32 results on '"DE ALOYSIO, D"'
Search Results
2. Embryonic Production of Nitric Oxide and Its Role in Implantation: A Pilot Study
- Author
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Battaglia, C., Ciotti, P., Notarangelo, L., Fratto, R., Facchinetti, F., and de Aloysio, D.
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- 2003
- Full Text
- View/download PDF
3. Three-dimensional power Doppler imaging of uterine artery pseudoaneurysm treated unsuccessfully with selective embolization
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Alboni, C., Rosati, F., Sansavini, S., Bartalena, T., Mancini, F., De Iaco, P., de Aloysio, D., and Orsini, L. F.
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- 2009
- Full Text
- View/download PDF
4. Cervical length and risk of antepartum bleeding in women with complete placenta previa
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GHI, T., CONTRO, E., MARTINA, T., PIVA, M., MORANDI, R., ORSINI, L. F., MERIGGIOLA, M. C., PILU, G., MORSELLI-LABATE, A. M., DE ALOYSIO, D., RIZZO, N., and PELUSI, G.
- Published
- 2009
5. Plasma catecholamines in pre- and in postmenopausal women with mild to moderate essential hypertension
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Villecco, AS, de Aloysio, D, Radi, D, Sprovieri, G, Bargossi, AM, Grossi, G, Gueli, C, Salgarello, M, and Cavrini, G
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- 1997
- Full Text
- View/download PDF
6. Clinical trial: modulation of human placental multidrug resistance proteins in cholestasis of pregnancy by ursodeoxycholic acid
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AZZAROLI, F., MENNONE, A., FELETTI, V., SIMONI, P., BAGLIVO, E., MONTAGNANI, M., RIZZO, N., PELUSI, G., DE ALOYSIO, D., LODATO, F., FESTI, D., COLECCHIA, A., RODA, E., BOYER, J. L., and MAZZELLA, G.
- Published
- 2007
7. Female precocious puberty, obesity and polycystic-like ovaries
- Author
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BATTAGLIA, C., DE IACO, P., IUGHETTI, L., MANCINI, F., PERSICO, N., GENAZZANI, A. D., VOLPE, A., and DE ALOYSIO, D.
- Published
- 2005
8. Transdermal HRT and Doppler findings in normotensive and hypertensive postmenopausal patients
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PERSICO, N., MANCINI, F., ARTINI, P. G., DE IACO, P., VOLPE, A., DE ALOYSIO, D., and BATTAGLIA, C.
- Published
- 2005
9. Effects of an oral contraceptive combination containing 0.150 mg desogestrel plus 0.020 mg ethinyl estradiol on healthy premenopausal women
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de Aloysio, D., Mauloni, M., Roncuzzi, A., Altieri, P., Bottiglioni, F., Trossarelli, G. F., Fanizza, G., and Covelli, A.
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- 1993
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10. Pelvic ultrasound and color Doppler findings in different isosexual precocities
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BATTAGLIA, C., MANCINI, F., REGNANI, G., PERSICO, N., IUGHETTI, L., and DE ALOYSIO, D.
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- 2003
- Full Text
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11. Osteoporosi: stile di vita e farmaci
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Bacchi Modena, A, Bagni, B, De Aloysio, D, Giulini, N, Pansini, Fs, Volpe, Annibale, Aldrigo, A, Arangino, S, Bergamini, C, Fontanesi, V, Gabbi, D, Generali, Matteo, Malmusi, S, Vultaggio, E, and Cagnacci, Angelo
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osteoporosi - Published
- 2008
12. The foetal-maternal circulation of bile acids and bilirubin: effects of cholestasis and UDCA administration
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Azzaroli, F., Baglivo, E., Montagnani, M., Feletti, V., Simoni, P., Locatelli, M., DE ALOYSIO, D., Pelusi, G., Lodato, F., Festi, D., Colecchia, A., Roda, A., Roda, E., G. MAZZELLA., E. Baglivo, F. Azzaroli, M. Montagnani, V. Feletti, P. Simoni, M. Locatelli, D. De Aloysio, G. Pelusi, F. Lodato, D. Festi, A. Colecchia, A. Roda, E. Roda, G. Mazzella, and G. Mazzella.
