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2. Whole genomes from bacteria collected at diagnostic units around the world 2020

Author

Nag, Sidsel, Larsen, Gunhild, Szarvas, Judit, Birkedahl, Laura Elmlund Kohl, Gulyás, Gábor Máté, Ciok, Wojchiech Jakub, Lagermann, Timmie Mikkel, Tafaj, Silva, Bradbury, Susan, Collignon, Peter, Daley, Denise, Dougnon, Victorien, Fabiyi, Kafayath, Coulibaly, Boubacar, Dembélé, René, Nikiema, Georgette, Magloire, Natama, Ouindgueta, Isidore Juste, Hossain, Zenat Zebin, Begum, Anowara, Donchev, Deyan, Diggle, Mathew, Turnbull, LeeAnn, Lévesque, Simon, Berlinger, Livia, Sogaard, Kirstine Kobberoe, Guevara, Paula Diaz, Valderrama, Carolina Duarte, Maikanti, Panagiota, Amlerova, Jana, Drevinek, Pavel, Tkadlec, Jan, Dilas, Milica, Kaasch, Achim, Westh, Henrik Torkil, Bachtarzi, Mohamed Azzedine, Amhis, Wahiba, Salazar, Carolina Elisabeth Satán, Villacis, JoséEduardo, Lúzon, Mária Angeles Dominguez, Palau, Dámaris Berbel, Duployez, Claire, Paluche, Maxime, Asante-Sefa, Solomon, Moller, Mie, Ip, Margaret, Mareković, Ivana, Pál-Sonnevend, Agnes, Cocuzza, Clementiza Elvezia, Dambrauskiene, Asta, Macanze, Alexandre, Cossa, Anelsio, Mandomando, Inácio, Nwajiobi-Princewill, Philip, Okeke, Iruka N., Kehinde, Aderemi O., Adebiyi, Ini, Akintayo, Ifeoluwa, Popoola, Oluwafemi, Onipede, Anthony, Blomfeldt, Anita, Nyquist, Nora Elisabeth, Bocker, Kiri, Ussher, James, Ali, Amjad, Ullah, Nimat, Khan, Habibullah, Gustafson, Natalie Weiler, Jarrar, Ikhlas, Al-Hamad, Arif, Luvira, Viravarn, Paveenkittiporn, Wantana, Baran, Irmak, Mwansa, James C. L., Sikakwa, Linda, Yamba, Kaunda, Hendriksen, Rene Sjogren, and Aarestrup, Frank Moller

Published
2023
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3. Complete genome sequences of Cytobacillus sp., Domibacillus sp., Enterobacter sp., Neisseria sp., Pseudomonas sp., and Streptococcus sp. strains from human clinical infections collected at diagnostic units in 2020

Author

Szarvas, Judit, primary, Nag, Sidsel, additional, Otani, Saria, additional, Birkedahl, Laura Elmlund Kohl, additional, Møller, Frederik Duus, additional, Asante-Sefa, Solomon, additional, Daley, Denise, additional, Gustafson, Natalie Weiler, additional, Møller, Mie, additional, Onipede, Anthony, additional, Tafaj, Silva, additional, and Aarestrup, Frank M., additional

Published
2024
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4. Whole genome sequencing and molecular epidemiology of paediatric Staphylococcus aureus bacteraemia

Author

Campbell, Anita J., Mowlaboccus, Shakeel, Coombs, Geoffrey W., Daley, Denise A., Al Yazidi, Laila S., Phuong, Linny K., Leung, Clare, Best, Emma J., Webb, Rachel H., Voss, Lesley, Athan, Eugene, Britton, Philip N., Bryant, Penelope A., Butters, Coen T., Carapetis, Jonathan R., Ching, Natasha S., Francis, Joshua, Hung, Te-Yu, Nourse, Clare, Ojaimi, Samar, Tai, Alex, Vasilunas, Nan, McMullan, Brendan, Bowen, Asha C., and Blyth, Christopher C.

Published
2022
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9. A meta-analysis of genome-wide association studies for serum total IgE in diverse study populations

Author

Levin, Albert M, Mathias, Rasika A, Huang, Lili, Roth, Lindsey A, Daley, Denise, Myers, Rachel A, Himes, Blanca E, Romieu, Isabelle, Yang, Mao, Eng, Celeste, Park, Julie E, Zoratti, Karla, Gignoux, Christopher R, Torgerson, Dara G, Galanter, Joshua M, Huntsman, Scott, Nguyen, Elizabeth A, Becker, Allan B, Chan-Yeung, Moira, Kozyrskyj, Anita L, Kwok, Pui-Yan, Gilliland, Frank D, Gauderman, W James, Bleecker, Eugene R, Raby, Benjamin A, Meyers, Deborah A, London, Stephanie J, Martinez, Fernando D, Weiss, Scott T, Burchard, Esteban G, Nicolae, Dan L, Ober, Carole, Barnes, Kathleen C, and Williams, L Keoki

Subjects
Biomedical and Clinical Sciences, Immunology, Lung, Human Genome, Clinical Research, Genetics, Asthma, 2.1 Biological and endogenous factors, Aetiology, Inflammatory and immune system, Adolescent, Adult, Black or African American, Aged, Aged, 80 and over, Canada, Case-Control Studies, Child, Child, Preschool, Female, Genome-Wide Association Study, HLA-DQ beta-Chains, Hispanic or Latino, Humans, Immunoglobulin E, Male, Middle Aged, Polymorphism, Single Nucleotide, United States, White People, Meta-analysis, genome-wide association study, total IgE, race-ethnicity, continental population groups, Allergy
Abstract

BackgroundIgE is both a marker and mediator of allergic inflammation. Despite reported differences in serum total IgE levels by race-ethnicity, African American and Latino subjects have not been well represented in genetic studies of total IgE.ObjectiveWe sought to identify the genetic predictors of serum total IgE levels.MethodsWe used genome-wide association data from 4292 subjects (2469 African Americans, 1564 European Americans, and 259 Latinos) in the EVE Asthma Genetics Consortium. Tests for association were performed within each cohort by race-ethnic group (ie, African American, Latino, and European American) and asthma status. The resulting P values were meta-analyzed, accounting for sample size and direction of effect. Top single nucleotide polymorphism associations from the meta-analysis were reassessed in 6 additional cohorts comprising 5767 subjects.ResultsWe identified 10 unique regions in which the combined association statistic was associated with total serum IgE levels (P

Published
2013

11. Severe Disease Caused by Community-Associated MRSA ST398 Type V, Australia, 2017

Author

Coombs, Geoffrey W., Pang, Stanley, Daley, Denise A., Lee, Yung Thin, Abraham, Sam, and Leroi, Marcel

Subjects
Microbial drug resistance -- Genetic aspects, Staphylococcus aureus infections -- Genetic aspects -- Complications and side effects -- Drug therapy, Bacteremia -- Genetic aspects -- Development and progression -- Drug therapy, Genotypes -- Identification and classification -- Health aspects, Intelligence gathering, DNA sequencing, Genomics, Staphylococcus aureus, Hospitals, Infection, Drug resistance, Genomes, Livestock, Health
Abstract

The Australian Group on Antimicrobial Resistance (http://agargroup.org.au/) manages multiple national antimicrobial drug resistance surveillance programs, including the Australian Staphylococcus Sepsis Outcome Programme. This program involves 38 hospitals across Australia continuously [...]

Published
2019
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13. Molecular characterization of fosfomycin-resistant Escherichia coli urinary tract infection isolates from Australia

Author

Mowlaboccus, Shakeel, primary, Daley, Denise A., additional, Birdsall, Jacob, additional, Gottlieb, Thomas, additional, Merlino, John, additional, Nimmo, Graeme R., additional, George, Narelle, additional, Korman, Tony, additional, Streitberg, Richard, additional, Robson, Jenny, additional, Peachey, Georgia, additional, Collignon, Peter, additional, Bradbury, Susan, additional, Rogers, Benjamin A., additional, and Coombs, Geoffrey W., additional

Published
2021
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14. Genome-Wide Association Study Identification of Novel Loci Associated with Airway Responsiveness in Chronic Obstructive Pulmonary Disease

Author

Hansel, Nadia N., Paré, Peter D., Rafaels, Nicholas, Sin, Don D., Sandford, Andrew, Daley, Denise, Vergara, Candelaria, Huang, Lili, Elliott, Mark W., Pascoe, Chris D., Arsenault, Bryna A., Postma, Dirkje S., Boezen, Marike H., Bossé, Yohan, van den Berge, Maarten, Hiemstra, Pieter S., Cho, Michael H., Litonjua, Augusto A., Sparrow, David, Ober, Carole, Wise, Robert A., Connett, John, Neptune, Enid R., Beaty, Terri H., Ruczinski, Ingo, Mathias, Rasika A., and Barnes, Kathleen C.

