Search

Your search keyword '"Dai, Weigang"' showing total 23 results
Start Over Author "Dai, Weigang" Search Limiters Full Text
23 results on '"Dai, Weigang"'

3. Gingerenone A Attenuates Ulcerative Colitis via Targeting IL‐17RA to Inhibit Inflammation and Restore Intestinal Barrier Function.

Author

Liang, Jian, Dai, Weigang, Liu, Chuanghui, Wen, Yifan, Chen, Chen, Xu, Yifei, Huang, Song, Hou, Shaozhen, Li, Chun, Chen, Yongming, Wang, Wei, and Tang, Hailin

Subjects
*INTESTINAL barrier function, *ULCERATIVE colitis, *SURFACE plasmon resonance, *INFLAMMATION, *MOLECULAR dynamics
Abstract

Ulcerative colitis (UC) is a complicated and recurrent intestinal disease. Currently available drugs for UC treatment are scarce, therefore, novel therapeutic drugs for the UC are urgently to be developed. Gingerenone A (GA) is a phenolic compound known for its anti‐inflammatory effect, but its effect on UC remains unknown. Here, it is shown that GA protects mice against UC, which is closely associated with inhibiting intestinal mucosal inflammation and enhancing intestinal barrier integrity in vivo and in vitro. Of note, RNA sequencing analysis demonstrates an evident correlation with IL‐17 signaling pathway after GA treatment, and this effect is further corroborated by Western blot. Mechanistically, GA directly interacts with IL‐17RA protein through pull‐down, surface plasmon resonance analysis and molecular dynamics simulation. Importantly, lentivirus‐mediated IL‐17RA/Act1 knock‐down or GA co‐treatment with brodalumab/ixekizumab significantly impairs the protective effects of GA against DSS‐induced inflammation and barrier dysfunction, suggesting a critical role of IL‐17RA signaling for GA‐mediated protection against UC. Overall, these results indicate that GA is an effective agent against UC mainly through the direct binding of IL‐17RA to inhibit inflammatory signaling activation. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

8. Systemic immune-inflammation index (SII): A More Promising Inflammation-Based Prognostic Marker for Patients with synchronic colorectal peritoneal carcinomatosis

Author

Dai Weigang, Chen Jianhui, Chen Chuangqi, Zhang Zhimei, Peng Jianjun, Zhai Ertao, and Qian Yan

Subjects
Oncology, medicine.medical_specialty, Multivariate analysis, medicine.medical_treatment, Inflammation, 03 medical and health sciences, 0302 clinical medicine, neutrophil-to-lymphocyte ratio, Internal medicine, systemic immune-inflammation index, medicine, Synchronic colorectal peritoneal carcinomatosis, Neutrophil to lymphocyte ratio, Survival analysis, Univariate analysis, Chemotherapy, Proportional hazards model, business.industry, Nomogram, platelet-to-lymphocyte ratio, prognosis, 030220 oncology & carcinogenesis, 030211 gastroenterology & hepatology, medicine.symptom, business, Research Paper
Abstract

Objective: Synchronic colorectal peritoneal carcinomatosis (SCRPC) was recognized as a predictor of poor prognosis. The aim of this study was to investigate the role of neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and systemic immune-inflammation index (SII) on the survival outcome, which might help determine the treatment management of SCRPC patients. Methods: A total of 103 SCRPC patients following cytoreduction surgery (CRS) and systematic chemotherapy (CT) between 1997 and 2013 in the First Affiliated Hospital of Sun Yat-sen University were retrospectively analyzed. The comparison of the clinicopathological variables and systematic inflammatory biomarkers, including NLR, PLR and SII, was performed by Chi-test and Cox regression analysis. According to the results of multivariate analysis, a prognostic nomogram was generated, and its prediction ability was measured by the concordance index (C-index). The survival curves were generated using the Kaplan-Meier method and survival comparison between groups was conducted via the log-rank test. Results: Univariate analysis revealed that elevated NLR, PLR and SII were significantly correlate with worse survival outcome. Only low SII value was recognized as an independent favorable prognostic factor for overall survival (HR=1.772, 95% CI=1.015-3.095, P=0.044), except for NLR and PLR. The nomogram could perform well in the prediction of overall survival in SCRPC patients (c-index 0.782). Moreover, SII had strong prognostic discriminatory ability to predict survival outcome for the patients receiving completeness of cytoreduction score (CCR) 0/1 or CCR2/3, rather than NLR and PLR. Conclusions: SII was a better inflammation factor to predict the outcomes of SCRPC patients receiving CRS and systematic CT. Low SII value was the most favorable factor benefiting from different level of CRS and it was useful for determining the appropriate treatment strategy for SCRPC patients.

