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1. Optimal strategies for the decumulation of retirement savings under differing appetites for liquidity and investment risks

Author

Avanzi, B, De Felice, L, Avanzi, B, and De Felice, L

Abstract

A retiree’s appetite for risk is a common input into the lifetime utility models that are traditionally used to find optimal strategies for the decumulation of retirement savings. In this work, we consider a retiree with potentially differing appetites for the key financial risks of decumulation: liquidity risk and investment risk. We set out to determine whether these differing risk appetites have a significant impact on the retiree’s optimal choice of decumulation strategy. To do so, we design and implement a framework which selects the optimal decumulation strategy from a general set of admissible strategies in line with a retiree’s goals, and under differing appetites for the key risks of decumulation. Overall, we find significant evidence to suggest that a retiree’s differing appetites for different decumulation risks will impact their optimal choice of strategy at retirement. Through an illustrative example calibrated to the Australian context, we find results which are consistent with actual behaviours in this jurisdiction (in particular, a shallow market for annuities), which lends support to our framework and may provide some new insight into the so-called annuity puzzle.

Published
2024

6. Living Planet Report 2018: Aiming Higher

Author

Barrett, M., Belward, A., Bladen, S, Breeze, T., Burgess, N., Butchart, S., Clewclow, H., Cornell, S., Cottam, A., Croft, S., de Carlo, G., de Felice, L., de Palma, A., Deinet, S., Downie, R., Drijver, C., Fischler, B., Freeman, R., Gaffney, O., Galli, A, Gamblin, P., Garratt, M., Gorelick, N., Green, J., Grooten, M., Hanscom, L., Hill, S., Hilton-Taylor, C., Jones, A., Juniper, T., Khan, H., Kroodsma, D., Leclere, D., Llewellyn, G., Mace, G., McRae, L., Mo, K., Opperman, J., Orgiazzi, A., Orr, S., Pacheco, P., Palomares, D., Pauly, D., Pekel, J.-F., Pendleton, L., Purvis, A., Radcliffe, N., Roxburgh, T., Scholes, B, Senapathi, D., Tanzer, D., Thieme, M., Tickner, D., Tittonell, P., Trathan, P., Visconti, P., Wackernagel, M., West, C., Zwaal, N., Barrett, M., Belward, A., Bladen, S, Breeze, T., Burgess, N., Butchart, S., Clewclow, H., Cornell, S., Cottam, A., Croft, S., de Carlo, G., de Felice, L., de Palma, A., Deinet, S., Downie, R., Drijver, C., Fischler, B., Freeman, R., Gaffney, O., Galli, A, Gamblin, P., Garratt, M., Gorelick, N., Green, J., Grooten, M., Hanscom, L., Hill, S., Hilton-Taylor, C., Jones, A., Juniper, T., Khan, H., Kroodsma, D., Leclere, D., Llewellyn, G., Mace, G., McRae, L., Mo, K., Opperman, J., Orgiazzi, A., Orr, S., Pacheco, P., Palomares, D., Pauly, D., Pekel, J.-F., Pendleton, L., Purvis, A., Radcliffe, N., Roxburgh, T., Scholes, B, Senapathi, D., Tanzer, D., Thieme, M., Tickner, D., Tittonell, P., Trathan, P., Visconti, P., Wackernagel, M., West, C., and Zwaal, N.

Published
2018

7. Impact of nucleic acid testing for hepatitis B virus, hepatitis C virus, and human immunodeficiency virus on the safety of blood supply in Italy: a 6-year survey

