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Oxaliplatin is a first-line clinical drug in cancer treatment and its side effects of peripheral neuropathic pain have also attracted much attention. Neuroinflammation induced by oxidative stress-mediated activation of nuclear factor-kappa B (NF-κB) plays an important role in the course. Current studies have shown that curcumin has various biological activities like antioxidant, anti-inflammatory, antitumor and so on, while few studies were conducted about its role in oxaliplatin-induced peripheral neuropathic pain. The aim of this study is to verify the mechanism of curcumin alleviating oxaliplatin-induced peripheral neuropathic pain. Intraperitoneal injection with oxaliplatin (4 mg/kg body weight) was given to the rats twice a week and last for four weeks to establish the model rats. Gavage administration of curcumin (12.5, 25, and 50 mg/kg body weight, respectively) was conducted for consecutive 28 d to explore the effects and potential mechanism. Our results showed that curcumin administration could increase mechanical withdrawal threshold and decrease the paw-withdrawal times of cold allodynia significantly; meanwhile, motor nerve conduction velocity (MNCV) and sense nerve conduction velocity (SNCV) were both increased and the injured neurons of the spinal cord were repaired. In addition, curcumin administration increased superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), catalase (CAT) and reduced malondialdehyde (MDA). Moreover, the curcumin operation inhibited the activated of NF-κB and level of inflammatory factors like tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β) and interleukin-6 (IL-6). In conclusion, these findings suggested that curcumin could alleviate oxaliplatin-induced peripheral neuropathic pain; the mechanism might be inhibiting oxidative stress-mediated activation of NF-κB and mitigating neuroinflammation.

For mass surveillance, the algorithm substitution attacks (ASAs) are serious security threats to the symmetric encryption schemes. At CRYPTO 2014, Bellare, Paterson, and Rogaway (BPR) formally developed the security notions of decryptability, undetectability, and surveillance and presented a unique ciphertext symmetric encryption scheme against all possible ASAs. At FSE 2015, Degabriele, Farshim, and Poettering (DFP) relaxed the correctness of decryptability and presented an input-triggered ASA, which meets the BPR security definitions but violates the security of the BPR unique ciphertext scheme. Hence, DFP refined the security notions of detectability and subversion resistance to remove their ASA from the BPR unique ciphertext scheme. At CCS 2015, Bellare, Jaeger, and Kane (BJK) also developed the security notion of key recovery to make the input-triggered ASA infeasible. We investigate ASAs on the symmetric encryption scheme. Our contribution is twofold. (1) We propose a new trigger ASA against the symmetric encryption scheme . Our proposed ASA cannot be captured by the BJK security definitions. Comparatively, the DFP security definitions can detect our proposed ASA. In the view of ASAs, this result demonstrates that the DFP security definitions are not identical to the BJK security definitions. (2) We improve the DFP definition of subversion resistance . DFP proved that the BPR unique ciphertext scheme defeats the input-triggered ASA under their subversion resistance definition. However, we show that the BPR unique ciphertext scheme fails to meet the DFP subversion resistance definition due to our proposed ASA. Therefore, an improved definition on subversion resistance is proposed to cover all existing trigger ASAs. We prove that the BPR unique ciphertext scheme is secure under our improved definition. Therefore, we believe that our improved definition is more suitable to evaluate the ASA security of the symmetric encryption scheme.

Session Initiation Protocol (SIP) is the most widely used signalling protocol for controlling communication, establishing, maintaining, and terminating sessions on the Internet. However, since sensitive information is often transmitted through open channels, a security authentication scheme is essential. Recently, Islam et al. proposed an authentication scheme for SIP, and argued that the scheme is immune to known attacks. However, we discover that their scheme fails to achieve user anonymity, and it cannot even resist impersonation attack. Therefore, this study proposes an enhanced mutual authentication scheme to eliminate the drawbacks of the scheme proposed by Islam et al. In addition, our proposed scheme is based on extended chaotic map, which avoids computationally expensive elliptic curve point multiplication. Then, we use Burrows-Abadi-Needham logic to prove that the proposed scheme achieves secure mutual authentication, and we use the Real-Or-Random model to analyze the formal security verification of the session key. Finally, we compare the performance and the security features of the proposed scheme with some existing schemes. Therefore, we provide better safety and efficiency than related schemes and the proposed scheme is suitable for SIP.