Published
2020

10. Designing a castor oil-based polyurethane as bioadhesive

Author

Zhang Yanhong, Su Qiulan, Wei Dan, Xia Zhengbin, and Dai Weigang

Subjects
Castor Oil, Materials science, Surface Properties, Bioadhesive, Polyurethanes, Biocompatible Materials, 02 engineering and technology, 01 natural sciences, chemistry.chemical_compound, Colloid and Surface Chemistry, Differential scanning calorimetry, Materials Testing, 0103 physical sciences, medicine, Particle Size, Physical and Theoretical Chemistry, Composite material, Curing (chemistry), Polyurethane, Universal testing machine, 010304 chemical physics, Temperature, Adhesiveness, Surfaces and Interfaces, General Medicine, 021001 nanoscience & nanotechnology, chemistry, Castor oil, Adhesive, 0210 nano-technology, Ethylene glycol, Biotechnology, medicine.drug
Abstract

Based on the stealth behavior of castor oil and poly(ethylene glycol), we selected a polyurethane system to obtain an ideal surgical adhesive. The polyurethane adhesives with varying concentrations of castor oil were investigated by Fourier transform infrared spectrometer, differential scanning calorimetry, scanning electron microscopy, goniometer, and universal testing machine. Curing results show that a 7-min to 25-min room temperature curing can be achieved, providing one possibility of shortening the surgery time. In vitro biodegradation test demonstrates that a certain proportion of the polyurethane film will be hydrolyzed in a foregone manner after a period of time (7 weeks). The adhesion strengths of these adhesives show a strong bonding between pieces of tissue, which makes them qualified for application in a moist environment.

Published
2019
Full Text
View/download PDF

14. Elevated expression of CXCL16 correlates with poor prognosis in patients with colorectal cancer

Author

Chen,Zhihui, Dai,Weigang, Yang,Liang, Yang,Hong, Ding,Li, He,Yulong, Song,Xinming, and Cui,Ji

Subjects
Cancer Management and Research
Abstract

Zhihui Chen,1,* Weigang Dai,1,* Liang Yang,1,* Hong Yang,2 Li Ding,3 Yulong He,1 Xinming Song,1 Ji Cui11Department of Gastrointestinal Surgery Center, First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, People’s Republic of China; 2Operating Department, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, People’s Republic of China; 3Department of Pathology, First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, People’s Republic of China*These authors contributed equally to this workAims: To examine the expression of CXCL16 in colorectal cancer (CRC) tissue and to clarify the relationships between CXCL16 and clinicopathological features and survival in CRC.Methods: A total of 142 consecutive CRC patients undergoing colorectal surgery at the Department of Gastrointestinal Center, First Affiliated Hospital, Sun Yat-sen University, between January 2010 and December 2010 were enrolled in this study. CXCL16 was measured by immunohistochemical staining in CRC tissue. Association between CXCL16 expression and clinicopathologic parameters was analyzed with a chi-square test. Survival curves were calculated by the Kaplan–Meier method, and the differences between CXCL16 high- and low-expression groups were analyzed using the log-rank test. Cox univariate and multivariate analyses were used to determine risk factors for overall survival (OS).Results: CXCL16 expression was elevated in CRC. CXCL16-positive expression was significantly related to tumor size (P=0.043), tumor differentiation (P=0.046) and distant metastasis (P=0.038), and there was a trend toward lymph node metastasis (P=0.070). CXCL16 expression, together with differentiation, depth of invasion, lymph node metastasis, and distant metastasis, was a significant independent prognostic factor for OS of patients with CRC (HR 2.026, 95% CI 1.128–3.640, P=0.018).Conclusion: CXCL16 expression was enhanced in CRC tissue and was negatively correlated with survival in CRC patients. Furthermore, CXCL16-positive expression was an independent prognostic factor for CRC patients, whilst the underlying mechanisms remain unclear; thus, further studies are needed.Keywords: colorectal neoplasms, chemokine, CXCL16, prognosis

