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Background: Major depressive disorder is often associated with maladaptive coping strategies, including rumination and thought suppression., Aims: To assess the comparative effect of the selective serotonin reuptake inhibitor escitalopram, and the serotonergic psychedelic psilocybin (COMP360), on rumination and thought suppression in major depressive disorder., Method: Based on data derived from a randomised clinical trial ( N = 59), we performed exploratory analyses on the impact of escitalopram versus psilocybin (i.e. condition) on rumination and thought suppression from 1 week before to 6 weeks after treatment inception (i.e. time), using mixed analysis of variance. Condition responder versus non-responder subgroup analyses were also done, using the standard definition of ≥50% symptom reduction., Results: A time×condition interaction was found for rumination (F(1, 56) = 4.58, P = 0.037) and thought suppression (F(1,57) = 5.88, P = 0.019), with post hoc tests revealing significant decreases exclusively in the psilocybin condition. When analysing via response, a significant time×condition×response interaction for thought suppression (F(1,54) = 8.42, P = 0.005) and a significant time×response interaction for rumination (F(1,54) = 23.50, P < 0.001) were evident. Follow-up tests revealed that decreased thought suppression was exclusive to psilocybin responders, whereas rumination decreased in both responder groups. In the psilocybin arm, decreases in rumination and thought suppression correlated with ego dissolution and session-linked psychological insight., Conclusions: These data provide further evidence on the therapeutic mechanisms of psilocybin and escitalopram in the treatment of depression.

This study aimed to: investigate yielding to the dependent variable "behavioral intent to become a regular blood donor", verify the impact of such communications on variance in the dependent variable, examine the single contribution of the external independent variable to the Rational Action Theory, and test the fit of the expanded Rational Choice Theory to the target behavior and sample. Only a post-test design and double-blinded procedure were used, randomly picking 405 university students for experimental groups 1 and 2, placebo control, and control only. The results showed: lack of yielding by the experimental groups; considerable percentage variance in the dependent variable explained by the independent variable in the experimental and placebo control groups; and satisfactory and significant correlations for variables in the expanded theory. Absence of yielding for the criterion variable was probably due to the time interval. The positive persuasive strategy accounted for the greatest variance in the dependent variable. Moral obligation showed the greatest impact on participants' intent to perform the behavior. The correlations corroborated the theoretical and methodological validity of the expanded theory.