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1. ABCC5, a gene that influences the anterior chamber depth, is associated with primary angle closure glaucoma

Author

Takanori Mizoguchi, Donald T.H. Tan, Renyi Wu, Hon-Tym Wong, Simon W. M. John, Shamira A. Perera, Michael A. Hauser, Tien Yin Wong, Azhany Yaakub, Yasuo Kurimoto, Jin-Xin Bei, Zheng Li, Eranga N. Vithana, Tina T. Wong, Mineo Ozaki, Serena M. L. Ting, Ningli Wang, Lingam Vijaya, Sancy Low, Chiea Chuen Khor, Ileana Soto, E-Shyong Tai, Hua Wang, Saleh A. Al-Obeidan, Hailin Meng, R. Rand Allingham, Govindasamy Kumaramanickavel, K. Saidas Nair, Ya Xing Wang, Kee Seng Chia, Daniel H. Su, Tran Nguyen Bich Chau, Seang-Mei Saw, Chunyan Qiao, Clement C Y Tham, Seng-Chee Loon, Victor H. K. Yong, Do Nhu Hon, Chi Pui Pang, Essam A. Osman, Shomi S. Bhattacharya, Paul T K Chew, Do Tan, Vedam L. Ramprasad, Ching-Lin Ho, Yik Ying Teo, Naushin Waseem, Liza-Sharmini Ahmad Tajudin, Cameron P. Simmons, Li Jia Chen, Hongyan Jia, Belinda K. Cornes, Alicia C. How, Monisha E. Nongpiur, Liang Xu, Khaled K. Abu-Amero, Bo Feng, Ronnie George, Yingfeng Zheng, Guangxian Tang, Jost B. Jonas, Ching-Yu Cheng, Yang Li, Nagaswamy Soumittra, Sujie Fan, Yi Xin Zeng, Mingzhi Zhang, Masako Kuroda, Balekudaru Shantha, Paul J. Foster, Tin Aung, and Raghavan Lavanya

Subjects
Cancer Research, medicine.medical_specialty, lcsh:QH426-470, Anterior Chamber, Population, Glaucoma, Locus (genetics), Genome-wide association study, ABCC5, Primary angle-closure glaucoma, Polymorphism, Single Nucleotide, Asian People, Risk Factors, Cornea, Ophthalmology, medicine, Genetics, Humans, 10. No inequality, education, Molecular Biology, Gene, Biology, Genetics (clinical), Ecology, Evolution, Behavior and Systematics, Clinical Genetics, education.field_of_study, biology, medicine.disease, lcsh:Genetics, medicine.anatomical_structure, biology.protein, Medicine, Multidrug Resistance-Associated Proteins, Glaucoma, Angle-Closure, Genome-Wide Association Study, Research Article
Abstract

Anterior chamber depth (ACD) is a key anatomical risk factor for primary angle closure glaucoma (PACG). We conducted a genome-wide association study (GWAS) on ACD to discover novel genes for PACG on a total of 5,308 population-based individuals of Asian descent. Genome-wide significant association was observed at a sequence variant within ABCC5 (rs1401999; per-allele effect size = −0.045 mm, P = 8.17×10−9). This locus was associated with an increase in risk of PACG in a separate case-control study of 4,276 PACG cases and 18,801 controls (per-allele OR = 1.13 [95% CI: 1.06–1.22], P = 0.00046). The association was strengthened when a sub-group of controls with open angles were included in the analysis (per-allele OR = 1.30, P = 7.45×10−9; 3,458 cases vs. 3,831 controls). Our findings suggest that the increase in PACG risk could in part be mediated by genetic sequence variants influencing anterior chamber dimensions., Author Summary The anterior chamber is the space within the eye which is bound by the cornea, and the anterior surfaces of the iris and lens. Anterior chamber depth (ACD) is the distance measured along the eye's optical axis, from the cornea to the lens surface. ACD is an important risk factor for primary angle closure glaucoma (PACG), a major cause of irreversible blindness worldwide, and in particular, individuals of Asian ethnicity. In order to identify the genes that underlie PACG susceptibility, we conducted a two-staged study. We first conducted a large scale genetic study on a total of 5,308 population-based individuals of Asian descent to identify the genetic variants that influence ACD. This was followed by testing for associations between the identified genetic variant and PACG in another independent collection of 4,276 PACG cases and 18,801 controls. We found that a genetic variant within ABCC5 was associated with an increased risk of having PACG. Our findings suggest that the increase in PACG risk could in part be mediated by genetic sequence variants that influence the anterior chamber dimensions of the eye.

