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1. Routine transthoracic echocardiography in ischaemic stroke or transient ischaemic attack of undetermined cause: a prospective multicentre study

Author

van der Maten, Gerlinde, Meijs, Matthijs F. L., Timmer, Jorik R., Brouwers, Paul J. A. M., von Birgelen, Clemens, Coutinho, Jonathan M., Bouma, Berto J., Kerkhoff, Henk, Helming, Anne Mijn, van Tuijl, Julia H., van der Meer, Nicolet A., Saxena, Ritu, Ebink, Corné, van der Palen, Job, and den Hertog, Heleen M.

Published
2024
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2. Outcome Prediction in Cerebral Venous Thrombosis: The IN-REvASC Score.

Author

Klein, Piers, Shu, Liqi, Nguyen, Thanh, Siegler, James, Omran, Setareh, Simpkins, Alexis, Heldner, Mirjam, Havenon, Adam, Aparicio, Hugo, Abdalkader, Mohamad, Psychogios, Marios, Vedovati, Maria, Paciaroni, Maurizio, Martial, Rascha, Liebeskind, David, Sousa, Diana, Coutinho, Jonathan, and Yaghi, Shadi

Subjects
Prognosis, Sinus thrombosis, intracranial, Stroke
Abstract

BACKGROUND: We identified risk factors, derived and validated a prognostic score for poor neurological outcome and death for use in cerebral venous thrombosis (CVT). METHODS: We performed an international multicenter retrospective study including consecutive patients with CVT from January 2015 to December 2020. Demographic, clinical, and radiographic characteristics were collected. Univariable and multivariable logistic regressions were conducted to determine risk factors for poor outcome, mRS 3-6. A prognostic score was derived and validated. RESULTS: A total of 1,025 patients were analyzed with median 375 days (interquartile range [IQR], 180 to 747) of follow-up. The median age was 44 (IQR, 32 to 58) and 62.7% were female. Multivariable analysis revealed the following factors were associated with poor outcome at 90- day follow-up: active cancer (odds ratio [OR], 11.20; 95% confidence interval [CI], 4.62 to 27.14; P

Published
2022

4. Prediction of Outcome and Endovascular Treatment Benefit

Author

Venema, Esmee, Roozenbeek, Bob, Mulder, Maxim JHL, Brown, Scott, Majoie, Charles BLM, Steyerberg, Ewout W, Demchuk, Andrew M, Muir, Keith W, Dávalos, Antoni, Mitchell, Peter J, Bracard, Serge, Berkhemer, Olvert A, Lycklama à Nijeholt, Geert J, van Oostenbrugge, Robert J, Roos, Yvo BWEM, van Zwam, Wim H, van der Lugt, Aad, Hill, Michael D, White, Philip, Campbell, Bruce CV, Guillemin, Francis, Saver, Jeffrey L, Jovin, Tudor G, Goyal, Mayank, Dippel, Diederik WJ, Lingsma, Hester F, der Lugt, Aad van, Boiten, Jelis, Vos, Jan Albert, Jansen, Ivo GH, Goldhoorn, Robert-Jan B, Compagne, Kars CJ, Kappelhof, Manon, Brouwer, Josje, den Hartog, Sanne J, Hinsenveld, Wouter H, van Es, Adriaan CGM, Emmer, Bart J, Coutinho, Jonathan M, Schonewille, Wouter J, Wermer, Marieke JH, van Walderveen, Marianne AA, Staals, Julie, Hofmeijer, Jeannette, Martens, Jasper M, de Bruijn, Sebastiaan F, van Dijk, Lukas C, van der Worp, H Bart, Lo, Rob H, van Dijk, Ewoud J, Boogaarts, Hieronymus D, Vries, J de, de Kort, Paul LM, van Tuijl, Julia, Peluso, Jo P, Fransen, Puck, van den Berg, Jan SP, van Hasselt, Boudewijn AAM, Aerden, Leo AM, Dallinga, René J, Uyttenboogaart, Maarten, Eschgi, Omid, Bokkers, Reinoud PH, Schreuder, Tobien HCML, Heijboer, Roel JJ, Keizer, Koos, Yo, Lonneke SF, den Hertog, Heleen M, Bulut, Tomas, Brouwers, Paul JAM, Sprengers, Marieke ES, Jenniskens, Sjoerd FM, van den Berg, René, Yoo, Albert J, Beenen, Ludo FM, Postma, Alida A, Roosendaal, Stefan D, van der Kallen, Bas FW, van den Wijngaard, Ido R, Bot, Joost, van Doormaal, Pieter-Jan, Meijer, Anton, Ghariq, Elyas, van Proosdij, Marc P, Krietemeijer, G Menno, Lo, Rob, Gerrits, Dick, Dinkelaar, Wouter, and Appelman, Auke PA

Subjects
Clinical Trials and Supportive Activities, Clinical Research, Stroke, Brain Disorders, Neurosciences, Aged, Aged, 80 and over, Brain Ischemia, Endovascular Procedures, Humans, Ischemic Stroke, Male, Middle Aged, Registries, Thrombectomy, Treatment Outcome, ischemic stroke, registry, reperfusion, thrombectomy, uncertainty, HERMES collaborators and MR CLEAN Registry Investigators*, Cardiorespiratory Medicine and Haematology, Clinical Sciences, Neurology & Neurosurgery
Abstract

Background and purposeBenefit of early endovascular treatment (EVT) for ischemic stroke varies considerably among patients. The MR PREDICTS decision tool, derived from MR CLEAN (Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands), predicts outcome and treatment benefit based on baseline characteristics. Our aim was to externally validate and update MR PREDICTS with data from international trials and daily clinical practice.MethodsWe used individual patient data from 6 randomized controlled trials within the HERMES (Highly Effective Reperfusion Evaluated in Multiple Endovascular Stroke Trials) collaboration to validate the original model. Then, we updated the model and performed a second validation with data from the observational MR CLEAN Registry. Primary outcome was functional independence (defined as modified Rankin Scale score 0–2) 3 months after stroke. Treatment benefit was defined as the difference between the probability of functional independence with and without EVT. Discriminative performance was evaluated using a concordance (C) statistic.ResultsWe included 1242 patients from HERMES (633 assigned to EVT, 609 assigned to control) and 3156 patients from the MR CLEAN Registry (all of whom underwent EVT within 6.5 hours). The C-statistic for functional independence was 0.74 (95% CI, 0.72–0.77) in HERMES and, after model updating, 0.80 (0.78–0.82) in the Registry. Median predicted treatment benefit of routinely treated patients (Registry) was 10.3% (interquartile range, 5.8%–14.4%). Patients with low (