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PREGNANCY ,BILIRUBIN ,CHOLESTASIS ,BILE ACIDA ,BILE ACIDS ,UDCA - Published
- 2006
13. Transdermal HRT and Doppler findings in normotensive and hypertensive postmenopausal patients
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Persico, N, Mancini, F, Artini, Pg, De Iaco, P, Volpe, Annibale, De Aloysio, D, Battaglia, C., N. Persico, F.Mancini, P.G. Artini, P. Deiaco, A.Volpe, D.de Aloysio, and C.Battaglia
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hypertension ,HRT ,Urinary Bladder ,Medroxyprogesterone Acetate ,Administration, Cutaneous ,Ophthalmic Artery ,Humans ,Doppler ,plasma viscosity ,thromboxane ,ultrasound ,Analysis of Variance ,Estradiol ,Estrogen Replacement Therapy ,Uterus ,Ultrasonography, Doppler ,Arteries ,Middle Aged ,Blood Viscosity ,Postmenopause ,Thromboxane B2 ,Regional Blood Flow ,Case-Control Studies ,Hypertension ,Linear Models ,Female ,Vascular Resistance ,Carotid Artery, Internal - Abstract
To evaluate the effects of transdermal hormone replacement therapy (HRT) on plasma viscosity, serum levels of thromboxane B2 (TXB2) and vascular impedance in the uterine, bladder wall, internal carotid and ophthalmic arteries in normotensive and hypertensive postmenopausal patients.Thirty postmenopausal patients underwent continuous estradiol transdermal supplementation at a dose of 50 microg/day and 12-day courses of medroxyprogesterone acetate 10 mg/day every 2 months. The women were divided into two groups according to their blood pressure: normotensive women (Group 1, n=14) and hypertensive subjects (Group 2, n=16). Before starting HRT and after 6 months of therapy, the patients underwent: transvaginal ultrasonographic examination of the pelvic organs; Doppler examination of the blood flow velocities in the uterine, bladder wall, internal carotid and ophthalmic arteries; and analysis of plasma viscosity and plasma TXB2.After 6 months of HRT plasma viscosity had decreased in both groups (mean reduction in Group 1, (14+/-1)%, P=0.005; mean reduction in Group 2, (10+/-1)%, P=0.005) as had the TXB2 levels (mean reduction in Group 1, (93+/-2)%, P0.001; mean reduction in Group 2, (92+/-3)%, P0.001). The mean percentage reduction in plasma viscosity was smaller in hypertensive women than in normotensive women (P0.05). There was also a significant reduction in vascular impedance in the uterine artery (mean reduction in Group 1, (16+/-1)%, P=0.005; mean reduction in Group 2, (19+/-1)%, P=0.005), the bladder wall arteries (mean reduction in Group 1, (23+/-2)%, P=0.005; mean reduction in Group 2, (18+/-1)%, P=0.005), the internal carotid artery (mean reduction in Group 1, (25+/-1)%, P=0.005; mean reduction in Group 2, (26+/-1)%, P=0.005) and the ophthalmic artery (mean reduction in Group 1, (24+/-2)%, P=0.005; mean reduction in Group 2, (16+/-1)%, P=0.005). The percentage reduction in vascular impedance did not differ significantly between the two groups.Our results show that transdermal HRT is effective in reducing plasma viscosity, TXB2 levels and vascular impedance in the peripheral and central vessels both in normotensive and hypertensive postmenopausal patients.
- Published
- 2005
14. Stagionalità e menopausa
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Cagnacci, Angelo, Generali, Matteo, Pansini, Fs, Bacchi Modena, A, Giulini, N, Mollica, G, De Aloysio, D, Vadora, E, and Volpe, Annibale
- Published
- 2005
15. Tibolone, oral or transdermal hormone replacement and colour Doppler analysis: a prospective, randomised pilot study
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Battaglia, C, Mancini, F, Persico, N, Penacchioni, P, Regnani, G, Volpe, Annibale, and de Aloysio, D.
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Medroxyprogesterone ,Time Factors ,Hormone Replacement Therapy ,Norpregnenes ,Uterus ,Administration, Oral ,Thromboxanes ,Androgen Antagonists ,Estrogens ,Pilot Projects ,Middle Aged ,Administration, Cutaneous ,Postmenopause ,Ophthalmic Artery ,Doppler ,HRT ,menopause ,ultrasonography ,tibolone ,Humans ,Female ,Prospective Studies ,Ultrasonography, Doppler, Color ,Blood Flow Velocity ,Carotid Artery, Internal - Abstract
To compare the plasma thromboxane, the plasma viscosity and the Doppler flow modifications induced by tibolone and by oral or transdermal continuous combined hormone replacement therapy.Forty-two post-menopausal patients underwent either on: oral daily treatment with tibolone (2.5 mg) (Group I; n= 14); or continuous oral administration of 0.625 mg conjugated equine estrogens + medroxyprogesterone 5 mg per day (Group II; n = 14 ); or continuous estradiol transdermal supplementation, at a dose of 50 microg per day, + medroxyprogesterone 5 mg per day (Group III; n = 14 ). The duration of the study was 6 months and the patients were submitted to transvaginal ultrasonographic evaluation of pelvic organs; Doppler analysis of the uterine, internal carotid and ophthalmic arteries; thromboxane and plasma viscosity assays in basal condition, and at 1, 3 and 6 months from the beginning of the study.Although the endometrial thickness increased significantly, there were no cases in which it exceeded the normal range (or = 5 mm). In all the three groups, the pulsatility index of the uterine, internal carotid and ophthalmic arteries significantly decreased during the therapy showing a reduced impedance since the first month of treatment. Similar variations were observed for the peak systolic blood flow velocity of the internal carotid and ophthalmic arteries. Hormone replacement therapy and tibolone induced a deep, significant and rapid decrease in plasma thromboxane and plasma viscosity levels.Hormone replacement therapy and tibolone seem to have beneficial effects on vascular and hemorrheological parameters.
- Published
- 2003
16. Phalangeal osteosonogrammetry study: age-related changes, diagnostic sensitivity, and discrimination power. The Phalangeal Osteosonogrammetry Study Group
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Wüster, C, Albanese, C, DE ALOYSIO, D, Duboeuf, F, Gambacciani, M, Gonnelli, Stefano, Glüer, Cc, Hans, D, Joly, J, Reginster, Jy, DE TERLIZZI, F, and Cadossi, R.
