neither obesity nor any other known risk factor for PC showed statistically significant interactions. Conclusion: To the best of our knowledge, this is the first prospective study reporting a positive relationship between the inflammatory potential of diet and PC. Since early diagnosis and treatment of pancreatic cancer might be challenging, prevention remains the major hope for reducing the burden of this disease.
Published: 2022
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18. Factors associated with serum ferritin levels and iron excess: results from the EPIC-EurGast study

Author: Universitat Rovira i Virgili, Iglesias-Vazquez, Lucia; Arija, Victoria; Aranda, Nuria; Aglago, Elom K.; Cross, Amanda J.; Schulze, Matthias B.; Quintana Pacheco, Daniel; Kuhn, Tilman; Weiderpass, Elisabete; Tumino, Rosario; Redondo-Sanchez, Daniel; de Magistris, Maria Santucci; Palli, Domenico; Ardanaz, Eva; Laouali, Nasser; Sonestedt, Emily; Drake, Isabel; Rizzolo, Lucia; Santiuste, Carmen; Sacerdote, Carlotta; Quiros, Ramon; Amiano, Pilar; Agudo, Antonio; Jakszyn, Paula, Universitat Rovira i Virgili, and Iglesias-Vazquez, Lucia; Arija, Victoria; Aranda, Nuria; Aglago, Elom K.; Cross, Amanda J.; Schulze, Matthias B.; Quintana Pacheco, Daniel; Kuhn, Tilman; Weiderpass, Elisabete; Tumino, Rosario; Redondo-Sanchez, Daniel; de Magistris, Maria Santucci; Palli, Domenico; Ardanaz, Eva; Laouali, Nasser; Sonestedt, Emily; Drake, Isabel; Rizzolo, Lucia; Santiuste, Carmen; Sacerdote, Carlotta; Quiros, Ramon; Amiano, Pilar; Agudo, Antonio; Jakszyn, Paula
Abstract: Purpose Excess iron is involved in the development of non-communicable diseases such as cancer, type 2 diabetes and cardiovascular conditions. We aimed to describe the prevalence of excess iron and its determinants in healthy European adults. Methods Sociodemographic, lifestyle, iron status, dietary information, and HFE genotyping were obtained from controls from the nested case-control study EPIC-EurGast study. High sensitivity C-reactive protein (hsCRP) was measured to address possible systemic inflammation. Descriptive and multivariate analyses were used to assess iron status and its determinants. Results Out of the 828 participants (median age: 58.7 years), 43% were females. Median serum ferritin and prevalence of excess iron were 143.7 mu g/L and 35.2% in males, respectively, and 77 mu g/L and 20% in females, both increasing with latitude across Europe. Prevalence of HFE C282Y mutation was significantly higher in Northern and Central Europe (similar to 11%) than in the South (5%). Overweight/obesity, age, and daily alcohol and heme iron intake were independent determinants for iron status, with sex differences even after excluding participants with hsCRP > 5 mg/L. Obese males showed a greater consumption of alcohol, total and red meat, and heme iron, compared with those normal weight. Conclusion Obesity, higher alcohol and heme iron consumption were the main risk factors for excess iron in males while only age was associated with iron overload in females. Weight control and promoting healthy lifestyle may help prevent iron overload, especially in obese people. Further research is needed to clarify determinants of excess iron in the healthy adult population, helping to reduce the associated comorbidities.
Published: 2022

19. Dietary intake of animal and plant proteins and risk of all cause and cause-specific mortality: The Epic-Italy cohort

Author: Fontana, Luigi, primary, Sieri, Sabina, additional, Ricceri, Fulvio, additional, Agnoli, Claudia, additional, Pala, Valeria, additional, Masala, Giovanna, additional, Saieva, Calogero, additional, Catalano, Alberto, additional, Macciotta, Alessandra, additional, Tumino, Rosario, additional, Panico, Salvatore, additional, De Magistris, Maria Santucci, additional, and Krogh, Vittorio, additional
Published: 2022
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20. Urinary Concentrations of (+)-Catechin and (-)-Epicatechin as Biomarkers of Dietary Intake of Flavan-3-ols in the European Prospective Investigation into Cancer and Nutrition (EPIC) Study

Author: Almanza-Aguilera, Enrique, primary, Ceballos-Sánchez, Daniela, additional, Achaintre, David, additional, Rothwell, Joseph A, additional, Laouali, Nasser, additional, Severi, Gianluca, additional, Katzke, Verena, additional, Johnson, Theron, additional, Schulze, Matthias B, additional, Palli, Domenico, additional, Gargano, Giuliana, additional, de Magistris, Maria Santucci, additional, Tumino, Rosario, additional, Sacerdote, Carlotta, additional, Scalbert, Augustin, additional, and Zamora-Ros, Raul, additional
Published: 2021
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21. A comparison of complementary measures of vitamin B6 status, function, and metabolism in the European Prospective Investigation into Cancer and Nutrition (EPIC) study

Author: Clasen, Joanna L, primary, Heath, Alicia K, additional, Van Puyvelde, Heleen, additional, Huybrechts, Inge, additional, Park, Jin Young, additional, Ferrari, Pietro, additional, Johansson, Mattias, additional, Scelo, Ghislaine, additional, Ulvik, Arve, additional, Midttun, Øivind, additional, Ueland, Per Magne, additional, Dahm, Christina C, additional, Halkjær, Jytte, additional, Olsen, Anja, additional, Johnson, Theron, additional, Katzke, Verena, additional, Schulze, Matthias B, additional, Masala, Giovanna, additional, Segrado, Francesco, additional, de Magistris, Maria Santucci, additional, Sacerdote, Carlotta, additional, Ocké, Marga C, additional, Luján-Barroso, Leila, additional, Ching-López, Ana, additional, Huerta, José María, additional, Ardanaz, Eva, additional, Amiano, Pilar, additional, Ericson, Ulrika, additional, Manjer, Jonas, additional, Gylling, Björn, additional, Johansson, Ingegerd, additional, Schmidt, Julie, additional, Weiderpass, Elisabete, additional, Riboli, Elio, additional, Cross, Amanda J, additional, and Muller, David C, additional
Published: 2021
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22. Polyphenol intake and epithelial ovarian cancer risk in the European prospective investigation into cancer and nutrition (Epic) study

Author: Londoño, Catalina, Cayssials, Valerie, de Villasante, Izar, Crous-Bou, Marta, Scalbert, Augustin, Weiderpass, Elisabete, Agudo, Antonio, Tjønneland, Anne, Olsen, Anja, Overvad, Kim, Katzke, Verena, Schulze, Matthias, Palli, Domenico, Krogh, Vittorio, de Magistris, Maria Santucci, Tumino, Rosario, Ricceri, Fulvio, Gram, Inger T., Rylander, Charlotta, Skeie, Guri, Sánchez, Maria-Jose, Amiano, Pilar, Huerta, José María, Barricarte, Aurelio, Sartor, Hanna, Sonestedt, Emily, Esberg, Anders, Idahl, Annika, Mahamat-Saleh, Yahya, Laouali, Nasser, Kvaskoff, Marina, Turzanski-Fortner, Renée, Zamora-Ros, Raul, Londoño, Catalina, Cayssials, Valerie, de Villasante, Izar, Crous-Bou, Marta, Scalbert, Augustin, Weiderpass, Elisabete, Agudo, Antonio, Tjønneland, Anne, Olsen, Anja, Overvad, Kim, Katzke, Verena, Schulze, Matthias, Palli, Domenico, Krogh, Vittorio, de Magistris, Maria Santucci, Tumino, Rosario, Ricceri, Fulvio, Gram, Inger T., Rylander, Charlotta, Skeie, Guri, Sánchez, Maria-Jose, Amiano, Pilar, Huerta, José María, Barricarte, Aurelio, Sartor, Hanna, Sonestedt, Emily, Esberg, Anders, Idahl, Annika, Mahamat-Saleh, Yahya, Laouali, Nasser, Kvaskoff, Marina, Turzanski-Fortner, Renée, and Zamora-Ros, Raul
Abstract: Despite some epidemiological evidence on the protective effects of polyphenol intake on epithelial ovarian cancer (EOC) risk from case-control studies, the evidence is scarce from prospective studies and non-existent for several polyphenol classes. Therefore, we aimed to investigate the associations between the intake of total, classes and subclasses of polyphenols and EOC risk in a large prospective study. The study was conducted in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, which included 309,129 adult women recruited mostly from the general population. Polyphenol intake was assessed through validated country-specific dietary questionnaires and the Phenol-Explorer database. During a mean follow-up of 14 years, 1469 first incident EOC cases (including 806 serous, 129 endometrioid, 102 mucinous, and 67 clear cell tumours) were identified. In multivariable-adjusted Cox regression models, the hazard ratio in the highest quartile of total polyphenol intake compared with the lowest quartile (HRQ4vsQ1 ) was 1.14 (95% CI 0.94–1.39; p-trend = 0.11). Similarly, the intake of most classes and subclasses of polyphenols were not related to either overall EOC risk or any EOC subtype. A borderline statistically significant positive association was observed between phenolic acid intake (HRQ4vsQ1 = 1.20, 95% CI 1.01–1.43; p-trend = 0.02) and EOC risk, especially for the serous subtype and in women with obesity, although these associations did not exceed the Bonferroni correction threshold. The current results do not support any association between polyphenol intake and EOC in our large European prospective study. Results regarding phenolic acid intake need further investigation.
Published: 2021
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23. A comparison of complementary measures of vitamin B6 status, function, and metabolism in the European Prospective Investigation into Cancer and Nutrition (EPIC) study

Author: Clasen, Joanna L., Heath, Alicia K., Van Puyvelde, Heleen, Huybrechts, Inge, Park, Jin Young, Ferrari, Pietro, Johansson, Mattias, Scelo, Ghislaine, Ulvik, Arve, Midttun, Øivind, Ueland, Per Magne, Dahm, Christina C., Halkjær, Jytte, Olsen, Anja, Johnson, Theron, Katzke, Verena, Schulze, Matthias B., Masala, Giovanna, Segrado, Francesco, de Magistris, Maria Santucci, Sacerdote, Carlotta, Ocké, Marga C., Luján-Barroso, Leila, Ching-López, Ana, Huerta, José María, Ardanaz, Eva, Amiano, Pilar, Ericson, Ulrika, Manjer, Jonas, Gylling, Björn, Johansson, Ingegerd, Schmidt, Julie, Weiderpass, Elisabete, Riboli, Elio, Cross, Amanda J., Muller, David C., Clasen, Joanna L., Heath, Alicia K., Van Puyvelde, Heleen, Huybrechts, Inge, Park, Jin Young, Ferrari, Pietro, Johansson, Mattias, Scelo, Ghislaine, Ulvik, Arve, Midttun, Øivind, Ueland, Per Magne, Dahm, Christina C., Halkjær, Jytte, Olsen, Anja, Johnson, Theron, Katzke, Verena, Schulze, Matthias B., Masala, Giovanna, Segrado, Francesco, de Magistris, Maria Santucci, Sacerdote, Carlotta, Ocké, Marga C., Luján-Barroso, Leila, Ching-López, Ana, Huerta, José María, Ardanaz, Eva, Amiano, Pilar, Ericson, Ulrika, Manjer, Jonas, Gylling, Björn, Johansson, Ingegerd, Schmidt, Julie, Weiderpass, Elisabete, Riboli, Elio, Cross, Amanda J., and Muller, David C.
Abstract: BACKGROUND: Vitamin B6 insufficiency has been linked to increased risk of cancer and other chronic diseases. The circulating concentration of pyridoxal 5'-phosphate (PLP) is a commonly used measure of vitamin B6 status. Ratios of substrates indicating PLP coenzymatic function and metabolism may be useful complementary measures to further explore the role of vitamin B6 in health. OBJECTIVES: We explored the sensitivity of 5 outcomes, namely PLP concentration, homocysteine:cysteine (Hcy:Cys), cystathionine:cysteine (Cysta:Cys), the 3´-hydroxykynurenine ratio (HKr), and the 4-pyridoxic acid ratio (PAr) to vitamin B6 intake as well as personal and lifestyle characteristics. MEDTHODS: Dietary intake and biomarker data were collected from participants from 3 nested case-control studies within the European Prospective Investigation into Cancer and Nutrition (EPIC). Bayesian regression models assessed the associations of the 5 biomarker outcomes with vitamin B6 intake and personal and lifestyle covariates. Analogous models examined the relations of Hcy:Cys, Cysta:Cys, and HKr with PLP. RESULTS: In total, 4608 participants were included in the analyses. Vitamin B6 intake was most strongly associated with PLP, moderately associated with Hcy:Cys, Cysta:Cys, and HKr, and not associated with PAr (fold change in marker given a doubling of vitamin B6 intake: PLP 1.60 [95% credible interval (CrI): 1.50, 1.71]; Hcy:Cys 0.87 [95% CrI: 0.84, 0.90]; Cysta:Cys 0.89 [95% CrI: 0.84, 0.94]; HKr 0.88 [95% CrI: 0.85, 0.91]; PAr 1.00 [95% CrI: 0.95, 1.05]). PAr was most sensitive to age, and HKr was least sensitive to BMI and alcohol intake. Sex and menopause status were strongly associated with all 5 markers. CONCLUSIONS: We found that 5 different markers, capturing different aspects of vitamin B6-related biological processes, varied in their associations with vitamin B6 intake and personal and lifestyle predictors.
Published: 2021
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24. Association between nutritional profiles of foods underlying Nutri-Score front-of-pack labels and mortality: EPIC cohort study in 10 European countries

