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10 results on '"DE SIMONE, NICOLA ALESSANDRO"'

1. Monofunctionalized Fluorinated Bambusurils and Their Conjugates for Anion Transport and Extraction

Author

De Simone, Nicola Alessandro, Chvojka, Matúš, Lapešová, Jana, Martínez-Crespo, Luis, Slávik, Petr, Sokolov, Jan, Butler, Stephen J., Valkenier, Hennie, and Šindelář, Vladimír

Subjects
Anions, Chlorides, Crown Ethers, Organic Chemistry, Lipid Bilayers
Abstract

Bambusurils are macrocyclic molecules that are known for their high binding affinity and selectivity toward anions. Here, we present the preparation of two bambusurils bearing fluorinated substituents and one carboxylic function. These monofunctionalized bambusurils were conjugated with crown ether and cholesterol units. The resulting conjugates were successfully tested in liquid-liquid extraction of inorganic salts and chloride/bicarbonate transport across lipid bilayers.

Published
2022

2. Monofunctionalized fluorinated bambus[6]urils

Author

1st International Supramolecular Chemistry Summer School (29.5.-2.6.2022: Santa Margherita di Pula, Italy), Chvojka, Matúš, De Simone, Nicola Alessandro, Lapešová, Jana, Martinez Crespo, Luis, Valkenier, Hennie, Šindelář, Vladimír, 1st International Supramolecular Chemistry Summer School (29.5.-2.6.2022: Santa Margherita di Pula, Italy), Chvojka, Matúš, De Simone, Nicola Alessandro, Lapešová, Jana, Martinez Crespo, Luis, Valkenier, Hennie, and Šindelář, Vladimír

Abstract

info:eu-repo/semantics/nonPublished

Published
2022

3. Monofunctionalized fluorinated bambus[6]urils

Author

Journée Scientifique SRC 2022 The many facets of mechanochemistry (18.10.2022: Liège), Chvojka, Matúš, De Simone, Nicola Alessandro, Lapešová, Jana, Martinez Crespo, Luis, Valkenier, Hennie, Šindelář, Vladimír, Journée Scientifique SRC 2022 The many facets of mechanochemistry (18.10.2022: Liège), Chvojka, Matúš, De Simone, Nicola Alessandro, Lapešová, Jana, Martinez Crespo, Luis, Valkenier, Hennie, and Šindelář, Vladimír

Abstract

info:eu-repo/semantics/nonPublished

Published
2022

4. Monofunctionalized fluorinated bambus[6]urils

Author

17th Belgian Organic Synthesis Symposium (3.-8.7.2022: Namur), Chvojka, Matúš, De Simone, Nicola Alessandro, Lapešová, Jana, Martinez Crespo, Luis, Valkenier, Hennie, Šindelář, Vladimír, 17th Belgian Organic Synthesis Symposium (3.-8.7.2022: Namur), Chvojka, Matúš, De Simone, Nicola Alessandro, Lapešová, Jana, Martinez Crespo, Luis, Valkenier, Hennie, and Šindelář, Vladimír

Abstract

info:eu-repo/semantics/nonPublished

Published
2022

5. Cover profile: Transmembrane Transport of Bicarbonate Unravelled

Author

Martinez Crespo, Luis, Hewitt, Sarah H., De Simone, Nicola Alessandro, Šindelář, Vladimír, Davis, Anthony P., Butler, Stephen, and Valkenier, Hennie

Subjects
Chimie organique, Physico-chimie générale, Chimie des colloïdes, Chimie, Chimie des surfaces et des interfaces
Abstract

info:eu-repo/semantics/published

Published
2021

6. Transmembrane Bicarbonate Transport Unraveled

Author

SupraMat (11-12 February 2021: online), Martinez Crespo, Luis, Hewitt, Sarah H., De Simone, Nicola Alessandro, Šindelář, Vladimír, Davis, Anthony P., Butler, Stephen, Valkenier, Hennie, SupraMat (11-12 February 2021: online), Martinez Crespo, Luis, Hewitt, Sarah H., De Simone, Nicola Alessandro, Šindelář, Vladimír, Davis, Anthony P., Butler, Stephen, and Valkenier, Hennie

Abstract

info:eu-repo/semantics/published

Published
2021

7. Transmembrane Transport of Bicarbonate Unravelled

Author

Martinez Crespo, Luis, Hewitt, Sarah H., De Simone, Nicola Alessandro, Šindelář, Vladimír, Davis, Anthony P., Butler, Stephen, Valkenier, Hennie, Martinez Crespo, Luis, Hewitt, Sarah H., De Simone, Nicola Alessandro, Šindelář, Vladimír, Davis, Anthony P., Butler, Stephen, and Valkenier, Hennie

Abstract

Anion receptors can be used to transport ions across lipid bilayers, which has potential for therapeutic applications. Synthetic bicarbonate transporters are of particular interest, as defects in transmembrane transport of bicarbonate are associated with various diseases. However, no convenient method exists to directly observe bicarbonate transport and study the mechanisms involved. Here, an assay is presented that allows the kinetics of bicarbonate transport into liposomes to be monitored directly and with great sensitivity. The assay utilises an encapsulated europium(III) complex, which exhibits a large increase in emission intensity upon binding bicarbonate. Mechanisms involving CO2 diffusion and the dissipation of a pH gradient are shown to be able to lead to an increase in bicarbonate concentration within liposomes, without transport of the anion occurring at all. By distinguishing these alternative mechanisms from actual bicarbonate transport, this assay will inform the future development of bicarbonate transporters., SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2021

8. Direct Monitoring of Bicarbonate Transport by Emission Spectroscopy

Author

Martinez Crespo, Luis, Hewitt, Sarah H., De Simone, Nicola Alessandro, Šindelář, Vladimír, Davis, Anthony P., Butler, Stephen, Valkenier, Hennie, Martinez Crespo, Luis, Hewitt, Sarah H., De Simone, Nicola Alessandro, Šindelář, Vladimír, Davis, Anthony P., Butler, Stephen, and Valkenier, Hennie

Abstract

info:eu-repo/semantics/published

Published
2020

9. Direct monitoring of bicarbonate transport

Author

ISMSC (25 August 2020: Twitter), Martinez Crespo, Luis, Hewitt, Sarah H., De Simone, Nicola Alessandro, Šindelář, Vladimír, Davis, Anthony P., Butler, Stephen, Valkenier, Hennie, ISMSC (25 August 2020: Twitter), Martinez Crespo, Luis, Hewitt, Sarah H., De Simone, Nicola Alessandro, Šindelář, Vladimír, Davis, Anthony P., Butler, Stephen, and Valkenier, Hennie

Abstract

https://twitter.com/lmartinezcrespo/status/1298028733471821826https://twitter.com/ChemicalScience/status/1300770160400388099, info:eu-repo/semantics/published

Published
2020

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