- Subjects
Signal processing ,Adult ,Aged, 80 and over ,Male ,Aging ,Bone ,Osteoporosis ,Phalanges ,Ultrasound ,Discriminant Analysis ,Sensitivity and Specificity ,Bone and Bones ,Fractures, Bone ,Humans ,Female ,Child ,Aged ,Densitometry ,Ultrasonography - Abstract
Phalangeal osteosonogrammetry was introduced as a method for bone tissue investigation in 1992. It is based on the measure of the velocity of ultrasound (amplitude-dependent speed of sound [AD-SoS]) and on the interpretation of the characteristics of the ultrasound signal. In this study we have collected a database of 10,115 subjects to evaluate the performance of AD-SoS and to develop a parameter that is able to quantify the signal characteristics: ultrasound bone profile index (UBPI). The database only includes females of which 4.5% had documented vertebral osteoporotic fractures, 16% lumbar spine dual X-ray absorptiometry (DXA), and 6% hip DXA. The analysis of the ultrasound signal has shown that with aging the UBPI, first wave amplitude (FWA), and signal dynamics (SDy) follow a trend that is different from the one observed for AD-SoS; that is, there is no increase during childhood. In the whole population, the risk of fracture per SD decrease for AD-SOS was odds ratio (OR) 1.71 (CI, 1.58-1.84). The AD-SoS in fractured subjects was significantly lower than in a group of age-matched nonfractured subjects (p0.0001). In a small cohort of hip-fractured patients UBPI proved to be lower than in a control age-matched group (p0.0001). When the World Health Organization (WHO) working group criteria were applied to this population to identify the T score value for osteoporosis, for AD-SoS we found a T score of -3.2 and for UBPI we found a T score of -3.14. Sixty-six percent of vertebral fractures were below the AD-SoS -3.2 T score and 62% were below UBPI -3.14. We observed the highest incidence of fractures (63.6%) among subjects with AD-SoS who had both DXA T score values below the threshold. We conclude from this study that ultrasound investigation at the hand phalanges is a valid methodology for osteoporosis assessment. It has been possible to quantify signal changes by means of UBPI, a parameter that will improve the possibility of investigating bone structure.
- Published
- 2000
17. P41.11: Three-dimensional power Doppler angiography in the diagnosis of pseudoaneurysm of the uterine artery
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Alboni, C., primary, Rosati, F., additional, Sansavini, S., additional, Cappelli, A., additional, Bartalena, T., additional, Zucchini, N., additional, Galaverni, M. C., additional, De Iaco, P., additional, de Aloysio, D., additional, and Orsini, L. F., additional
- Published
- 2007
- Full Text
- View/download PDF
18. P06.13: Transdermal HRT and Doppler findings in normo and hypertensive postmenopausal women
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Persico, N., primary, Mancini, F., additional, Battaglia, C., additional, and de Aloysio, D., additional
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- 2004
- Full Text
- View/download PDF
19. OC088: The heterogenous nature of polycystic ovaries
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Battaglia, C., primary, Mancini, F., additional, Persico, N., additional, and de Aloysio, D., additional
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- 2004
- Full Text
- View/download PDF
20. Validation of italian version of the Women's Health Questionnaire: Assessment of quality of life of women from the general population and those attending menopause centers
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Genazzani, Andrea, Nicolucci, A, Campagnoli, C, Crosignani, P, Nappi, C, Serra, Gb, Bottiglioni, E, Cianci, A, De Aloysio, D, Sarti, Cd, Gambacciani, M, Monteleone, P, Ciaponi, M, Genazzani, Ad, Guaschino, S, Palumbo, G, Petraglia, F, Schonauer, S, Volpe, A, Coronel, Ga, Di Paolantonio, T, Nagni, M, Tempesta, A, Progetto Donna Qualità della Vita Working Group Novo Nordisk Italia, Genazzani, Ar, Nicolucci, A, Campagnoli, C, Crosignani, P, Nappi, Carmine, Serra, Gb, Bottiglioni, E, Cianci, A, De Aloysio, D, Sarti, Cd, Gambacciani, M, Monteleone, P, Ciaponi, M, Genazzani, Ad, Guaschino, S, Palumbo, G, Petraglia, F, Schonauer, S, Volpe, A, Coronel, Ga, Di Paolantonio, T, Nagni, M, and Tempesta, A.
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Gerontology ,Questionnaires ,Psychometrics ,Sexual Behavior ,Population ,MEDLINE ,menopause ,Quality of life ,Memory ,Surveys and Questionnaires ,medicine ,Humans ,education ,Reliability (statistics) ,Aged ,Women's Health Questionnaire ,quality of life ,education.field_of_study ,business.industry ,Discriminant validity ,Obstetrics and Gynecology ,General Medicine ,Middle Aged ,medicine.disease ,Affect, Aged, Female, Humans, Italy, Memory, Menopause, Middle Aged, Psychometrics, Quality of Life, Questionnaires, Sexual Behavior, Sleep, Vasomotor System ,physiology, Women's Health ,Menopause ,Vasomotor System ,Affect ,Italy ,Transgender hormone therapy ,physiology ,Quality of Life ,Women's Health ,Female ,business ,Sleep - Abstract
The Women's Health Questionnaire has been developed and validated in Anglo-Saxon and Swedish populations. The purpose of this study was to evaluate the Italian version of the questionnaire to determine whether cross-cultural differences exist in the perception of quality of life, and to use it to compare the quality of life in women attending menopause centers with that of women in the general population.An Italian version of the Women's Health Questionnaire (WHQ) was produced, using the forward-backward translation method to ensure conceptual equivalence, and approved by the originator. Women were recruited by random selection from the general population and from menopause centers, those taking hormone replacement therapy being ineligible. The questionnaire was completed anonymously at home and mailed to the co-ordinating center. Psychometric evaluation included tests of item convergent and discriminant validity, internal-consistency reliability, test-retest reliability, construct validity and the discriminative properties of the questionnaire.The completeness of the data was good, with missing-value rates consistently low for most items. Item-scale correlations, used to evaluate internal consistency, were also good and the scaling success rate, used to measure item discriminant validity, was high for all scales. Scale scores were reliable for seven out of nine scales and test-retest reliability was excellent. There were few significant differences between the two populations of women in most of the WHQ areas. A comparison of Italian data with published data on English women showed great similarity.The Italian version of the WHO is valid and reproducible. The subjective perception of the menopause and its related problems is similar in geographically and culturally different populations.