Published
2015
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15. Genome-wide study identifies two loci associated with lung function decline in mild to moderate COPD

Author

Hansel, Nadia N., Ruczinski, Ingo, Rafaels, Nicholas, Sin, Don D., Daley, Denise, Malinina, Alla, Huang, Lili, Sandford, Andrew, Murray, Tanda, Kim, Yoonhee, Vergara, Candelaria, Heckbert, Susan R., Psaty, Bruce M., Li, Guo, Elliott, W. Mark, Aminuddin, Farzian, Dupuis, Josée, O’Connor, George T., Doheny, Kimberly, Scott, Alan F., Boezen, H. Marike, Postma, Dirkje S., Smolonska, Joanna, Zanen, Pieter, Mohamed Hoesein, Firdaus A., de Koning, Harry J., Crystal, Ronald G., Tanaka, Toshiko, Ferrucci, Luigi, Silverman, Edwin, Wan, Emily, Vestbo, Jorgen, Lomas, David A., Connett, John, Wise, Robert A., Neptune, Enid R., Mathias, Rasika A., Paré, Peter D., Beaty, Terri H., and Barnes, Kathleen C.

Published
2013
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16. Correction: Pharmacogenomic associations of adverse drug reactions in asthma: systematic review and research prioritization (The Pharmacogenomics Journal, (2020), 20, 5, (621-628), 10.1038/s41397-019-0140-y)

Author

King, Charlotte, McKenna, Amanda, Farzan, Niloufar, Vijverberg, Susanne J., van der Schee, Marc P., Maitland-van der Zee, Anke H., Arianto, Lambang, Bisgaard, Hans, BØnnelykke, Klaus, Berce, Vojko, PotoČnik, Uros, Repnik, Katja, Carleton, Bruce, Daley, Denise, Chew, Fook Tim, Chiang, Wen Chin, Sio, Yang Yie, Cloutier, Michelle M., den Dekker, Herman T., Duijts, Liesbeth, de Jongste, Johan C., Dijk, F. Nicole, Flores, Carlos, Hernandez-Pacheco, Natalia, Mukhopadhyay, Somnath, Basu, Kaninika, Tantisira, Kelan G., Verhamme, Katia M., Celedón, Juan C., Forno, Erick, Canino, Glorisa, Francis, Ben, Pirmohamed, Munir, Sinha, Ian, Hawcutt, Daniel B., Pulmonology, AII - Inflammatory diseases, APH - Personalized Medicine, and Paediatric Pulmonology

Abstract

The original version of this article did not include Juan C. Celedón, Erick Forno and Glorisa Canino in the list of authors and incorrectly cited Gerard H. Koppelman, Maria Pino-Yanes and Steve Turner as authors. This has now been corrected in both the PDF and HTML versions of the article.

Published
2020

17. Analyses of associations with asthma in four asthma population samples from Canada and Australia

Author

Daley, Denise, Lemire, Mathieu, Akhabir, Loubna, Chan-Yeung, Moira, He, Jian Qing, McDonald, Treena, Sandford, Andrew, Stefanowicz, Dorota, Tripp, Ben, Zamar, David, Bosse, Yohan, Ferretti, Vincent, Montpetit, Alexandre, Tessier, Marie-Catherine, Becker, Allan, Kozyrskyj, Anita L., Beilby, John, McCaskie, Pamela A., Musk, Bill, Warrington, Nicole, James, Alan, Laprise, Catherine, Palmer, Lyle J., Paré, Peter D., and Hudson, Thomas J.

Published
2009
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18. Identification of susceptibility genes for cancer in a genome-wide scan: results from the colon neoplasia sibling study

Author

Daley, Denise, Lewis, Susan, Platzer, Petra, MacMillen, Melissa, Willis, Joseph, Elston, Robert C., Markowitz, Sanford D., and Wiesner, Georgia L.

Subjects
Colorectal cancer -- Genetic aspects, Colorectal cancer -- Research, Genetic susceptibility -- Research, Phenotype -- Research, Biological sciences
Abstract

The colon neoplasia sibling study is employed to conduct a comprehensive genome-wide scan for the identification of susceptibility genes for cancer. The analysis of the detailed clinical information, unaffected siblings and family history was found to be extremely beneficial for the linkage study.

Published
2008

23. Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks

Author

Demenais, Florence, Margaritte-Jeannin, Patricia, Barnes, Kathleen C, Cookson, William O. C. M., Altmüller, Janine, Ang, Wei, Barr, R Graham, Beaty, Terri H, Becker, Allan B, Beilby, John, Bisgaard, Hans, Bjornsdottir, Unnur Steina, Bleecker, Eugene, Bønnelykke, Klaus, Boomsma, Dorret I, Bouzigon, Emmanuelle, Brightling, Christopher E, Brossard, Myriam, Brusselle, Guy G, Burchard, Esteban G., Burkart, Kristin M, Bush, Andrew, Chan-Yeung, Moira, Chung, Kian Fan, Da Silva Couto Alves, Alexessander, Curtin, John A, Custovic, Adnan, Daley, Denise, de Jongste, Johan C, Del-Rio-Navarro, Blanca E, Donohue, Kathleen M, Duijts, Liesbeth, Eng, Celeste, Eriksson, Johan G, Farrall, Martin, Fedorova, Yuliya, Feenstra, Bjarke, Ferreira, Manuel A, Freidin, Maxim B., Gajdos, Zofia, Gauderman, Jim, Gehring, Ulrike, Geller, Frank, Genuneit, Jon, Gharib, Sina A, Gilliland, Frank, Granell, Raquel, Graves, Penelope E, Heederik, Dick, Wouters, Inge M, Australian Asthma Genetics Consortium (AAGC) collaborators, One Health Chemisch, One Health Microbieel, dIRAS RA-I&I RA, dIRAS RA-2, and Dep IRAS

Subjects
Coronacrisis-Taverne
Abstract

We examined common variation in asthma risk by conducting a meta-analysis of worldwide asthma genome-wide association studies (23,948 asthma cases, 118,538 controls) of individuals from ethnically diverse populations. We identified five new asthma loci, found two new associations at two known asthma loci, established asthma associations at two loci previously implicated in the comorbidity of asthma plus hay fever, and confirmed nine known loci. Investigation of pleiotropy showed large overlaps in genetic variants with autoimmune and inflammatory diseases. The enrichment in enhancer marks at asthma risk loci, especially in immune cells, suggested a major role of these loci in the regulation of immunologically related mechanisms.

Published
2018

25. Asthma and genes encoding components of the vitamin D pathway

Author

Raby Benjamin A, Palmer Lyle J, Musk Arthur, James Alan L, White John H, Sandford Andrew, He Jian-Qing, Daley Denise, Poon Audrey H, Lemire Mathieu, Bossé Yohan, Weiss Scott T, Kozyrskyj Anita L, Becker Allan, Hudson Thomas J, and Laprise Catherine

Subjects
Diseases of the respiratory system, RC705-779
Abstract

Abstract Background Genetic variants at the vitamin D receptor (VDR) locus are associated with asthma and atopy. We hypothesized that polymorphisms in other genes of the vitamin D pathway are associated with asthma or atopy. Methods Eleven candidate genes were chosen for this study, five of which code for proteins in the vitamin D metabolism pathway (CYP27A1, CYP27B1, CYP2R1, CYP24A1, GC) and six that are known to be transcriptionally regulated by vitamin D (IL10, IL1RL1, CD28, CD86, IL8, SKIIP). For each gene, we selected a maximally informative set of common SNPs (tagSNPs) using the European-derived (CEU) HapMap dataset. A total of 87 SNPs were genotyped in a French-Canadian family sample ascertained through asthmatic probands (388 nuclear families, 1064 individuals) and evaluated using the Family Based Association Test (FBAT) program. We then sought to replicate the positive findings in four independent samples: two from Western Canada, one from Australia and one from the USA (CAMP). Results A number of SNPs in the IL10, CYP24A1, CYP2R1, IL1RL1 and CD86 genes were modestly associated with asthma and atopy (p < 0.05). Two-gene models testing for both main effects and the interaction were then performed using conditional logistic regression. Two-gene models implicating functional variants in the IL10 and VDR genes as well as in the IL10 and IL1RL1 genes were associated with asthma (p < 0.0002). In the replicate samples, SNPs in the IL10 and CYP24A1 genes were again modestly associated with asthma and atopy (p < 0.05). However, the SNPs or the orientation of the risk alleles were different between populations. A two-gene model involving IL10 and VDR was replicated in CAMP, but not in the other populations. Conclusion A number of genes involved in the vitamin D pathway demonstrate modest levels of association with asthma and atopy. Multilocus models testing genes in the same pathway are potentially more effective to evaluate the risk of asthma, but the effects are not uniform across populations.