Author: Deschasaux, Mélanie, Huybrechts, Inge, Julia, Chantal, Hercberg, Serge, Egnell, Manon, Srour, Bernard, Kesse-Guyot, Emmanuelle, Latino-Martel, Paule, Biessy, Carine, Casagrande, Corinne, Murphy, Neil, Jenab, Mazda, Ward, Heather A, Weiderpass, Elisabete, Overvad, Kim, Tjønneland, Anne, Rostgaard-Hansen, Agnetha Linn, Boutron-Ruault, Marie-Christine, Mancini, Francesca Romana, Mahamat-Saleh, Yahya, Kühn, Tilman, Katzke, Verena, Bergmann, Manuela M, Schulze, Matthias B, Trichopoulou, Antonia, Karakatsani, Anna, Peppa, Eleni, Masala, Giovanna, Agnoli, Claudia, De Magistris, Maria Santucci, Tumino, Rosario, Sacerdote, Carlotta, Boer, Jolanda MA, Verschuren, WM Monique, van der Schouw, Yvonne T, Skeie, Guri, Braaten, Tonje, Redondo, M Luisa, Agudo, Antonio, Petrova, Dafina, Colorado-Yohar, Sandra M, Barricarte, Aurelio, Amiano, Pilar, Sonestedt, Emily, Ericson, Ulrika, Otten, Julia, Sundström, Björn, Wareham, Nicholas J, Forouhi, Nita G, Vineis, Paolo, Tsilidis, Konstantinos K, Knuppel, Anika, Papier, Keren, Ferrari, Pietro, Riboli, Elio, Gunter, Marc J, Touvier, Mathilde, Equipe 3: EREN- Equipe de Recherche en Epidémiologie Nutritionnelle (CRESS - U1153), Université Sorbonne Paris Nord-Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Réseau National Alimentation Cancer Recherche (réseau NACRe), Centre International de Recherche contre le Cancer - International Agency for Research on Cancer (CIRC - IARC), Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), Département de Santé Publique [Avicenne], Hôpital Avicenne [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), School of Public Health, Imperial College London, Aarhus University [Aarhus], Department of Public Health [Copenhagen], Faculty of Health and Medical Sciences, University of Copenhagen = Københavns Universitet (KU)-University of Copenhagen = Københavns Universitet (KU), Danish Cancer Society Research Center, Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Institut Gustave Roussy (IGR), German Cancer Research Center - Deutsches Krebsforschungszentrum [Heidelberg] (DKFZ), German Institute of Human Nutrition Potsdam-Rehbrücke (DIfE), Institute of Nutrition Science, University of Potsdam, Hellenic Health Foundation, 'Attikon' University Hospital, Institute for Cancer Research, Prevention and Clinical Network (ISPRO), Fondazione IRCCS Istituto Nazionale Tumori - National Cancer Institute [Milan], AOU Federico II, Partenaires INRAE, Provincial Health Services Authority, Center for Cancer Prevention (CPO-Piemonte), National Institute for Public Health and the Environment [Bilthoven] (RIVM), Julius Center for Health Sciences and Primary Care, University Medical Center [Utrecht], The Arctic University of Norway (UiT), Public Health Directorate, Institut d'Investigació Biomèdica de Bellvitge [Barcelone] (IDIBELL), Andalusian School of Public Health [Granada], Escuela Andaluza de Salud Publica, Instituto de Investigación Biosanitaria de Granada (Granada.ibs), Granada, Spain, parent, CIBER de Epidemiología y Salud Pública (CIBERESP), Murcia Regional Health Council [Murcia], Universidad de Antioquia = University of Antioquia [Medellín, Colombia], Navarra Public Health Institute, Navarra Institute for Health Research, Biodonostia Health Research Institute, Department of Clinical Sciences [Malmö, Suède], Lund University [Malmö, Suède], Department of Public Health and Clinical Medicine [Umeå, Sweden] (Environmental and Occupational Medicine), Umeå University, University of Cambridge School of Clinical Medicine, University of Ioannina School of Medicine, Nuffield Department of Population Health [Oxford], University of Oxford [Oxford], French National Cancer Institute (INCa)-Canceropole Ile-de-France 2017-1-PL SHS-01-INSERM ADR 5-1Fondation Recherche Medicale ARF201809007046European CommissionEuropean Commission Joint Research CentreInternational Agency for Research on CancerDanish Cancer SocietyLigue nationale contre le cancerInstitut Gustave RoussyMutuelle Generale de l'Education NationaleInstitut National de la Sante et de la Recherche Medicale (Inserm)Deutsche KrebshilfeFederal Ministry of Education & Research (BMBF)Hellenic Health Foundation (Greece)Associazione Italiana per la Ricerca sul Cancro (AIRC)Italian National Research CouncilDutch Ministry of Public Health, Welfare, and Sports (the Netherlands)Netherlands Cancer Registry (the Netherlands)Netherlands GovernmentHealth Research Fund (Spain)Instituto de Salud Carlos IIIJunta de Andalucia Regional government of Asturias (Spain) Regional government of Basque Country (Spain) Regional government of Murcia (Spain) Regional government of Navarra (Spain) Catalan Institute of Oncology (Spain)Swedish Cancer Society Swedish Scientific Council (Sweden) County councils of Skane and Vasterbotten (Sweden)Cancer Research UK C864/A14136 C8221/A19170Medical Research Council UK (MRC) MR/N003284/1 - MC-UU_12015/1 - MR/M012190/1 - MC_UU_12015/1 - MC_UU_12015/5 - National Institute for Health Research Biomedical Research Centre, Cambridge: Nutrition, Diet, and Lifestyle Research Theme IS-BRC-1215-20014, Deschasaux, Mélanie [0000-0002-3359-420X], and Apollo - University of Cambridge Repository
Subjects: Adult, Male, 1117 Public Health and Health Services, Cohort Studies, Food Preferences, Food Labeling, General & Internal Medicine, Surveys and Questionnaires, Mortalitat, Humans, Mortality, Nutrició, ComputingMilieux_MISCELLANEOUS, Nutrition, Proportional Hazards Models, Research, Klinisk medicin, 1103 Clinical Sciences, Middle Aged, Europe, Nutrition Assessment, Female, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Clinical Medicine, Nutritive Value, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition
Abstract: Objective: To determine if the Food Standards Agency nutrient profiling system (FSAm-NPS), which grades the nutritional quality of food products and is used to derive the Nutri-Score front-of-packet label to guide consumers towards healthier food choices, is associated with mortality. Design: Population based cohort study. Setting: European Prospective Investigation into Cancer and Nutrition (EPIC) cohort from 23 centres in 10 European countries. Participants: 521 324 adults; at recruitment, country specific and validated dietary questionnaires were used to assess their usual dietary intakes. A FSAm-NPS score was calculated for each food item per 100 g content of energy, sugars, saturated fatty acids, sodium, fibre, and protein, and of fruit, vegetables, legumes, and nuts. The FSAm-NPS dietary index was calculated for each participant as an energy weighted mean of the FSAm-NPS score of all foods consumed. The higher the score the lower the overall nutritional quality of the diet. Main outcome measure: Associations between the FSAm-NPS dietary index score and mortality, assessed using multivariable adjusted Cox proportional hazards regression models. Results: After exclusions, 501 594 adults (median follow-up 17.2 years, 8 162 730 person years) were included in the analyses. Those with a higher FSAm-NPS dietary index score (highest versus lowest fifth) showed an increased risk of all cause mortality (n=53 112 events from non-external causes; hazard ratio 1.07, 95% confidence interval 1.03 to 1.10, PConclusions: In this large multinational European cohort, consuming foods with a higher FSAm-NPS score (lower nutritional quality) was associated with a higher mortality for all causes and for cancer and diseases of the circulatory, respiratory, and digestive systems, supporting the relevance of FSAm-NPS to characterise healthier food choices in the context of public health policies (eg, the Nutri-Score) for European populations. This is important considering ongoing discussions about the potential implementation of a unique nutrition labelling system at the European Union level.
Published: 2020

25. Association between nutritional profiles of foods underlying Nutri-Score front-of-pack labels and mortality:EPIC cohort study in 10 European countries

Author: Deschasaux, Mélanie, Huybrechts, Inge, Julia, Chantal, Hercberg, Serge, Egnell, Manon, Srour, Bernard, Kesse-Guyot, Emmanuelle, Latino-Martel, Paule, Biessy, Carine, Casagrande, Corinne, Murphy, Neil, Jenab, Mazda, Ward, Heather A., Weiderpass, Elisabete, Overvad, Kim, Tjønneland, Anne, Rostgaard-Hansen, Agnetha Linn, Boutron-Ruault, Marie Christine, Mancini, Francesca Romana, Mahamat-Saleh, Yahya, Kühn, Tilman, Katzke, Verena, Bergmann, Manuela M., Schulze, Matthias B., Trichopoulou, Antonia, Karakatsani, Anna, Peppa, Eleni, Masala, Giovanna, Agnoli, Claudia, De Magistris, Maria Santucci, Tumino, Rosario, Sacerdote, Carlotta, Boer, Jolanda Ma, Verschuren, Wm Monique, van der Schouw, Yvonne T., Skeie, Guri, Braaten, Tonje, Redondo, M. Luisa, Agudo, Antonio, Petrova, Dafina, Colorado-Yohar, Sandra M., Barricarte, Aurelio, Amiano, Pilar, Sonestedt, Emily, Ericson, Ulrika, Otten, Julia, Sundström, Björn, Wareham, Nicholas J., Forouhi, Nita G., Vineis, Paolo, Tsilidis, Konstantinos K., Knuppel, Anika, Papier, Keren, Ferrari, Pietro, Riboli, Elio, Gunter, Marc J., Touvier, Mathilde, Deschasaux, Mélanie, Huybrechts, Inge, Julia, Chantal, Hercberg, Serge, Egnell, Manon, Srour, Bernard, Kesse-Guyot, Emmanuelle, Latino-Martel, Paule, Biessy, Carine, Casagrande, Corinne, Murphy, Neil, Jenab, Mazda, Ward, Heather A., Weiderpass, Elisabete, Overvad, Kim, Tjønneland, Anne, Rostgaard-Hansen, Agnetha Linn, Boutron-Ruault, Marie Christine, Mancini, Francesca Romana, Mahamat-Saleh, Yahya, Kühn, Tilman, Katzke, Verena, Bergmann, Manuela M., Schulze, Matthias B., Trichopoulou, Antonia, Karakatsani, Anna, Peppa, Eleni, Masala, Giovanna, Agnoli, Claudia, De Magistris, Maria Santucci, Tumino, Rosario, Sacerdote, Carlotta, Boer, Jolanda Ma, Verschuren, Wm Monique, van der Schouw, Yvonne T., Skeie, Guri, Braaten, Tonje, Redondo, M. Luisa, Agudo, Antonio, Petrova, Dafina, Colorado-Yohar, Sandra M., Barricarte, Aurelio, Amiano, Pilar, Sonestedt, Emily, Ericson, Ulrika, Otten, Julia, Sundström, Björn, Wareham, Nicholas J., Forouhi, Nita G., Vineis, Paolo, Tsilidis, Konstantinos K., Knuppel, Anika, Papier, Keren, Ferrari, Pietro, Riboli, Elio, Gunter, Marc J., and Touvier, Mathilde
Abstract: Objective: To determine if the Food Standards Agency nutrient profiling system (FSAm-NPS), which grades the nutritional quality of food products and is used to derive the Nutri-Score front-of-packet label to guide consumers towards healthier food choices, is associated with mortality. Design: Population based cohort study. Setting: European Prospective Investigation into Cancer and Nutrition (EPIC) cohort from 23 centres in 10 European countries. Participants: 521 324 adults; at recruitment, country specific and validated dietary questionnaires were used to assess their usual dietary intakes. A FSAm-NPS score was calculated for each food item per 100 g content of energy, sugars, saturated fatty acids, sodium, fibre, and protein, and of fruit, vegetables, legumes, and nuts. The FSAm-NPS dietary index was calculated for each participant as an energy weighted mean of the FSAm-NPS score of all foods consumed. The higher the score the lower the overall nutritional quality of the diet. Main outcome measure: Associations between the FSAm-NPS dietary index score and mortality, assessed using multivariable adjusted Cox proportional hazards regression models. Results: After exclusions, 501 594 adults (median follow-up 17.2 years, 8 162 730 person years) were included in the analyses. Those with a higher FSAm-NPS dietary index score (highest versus lowest fifth) showed an increased risk of all cause mortality (n=53 112 events from non-external causes; hazard ratio 1.07, 95% confidence interval 1.03 to 1.10, P<0.001 for trend) and mortality from cancer (1.08, 1.03 to 1.13, P<0.001 for trend) and diseases of the circulatory (1.04, 0.98 to 1.11, P=0.06 for trend), respiratory (1.39, 1.22 to 1.59, P<0.001), and digestive (1.22, 1.02 to 1.45, P=0.03 for trend) systems. The age standardised absolute rates for all cause mortality per 10 000 persons over 10 years were 760 (men=1237; women=563) for
Published: 2020