Author

Claudio, Velati, Luisa, Romano, Laura, Fomiatti, Lorella, Baruffi, Alessandro Remo Zanetti, Research Group: Sciariada, Simti L., Lobbiani, L., Prati, D., Marconi, M., Ravagnani, E., Rossi, E., Rossini, S., Bellavita, P., Moroni, G. A., Bodini, U., Pagliaro, P., Azzario, F., Rossi, D., Sciorelli, G., Salvaneschi, L., Cambie, G., Marini, M., Pizzoccolo, G., Gazzola, G. B., Peres, E., Mariottini, C., Graziani, G., Baicchi, U., Palla, P., Vacri, L., Strada, P., Miceli, M., Iudicone, P., Girelli, Gabriella, Ursitti, A., De Silvestro, G., Gentile, R., Di Paola, P., Manca, M., Martinelli, L., Bonomo, P., Calabrese, S., Pistolese, G., Aprili, G., Bressan, F., Ripamonti, M., Catalano, A., Gallerano, P., Giacalone, I., Fiorilla, A., Giannotti, G., Cantella, R., Di Persia, M. G., Esposito, V., Sardella, C., Di Monte, D., Bajorek, M., Reina, A., Silvani, C. M., Piani, M., Salvoni, G., De Felice, L., Macri, M., De Palma, M., Vecchi, C., Belloni, M., Bettini, C., Ghiazza, P., De Santis, D., Di Mauro, L., Antoncecchi, S., Rinaldi, C., Allegreita, G., Siracusano, L., Adami, R., Lanteri, M., Mazzei, C., Tagariello, G., Gajo, G. B., Berti, P., Giordano, C., Palazzesi, G., Del Gusto, B., Pavone, A., Vacchini, M., Tomasini, A., Vaselli, G., Fiorin, F., Bresolin, G., Bertola, F., Testa, D., Semino, G., Tomasini, I., Zucchelli, P., Chicchi, R., Peano, G., Franchi, D., Sabelli, M., Miloro, G., Di Gregorio, P., Reimondo, P., Cimino, G., Tripodi, G., Borzini, P., Tarditi, M., Cocchi, T., Pata, V., Santarelli, R., Geremicca, W., Minerva, A., Maccarione, F. P., Solanda, F., Rivasi, P., Carubia, F., Prinoth, O., Ostuni, A., Bossio, M., Maggiotto, A., Valentino, F., Puzzonia, P., and Source Musto, C.

Subjects
Adult, Male, Hepatitis B virus, Genotype, Hepacivirus, Hepatitis C virus, Immunology, Blood Donors, HIV Infections, medicine.disease_cause, Virus, Flaviviridae, Orthohepadnavirus, Risk Factors, Seroepidemiologic Studies, medicine, Humans, Mass Screening, Immunology and Allergy, Aged, biology, business.industry, HIV, virus diseases, Hematology, Middle Aged, Hepatitis B, biology.organism_classification, medicine.disease, Hepatitis C, Virology, digestive system diseases, Italy, Hepadnaviridae, Virus Diseases, Health Care Surveys, Blood Banks, Female, Morbidity, Safety, business, Risk Reduction Behavior
Abstract

BACKGROUND: Nucleic acid testing (NAT) for hepatitis C virus (HCV) and human immunodeficiency virus (HIV) has been implemented in several European countries and in the United States, while hepatitis B virus (HBV) NAT is still being questioned by opinions both in favor and against such an option, depending on the HBV endemicity, health care resources, and expected benefits. STUDY DESIGN AND METHODS: This survey was aimed to assess the NAT impact in improving the safety of blood supply in Italy, 6 years after implementation. The study involved 93 Italian transfusion centers and was carried out in 2001 through 2006. A total of 10,776,288 units were tested for the presence of HCV RNA, 7,932,430 for HIV RNA, and 3,405,497 for HBV DNA, respectively. RESULTS: Twenty-seven donations or 2.5 per million tested were HCV RNA–positive/anti-HCV–negative; 14 or 1.8 per million units tested were HIV RNA–positive/anti-HIV–negative; and 197 or 57.8 per million donations tested were HBV DNA–positive/hepatitis B surface antigen–negative. Of the latter, 8 (2.3/106) were collected from donors in the window phase of infection and 189 (55.5/106) from donors with occult HBV. Sixty-eight percent of the latter donors had hepatitis B surface antibody, 74.5 percent of whom with concentrations considered protective (≥10 mIU/mL). CONCLUSION: NAT implementation has improved blood safety by reducing the risk of entering 2.5 HCV and 1.8 HIV infectious units per million donations into the blood supply. The yield of NAT in detecting infectious blood before transfusion was higher for HBV than for HCV or HIV. However, the benefit of HBV NAT in terms of avoided HBV-related morbidity and mortality in blood recipients needs to be further evaluated.