Published
2021

6. Effect of Asymptomatic and Symptomatic COVID-19 on Acute Ischemic Stroke Revascularization Outcomes

Author

Strambo, Davide, Marto, João Pedro, Ntaios, George, Nguyen, Thanh N., Michel, Patrik, Herzig, Roman, Członkowksa, Anna, Demeestere, Jelle, Yassin Mansour, Ossama, Georgiopoulos, Georgios, Nogueira, Raul G., Salerno, Alexander, Wegener, Susanne, Baumgartner, Philipp, Cereda, Carlo W., Bianco, Giovanni, Beyeler, Morin, Arnold, Marcel, Carrera, Emmanuel, Machi, Paolo, Altersberger, Valerian, Bonati, Leo, Gensicke, Henrik, Bolognese, Manuel, Peters, Nils, Wetzel, Stephan, Magriço, Marta, Nuno Ramos, João, Sargento-Freitas, João, Machado, Rita, Maia, Carolina, Machado, Egídio, Paiva-Nunes, Ana, Ferreira, Patrícia, Pinho-e-Melo, Teresa, Carvalho-Dias, Mariana, Paula, André, Alberto Correia, Manuel, Castro, Pedro, Azevedo, Elsa, Albuquerque, Luís, Nuno-Alves, José, Ferreira-Pinto, Joana, Meira, Torcato, Pereira, Liliana, Rodrigues, Miguel, Araújo, André, Rodrigues, Marta, Rocha, Mariana, Pereira-Fonseca, Ângelo, Ribeiro, Luís, Varela, Ricardo, Cappellari, Manuel, Zivelonghi, Cecilia, Sajeva, Giulia, Zini, Andrea, Gentile, Mauro, Forlivesi, Stefano, Migliaccio, Ludovica, Sessa, Maria, Pezzini, Alessandro, Sangalli, Davide, Zedde, Marialuisa, Pascarella, Rosario, Diamanti, Susanna, Beretta, Simone, Schwarz, Ghil, Frisullo, Giovanni, Marcheselli, Simona, Seners, Pierre, Sabben, Candice, Escalard, Simon, Piotin, Michel, Maier, Benjamin, Charbonnier, Guillaume, Vuillier, Fabrice, Legris, Loic, Cuisenier, Pauline, Vodret, Francesca R., Marnat, Gaultier, Liegey, Jean-Sebastien, Sibon, Igor, Flottmann, Fabian, Broocks, Gabriel, Gloyer, Nils-Ole, Bohmann, Ferdinand O., Hendrik Schaefer, Jan, Nolte, Christian H., Audebert, Heinrich, Siebert, Eberhard, Sykora, Marek, Lang, Wilfried, Ferrari, Julia, Mayer-Suess, Lukas, Knoflach, Michael, Gizewski, Elke-Ruth, Stolp, Jeffrey, Stolze, Lotte J., Coutinho, Jonathan M., Nederkoorn, Paul J., van-den-Wijngaard, Ido, de Meris, Joke, Lemmens, Robin, De Raedt, Sylvie, Vandervorst, Fenne, Pierre Rutgers, Matthieu, Guilmot, Antoine, Dusart, Anne, Bellante, Flavio, Calleja-Castaño, Patricia, Ostos, Fernando, Gonzalez-Ortega, Guillermo, Martín-Jiménez, Paloma, García-Madrona, Sebastian, Cruz-Culebras, Antonio, Vera, Rocio, Matute, Maria-Consuelo, Fuentes, Blanca, Alonso-de-Leciñana, María, Rigual, Ricardo, Díez-Tejedor, Exuperio, Pérez-Sánchez, Soledad, Montaner, Joan, Díaz-Otero, Fernando, Perez de la Ossa, Natalia, Flores-Pina, Belén, Muñoz-Narbona, Lucia, Chamorro, Angel, Rodríguez-Vázquez, Alejandro, Renú, Arturo, Ayo-Martin, Oscar, Hernandez-Fernandez, Francisco, Segura, Tomas, Tejada-Meza, Herbert, Hlaing, Thant, See, Isaiah, Simister, Robert, Werring, David J., Saxhaug Kristoffersen, Espen, Nordanstig, Annika, Jood, Katarina, Rentzos, Alexandros, Šimůnek, Libor, Krajíčková, Dagmar, Krajina, Antonín, Mikulík, Robert, Cviková, Martina, Vinklárek, Jan, Školoudík, David, Roubec, Martin, Hurtikova, Eva, Hrubý, Rostislav, Ostry, Svatopluk, Skoda, Ondrej, Pernicka, Marek, Kočí, Lubomír, Eichlová, Zuzana, Jíra, Martin, Kovář, Martin, Panský, Michal, Mencl, Pavel, Paloušková, Hana, Tomek, Aleš, Janský, Petr, Olšerová, Anna, Šrámek, Martin, Havlíček, Roman, Malý, Petr, Trakal, Lukáš, Fiksa, Jan, Slovák, Matěj, Karliński, Michał, Nowak, Maciej, Sienkiewicz-Jarosz, Halina, Bochynska, Anna, Wrona, Pawel, Homa, Tomasz, Sawczynska, Katarzyna, Slowik, Agnieszka, Wlodarczyk, Ewa, Wiącek, Marcin, Tomaszewska-Lampart, Izabella, Sieczkowski, Bartosz, Bartosik-Psujek, Halina, Bilik, Marta, Bandzarewicz, Anna, Dorobek, Malgorzata, Zielińska-Turek, Justyna, Nowakowska-Kotas, Marta, Obara, Krystian, Urbanowski, Paweł, Budrewicz, Sławomir, Guziński, Maciej, Świtońska, Milena, Rutkowska, Iwona, Sobieszak-Skura, Paulina, Łabuz-Roszak, Beata, Dębiec, Aleksander, Staszewski, Jacek, Stępień, Adam, Zwiernik, Jacek, Wasilewski, Grzegorz, Tiu, Cristina, Terecoasă, Elena-Oana, Radu, Razvan-Alexandru, Negrila, Anca, Dorobat, Bogdan, Panea, Cristina, Tiu, Vlad, Petrescu, Simona, Özcan-Özdemir, Atilla, Mahmoud, Mostafa, El-Samahy, Hussam, Abdelkhalek, Hazem, Al-Hashel, Jasem, Ibrahim Ismail, Ismail, Salmeen, Athari, Ghoreishi, Abdoreza, Sabetay, Sergiu, Gross, Hana, Klein, Piers, Abdalkader, Mohamad, Jabbour, Pascal, El Naamani, Kareem, Tjoumakaris, Stavropoula, Abbas, Rawad, Mohamed, Ghada-A., Chebl, Alex, Min, Jiangyong, Hovingh, Majesta, Tsai, Jenny, Khan, Muhib-A., Nalleballe, Krishna, Onteddu, Sanjeeva, Masoud, Hesham E., Michael, Mina, Kaur, Navreet, Maali, Laith, Abraham, Michael, Khandelwal, Priyank, Bach, Ivo, Ong, Melody, Babici, Denis, Khawaja, Ayaz-M., Hakemi, Maryam, Rajamani, Kumar, Cano-Nigenda, Vanessa, Arauz, Antonio, Amaya, Pablo, Llanos, Natalia, Arango, Akemi, Vences, Miguel A., Barrientos, José-Domingo, Caetano, Rayllene, Targa, Rodrigo, Scollo, Sergio, Yalung, Patrick, Nagendra, Shashank, Gaikwad, Abhijit, and Seo, Kwon-Duk

Published
2024
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8. Prognostic Value of Thrombus Volume and Interaction With First-Line Endovascular Treatment Device Choice

Author

van Voorst, Henk, Bruggeman, Agnetha A.E., Andriessen, Jurr, Hoving, Jan W., Konduri, Praneeta R., Yang, Wenjin, Kappelhof, Manon, Arrarte Terreros, Nerea, Roos, Yvo B.W.E.M., van Zwam, Wim H., van der Lugt, Aad, van der Hoorn, Anouk, Boiten, Jelis, Roosendaal, Stefan, Jenniskens, Sjoerd, Caan, Matthan W.A., Marquering, Henk A., Emmer, Bart J., Majoie, Charles B.L.M., Dippel, Diederik W.J., van Oostenbrugge, Robert J., Vos, Jan Albert, Jansen, Ivo G.H., Mulder, Maxim J.H.L., Goldhoorn, Robert- Jan B., Compagne, Kars C.J., Brouwer, Josje, den Hartog, Sanne J., Hinsenveld, Wouter H., Dippel, Diederik W.J., Roozenbeek, Bob, van Es, Adriaan C.G.M., Coutinho, Jonathan M., Schonewille, Wouter J., Vos, Jan Albert, Wermer, Marieke J.H., van Walderveen, Marianne A.A., Staals, Julie, van Oostenbrugge, Robert J., Hofmeijer, Jeannette, Martens, Jasper M., Lycklama à Nijeholt, Geert J., de Bruijn, Sebastiaan F., van Dijk, Lukas C., van der Worp, H. Bart, Lo, Rob H., van Dijk, Ewoud J., Boogaarts, Hieronymus D., de Vries, J., de Kort, Paul L.M., van Tuijl, Julia, Peluso, Jo P., Fransen, Puck, van den Berg, Jan S.P., van Hasselt, Boudewijn A.A.M., Aerden, Leo A.M., Dallinga, René J., Uyttenboogaart, Maarten, Eschgi, Omid, Bokkers, Reinoud P.H., Schreuder, Tobien H.C.M.L., Heijboer, Roel J.J., Keizer, Koos, Yo, Lonneke S.F., den Hertog, Heleen M., Sturm, Emiel J.C., Brouwers, Paul J.A.M., Lycklama à Nijeholt, Geert J., van Walderveen, Marianne A.A., Sprengers, Marieke E.S., van den Berg, René, Yoo, Albert J., Beenen, Ludo F.M., Postma, Alida A., van der Kallen, Bas F.W., van den Wijngaard, Ido R., van Es, Adriaan C.G.M., Martens, Jasper M., Yo, Lonneke S.F., Vos, Jan Albert, Bot, Joost, van Doormaal, Pieter-Jan, Meijer, Anton, Ghariq, Elyas, Bokkers, Reinoud P.H., van Proosdij, Marc P., Krietemeijer, G. Menno, Peluso, Jo P., Boogaarts, Hieronymus D., Lo, Rob, Gerrits, Dick, Dinkelaar, Wouter, Appelman, Auke P.A., Hammer, Bas, Pegge, Sjoert, Vinke, Saman, Dippel, Diederik W.J., van Oostenbrugge, Robert J., Lycklama à Nijeholt, Geert J., Vos, Jan Albert, Schonewille, Wouter J., Hofmeijer, Jeannette, Martens, Jasper M., van der Worp, H. Bart, Lo, Rob H., van Oostenbrugge, Robert J., Hofmeijer, Jeannette, Flach, H. Zwenneke, Lingsma, Hester F., el Ghannouti, Naziha, Sterrenberg, Martin, Pellikaan, Wilma, Sprengers, Rita, Elfrink, Marjan, Simons, Michelle, Vossers, Marjolein, de Meris, Joke, Vermeulen, Tamara, Geerlings, Annet, van Vemde, Gina, Simons, Tiny, Messchendorp, Gert, Nicolaij, Nynke, Bongenaar, Hester, Bodde, Karin, Kleijn, Sandra, Lodico, Jasmijn, Droste, Hanneke, Wollaert, Maureen, Verheesen, Sabrina, Jeurrissen, D., Bos, Erna, Drabbe, Yvonne, Sandiman, Michelle, Aaldering, Nicoline, Zweedijk, Berber, Vervoort, Jocova, Ponjee, Eva, Romviel, Sharon, Kanselaar, Karin, Barning, Denn, Venema, Esmee, Chalos, Vicky, Geuskens, Ralph R., van Straaten, Tim, Ergezen, Saliha, Harmsma, Roger R.M., Muijres, Daan, de Jong, Anouk, Berkhemer, Olvert A., Boers, Anna M.M., Huguet, J., Groot, P.F.C., Mens, Marieke A., van Kranendonk, Katinka R., Treurniet, Kilian M., Tolhuisen, Manon L., Alves, Heitor, Weterings, Annick J., Kirkels, Eleonora L.F., Voogd, Eva J.H.F., Schupp, Lieve M., Collette, Sabine, Groot, Adrien E.D., LeCouffe, Natalie E., Prasetya, Haryadi, and Ramos, Lucas A.