26. A metabolomic study of red and processed meat intake and acylcarnitine concentrations in human urine and blood

Author: Wedekind, Roland, primary, Kiss, Agneta, additional, Keski-Rahkonen, Pekka, additional, Viallon, Vivian, additional, Rothwell, Joseph A, additional, Cross, Amanda J, additional, Rostgaard-Hansen, Agnetha Linn, additional, Sandanger, Torkjel M, additional, Jakszyn, Paula, additional, Schmidt, Julie A, additional, Pala, Valeria, additional, Vermeulen, Roel, additional, Schulze, Matthias B, additional, Kühn, Tilman, additional, Johnson, Theron, additional, Trichopoulou, Antonia, additional, Peppa, Eleni, additional, La Vechia, Carlo, additional, Masala, Giovanna, additional, Tumino, Rosario, additional, Sacerdote, Carlotta, additional, Wittenbecher, Clemens, additional, de Magistris, Maria Santucci, additional, Dahm, Christina C, additional, Severi, Gianluca, additional, Mancini, Francesca Romana, additional, Weiderpass, Elisabete, additional, Gunter, Marc J, additional, Huybrechts, Inge, additional, and Scalbert, Augustin, additional
Published: 2020
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27. Plasma phospholipid fatty acid profiles and their association with food intakes: results from a cross-sectional study within the European Prospective Investigation into Cancer and Nutrition1–3

Author: Saadatian-Elahi, Mitra, Slimani, Nadia, Chajès, Véronique, Jenab, Mazda, Goudable, Joëlle, Biessy, Carine, Ferrari, Pietro, Byrnes, Graham, Autier, Philippe, Peeters, Petra HM, Ocké, Marga, de Mesquita, Bas Bueno, Johansson, Ingegerd, Hallmans, Goran, Manjer, Jonas, Wirfält, Elisabet, Gonzalez, Carlos A, Navarro, Carmen, Martinez, Carmen, Amiano, Pilar, Suárez, Laudina Rodriguez, Ardanaz, Eva, Tjønneland, Anne, Halkjaer, Jytte, Overvad, Kim, Jakobsen, Marianne Uhre, Berrino, Franco, Pala, Valeria, Palli, Domenico, Tumino, Rosario, Vineis, Paolo, de Magistris, Maria Santucci, Spencer, Elisabeth A, Crowe, Francesca L, Bingham, Sheila, Khaw, Kay-Tee, Linseisen, Jakob, Rohrmann, Sabine, Boeing, Heiner, Noethlings, Ute, Olsen, Karina Standahl, Skeie, Guri, Lund, Eiliv, Trichopoulou, Antonia, Oustoglou, Erifili, Clavel-Chapelon, Françoise, and Riboli, Elio
Published: 2009
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28. Dietary intake of animal and plant proteins and risk of all cause and cause-specific mortality: The Epic-Italy cohort.

Author: Fontana, Luigi, Sieri, Sabina, Ricceri, Fulvio, Agnoli, Claudia, Pala, Valeria, Masala, Giovanna, Saieva, Calogero, Catalano, Alberto, Macciotta, Alessandra, Tumino, Rosario, Panico, Salvatore, De Magistris, Maria Santucci, and Krogh, Vittorio
Subjects: PLANT proteins, LDL cholesterol, PLANT mortality, MEDITERRANEAN diet, MIDDLE-aged men, MIDDLE-aged persons, FOOD consumption, CARBOHYDRATE content of food
Abstract: BACKGROUND: To examine the associations of animal and plant protein intake with all-cause, cardiovascular and cancer mortality risk in middle-aged Italian men and women with substantially lower animal protein intake than North Americans. METHODS AND RESULTS: Food consumption was assessed by validated Epic semiquantitative FFQs. Multivariable Cox models stratified by center, age, and sex, and adjusted for confounders, estimated associations of animal and plant protein consumption with mortality for all causes, cardiovascular disease, and cancer. After a median follow-up of 15.2 years, 2,449 deaths were identified in 45,009 participants. No significant association between intake of total, animal or plant protein and mortality was found in the fully adjusted models. Substitution of plant protein for animal protein was inversely associated with cardiovascular mortality (HR, 0.47; 95% CI, 0.24–0.92) only in people with at least 1 unhealthy lifestyle risk factor and poor adherence to a Mediterranean diet. Participants in the highest quintile group of animal protein intake had higher glucose, total and LDL cholesterol levels than those in the lowest quintile. In contrast, higher plant protein intake was negatively associated with fasting insulin and cholesterol, despite higher BMI, physical inactivity and starch consumption. CONCLUSIONS: Replacing plant protein for animal protein was associated with lower cardiovascular mortality among individuals with unhealthy lifestyle risk factors. High animal but not plant protein intake is associated with impaired fasting glucose and hypercholesterolemia, despite lower calorie and carbohydrate intake, suggesting that protein source plays crucial roles in modulating cardiometabolic health independently of body weight. [ABSTRACT FROM AUTHOR]
Published: 2021
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29. Coffee and Tea Consumption and the Contribution of Their Added Ingredients to Total Energy and Nutrient Intakes in 10 European Countries : Benchmark Data from the Late 1990s

Author: Landais, Edwige, Moskal, Aurelie, Mullee, Amy, Nicolas, Genevieve, Gunter, Marc J., Huybrechts, Inge, Overvad, Kim, Roswall, Nina, Affret, Aurelie, Fagherazzi, Guy, Mahamat-Saleh, Yahya, Katzke, Verena, Kuehn, Tilman, La Vecchia, Carlo, Trichopoulou, Antonia, Valanou, Elissavet, Saieva, Calogero, de Magistris, Maria Santucci, Sieri, Sabina, Braaten, Tonje, Skeie, Guri, Weiderpass, Elisabete, Ardanaz, Eva, Chirlaque, Maria-Dolores, Garcia, Jose Ramon, Jakszyn, Paula, Rodriguez-Barranco, Miguel, Brunkwall, Louise, Huseinovic, Ena, Nilsson, Lena, Wallström, Peter, Bueno-de-Mesquita, Bas, Peeters, Petra H., Aune, Dagfinn, Key, Tim, Lentjes, Marleen, Riboli, Elio, Slimani, Nadia, Freisling, Heinz, Landais, Edwige, Moskal, Aurelie, Mullee, Amy, Nicolas, Genevieve, Gunter, Marc J., Huybrechts, Inge, Overvad, Kim, Roswall, Nina, Affret, Aurelie, Fagherazzi, Guy, Mahamat-Saleh, Yahya, Katzke, Verena, Kuehn, Tilman, La Vecchia, Carlo, Trichopoulou, Antonia, Valanou, Elissavet, Saieva, Calogero, de Magistris, Maria Santucci, Sieri, Sabina, Braaten, Tonje, Skeie, Guri, Weiderpass, Elisabete, Ardanaz, Eva, Chirlaque, Maria-Dolores, Garcia, Jose Ramon, Jakszyn, Paula, Rodriguez-Barranco, Miguel, Brunkwall, Louise, Huseinovic, Ena, Nilsson, Lena, Wallström, Peter, Bueno-de-Mesquita, Bas, Peeters, Petra H., Aune, Dagfinn, Key, Tim, Lentjes, Marleen, Riboli, Elio, Slimani, Nadia, and Freisling, Heinz
Abstract: Background: Coffee and tea are among the most commonly consumed nonalcoholic beverages worldwide, but methodological differences in assessing intake often hamper comparisons across populations. We aimed to (i) describe coffee and tea intakes and (ii) assess their contribution to intakes of selected nutrients in adults across 10 European countries. Method: Between 1995 and 2000, a standardized 24-h dietary recall was conducted among 36,018 men and women from 27 European Prospective Investigation into Cancer and Nutrition (EPIC) study centres. Adjusted arithmetic means of intakes were estimated in grams (=volume) per day by sex and centre. Means of intake across centres were compared by sociodemographic characteristics and lifestyle factors. Results: In women, the mean daily intake of coffee ranged from 94 g/day (similar to 0.6 cups) in Greece to 781 g/day (similar to 4.4 cups) in Aarhus (Denmark), and tea from 14 g/day (similar to 0.1 cups) in Navarra (Spain) to 788 g/day (similar to 4.3 cups) in the UK general population. Similar geographical patterns for mean daily intakes of both coffee and tea were observed in men. Current smokers as compared with those who reported never smoking tended to drink on average up to 500 g/day more coffee and tea combined, but with substantial variation across centres. Other individuals' characteristics such as educational attainment or age were less predictive. In all centres, coffee and tea contributed to less than 10% of the energy intake. The greatest contribution to total sugar intakes was observed in Southern European centres (up to similar to 20%). Conclusion: Coffee and tea intake and their contribution to energy and sugar intake differed greatly among European adults. Variation in consumption was mostly driven by geographical region.
Published: 2018
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30. Consumption of fruits, vegetables and fruit juices and differentiated thyroid carcinoma risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study