21. Interrelationships of interleukin-8 with interleukin-1beta and neutrophils in vaginal fluid of healthy and bacterial vaginosis positive women
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Franco Quadrifoglio, Sabina Cauci, Secondo Guaschino, Davide De Santo, Paola Penacchioni, Domenico De Aloysio, Silvia Driussi, Cauci, S, Guaschino, Secondo, DE ALOYSIO, D, Driussi, S, DE SANTO, D, Penacchioni, P, and Quadrifoglio, F.
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Embryology ,Cellular immunity ,Neutrophils ,Neutrophile ,medicine.medical_treatment ,Physiology ,Biology ,Leukocyte Count ,Vaginal disease ,Reference Values ,Genetics ,medicine ,Humans ,Interleukin 8 ,Molecular Biology ,Interleukin-8 ,Obstetrics and Gynecology ,Interleukin ,Vaginosis, Bacterial ,Cell Biology ,medicine.disease ,Cytokine ,medicine.anatomical_structure ,Reproductive Medicine ,Vagina ,Immunology ,Female ,Bacterial vaginosis ,Interleukin-1 ,Developmental Biology - Abstract
Vaginal innate immunity in response to microbial perturbation is still poorly understood and could be crucial for protection from adverse outcomes. We investigated the relationship between interleukin (IL)-8, IL-1beta and neutrophils in vaginal fluid obtained from 60 healthy women and 51 women who were bacterial vaginosis (BV) positive. Concentrations of IL-8 and IL-1beta were highly correlated with counts of neutrophils in vaginal fluid of the entire population examined (111 subjects). Vaginal IL-1beta concentrations were significantly higher (P0.001) in BV positive women. There was no significant difference in IL-8 levels or number of neutrophils between healthy controls and BV positive women. None of the healthy controls with high neutrophil counts (or =75th percentile, 14 average count per field) had high concentrations of IL-1beta (or =75th percentile, 220 pg/ml), whereas 84% of BV positive women with high neutrophil counts had high IL-1beta concentrations (P0.001). On the contrary, no difference in the percentage of subjects with elevated concentrations of IL-8 (or =75th percentile, 2842 pg/ml) was found between healthy and BV positive women with high numbers of neutrophils (55.5% of healthy versus 53% of BV positive women). Our findings show that BV causes a large increase in IL-1beta concentrations which is not paralleled by an increase in IL-8 concentrations in vaginal fluid, suggesting that BV-associated factors more specifically dampen IL-8 rather than IL-1beta. The lack of an increase in IL-8 may explain the absence of an increase in neutrophil numbers in most women exposed to abnormal vaginal colonization (BV).
- Published
- 2003
- Full Text
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22. Assessment of the QoL in Italian menopausal women: comparison between HRT users and non-users
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Genazzani, A. R., Nicolucci, A., Campagnoli, C., Crosignani, P., Nappi, C., Serra, G. B., Bottiglioni, E., Cianci, A., Aloysio, D. D., Sarti, C. D., Gambacciani, M., Monteleone, P., Genazzani, Alessandro, Guaschino, S., Palumbo, G., Petraglia, F., Schonauer, S., Volpe, Annibale, Paolantonio, T. D., Nagni, M., Tempesta, A., Coronel, G. A., Qualità, P. D., Genazzani, Ar, Nicolucci, A, Campagnoli, C, Crosignani, P, Nappi, Carmine, Serra, Gb, Bottiglioni, E, Cianci, A, De Aloysio, D, Donati Sarti, C, Gambacciani, M, Monteleone, P, Genazzani, Ad, Guaschino, S, Palumbo, G, Petraglia, F, Schonauer, S, Volpe, A, Di Paolantonio, T, Nagni, M, Tempesta, A, and Coronel, Ga
- Subjects
Gerontology ,medicine.medical_specialty ,Multivariate analysis ,Psychometrics ,HRT ,Health Status ,General Biochemistry, Genetics and Molecular Biology ,Quality of life ,Surveys and Questionnaires ,Epidemiology ,Humans ,Medicine ,Gynecology ,Response rate (survey) ,business.industry ,Public health ,Estrogen Replacement Therapy ,Female ,Italy ,Menopause ,Middle Aged ,Multivariate Analysis ,Quality of Life ,Questionnaires ,Socioeconomic Factors ,Obstetrics and Gynecology ,medicine.disease ,Anxiety ,sense organs ,medicine.symptom ,business - Abstract
Objectives: The aim of this cross-sectional study was to describe QoL in a large sample of women attending menopause centres and compare untreated postmenopausal women and matched HRT users by employing the Women's Health Questionnaire (WHQ) and two generic instruments, the SF-36 and the EQ-5D. Methods: Overall, 2906 women were recruited by 64 menopause centres throughout Italy, of whom 2160 filled in the questionnaire (1093 on HRT and 1067 not on HRT; response rate: 74%). Results: HRT users tended to be younger, healthier and with shorter menopause duration as opposed to non users, while no major socio-economic differences were present. At multivariate analysis, the presence of chronic diseases, low socio-economic status and living in Southern Italy represented the most important predictors of poor QoL. Furthermore, HRT users showed a lower probability of reporting problems in usual activities and pain/discomfort (EQ-5D), role limitations due to emotional problems (SF-36) and anxiety/fears (WHQ). HRT users also showed highly significant better outcomes in those areas that are more directly attributable to hormonal changes of mid age, namely vasomotor symptoms and sexual problems. Conclusions: Although QoL is mainly influenced by socio-economic and cultural factors, HRT has the potential for improving not only symptoms, but also more general aspects of physical and psychological well-being of symptomatic postmenopausal women.