Published
2017

2. Genome-wide association study identifies five new susceptibility loci for primary angle closure glaucoma

Author

Tina T. Wong, Yaan Fun Chong, Kathryn P. Burdon, Sancy Low, Ningli Wang, Tuan Anh Tran, Emma Rusmayani, Alexander C Day, Kei Tashiro, Tam Thi Luu, Aye Thi Han, Christine A. Kiire, Nay Lin Oo, Hiroshi Sakai, Ewa Kosior-Jarecka, Sripriya Sarangapani, Mimiwati Zahari, Widya Artini Wiyogo, Seng-Chee Loon, Rigo Daniel Reyes, Rrima Dada, Robert Ritch, E-Shyong Tai, Jin-Xin Bei, Ren-Yi Wu, Balekudaru Shantha, Leyla Al-Jasim, Giulia Consolandi, Ya Xing Wang, Saleh A. Al-Obeidan, Tomasz Zarnowski, Shazia Micheal, Maria Luisa Guevara-Fujita, Raquel Quino, Yuzhen Jiang, Monisha E. Nongpiur, Yik Y. Teo, Francesca Pasutto, Hailin Meng, Mani Baskaran, Shigeru Kinoshita, Sunee Chansangpetch, Clement C Y Tham, Eranga N. Vithana, Paul J. Foster, Greet J. Boland, Deepak P. Edward, Young Hoon Hwang, Daniel H. Su, Ricardo Fujita, Huan Nguyen Pham, Yong Ho Sohn, Mark Seielstad, Rengaraj Venkatesh, Paul Mitchell, Morio Ueno, Chaw Chaw Khaing, Thanh Thu Nguyen, Celso Tello, Anita S. Chan, Muhammad Imran Khan, Vernon Yong, Eileen Png, Takanori Mizoguchi, Nguyen Van Vinh Chau, Soo Hong Chew, Laura Dallorto, Chunyan Qiao, Donald T.H. Tan, Norlina Ramli, Mei Chin Lee, Rahat Husain, Kar Seng Sim, Sarah J. Dunstan, Kyu Hyung Park, Stephen A Vernon, Thi Nguyen, Rodolfo A. Perez-Grossmann, Jelinar Mohamed-Noor, Jeeyun Ahn, David Lozano-Giral, Tan Do, Yin Mon Aung, Prin Rojanapongpun, Naris Kitnarong, Martin L. Hibberd, Chan-Yun Kim, Mineo Ozaki, Manchima Makornwattana, Ronnie George, José Paulo Cabral de Vasconcellos, Huong T T Bui, Chona S Liao, Saw Htoo Set, Chi Pui Pang, Paul T K Chew, Aliza Jap, Naushin Waseem, Toshiaki Kubota, Tanuj Dada, Hyoung Won Bae, Tin Aung, Ricardo Y. Abe, Khin Thida Oo, Periasamy Sundaresan, Jose Maria Martinez, Visanee Tantisevi, Shomi S. Bhattacharya, Anneke I. den Hollander, Vira Wardhana Istiantoro, Rohit Shetty, Boonsong Wanichwecharungruang, Liang Xu, Seng Kheong Fang, Masakazu Nakano, E. Randy Craven, Richard P. Ebstein, Ching-Lin Ho, Arkasubhra Ghosh, Jeanne J. Ogle, Hongyan Jia, Muneeb A. Faiq, Yasuo Kurimoto, Michiko Yonahara, Richard Stead, Li Jia Chen, Satoko Nakano, Anavaj Sakuntabhai, Masako Kuroda, Thayanithi Sandragasu, Leonard W. Yip, Lerprat Mangkornkanokpong, Pancy O. S. Tam, Seang-Mei Saw, Ching-Yu Cheng, Saravanan Vijayan, Jia Nee Foo, M B Melo, Wing Lau Ho, Ahmad Tajudin Liza-Sharmini, Alex W. Hewitt, Mary Ann T Catacutan, Carlo Lavia, Curt Hartleben-Matkin, Hon-Tym Wong, Daniela Paoli, Srinivasan Kavitha, Su Nyunt Zaw, Soon Thye Lim, Owen Hee, Yee Yee Aung, Shuang Ru Goh, Chiea Chuen Khor, Maria Cecilia Aquino, Jonathan C.H. Chan, Buddha Basnyat, Zeiras Eka Djamal, Nhu Hon Do, Tuyet Bach Trinh, John H. Fingert, Z. Xie, Thi Lam Huong Dao, Urszula Lukasik, Bruno Batista de Souza, Khaled K. Abu-Amero, Yoko Ikeda, Guillermo Barreto Fong, Eng Hui Gan, Guangxian Tang, Sami Al-Shahwan, Tien Dat Tran, Jost B. Jonas, Xiao Yin Chen, Nagaswamy Soumittra, David Goh, Ramanjit Sihota, Xiao-Yu Ng, Ki Ho Park, Mona S Awadalla, Sujie Fan, Edgar U Leuenberger, Hlaing May Than, Jimmy