Published
2009
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26. Lack of association of TIM3 polymorphisms and allergic phenotypes

Author

Laprise Catherine, Becker Allan B, Chan-Yeung Moira, Stefanowicz Dorota, Akhabir Loubna, Daley Denise, Zhang Jian, Paré Peter D, and Sandford Andrew J

Subjects
Internal medicine, RC31-1245, Genetics, QH426-470
Abstract

Abstract Background T-cell immunoglobulin mucin-3 (TIM3) is a TH1-specific type 1 membrane protein that regulates TH1 proliferation and the development of immunological tolerance. TIM3 and its genetic variants have been suggested to play a role in regulating allergic diseases. Polymorphisms in the TIM3 promoter region have been reported to be associated with allergic phenotypes in several populations. The aims of this study were to examine whether genetic variation in the promoter region of TIM3 influenced transcription of the gene and risk for allergic phenotypes. Methods We performed 5' rapid amplification of cDNA ends and reverse transcription-polymerase chain reaction. We screened for polymorphisms in the promoter region. Deletion analysis was used to localize the promoter region of TIM3. Genotyping was performed by TaqMan assays in three asthma/allergy population samples. Results We found two regions with promoter activity in TIM3. One region was from -214 bp to +58 bp and the other from -1.6 kb to -914 bp relative to the transcription start site. None of the single nucleotide polymorphisms (SNPs) or haplotypes affected the transcriptional activity in reporter gene assays. No association between the SNPs and any phenotype was observed in the study cohorts. Conclusion Our findings indicate that SNPs and haplotypes in the TIM3 promoter region do not have a functional effect in vitro and are not associated with allergic diseases. These data suggest that polymorphisms in the TIM3 promoter region are unlikely to play an important role in susceptibility to allergic diseases.

Published
2009
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27. A three-year whole genome sequencing perspective of Enterococcus faecium sepsis in Australia.

Author

Lee, Terence, Pang, Stanley, Stegger, Marc, Sahibzada, Shafi, Abraham, Sam, Daley, Denise, and Coombs, Geoffrey

Subjects
ENTEROCOCCAL infections, ENTEROCOCCUS faecium, NUCLEOTIDE sequencing, DRUG resistance in microorganisms, SINGLE nucleotide polymorphisms, VANCOMYCIN resistance
Abstract

Background: Over the last three decades, hospital adapted clonal complex (CC) 17 strains of Enterococcus faecium have acquired and exchanged antimicrobial resistance genes leading to the widespread resistance to clinically important antimicrobials globally. In Australia, a high prevalence of vancomycin resistance has been reported in E. faecium in the last decade. Methods: In this study, we determined the phylogenetic relationship and genetic characteristics of E. faecium collected from hospitalized patients with blood stream infections throughout Australia from 2015 to 2017 using high throughput molecular techniques. Results: Using single nucleotide polymorphism based phylogenetic inference, three distinct clusters of isolates were observed with additional sub-clustering. One cluster harboured mostly non-CC17 isolates while two clusters were dominant for the vanA and vanB operons. Conclusion: The gradual increase in dominance of the respective van operon was observed in both the vanA and vanB dominant clusters suggesting a strain-van operon affinity. The high prevalence of the van operon within isolates of a particular sub-cluster was linked to an increased number of isolates and 30-day all-cause mortality. Different dominant sub-clusters were observed in each region of Australia. Findings from this study can be used to put future surveillance data into a broader perspective including the detection of novel E. faecium strains in Australia as well as the dissemination and evolution of each strain. [ABSTRACT FROM AUTHOR]

Published
2020
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28. WAO International Scientific Conference (WISC 2016) Abstracts