The advanced encryption standard (AES) is the most encryption algorithm used around the world. This fact made it coveted by several cryptanalysis attacks. Some of them succeed to reveal certain weakness, due to its static parameters known by the public mass. The substitution box (S-Box) is among the most sensitive parameters of this standard, which plays a crucial role in the protection against these attacks. In this study, a new version of AES is introduced, which uses a set of AES-like S-Boxes instead of the original one. These S-Boxes, generated from different irreducible polynomials, are dynamically chosen, depending on the encryption key. This introduction is conducted by the design and the implementation of a new block cipher version of AES, based on a key dependent S-Box cube. Where a cube of six interchangeable S-Boxes key-dependently generated is constructed. This cube determines the active S-Box for a given round, through its random rotations guided by the round key. Furthermore, the improvement of the cryptographic robustness, provided by this method is demonstrated. This is accomplished through a comparison with the original AES, in terms of statistical and cryptographic randomness properties.

A basic but expensive operation in the implementations of several famous public-key cryptosystems is the computation of the multi-scalar multiplication in a certain finite additive group defined by an elliptic curve. We propose an adaptive window method for the multi-scalar multiplication, which aims to balance the computation cost and the memory cost under register-constrained environments. That is, our method can maximize the computation efficiency of multi-scalar multiplication according to any small, fixed number of registers provided by electronic devices. We further demonstrate that our method is efficient when five registers are available. Our method is further studied in detail in the case where it is combined with the non-adjacent form (NAF) representation and the joint sparse form (JSF) representation. One efficiency result is that our method with the proposed improved NAF n-bit representation on average requires 209n/432 point additions. To the best of our knowledge, this efficiency result is optimal compared with those of similar methods using five registers. Unlike the previous window methods, which store all possible values in the window, our method stores those with comparatively high probabilities to reduce the number of required registers.

As an open standard for the short-range radio frequency communications, Bluetooth is suitable for Mobile Crowdsensing Systems (MCS). However, the massive deployment of personal Bluetooth-enabled devices also raises privacy concerns on their wielders. Hence, we investigate the privacy of the unilateral authentication protocol according to the recent Bluetooth standard v5.2. The contributions of the paper are twofold. (1) We demonstrate that the unilateral authentication protocol suffers from privacy weakness. That is, the attacker is able to identify the target Bluetooth-enabled device once he observed the device’s previous transmitted messages during the protocol run. More importantly, we analyze the privacy threat of the Bluetooth MCS, when the attacker exploits the proposed privacy weakness under the typical Internet of Things (IoT) scenarios. (2) An improved unilateral authentication protocol is therefore devised to repair the weakness. Under our formal privacy model, the improved protocol provably solves the traceability problem of the original protocol in the Bluetooth standard. Additionally, the improved protocol can be easily adapted to the Bluetooth standards because it merely employs the basic cryptographic components available in the standard specifications. In addition, we also suggest and evaluate two countermeasures, which do not need to modify the original protocol.