S. M. Lai, Yi Xin Zeng, Shamira A. Perera, Bonnie Nga Kwan Choy, Jie Jin Wang, Roopam Duvesh, Antonio Maria Fea, Anita Manassakorn, Victor H. K. Yong, Abhilasha Karkey, John F Salmon, Kessara Pathanapitoon, Raheel Qamar, Juan Carlos Zenteno, Jin Wook Jeoung, Jovell Ian M Peregrino, Harm Snippe, Yaakub Azhany, Humaira Ayub, Vania Castro Tamanaja, Paolo Frezzotti, Tung S Hoan, Rajesh S. Kumar, Chelvin C A Sng, Jamie E Craig, Anuwat Prutthipongsit, Vital Paulino Costa, Subbiah. R. Krishnadas, Kuldeep Mohanty, Michael A. Hauser, Vi Huyen Doan, Irene R Felarca, Lingam Vijaya, Jennifer W. H. Shum, Farah Akhtar, R. Rand Allingham, Nuttamon Srisamran, Desmond Quek, Huaizhou Wang, Thipnapa Patthanathamrongkasem, Giulia Pignata, Suman S Thapa, Kazuhiko Mori, Jamil Miguel Neto, Tien Yin Wong, Boon-Ang Lim, Zheng Li, Genome Institute of Singapore (GIS), National University of Singapore (NUS), Vietnam National Institute of Ophthalmology (VNIO), Beijing Tongren Hospital, Kyoto University [Kyoto], Génétique fonctionnelle des Maladies infectieuses - Functional Genetics of Infectious Diseases, Centre National de la Recherche Scientifique (CNRS)-Institut Pasteur [Paris], This research is supported by the Singapore Ministry of Health's National Medical Research Council under its Translational and Clinical Research (TCR) Flagship Programme Grant Stratified Medicine for Primary Angle Closure Glaucoma (NMRC/TCR/008-SERI/2013) and the Singapore Translational Research (STaR) Investigator Award Singapore Angle Closure Glaucoma Program Characterization, Prevention, and Management (NMRC/STAR/0023/2014), as well as the Biomedical Research Council, Agency for Science, Technology and Research (A-STAR), Singapore. A.T.L.-S. gratefully acknowledges support from grants RUI 1001/PPSP/812101 and RUI 1001/PPSP/812152 from the Universiti Sains Malaysia. H.J., C.Q., and N. Wang acknowledge support from the Program of Beijing Scholars (2013), Leading Talents–High-Level Talents of the Health System of Beijing (2009-1-05), and the National Major Scientific and Technological Special Project for 'Significant New Drugs Development' (2011ZX09302-007-05), as well as Project of the National Natural Science Foundation of China (81570837) grants., Kyoto University, and Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Male, 0301 basic medicine, MESH: Gene Expression, Genotype, Population, Gene Expression, Glaucoma, Genome-wide association study, Biology, Primary angle-closure glaucoma, MESH: Genetic Loci, Cell Line, MESH: Genotype, 03 medical and health sciences, 0302 clinical medicine, Genetics, medicine, Humans, SNP, Genetic Predisposition to Disease, education, education.field_of_study, [SDV.GEN]Life Sciences [q-bio]/Genetics, MESH: Humans, MESH: Genetic Predisposition to Disease, Chromosome Mapping, Odds ratio, medicine.disease, MESH: Male, 3. Good health, MESH: Cell Line, 030104 developmental biology, Genetic Loci, MESH: Genome-Wide Association Study, 030221 ophthalmology & optometry, Susceptibility locus, MESH: Glaucoma, Angle-Closure, Female, Glaucoma, Angle-Closure, MESH: Chromosome Mapping, MESH: Female, Genome-Wide Association Study
Abstract