Published
2023
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10. Impact of the lockdown on acute stroke treatments during the first surge of the COVID-19 outbreak in the Netherlands

Author

Benali, Faysal, Stolze, Lotte J., Rozeman, Anouk D., Dinkelaar, Wouter, Coutinho, Jonathan M., Emmer, Bart J., Gons, Rob A. R., Yo, Lonneke F. S., van Tuijl, Julia H., Boukrab, Issam, van Dam-Nolen, Dianne H. K., van den Wijngaard, Ido R., Lycklama à Nijeholt, Geert J., de Laat, Karlijn F., van Dijk, Lukas C., den Hertog, Heleen M., Flach, H. Zwenneke, Wermer, Marieke J. H., van Walderveen, Marianne A. A., Brouwers, Paul J. A. M., Bulut, Tomas, Vermeer, Sarah E., Bernsen, Marie Louise E., Uyttenboogaart, Maarten, Bokkers, Reinoud P. H., Boogaarts, Jeroen D., de Leeuw, Frank-Erik, van der Worp, H. Bart, van der Schaaf, Irene C., Schonewille, Wouter J., Vos, Jan A., Remmers, Michel J. M., Imani, Farshad, Dippel, Diederik W. J., van Zwam, Wim H., Nederkoorn, Paul J., and van Oostenbrugge, Robert J.

Published
2022
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11. Left Atrial Appendage Opacification on Cardiac Computed Tomography in Acute Ischemic Stroke: The Clinical Implications of Slow-Flow.

Author

Shan Sui Nio, Rinkel, Leon A., Cramer, Olivia N., Beyda Özata, Z., Beemsterboer, Chiel F. P., Guglielmi, Valeria, Bouma, Berto J., Matthijs Boekholdt, S., Lobé, Nick H. J., Beenen, Ludo F. M., Marquering, Henk A., Majoie, Charles B. L. M., Roos, Yvo B. W. E. M., van Randen, Adrienne, Nils Planken, R., and Coutinho, Jonathan M.

Published
2024
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14. Improvements in Endovascular Treatment for Acute Ischemic Stroke: A Longitudinal Study in the MR CLEAN Registry

Author

Compagne, Kars C.J., Kappelhof, Manon, Hinsenveld, Wouter H., Brouwer, Josje, Goldhoorn, Robert-Jan B., Uyttenboogaart, Maarten, Bokkers, Reinoud P.H., Schonewille, Wouter J., Martens, Jasper M., Hofmeijer, Jeannette, van der Worp, H. Bart, Lo, Rob T.H., Keizer, Koos, Yo, Lonneke S.F., Lycklama à Nijeholt, Geert J., den Hertog, Heleen M., Sturm, Emiel J.C., Brouwers, Paul J.A.M., van Walderveen, Marianne A.A., Wermer, Marieke J.H., de Bruijn, Sebastiaan F., van Dijk, Lukas C., Boogaarts, Hieronymus D., van Dijk, Ewout J., van Tuijl, Julia H., Peluso, Jo P.P., de Kort, Paul L.M., van Hasselt, Boudewijn A.A.M., Fransen, Puck S., Schreuder, Tobien H.C.M.L., Heijboer, Roel J.J., Jenniskens, Sjoerd F.M., Sprengers, Marieke E.S., Ghariq, Elias, van den Wijngaard, Ido R., Roosendaal, Stefan D., Meijer, Anton F.J.A., Beenen, Ludo F.M., Postma, Alida A., van den Berg, René, Yoo, Albert J., van Doormaal, Pieter Jan, van Proosdij, Marc P., Krietemeijer, Menno G.M., Gerrits, Dick G., Hammer, Sebastiaan, Vos, Jan Albert, Boiten, Jelis, Coutinho, Jonathan M., Emmer, Bart J., van Es, Ad C.G.M., Roozenbeek, Bob, Roos, Yvo B.W.E.M., van Zwam, Wim H., van Oostenbrugge, Robert J., Majoie, Charles B.L.M., Dippel, Diederik W.J., and van der Lugt, Aad

Published
2022
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15. Safety and efficacy of rivaroxaban in pediatric cerebral venous thrombosis (EINSTEIN-Jr CVT): for the EINSTEIN-Jr Cerebral Venous Thrombosis trial investigators

Author

Connor, Philip, Sánchez van Kammen, Mayte, Lensing, Anthonie W.A., Chalmers, Elizabeth, Kállay, Krisztián, Hege, Kerry, Simioni, Paolo, Biss, Tina, Bajolle, Fanny, Bonnet, Damien, Grunt, Sebastian, Kumar, Riten, Lvova, Olga, Bhat, Rukhmi, Van Damme, An, Palumbo, Joseph, Santamaria, Amparo, Saracco, Paola, Payne, Jeanette, Baird, Susan, Godder, Kamar, Labarque, Veerle, Male, Christoph, Martinelli, Ida, Morales Soto, Michelle, Motwani, Jayashree, Shah, Sanjay, Hooimeijer, Helene L., Prins, Martin H., Kubitza, Dagmar, Smith, William T., Berkowitz, Scott D., Pap, Akos F., Majumder, Madhurima, Monagle, Paul, and Coutinho, Jonathan M.

Published
2020
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16. Outcomes of Cerebral Venous Thrombosis due to Vaccine-Induced Immune Thrombotic Thrombocytopenia After the Acute Phase

Author

van de Munckhof, Anita, Lindgren, Erik, Kleinig, Timothy J., Field, Thalia S., Cordonnier, Charlotte, Krzywicka, Katarzyna, Poli, Sven, Sánchez van Kammen, Mayte, Borhani-Haghighi, Afshin, Lemmens, Robin, Scutelnic, Adrian, Ciccone, Alfonso, Gattringer, Thomas, Wittstock, Matthias, Dizonno, Vanessa, Devroye, Annemie, Elkady, Ahmed, Günther, Albrecht, Cervera, Alvaro, Mengel, Annerose, Chew, Beng Lim Alvin, Buck, Brian, Zanferrari, Carla, Garcia-Esperon, Carlos, Jacobi, Christian, Soriano, Cristina, Michalski, Dominik, Zamani, Zohreh, Blacquiere, Dylan, Johansson, Elias, Cuadrado-Godia, Elisa, Vuillier, Fabrice, Bode, Felix J., Caparros, François, Maier, Frank, Tsivgoulis, Georgios, Katzberg, Hans D., Duan, Jiangang, Burrow, Jim, Pelz, Johann, Mbroh, Joshua, Oen, Joyce, Schouten, Judith, Zimmermann, Julian, Ng, Karl, Garambois, Katia, Petruzzellis, Marco, Carvalho Dias, Mariana, Ghiasian, Masoud, Romoli, Michele, Miranda, Miguel, Wronski, Miriam, Skjelland, Mona, Almasi-Dooghaee, Mostafa, Cuisenier, Pauline, Murphy, Seán, Timsit, Serge, Coutts, Shelagh B., Schönenberger, Silvia, Nagel, Simon, Hiltunen, Sini, Chatterton, Sophie, Cox, Thomas, Bartsch, Thorsten, Shaygannejad, Vahid, Mirzaasgari, Zahra, Middeldorp, Saskia, Levi, Marcel M., Kremer Hovinga, Johanna A., Jood, Katarina, Tatlisumak, Turgut, Putaala, Jukka, Heldner, Mirjam R., Arnold, Marcel, Aguiar de Sousa, Diana, Ferro, José M., and Coutinho, Jonathan M.