Background/Aims. In previous studies, it has been observed that Xiaotan Jieyu (XTJY) prescription may inhibit the proliferation of human breast precancerous lesion MCF-10AT cells by inhibiting the PI3K/Akt signaling pathway. The purpose of this study is to further verify the therapeutic effect and the possible mechanism of XTJY on precancerous lesions of breast cancer in vivo. Methods. The successfully established breast precancerous lesion rat model and normal healthy rats were randomly assigned into the blank (BLA), model (MOD), XTJY-low (LD), XTJY-medium (MD), XTJY-high (HD), and tamoxifen (TAM) groups. Different concentrations of XTJY and saline were supplied by intragastric administration for 4 consecutive weeks to assess the protective effect of XTJY on the progress of the breast precancerous lesion in rats involving the phosphatidylinositol-3-kinase (PI3K)/protein kinase B (Akt) signaling pathway. Results. In this study, it determined that 10 mg/each rat DMBA-combined estrogen and progesterone induction for 10 weeks was the optimal condition for the establishment of the breast precancerous lesion rat model. In vivo administration of XTJY or TAM was found to inhibit the development of the breast precancerous lesion, and the occurrence rate of breast invasive carcinomas was decreased by about 50%. Furthermore, XTJY or TAM markedly reduced protein expressions of PI3K and p-Akt and increased protein expressions of PTEN. Conclusion. These data indicated that XTJY can significantly alleviate the development of breast precancerous lesions by inhibiting the activation of the PI3K/Akt signaling pathway. XTJY may be a promising drug for the treatment of precancerous lesions in breast cancer.

Objective To investigate the effcts of methylnitronitrosoguanidine (MNNG) on the malignant transformation of human gastric mucosa GES-1 cells and explore the possible molecular mechanism. Methods The GES-1 cells was treated by 9 different concentrations of MNNG for 24h, then removed MNNG and culture cell normally. The cell proliferation was detected by CCK-8 assay after 24h. The effects of MNNG on invasion and migration ability were detected by Transwell invasion and migration tests after 24h. The apoptosis was detected by Annexin V-FITC/PI FCM after 48h, and the expression levels of NF-κB p65 mRNA and protein were measured by real-time fluorescent quantitative PCR and Western blotting respectively. Results 2×10–4mol/L MNNG was chose for the induction of malignant transformation of GES -1 cells by the statistic analysis, 2×104mol/L MNNG could increase the proliferation, promote the invasion and migration, suppress the apoptosis of GES-1 cells (P

In this article, we introduce a new concept of oblivious transfer with membership verification that allows any legitimate group users to obtain services from a service provider in an oblivious manner. We present two oblivious transfer with membership verification schemes, differing in design. In the first scheme, a trusted group manager issues credentials for a pre-determined group of users so that the group of users with a valid group credential can obtain services from the service provider, while the choices made by group users remain oblivious to the service provider. The second scheme avoids the trusted group manager, which allows any user in the group to be a group manager, thus it is more suitable in distributed systems. In particular, we prove that the two oblivious transfer with membership verification schemes can achieve receiver’s privacy and sender’s privacy under a half-simulation model.

In recent years, Chinese medicine has played an important role in the prognosis of gastric cancer. Precancerous lesions of gastric carcinoma (PLGC) is a class of gastric cancer which is closely related to the gastric mucosal pathology changes in the role of carcinogenic incentives, and plays key role in the progression of normal gastric mucosal cells into gastric cancerous cells. In current experiment, we explore the relationship between Chinese traditional medicine (Xiao Tan He Wei Decoction) and gastric cancer in the PLGC rat animal models and epithelial-mesenchymal transitioned GES-1 cells which were induced useing 1- Methyl-3-nitro-1-nitrosoguanidine (MNNG). PLGC rat model showed significant deterioration in the gastric mucosa with terrible growth rate in body weight and more atypical hyperplasia in gastric mucosa. MC cells, MNNG induced GES-1 cells which epithelial- mesenchymal-transition (EMT)-related proteins have a great change compare with normal GES-1 cells. The cells had characteristics of malignant cells including proliferation, invasion and metastasis ability. Our research founds that Xiao Tan He Wei Decoction could inhibit cell proliferation and increased apoptosis by increase the level of pro-apoptotic proteins like Bax and caspase-3 and decreased the level of anti-apoptotic protein Bcl-2, block the cells in G0/G1 phase simultaneously. Furthermore, Xiao Tan He Wei Decoction could inhibit nuclear factor kappa-light-chain-enhancer (NF-kB) activity and inhibit its transfer from the cytoplasm to the nucleus. However, when we incubated with NF-κB activator PMA, the effect of Xiao Tan He Wei Decoction was reversed. These results suggested that Xiao Tan He Wei Decoction could be used as a method for the treatment of gastric precancerous lesions, and possibly provide a theoretical basis for the clinical treatment of gastric cancer and gastric precancerous lesions.