Author

Bao, Jun, Wang, Yi-Hui, Liu, Quan-Hua, Bao, Yi-Xiao, Azouz, Nurit, Caldwell, Julie, Ray, Leanne, Rochman, Mark, Mingler, Melissa, Eilerman, Matthew, Wen, Ting, Myers, Jocelyn Biagini, Hershey, Gurjit Khurana, Kottyan, Leah, Martin, Lisa, Marc, Rothenberg, Gonzalez-Uribe, Victor, Del Rio-Chivardi, Jaime, Del Rio-Navarro, Blanca, Lou, Hongfei, Ma, Siyuan, Zhao, Yan, Cao, Feifei, He, Fei, Liu, Zhongyan, Wang, Chengshuo, Bachert, Claus, Zhang, Luo, Abrams, Elissa, Becker, Allan, Kandhare, Amit, Bodhankar, Subhash, Grossman, Nicole, Doros, Gheorghe, Laden, Francine, Fuhlbrigge, Anne, Wechsler, Michael, Pace, Wilson, Yawn, Barbara, Israel, Elliot, Lee, Junehyuk, Adler, Frederick, Kim, Peter, Huang, Yung Feng, Chen, Ying Yao, Pan, Chiun Yen, Lee, Herng Sheng, Khalemsky, Michael, Schwartz, David G., Kolkhir, Pavel, Pogorelov, Dmitry, Kochergin, Nikolay, Komarow, Hirsh, Young, Michael, Eisch, Robin, Scott, Linda, Metcalfe, Dean, Singer, Alexander, Wakeman, Andrew, Gerstner, Thomas, Song, Woo-Jung, Shim, Ji-Su, Won, Ha-Kyeong, Kang, Sung-Yoon, Sohn, Kyoung-Hee, Kim, Byung-Keun, Jo, Eun-Jung, Kim, Min-Hye, Kim, Sang-Heon, Park, Heung-Woo, Kim, Sun-Sin, Chang, Yoon-Seok, Morice, Alyn H., Lee, Byung-Jae, Cho, Sang-Heon, Min, Kyung-Up, Boscolo, Maria Assunta, Brivio, Giulio, Bosisio, Sergio, Manzocchi, Nicoletta, Pulixi, Edoardo, Grignani, Giulia, D’Andrea, Eloisia, Ricci, Massimo, Passini, Elena, Italia, Maurizio, Urrutia-Pereira, Marilyn, Fagundes, Stefani, Oliano, Vinicius Jardim, Solé, Dirceu, Benzaquen, Sadia, Aragaki, Alejandro, Balestra, Ricardo, Harden, Dawn, Caudell-Stamper, Danielle, Glady, Gilbert, Holbreich, Mark, Lyakhovska, Nataliya, Kaidashev, Igor, Bystron, Jaromir, Hutyrova, Beata, Balakirski, Galina, Vanstreels, Luk, Wurpts, Gerda, Merk, Hans F., Baron, Jens Malte, Plange, Johanna, Rihs, Hans-Peter, Raulf, Monika, Roeseler, Stefani, Tolcachier, Alberto, Chamorro, Armando, Otero, Ruth, Brooks, Joel, Hess, Michael, Benz, Jared, MacDonald, Joseph, Chatha, Usma, Lent, Dale, Köse, Şükran, Tatar, Bengü Gireniz, Akkoçlu, Gülgün, Çukurova, İbrahim, Ödemiş, İlker, Toker, Ayşin Kılınç, Hasssan, Abdullahi, Gobir, Abdulrazaq Abdullahi, Kim, Cheol-Woo, Choi, Young Hwa, Lee, Jeong Hye, Cho, Rae Jeong, Nam, Yu Ran, Nam, Joo Hyun, Kim, Woo Kyung, Filipovic, Ivana, Zivkovic, Zorica, Filipovic, Djordje, Shik, Dana, Smith, Andrew, Hsi, Wang Yui, Friedman, Stuart, Gizaw, Yonatan, Bakhda, Rima, Mohammed, Kumail, Wasserman, Richard, Hague, Angela, Pence, Deanna, Rolen, Joanna, Sugerman, Robert, Silvers, Stacy, Kamili, Qurat, Knauer, Nadezhda, Zazernyi, Alexandr, Blinova, Elena, Demina, Daria, Kozlov, Vladimir, Agrawal, Komal, Kale, Sagar, Arora, Naveen, Vasilkova, Volha, Mokhort, Tatiana, Silvers, William, Eisenberg, Rachel, Mehta, Rushita, Rubinstein, Arye, Aston, Antony, Turner, Paul, Ruiz-Garcia, Monica, Boyle, Robert, Brown, Simon, Schejter, Yael Dinur, Ovadia, Adi, Kim, Vy, Reid, Brenda, Roifman, Chaim, Rosenfield, Lana, Avilla, Ernie, Harada, Laurie, Allen, Marilyn, Waserman, Susan, Yoon, Ho Joo, Koo, Gun Woo, Chang, Suk-Il, Yoon, Hye-Ran, Park, Dong Won, Park, Tai Sun, Moon, Ji-Yong, Kim, Tae Hyung, Sohn, Jang Won, Shin, Dong Ho, Jorjoliani, Tsici, Jorjoliani, Lia, Adamia, Nino, katamadze, Nona, Ramachandra, Deepika, Jorjoliani, Liana, Karseladze, Rusudan, Saginadze, Lali, Chkuaseli, Natalia, Dolgova, Anna, Stukolova, Olga, Sudina, Anna, Cherkashina, Anna, Shipulin, German, Rosenthal, Richard, Howe, Harvey, Knause, Paul, Greemberg, Rony, De Bruycker, Jean Jacques, Fernandez, Isabel, Le Deist, Françoise, Haddad, Elie, Rha, Yeong Ho, Lee, Kyung Suk, Choi, Sun Hee, Tam, Herman, Simons, Estelle, Simons, Elinor, Golebiowska-Wawrzyniak, Maria, Markiewicz, Katarzyna, Faitelson, Yoram, Stein, Miguel, Mandelberg, Avigdor, Dalal, Ilan, Levin, Michael, Hobane, Lelani, Basera, Wisdom, Botha, Maresa, Gray, Claudia, Zar, Heather, Kjaeva, Biserka Jovkovska, Arsovski, Zoran, Grivcheva-Panovska, Vesna, Odebode, Adeyinka, Adekunle, Adedotun, Adeonipekun, Peter, Farombi, Ebenezer, Camacho-Ordoñez, Nadezhda, Martinez-Vázquez, Alejandrina Josefina, García-Cruz, María de la Luz H., Tan, Qi, Min, Rui, Dai, Guan-qun, Xie, Wei-Ping, Mao, Huang, Wang, Hong, Yadav, Rakesh, Singh, Sneha, Yadav, Divya, Khaleva, Ekaterina, Bahnson, Henry T., Franz, Amber, Garvey, Lene Heise, Jay, Nicola, Haque, Rubaiyat, Fox, Adam, Lack, Gideon, du Toit, George, Radic, Snezana, Milenkovic, Branislava, Neskovic, Ana, Danojevic, Ljiljana, Nachshon, Liat, Goldberg, Michael, Levy, Michael, Katz, Yitzhak, Elizur, Arnon, Rosario, Cristine, Kasper, Juliana, Chong-Neto, Herbeto, Riedi, Carlos, Rosario, Nelson, Levy, Michael B., Har-Even, Ronly, Carmel, Mor, Goldberg, Michael R., Kherkheulidze, Maia, Kavlashvili, Nani, Kandelaki, Eka, Adamai, Nino, Ubiria, Irma, Burke, Andrea, Kastner, Monika, Zheleva, Denica, Darlenski, Razvigor, Bozinakis, Konstantinos, Kriebardis, Anastasios, Styliara, Sofia, Karastathi, Aikaterini, Farmakas, Nikolaos, Ribeiro, Maria Luiza Kraft Kohler, Barcellos, Ana Carolina, Silva, Hannah Gabriele Ferreira, Carletto, Luís Henrique Mattei, Bet, Marcela Carolina, Rossetto, Nathalia Zorze, Rosario, Nelson Augusto, Chong-Neto, Herberto Jose, Valença, Fernanda, Novaes, Marina, Gomes, Mariana, Seifert, Carla, Neto, Alfredo, Loyola, Flavia, Rios, José, Silva, Tatiana, Neves, Aline, Abadoglu, Oznur, Gemicioglu, Bilun, Bayram, Hasan, Cimrin, Arif, Akyildiz, Levent, Cilli, Aykut, Gunen, Hakan, Ozlu, Tevfik, Suerdem, Mecit, Uzaslan, Esra, Misirligil, Zeynep, Ristic-Stojanovic, Snezana, Milicevic, A., Milenkovic, A., Cvejic, Jelena, Jankovic, Jelena, Dimic-Janjic, Sanja, Djurdjevic, Natasa, Barzylovych, Vladyslava, Umanets, Tetiana, Barzylovych, Anastasia, Winkler, Karyn, Margarinos, Jessica, Martin, Dylan, Nowakowski, Maja, Joks, Rauno, Zangen, Tsili, Bernadsky, Olga, Boaz, Mona, Hermann, Gratiana, Aviv, Rachel, Kuperboim, Olga, Ramichanov, Larisa, Broide, Efrat, Shamir, Raanan, Zevit, Noam, Shaoul, Ron, Fich, Alex, Levine, Arie, Melamed, Isaac, Gangwar, Roopesh Singh, Minai-Fleminger, Yael, Seaf, Mansour, Gutgold, Amichai, Shikotra, Aarti, Chauhan, Anoop, Holgate, Stephen, Bradding, Peter, Howarth, Peter, Eliashar, Ron, Berkman, Neville, Levi-Schaffer, Francesca, Woo, Sung-il, Celik, Betul, Bulut, Tangul, Yalcin, Arzu Didem, Caldas, Luiz Querino, Confino-Cohen, Ronit, Rosman, Yossi, Goldberg, Arnon, Breuer, Oded, Singh, Roopesh, Barhoum, Ahlam, Kerem, Eitan, Slavyanskaya, Tatiana, Sepiashvili, Revaz, Blinova, Elena A., Pashkina, Ekaterina A., Leonova, Marina I., Nepomnyaschikh, Vera M., Demina, Darya V., Kozlov, Vladimir A., Shamri, Revital, Young, Kristen M., Weller, Peter F., de Paula Vieira, Rodolfo, Oliveira-Junior, Manoel Carneiro, Damasceno-Rodrigues, Nilsa Regina, Arantes-Costa, Fernanda Magalhães, Martins, Milton Arruda, Oliveira, Ana Paula Ligeiro, Bernard, Alfred, Sardella, Antonia, Voisin, Catherine, Royce, Simon, Philpott, Hamish, Nandurkar, Sanjay, Thien, Francis, Gibson, Peter, Bianchini, Rodolfo, Roth-Walter, Franziska, Ohradanova-Repic, Anna, Hofstetter, Gerlinde, Herrmann, Ina, Carvalho, Maria Isabel, Hufnagl, Karin, Bajna, Erika, Roth, Georg, Stockinger, Hannes, Jensen-Jarolim, Erika, Almog, Meital, Kessel, Aharon, Apov, Larisa, Salguero, Carlos Sanchez, Chacon, Alvaro Sanchez, Nazarov, Abbos, Ergashev, Shaxbos, Nesterova, Irina, Kovaleva, Svetlana, Chudilova, Galina, Lomtatidze, Ludmila, De Schryver, Sarah, Dery, Alizee, Clarke, Ann, Nadeau, Kari, Weatherall, Kimberly, Greenwood, Celia, Daley, Denise, Asai, Yuka, Ben-Shoshan, Moshe, Balmasova, Irina, Malova, Elena, Wagner, Stefanie, Pacios, Luis F., Wallner, Michael, Wiederstein, Markus, Tevs, Anna E., Tataurshchikova, Nataly, Sangidorj, Baigalmaa, Ronzhina, Anna, Chikhladze, Manana, Wirz, Oliver F., van de Veen, Willem, Mirer, David, Morita, Hideaki, Altunbulakli, Can, Johnston, Sebastian L., Glanville, Nicholas, Papadopoulos, Nikolaos G., Akdis, Cezmi A., Akdis, Mübeccel, Reshef, Avner, Riedl, Marc, Panovska, Vesna Grivcheva, Moldovan, Dumitru, Baker, James, Yang, William H., Andrejevic, Sladjana, Lockey, Richard F., Hakl, Roman, Kivity, Shmuel, Bellizzi, Luca, Harper, Joseph R., Relan, Anurag, and Cicardi, Marco

Subjects
lcsh:Immunologic diseases. Allergy, Pulmonary and Respiratory Medicine, 010504 meteorology & atmospheric sciences, business.industry, Immunology, Library science, Meeting Abstracts, 01 natural sciences, 03 medical and health sciences, 0302 clinical medicine, 030228 respiratory system, Immunology and Allergy, Medicine, lcsh:RC581-607, business, 0105 earth and related environmental sciences, Wechsler Intelligence Scale for Children
Published
2017

29. Genetic Variation in Cell Death Genes and Risk of Non-Hodgkin Lymphoma

Author

Brooks-Wilson, Angela, Schuetz, Johanna, Daley, Denise, Graham, Ginko, Berry, Brian, Gallagher, Richard, Spinelli, John, Connors, Joseph, and Gascoyne, Randy