Author: Zamora-Ros, Raul, Beraud, Virginie, Franceschi, Silvia, Cayssials, Valerie, Tsilidis, Konstantinos K., Boutron-Ruault, Marie-Christine, Weiderpass, Elisabete, Overvad, Kim, Tjonneland, Anne, Eriksen, Anne K., Bonnet, Fabrice, Affret, Aurelie, Katzke, Verena, Kuehn, Tilman, Boeing, Heiner, Trichopoulou, Antonia, Valanou, Elisavet, Karakatsani, Anna, Masala, Giovanna, Grioni, Sara, de Magistris, Maria Santucci, Tumino, Rosario, Ricceri, Fulvio, Skeie, Guri, Parr, Christine L., Merino, Susana, Salamanca-Fernandez, Elena, Chirlaque, Maria-Dolores, Ardanaz, Eva, Amiano, Pilar, Almquist, Martin, Drake, Isabel, Hennings, Joakim, Sandström, Maria, Bueno-de-Mesquita, H. B(as), Peeters, Petra H., Khaw, Kay-Thee, Wareham, Nicholas J., Schmidt, Julie A., Perez-Cornago, Aurora, Aune, Dagfinn, Riboli, Elio, Slimani, Nadia, Scalbert, Augustin, Romieu, Isabelle, Agudo, Antonio, Rinaldi, Sabina, Zamora-Ros, Raul, Beraud, Virginie, Franceschi, Silvia, Cayssials, Valerie, Tsilidis, Konstantinos K., Boutron-Ruault, Marie-Christine, Weiderpass, Elisabete, Overvad, Kim, Tjonneland, Anne, Eriksen, Anne K., Bonnet, Fabrice, Affret, Aurelie, Katzke, Verena, Kuehn, Tilman, Boeing, Heiner, Trichopoulou, Antonia, Valanou, Elisavet, Karakatsani, Anna, Masala, Giovanna, Grioni, Sara, de Magistris, Maria Santucci, Tumino, Rosario, Ricceri, Fulvio, Skeie, Guri, Parr, Christine L., Merino, Susana, Salamanca-Fernandez, Elena, Chirlaque, Maria-Dolores, Ardanaz, Eva, Amiano, Pilar, Almquist, Martin, Drake, Isabel, Hennings, Joakim, Sandström, Maria, Bueno-de-Mesquita, H. B(as), Peeters, Petra H., Khaw, Kay-Thee, Wareham, Nicholas J., Schmidt, Julie A., Perez-Cornago, Aurora, Aune, Dagfinn, Riboli, Elio, Slimani, Nadia, Scalbert, Augustin, Romieu, Isabelle, Agudo, Antonio, and Rinaldi, Sabina
Abstract: Fruit and vegetable (F&V) intake is considered as probably protective against overall cancer risk, but results in previous studies are not consistent for thyroid cancer (TC). The purpose of this study is to examine the association between the consumption of fruits, vegetables, fruit juices and differentiated thyroid cancer risk within the European Prospective Investigation into Cancer and Nutrition (EPIC) study. The EPIC study is a cohort including over half a million participants, recruited between 1991 and 2000. During a mean follow-up of 14 years, 748 incident first primary differentiated TC cases were identified. F&V and fruit juice intakes were assessed through validated country-specific dietary questionnaires. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox regression models adjusted for potential confounding factors. Comparing the highest versus lowest quartile of intake, differentiated TC risk was not associated with intakes of total F&V (HR: 0.89; 95% CI: 0.68-1.15; p-trend=0.44), vegetables (HR: 0.89; 95% CI: 0.69-1.14; p-trend=0.56), or fruit (HR: 1.00; 95% CI: 0.79-1.26; p-trend=0.64). No significant association was observed with any individual type of vegetable or fruit. However, there was a positive borderline trend with fruit juice intake (HR: 1.23; 95% CI: 0.98-1.53; p-trend=0.06). This study did not find any significant association between F&V intakes and differentiated TC risk; however a positive trend with fruit juice intake was observed, possibly related to its high sugar content.
Published: 2018
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31. Coffee and tea consumption and the contribution of their added ingredients to total energy and nutrient intakes in 10 European countries: Benchmark data from the late 1990s

Author: MS MDL 1, Epi Kanker Team 1, Cancer, JC onderzoeksprogramma Kanker, Landais, Edwige, Moskal, Aurélie, Mullee, Amy, Nicolas, Geneviève, Gunter, Marc J., Huybrechts, Inge, Overvad, Kim, Roswall, Nina, Affret, Aurélie, Fagherazzi, Guy, Mahamat-Saleh, Yahya, Katzke, Verena, Kühn, Tilman, la Vecchia, Carlo, Trichopoulou, Antonia, Valanou, Elissavet, Saieva, Calogero, de Magistris, Maria Santucci, Sieri, Sabina, Braaten, Tonje, Skeie, Guri, Weiderpass, Elisabete, Ardanaz, Eva, Chirlaque, Maria Dolores, Garcia, Jose Ramon, Jakszyn, Paula, Rodríguez-Barranco, Miguel, Brunkwall, Louise, Huseinovic, Ena, Nilsson, Lena, Wallström, Peter, Bueno-De-Mesquita, Bas, Peeters, Petra H., Aune, Dagfinn, Key, Tim, Lentjes, Marleen, Riboli, Elio, Slimani, Nadia, Freisling, Heinz, MS MDL 1, Epi Kanker Team 1, Cancer, JC onderzoeksprogramma Kanker, Landais, Edwige, Moskal, Aurélie, Mullee, Amy, Nicolas, Geneviève, Gunter, Marc J., Huybrechts, Inge, Overvad, Kim, Roswall, Nina, Affret, Aurélie, Fagherazzi, Guy, Mahamat-Saleh, Yahya, Katzke, Verena, Kühn, Tilman, la Vecchia, Carlo, Trichopoulou, Antonia, Valanou, Elissavet, Saieva, Calogero, de Magistris, Maria Santucci, Sieri, Sabina, Braaten, Tonje, Skeie, Guri, Weiderpass, Elisabete, Ardanaz, Eva, Chirlaque, Maria Dolores, Garcia, Jose Ramon, Jakszyn, Paula, Rodríguez-Barranco, Miguel, Brunkwall, Louise, Huseinovic, Ena, Nilsson, Lena, Wallström, Peter, Bueno-De-Mesquita, Bas, Peeters, Petra H., Aune, Dagfinn, Key, Tim, Lentjes, Marleen, Riboli, Elio, Slimani, Nadia, and Freisling, Heinz
Published: 2018

32. Dietary and lifestyle determinants of acrylamide and glycidamide hemoglobin adducts in non-smoking postmenopausal women from the EPIC cohort

Author: Obon-Santacana, Mireia Lujan-Barroso, Leila Freisling, Heinz and Cadeau, Claire Fagherazzi, Guy Boutron-Ruault, Marie-Christine and Kaaks, Rudolf Fortner, Renee T. Boeing, Heiner Quiros, J. Ramon Molina-Montes, Esther Chamosa, Saioa Castano, Jose Maria Huerta Ardanaz, Eva Khaw, Kay-Tee Wareham, Nick and Key, Tim Trichopoulou, Antonia Lagiou, Pagona Naska, Androniki Palli, Domenico Grioni, Sara Tumino, Rosario and Vineis, Paolo De Magistris, Maria Santucci Bueno-de-Mesquita, H. B. Peeters, Petra H. Wennberg, Maria Bergdahl, Ingvar A. and Vesper, Hubert Riboli, Elio Duell, Eric J.
Abstract: Purpose Acrylamide was classified as ‘probably carcinogenic’ to humans in 1994 by the International Agency for Research on Cancer. In 2002, public health concern increased when acrylamide was identified in starchy, plant-based foods, processed at high temperatures. The purpose of this study was to identify which food groups and lifestyle variables were determinants of hemoglobin adduct concentrations of acrylamide ( HbAA) and glycidamide (HbGA) in 801 non-smoking postmenopausal women from eight countries in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Methods Biomarkers of internal exposure were measured in red blood cells (collected at baseline) by high-performance liquid chromatography/tandem mass spectrometry (HPLC/MS/MS). In this cross-sectional analysis, four dependent variables were evaluated: HbAA, HbGA, sum of total adducts (HbAA + HbGA), and their ratio (HbGA/HbAA). Simple and multiple regression analyses were used to identify determinants of the four outcome variables. All dependent variables (except HbGA/HbAA) and all independent variables were log-transformed (log2) to improve normality. Median (25th-75th percentile) HbAA and HbGA adduct levels were 41.3 (32.8-53.1) pmol/g Hb and 34.2 (25.4-46.9) pmol/g Hb, respectively. Results The main food group determinants of HbAA, HbGA, and HbAA + HbGA were biscuits, crackers, and dry cakes. Alcohol intake and body mass index were identified as the principal determinants of HbGA/HbAA. The total percent variation in HbAA, HbGA, HbAA + HbGA, and HbGA/HbAA explained in this study was 30, 26, 29, and 13 %, respectively. Conclusions Dietary and lifestyle factors explain a moderate proportion of acrylamide adduct variation in nonsmoking postmenopausal women from the EPIC cohort.
Published: 2017

33. Identification of Urinary Polyphenol Metabolite Patterns Associated with Polyphenol-Rich Food Intake in Adults from Four European Countries

Author: Noh, Hwayoung Freisling, Heinz Assi, Nada Zamora-Ros, Raul and Achaintre, David Affret, Aurelie Mancini, Francesca and Boutron-Ruault, Marie-Christine Floegel, Anna Boeing, Heiner and Kuehn, Tilman Schuebel, Ruth Trichopoulou, Antonia Naska, Androniki Kritikou, Maria Palli, Domenico Pala, Valeria and Tumino, Rosario Ricceri, Fulvio de Magistris, Maria Santucci and Cross, Amanda Slimani, Nadia Scalbert, Augustin Ferrari, Pietro
Subjects: food and beverages
Abstract: We identified urinary polyphenol metabolite patterns by a novel algorithm that combines dimension reduction and variable selection methods to explain polyphenol-rich food intake, and compared their respective performance with that of single biomarkers in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. The study included 475 adults from four European countries (Germany, France, Italy, and Greece). Dietary intakes were assessed with 24-h dietary recalls (24-HDR) and dietary questionnaires (DQ). Thirty-four polyphenols were measured by ultra-performance liquid chromatography-electrospray ionization-tandem mass spectrometry (UPLC-ESI-MS-MS) in 24-h urine. Reduced rank regression-based variable importance in projection (RRR-VIP) and least absolute shrinkage and selection operator (LASSO) methods were used to select polyphenol metabolites. Reduced rank regression (RRR) was then used to identify patterns in these metabolites, maximizing the explained variability in intake of pre-selected polyphenol-rich foods. The performance of RRR models was evaluated using internal cross-validation to control for over-optimistic findings from over-fitting. High performance was observed for explaining recent intake (24-HDR) of red wine (r = 0.65; AUC = 89.1%), coffee (r = 0.51; AUC = 89.1%), and olives (r = 0.35; AUC = 82.2%). These metabolite patterns performed better or equally well compared to single polyphenol biomarkers. Neither metabolite patterns nor single biomarkers performed well in explaining habitual intake (as reported in the DQ) of polyphenol-rich foods. This proposed strategy of biomarker pattern identification has the potential of expanding the currently still limited list of available dietary intake biomarkers.
Published: 2017

34. Dietary flavonoid intake and colorectal cancer risk in the European prospective investigation into cancer and nutrition (EPIC) cohort

Author: Zamora-Ros, Raul Barupal, Dinesh K. Rothwell, Joseph A. and Jenab, Mazda Fedirko, Veronika Romieu, Isabelle and Aleksandrova, Krasimira Overvad, Kim Kyro, Cecilie and Tjonneland, Anne Affret, Aurelie His, Mathilde and Boutron-Ruault, Marie-Christine Katzke, Verena Kuehn, Tilman and Boeing, Heiner Trichopoulou, Antonia Naska, Androniki and Kritikou, Maria Saieva, Calogero Agnoli, Claudia de Magistris, Maria Santucci Tumino, Rosario Fasanelli, Francesca and Weiderpass, Elisabete Skeie, Guri Merino, Susana and Jakszyn, Paula Sanchez, Maria-Jose Dorronsoro, Miren and Navarro, Carmen Ardanaz, Eva Sonestedt, Emily Ericson, Ulrika Nilsson, Lena Maria Boden, Stina Bueno-de-Mesquita, H. B. (as) Peeters, Petra H. Perez-Cornago, Aurora Wareham, Nicholas J. Khaw, Kay-Thee Freisling, Heinz Cross, Amanda J. and Riboli, Elio Scalbert, Augustin
Subjects: fungi, food and beverages, heterocyclic compounds
Abstract: Flavonoids have been shown to inhibit colon cancer cell proliferation in vitro and protect against colorectal carcinogenesis in animal models. However, epidemiological evidence on the potential role of flavonoid intake in colorectal cancer (CRC) development remains sparse and inconsistent. We evaluated the association between dietary intakes of total flavonoids and their subclasses and risk of development of CRC, within the European Prospective Investigation into Cancer and Nutrition (EPIC) study. A cohort of 477,312 adult men and women were recruited in 10 European countries. At baseline, dietary intakes of total flavonoids and individual subclasses were estimated using centre-specific validated dietary questionnaires and composition data from the Phenol-Explorer database. During an average of 11 years of follow-up, 4,517 new cases of primary CRC were identified, of which 2,869 were colon (proximal = 1,298 and distal = 1,266) and 1,648 rectal tumours. No association was found between total flavonoid intake and the risk of overall CRC (HR for comparison of extreme quintiles 1.05, 95% CI 0.93-1.18; p-trend = 0.58) or any CRC subtype. No association was also observed with any intake of individual flavonoid subclasses. Similar results were observed for flavonoid intake expressed as glycosides or aglycone equivalents. Intake of total flavonoids and flavonoid subclasses, as estimated from dietary questionnaires, did not show any association with risk of CRC development.
Published: 2017

35. Association between plasma phospholipid saturated fatty acids and metabolic markers of lipid, hepatic, inflammation and glycaemic pathways in eight European countries : a cross-sectional analysis in the EPIC-InterAct study