Bluetooth low energy devices are very popular in wireless personal area networks. According to the Bluetooth standard specifications, the low energy secure simple pairing (LESSP) protocol is the process by which the pairing devices negotiate the authenticated secret key. To violate the user privacy, the adversary can perhaps link the runs of the LESSP protocol to the targeted device, which usually relates to the specially appointed user. Hence, we investigate deep into the privacy of the LESSP protocol. Our main contributions are threefold: (1) We demonstrate that the LESSP protocol suffers from privacy vulnerability. That is, an adversary without any secret key is able to identify the targeted device by the LESSP protocol. (2) An improvement is therefore proposed to repair the privacy vulnerability in the LESSP protocol. (3) We develop a formal privacy model to evaluate the privacy vulnerabilities in the LESSP protocol and its improved versions. We further prove that our improvement on the LESSP protocol is private under the privacy model. In addition, the performance evaluation shows that our improvement is as efficient as the LESSP protocol. Our research results are beneficial to the privacy enhancement of Bluetooth systems in wireless personal area networks.

In 2009, Wu proposed a fast modular exponentiation algorithm and claimed that the proposed algorithm on average saved about 38.9% and 26.68% of single-precision multiplications as compared to Dusse-Kaliski's Montgomery algorithm and Ha-Moon's Montgomery algorithm, respectively. However, in this comment, we demonstrate that Wu's algorithm on average reduces the number of single-precision multiplications by at most 22.43% and 6.91%, when respectively compared with Dusse-Kaliski's version and Ha-Moon's version. That is, the computational efficiency of Wu's algorithm is obviously overestimated.

RFID (Radio Frequency Identification) tags are small, wireless electronic devices that help identify objects and people. Privacy protection and integrity assurance become rather crucial in the RFID systems, because these RFID tags may have a wide transmission range, making them subject to unauthorized scanning by malicious readers and various other attacks. Hence, Ha et al. proposed an RFID protocol and proved that their protocol can provide the forward privacy service. However, in this paper, it is shown that an attacker can track a target tag by observing unsuccessful previous session of the tag. That is, Ha et al.'s RFID protocol fails to provide the forward privacy protection as claimed. Therefore, to overcome the privacy weaknesses of Ha et al.'s RFID protocol, an RFID protocol based on the cryptographic hash functions is proposed. Moreover, the proposed RFID protocol is evaluated according to both the privacy attribute and the implementation performance.

New node deployment is inevitable in a wireless sensor network because nodes in the network may be lost, exhausted, or destroyed. To secure the new node deployment process, Kim and Lee (2009) proposed an enhanced novel access control protocol (ENACP) using the elliptic curve cryptography and the hash chain. We identified an inherent flaw in their design and demonstrated that ENACP is vulnerable to a new node masquerading attack and a legal node masquerading attack, in violation of their security claims. We hope that by identifying this design flaw, similar structural mistakes can be avoided in future designs. Refereed/Peer-reviewed

Figure 4 contained an error. "Diffie-Hellman key" in step 1c' of Figure 4 should be changed to "Diffie-Hellman keys". The original article was corrected.