International audience; Primary angle closure glaucoma (PACG) is a major cause of blindness worldwide. We conducted a genome-wide association study (GWAS) followed by replication in a combined total of 10,503 PACG cases and 29,567 controls drawn from 24 countries across Asia, Australia, Europe, North America, and South America. We observed significant evidence of disease association at five new genetic loci upon meta-analysis of all patient collections. These loci are at EPDR1 rs3816415 (odds ratio (OR) = 1.24, P = 5.94 × 10(-15)), CHAT rs1258267 (OR = 1.22, P = 2.85 × 10(-16)), GLIS3 rs736893 (OR = 1.18, P = 1.43 × 10(-14)), FERMT2 rs7494379 (OR = 1.14, P = 3.43 × 10(-11)), and DPM2-FAM102A rs3739821 (OR = 1.15, P = 8.32 × 10(-12)). We also confirmed significant association at three previously described loci (P < 5 × 10(-8) for each sentinel SNP at PLEKHA7, COL11A1, and PCMTD1-ST18), providing new insights into the biology of PACG.

Published
2016

3. A common variant near TGFBR3 is associated with primary open angle glaucoma

Author

Zhenglin Yang, Tien Yin Wong, Zheng Li, Kei Tashiro, R. Rand Allingham, Julia E. Richards, Nobuo Fuse, Wee Yang Meah, Robert Ritch, Yik Ying Teo, Dan Milea, Takanori Mizoguchi, Puya Gharahkhani, David F. Garway-Heath, David Goh, Yoko Ikeda, Allison E. Ashley Koch, Wang Xu, Baskaran Mani, Ronnie George, Masakazu Nakano, Jessica N. Cooke Bailey, Janey L. Wiggs, Ying Lin, Yutao Liu, Xiao Yu Ng, Hong Zhang, Stuart MacGregor, Leon W. Herndon, Mei Chin Lee, Elaine Chua, Jost B. Jonas, Tran Nguyen Bich Chau, Balekudaru Shantha, Cameron P. Simmons, SR Krishnadas, Kazuhiko Mori, Ching-Lin Ho, Rupert R A Bourne, Augusto Azuara Blanco, Ching-Yu Cheng, Kathryn P. Burdon, Liza-Sharmini Ahmad Tajudin, Shamira A. Perera, Do Nhu Hon, Louis R. Pasquale, Monisha E. Nongpiur, Khaled K. Abu-Amero, Tin Aung, Rahat Husain, Anil Negi, Ningli Wang, Chukai Huang, Jinghong Sang, Mineo Ozaki, Sarangapani Sripriya, E-Shyong Tai, Saleh A. Al-Obeidan, Jong Chul Han, Chiea Chuen Khor, Jia Nee Foo, Mingzhi Zhang, David C Broadway, David A. Mackey, Ryuichi Sato, Songhomita Panda-Jonas, Prasanthi Namburi, Jamie E Craig, Merwyn Chew, Nihong Zhang, Christopher A. Girkin, Jae H. Kang, Blanche Lim, Anita S Y Chan, Yuhong Chen, Michael A. Hauser, Douglas E. Gaasterland, Chi Pui Pang, Daniel H. Su, Pascal Reynier, Azhany Yakub, Pratap Challa, Alex W. Hewitt, Bowen Zhao, Victor H. K. Yong, Saravanan Vijayan, Yi Xin Zeng, Jonathan L. Haines, Essam A. Osman, Pansy O.S. Tam, Lingam Vijaya, Xinghuai Sun, Aurelien Goncalves, Jianjun Liu, Morio Ueno, Sayoko E. Moroi, Shigeru Kinoshita, Liyun Jia, Kengo Yoshii, Seang-Mei Saw, Tina T. Wong, Yaan Fun Chong, Philomenadin Ferdinamarie Sharmila, Changwon Kee, Tan Do, Periasamy Sundaresan, Jin-Xin Bei, Eranga N. Vithana, Christopher Kai-shun Leung, Sohn Seongsoo, and Li Jia Chen