Author: Zheng, Ju-Sheng, Sharp, Stephen J., Imamura, Fumiaki, Koulman, Albert, Schulze, Matthias B., Ye, Zheng, Griffin, Jules, Guevara, Marcela, María Huerta, José, Kröger, Janine, Sluijs, Ivonne, Agudo, Antonio, Barricarte, Aurelio, Boeing, Heiner, Colorado-Yohar, Sandra, Dow, Courtney, Dorronsoro, Miren, Dinesen, Pia T., Fagherazzi, Guy, Franks, Paul W., Feskens, Edith J. M., Kühn, Tilman, Katzke, Verena Andrea, Key, Timothy J., Khaw, Kay-Tee, de Magistris, Maria Santucci, Romana Mancini, Francesca, Molina-Portillo, Elena, Nilsson, Peter M., Olsen, Anja, Overvad, Kim, Palli, Domenico, Ramón Quirós, Jose, Rolandsson, Olov, Ricceri, Fulvio, Spijkerman, Annemieke M. W., Slimani, Nadia, Tagliabue, Giovanna, Tjonneland, Anne, Tumino, Rosario, van der Schouw, Yvonne T., Langenberg, Claudia, Riboli, Elio, Forouhi, Nita G., Wareham, Nicholas J., Zheng, Ju-Sheng, Sharp, Stephen J., Imamura, Fumiaki, Koulman, Albert, Schulze, Matthias B., Ye, Zheng, Griffin, Jules, Guevara, Marcela, María Huerta, José, Kröger, Janine, Sluijs, Ivonne, Agudo, Antonio, Barricarte, Aurelio, Boeing, Heiner, Colorado-Yohar, Sandra, Dow, Courtney, Dorronsoro, Miren, Dinesen, Pia T., Fagherazzi, Guy, Franks, Paul W., Feskens, Edith J. M., Kühn, Tilman, Katzke, Verena Andrea, Key, Timothy J., Khaw, Kay-Tee, de Magistris, Maria Santucci, Romana Mancini, Francesca, Molina-Portillo, Elena, Nilsson, Peter M., Olsen, Anja, Overvad, Kim, Palli, Domenico, Ramón Quirós, Jose, Rolandsson, Olov, Ricceri, Fulvio, Spijkerman, Annemieke M. W., Slimani, Nadia, Tagliabue, Giovanna, Tjonneland, Anne, Tumino, Rosario, van der Schouw, Yvonne T., Langenberg, Claudia, Riboli, Elio, Forouhi, Nita G., and Wareham, Nicholas J.
Abstract: Background: Accumulating evidence suggests that individual circulating saturated fatty acids (SFAs) are heterogeneous in their associations with cardio-metabolic diseases, but evidence about associations of SFAs with metabolic markers of different pathogenic pathways is limited. We aimed to examine the associations between plasma phospholipid SFAs and the metabolic markers of lipid, hepatic, glycaemic and inflammation pathways. Methods: We measured nine individual plasma phospholipid SFAs and derived three SFA groups (odd-chain: C15:0 + C17:0, even-chain: C14:0 + C16:0 + C18:0, and very-long-chain: C20:0 + C22:0 + C23:0 + C24:0) in individuals from the subcohort of the European Prospective Investigation into Cancer and Nutrition (EPIC)-InterAct case-cohort study across eight European countries. Using linear regression in 15,919 subcohort members, adjusted for potential confounders and corrected for multiple testing, we examined cross-sectional associations of SFAs with 13 metabolic markers. Multiplicative interactions of the three SFA groups with pre-specified factors, including body mass index (BMI) and alcohol consumption, were tested. Results: Higher levels of odd-chain SFA group were associated with lower levels of major lipids (total cholesterol (TC), triglycerides, apolipoprotein A-1 (ApoA1), apolipoprotein B (ApoB)) and hepatic markers (alanine transaminase (ALT), aspartate transaminase (AST), gamma-glutamyl transferase (GGT)). Higher even-chain SFA group levels were associated with higher levels of low-density lipoprotein cholesterol (LDL-C), TC/high-density lipoprotein cholesterol (HDL-C) ratio, triglycerides, ApoB, ApoB/A1 ratio, ALT, AST, GGT and CRP, and lower levels of HDL-C and ApoA1. Very-long-chain SFA group levels showed inverse associations with triglycerides, ApoA1 and GGT, and positive associations with TC, LDL-C, TC/HDL-C, ApoB and ApoB/A1. Associations were generally stronger at higher levels of BMI or alcohol consumption. Conclusions: Subtypes
Published: 2017
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36. Dietary flavonoid intake and colorectal cancer risk in the European prospective investigation into cancer and nutrition (EPIC) cohort

Author: Zamora-Ros, Raul, Barupal, Dinesh K., Rothwell, Joseph A., Jenab, Mazda, Fedirko, Veronika, Romieu, Isabelle, Aleksandrova, Krasimira, Overvad, Kim, Kyro, Cecilie, Tjonneland, Anne, Affret, Aurelie, His, Mathilde, Boutron-Ruault, Marie-Christine, Katzke, Verena, Kuehn, Tilman, Boeing, Heiner, Trichopoulou, Antonia, Naska, Androniki, Kritikou, Maria, Saieva, Calogero, Agnoli, Claudia, de Magistris, Maria Santucci, Tumino, Rosario, Fasanelli, Francesca, Weiderpass, Elisabete, Skeie, Guri, Merino, Susana, Jakszyn, Paula, Sanchez, Maria-Jose, Dorronsoro, Miren, Navarro, Carmen, Ardanaz, Eva, Sonestedt, Emily, Ericson, Ulrika, Nilsson, Lena Maria, Bodén, Stina, Bueno-de-Mesquita, H. B. (as), Peeters, Petra H., Perez-Cornago, Aurora, Wareham, Nicholas J., Khaw, Kay-Thee, Freisling, Heinz, Cross, Amanda J., Riboli, Elio, Scalbert, Augustin, Zamora-Ros, Raul, Barupal, Dinesh K., Rothwell, Joseph A., Jenab, Mazda, Fedirko, Veronika, Romieu, Isabelle, Aleksandrova, Krasimira, Overvad, Kim, Kyro, Cecilie, Tjonneland, Anne, Affret, Aurelie, His, Mathilde, Boutron-Ruault, Marie-Christine, Katzke, Verena, Kuehn, Tilman, Boeing, Heiner, Trichopoulou, Antonia, Naska, Androniki, Kritikou, Maria, Saieva, Calogero, Agnoli, Claudia, de Magistris, Maria Santucci, Tumino, Rosario, Fasanelli, Francesca, Weiderpass, Elisabete, Skeie, Guri, Merino, Susana, Jakszyn, Paula, Sanchez, Maria-Jose, Dorronsoro, Miren, Navarro, Carmen, Ardanaz, Eva, Sonestedt, Emily, Ericson, Ulrika, Nilsson, Lena Maria, Bodén, Stina, Bueno-de-Mesquita, H. B. (as), Peeters, Petra H., Perez-Cornago, Aurora, Wareham, Nicholas J., Khaw, Kay-Thee, Freisling, Heinz, Cross, Amanda J., Riboli, Elio, and Scalbert, Augustin
Abstract: Flavonoids have been shown to inhibit colon cancer cell proliferation in vitro and protect against colorectal carcinogenesis in animal models. However, epidemiological evidence on the potential role of flavonoid intake in colorectal cancer (CRC) development remains sparse and inconsistent. We evaluated the association between dietary intakes of total flavonoids and their subclasses and risk of development of CRC, within the European Prospective Investigation into Cancer and Nutrition (EPIC) study. A cohort of 477,312 adult men and women were recruited in 10 European countries. At baseline, dietary intakes of total flavonoids and individual subclasses were estimated using centre-specific validated dietary questionnaires and composition data from the Phenol-Explorer database. During an average of 11 years of follow-up, 4,517 new cases of primary CRC were identified, of which 2,869 were colon (proximal = 1,298 and distal = 1,266) and 1,648 rectal tumours. No association was found between total flavonoid intake and the risk of overall CRC (HR for comparison of extreme quintiles 1.05, 95% CI 0.93-1.18; p-trend = 0.58) or any CRC subtype. No association was also observed with any intake of individual flavonoid subclasses. Similar results were observed for flavonoid intake expressed as glycosides or aglycone equivalents. Intake of total flavonoids and flavonoid subclasses, as estimated from dietary questionnaires, did not show any association with risk of CRC development.
Published: 2017
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37. Dietary and lifestyle determinants of acrylamide and glycidamide hemoglobin adducts in non-smoking postmenopausal women from the EPIC cohort

Author: Obón-Santacana, Mireia, Lujan-Barroso, Leila, Freisling, Heinz, Cadeau, Claire, Fagherazzi, Guy, Boutron-Ruault, Marie-Christine, Kaaks, Rudolf, Fortner, Renée T, Boeing, Heiner, Ramón Quirós, J, Molina-Montes, Esther, Chamosa, Saioa, Castaño, José María Huerta, Ardanaz, Eva, Khaw, Kay-Tee, Wareham, Nick, Key, Tim, Trichopoulou, Antonia, Lagiou, Pagona, Naska, Androniki, Palli, Domenico, Grioni, Sara, Tumino, Rosario, Vineis, Paolo, De Magistris, Maria Santucci, Bueno-de-Mesquita, H B, Peeters, Petra H, Wennberg, Maria, Bergdahl, Ingvar A, Vesper, Hubert, Riboli, Elio, Duell, Eric J, Obón-Santacana, Mireia, Lujan-Barroso, Leila, Freisling, Heinz, Cadeau, Claire, Fagherazzi, Guy, Boutron-Ruault, Marie-Christine, Kaaks, Rudolf, Fortner, Renée T, Boeing, Heiner, Ramón Quirós, J, Molina-Montes, Esther, Chamosa, Saioa, Castaño, José María Huerta, Ardanaz, Eva, Khaw, Kay-Tee, Wareham, Nick, Key, Tim, Trichopoulou, Antonia, Lagiou, Pagona, Naska, Androniki, Palli, Domenico, Grioni, Sara, Tumino, Rosario, Vineis, Paolo, De Magistris, Maria Santucci, Bueno-de-Mesquita, H B, Peeters, Petra H, Wennberg, Maria, Bergdahl, Ingvar A, Vesper, Hubert, Riboli, Elio, and Duell, Eric J
Abstract: PURPOSE: Acrylamide was classified as 'probably carcinogenic' to humans in 1994 by the International Agency for Research on Cancer. In 2002, public health concern increased when acrylamide was identified in starchy, plant-based foods, processed at high temperatures. The purpose of this study was to identify which food groups and lifestyle variables were determinants of hemoglobin adduct concentrations of acrylamide (HbAA) and glycidamide (HbGA) in 801 non-smoking postmenopausal women from eight countries in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. METHODS: Biomarkers of internal exposure were measured in red blood cells (collected at baseline) by high-performance liquid chromatography/tandem mass spectrometry (HPLC/MS/MS) . In this cross-sectional analysis, four dependent variables were evaluated: HbAA, HbGA, sum of total adducts (HbAA + HbGA), and their ratio (HbGA/HbAA). Simple and multiple regression analyses were used to identify determinants of the four outcome variables. All dependent variables (except HbGA/HbAA) and all independent variables were log-transformed (log2) to improve normality. Median (25th-75th percentile) HbAA and HbGA adduct levels were 41.3 (32.8-53.1) pmol/g Hb and 34.2 (25.4-46.9) pmol/g Hb, respectively. RESULTS: The main food group determinants of HbAA, HbGA, and HbAA + HbGA were biscuits, crackers, and dry cakes. Alcohol intake and body mass index were identified as the principal determinants of HbGA/HbAA. The total percent variation in HbAA, HbGA, HbAA + HbGA, and HbGA/HbAA explained in this study was 30, 26, 29, and 13 %, respectively. CONCLUSIONS: Dietary and lifestyle factors explain a moderate proportion of acrylamide adduct variation in non-smoking postmenopausal women from the EPIC cohort.
Published: 2017
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38. Association between plasma phospholipid saturated fatty acids and metabolic markers of lipid, hepatic, inflammation and glycaemic pathways in eight European countries: A cross-sectional analysis in the EPIC-InterAct study