In the IEEE TRANSACTIONS ON INDUSTRIAL ELECTRONICS, vol. 55, no. 6, Juang et al.proposed a password-authenticated key agreement scheme using smart cards. Although the scheme of Juang et al. has many benefits, we find that it suffers from three weaknesses: 1) inability of the password-changing operation; 2) the session-key problem; and 3) inefficiency of the double secret keys. Therefore, we propose an improved scheme to overcome the weaknesses and maintain the benefits of the original scheme. In addition, our improved scheme reduces the storage and computation costs on the smart card compared with the scheme of Juang et al. We believe that our improved scheme is more suitable for real-life applications than that of Juang et al.

Increasingly, today's mobile devices provide users a high level of convenience and flexibility. But, mobile devices are vulnerable to theft and loss, greatly increasing the likelihood of exposing sensitive data. To address this problem, Corner and Noble gave the concept of transient authentication and built a wearable token system, called ZIA system. In this paper, we design a new wearable token system using the idea of transient authentication. Our system not only preserves the same security characteristics as ZIA system, but also is more effective than ZIA system. In our system, careful key management and prudent communication mechanism allow significant performance enhancements. Due to the power constraint of the wearable token and the wireless link, the lower the costs are, the greater the chance of success the wearable token system has in practical implementation.

Very few solutions are known to protect the modular exponentiation for single-chip devices against simple power analysis (SPA) attacks. In this paper, we present a model approach to address the power analysis problem. Using the model approach, we propose a modular exponentiation algorithm, which is secure under the SPA model. Compared with the known solutions, the proposed algorithm is more suitable for real-life applications .

BACKGROUND: Increasing evidence indicated plasma D-dimer could be regarded as a marker in cancers, however, its role in gastric cancer is still largely unknown. METHODS: Plasma D-dimer levels were measured by enzyme linked fluorescent immunoassays and evaluated by receiver operating characteristic (ROC) curves for peritoneal dissemination in gastric cancer and healthy subjects. The overall survival (OS) characteristics were determined using Kaplan-Meier and Cox regression analyses. RESULTS: The average of the plasma D-dimer levels for gastric cancer patients was significantly higher than the healthy subjects. A Spearman correlation analysis showed that plasma D-dimer levels correlated with the depth of invasion, lymph node metastasis, peritoneal dissemination, distant metastasis, tumor size and TNM stage. The mean plasma D-dimer level was 2.20 ± 1.51 µg/mL in peritoneal dissemination patients and 1.01 ± 0.79 µg/mL in non-peritoneal dissemination patients (P

To explore advantages of Chinese medicine (CM) by analyzing differences in the origin of philosophy for human health between CM and Western medicine (WM). Methodologically, a distinctive feature of CM is its systems theory, which is also the difference between CM and WM. Since the birth of CM, it has taken the human body as a whole from the key concepts of "qi, blood, yin-yang, viscera (Zang-Fu), and meridian and channel", rather than a single cell or a particular organ. WM evolves from the Western philosophic way of thinking and merely uses natural sciences as the foundation. The development of WM is based on human structures, or anatomy, and therefore, research of WM is also based on the way of thinking of decomposing the whole human body into several independent parts, which is the impetus of promoting the development of WM. The core of CM includes the holistic view and the dialectical view. Chinese herbal medicines contain various components and treat a disease from multiple targets and links. Therefore, Chinese herbal medicines treat a diseased state by regulating and mobilizing the whole body rather than just regulating a single factor, since the diseased state is not only a problem in a local part of the body but a local reflection of imbalance of the whole body.