- Published
- 2002
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23. Prevalence of bacterial vaginosis and vaginal flora changes in peri- and postmenopausal women
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Paolo Lanzafame, Francesco De Seta, Sabina Cauci, Davide De Santo, Secondo Guaschino, Silvia Driussi, Teresa Iannicelli, Franco Quadrifoglio, Paola Penacchioni, Domenico De Aloysio, Cauci, S, Driussi, S, DE SANTO, D, Penacchioni, P, Iannicelli, T, Lanzafame, P, DE SETA, Francesco, Quadrifoglio, F, DE ALOYSIO, D, and Guaschino, Secondo
- Subjects
Adult ,Microbiology (medical) ,medicine.medical_specialty ,Epidemiology ,medicine.medical_treatment ,Vaginal disease ,Prevalence ,medicine ,Humans ,Aged ,Climacteric ,Vaginitis ,Gynecology ,Bacteriological Techniques ,business.industry ,Vaginal flora ,Estrogen Replacement Therapy ,Hormone replacement therapy (menopause) ,Vaginosis, Bacterial ,Middle Aged ,medicine.disease ,Postmenopause ,Menopause ,Lactobacillus ,medicine.anatomical_structure ,Vagina ,Female ,Nugent score ,Bacterial vaginosis ,business - Abstract
Our aim was to evaluate the prevalence of bacterial vaginosis and decrease in lactobacillus colonization in women 40 years old or older in relation to menopausal status by evaluation of Gram-stained smears. A total of 1,486 smears from Italian Caucasian women aged 40 to 79 years were examined. Women were classified as follows: fertile (regular cycles) ( n = 328), perimenopausal (irregular cycles) ( n = 237), and postmenopausal ( n = 921), including 331 women on estroprogestinic hormone replacement therapy (HRT). The prevalences of bacterial vaginosis (assessed as a Nugent score of ≥7) in fertile (9.8%) and perimenopausal (11.0%) women were not statistically different, whereas the prevalence was significantly lower overall in postmenopausal women (6.0%) ( P = 0.02). Specifically, 6.3% of postmenopausal women without HRT and 5.4% of postmenopausal women with HRT were positive for bacterial vaginosis. The Nugent score system was not adequate for evaluating the normal and intermediate vaginal flora in women over the age of 40 years. High numbers of peri- and postmenopausal women had no lactobacilli and no bacterial-vaginosis-associated microorganisms. This nonpathological absence of lactobacilli in women with a Nugent score of 4 was scored as 4∗, and this group was considered separately from the intermediate flora group. A score of 4∗ was obtained for 2.1% of fertile women, 11.4% of perimenopausal women, 44.1% of postmenopausal women without HRT, and 6.9% of postmenopausal women with HRT. The physiological reduction in lactobacillus colonization of the vagina in postmenopausal women does not cause an increase in bacterial-vaginosis prevalence. Reversion of lactobacillus flora to premenopausal levels due to HRT does not increase the prevalence of bacterial vaginosis in postmenopausal women.
- Published
- 2002
24. Cardiovascular risk in normal weight, eumenorrheic, nonhirsute daughters of patients with polycystic ovary syndrome: a pilot study.
- Author
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Battaglia C, Mancini F, Cianciosi A, Busacchi P, Persico N, Paradisi R, Facchinetti F, and de Aloysio D
- Subjects
- Blood Flow Velocity, Blood Pressure Monitoring, Ambulatory, Body Weight, Brachial Artery diagnostic imaging, Brachial Artery physiopathology, Cardiovascular Diseases physiopathology, Female, Humans, Menstruation physiology, Mothers, Ovary diagnostic imaging, Pilot Projects, Prospective Studies, Reference Values, Risk Factors, Ultrasonography, Uterus diagnostic imaging, Vasodilation, Cardiovascular Diseases epidemiology, Polycystic Ovary Syndrome genetics
- Abstract
Objective: To verify whether healthy daughters with polycystic ovaries (PCO) of patients with polycystic ovary syndrome (PCOS) have an increased risk of cardiovascular disease in comparison with healthy controls., Design: Prospective observational study., Setting: University hospital., Patient(s): Seventeen eumenorrheic daughters with PCO of patients with PCOS (group 1) and 20 healthy volunteers (group 2) with regular ovulatory cycles., Intervention(s): Fasting blood sampling, ultrasonographic and Doppler analyses, 24-hour ambulatory blood pressure monitoring., Main Outcome Measure(s): Medical examination; blood measurement of nitrites and nitrates, biochemical and hormonal parameters; utero-ovarian ultrasonographic analysis and color Doppler evaluation of uterine and stromal ovarian arteries; brachial artery flow-mediated vasodilatation; 24-hour ambulatory blood pressure monitoring. An oral glucose tolerance test was performed to analyze glucose, insulin, and C-peptide levels., Result(s): At Doppler analysis a significantly higher uterine and a lower ovarian artery pulsatility index was found in group 1 compared with group 2. The brachial artery diameter, after the reactive hyperemia, showed a greater vasodilatation in controls in comparison with women with PCO. The 24-hour blood pressure monitoring demonstrated that patients with PCO have significant higher 24-hour, daytime, and nighttime diastolic and mean arterial pressure values than controls. The nitrites and nitrates plasma levels were lower in group 1 compared with group 2. The glucose and insulin plasma values were higher in patients with PCO than in controls., Conclusion(s): Eumenorrheic nonhirsute daughters of patients with PCOS who have PCO appearance on ultrasound have an increased cardiovascular risk.