Published
2019

22. Two cases of small bowel obstruction due to a shiitake mushroom.

Author

Tan, Jinfu, Yuan, Kaitao, Zuo, Jidong, Dai, Weigang, Yuan, Yujie, Feng, Weidong, Tan, Min, and Ma, Jinping

Subjects
BOWEL obstructions, EDIBLE mushrooms, ABDOMINAL surgery
Abstract

The shiitake mushroom (Lentinula edodes), known as Xiang-gu in China, has been an important component of Asian cuisine for hundreds of years. Although not easily digestible, there are few reports of them causing bowel obstruction. We present two cases of small bowel obstruction due to a shiitake mushroom requiring surgical intervention. Two patients who did not have any teeth and did not use dentures presented with intestinal bowel obstruction and were referred to the Emergency Department of our hospital after eating a meal including shiitake mushrooms without cutting. The first patient underwent an emergency laparotomy and a semental small bowel resection and the other underwent laparoscopic small bowel incision for removal of a foreign body. The causes of the small bowel obstruction for the two patients were uncut shiitake mushrooms in the small bowel. The two patients recovered uneventfully post-operatively. [ABSTRACT FROM AUTHOR]

Published
2019
Full Text
View/download PDF

23. Metastatic tumor of male genital system from gastric cancer: a case report and review of literature.

Author

Dai W, Liu D, Zuo J, Tan J, Wang L, Wu H, Cai S, and Yuan Y

Abstract

Spermatic cord (SC) tumor metastatic from gastric cancer (GC) is rare. Here we report a case of left SC metastasis and meanwhile perform a literature review to characterize this rare disease. A 72-year-old male presented with a palpable painful mass in the left groin after one year and a half of remnant GC resection. SC metastasis of signet-ring cell adenocarcinoma was confirmed by trans-inguinal biopsy, and palliative chemoradiotherapy was initiated. The disease remained stable within follow-up 10 months. A total of 27 GC patients with male sex cord metastasis were reviewed according to a literature search from January 1955 to March 2016. In such a cohort, the mean age was 58.3 (range, 23-72) years. The average time interval between primary GC and genital metastasis was 43.2 (range, 2-120) months in 16 (59.3%) metachronous cases, while nine (33.3%) synchronous cases reported. The average size of genital tumor was 3.8 (range, 2.1-9.0) cm in diameter. The major pathological characteristics were signet-ring cell (40.0%, 8/20) and poor differentiation (85.0%, 17/20), with right-side sex cord most commonly involved (48.1%). The incidence of genial metastasis was 74.1% in SC, with 40.7% for epididymis, 33.3% for testis, 14.8% for tunica vaginalis and 3.7% for scrotum. The one-year overall survival rate was 38.7%, with a median survival time of 12 months. Advanced GC metastatic to male sex cord is rare, with poor prognosis. For patients with GC history and groin discomfort or mass, metastatic adenocarcinoma should be suspected, followed by proper diagnosis and treatment., Competing Interests: None., (IJCEP Copyright © 2017.)

Published
2017

Catalog

Books, media, physical & digital resources
See catalog results