Published
2022
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17. Thrombus Imaging Characteristics to Predict Early Recanalization in Anterior Circulation Large Vessel Occlusion Stroke

Author

Arrarte Terreros, Nerea, primary, Stolp, Jeffrey, additional, Bruggeman, Agnetha A. E., additional, Swijnenburg, Isabella S. J., additional, Lopes, Ricardo R., additional, van Meenen, Laura C. C., additional, Groot, Adrien E. D., additional, Kappelhof, Manon, additional, Coutinho, Jonathan M., additional, Roos, Yvo B. W. E. M., additional, Emmer, Bart J., additional, Beenen, Ludo F. M., additional, Dippel, Diederik W. J., additional, van Zwam, Wim H., additional, van Bavel, Ed, additional, Marquering, Henk A., additional, and Majoie, Charles B. L. M., additional

Published
2024
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18. Value of Automatically Derived Full Thrombus Characteristics: An Explorative Study of Their Associations with Outcomes in Ischemic Stroke Patients

Author

Mojtahedi, Mahsa, primary, Bruggeman, Agnetha E., additional, van Voorst, Henk, additional, Ponomareva, Elena, additional, Kappelhof, Manon, additional, van der Lugt, Aad, additional, Hoving, Jan W., additional, Dutra, Bruna G., additional, Dippel, Diederik, additional, Cavalcante, Fabiano, additional, Yo, Lonneke, additional, Coutinho, Jonathan, additional, Brouwer, Josje, additional, Treurniet, Kilian, additional, Tolhuisen, Manon L., additional, LeCouffe, Natalie, additional, Arrarte Terreros, Nerea, additional, Konduri, Praneeta R., additional, van Zwam, Wim, additional, Roos, Yvo, additional, Majoie, Charles B. L. M., additional, Emmer, Bart J., additional, and Marquering, Henk A., additional

Published
2024
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19. Endovascular Hypothermia in Acute Ischemic Stroke: Pilot Study of Selective Intra-Arterial Cold Saline Infusion.

Author

Chen, Jian, Liu, Liqiang, Zhang, Hongqi, Geng, Xiaokun, Jiao, Liqun, Li, Guilin, Coutinho, Jonathan, Ding, Yuchuan, Liebeskind, David, and Ji, Xunming

Subjects
endovascular procedures, hypothermia, intra-arterial infusions, neuroprotection, reperfusion injury, Adult, Aged, Brain Ischemia, Cold Temperature, Combined Modality Therapy, Endovascular Procedures, Feasibility Studies, Female, Fibrinolytic Agents, Humans, Hypothermia, Induced, Infusions, Intra-Arterial, Male, Middle Aged, Pilot Projects, Sodium Chloride, Thrombolytic Therapy
Abstract

BACKGROUND AND PURPOSE: We conducted a pilot feasibility and safety study of selective brain cooling with intra-arterial infusion of cold saline combined with endovascular reperfusion for acute ischemic stroke. METHODS: Patients with large-vessel occlusion within 8 hours after symptom onset were enrolled. All patients received intra-arterial recanalization combined with infusion of cold isotonic saline (4°C) in the ischemic territory through the angiographic catheter. RESULTS: Twenty-six patients underwent the procedure, which was technically successful in all. The temperature of ischemic cerebral tissue was decreased by at least 2°C during infusion of the cold solution, and systemic temperature was mildly reduced (maximum 0.3°C). No obvious complications related to intra-arterial hypothermia were observed. CONCLUSIONS: Selective brain cooling by intra-arterial infusion of cold saline combined with endovascular recanalization therapy in acute ischemic stroke seems feasible and safe.

Published
2016

21. Endovascular treatment of patients with stroke caused by anterior cerebral artery occlusions

Author

Neurologen, Brain, Circulatory Health, Stroke, Vos, Erik M., Kappelhof, Manon, den Hartog, Sanne J., Coutinho, Jonathan M., Emmer, Bart J., Roozenbeek, Bob, van Zwam, Wim H., van Oostenbrugge, Robert J., van der Worp, H. Bart, Uyttenboogaart, Maarten, van Es, Adriaan C.G.M., Majoie, Charles B.L.M., Dippel, Diederik W.J., Peeters-Scholte, Cacha M.P.C.D., van den Wijngaard, Ido R., Neurologen, Brain, Circulatory Health, Stroke, Vos, Erik M., Kappelhof, Manon, den Hartog, Sanne J., Coutinho, Jonathan M., Emmer, Bart J., Roozenbeek, Bob, van Zwam, Wim H., van Oostenbrugge, Robert J., van der Worp, H. Bart, Uyttenboogaart, Maarten, van Es, Adriaan C.G.M., Majoie, Charles B.L.M., Dippel, Diederik W.J., Peeters-Scholte, Cacha M.P.C.D., and van den Wijngaard, Ido R.

Published
2024

22. Coma in adult cerebral venous thrombosis: The BEAST study

Author

Neurologen, Brain, Circulatory Health, Ranjan, Redoy, Ken-Dror, Gie, Martinelli, Ida, Grandone, Elvira, Hiltunen, Sini, Lindgren, Erik, Margaglione, Maurizio, Duchez, Veronique Le Cam, Triquenot Bagan, Aude, Zedde, Marialuisa, Giannini, Nicola, Ruigrok, Ynte M., Worrall, Bradford B., Majersik, Jennifer J., Putaala, Jukka, Haapaniemi, Elena, Zuurbier, Susanna M., Brouwer, Matthijs C., Passamonti, Serena M., Abbattista, Maria, Bucciarelli, Paolo, Lemmens, Robin, Pappalardo, Emanuela, Costa, Paolo, Colombi, Marina, Aguiar de Sousa, Diana, Rodrigues, Sofia, Canhão, Patrícia, Tkach, Aleksander, Santacroce, Rosa, Favuzzi, Giovanni, Arauz, Antonio, Colaizzo, Donatella, Spengos, Kostas, Hodge, Amanda, Ditta, Reina, Pezzini, Alessandro, Coutinho, Jonathan M., Thijs, Vincent, Jood, Katarina, Tatlisumak, Turgut, Ferro, José M., Sharma, Pankaj, Neurologen, Brain, Circulatory Health, Ranjan, Redoy, Ken-Dror, Gie, Martinelli, Ida, Grandone, Elvira, Hiltunen, Sini, Lindgren, Erik, Margaglione, Maurizio, Duchez, Veronique Le Cam, Triquenot Bagan, Aude, Zedde, Marialuisa, Giannini, Nicola, Ruigrok, Ynte M., Worrall, Bradford B., Majersik, Jennifer J., Putaala, Jukka, Haapaniemi, Elena, Zuurbier, Susanna M., Brouwer, Matthijs C., Passamonti, Serena M., Abbattista, Maria, Bucciarelli, Paolo, Lemmens, Robin, Pappalardo, Emanuela, Costa, Paolo, Colombi, Marina, Aguiar de Sousa, Diana, Rodrigues, Sofia, Canhão, Patrícia, Tkach, Aleksander, Santacroce, Rosa, Favuzzi, Giovanni, Arauz, Antonio, Colaizzo, Donatella, Spengos, Kostas, Hodge, Amanda, Ditta, Reina, Pezzini, Alessandro, Coutinho, Jonathan M., Thijs, Vincent, Jood, Katarina, Tatlisumak, Turgut, Ferro, José M., and Sharma, Pankaj

Published
2024

23. Gene-Gene Interaction Between Factor-XI and ABO Genes in Cerebral Venous Thrombosis: The BEAST Study

Author

Neurologen, Brain, Circulatory Health, Ken-Dror, Gie, Martinelli, Ida, Grandone, Elvira, Hiltunen, Sini, Lindgren, Erik, Margaglione, Maurizio, Le Cam Duchez, Veronique, Triquenot, Aude B., Zedde, Marialuisa, Mancuso, Michelangelo, Ruigrok, Ynte M., Worrall, Bradford B., Majersik, Jennifer J., Putaala, Jukka, Haapaniemi, Elena, Zuurbier, Susanna, Brouwer, Matthijs C., Passamonti, Serena M., Abbattista, Maria, Bucciarelli, Paolo, Lemmens, Robin, Pappalardo, Emanuela, Costa, Paolo, Colombi, Marina, De Sousa, Diana Aguiar, Rodrigues, Sofia G., Canhao, Patrícia, Tkach, Aleksander, Santacroce, Rosa, Favuzzi, Giovanni, Arauz, Antonio, Colaizzo, Donatella, Spengos, Konstantinos, Hodge, Amanda, Ditta, Reina, Pezzini, Alessandro, Coutinho, Jonathan M., Thijs, Vincent N., Jood, Katarina, Pare, Guillaume, Tatlisumak, Turgut, Ferro, José M., Sharma, Pankaj, Neurologen, Brain, Circulatory Health, Ken-Dror, Gie, Martinelli, Ida, Grandone, Elvira, Hiltunen, Sini, Lindgren, Erik, Margaglione, Maurizio, Le Cam Duchez, Veronique, Triquenot, Aude B., Zedde, Marialuisa, Mancuso, Michelangelo, Ruigrok, Ynte M., Worrall, Bradford B., Majersik, Jennifer J., Putaala, Jukka, Haapaniemi, Elena, Zuurbier, Susanna, Brouwer, Matthijs C., Passamonti, Serena M., Abbattista, Maria, Bucciarelli, Paolo, Lemmens, Robin, Pappalardo, Emanuela, Costa, Paolo, Colombi, Marina, De Sousa, Diana Aguiar, Rodrigues, Sofia G., Canhao, Patrícia, Tkach, Aleksander, Santacroce, Rosa, Favuzzi, Giovanni, Arauz, Antonio, Colaizzo, Donatella, Spengos, Konstantinos, Hodge, Amanda, Ditta, Reina, Pezzini, Alessandro, Coutinho, Jonathan M., Thijs, Vincent N., Jood, Katarina, Pare, Guillaume, Tatlisumak, Turgut, Ferro, José M., and Sharma, Pankaj