- Published
- 2009
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25. Endothelial function and its relationship to leptin, homocysteine, and insulin resistance in lean and overweight eumenorrheic women and PCOS patients: a pilot study.
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Mancini F, Cianciosi A, Reggiani GM, Facchinetti F, Battaglia C, and de Aloysio D
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- Adult, Androgens blood, Blood Flow Velocity, Brachial Artery physiology, Case-Control Studies, Endothelin-1 blood, Female, Fibrinogen metabolism, Humans, Insulin blood, Overweight blood, Polycystic Ovary Syndrome blood, Progesterone blood, Vasodilation, Young Adult, Brachial Artery physiopathology, Endothelium, Vascular physiopathology, Homocysteine blood, Insulin Resistance, Leptin blood, Menstruation physiology, Overweight physiopathology, Polycystic Ovary Syndrome physiopathology
- Abstract
Objective: To verify if patients with polycystic ovarian syndrome (PCOS), have an increased cardiovascular risk compared with healthy controls., Design: Prospective case-control study., Setting: University-based practice., Patient(s): Twenty eumenorrheic controls (ten lean [group A] and ten overweight [group B]) and 24 PCOS women (14 lean [group C] and ten overweight [group D])., Intervention(s): Cardiovascular risk markers and hormonal parameters were assessed., Main Outcome Measure(s): Androgens, fasting glucose, insulin, leptin, fibrinogen, homocysteine, endothelin-1 and flow-mediated dilatation of the brachial artery were measured to investigate their relationship to weight and to PCOS., Result(s): The brachial artery diameter and the pulsatility index, after the reactive hyperemia, showed in group A the most intense vasodilatation compared with the other groups. Homocysteine levels did not differ among the groups. Endothelin-1 was significantly higher in group A compared with groups B and D. Leptin was significantly lower in groups A and C compared with groups B and D. Insulin resistance was higher in groups B and D. Group A had significantly higher glucose-insulin ratio compared with all of the other groups; group C had significantly higher glucose-insulin ratio only compared with group D., Conclusion(s): Weight and PCOS are two independent variables affecting the endothelial function.
- Published
- 2009
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26. Utero-ovarian ultrasonographic and Doppler flow analyses in female childhood cancer survivors with regular menstruation and normal circulating follicle-stimulating hormone levels.
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Battaglia C, Pasini A, Mancini F, Persico N, Burnelli R, Cicognani A, and de Aloysio D
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- Arteries physiopathology, Child, Child, Preschool, Female, Follicle Stimulating Hormone blood, Humans, Infant, Menstruation, Neoplasms physiopathology, Ovulation, Prospective Studies, Vascular Resistance, Neoplasms therapy, Ovary blood supply, Ovary diagnostic imaging, Survivors, Ultrasonography, Doppler, Color, Uterus blood supply, Uterus diagnostic imaging
- Abstract
Objective: To analyze the hormonal, ultrasonographic, and color Doppler parameters in a population-based follow-up study of female childhood cancer survivors with regular menstrual cycle and normal early follicular FSH values., Design: Controlled, prospective clinical study., Setting: University hospital., Patient(s): Twenty-eight female patients affected by a malignant tumor during childhood and 14 age-matched healthy controls., Intervention(s): Hormonal, ultrasonographic, and color Doppler analyses., Main Outcome Measure(s): In the midluteal phase of the cycle, the patients underwent hormonal assay of gonadotropins, E2, and P; ultrasonographic evaluation of the uterine and ovarian volume, the endometrial thickness, and of the corpus luteum characteristics; color Doppler analysis of uterine, intraovarian, and periluteal arteries., Result(s): A greater uterine volume and a better utero-ovarian vascularization was observed in controls in comparison with cancer survivors. In patients who suffered from childhood malignancies the P values were lower than in controls. On the basis of circulating P (> or < 20 nmol/L) values, we divided the former group in ovulatory and nonovulatory patients. We observed that even if there were no differences between ovulatory cancer survivors and controls, the nonovulatory group showed a reduced uterine volume associated with elevated resistance at the level of uterine and intraovarian arteries. Among these two groups the time elapsed between the diagnosis of cancer and menarche was shorter in nonovulatory than in ovulatory women, and was directly correlated with both uterine volume (r = 0.660) and ovarian volume (r = 0.597)., Conclusion(s): Ultrasonographic and Doppler analyses may noninvasively study the subtle utero-ovarian modification after anticancer therapies.