Subjects
Male, Open angle glaucoma, genetic structures, Genotype, Population, Glaucoma, Single-nucleotide polymorphism, Genome-wide association study, Biology, Polymorphism, Single Nucleotide, 03 medical and health sciences, 0302 clinical medicine, Genetics, medicine, SNP, Humans, education, Molecular Biology, Exome, Genetics (clinical), Alleles, 030304 developmental biology, Aged, Aged, 80 and over, 0303 health sciences, education.field_of_study, Association Studies Articles, Genetic Variation, General Medicine, Odds ratio, Middle Aged, medicine.disease, eye diseases, 3. Good health, 030221 ophthalmology & optometry, Female, Proteoglycans, sense organs, Receptors, Transforming Growth Factor beta, Glaucoma, Open-Angle
Abstract

Primary open angle glaucoma (POAG), a major cause of blindness worldwide, is a complex disease with a significant genetic contribution. We performed Exome Array (Illumina) analysis on 3504 POAG cases and 9746 controls with replication of the most significant findings in 9173 POAG cases and 26 780 controls across 18 collections of Asian, African and European descent. Apart from confirming strong evidence of association at CDKN2B-AS1 (rs2157719 [G], odds ratio [OR] = 0.71, P = 2.81 × 10(-33)), we observed one SNP showing significant association to POAG (CDC7-TGFBR3 rs1192415, ORG-allele = 1.13, Pmeta = 1.60 × 10(-8)). This particular SNP has previously been shown to be strongly associated with optic disc area and vertical cup-to-disc ratio, which are regarded as glaucoma-related quantitative traits. Our study now extends this by directly implicating it in POAG disease pathogenesis.

Published
2014

4. Efficacy of selective laser trabeculoplasty in primary angle-closure glaucoma: a randomized clinical trial

Author

Michael Belkin, Mani Baskaran, Hla Myint Htoon, Ching-Lin Ho, Donny V. Istiantoro, Tina T. Wong, Tin Aung, Daniel H. Su, David Goh, Monisha E. Nongpiur, Arun Narayanaswamy, Christopher Kai-Shun Leung, and Shamira A. Perera

Subjects
Male, medicine.medical_specialty, Intraocular pressure, genetic structures, medicine.medical_treatment, Glaucoma, Trabeculectomy, law.invention, Travoprost, Randomized controlled trial, law, Ophthalmology, medicine, Gonioscopy, Glaucoma surgery, Humans, Antihypertensive Agents, Intraocular Pressure, Aged, Retrospective Studies, Intention-to-treat analysis, medicine.diagnostic_test, business.industry, Cloprostenol, Middle Aged, medicine.disease, eye diseases, Surgery, Prostaglandin analog, Treatment Outcome, Elective Surgical Procedures, Female, sense organs, Laser Therapy, business, Glaucoma, Angle-Closure, medicine.drug, Follow-Up Studies
Abstract