Abstract

Background Non-Hodgkin lymphomas are a heterogeneous group of solid tumours that constitute the 5th highest cause of cancer mortality in the United States and Canada. Poor control of cell death in lymphocytes can lead to autoimmune disease or cancer, making genes involved in programmed cell death of lymphocytes logical candidate genes for lymphoma susceptibility. Materials and Methods We tested for genetic association with NHL and NHL subtypes, of SNPs in lymphocyte cell death genes using an established population-based study. 17 candidate genes were chosen based on biological function, with 123 SNPs tested. These included tagSNPs from HapMap and novel SNPs discovered by re-sequencing 47 cases in genes for which SNP representation was judged to be low. The main analysis, which estimated odds ratios by fitting data to an additive logistic regression model, used European ancestry samples that passed quality control measures (569 cases and 547 controls). A two-tiered approach for multiple testing correction was used: correction for number of tests within each gene by permutation-based methodology, followed by correction for the number of genes tested using the false discovery rate. Results Variant rs928883, near miR-155, showed an association (OR per A-allele: 2.80 [95% CI: 1.63–4.82]; pF = 0.027) with marginal zone lymphoma that is significant after correction for multiple testing. Conclusions This is the first reported association between a germline polymorphism at a miRNA locus and lymphoma.

Published
2012

30. A Large-Scale, Consortium-Based Genomewide Association Study of Asthma

Author

Moffatt, Miriam F. Gut, Ivo G. Demenais, Florence Strachan, David P. Bouzigon, Emmanuelle Heath, Simon von Mutius, Erika and Farrall, Martin Lathrop, Mark Cookson, William O. C. M. and Kumar, Ashish Burney, Peter Jarvis, Debbie Wjst, Matthias and Kogevinas, Manolis Jogi, Rain Janson, Christer Franklin, Karl A. Omenaas, Ernst Leynaert, Benedicte Pin, Isabelle and Heinrich, Joachim Probst-Hensch, Nicole M. Anto, Josep M. and Sunyer, Jordi Maldonado, Jose-Antonio Martinez-Moratalla, Jesus and Urrutia, Isabel Payo, Felix Kauffmann, Francine Dizier, Marie-Helene Siroux, Valerie Boznanski, Andrzej and Braun-Fahrlaender, Charlotte Genuneit, Jon Glas, Juergen and Horak, Elisabeth Kabesch, Michael Pillai, Sreekumar G. and Helms, Peter J. Carlsen, Karin Carlsen, Kai-Hakon Gerritsen, Jorrit Silverman, Michael Sly, Peter Tsanakas, John Von Berg, Andrea Whyte, Moira Blumenthal, Malcolm Imboden, Medea and Rochat, Thierry Thun, Gian Andri Gerbase, Margaret W. and Curjuric, Ivan Gaspoz, Jean-Michel Liu, Lee-Jane S. Wouters, Inge M. Sigsgaard, Torben Heederik, Dick Basinas, Ioannis and Schlunssen, Vivi Omland, Oyvind Cullinan, Paul and Vermeulen, Roel Henderson, John Granell, Raquel McArdle, Wendy L. Smith, George Davey James, Alan L. Hui, Jennie and Palmer, Lyle J. Beilby, John Musk, A. William Laprise, Catherine Hudson, Thomas J. Lemire, Mathieu Daley, Denise and Becker, Allan Chan-Yeung, Moira Sandford, Andrew and Kozyrskyj, Anita L. Pare, Peter Ferguson, Alexander and Dimich-Ward, Helen Watson, Wade T. Freidin, Maxim B. and Bragina, Elena Iu. Deev, Ivan A. Deeva, Eugenia V. and Kobyakova, Olga S. Puzyrev, Valery P. Ogorodova, Ludmila M. and Khusnutdinova, Elza K. Karunas, Alexandra S. Fedorova, Yuliya Y. and Hall, Ian P. Sayers, Ian Tobin, Martin D. Wan, Yize I. and Heaney, Liam G. Al-Momani, Basima A. H. Mansur, Adel H. and Manney, Sarah Thomson, Neil C. Chaudhuri, Rekha Brightling, Christopher E. Bafadhel, Mona Singapuri, Amisha Niven, Robert Simpson, Angela Holloway, John W. Howarth, Peter H. and Polonikov, Alexey V. Ivanov, Vladimir P. Solodilova, Maria A. Melen, Erik Pershagen, Goeran Bergstroem, Anna Kull, Inger Nyberg, Fredrik Wickman, Magnus Soderhall, Cilla and Kere, Juha Postma, Dirkje S. Kerkhof, Marjan Brunekreef, Bert Smit, Henriette A. de Jongste, Johan C. Wijga, Alet and Aalberse, R. C. Hoekstra, Maarten O. Koppelman, Gerard H. and Binia, Aristea Chung, Kian Fan Bhavsar, Pankaj Chow, Florence Macedo, Patricia Menzies-Gow, Andrew van Stiphout, Nicole Bush, Andrew Lee, Young-Ae Esparza-Gordillo, Jorge and Nickel, Renate Wahn, Ulrich Lau, Susanne Marenholz, Ingo and Haahtela, Tari von Hertzen, Leena Jousilahti, Pekka and Laatikainen, Tiina Makela, Mika J. Vartiainen, Erkki and Laitinen, Tarja Balding, David J. Peden, John F. Corda, Eve and Lechner, Doris Besse, Celine Zelenika, Diana Boland, Anne Bacq, Delphine Demonchy, Stephanie Blanche, Helene and Kamatani, Yoichiro von Mutius, Erika Farrall, Martin and Lathrop, Mark Cookson, William O. C. M. GABRIEL Consortium

Abstract

BACKGROUND Susceptibility to asthma is influenced by genes and environment; implicated genes may indicate pathways for therapeutic intervention. Genetic risk factors may be useful in identifying subtypes of asthma and determining whether intermediate phenotypes, such as elevation of the total serum IgE level, are causally linked to disease. METHODS We carried out a genomewide association study by genotyping 10,365 persons with physician-diagnosed asthma and 16,110 unaffected persons, all of whom were matched for ancestry. We used random-effects pooled analysis to test for association in the overall study population and in subgroups of subjects with childhood-onset asthma (defined as asthma developing before 16 years of age), later-onset asthma, severe asthma, and occupational asthma. RESULTS We observed associations of genomewide significance between asthma and the following single-nucleotide polymorphisms: rs3771166 on chromosome 2, implicating IL1RL1/IL18R1 (P = 3x10(-9)); rs9273349 on chromosome 6, implicating HLA-DQ (P = 7x10(-14)); rs1342326 on chromosome 9, flanking IL33 (P = 9x10(-10)); rs744910 on chromosome 15 in SMAD3 (P = 4x10(-9)); and rs2284033 on chromosome 22 in IL2RB (P = 1.1x10(-8)). Association with the ORMDL3/GSDMB locus on chromosome 17q21 was specific to childhood-onset disease (rs2305480, P = 6x10(-23)). Only HLA-DR showed a significant genomewide association with the total serum IgE concentration, and loci strongly associated with IgE levels were not associated with asthma. CONCLUSIONS Asthma is genetically heterogeneous. A few common alleles are associated with disease risk at all ages. Implicated genes suggest a role for communication of epithelial damage to the adaptive immune system and activation of airway inflammation. Variants at the ORMDL3/GSDMB locus are associated only with childhood-onset disease. Elevation of total serum IgE levels has a minor role in the development of asthma.