Published
2024

24. Decompressive craniectomy plus best medical treatment versus best medical treatment alone for spontaneous severe deep supratentorial intracerebral haemorrhage: a randomised controlled clinical trial

Author

Neurologen, Brain, Beck, Jürgen, Fung, Christian, Strbian, Daniel, Bütikofer, Lukas, Z'Graggen, Werner J., Lang, Matthias F., Beyeler, Seraina, Gralla, Jan, Ringel, Florian, Schaller, Karl, Plesnila, Nikolaus, Arnold, Marcel, Hacke, Werner, Jüni, Peter, Mendelow, Alexander David, Stapf, Christian, Al-Shahi Salman, Rustam, Bressan, Jenny, Lerch, Stefanie, Hakim, Arsany, Martinez-Majander, Nicolas, Piippo-Karjalainen, Anna, Vajkoczy, Peter, Wolf, Stefan, Schubert, Gerrit A., Höllig, Anke, Veldeman, Michael, Roelz, Roland, Gruber, Andreas, Rauch, Philip, Mielke, Dorothee, Rohde, Veit, Kerz, Thomas, Uhl, Eberhard, Thanasi, Enea, Huttner, Hagen B., Kallmünzer, Bernd, Jaap Kappelle, L., Deinsberger, Wolfgang, Roth, Christian, Lemmens, Robin, Leppert, Jan, Sanmillan, Jose L., Coutinho, Jonathan M., Hackenberg, Katharina A.M., Reimann, Gernot, Mazighi, Mikael, Bassetti, Claudio L.A., Mattle, Heinrich P., Raabe, Andreas, SWITCH study investigators, Neurologen, Brain, Beck, Jürgen, Fung, Christian, Strbian, Daniel, Bütikofer, Lukas, Z'Graggen, Werner J., Lang, Matthias F., Beyeler, Seraina, Gralla, Jan, Ringel, Florian, Schaller, Karl, Plesnila, Nikolaus, Arnold, Marcel, Hacke, Werner, Jüni, Peter, Mendelow, Alexander David, Stapf, Christian, Al-Shahi Salman, Rustam, Bressan, Jenny, Lerch, Stefanie, Hakim, Arsany, Martinez-Majander, Nicolas, Piippo-Karjalainen, Anna, Vajkoczy, Peter, Wolf, Stefan, Schubert, Gerrit A., Höllig, Anke, Veldeman, Michael, Roelz, Roland, Gruber, Andreas, Rauch, Philip, Mielke, Dorothee, Rohde, Veit, Kerz, Thomas, Uhl, Eberhard, Thanasi, Enea, Huttner, Hagen B., Kallmünzer, Bernd, Jaap Kappelle, L., Deinsberger, Wolfgang, Roth, Christian, Lemmens, Robin, Leppert, Jan, Sanmillan, Jose L., Coutinho, Jonathan M., Hackenberg, Katharina A.M., Reimann, Gernot, Mazighi, Mikael, Bassetti, Claudio L.A., Mattle, Heinrich P., Raabe, Andreas, and SWITCH study investigators

Published
2024

25. External validation of the SI2NCAL2C score for outcomes following cerebral venous thrombosis

Author

MS Interne Geneeskunde, Klein, Piers, Shu, Liqi, Lindgren, Erik, de Winter, Maria A., Siegler, James E., Simpkins, Alexis N., Omran, Satareh Salehi, Heldner, Mirjam R., de Havenon, Adam, Abdalkader, Mohamad, al Kasab, Sami, Stretz, Christoph, Wu, Teddy Y., Wilson, Duncan, Asad, Syed Daniyal, Almallouhi, Eyad, Frontera, Jennifer, Kuohn, Lindsey, Rothstein, Aaron, Bakradze, Ekaterina, Henninger, Nils, Zubair, Adeel S., Sharma, Richa, Kerrigan, Deborah, Aziz, Yasmin, Mistry, Eva A., van Kammen, Mayte Sanchez, Tatlisumak, Turgut, Krzywicka, Katarzyna, Aguiar de Sousa, Diana, Jood, Katarina, Field, Thalia S., Yaghi, Shadi, Coutinho, Jonathan M., Nguyen, Thanh N., MS Interne Geneeskunde, Klein, Piers, Shu, Liqi, Lindgren, Erik, de Winter, Maria A., Siegler, James E., Simpkins, Alexis N., Omran, Satareh Salehi, Heldner, Mirjam R., de Havenon, Adam, Abdalkader, Mohamad, al Kasab, Sami, Stretz, Christoph, Wu, Teddy Y., Wilson, Duncan, Asad, Syed Daniyal, Almallouhi, Eyad, Frontera, Jennifer, Kuohn, Lindsey, Rothstein, Aaron, Bakradze, Ekaterina, Henninger, Nils, Zubair, Adeel S., Sharma, Richa, Kerrigan, Deborah, Aziz, Yasmin, Mistry, Eva A., van Kammen, Mayte Sanchez, Tatlisumak, Turgut, Krzywicka, Katarzyna, Aguiar de Sousa, Diana, Jood, Katarina, Field, Thalia S., Yaghi, Shadi, Coutinho, Jonathan M., and Nguyen, Thanh N.

Published
2024

26. Thrombus Imaging Characteristics to Predict Early Recanalization in Anterior Circulation Large Vessel Occlusion Stroke

Author

Arrarte Terreros, Nerea, Stolp, Jeffrey, Bruggeman, Agnetha A.E., Swijnenburg, Isabella S.J., Lopes, Ricardo R., van Meenen, Laura C.C., Groot, Adrien E.D., Kappelhof, Manon, Coutinho, Jonathan M., Roos, Yvo B.W.E.M., Emmer, Bart J., Beenen, Ludo F.M., Dippel, Diederik W.J., van Zwam, Wim H., van Bavel, Ed, Marquering, Henk A., Majoie, Charles B.L.M., Arrarte Terreros, Nerea, Stolp, Jeffrey, Bruggeman, Agnetha A.E., Swijnenburg, Isabella S.J., Lopes, Ricardo R., van Meenen, Laura C.C., Groot, Adrien E.D., Kappelhof, Manon, Coutinho, Jonathan M., Roos, Yvo B.W.E.M., Emmer, Bart J., Beenen, Ludo F.M., Dippel, Diederik W.J., van Zwam, Wim H., van Bavel, Ed, Marquering, Henk A., and Majoie, Charles B.L.M.

Abstract

The early management of transferred patients with a large vessel occlusion (LVO) stroke could be improved by identifying patients who are likely to recanalize early. We aim to predict early recanalization based on patient clinical and thrombus imaging characteristics. We included 81 transferred anterior-circulation LVO patients with an early recanalization, defined as the resolution of the LVO or the migration to a distal location not reachable with endovascular treatment upon repeated radiological imaging. We compared their clinical and imaging characteristics with all (322) transferred patients with a persistent LVO in the MR CLEAN Registry. We measured distance from carotid terminus to thrombus (DT), thrombus length, density, and perviousness on baseline CT images. We built logistic regression models to predict early recanalization. We validated the predictive ability by computing the median area-under-the-curve (AUC) of the receiver operating characteristics curve for 100 5-fold cross-validations. The administration of intravenous thrombolysis (IVT), longer transfer times, more distal occlusions, and shorter, pervious, less dense thrombi were characteristic of early recanalization. After backward elimination, IVT administration, DT and thrombus density remained in the multivariable model, with an AUC of 0.77 (IQR 0.72–0.83). Baseline thrombus imaging characteristics are valuable in predicting early recanalization and can potentially be used to optimize repeated imaging workflow.

Published
2024

27. Endovascular treatment of patients with stroke caused by anterior cerebral artery occlusions

Author

Vos, Erik M., Kappelhof, Manon, den Hartog, Sanne J., Coutinho, Jonathan M., Emmer, Bart J., Roozenbeek, Bob, van Zwam, Wim H., van Oostenbrugge, Robert J., van der Worp, H. Bart, Uyttenboogaart, Maarten, van Es, Adriaan C.G.M., Majoie, Charles B.L.M., Dippel, Diederik W.J., Peeters-Scholte, Cacha M.P.C.D., van den Wijngaard, Ido R., Vos, Erik M., Kappelhof, Manon, den Hartog, Sanne J., Coutinho, Jonathan M., Emmer, Bart J., Roozenbeek, Bob, van Zwam, Wim H., van Oostenbrugge, Robert J., van der Worp, H. Bart, Uyttenboogaart, Maarten, van Es, Adriaan C.G.M., Majoie, Charles B.L.M., Dippel, Diederik W.J., Peeters-Scholte, Cacha M.P.C.D., and van den Wijngaard, Ido R.