Selective laser trabeculoplasty (SLT) should be explored as a therapeutic option in eyes with angle closure.To assess the intraocular pressure (IOP)-lowering efficacy of SLT in eyes with primary angle closure (PAC) and PAC glaucoma (PACG).Randomized clinical trial at tertiary eye care institutions of 100 patients diagnosed as having PAC or PAC glaucoma in which the angles had opened at least 180° (visible posterior trabecular meshwork on gonioscopy) after laser iridotomy. Recruitment and baseline were completed from June 2009 to April 2012 and 6-month follow-up was completed from December 2009 to November 2012.Eligible patients with a baseline IOP greater than 21 mm Hg were randomized to either SLT or prostaglandin analog (PGA; travoprost, 0.004%). The SLT was repeated if the IOP reduction was less than 20.0% from baseline at the 1- or 3-month follow-up visit.The primary outcome measure was the change in IOP from baseline to the final follow-up visit (at 6 months). The frequency of additional postoperative treatments and complications were secondary outcomes.Fifty patients (96 eyes) were randomized to SLT and 50 patients (99 eyes) to PGA medical therapy. At 6 months, 49 patients in the SLT group and 47 in the PGA group completed follow-up. Analysis was based on intent to treat. At 6 months, IOP decreased by 4.0 mm Hg (95% CI, 3.2-4.8) in the SLT group (P .001) and by 4.2 mm Hg (95% CI, 3.5-4.9) in the PGA group (P .001). There were no differences between the SLT and PGA groups in the absolute mean reduction of IOP (4.0 vs 4.2 mm Hg, respectively; P = .78) or in the percentage of reduction in IOP (16.9% vs 18.5%, respectively; P = .52). Complete success (IOP ≤21 mm Hg without medications) was achieved in 60.0% eyes of the SLT group, compared with 84.0% of eyes in the PGA group (P = .008). No patients required glaucoma surgery. Additional medications were required in 22.0% of patients in the SLT group compared with 8.0% in the PGA group (P = .05). One patient in the SLT group (2.0%) had a transient posttreatment IOP spike greater than 5 mm Hg. The mean endothelial cell count showed a significant decrease from baseline in the SLT arm (4.8% decrease; P = .001). No other events such as persistent uveitis or increase in peripheral anterior synechiae were noted in eyes that underwent SLT. Two patients in the PGA group exited owing to drug-related complications (1 patient with uveitis and 1 with allergic conjunctivitis).Eyes with PAC or PACG respond to SLT in the short term, but the overall long-term therapeutic effectiveness needs further evaluation.clinicaltrials.gov Identifier: NCT01004900.

Published
2014

5. Comparison of ocular response analyzer parameters in chinese subjects with primary angle-closure and primary open-angle glaucoma

Author

Anna C S Tan, Mani Baskaran, Tin Aung, Monisha E. Nongpiur, Arun Narayanaswamy, Daniel H. Su, Tien Yin Wong, and Hla Myint Htoon

Subjects
Male, Intraocular pressure, medicine.medical_specialty, China, genetic structures, Open angle glaucoma, Eye disease, Population, Glaucoma, Cornea, Tonometry, Ocular, Asian People, Ophthalmology, medicine, Humans, Prospective Studies, Prospective cohort study, education, Intraocular Pressure, Aged, education.field_of_study, business.industry, Middle Aged, medicine.disease, eye diseases, Confidence interval, Biomechanical Phenomena, medicine.anatomical_structure, Cross-Sectional Studies, Female, sense organs, business, Glaucoma, Angle-Closure, Glaucoma, Open-Angle
Abstract

OBJECTIVES: To evaluate corneal hysteresis (CH) and intraocular pressure (IOP) measured by the Ocular Response Analyzer in Chinese subjects with primary angle-closure glaucoma (PACG), assess their relationship with Goldmann applanation tonometry (GAT) measurements, and compare this with subjects with primary open-angle glaucoma (POAG) and normal controls. METHODS: In this prospective observational study, consecutive subjects with PACG and POAG without prior intraocular surgery were enrolled from glaucoma clinics. Normal subjects were recruited from an ongoing population-based study. One eye of each subject underwent standardized ocular examination and IOP measurement by GAT and the Ocular Response Analyzer. Corneal hysteresis and corneal-compensated IOP were compared between groups. RESULTS: Of the 443 subjects recruited, 131 had PACG, 162 had POAG, and 150 were normal. Corneal hysteresis was lower in PACG (9.1 mm Hg; 95% confidence interval [CI], 8.7 to 9.4 mm Hg) and POAG (9.5 mm Hg; 95% CI, 9.2 to 9.5 mm Hg) eyes compared with control eyes (10.4 mm Hg; 95% CI, 10.1 to 10.6 mm Hg; P

Published
2011

6. Relatos de experiencia, saber pedagógico y reconstrucción de la memoria escolar Statements of experience, pedagogical knowledge and reconstruction of the school memory

Author

Daniel H. Suárez

Subjects
Relatos de Experiencia, Saber Pedagógico, Memoria Escolar, Statements of Experience, Pedagogical Knowledge, School Memory, Education (General), L7-991
Abstract