Introduction. Posttraumatic stress disorder (PTSD) is accompanied by poor general psychological status (GPS). In the present study, we investigated the effects of a Chinese herbal formula on GPS in earthquake survivors with PTSD.Methods. A randomized, double-blind, placebo-controlled trial compared a Chinese herbal formula,Xiao-Tan-Jie-Yu-Fang(XTJYF), to placebo in 2008 Sichuan earthquake survivors with PTSD. Patients were randomized into XTJYF (n=123) and placebo (n=122) groups. Baseline-to-end-point score changes in the three global indices of the Symptom Checklist-90-Revised (SCL-90-R) and rates of response in the SCL global severity index (GSI) were the primary endpoints. A subanalysis of the nine SCL factors and the sleep quality score were secondary endpoints.Results and Discussion. Compared to placebo, the XTJYF group was significantly improved in all three SCL global indices (P= 0.001~0.028). More patients in the XTJYF group reported “much improved” than the placebo group (P= 0.001). The XTJYF group performed significantly better than control in five out of nine SCL factors (somatization, obsessive-compulsive behavior, depression, anxiety, and hostility (P= 0.001~0.036)), and in sleep quality score (P<0.001). XTJYF produced no serious adverse events. These findings suggest that XTJYF may be an effective and safe treatment option for improving GPS in patients with PTSD.

AIM: To establish nude mouse human gastric cancer orthotopic transplantation models using OB glue paste technique. METHODS: Using OB glue paste technique, orthotopic transplantation models were established by implanting SGC-7901 and MKN-45 human gastric cancer cell strains into the gastric wall of nude mice. Biological features, growth of the implanted tumors, the success rate of transplantation and the rate of auto-metastasis of the two models were observed. RESULTS: The success rates of orthotopic transplan-tation of the two models were 94.20% and 96%. The rates of hepatic metastasis, pulmonary metastasis, peritoneal metastasis, lymphocytic metastasis and splenic metastasis were 42.13% and 94.20%, 48.43% and 57.97%, 30.83% and 36.96%, 67.30% and 84.06%, and 59.75% and 10.53%, respectively. The occurrence of ascites was 47.80% and 36.96%. CONCLUSION: OB glue paste technique is easy to follow. The biological behaviors of the nude mouse human gastric cancer orthotopic transplantation models established with this technique are similar to the natural processes of growth and metastasis of human gastric cancer, and, therefore, can be used as an ideal model for experimental research of proliferative metastasis of tumors.

AIM: To determine the underlying mechanisms of action and influence of Xiaotan Sanjie (XTSJ) decoction on gastric cancer stem-like cells (GCSCs). METHODS: The gastric cancer cell line MKN-45 line was selected and sorted by FACS using the cancer stem cell marker CD44; the stemness of these cells was checked in our previous study. In an in vitro study, the expression of Notch-1, Hes1, Vascular endothelial growth factor (VEGF), and Ki-67 in both CD44-positive gastric cancer stem-like cells (GCSCs) and CD44-negative cells was measured by Western blot. The effect of XTSJ serum on cell viability and on the above markers was measured by MTT assay and Western blot, respectively. In an in vivo study, the ability to induce angiogenesis and maintenance of GCSCs in CD44-positive-MKN-45- and CD44-negative-engrafted mice were detected by immunohistochemical staining using markers for CD34 and CD44, respectively. The role of XTSJ decoction in regulating the expression of Notch-1, Hes1, VEGF and Ki-67 was measured by Western blot and real-time polymerase chain reaction. RESULTS: CD44+ GCSCs showed more cell proliferation and VEGF secretion than CD44-negative cells in vitro, which were accompanied by the high expression of Notch-1 and Hes1 and positively associated with tumor growth (GCSCs vs CD44-negative cells, 2.72 ± 0.25 vs 1.46 ± 0.16, P < 0.05) and microvessel density (MVD) (GCSCs vs CD44-negative cells, 8.15 ± 0.42 vs 3.83 ± 0.49, P < 0.001) in vivo. XTSJ decoction inhibited the viability of both cell types in a dose-dependent manner in vitro. Specifically, a significant difference in the medium- (82.87% ± 6.53%) and high-dose XTSJ groups (77.43% ± 7.34%) was detected at 24 h in the CD44+ GCSCs group compared with the saline group (95.42% ± 5.76%) and the low-dose XTSJ group (90.74% ± 6.57%) (P < 0.05). However, the efficacy of XTSJ decoction was reduced in the CD44- groups; significant differences were only detected in the high-dose XTSJ group at 48 h (78.57% ± 6.94%) and 72 h (72.12% ± 7.68%) when compared with the other CD44- groups (P < 0.05). Notably, these differences were highly consistent with the Notch-1, Hes1, VEGF and Ki-67 expression in these cells. Similarly, in vivo, XTSJ decoction inhibited tumor growth in a dose-dependent manner. A significant difference was observed in the medium- (1.76 ± 0.15) and high-dose XTSJ (1.33 ± 0.081) groups compared with the GCSCs control group (2.72 ± 0.25) and the low-dose XTSJ group (2.51 ± 0.25) (P < 0.05). We also detected a remarkable decrease of MVD in the medium- (7.10 ± 0.60) and high-dose XTSJ (5.99 ± 0.47) groups compared with the GCSC control group (8.15 ± 0.42) and the low-dose XTSJ group (8.14 ± 0.46) (P < 0.05). Additionally, CD44 expression was decreased in these groups [medium- (4.43 ± 0.45) and high-dose XTSJ groups (3.56 ± 0.31) vs the GCSC control (5.96 ± 0.46) and low dose XTSJ groups (5.91 ± 0.38)] (P < 0.05). The significant differences in Notch-1, Hes1, VEGF and Ki-67 expression highly mirrored the results of XTSJ decoction in inhibiting tumor growth, MVD and CD44 expression. CONCLUSION: Notch-1 may play an important role in regulating the proliferation of GCSCs; XTSJ decoction could attenuate tumor angiogenesis, at least partially, by inhibiting Notch-1.