Published
2010

31. Practical Barriers and Ethical Challenges in Genetic Data Sharing

Author

Simpson, Claire, primary, Goldenberg, Aaron, additional, Culverhouse, Rob, additional, Daley, Denise, additional, Igo, Robert, additional, Jarvik, Gail, additional, Mandal, Diptasri, additional, Mascalzoni, Deborah, additional, Montgomery, Courtney, additional, Pierce, Brandon, additional, Plaetke, Rosemarie, additional, Shete, Sanjay, additional, Goddard, Katrina, additional, and Stein, Catherine, additional

Published
2014
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32. Genes, the environment and personalized medicine

Author

Carlsten, Chris, primary, Brauer, Michael, additional, Brinkman, Fiona, additional, Brook, Jeffrey, additional, Daley, Denise, additional, McNagny, Kelly, additional, Pui, Mandy, additional, Royce, Diana, additional, Takaro, Tim, additional, and Denburg, Judah, additional

Published
2014
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33. Molecular Epidemiology of Enterococcal Bacteremia in Australia

Author

Coombs, Geoffrey W., primary, Pearson, Julie C., additional, Daley, Denise A., additional, Le, Tam, additional, Robinson, Owen J., additional, Gottlieb, Thomas, additional, Howden, Benjamin P., additional, Johnson, Paul D. R., additional, Bennett, Catherine M., additional, Stinear, Timothy P., additional, and Turnidge, John D., additional

Published
2014
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34. Whole-Exome Sequencing Identifies Rare and Low-Frequency Coding Variants Associated with LDL Cholesterol

Author

Lange, Leslie A., primary, Hu, Youna, additional, Zhang, He, additional, Xue, Chenyi, additional, Schmidt, Ellen M., additional, Tang, Zheng-Zheng, additional, Bizon, Chris, additional, Lange, Ethan M., additional, Smith, Joshua D., additional, Turner, Emily H., additional, Jun, Goo, additional, Kang, Hyun Min, additional, Peloso, Gina, additional, Auer, Paul, additional, Li, Kuo-ping, additional, Flannick, Jason, additional, Zhang, Ji, additional, Fuchsberger, Christian, additional, Gaulton, Kyle, additional, Lindgren, Cecilia, additional, Locke, Adam, additional, Manning, Alisa, additional, Sim, Xueling, additional, Rivas, Manuel A., additional, Holmen, Oddgeir L., additional, Gottesman, Omri, additional, Lu, Yingchang, additional, Ruderfer, Douglas, additional, Stahl, Eli A., additional, Duan, Qing, additional, Li, Yun, additional, Durda, Peter, additional, Jiao, Shuo, additional, Isaacs, Aaron, additional, Hofman, Albert, additional, Bis, Joshua C., additional, Correa, Adolfo, additional, Griswold, Michael E., additional, Jakobsdottir, Johanna, additional, Smith, Albert V., additional, Schreiner, Pamela J., additional, Feitosa, Mary F., additional, Zhang, Qunyuan, additional, Huffman, Jennifer E., additional, Crosby, Jacy, additional, Wassel, Christina L., additional, Do, Ron, additional, Franceschini, Nora, additional, Martin, Lisa W., additional, Robinson, Jennifer G., additional, Assimes, Themistocles L., additional, Crosslin, David R., additional, Rosenthal, Elisabeth A., additional, Tsai, Michael, additional, Rieder, Mark J., additional, Farlow, Deborah N., additional, Folsom, Aaron R., additional, Lumley, Thomas, additional, Fox, Ervin R., additional, Carlson, Christopher S., additional, Peters, Ulrike, additional, Jackson, Rebecca D., additional, van Duijn, Cornelia M., additional, Uitterlinden, André G., additional, Levy, Daniel, additional, Rotter, Jerome I., additional, Taylor, Herman A., additional, Gudnason, Vilmundur, additional, Siscovick, David S., additional, Fornage, Myriam, additional, Borecki, Ingrid B., additional, Hayward, Caroline, additional, Rudan, Igor, additional, Chen, Y. Eugene, additional, Bottinger, Erwin P., additional, Loos, Ruth J.F., additional, Sætrom, Pål, additional, Hveem, Kristian, additional, Boehnke, Michael, additional, Groop, Leif, additional, McCarthy, Mark, additional, Meitinger, Thomas, additional, Ballantyne, Christie M., additional, Gabriel, Stacey B., additional, O’Donnell, Christopher J., additional, Post, Wendy S., additional, North, Kari E., additional, Reiner, Alexander P., additional, Boerwinkle, Eric, additional, Psaty, Bruce M., additional, Altshuler, David, additional, Kathiresan, Sekar, additional, Lin, Dan-Yu, additional, Jarvik, Gail P., additional, Cupples, L. Adrienne, additional, Kooperberg, Charles, additional, Wilson, James G., additional, Nickerson, Deborah A., additional, Abecasis, Goncalo R., additional, Rich, Stephen S., additional, Tracy, Russell P., additional, Willer, Cristen J., additional, Altshuler, David M., additional, Abecasis, Gonçalo R., additional, Allayee, Hooman, additional, Cresci, Sharon, additional, Daly, Mark J., additional, de Bakker, Paul I.W., additional, DePristo, Mark A., additional, Donnelly, Peter, additional, Fennell, Tim, additional, Garimella, Kiran, additional, Hazen, Stanley L., additional, Jordan, Daniel M., additional, Kiezun, Adam, additional, Lettre, Guillaume, additional, Li, Bingshan, additional, Li, Mingyao, additional, Newton-Cheh, Christopher H., additional, Padmanabhan, Sandosh, additional, Pulit, Sara, additional, Rader, Daniel J., additional, Reich, David, additional, Reilly, Muredach P., additional, Schwartz, Steve, additional, Scott, Laura, additional, Spertus, John A., additional, Stitziel, Nathaniel O., additional, Stoletzki, Nina, additional, Sunyaev, Shamil R., additional, Voight, Benjamin F., additional, Akylbekova, Ermeg, additional, Atwood, Larry D., additional, Barbalic, Maja, additional, Barr, R. Graham, additional, Benjamin, Emelia J., additional, Bis, Joshua, additional, Bowden, Donald W., additional, Brody, Jennifer, additional, Budoff, Matthew, additional, Burke, Greg, additional, Buxbaum, Sarah, additional, Carr, Jeff, additional, Chen, Donna T., additional, Chen, Ida Y., additional, Chen, Wei-Min, additional, Concannon, Pat, additional, D’Agostino, Ralph, additional, DeStefano, Anita L., additional, Dreisbach, Albert, additional, Dupuis, Josée, additional, Durda, J. Peter, additional, Ellis, Jaclyn, additional, Fox, Caroline S., additional, Fox, Ervin, additional, Funari, Vincent, additional, Ganesh, Santhi K., additional, Gardin, Julius, additional, Goff, David, additional, Gordon, Ora, additional, Grody, Wayne, additional, Gross, Myron, additional, Guo, Xiuqing, additional, Hall, Ira M., additional, Heard-Costa, Nancy L., additional, Heckbert, Susan R., additional, Heintz, Nicholas, additional, Herrington, David M., additional, Hickson, DeMarc, additional, Huang, Jie, additional, Hwang, Shih-Jen, additional, Jacobs, David R., additional, Jenny, Nancy S., additional, Johnson, Andrew D., additional, Johnson, Craig W., additional, Kawut, Steven, additional, Kronmal, Richard, additional, Kurz, Raluca, additional, Lange, Leslie A., additional, Larson, Martin G., additional, Lawson, Mark, additional, Lewis, Cora E., additional, Li, Dalin, additional, Lin, Honghuang, additional, Liu, Chunyu, additional, Liu, Jiankang, additional, Liu, Kiang, additional, Liu, Xiaoming, additional, Liu, Yongmei, additional, Longstreth, William T., additional, Loria, Cay, additional, Lunetta, Kathryn, additional, Mackey, Aaron J., additional, Mackey, Rachel, additional, Manichaikul, Ani, additional, Maxwell, Taylor, additional, McKnight, Barbara, additional, Meigs, James B., additional, Morrison, Alanna C., additional, Musani, Solomon K., additional, Mychaleckyj, Josyf C., additional, Nettleton, Jennifer A., additional, North, Kari, additional, O’Leary, Daniel, additional, Ong, Frank, additional, Palmas, Walter, additional, Pankow, James S., additional, Pankratz, Nathan D., additional, Paul, Shom, additional, Perez, Marco, additional, Person, Sharina D., additional, Polak, Joseph, additional, Quinlan, Aaron R., additional, Raffel, Leslie J., additional, Ramachandran, Vasan S., additional, Rice, Kenneth, additional, Sanders, Jill P., additional, Schreiner, Pamela, additional, Seshadri, Sudha, additional, Shea, Steve, additional, Sidney, Stephen, additional, Silverstein, Kevin, additional, Smith, Nicholas L., additional, Sotoodehnia, Nona, additional, Srinivasan, Asoke, additional, Taylor, Kent, additional, Thomas, Fridtjof, additional, Tsai, Michael Y., additional, Volcik, Kelly A., additional, Wassel, Chrstina L., additional, Watson, Karol, additional, Wei, Gina, additional, White, Wendy, additional, Wiggins, Kerri L., additional, Wilk, Jemma B., additional, Williams, O. Dale, additional, Wilson, Gregory, additional, Wolf, Phillip, additional, Zakai, Neil A., additional, Hardy, John, additional, Meschia, James F., additional, Nalls, Michael, additional, Singleton, Andrew, additional, Worrall, Brad, additional, Bamshad, Michael J., additional, Barnes, Kathleen C., additional, Abdulhamid, Ibrahim, additional, Accurso, Frank, additional, Anbar, Ran, additional, Beaty, Terri, additional, Bigham, Abigail, additional, Black, Phillip, additional, Bleecker, Eugene, additional, Buckingham, Kati, additional, Cairns, Anne Marie, additional, Caplan, Daniel, additional, Chatfield, Barbara, additional, Chidekel, Aaron, additional, Cho, Michael, additional, Christiani, David C., additional, Crapo, James D., additional, Crouch, Julia, additional, Daley, Denise, additional, Dang, Anthony, additional, Dang, Hong, additional, De Paula, Alicia, additional, DeCelie-Germana, Joan, additional, Drumm, Allen DozorMitch, additional, Dyson, Maynard, additional, Emerson, Julia, additional, Emond, Mary J., additional, Ferkol, Thomas, additional, Fink, Robert, additional, Foster, Cassandra, additional, Froh, Deborah, additional, Gao, Li, additional, Gershan, William, additional, Gibson, Ronald L., additional, Godwin, Elizabeth, additional, Gondor, Magdalen, additional, Gutierrez, Hector, additional, Hansel, Nadia N., additional, Hassoun, Paul M., additional, Hiatt, Peter, additional, Hokanson, John E., additional, Howenstine, Michelle, additional, Hummer, Laura K., additional, Kanga, Jamshed, additional, Kim, Yoonhee, additional, Knowles, Michael R., additional, Konstan, Michael, additional, Lahiri, Thomas, additional, Laird, Nan, additional, Lange, Christoph, additional, Lin, Lin, additional, Lin, Xihong, additional, Louie, Tin L., additional, Lynch, David, additional, Make, Barry, additional, Martin, Thomas R., additional, Mathai, Steve C., additional, Mathias, Rasika A., additional, McNamara, John, additional, McNamara, Sharon, additional, Meyers, Deborah, additional, Millard, Susan, additional, Mogayzel, Peter, additional, Moss, Richard, additional, Murray, Tanda, additional, Nielson, Dennis, additional, Noyes, Blakeslee, additional, O’Neal, Wanda, additional, Orenstein, David, additional, O’Sullivan, Brian, additional, Pace, Rhonda, additional, Pare, Peter, additional, Parker, H. Worth, additional, Passero, Mary Ann, additional, Perkett, Elizabeth, additional, Prestridge, Adrienne, additional, Rafaels, Nicholas M., additional, Ramsey, Bonnie, additional, Regan, Elizabeth, additional, Ren, Clement, additional, Retsch-Bogart, George, additional, Rock, Michael, additional, Rosen, Antony, additional, Rosenfeld, Margaret, additional, Ruczinski, Ingo, additional, Sanford, Andrew, additional, Schaeffer, David, additional, Sell, Cindy, additional, Sheehan, Daniel, additional, Silverman, Edwin K., additional, Sin, Don, additional, Spencer, Terry, additional, Stonebraker, Jackie, additional, Tabor, Holly K., additional, Varlotta, Laurie, additional, Vergara, Candelaria I., additional, Weiss, Robert, additional, Wigley, Fred, additional, Wise, Robert A., additional, Wright, Fred A., additional, Wurfel, Mark M., additional, Zanni, Robert, additional, Zou, Fei, additional, Green, Phil, additional, Shendure, Jay, additional, Akey, Joshua M., additional, Bustamante, Carlos D., additional, Eichler, Evan E., additional, Fox, P. Keolu, additional, Fu, Wenqing, additional, Gordon, Adam, additional, Gravel, Simon, additional, Johnsen, Jill M., additional, Kan, Mengyuan, additional, Kenny, Eimear E., additional, Kidd, Jeffrey M., additional, Lara-Garduno, Fremiet, additional, Leal, Suzanne M., additional, Liu, Dajiang J., additional, McGee, Sean, additional, O’Connor, Timothy D., additional, Paeper, Bryan, additional, Robertson, Peggy D., additional, Staples, Jeffrey C., additional, Tennessen, Jacob A., additional, Wang, Gao, additional, Yi, Qian, additional, Jackson, Rebecca, additional, Anderson, Garnet, additional, Anton-Culver, Hoda, additional, Auer, Paul L., additional, Beresford, Shirley, additional, Black, Henry, additional, Brunner, Robert, additional, Brzyski, Robert, additional, Burwen, Dale, additional, Caan, Bette, additional, Carty, Cara L., additional, Chlebowski, Rowan, additional, Cummings, Steven, additional, Curb, J. David, additional, Eaton, Charles B., additional, Ford, Leslie, additional, Fullerton, Stephanie M., additional, Gass, Margery, additional, Geller, Nancy, additional, Heiss, Gerardo, additional, Howard, Barbara V., additional, Hsu, Li, additional, Hutter, Carolyn M., additional, Ioannidis, John, additional, Johnson, Karen C., additional, Kuller, Lewis, additional, LaCroix, Andrea, additional, Lakshminarayan, Kamakshi, additional, Lane, Dorothy, additional, Lasser, Norman, additional, LeBlanc, Erin, additional, Li, Kuo-Ping, additional, Limacher, Marian, additional, Logsdon, Benjamin A., additional, Ludlam, Shari, additional, Manson, JoAnn E., additional, Margolis, Karen, additional, Martin, Lisa, additional, McGowan, Joan, additional, Monda, Keri L., additional, Kotchen, Jane Morley, additional, Nathan, Lauren, additional, Ockene, Judith, additional, O’Sullivan, Mary Jo, additional, Phillips, Lawrence S., additional, Prentice, Ross L., additional, Robbins, John, additional, Rossouw, Jacques E., additional, Sangi-Haghpeykar, Haleh, additional, Sarto, Gloria E., additional, Shumaker, Sally, additional, Simon, Michael S., additional, Stefanick, Marcia L., additional, Stein, Evan, additional, Tang, Hua, additional, Taylor, Kira C., additional, Thomson, Cynthia A., additional, Thornton, Timothy A., additional, Van Horn, Linda, additional, Vitolins, Mara, additional, Wactawski-Wende, Jean, additional, Wallace, Robert, additional, Wassertheil-Smoller, Sylvia, additional, Zeng, Donglin, additional, Applebaum-Bowden, Deborah, additional, Feolo, Michael, additional, Gan, Weiniu, additional, Paltoo, Dina N., additional, Sholinsky, Phyliss, additional, and Sturcke, Anne, additional