Published
2008

30. Quantitatively different red cell/nucleated cell chimerism in patients with long-term, persistent hematopoietic mixed chimerism after bone marrow transplantation for thalassemia major or sickle cell disease

Author

Andreani, M., primary, Testi, M., additional, Gaziev, J., additional, Condello, R., additional, Bontadini, A., additional, Tazzari, P. L., additional, Ricci, F., additional, De Felice, L., additional, Agostini, F., additional, Fraboni, D., additional, Ferrari, G., additional, Battarra, M., additional, Troiano, M., additional, Sodani, P., additional, and Lucarelli, G., additional

Published
2010
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35. Unrelated cord blood transplant in children with high-risk acute lymphoblastic leukemia: a long-term follow-up

Author

Iori, A. P., primary, Arcese, W., additional, Milano, F., additional, Calabrese, E., additional, Torelli, G. F., additional, Barberi, W., additional, Mascolo, M. G., additional, De Felice, L., additional, Screnci, M., additional, Lucarelli, B., additional, Malandruccolo, L., additional, Perrone, M. P., additional, Salvatori, S., additional, Laurenti, L., additional, Iannella, E., additional, Ricci, R., additional, Moleti, M. L., additional, and Foa, R., additional

Published
2007
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40. Association of Intermediate Osteopetrosis with Poikiloderma

Author

Migliaccio, S., primary, Luciani, M., additional, Taranta, A., additional, De Rossi, G., additional, Minisola, S., additional, El Hachem, M., additional, Bosman, C., additional, De Felice, L., additional, Boldrini, R., additional, Corsi, A., additional, Bianco, P., additional, and Teti, A., additional

Published
1999
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44. Potassium and sodium ion current noise in the membrane of the squid giant axon.

Author

Conti, F, De Felice, L J, and Wanke, E

Abstract

1. The spectral density of current noise power from 20 mm segments of giant axons of the squid Loligo vulgaris has been measured under space‐clamp and voltage‐clamp conditions. From 4 to 1000 Hz the measured noise is larger by several orders of magnitude than the theoretical thermal noise. The amplifier's noise, which may yield appreciable contributions above 200 Hz, could be evaluated and subtracted from the total noise using direct measurements of the membrane impedance...

Published
1975
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46. In vitro effects of human recombinant alpha-2b interferon on Ph1+ chronic myelogenous leukemia cells maintained in long term marrow cultures: a functional and morphological analysis

Author

Sandrelli A, De Fabritiis P, Arturo Cafolla, Nanni M, Simone F, De Felice L, Gd, Di Nucci, and Mandelli F

Subjects
Cytogenetics, Histocytochemistry, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Stem Cells, Interferon Type I, Neoplastic Stem Cells, Tumor Cells, Cultured, Humans, Interferon-alpha, Bone Marrow Cells, Interferon alpha-2, Cells, Cultured, Recombinant Proteins
Abstract

In this study in vitro results obtained with hu rec IFN-alpha 2b on Ph1+ stem cells from patients with chronic myelogenous leukemia in chronic phase (CML in CP) will be discussed: cells were incubated with different IFN concentrations (100, 1000, 10000 IU/ml) for different times (24, 96 hrs, 8, 15, days) and maintained in long term marrow cultures (LTMC); CFU-GM assay, cytochemistry and cytogenetic analyses were performed weekly. A high sensitivity of CML cells to the in vitro treatment with IFN was observed. Cell count in LTMC showed a progressive reduction inversely proportional to time of incubation and concentration of IFN; a marked decrease in colony growth was observed at the end of incubations and during the course of LTMC. Low concentrations of IFN permitted a morphological maturation and the expression of alkaline phosphatase. Cytogenetic analyses showed a marked reduction of mytoses in cultures treated with high concentrations of IFN as result of a combined cytostatic and cytolitic effect; the persistance of 100% Ph1+ cells in LTMC and in CFU-GM colonies might be related, as opposed to in vivo results, to different IFN exposure conditions or might be influenced by other factors.

Published
1989

49. Early-onset monocyte-B-natural killer-dendritic cells’ deficiency successfully treated with hematopoietic stem cell transaplantation