Abstract

Background: Occlusion of the anterior cerebral artery (ACA) is uncommon but may lead to significant disability. The benefit of endovascular treatment (EVT) for ACA occlusions remains uncertain. Methods: We included patients treated with EVT and compared patients with ACA occlusions with patients who had internal carotid artery (ICA) or proximal (M1/M2) middle cerebral artery (MCA) occlusions from the MR CLEAN Registry. Primary outcome was the modified Rankin Scale score (mRS). Secondary outcomes were functional independence (mRS 0–2), National Institutes of Health Stroke Scale (NIHSS) score, delta-NIHSS (baseline minus NIHSS score at 24–48 h), and successful recanalization (expanded thrombolysis in cerebral infarction (eTICI) score 2b-3). Safety outcomes were symptomatic intracranial hemorrhage (sICH), periprocedural complications, and mortality. Results: Of 5193 patients, 11 (0.2%) had primary ACA occlusions. Median NIHSS at baseline was lower in patients with ACA versus ICA/MCA occlusions (11, IQR 9–14; versus 15, IQR 11–19). Functional outcome did not differ from patients with ICA/MCA occlusions. Functional independence was 4/11 (36%) in patients with ACA versus 1949/4815 (41%) in ICA/MCA occlusions; median delta-NIHSS was − 1 (IQR − 7 to 2) and − 4 (IQR − 9 to 0), respectively. Successful recanalization was 4/9 (44%), versus 3083/4787 (64%) in ICA/MCA occlusions. Mortality was 3/11 (27%) versus 1263/4815 (26%). One patient with ACA occlusion had sICH; no other complications occurred. Conclusion: In this cohort ACA occlusions were uncommon. Functional outcome did not differ between patients with ACA occlusions and ICA/MCA occlusions. Prospective research is needed to determine feasibility, safety, and outcomes of EVT for ACA occlusions.

Published
2024

28. Neurological phenotype of adenosine deaminase 2 deficient patients: a cohort study

Author

MS Reumatologie/Immunologie/Infectie, Infection & Immunity, Reumatologie, Cluster B, Immuno/reuma patientenzorg, Child Health, Verschoof, Merelijne A, van Meenen, Laura C C, Andriessen, M Valérie E, Brinkman, Daniëlle M C, Kamphuis, Sylvia, Kuijpers, Taco W, Leavis, Helen L, Legger, G Elizabeth, Mulders-Manders, Catharina M, de Pagter, Anne P J, Rutgers, Abraham, van Well, Gijs T J, Coutinho, Jonathan M, Hak, A Elisabeth, van Montfrans, Joris M, Klouwer, Femke C C, MS Reumatologie/Immunologie/Infectie, Infection & Immunity, Reumatologie, Cluster B, Immuno/reuma patientenzorg, Child Health, Verschoof, Merelijne A, van Meenen, Laura C C, Andriessen, M Valérie E, Brinkman, Daniëlle M C, Kamphuis, Sylvia, Kuijpers, Taco W, Leavis, Helen L, Legger, G Elizabeth, Mulders-Manders, Catharina M, de Pagter, Anne P J, Rutgers, Abraham, van Well, Gijs T J, Coutinho, Jonathan M, Hak, A Elisabeth, van Montfrans, Joris M, and Klouwer, Femke C C

Published
2024

29. Value of Automatically Derived Full Thrombus Characteristics:An Explorative Study of Their Associations with Outcomes in Ischemic Stroke Patients

Author

Mojtahedi, Mahsa, Bruggeman, Agnetha E., van Voorst, Henk, Ponomareva, Elena, Kappelhof, Manon, van der Lugt, Aad, Hoving, Jan W., Dutra, Bruna G., Dippel, Diederik, Cavalcante, Fabiano, Yo, Lonneke, Coutinho, Jonathan, Brouwer, Josje, Treurniet, Kilian, Tolhuisen, Manon L., LeCouffe, Natalie, Arrarte Terreros, Nerea, Konduri, Praneeta R., van Zwam, Wim, Roos, Yvo, Majoie, Charles B.L.M., Emmer, Bart J., Marquering, Henk A., Mojtahedi, Mahsa, Bruggeman, Agnetha E., van Voorst, Henk, Ponomareva, Elena, Kappelhof, Manon, van der Lugt, Aad, Hoving, Jan W., Dutra, Bruna G., Dippel, Diederik, Cavalcante, Fabiano, Yo, Lonneke, Coutinho, Jonathan, Brouwer, Josje, Treurniet, Kilian, Tolhuisen, Manon L., LeCouffe, Natalie, Arrarte Terreros, Nerea, Konduri, Praneeta R., van Zwam, Wim, Roos, Yvo, Majoie, Charles B.L.M., Emmer, Bart J., and Marquering, Henk A.

Abstract

(1) Background: For acute ischemic strokes caused by large vessel occlusion, manually assessed thrombus volume and perviousness have been associated with treatment outcomes. However, the manual assessment of these characteristics is time-consuming and subject to inter-observer bias. Alternatively, a recently introduced fully automated deep learning-based algorithm can be used to consistently estimate full thrombus characteristics. Here, we exploratively assess the value of these novel biomarkers in terms of their association with stroke outcomes. (2) Methods: We studied two applications of automated full thrombus characterization as follows: one in a randomized trial, MR CLEAN-NO IV (n = 314), and another in a Dutch nationwide registry, MR CLEAN Registry (n = 1839). We used an automatic pipeline to determine the thrombus volume, perviousness, density, and heterogeneity. We assessed their relationship with the functional outcome defined as the modified Rankin Scale (mRS) at 90 days and two technical success measures as follows: successful final reperfusion, which is defined as an eTICI score of 2b-3, and successful first-pass reperfusion (FPS). (3) Results: Higher perviousness was significantly related to a better mRS in both MR CLEAN-NO IV and the MR CLEAN Registry. A lower thrombus volume and lower heterogeneity were only significantly related to better mRS scores in the MR CLEAN Registry. Only lower thrombus heterogeneity was significantly related to technical success; it was significantly related to a higher chance of FPS in the MR CLEAN-NO IV trial (OR = 0.55, 95% CI: 0.31–0.98) and successful reperfusion in the MR CLEAN Registry (OR = 0.88, 95% CI: 0.78–0.99). (4) Conclusions: Thrombus characteristics derived from automatic entire thrombus segmentations are significantly related to stroke outcomes.

Published
2024

30. Endovascular Treatment for Posterior Circulation Stroke in Routine Clinical Practice: Results of the Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands Registry

Author

Pirson, F. Anne V., Boodt, Nikki, Brouwer, Josje, Bruggeman, Agnetha A.E., den Hartog, Sanne J., Goldhoorn, Robert-Jan B., Langezaal, Lucianne C.M., Staals, Julie, van Zwam, Wim H., van der Leij, Christiaan, Brans, Rutger J.B., Majoie, Charles B.L.M., Coutinho, Jonathan M., Emmer, Bart J., Dippel, Diederik W.J., van der Lugt, Aad, Vos, Jan-Albert, van Oostenbrugge, Robert J., and Schonewille, Wouter J.

Published
2022
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34. Antibodies against Platelet Glycoproteins in Clinically Suspected VITT Patients.

Author

Meier, Romy T., Porcelijn, Leendert, Hofstede-van Egmond, Suzanne, Caram-Deelder, Camila, Coutinho, Jonathan M., Henskens, Yvonne M. C., Kruip, Marieke J. H. A., Stroobants, An K., Zwaginga, Jaap J., van der Schoot, C. Ellen, de Haas, Masja, and Kapur, Rick

Subjects
GLYCOPROTEINS, ADENOVIRUS diseases, BLOOD platelet activation, COVID-19 vaccines, BLOOD platelets, IMMUNOGLOBULINS
Abstract

Vaccine-induced thrombotic thrombocytopenia (VITT) is a rare but severe complication following COVID-19 vaccination, marked by thrombocytopenia and thrombosis. Analogous to heparin-induced thrombocytopenia (HIT), VITT shares similarities in anti-platelet factor 4 (PF4) IgG-mediated platelet activation via the FcγRIIa. To investigate the involvement of platelet-antibodies in VITT, we analyzed the presence of platelet-antibodies directed against glycoproteins (GP)IIb/IIIa, GPV and GPIb/IX in the serum of 232 clinically suspected VITT patients determined based on (suspicion of) occurrence of thrombocytopenia and/or thrombosis in relation to COVID-19 vaccination. We found that 19% of clinically suspected VITT patients tested positive for anti-platelet GPs: 39%, 32% and 86% patients tested positive for GPIIb/IIIa, GPV and GPIb/IX, respectively. No HIT-like VITT patients (with thrombocytopenia and thrombosis) tested positive for platelet-antibodies. Therefore, it seems unlikely that platelet-antibodies play a role in HIT-like anti-PF4-mediated VITT. Platelet-antibodies were predominantly associated with the occurrence of thrombocytopenia. We found no association between the type of vaccination (adenoviral vector vaccine versus mRNA vaccine) or different vaccines (ChAdOx1 nCoV-19, Ad26.COV2.S, mRNA-1273, BTN162b2) and the development of platelet-antibodies. It is essential to conduct more research on the pathophysiology of VITT, to improve diagnostic approaches and identify preventive and therapeutic strategies. [ABSTRACT FROM AUTHOR]

Published
2024
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35. Long-Term Clinical Implications of High-Risk Cardiac Computed Tomography Findings in Patients With Acute Ischemic Stroke.