Author: UMC Utrecht, Cardiovasculaire Epi Team 1, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Cardiovasculaire Epidemiologie, Zheng, Ju-Sheng, Sharp, Stephen J., Imamura, Fumiaki, Koulman, Albert, Schulze, Matthias B., Ye, Zheng, Griffin, Jules, Guevara, Marcela, Huerta, José María, Kröger, Janine, Sluijs, Ivonne, Agudo, Antonio, Barricarte, Aurelio, Boeing, Heiner, Colorado-Yohar, Sandra M, Dow, Courtney, Dorronsoro, Miren, Dinesen, Pia T, Fagherazzi, Guy, Franks, Paul W., Feskens, Edith J. M., Kühn, Tilman, Katzke, Verena Andrea, Key, Timothy J., Khaw, Kay Tee, de Magistris, Maria Santucci, Mancini, Francesca Romana, Molina-Portillo, Elena, Nilsson, Peter M., Olsen, Anja, Overvad, Kim, Palli, Domenico, Quirós, Jose Ramón, Rolandsson, Olov, Ricceri, Fulvio, Spijkerman, Annemieke M. W., Slimani, Nadia, Tagliabue, Giovanna, Tjonneland, Anne, Tumino, Rosario, van der Schouw, Yvonne T., Langenberg, Claudia, Riboli, Elio, Forouhi, Nita G., Wareham, Nicholas J., UMC Utrecht, Cardiovasculaire Epi Team 1, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Cardiovasculaire Epidemiologie, Zheng, Ju-Sheng, Sharp, Stephen J., Imamura, Fumiaki, Koulman, Albert, Schulze, Matthias B., Ye, Zheng, Griffin, Jules, Guevara, Marcela, Huerta, José María, Kröger, Janine, Sluijs, Ivonne, Agudo, Antonio, Barricarte, Aurelio, Boeing, Heiner, Colorado-Yohar, Sandra M, Dow, Courtney, Dorronsoro, Miren, Dinesen, Pia T, Fagherazzi, Guy, Franks, Paul W., Feskens, Edith J. M., Kühn, Tilman, Katzke, Verena Andrea, Key, Timothy J., Khaw, Kay Tee, de Magistris, Maria Santucci, Mancini, Francesca Romana, Molina-Portillo, Elena, Nilsson, Peter M., Olsen, Anja, Overvad, Kim, Palli, Domenico, Quirós, Jose Ramón, Rolandsson, Olov, Ricceri, Fulvio, Spijkerman, Annemieke M. W., Slimani, Nadia, Tagliabue, Giovanna, Tjonneland, Anne, Tumino, Rosario, van der Schouw, Yvonne T., Langenberg, Claudia, Riboli, Elio, Forouhi, Nita G., and Wareham, Nicholas J.
Published: 2017

39. Dietary and lifestyle determinants of acrylamide and glycidamide hemoglobin adducts in non-smoking postmenopausal women from the EPIC cohort

Author: Infection & Immunity, Cancer, Epi Kanker Team 1, JC onderzoeksprogramma Kanker, Obón-Santacana, Mireia, Lujan-Barroso, Leila, Freisling, Heinz, Cadeau, Claire, Fagherazzi, Guy, Boutron-Ruault, Marie Christine, Kaaks, Rudolf, Fortner, Renée T., Boeing, Heiner, Ramón Quirós, J., Molina-Montes, Esther, Chamosa, Saioa, Castaño, José María Huerta, Ardanaz, Eva, Khaw, Kay Tee, Wareham, Nick, Key, Tim, Trichopoulou, Antonia, Lagiou, Pagona, Naska, Androniki, Palli, Domenico, Grioni, Sara, Tumino, Rosario, Vineis, Paolo, de Magistris, Maria Santucci, Bueno-de-Mesquita, H. B., Peeters, Petra H., Wennberg, Maria, Bergdahl, Ingvar A., Vesper, Hubert, Riboli, Elio, Duell, Eric J., Infection & Immunity, Cancer, Epi Kanker Team 1, JC onderzoeksprogramma Kanker, Obón-Santacana, Mireia, Lujan-Barroso, Leila, Freisling, Heinz, Cadeau, Claire, Fagherazzi, Guy, Boutron-Ruault, Marie Christine, Kaaks, Rudolf, Fortner, Renée T., Boeing, Heiner, Ramón Quirós, J., Molina-Montes, Esther, Chamosa, Saioa, Castaño, José María Huerta, Ardanaz, Eva, Khaw, Kay Tee, Wareham, Nick, Key, Tim, Trichopoulou, Antonia, Lagiou, Pagona, Naska, Androniki, Palli, Domenico, Grioni, Sara, Tumino, Rosario, Vineis, Paolo, de Magistris, Maria Santucci, Bueno-de-Mesquita, H. B., Peeters, Petra H., Wennberg, Maria, Bergdahl, Ingvar A., Vesper, Hubert, Riboli, Elio, and Duell, Eric J.
Published: 2017

40. Main nutrient patterns are associated with prospective weight change in adults from 10 European countries

Author: Freisling, Heinz Pisa, Pedro T. Ferrari, Pietro Byrnes, Graham Moskal, Aurelie Dahm, Christina C. Vergnaud, Anne-Claire Boutron-Ruault, Marie-Christine Fagherazzi, Guy and Cadeau, Claire Kuehn, Tilman Neamat-Allah, Jasmine Buijsse, Brian Boeing, Heiner Halkjaer, Jytte Tjonneland, Anne and Hansen, Camilla P. Ramon Quiros, J. Travier, Noemie and Molina-Montes, Esther Amiano, Pilar Huerta, Jose M. and Barricarte, Aurelio Khaw, Kay-Tee Wareham, Nicholas Key, Tim J. Romaguera, Dora Lu, Yunxia Lassale, Camille M. Naska, Androniki Orfanos, Philippos Trichopoulou, Antonia Masala, Giovanna Pala, Valeria Berrino, Franco Tumino, Rosario and Ricceri, Fulvio de Magistris, Maria Santucci Bueno-de-Mesquita, H. Bas Ocke, Marga C. Sonestedt, Emily Ericson, Ulrika and Johansson, Mattias Skeie, Guri Weiderpass, Elisabete and Braaten, Tonje Peeters, Petra H. M. Slimani, Nadia
Abstract: Various food patterns have been associated with weight change in adults, but it is unknown which combinations of nutrients may account for such observations. We investigated associations between main nutrient patterns and prospective weight change in adults. This study includes 235,880 participants, 25-70 years old, recruited between 1992 and 2000 in 10 European countries. Intakes of 23 nutrients were estimated from country-specific validated dietary questionnaires using the harmonized EPIC Nutrient DataBase. Four nutrient patterns, explaining 67 % of the total variance of nutrient intakes, were previously identified from principal component analysis. Body weight was measured at recruitment and self-reported 5 years later. The relationship between nutrient patterns and annual weight change was examined separately for men and women using linear mixed models with random effect according to center controlling for confounders. Mean weight gain was 460 g/year (SD 950) and 420 g/year (SD 940) for men and women, respectively. The annual differences in weight gain per one SD increase in the pattern scores were as follows: principal component (PC) 1, characterized by nutrients from plant food sources, was inversely associated with weight gain in men (-22 g/year; 95 % CI -33 to -10) and women (-18 g/year; 95 % CI -26 to -11). In contrast, PC4, characterized by protein, vitamin B2, phosphorus, and calcium, was associated with a weight gain of +41 g/year (95 % CI +2 to +80) and +88 g/year (95 % CI +36 to +140) in men and women, respectively. Associations with PC2, a pattern driven by many micro-nutrients, and with PC3, a pattern driven by vitamin D, were less consistent and/or non-significant. We identified two main nutrient patterns that are associated with moderate but significant long-term differences in weight gain in adults.
Published: 2016

41. A treelet transform analysis to relate nutrient patterns to the risk of hormonal receptor-defined breast cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC)

Author: Assi, Nada Moskal, Aurelie Slimani, Nadia Viallon, Vivian and Chajes, Veronique Freisling, Heinz Monni, Stefano and Knueppel, Sven Foerster, Jana Weiderpass, Elisabete and Lujan-Barroso, Leila Amiano, Pilar Ardanaz, Eva and Molina-Montes, Esther Salmeron, Diego Ramon Quiros, Jose and Olsen, Anja Tjonneland, Anne Dahm, Christina C. Overvad, Kim and Dossus, Laure Fournier, Agnes Baglietto, Laura Fortner, Renee Turzanski Kaaks, Rudolf Trichopoulou, Antonia Bamia, Christina Orfanos, Philippos De Magistris, Maria Santucci and Masala, Giovanna Agnoli, Claudia Ricceri, Fulvio Tumino, Rosario de Mesquita, H. Bas Bueno Bakker, Marije F. Peeters, Petra H. M. Skeie, Guri Braaten, Tonje Winkvist, Anna and Johansson, Ingegerd Khaw, Kay-Tee Wareham, Nicholas J. Key, Tim Travis, Ruth Schmidt, Julie A. Merritt, Melissa A. and Riboli, Elio Romieu, Isabelle Ferrari, Pietro
Abstract: Objective Pattern analysis has emerged as a tool to depict the role of multiple nutrients/foods in relation to health outcomes. The present study aimed at extracting nutrient patterns with respect to breast cancer (BC) aetiology. Design Nutrient patterns were derived with treelet transform (TT) and related to BC risk. TT was applied to twenty-three log-transformed nutrient densities from dietary questionnaires. Hazard ratios (HR) and 95 % confidence intervals computed using Cox proportional hazards models quantified the association between quintiles of nutrient pattern scores and risk of overall BC, and by hormonal receptor and menopausal status. Principal component analysis was applied for comparison. Setting The European Prospective Investigation into Cancer and Nutrition (EPIC). Subjects Women (n 334 850) from the EPIC study. Results The first TT component (TC1) highlighted a pattern rich in nutrients found in animal foods loading on cholesterol, protein, retinol, vitamins B-12 and D, while the second TT component (TC2) reflected a diet rich in -carotene, riboflavin, thiamin, vitamins C and B-6, fibre, Fe, Ca, K, Mg, P and folate. While TC1 was not associated with BC risk, TC2 was inversely associated with BC risk overall (HRQ5 v. Q1=089, 95 % CI 083, 095, P-trend
Published: 2016

42. Association between plasma phospholipid saturated fatty acids and metabolic markers of lipid, hepatic, inflammation and glycaemic pathways in eight European countries: a cross-sectional analysis in the EPIC-InterAct study

Author: Zheng, Ju-Sheng, primary, Sharp, Stephen J., additional, Imamura, Fumiaki, additional, Koulman, Albert, additional, Schulze, Matthias B., additional, Ye, Zheng, additional, Griffin, Jules, additional, Guevara, Marcela, additional, Huerta, José María, additional, Kröger, Janine, additional, Sluijs, Ivonne, additional, Agudo, Antonio, additional, Barricarte, Aurelio, additional, Boeing, Heiner, additional, Colorado-Yohar, Sandra, additional, Dow, Courtney, additional, Dorronsoro, Miren, additional, Dinesen, Pia T., additional, Fagherazzi, Guy, additional, Franks, Paul W., additional, Feskens, Edith J. M., additional, Kühn, Tilman, additional, Katzke, Verena Andrea, additional, Key, Timothy J., additional, Khaw, Kay-Tee, additional, de Magistris, Maria Santucci, additional, Mancini, Francesca Romana, additional, Molina-Portillo, Elena, additional, Nilsson, Peter M., additional, Olsen, Anja, additional, Overvad, Kim, additional, Palli, Domenico, additional, Quirós, Jose Ramón, additional, Rolandsson, Olov, additional, Ricceri, Fulvio, additional, Spijkerman, Annemieke M. W., additional, Slimani, Nadia, additional, Tagliabue, Giovanna, additional, Tjonneland, Anne, additional, Tumino, Rosario, additional, van der Schouw, Yvonne T., additional, Langenberg, Claudia, additional, Riboli, Elio, additional, Forouhi, Nita G., additional, and Wareham, Nicholas J., additional
Published: 2017
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43. The Association between Glyceraldehyde-Derived Advanced Glycation End-Products and Colorectal Cancer Risk