To explore the syndrome differentiation in traditional Chinese medicine (TCM) and gene protein expression in gastric carcinoma.Preoperative data of gastric cancer cases were collected from the General Surgery Department and classified according to the criteria for syndrome differentiation in TCM. E-cadherin (E-cad) and ICAM-1 gene protein expressions were detected in postoperative specimens from these cases by the immunohistochemical EnVision two-step method.The E-cad positive expression rate was 90% in 100 cases of gastric carcinoma. The difference in E-cad expression was significant between the different syndrome differentiation types in TCM (P0.01). Further group-group comparison showed that there was a significant difference in E-cad expression between the stagnation of phlegm-damp type and the deficiency in both qi and blood and the deficiency-cold of stomach and spleen types, where E-cad expression was high. There was no significant difference between the internal obstruction of stagnant toxin type and the in-coordination between liver and stomach type, where E-cad expression was relatively low. The ICAM-1 positive expression rate was 58%, and there was no statistically significant difference between the two groups (c2 = 8.999, P0.05).E-cad expression is relatively low in the internal obstruction of stagnant toxin type and the in-coordination between liver and stomach type, where tumor development and metastasis may be associated with low E-cad expression, or with low homogeneous adhesiveness between tumor cells.

AIM: To analyze the characteristics of gastric cancer based on the syndromic classifications, and to provide the basis for standardizing the syndromic classifications of gastric cancer in terms of Traditional Chinese Medicine (TCM). METHODS: The cases (n = 767) of gastric cancer were collected from several hospitals. The symptoms and clinical signs on TCM (118 in total) were obtained by questionnaire, and their rates in different syndromic classifications were analyzed. RESULTS: Two hundred and fifty-two cases (32.86%) belonged to the type of deficiency-cold of the spleen and stomach, and 233(30.38%) belonged to the discordance of liver-stomach. The numbers of cases, which belonged to the classification of the stasis and endogenous toxics, the deficiency of both Qi and blood, the stagnation of phlegm-damp, Yin-insufficiency due to stomach-heat, were 90(11.73%), 74(9.65%), 65(8.47%) and 55(7.17%), respectively. Only 12 out of 118 symptoms and physical signs had no significant difference among the 6 gastric cancer classifications on TCM. The other 106 symptoms and physical signs were markedly different among the 6 syndromic classifications (all P