Author

Rinkel, Leon A., Cramer, Olivia N., Özata, Z. Beyda, Beemsterboer, Chiel F. P., Guglielmi, Valeria, Shan Sui Nio, Bouma, Berto J., Boekholdt, S. Matthijs, Lobé, Nick H. J., Beenen, Ludo F. M., Marquering, Henk A., Majoie, Charles B. L. M., Roos, Yvo B. W. E. M., van Randen, Adrienne, Planken, R. Nils, and Coutinho, Jonathan M.

Published
2024
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37. Association between thrombus composition and stroke etiology in the MR CLEAN Registry biobank

Author

Hund, Hajo M., Boodt, Nikki, Hansen, Daniel, Haffmans, Willem A., Lycklama à Nijeholt, Geert J., Hofmeijer, Jeannette, Dippel, Diederik W. J., van der Lugt, Aad, van Es, Adriaan C. G. M., van Beusekom, Heleen M. M., Majoie, Charles B. L. M., Roos, Yvo B. W. E. M., van Oostenbrugge, Robert J., van Zwam, Wim H., Boiten, Jelis, Vos, Jan Albert, Jansen, Ivo G. H., Mulder, Maxim J. H. L., Goldhoorn, Robert- Jan B., Compagne, Kars C. J., Kappelhof, Manon, Brouwer, Josje, den Hartog, Sanne J., Hinsenveld, Wouter H., Roozenbeek, Bob, Emmer, Bart J., Coutinho, Jonathan M., Schonewille, Wouter J., Wermer, Marieke J. H., van Walderveen, Marianne A. A., Staals, Julie, Martens, Jasper M., de Bruijn, Sebastiaan F., van Dijk, Lukas C., van der Worp, H. Bart, Lo, Rob H., van Dijk, Ewoud J., Boogaarts, Hieronymus D., de Vries, J., de Kort, Paul L. M., van Tuijl, Julia, Peluso, Jo P., Fransen, Puck, van den Berg, Jan S. P., van Hasselt, Boudewijn A. A. M., Aerden, Leo A. M., Dallinga, René J., Uyttenboogaart, Maarten, Eschgi, Omid, Bokkers, Reinoud P. H., Schreuder, Tobien H. C. M. L., Heijboer, Roel J. J., Keizer, Koos, Yo, Lonneke S. F., den Hertog, Heleen M., Bulut, Tomas, Brouwers, Paul J. A. M., Sprengers, Marieke E. S., Jenniskens, Sjoerd F. M., van den Berg, René, Yoo, Albert J., Beenen, Ludo F. M., Postma, Alida A., Roosendaal, Stefan D., van der Kallen, Bas F. W., van den Wijngaard, Ido R., Bot, Joost, van Doormaal, Pieter-Jan, Meijer, Anton, Ghariq, Elyas, van Proosdij, Marc P., Krietemeijer, G. Menno, Dinkelaar, Wouter, Appelman, Auke P. A., Hammer, Bas, Pegge, Sjoert, van der Hoorn, Anouk, Vinke, Saman, Flach, H. Zwenneke, Lingsma, Hester F., el Ghannouti, Naziha, Sterrenberg, Martin, Pellikaan, Wilma, Sprengers, Rita, Elfrink, Marjan, Simons, Michelle, Vossers, Marjolein, de Meris, Joke, Vermeulen, Tamara, Geerlings, Annet, van Vemde, Gina, Simons, Tiny, Messchendorp, Gert, Nicolaij, Nynke, Bongenaar, Hester, Bodde, Karin, Kleijn, Sandra, Lodico, Jasmijn, Droste, Hanneke, Wollaert, Maureen, Verheesen, Sabrina, Jeurrissen, D., Bos, Erna, Drabbe, Yvonne, Sandiman, Michelle, Aaldering, Nicoline, Zweedijk, Berber, Vervoort, Jocova, Ponjee, Eva, Romviel, Sharon, Kanselaar, Karin, Barning, Denn, Venema, Esmee, Chalos, Vicky, Geuskens, Ralph R., van Straaten, Tim, Ergezen, Saliha, Harmsma, Roger R. M., Muijres, Daan, de Jong, Anouk, Berkhemer, Olvert A., Boers, Anna M. M., Huguet, J., Groot, P. F. C., Mens, Marieke A., van Kranendonk, Katinka R., Treurniet, Kilian M., Tolhuisen, Manon L., Alves, Heitor, Weterings, Annick J., Kirkels, Eleonora L.F., Voogd, Eva J. H. F., Schupp, Lieve M., Collette, Sabine L., Groot, Adrien E. D., LeCouffe, Natalie E., Konduri, Praneeta R., Prasetya, Haryadi, Arrarte-Terreros, Nerea, Ramos, Lucas A., Radiology and Nuclear Medicine, ACS - Microcirculation, ANS - Neurovascular Disorders, Neurology, ACS - Atherosclerosis & ischemic syndromes, ANS - Cellular & Molecular Mechanisms, ANS - Compulsivity, Impulsivity & Attention, Graduate School, Biomedical Engineering and Physics, AMS - Amsterdam Movement Sciences, ANS - Brain Imaging, Adult Psychiatry, APH - Methodology, ​Basic and Translational Research and Imaging Methodology Development in Groningen (BRIDGE), Damage and Repair in Cancer Development and Cancer Treatment (DARE), Cardiology, Radiology & Nuclear Medicine, Radiology and nuclear medicine, Internal medicine, Pediatrics, Amsterdam Neuroscience - Neurovascular Disorders, and CCA - Imaging and biomarkers

Subjects
Microscopy, Ischemic stroke, Radiology, Nuclear Medicine and imaging, Endovascular treatment, Neurology (clinical), Cardiology and Cardiovascular Medicine, Mechanical thrombectomy, Stent-retriever, Thrombus
Abstract

Purpose The composition of thrombi retrieved during endovascular thrombectomy (EVT) in acute ischemic stroke (AIS) due to large vessel occlusion (LVO) may differ depending on their origin. In this study, we investigated the association between thrombus composition and stroke etiology in a large population of patients from the Dutch MR CLEAN Registry treated with EVT in daily clinical practice. Methods The thrombi of 332 patients with AIS were histologically analyzed for red blood cells (RBC), fibrin/platelets (F/P), and white blood cells (leukocytes) using a machine learning algorithm. Stroke etiology was assessed using the Trial of Org 10,172 in acute stroke treatment (TOAST) classification. Results The thrombi of cardioembolic origin contained less RBC and more F/P than those of non-cardioembolic origin (25.8% vs 41.2% RBC [p = 0.003] and 67.1% vs 54.5% F/P [p = 0.004]). The likelihood of a non-cardioembolic source of stroke increased with increasing thrombus RBC content (OR 1.02; [95% CI 1.00–1.06] for each percent increase) and decreased with a higher F/P content (OR 1.02; [95% CI 1.00–1.06]). Thrombus composition in patients with a cardioembolic origin and undetermined origin was similar. Conclusion Thrombus composition is significantly associated with stroke etiology, with an increase in RBC and a decrease in F/P raising the odds for a non-cardioembolic cause. No difference between composition of cardioembolic thrombi and of undetermined origin was seen. This emphasizes the need for more extensive monitoring for arrhythmias and/or extended cardiac analysis in case of an undetermined origin.