Author: Kong, So Yeon Takeuchi, Masayoshi Hyogo, Hideyuki and McKeown-Eyssen, Gail Yamagishi, Sho-Ichi Chayama, Kazuaki and O'Brien, Peter J. Ferrari, Pietro Overvad, Kim Olsen, Anja and Tjonneland, Anne Boutron-Ruault, Marie-Christine Bastide, Nadia Carbonnel, Franck Kuehn, Tilman Kaaks, Rudolf and Boeing, Heiner Aleksandrova, Krasimira Trichopoulou, Antonia and Lagiou, Pagona Vasilopoulou, Effie Masala, Giovanna Pala, Valeria De Magistris, Maria Santucci Tumino, Rosario and Naccarati, Alessio Bueno-De-Mesquita, H. B. Peeters, Petra H. and Weiderpass, Elisabete Quiros, J. Ramon Jakszyn, Paula and Sanchez, Maria-Jose Dorronsoro, Miren Gavrila, Diana and Ardanaz, Eva Rutegard, Martin Nystroem, Hanna Wareham, Nicholas J. Khaw, Kay-Tee Bradbury, Kathryn E. Romieu, Isabelle Freisling, Heinz Stavropoulou, Faidra Gunter, Marc J. Cross, Amanda J. Riboli, Elio Jenab, Mazda Bruce, W. Robert
Abstract: Background: A large proportion of colorectal cancers are thought to be associated with unhealthy dietary and lifestyle exposures, particularly energy excess, obesity, hyperinsulinemia, and hyperglycemia. It has been suggested that these processes stimulate the production of toxic reactive carbonyls from sugars such as glyceraldehyde. Glyceraldehyde contributes to the production of a group of compounds known as glyceraldehyde-derived advanced glycation end-products (glycer-AGEs), which may promote colorectal cancer through their proinflammatory and pro-oxidative properties. The objective of this study nested within a prospective cohort was to explore the association of circulating glycer-AGEs with risk of colorectal cancer. Methods: A total of 1,055 colorectal cancer cases (colon n = 659; rectal n = 396) were matchced (1: 1) to control subjects. Circulating glycer-AGEs were measured by a competitive ELISA. Multivariable conditional logistic regression models were used to calculate ORs and 95% confidence intervals (95% CI), adjusting for potential confounding factors, including smoking, alcohol, physical activity, body mass index, and diabetes status. Results: Elevated glycer-AGEs levels were not associated with colorectal cancer risk (highest vs. lowest quartile, 1.10; 95% CI, 0.82-1.49). Subgroup analyses showed possible divergence by anatomical subsites (OR for colon cancer, 0.83; 95% CI, 0.571.22; OR for rectal cancer, 1.90; 95% CI, 1.14-3.19; Pheterogeneity = 0.14). Conclusions: In this prospective study, circulating glycer-AGEs were not associated with risk of colon cancer, but showed a positive association with the risk of rectal cancer. Impact: Further research is needed to clarify the role of toxic products of carbohydrate metabolism and energy excess in colorectal cancer development. (C) 2015 AACR.
Published: 2015

44. Subtypes of fruit and vegetables, variety in consumption and risk of colon and rectal cancer in the European Prospective Investigation into Cancer and Nutrition

Author: Leenders, Max Siersema, Peter D. Overvad, Kim Tjonneland, Anne Olsen, Anja Boutron-Ruault, Marie-Christine Bastide, Nadia Fagherazzi, Guy Katzke, Verena Kuehn, Tilman and Boeing, Heiner Aleksandrova, Krasimira Trichopoulou, Antonia and Lagiou, Pagona Klinaki, Eleni Masala, Giovanna Grioni, Sara and De Magistris, Maria Santucci Tumino, Rosario Ricceri, Fulvio and Peeters, Petra H. M. Lund, Eiliv Skeie, Guri Weiderpass, Elisabete Ramon Quiros, J. Agudo, Antonio Sanchez, Maria-Jose Dorronsoro, Miren Navarro, Carmen Ardanaz, Eva and Ohlsson, Bodil Jirstroem, Karin Van Guelpen, Bethany and Wennberg, Maria Khaw, Kay-Tee Wareham, Nick Key, Timothy J. and Romieu, Isabelle Huybrechts, Inge Cross, Amanda J. and Murphy, Neil Riboli, Elio Bueno-de-Mesquita, H. B(As)
Abstract: Previously, a lower risk of colorectal cancer was observed with fruit and vegetable consumption in the European Prospective Investigation into Cancer and Nutrition within a follow-up period of 9 years which was not fully supported by a recent meta-analysis. Therefore, we were interested in the relation with extended follow-up, also focusing on single subtypes and a variety of intake of fruit and vegetables. Fruit and vegetable consumption was assessed at baseline. After an average of 13 years of follow-up, 3,370 participants were diagnosed with colon or rectal cancer. Diet diversity scores were constructed to quantify variety in fruit and vegetable consumption. A lower risk of colon cancer was observed with higher self-reported consumption of fruit and vegetable combined (HR Q4 vs. Q1 0.87, 95% CI 0.75-1.01, p for trend 0.02), but no consistent association was observed for separate consumption of fruits and vegetables. No associations with risk of rectal cancer were observed. The few observed associations for some fruit and vegetable subtypes with colon cancer risk may have been due to chance. Variety in consumption of fruits and vegetables was not associated with a lower risk of colon or rectal cancer. Although a lower risk of colon cancer is suggested with high consumption of fruit and vegetables, this study does not support a clear inverse association between fruit and vegetable consumption and colon or rectal cancer beyond a follow-up of more than 10 years. Attenuation of the risk estimates from dietary changes over time cannot be excluded, but appears unlikely.
Published: 2015

45. Main nutrient patterns and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition study

Author: Moskal, Aurelie, Freisling, Heinz, Byrnes, Graham, Assi, Nada, Fahey, Michael T., Jenab, Mazda, Ferrari, Pietro, Tjonneland, Anne, Petersen, Kristina E. N., Dahm, Christina C., Plambeck Hansen, Camilla, Affret, Aurelie, Boutron-Ruault, Marie-Christine, Cadeau, Claire, Kuhn, Tilman, Katzke, Verena, Iqbal, Khalid, Boeing, Heiner, Trichopoulou, Antonia, Bamia, Christina, Naska, Androniki, Masala, Giovanna, de Magistris, Maria Santucci, Sieri, Sabina, Tumino, Rosario, Sacerdote, Carlotta, Peeters, Petra H., Bueno-De-Mesquita, Bas H., Engeset, Dagrun, Licaj, Idlir, Skeie, Guri, Ardanaz, Eva, Buckland, Genevieve, Huerta Castano, Jose M., Quiros, Jose R., Amiano, Pilar, Molina-Portillo, Elena, Winkvist, Anna, Myte, Robin, Ericson, Ulrika, Sonestedt, Emily, Perez-Cornago, Aurora, Wareham, Nick, Khaw, Kay-Tee, Huybrechts, Inge, Tsilidis, Konstantinos K., Ward, Heather, Gunter, Marc J., Slimani, Nadia, Moskal, Aurelie, Freisling, Heinz, Byrnes, Graham, Assi, Nada, Fahey, Michael T., Jenab, Mazda, Ferrari, Pietro, Tjonneland, Anne, Petersen, Kristina E. N., Dahm, Christina C., Plambeck Hansen, Camilla, Affret, Aurelie, Boutron-Ruault, Marie-Christine, Cadeau, Claire, Kuhn, Tilman, Katzke, Verena, Iqbal, Khalid, Boeing, Heiner, Trichopoulou, Antonia, Bamia, Christina, Naska, Androniki, Masala, Giovanna, de Magistris, Maria Santucci, Sieri, Sabina, Tumino, Rosario, Sacerdote, Carlotta, Peeters, Petra H., Bueno-De-Mesquita, Bas H., Engeset, Dagrun, Licaj, Idlir, Skeie, Guri, Ardanaz, Eva, Buckland, Genevieve, Huerta Castano, Jose M., Quiros, Jose R., Amiano, Pilar, Molina-Portillo, Elena, Winkvist, Anna, Myte, Robin, Ericson, Ulrika, Sonestedt, Emily, Perez-Cornago, Aurora, Wareham, Nick, Khaw, Kay-Tee, Huybrechts, Inge, Tsilidis, Konstantinos K., Ward, Heather, Gunter, Marc J., and Slimani, Nadia
Abstract: Background: Much of the current literature on diet-colorectal cancer (CRC) associations focused on studies of single foods/nutrients, whereas less is known about nutrient patterns. We investigated the association between major nutrient patterns and CRC risk in participants of the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Methods: Among 477 312 participants, intakes of 23 nutrients were estimated from validated dietary questionnaires. Using results from a previous principal component (PC) analysis, four major nutrient patterns were identified. Hazard ratios (HRs) and 95% confidence intervals (CIs) were computed for the association of each of the four patterns and CRC incidence using multivariate Cox proportional hazards models with adjustment for established CRC risk factors. Results: During an average of 11 years of follow-up, 4517 incident cases of CRC were documented. A nutrient pattern characterised by high intakes of vitamins and minerals was inversely associated with CRC (HR per 1 s.d. = 0.94, 95% CI: 0.92-0.98) as was a pattern characterised by total protein, riboflavin, phosphorus and calcium (HR (1 s.d.) = 0.96, 95% CI: 0.93-0.99). The remaining two patterns were not significantly associated with CRC risk. Conclusions: Analysing nutrient patterns may improve our understanding of how groups of nutrients relate to CRC.
Published: 2016
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46. A treelet transform analysis to relate nutrient patterns to the risk of hormonal receptor-defined breast cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC)

Author: Assi, Nada, Moskal, Aurelie, Slimani, Nadia, Viallon, Vivian, Chajes, Veronique, Freisling, Heinz, Monni, Stefano, Knueppel, Sven, Foerster, Jana, Weiderpass, Elisabete, Lujan-Barroso, Leila, Amiano, Pilar, Ardanaz, Eva, Molina-Montes, Esther, Salmeron, Diego, Ramon Quiros, Jose, Olsen, Anja, Tjonneland, Anne, Dahm, Christina C., Overvad, Kim, Dossus, Laure, Fournier, Agnes, Baglietto, Laura, Fortner, Renee Turzanski, Kaaks, Rudolf, Trichopoulou, Antonia, Bamia, Christina, Orfanos, Philippos, De Magistris, Maria Santucci, Masala, Giovanna, Agnoli, Claudia, Ricceri, Fulvio, Tumino, Rosario, de Mesquita, H. Bas Bueno, Bakker, Marije F., Peeters, Petra H. M., Skeie, Guri, Braaten, Tonje, Winkvist, Anna, Johansson, Ingegerd, Khaw, Kay-Tee, Wareham, Nicholas J., Key, Tim, Travis, Ruth, Schmidt, Julie A., Merritt, Melissa A., Riboli, Elio, Romieu, Isabelle, Ferrari, Pietro, Assi, Nada, Moskal, Aurelie, Slimani, Nadia, Viallon, Vivian, Chajes, Veronique, Freisling, Heinz, Monni, Stefano, Knueppel, Sven, Foerster, Jana, Weiderpass, Elisabete, Lujan-Barroso, Leila, Amiano, Pilar, Ardanaz, Eva, Molina-Montes, Esther, Salmeron, Diego, Ramon Quiros, Jose, Olsen, Anja, Tjonneland, Anne, Dahm, Christina C., Overvad, Kim, Dossus, Laure, Fournier, Agnes, Baglietto, Laura, Fortner, Renee Turzanski, Kaaks, Rudolf, Trichopoulou, Antonia, Bamia, Christina, Orfanos, Philippos, De Magistris, Maria Santucci, Masala, Giovanna, Agnoli, Claudia, Ricceri, Fulvio, Tumino, Rosario, de Mesquita, H. Bas Bueno, Bakker, Marije F., Peeters, Petra H. M., Skeie, Guri, Braaten, Tonje, Winkvist, Anna, Johansson, Ingegerd, Khaw, Kay-Tee, Wareham, Nicholas J., Key, Tim, Travis, Ruth, Schmidt, Julie A., Merritt, Melissa A., Riboli, Elio, Romieu, Isabelle, and Ferrari, Pietro
Abstract: Objective Pattern analysis has emerged as a tool to depict the role of multiple nutrients/foods in relation to health outcomes. The present study aimed at extracting nutrient patterns with respect to breast cancer (BC) aetiology. Design Nutrient patterns were derived with treelet transform (TT) and related to BC risk. TT was applied to twenty-three log-transformed nutrient densities from dietary questionnaires. Hazard ratios (HR) and 95 % confidence intervals computed using Cox proportional hazards models quantified the association between quintiles of nutrient pattern scores and risk of overall BC, and by hormonal receptor and menopausal status. Principal component analysis was applied for comparison. Setting The European Prospective Investigation into Cancer and Nutrition (EPIC). Subjects Women (n 334 850) from the EPIC study. Results The first TT component (TC1) highlighted a pattern rich in nutrients found in animal foods loading on cholesterol, protein, retinol, vitamins B-12 and D, while the second TT component (TC2) reflected a diet rich in -carotene, riboflavin, thiamin, vitamins C and B-6, fibre, Fe, Ca, K, Mg, P and folate. While TC1 was not associated with BC risk, TC2 was inversely associated with BC risk overall (HRQ5 v. Q1=089, 95 % CI 083, 095, P-trend<001) and showed a significantly lower risk in oestrogen receptor-positive (HRQ5 v. Q1=089, 95 % CI 081, 098, P-trend=002) and progesterone receptor-positive tumours (HRQ5 v. Q1=087, 95 % CI 077, 098, P-trend<001). Conclusions TT produces readily interpretable sparse components explaining similar amounts of variation as principal component analysis. Our results suggest that participants with a nutrient pattern high in micronutrients found in vegetables, fruits and cereals had a lower risk of BC.
Published: 2016
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47. Dietary polyphenol intake in Europe: the European Prospective Investigation into Cancer and Nutrition (EPIC) study