Published
2014
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35. Non-Hodgkin Lymphoma Risk and Variants in Genes Controlling Lymphocyte Development

Author

Schuetz, Johanna M., primary, Daley, Denise, additional, Leach, Stephen, additional, Conde, Lucia, additional, Berry, Brian R., additional, Gallagher, Richard P., additional, Connors, Joseph M., additional, Gascoyne, Randy D., additional, Bracci, Paige M., additional, Skibola, Christine F., additional, Spinelli, John J., additional, and Brooks-Wilson, Angela R, additional

Published
2013
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36. HLA-DQB1*02 and DQB1*06:03P are associated with peanut allergy

Author

Madore, Anne-Marie, primary, Vaillancourt, Vanessa T, additional, Asai, Yuka, additional, Alizadehfar, Reza, additional, Ben-Shoshan, Moshe, additional, Michel, Deborah L, additional, Kozyrskyj, Anita L, additional, Becker, Allan, additional, Chan-Yeung, Moira, additional, Clarke, Ann E, additional, Hull, Peter, additional, Daley, Denise, additional, Sandford, Andrew J, additional, and Laprise, Catherine, additional

Published
2013
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37. Correction: Lung eQTLs to Help Reveal the Molecular Underpinnings of Asthma

Author

Hao, Ke, primary, Bossé, Yohan, additional, Nickle, David C., additional, Paré, Peter D., additional, Postma, Dirkje S., additional, Laviolette, Michel, additional, Sandford, Andrew, additional, Hackett, Tillie L., additional, Daley, Denise, additional, Hogg, James C., additional, Elliott, W. Mark, additional, Couture, Christian, additional, Lamontagne, Maxime, additional, Brandsma, Corry-Anke, additional, van den Berge, Maarten, additional, Koppelman, Gerard, additional, Reicin, Alise S., additional, Nicholson, Donald W., additional, Malkov, Vladislav, additional, Derry, Jonathan M., additional, Suver, Christine, additional, Tsou, Jeffrey A., additional, Kulkarni, Amit, additional, Zhang, Chunsheng, additional, Vessey, Rupert, additional, Opiteck, Greg J., additional, Curtis, Sean P., additional, Timens, Wim, additional, and Sin, Don D., additional

Published
2012
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38. Lung eQTLs to Help Reveal the Molecular Underpinnings of Asthma