El artículo explora las potencialidades teóricas, metodológicas y políticas de la documentación narrativa de experiencias pedagógicas como dispositivo de investigación-formación-acción entre docentes y modalidad de trabajo colaborativo orientado a la reconstrucción de la memoria pedagógica de la escuela y al cambio educativo. Para ello, propone una mirada pedagógica de las escuelas, los docentes y el currículum, vincula en términos teóricos la narrativa docente, la memoria pedagógica y el currículum en acción, presenta argumentos a favor del diseño de formas de documentación pedagógica alternativas a las dominantes, pondera los relatos de experiencias pedagógicas como otra manera de nombrar el mundo escolar, se interroga e identifica potencialidades críticas de la estrategia, pone en consideración una definición amplia de saber pedagógico e imagina algunas implicancias intelectuales y políticas de la difusión de estas modalidades alternativas de producción de saber pedagógico, formación entre pares e intervención política en el campo pedagógico.The article explores the methodological, theoretical and political potentialities of the narrative documentation of pedagogical experiences as an instrument of educational action research among teachers and as a modality of collaborative work orientated to the reconstruction of the pedagogical memory of the school and to the educational change. Thus, it proposes a pedagogical view of the schools, the teachers and the curriculum, connects in theoretical terms the teacher's narrative, the pedagogical memory and the curriculum in action, presents arguments in favor of the drawing of alternative forms of pedagogical documentation to the dominant ones, shows the statements of pedagogical experiences as another way of naming the school world, asks and identifies critical potentialities of strategy, puts in consideration a wide definition of pedagogical knowledge and imagines some intellectual and political implications of the diffusion of these alternative modalities to produce pedagogical knowledge, formation in pairs and political intervention in the pedagogic field.

Published
2011
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7. ABCC5, a gene that influences the anterior chamber depth, is associated with primary angle closure glaucoma.

Author

Monisha E Nongpiur, Chiea Chuen Khor, Hongyan Jia, Belinda K Cornes, Li-Jia Chen, Chunyan Qiao, K Saidas Nair, Ching-Yu Cheng, Liang Xu, Ronnie George, Do Tan, Khaled Abu-Amero, Shamira A Perera, Mineo Ozaki, Takanori Mizoguchi, Yasuo Kurimoto, Sancy Low, Liza-Sharmini A Tajudin, Ching-Lin Ho, Clement C Y Tham, Ileana Soto, Paul T K Chew, Hon-Tym Wong, Balekudaru Shantha, Masako Kuroda, Essam A Osman, Guangxian Tang, Sujie Fan, Hailin Meng, Hua Wang, Bo Feng, Victor H K Yong, Serena M L Ting, Yang Li, Ya-Xing Wang, Zheng Li, Raghavan Lavanya, Ren-Yi Wu, Ying-Feng Zheng, Daniel H Su, Seng-Chee Loon, Vernon K Y Yong, R Rand Allingham, Michael A Hauser, Nagaswamy Soumittra, Vedam L Ramprasad, Naushin Waseem, Azhany Yaakub, Kee-Seng Chia, Govindasamy Kumaramanickavel, Tina T Wong, Alicia C How, Tran Nguyen Bich Chau, Cameron P Simmons, Jin-Xin Bei, Yi-Xin Zeng, Shomi S Bhattacharya, Mingzhi Zhang, Donald T Tan, Yik-Ying Teo, Saleh A Al-Obeidan, Do Nhu Hon, E-Shyong Tai, Seang-Mei Saw, Paul J Foster, Lingam Vijaya, Jost B Jonas, Tien-Yin Wong, Simon W M John, Chi-Pui Pang, Eranga N Vithana, Ningli Wang, and Tin Aung

Subjects
Genetics, QH426-470
Abstract

Anterior chamber depth (ACD) is a key anatomical risk factor for primary angle closure glaucoma (PACG). We conducted a genome-wide association study (GWAS) on ACD to discover novel genes for PACG on a total of 5,308 population-based individuals of Asian descent. Genome-wide significant association was observed at a sequence variant within ABCC5 (rs1401999; per-allele effect size = -0.045 mm, P = 8.17 × 10(-9)). This locus was associated with an increase in risk of PACG in a separate case-control study of 4,276 PACG cases and 18,801 controls (per-allele OR = 1.13 [95% CI: 1.06-1.22], P = 0.00046). The association was strengthened when a sub-group of controls with open angles were included in the analysis (per-allele OR = 1.30, P = 7.45 × 10(-9); 3,458 cases vs. 3,831 controls). Our findings suggest that the increase in PACG risk could in part be mediated by genetic sequence variants influencing anterior chamber dimensions.

Published
2014
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