Author: Epi Kanker Team 1, JC onderzoeksprogramma Kanker, Cancer, MS MDL 1, Zamora-Ros, Raul, Knaze, Viktoria, Rothwell, Joseph A., Hemon, Bertrand, Moskal, Aurelie, Overvad, Kim, Tjonneland, Anne, Kyro, Cecilie, Fagherazzi, Guy, Boutron-Ruault, Marie-Christine, Touillaud, Marina, Katzke, Verena, Kuehn, Tilman, Boeing, Heiner, Foerster, Jana, Trichopoulou, Antonia, Valanou, Elissavet, Peppa, Eleni, Palli, Domenico, Agnoli, Claudia, Ricceri, Fulvio, Tumino, Rosario, de Magistris, Maria Santucci, Peeters, Petra H. M., Bueno-de-Mesquita, H. Bas, Engeset, Dagrun, Skeie, Guri, Hjartaker, Anette, Menendez, Virginia, Agudo, Antonio, Molina-Montes, Esther, Maria Huerta, Jose, Barricarte, Aurelio, Amiano, Pilar, Sonestedt, Emily, Nilsson, Lena Maria, Landberg, Rikard, Key, Timothy J., Khaw, Kay-Thee, Wareham, Nicholas J., Lu, Yunxia, Slimani, Nadia, Romieu, Isabelle, Riboli, Elio, Scalbert, Augustin, Epi Kanker Team 1, JC onderzoeksprogramma Kanker, Cancer, MS MDL 1, Zamora-Ros, Raul, Knaze, Viktoria, Rothwell, Joseph A., Hemon, Bertrand, Moskal, Aurelie, Overvad, Kim, Tjonneland, Anne, Kyro, Cecilie, Fagherazzi, Guy, Boutron-Ruault, Marie-Christine, Touillaud, Marina, Katzke, Verena, Kuehn, Tilman, Boeing, Heiner, Foerster, Jana, Trichopoulou, Antonia, Valanou, Elissavet, Peppa, Eleni, Palli, Domenico, Agnoli, Claudia, Ricceri, Fulvio, Tumino, Rosario, de Magistris, Maria Santucci, Peeters, Petra H. M., Bueno-de-Mesquita, H. Bas, Engeset, Dagrun, Skeie, Guri, Hjartaker, Anette, Menendez, Virginia, Agudo, Antonio, Molina-Montes, Esther, Maria Huerta, Jose, Barricarte, Aurelio, Amiano, Pilar, Sonestedt, Emily, Nilsson, Lena Maria, Landberg, Rikard, Key, Timothy J., Khaw, Kay-Thee, Wareham, Nicholas J., Lu, Yunxia, Slimani, Nadia, Romieu, Isabelle, Riboli, Elio, and Scalbert, Augustin
Published: 2016

48. Main nutrient patterns and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition study

Author: Epi Kanker Team 1, JC onderzoeksprogramma Kanker, Cancer, MS MDL 1, Moskal, Aurélie, Freisling, Heinz, Byrnes, Graham, Assi, Nada, Fahey, Michael T., Jenab, Mazda, Ferrari, Pietro, Tjønneland, Anne, Petersen, Kristina EN, Dahm, Christina C., Hansen, Camilla Plambeck, Affret, Aurélie, Boutron-Ruault, Marie Christine, Cadeau, Claire, Kühn, Tilman, Katzke, Verena, Iqbal, Khalid, Boeing, Heiner, Trichopoulou, Antonia, Bamia, Christina, Naska, Androniki, Masala, Giovanna, de Magistris, Maria Santucci, Sieri, Sabina, Tumino, Rosario, Sacerdote, Carlotta, Peeters, Petra H., Bueno-de-Mesquita, Bas H., Engeset, Dagrun, Licaj, Idlir, Skeie, Guri, Ardanaz, Eva, Buckland, Genevieve, Castaño, José M Huerta, Quirós, José R., Amiano, Pilar, Molina-Portillo, Elena, Winkvist, Anna, Myte, Robin, Ericson, Ulrika, Sonestedt, Emily, Perez-Cornago, Aurora, Wareham, Nick, Khaw, Kay Tee, Huybrechts, Inge, Tsilidis, Konstantinos K., Ward, Heather, Gunter, Marc J., Slimani, Nadia, Epi Kanker Team 1, JC onderzoeksprogramma Kanker, Cancer, MS MDL 1, Moskal, Aurélie, Freisling, Heinz, Byrnes, Graham, Assi, Nada, Fahey, Michael T., Jenab, Mazda, Ferrari, Pietro, Tjønneland, Anne, Petersen, Kristina EN, Dahm, Christina C., Hansen, Camilla Plambeck, Affret, Aurélie, Boutron-Ruault, Marie Christine, Cadeau, Claire, Kühn, Tilman, Katzke, Verena, Iqbal, Khalid, Boeing, Heiner, Trichopoulou, Antonia, Bamia, Christina, Naska, Androniki, Masala, Giovanna, de Magistris, Maria Santucci, Sieri, Sabina, Tumino, Rosario, Sacerdote, Carlotta, Peeters, Petra H., Bueno-de-Mesquita, Bas H., Engeset, Dagrun, Licaj, Idlir, Skeie, Guri, Ardanaz, Eva, Buckland, Genevieve, Castaño, José M Huerta, Quirós, José R., Amiano, Pilar, Molina-Portillo, Elena, Winkvist, Anna, Myte, Robin, Ericson, Ulrika, Sonestedt, Emily, Perez-Cornago, Aurora, Wareham, Nick, Khaw, Kay Tee, Huybrechts, Inge, Tsilidis, Konstantinos K., Ward, Heather, Gunter, Marc J., and Slimani, Nadia
Published: 2016

49. Main nutrient patterns are associated with prospective weight change in adults from 10 European countries

Author: Infection & Immunity, Cancer, Epi Kanker Team 1, JC onderzoeksprogramma Kanker, Freisling, Heinz, Pisa, Pedro T., Ferrari, Pietro, Byrnes, Graham, Moskal, Aurelie, Dahm, Christina C., Vergnaud, Anne Claire, Boutron-Ruault, Marie Christine, Fagherazzi, Guy, Cadeau, Claire, Kühn, Tilman, Neamat-Allah, Jasmine, Buijsse, Brian, Boeing, Heiner, Halkjær, Jytte, Tjonneland, Anne, Hansen, Camilla P., Quirós, J. Ramón, Travier, Noémie, Molina-Montes, Esther, Amiano, Pilar, Huerta, José M., Barricarte, Aurelio, Khaw, Kay Tee, Wareham, Nicholas, Key, Tim J., Romaguera, Dora, Lu, Yunxia, Lassale, Camille M., Naska, Androniki, Orfanos, Philippos, Trichopoulou, Antonia, Masala, Giovanna, Pala, Valeria, Berrino, Franco, Tumino, Rosario, Ricceri, Fulvio, de Magistris, Maria Santucci, Bueno-de-Mesquita, H. Bas, Ocké, Marga C., Sonestedt, Emily, Ericson, Ulrika, Johansson, Mattias, Skeie, Guri, Weiderpass, Elisabete, Braaten, Tonje, Peeters, Petra H M, Slimani, Nadia, Infection & Immunity, Cancer, Epi Kanker Team 1, JC onderzoeksprogramma Kanker, Freisling, Heinz, Pisa, Pedro T., Ferrari, Pietro, Byrnes, Graham, Moskal, Aurelie, Dahm, Christina C., Vergnaud, Anne Claire, Boutron-Ruault, Marie Christine, Fagherazzi, Guy, Cadeau, Claire, Kühn, Tilman, Neamat-Allah, Jasmine, Buijsse, Brian, Boeing, Heiner, Halkjær, Jytte, Tjonneland, Anne, Hansen, Camilla P., Quirós, J. Ramón, Travier, Noémie, Molina-Montes, Esther, Amiano, Pilar, Huerta, José M., Barricarte, Aurelio, Khaw, Kay Tee, Wareham, Nicholas, Key, Tim J., Romaguera, Dora, Lu, Yunxia, Lassale, Camille M., Naska, Androniki, Orfanos, Philippos, Trichopoulou, Antonia, Masala, Giovanna, Pala, Valeria, Berrino, Franco, Tumino, Rosario, Ricceri, Fulvio, de Magistris, Maria Santucci, Bueno-de-Mesquita, H. Bas, Ocké, Marga C., Sonestedt, Emily, Ericson, Ulrika, Johansson, Mattias, Skeie, Guri, Weiderpass, Elisabete, Braaten, Tonje, Peeters, Petra H M, and Slimani, Nadia
Published: 2016

50. A treelet transform analysis to relate nutrient patterns to the risk of hormonal receptor-defined breast cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC)

Author: Epi Kanker Team 1, JC onderzoeksprogramma Kanker, Cancer, MS MDL 1, Infection & Immunity, Epi Kanker Team A, Assi, Nada, Moskal, Aurelie, Slimani, Nadia, Viallon, Vivian, Chajes, Veronique, Freisling, Heinz, Monni, Stefano, Knueppel, Sven, Förster, Jana, Weiderpass, Elisabete, Lujan-Barroso, Leila, Amiano, Pilar, Ardanaz, Eva, Molina-Montes, Esther, Salmerón, Diego, Quirós, José Ramón, Olsen, Anja, Tjønneland, Anne, Dahm, Christina C., Overvad, Kim, Dossus, Laure, Fournier, Agnès, Baglietto, Laura, Fortner, Renee Turzanski, Kaaks, Rudolf, Trichopoulou, Antonia, Bamia, Christina, Orfanos, Philippos, De Magistris, Maria Santucci, Masala, Giovanna, Agnoli, Claudia, Ricceri, Fulvio, Tumino, Rosario, Bueno de Mesquita, H. Bas, Bakker, Marije F., Peeters, Petra H M, Skeie, Guri, Braaten, Tonje, Winkvist, Anna, Johansson, Ingegerd, Khaw, Kay Tee, Wareham, Nicholas J., Key, Tim, Travis, Ruth, Schmidt, Julie A., Merritt, Melissa A., Riboli, Elio, Romieu, Isabelle, Ferrari, Pietro, Epi Kanker Team 1, JC onderzoeksprogramma Kanker, Cancer, MS MDL 1, Infection & Immunity, Epi Kanker Team A, Assi, Nada, Moskal, Aurelie, Slimani, Nadia, Viallon, Vivian, Chajes, Veronique, Freisling, Heinz, Monni, Stefano, Knueppel, Sven, Förster, Jana, Weiderpass, Elisabete, Lujan-Barroso, Leila, Amiano, Pilar, Ardanaz, Eva, Molina-Montes, Esther, Salmerón, Diego, Quirós, José Ramón, Olsen, Anja, Tjønneland, Anne, Dahm, Christina C., Overvad, Kim, Dossus, Laure, Fournier, Agnès, Baglietto, Laura, Fortner, Renee Turzanski, Kaaks, Rudolf, Trichopoulou, Antonia, Bamia, Christina, Orfanos, Philippos, De Magistris, Maria Santucci, Masala, Giovanna, Agnoli, Claudia, Ricceri, Fulvio, Tumino, Rosario, Bueno de Mesquita, H. Bas, Bakker, Marije F., Peeters, Petra H M, Skeie, Guri, Braaten, Tonje, Winkvist, Anna, Johansson, Ingegerd, Khaw, Kay Tee, Wareham, Nicholas J., Key, Tim, Travis, Ruth, Schmidt, Julie A., Merritt, Melissa A., Riboli, Elio, Romieu, Isabelle, and Ferrari, Pietro
Published: 2016

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