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- 2006
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27. Season of birth influences the timing of menopause.
- Author
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Cagnacci A, Pansini FS, Bacchi-Modena A, Giulini N, Mollica G, De Aloysio D, Vadora E, and Volpe A
- Subjects
- Age Factors, Female, Fertility, Humans, Infant, Newborn, Linear Models, Middle Aged, Retrospective Studies, Menopause, Parturition, Seasons
- Abstract
Background: Seasons may influence prenatal growth and future fertility. This study investigated whether season and month of birth influenced the timing of menopause in a group of women attending three Italian menopause clinics., Methods and Results: Age at menopause of 2822 post-menopausal women (>12 months of amenorrhoea) was stratified by month and season of birth. Mean age at menopause was 49.42 years (SEM: 0.78 years). Menopause occurred earlier for women born in the spring (age 49.04+/-0.15 years) than in the autumn (49.97+/-0.14 years). The earliest menopause was found in women born in March (48.9+/-0.25 years) and the latest in women born in October (50.3+/-0.25 years). The effect of season of birth on age at menopause remained even when considering factors that in our analysis were capable of significantly interfering with the timing of menopause, such as age at menarche, body mass index, smoking habit, level of education and type of job., Conclusions: Taking into consideration the retrospective design of the study, and a possible recall bias, the present data seem to suggest that environmental factors linked to seasons are capable of interfering with the timing of a woman's ovarian exhaustion by an action exerted in the prenatal period.
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- 2005
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28. Role of intratesticular ultrasonographic and Doppler flow analyses in evaluating gonadal status in male survivors of childhood malignancy.
- Author
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Battaglia C, Pasini A, Mancini F, Burnelli R, Cicognani A, and de Aloysio D
- Subjects
- Adolescent, Adult, Follicle Stimulating Hormone blood, Humans, Male, Neoplasms blood, Neoplasms therapy, Neoplasms diagnostic imaging, Survivors, Testis diagnostic imaging, Testis pathology, Ultrasonography, Doppler, Color methods
- Abstract
Fifty-seven males, previously treated for malignancies in childhood, and who refused to masturbate for semen analysis, were submitted to hormonal, ultrasonographic, and Doppler evaluation to assess the effects of chemotherapy/radiotherapy on gonadal function. Nineteen normal healthy fertile males served as controls. In the studied population, FSH was inversely correlated with testicular volume and directly correlated with testicular vascularization, suggesting that ultrasonographic and color Doppler scanning of the testes may be used, if a sperm count is not available, to indirectly assess the gonadal function.
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- 2005
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29. Is total laparoscopic surgery for endometrial carcinoma at risk of local recurrence? A long-term survival.
- Author
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Seracchioli R, Venturoli S, Ceccarin M, Cantarelli M, Ceccaroni M, Pignotti E, De Aloysio D, and De Iaco P
- Subjects
- Adult, Aged, Aged, 80 and over, Disease-Free Survival, Female, Follow-Up Studies, Humans, Hysterectomy adverse effects, Hysterectomy methods, Laparoscopy adverse effects, Laparoscopy methods, Lymph Node Excision adverse effects, Lymph Node Excision methods, Middle Aged, Neoplasm Recurrence, Local, Risk Factors, Survival Rate, Treatment Outcome, Endometrial Neoplasms surgery
- Abstract
Background: Loco-regional recurrences after laparotomic surgery for early endometrial carcinoma have an incidence of 3-8%. This study examined the pattern of recurrences and survival after full laparoscopic hysterectomy., Patients and Methods: Between January 1997 and December 2002, 113 consecutive patients with pre-operative Stage I endometrial cancer, self-referred to two different surgical teams, were treated by the laparoscopic approach by one team and by the laparotomic approach by the other team., Results: Nineteen patients were treated by total laparoscopic hysterectomy (TLH) by the endoscopic group, and 94 were treated by total abdominal hysterectomy (TAH) by the oncologic group. Sixteen patients (84.2%) in the laparoscopic group and 79 patients (84.0%) in the laparotomic group had Stage I disease. The mean age and mean weight did not differ in the two groups. With a mean follow-up of 52.2 months for the TLH group and 43.6 months for the TAH group, one recurrence (5.3%) was observed in the former group and 9 recurrences (10.6%) in the latter group. No significative differences were observed for disease-free survival and overall survival., Conclusion: Total laparoscopic hysterectomy does not increase the risk of local recurrence and does not affect survival for patients with early stage endometrial carcinoma.
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- 2005
30. Influence of multiple transrectal electroejaculations on semen parameters and intracytoplasmic sperm injection outcome.