Author

Hao, Ke, primary, Bossé, Yohan, additional, Nickle, David C., additional, Paré, Peter D., additional, Postma, Dirkje S., additional, Laviolette, Michel, additional, Sandford, Andrew, additional, Hackett, Tillie L., additional, Daley, Denise, additional, Hogg, James C., additional, Elliott, W. Mark, additional, Couture, Christian, additional, Lamontagne, Maxime, additional, Brandsma, Corry-Anke, additional, van den Berge, Maarten, additional, Koppelman, Gerard, additional, Reicin, Alise S., additional, Nicholson, Donald W., additional, Malkov, Vladislav, additional, Derry, Jonathan M., additional, Suver, Christine, additional, Tsou, Jeffrey A., additional, Kulkarni, Amit, additional, Zhang, Chunsheng, additional, Vessey, Rupert, additional, Opiteck, Greg J., additional, Curtis, Sean P., additional, Timens, Wim, additional, and Sin, Don D., additional

Published
2012
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39. Genome-wide study identifies two loci associated with lung function decline in mild to moderate COPD

Author

Hansel, Nadia N., primary, Ruczinski, Ingo, additional, Rafaels, Nicholas, additional, Sin, Don D., additional, Daley, Denise, additional, Malinina, Alla, additional, Huang, Lili, additional, Sandford, Andrew, additional, Murray, Tanda, additional, Kim, Yoonhee, additional, Vergara, Candelaria, additional, Heckbert, Susan R., additional, Psaty, Bruce M., additional, Li, Guo, additional, Elliott, W. Mark, additional, Aminuddin, Farzian, additional, Dupuis, Josée, additional, O’Connor, George T., additional, Doheny, Kimberly, additional, Scott, Alan F., additional, Boezen, H. Marike, additional, Postma, Dirkje S., additional, Smolonska, Joanna, additional, Zanen, Pieter, additional, Mohamed Hoesein, Firdaus A., additional, de Koning, Harry J., additional, Crystal, Ronald G., additional, Tanaka, Toshiko, additional, Ferrucci, Luigi, additional, Silverman, Edwin, additional, Wan, Emily, additional, Vestbo, Jorgen, additional, Lomas, David A., additional, Connett, John, additional, Wise, Robert A., additional, Neptune, Enid R., additional, Mathias, Rasika A., additional, Paré, Peter D., additional, Beaty, Terri H., additional, and Barnes, Kathleen C., additional

Published
2012
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43. Asthma and genes encoding components of the vitamin D pathway

Author

Bossé, Yohan, primary, Lemire, Mathieu, additional, Poon, Audrey H, additional, Daley, Denise, additional, He, Jian-Qing, additional, Sandford, Andrew, additional, White, John H, additional, James, Alan L, additional, Musk, William Arthur, additional, Palmer, Lyle J, additional, Raby, Benjamin A, additional, Weiss, Scott T, additional, Kozyrskyj, Anita L, additional, Becker, Allan, additional, Hudson, Thomas J, additional, and Laprise, Catherine, additional

Published
2009
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47. The Relationship between Telomere Length and Mortality in Chronic Obstructive Pulmonary Disease (COPD).

Author

Jee Lee, Sandford, Andrew J., Connett, John E., Jin Yan, Tammy Mui, Yuexin Li, Daley, Denise, Anthonisen, Nicholas R., Brooks-Wilson, Angela, Man, S. F. Paul, and Sin, Don D.

Subjects
OBSTRUCTIVE lung diseases, AGING, CANCER, POLYMERASE chain reaction, LEUCOCYTES, TELOMERES
Abstract

Some have suggested that chronic obstructive pulmonary disease (COPD) is a disease of accelerated aging. Aging is characterized by shortening of telomeres. The relationship of telomere length to important clinical outcomes such as mortality, disease progression and cancer in COPD is unknown. Using quantitative polymerase chain reaction (qPCR), we measured telomere length of peripheral leukocytes in 4,271 subjects with mild to moderate COPD who participated in the Lung Health Study (LHS). The subjects were followed for approximately 7.5 years during which time their vital status, FEV1 and smoking status were ascertained. Using multiple regression methods, we determined the relationship of telomere length to cancer and total mortality in these subjects. We also measured telomere length in healthy "mid-life" volunteers and patients with more severe COPD. The LHS subjects had significantly shorter telomeres than those of healthy "mid-life" volunteers (p<.001). Compared to individuals in the 4th quartile of relative telomere length (i.e. longest telomere group), the remaining participants had significantly higher risk of cancer mortality (Hazard ratio, HR, 1.48; p = 0.0324) and total mortality (HR, 1.29; p = 0.0425). Smoking status did not make a significant difference in peripheral blood cells telomere length. In conclusion, COPD patients have short leukocyte telomeres, which are in turn associated increased risk of total and cancer mortality. Accelerated aging is of particular relevance to cancer mortality in COPD. [ABSTRACT FROM AUTHOR]

Published
2012
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48. Lung eQTLs to Help Reveal the Molecular Underpinnings of Asthma.

Author

Ke Hao, Bossé, Yohan, Nickle, David C., Paré, Peter D., Postma, Dirkje S., Laviolette, Michel, Sandford, Andrew, Hackett, Tillie L., Daley, Denise, Hogg, James C., Elliott, W. Mark, Couture, Christian, Lamontagne, Maxime, Brandsma, Corry-Anke, van den Berge, Maarten, Koppelman, Gerard, Reicin, Alise S., Nicholson, Donald W., Malkov, Vladislav, and Derry, Jonathan M.

Abstract

Genome-wide association studies (GWAS) have identified loci reproducibly associated with pulmonary diseases; however, the molecular mechanism underlying these associations are largely unknown. The objectives of this study were to discover genetic variants affecting gene expression in human lung tissue, to refine susceptibility loci for asthma identified in GWAS studies, and to use the genetics of gene expression and network analyses to find key molecular drivers of asthma. We performed a genome-wide search for expression quantitative trait loci (eQTL) in 1,111 human lung samples. The lung eQTL dataset was then used to inform asthma genetic studies reported in the literature. The top ranked lung eQTLs were integrated with the GWAS on asthma reported by the GABRIEL consortium to generate a Bayesian gene expression network for discovery of novel molecular pathways underpinning asthma. We detected 17,178 cis- and 593 trans- lung eQTLs, which can be used to explore the functional consequences of loci associated with lung diseases and traits. Some strong eQTLs are also asthma susceptibility loci. For example, rs3859192 on chr17q21 is robustly associated with the mRNA levels of GSDMA (P = 3.55610-151). The genetic-gene expression network identified the SOCS3 pathway as one of the key drivers of asthma. The eQTLs and gene networks identified in this study are powerful tools for elucidating the causal mechanisms underlying pulmonary disease. This data resource offers much-needed support to pinpoint the causal genes and characterize the molecular function of gene variants associated with lung diseases. [ABSTRACT FROM AUTHOR]

Published
2012
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49. Interaction of gender and body mass index (BMI) reveals evidence of linkage for hypertension in the Framingham Heart Study.

Author

Daley, Denise, Edwards, Shannon R., Yeunjoo Song, Baechle, Dan, Puppala, Sobha, Schick, J. H., Olson, Jane M., and Goddard, Katrina A. B.

Subjects
*BODY mass index, *HYPERTENSION, *GENETIC research, *GENETIC engineering
Abstract

Background: Genetic heterogeneity and complex biologic mechanisms of blood pressure regulation pose significant challenges to the identification of susceptibility loci influencing hypertension. Previous linkage studies have reported regions of interest, but lack consistency across studies. Incorporation of covariates, in particular the interaction between two independent risk factors (gender and BMI) greatly improved our ability to detect linkage. Results: We report a highly significant signal for linkage to chromosome 2p, a region that has been implicated in previous linkage studies, along with several suggestive linkage regions. Conclusion: We demonstrate the importance of including covariates in the linkage analysis when the phenotype is complex. [ABSTRACT FROM AUTHOR]

Published
2003
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50. Is TGFBR1*6A a Susceptibility Allele for Nonsyndromic Familial Colorectal Neoplasia?

Author

Daley, Denise, Morgan, Wendi, Lewis, Susan, Willis, Joseph, Elston, Robert C., Markowitz, Sanford D., and Wiesner, Georgia L.

Abstract

The article analyzes the link between type I transforming growth factor-β receptor (TGFRB1*6A) allele and colorectal neoplasia based on a study. Researchers genotyped 53 kindreds with colon cancer or advanced colon adenomas. The use of Haseman-Elston regression analysis in the study is described. The researchers conclude that TGFRB1*6A can be excluded as a susceptibility allele at the nearby linked locus found on chromosome 9.

Published
2007
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