Author

Samantha Scaramuzza, Maria Chiriaco, Luigi Racioppi, Maria Luisa Romiti, Giuseppe Palumbo, Paolo Palma, Susanna Livadiotti, Maurizio Caniglia, Rita Maria Pinto, Silvia Di Cesare, Caterina Cancrini, Rita De Vito, Lidia De Felice, Gigliola Di Matteo, Alessia Scarselli, Paolo Rossi, Alessandro Aiuti, Alain Fischer, Cancrini, C., Scarselli, A., Scaramuzza, S., Chiriaco, M., Di Cesare, S., Di Matteo, G., Romiti, M. L., Palma, P., De Felice, L., Palumbo, G., Pinto, R. M., De Vito, R., Racioppi, Luigi, Livadiotti, S., Fischer, A., Rossi, P., Caniglia, M., Aiuti, A., Cancrini, C, Scarselli, A, Scaramuzza, S, Chiriaco, M, Di Cesare, S, Di Matteo, G, Romiti, Ml, Palma, P, De Felice, L, Palumbo, G, Pinto, Rm, De Vito, R, Racioppi, L, Livadiotti, S, Fischer, A, Rossi, P, Caniglia, M, and Aiuti, Alessandro

Subjects
Settore MED/38 - Pediatria Generale e Specialistica, business.industry, medicine.medical_treatment, Monocyte, Immunology, LINEAGE, Hematopoietic stem cell transplantation, Immunologic Deficiency Syndromes, medicine.anatomical_structure, medicine, Immunology and Allergy, business, Early onset
Published
2011

50. Quantitatively different red cell/nucleated cell chimerism in patients with long-term, persistent hematopoietic mixed chimerism after bone marrow transplantation for thalassemia major or sickle cell disease

Author

Daniela Fraboni, Andrea Bontadini, Marco Andreani, Pier Luigi Tazzari, F Agostini, Manuela Testi, Francesca Ricci, Lidia De Felice, Pietro Sodani, R. Condello, Guido Lucarelli, Maria Troiano, Mariarosa Battarra, Giuliana Ferrari, Javid Gaziev, Andreani, M, Testi, M, Gaziev, J, Condello, R, Bontadini, A, Tazzari, Pl, Ricci, F, DE FELICE, L, Agostini, F, Fraboni, D, Ferrari, Giuliana, Battarra, M, Troiano, M, Sodani, P, and Lucarelli, G.

Subjects
Adult, Male, Erythrocytes, Adolescent, medicine.medical_treatment, Hematopoietic stem cell transplantation, Anemia, Sickle Cell, Chimerism, Blood cell, Young Adult, Nucleated cell, medicine, Humans, Child, Editorial and Perspectives, Bone Marrow Transplantation, Cell Nucleus, business.industry, Graft Survival, beta-Thalassemia, Hematology, Tissue Donors, Transplantation, Hemoglobinopathies, Red blood cell, Haematopoiesis, medicine.anatomical_structure, Child, Preschool, Immunology, Original Article, Female, Bone marrow, Stem cell, business
Abstract

Background. Persistent mixed chimerism represents a state wherein recipient and donor cells stably co-exist after haematopoietic stem cell transplantation. However, since in mostly of the studies reported in literature the engraftment state was observed in the nucleated cells, in this paper we determined the donor origin in the mature erythrocytes of patients with persistent mixed chimerism after transplantation for haemoglobinopathies. Results were compared with the engraftment state observed in singularly picked-up burst-forming unit-erythroid colonies and in the nucleated cells collected from the peripheral blood and from the marrow. Design and Methods. The donor origin of the erythrocytes was determined analyzing differences on the surface antigens of the erythrocytes suspension after incubation with anti-ABO and/or anti-C, -c, -D, -E and -e monoclonal antibodies by a flow cytometer. Short tandem repeats analysis was used to determine the donor origin of nucleated cells and burst-forming unit-erythroid colonies singularly picked up after 14 days incubation. Results. A proportion of donor-derived nucleated cells of 71%, 46%, 15% and 25% was observed at day 1364, 1385, 1314 and 932 respectively, in four transplanted patients affected by haemoglobinopathies. Similar results were also obtained in the erythroid precursors, analyzing the donor/recipient origin of the burst-forming unit-erythroid colonies, while on the contrary, at the same days of observation, a proportion of 100%, 100%, 73% and 90% donor-derived erythrocytes was observed in the four patients with persistent mixed chimerism. Conclusions. Our results showed that mostly of the erythrocytes present in four long-term transplanted patients affected by haemoglobinopathies and characterized by the presence of few donor engrafted nucleated cells were of donor origin. The indication that small proportions of donor engrafted cells might be sufficient to clinical control the disease in patients affected by haemoglobinopathies is relevant, although the biological mechanisms underlying these observations need to be further investigated.

Published
2010

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