- Author
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Giulini S, Pesce F, Madgar I, Marsella T, Volpe A, de Aloysio D, and Battaglia C
- Subjects
- Adult, Electric Stimulation, Female, Humans, Male, Middle Aged, Pregnancy, Rectum, Sperm Count, Sperm Motility, Ejaculation, Fertilization, Pregnancy Rate, Sperm Injections, Intracytoplasmic, Spermatozoa cytology, Spermatozoa physiology
- Abstract
Objective: To compare semen parameters and intracytoplasmic sperm injection (ICSI) outcome in spinal cord-injured subjects who underwent single (group 1) or multiple (group 2) electroejaculations before ICSI., Design: Prospective, randomized, controlled study., Setting: Department of gynecology, obstetrics, and pediatric science in a reproductive medicine unit at a major Italian university., Patient(s): Thirty-four healthy women with a male partner with SCI who were seeking assisted reproduction services., Intervention(s): Transrectal electroejaculation, controlled ovarian hyperstimulation, and ICSI., Main Outcome Measure(s): Sperm concentration, morphology, and motility and fertilization and pregnancy rates after ICSI., Result(s): Sperm was successfully retrieved in 94.1% of cases. In male subjects who underwent multiple electroejaculations, statistically significant improvements in sperm concentration and total sperm motility rate were observed. The overall fertilization rate was 63.6%. The number of oocytes retrieved and injected was comparable between the two groups. A total of nine clinical pregnancies were achieved. The pregnancy rate was statistically significantly higher in group 2 (n = 6/16; 37.5%) than in group 1 (n = 3/16; 18.75%)., Conclusion(s): These data suggest that multiple electroejaculation has a positive effect on semen parameters and ICSI outcome.
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- 2004
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31. Interrelationships of interleukin-8 with interleukin-1beta and neutrophils in vaginal fluid of healthy and bacterial vaginosis positive women.
- Author
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Cauci S, Guaschino S, De Aloysio D, Driussi S, De Santo D, Penacchioni P, and Quadrifoglio F
- Subjects
- Female, Humans, Leukocyte Count, Reference Values, Interleukin-1 blood, Interleukin-8 blood, Neutrophils immunology, Vagina immunology, Vagina metabolism, Vaginosis, Bacterial immunology
- Abstract
Vaginal innate immunity in response to microbial perturbation is still poorly understood and could be crucial for protection from adverse outcomes. We investigated the relationship between interleukin (IL)-8, IL-1beta and neutrophils in vaginal fluid obtained from 60 healthy women and 51 women who were bacterial vaginosis (BV) positive. Concentrations of IL-8 and IL-1beta were highly correlated with counts of neutrophils in vaginal fluid of the entire population examined (111 subjects). Vaginal IL-1beta concentrations were significantly higher (P < 0.001) in BV positive women. There was no significant difference in IL-8 levels or number of neutrophils between healthy controls and BV positive women. None of the healthy controls with high neutrophil counts (> or =75th percentile, 14 average count per field) had high concentrations of IL-1beta (> or =75th percentile, 220 pg/ml), whereas 84% of BV positive women with high neutrophil counts had high IL-1beta concentrations (P < 0.001). On the contrary, no difference in the percentage of subjects with elevated concentrations of IL-8 (> or =75th percentile, 2842 pg/ml) was found between healthy and BV positive women with high numbers of neutrophils (55.5% of healthy versus 53% of BV positive women). Our findings show that BV causes a large increase in IL-1beta concentrations which is not paralleled by an increase in IL-8 concentrations in vaginal fluid, suggesting that BV-associated factors more specifically dampen IL-8 rather than IL-1beta. The lack of an increase in IL-8 may explain the absence of an increase in neutrophil numbers in most women exposed to abnormal vaginal colonization (BV).
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- 2003
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32. Prevalence of bacterial vaginosis and vaginal flora changes in peri- and postmenopausal women.
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Cauci S, Driussi S, De Santo D, Penacchioni P, Iannicelli T, Lanzafame P, De Seta F, Quadrifoglio F, de Aloysio D, and Guaschino S
- Subjects
- Adult, Aged, Bacteriological Techniques, Estrogen Replacement Therapy, Female, Humans, Lactobacillus growth & development, Middle Aged, Prevalence, Vaginosis, Bacterial microbiology, Climacteric, Lactobacillus isolation & purification, Postmenopause, Vagina microbiology, Vaginosis, Bacterial epidemiology
- Abstract
Our aim was to evaluate the prevalence of bacterial vaginosis and decrease in lactobacillus colonization in women 40 years old or older in relation to menopausal status by evaluation of Gram-stained smears. A total of 1,486 smears from Italian Caucasian women aged 40 to 79 years were examined. Women were classified as follows: fertile (regular cycles) (n = 328), perimenopausal (irregular cycles) (n = 237), and postmenopausal (n = 921), including 331 women on estroprogestinic hormone replacement therapy (HRT). The prevalences of bacterial vaginosis (assessed as a Nugent score of >or=7) in fertile (9.8%) and perimenopausal (11.0%) women were not statistically different, whereas the prevalence was significantly lower overall in postmenopausal women (6.0%) (P = 0.02). Specifically, 6.3% of postmenopausal women without HRT and 5.4% of postmenopausal women with HRT were positive for bacterial vaginosis. The Nugent score system was not adequate for evaluating the normal and intermediate vaginal flora in women over the age of 40 years. High numbers of peri- and postmenopausal women had no lactobacilli and no bacterial-vaginosis-associated microorganisms. This nonpathological absence of lactobacilli in women with a Nugent score of 4 was scored as 4*, and this group was considered separately from the intermediate flora group. A score of 4* was obtained for 2.1% of fertile women, 11.4% of perimenopausal women, 44.1% of postmenopausal women without HRT, and 6.9% of postmenopausal women with HRT. The physiological reduction in lactobacillus colonization of the vagina in postmenopausal women does not cause an increase in bacterial-vaginosis prevalence. Reversion of lactobacillus flora to premenopausal levels due to HRT does not increase the prevalence of bacterial vaginosis in postmenopausal women.
- Published
- 2002
- Full Text
- View/download PDF
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