Published
2023
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40. Routine transthoracic echocardiography in ischaemic stroke or transient ischaemic attack of undetermined cause: a prospective multicentre study

Author

van der Maten, Gerlinde, primary, Meijs, Matthijs F. L., additional, Timmer, Jorik R., additional, Brouwers, Paul J. A. M., additional, von Birgelen, Clemens, additional, Coutinho, Jonathan M., additional, Bouma, Berto J., additional, Kerkhoff, Henk, additional, Helming, Anne Mijn, additional, van Tuijl, Julia H., additional, van der Meer, Nicolet A., additional, Saxena, Ritu, additional, Ebink, Corné, additional, van der Palen, Job, additional, and den Hertog, Heleen M., additional

Published
2023
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41. Endovascular treatment of cerebral sinus thrombosis due to vaccine-induced immune thrombotic thrombocytopenia

Author

Weller, Johannes, primary, Krzywicka, Katarzyna, additional, van de Munckhof, Anita, additional, Dorn, Franziska, additional, Althaus, Katharina, additional, Bode, Felix J, additional, Bandettini di Poggio, Monica, additional, Buck, Brian, additional, Kleinig, Timothy, additional, Cordonnier, Charlotte, additional, Dizonno, Vanessa, additional, Duan, Jiangang, additional, Elkady, Ahmed, additional, Chew, Beng Lim Alvin, additional, Garcia-Esperon, Carlos, additional, Field, Thalia S, additional, Legault, Catherine, additional, Morin Martin, Mar, additional, Michalski, Dominik, additional, Pelz, Johann, additional, Schoenenberger, Silvia, additional, Nagel, Simon, additional, Petruzzellis, Marco, additional, Raposo, Nicolas, additional, Skjelland, Mona, additional, Zimatore, Domenico Sergio, additional, Aaron, Sanjith, additional, Sanchez van Kammen, Mayte, additional, Aguiar de Sousa, Diana, additional, Lindgren, Erik, additional, Jood, Katarina, additional, Scutelnic, Adrian, additional, Heldner, Mirjam R, additional, Poli, Sven, additional, Arauz, Antonio, additional, Conforto, Adriana B, additional, Putaala, Jukka, additional, Tatlisumak, Turgut, additional, Arnold, Marcel, additional, Coutinho, Jonathan M, additional, Günther, Albrecht, additional, Zimmermann, Julian, additional, and Ferro, José M, additional

Published
2023
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42. Direct oral anticoagulants for the treatment of cerebral venous thrombosis – a protocol of an international phase IV study

Author

van de Munckhof, Anita, primary, Sánchez van Kammen, Mayte, additional, Krzywicka, Katarzyna, additional, Aaron, Sanjith, additional, Aguiar de Sousa, Diana, additional, Antochi, Florina, additional, Arauz, Antonio, additional, Barboza, Miguel A., additional, Conforto, Adriana B., additional, Dentali, Francesco, additional, Galdames Contreras, Daniel, additional, Ji, Xunming, additional, Jood, Katarina, additional, Heldner, Mirjam R., additional, Hernández-Pérez, María, additional, Kam, Wayneho, additional, Kleinig, Timothy J., additional, Kristoffersen, Espen S., additional, Leker, Ronen R., additional, Lemmens, Robin, additional, Poli, Sven, additional, Yeşilot, Nilüfer, additional, Wasay, Mohammad, additional, Wu, Teddy Y., additional, Arnold, Marcel, additional, Lucas-Neto, Lia, additional, Middeldorp, Saskia, additional, Putaala, Jukka, additional, Tatlisumak, Turgut, additional, Ferro, José M., additional, and Coutinho, Jonathan M., additional

Published
2023
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47. Collateral Circulation and Outcome in Atherosclerotic Versus Cardioembolic Cerebral Large Vessel Occlusion

Author

Guglielmi, Valeria, LeCouffe, Natalie E., Zinkstok, Sanne M., Compagne, Kars C.J., Eker, Reyhan, Treurniet, Kilian M., Tolhuisen, Manon. L., van der Worp, H. Bart, Jansen, Ivo G.H., van Oostenbrugge, Robert J., Marquering, Henk A., Dippel, Diederik W.J., Emmer, Bart J., Majoie, Charles B.L.M., Roos, Yvo B.W.E.M., and Coutinho, Jonathan M.

Published
2019
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50. Sex differences in cerebral venous sinus thrombosis after adenoviral vaccination against COVID-19

Author

Scutelnic, Adrian, primary, van de Munckhof, Anita, additional, Krzywicka, Katarzyna, additional, van Kammen, Mayte Sánchez, additional, Lindgren, Erik, additional, Cordonnier, Charlotte, additional, Kleinig, Timothy J, additional, Field, Thalia S, additional, Poli, Sven, additional, Lemmens, Robin, additional, Middeldorp, Saskia, additional, Aaron, Sanjith, additional, Borhani-Haghighi, Afshin, additional, Arauz, Antonio, additional, Kremer Hovinga, Johanna A, additional, Günther, Albrecht, additional, Putaala, Jukka, additional, Wasay, Mohammad, additional, Conforto, Adriana Bastos, additional, de Sousa, Diana Aguiar, additional, Jood, Katarina, additional, Tatlisumak, Turgut, additional, Ferro, José M, additional, Coutinho, Jonathan M, additional, Arnold, Marcel, additional, Heldner, Mirjam R, additional, Antonenko, Kateryna, additional, Mbroh, Joshua, additional, Brodard, Justine, additional, Hooshmandi, Etrat, additional, Dizonno, Vanessa, additional, Devroye, Annemie, additional, Ciccone, Alfonso, additional, Wittstock, Matthias, additional, Zimmermann, Julian, additional, Bode, Felix J., additional, Skjelland, Mona, additional, Duan, Jiangang, additional, Hiltunen, Sini, additional, Zuurbier, Susanna M., additional, Petruzzellis, Marco, additional, Sharma, Aarti R., additional, Ghoreishi, Abdoreza, additional, Elkady, Ahmed, additional, Negro, Alberto, additional, Gutschalk, Alexander, additional, Schoenenberger, Silvia, additional, Nagel, Simon, additional, Buture, Alina, additional, Cervera, Alvaro, additional, Paiva Nunes, Ana, additional, Romina Montané Baños, Ana, additional, Tiede, Andreas, additional, Puthuppallil, Anemon, additional, Tuladhar, Anil M., additional, Mengel, Annerose, additional, Medina, Antonio, additional, Hellström Vogel, Åslög, additional, Tawa, Audrey, additional, Aujayeb, Avinash, additional, Ramasamy, Balakrishnan, additional, Casolla, Barbara, additional, Lim Alvin Chew, Beng, additional, Ziaadini, Bentalhoda, additional, Varkey Maramattom, Boby, additional, Buck, Brian, additional, Zanferrari, Carla, additional, Garcia-Esperon, Carlos, additional, Vayne, Caroline, additional, Legault, Catherine, additional, Jacobi, Christian, additional, Pfrepper, Christian, additional, Pelz, Johann, additional, Wahl, Christoph, additional, Kern, Rolf, additional, Tracol, Clement, additional, Soriano, Cristina, additional, Guisado-Alonso, Daniel, additional, Bougon, David, additional, Bal, Deepti, additional, Sergio Zimatore, Domenico, additional, Michalski, Dominik, additional, Blacquiere, Dylan, additional, Johansson, Elias, additional, Cuadrado-Godia, Elisa, additional, Sadeghi-Hokmabadi, Elyar, additional, Carrera, Emmanuel, additional, De Maistre, Emmanuel, additional, Saxhaug Kristoffersen, Espen, additional, Bonneville, Fabrice, additional, Geeraerts, Thomas, additional, Vuillier, Fabrice, additional, Giammello, Fabrizio, additional, D’Onofrio, Florindo, additional, Grillo, Francesco, additional, Caparros, François, additional, Susen, Sophie, additional, Maier, Frank, additional, Tsivgoulis, Georgios, additional, Gulli, Giosue, additional, Frisullo, Giovanni, additional, Franchineau, Guillaume, additional, Cangür, Hakan, additional, Katzberg, Hans, additional, Mozhdehipanah, Hossein, additional, Sibon, Igor, additional, Baharoglu, M. Irem, additional, Masjuan, Jaime, additional, Brar, Jaskiran, additional, Payen, Jean-Francois, additional, Burrow, Jim, additional, Fernandes, João, additional, Octavio López Esparza, Jorge, additional, Oen, Joyce, additional, Schouten, Judith, additional, Ng, Karl, additional, Chatterton, Sophie, additional, Wronski, Miriam, additional, Althaus, Katharina, additional, Garambois, Katia, additional, Derex, Laurent, additional, Puy, Laurent, additional, Poorsaadat, Leila, additional, Valler, Lenise, additional, Januzi de Almeida Rocha, Letícia, additional, Humbertjean, Lisa, additional, Lebrato Hernandez, Lucia, additional, Murillo-Bonilla, Luis, additional, Kellermair, Lukas, additional, Morin Martin, Mar, additional, Sofia Cotelli, Maria, additional, Hernandez Perez, Maria, additional, Zedde, Marialuisa, additional, Carvalho Dias, Mariana, additional, Dubois, Marie-Cecile, additional, Carvalho, Marta, additional, Ghiasian, Masoud, additional, Umaiorubahan, Meenakshisundaram, additional, Kumar Karunakaran, Ravi, additional, Roozbeh, Mehrdad, additional, Romoli, Michele, additional, Miranda, Miguel, additional, Saadatnia, Mohammad, additional, Bandettini di Poggio, Monica, additional, Scholz, Moritz J., additional, Kahnis, Robert, additional, Almasi-Dooghaee, Mostafa, additional, Hoseininejad Mir, Nahid, additional, Ichaporia, Nasli R., additional, Kumar Paramasivan, Naveen, additional, Erat Sreedharan, Sapna, additional, Sylaja, PN, additional, Raposo, Nicolas, additional, Fadakar, Nima, additional, Kruyt, Nyika, additional, Detante, Olivier, additional, Cuisenier, Pauline, additional, Huet, Olivier, additional, Sharma, Pankaj, additional, Candelaresi, Paolo, additional, Scoppettuolo, Pasquale, additional, Reiner, Peggy, additional, Nemati, Reza, additional, Vieira, Ricardo, additional, Goh, Rudy, additional, Murphy, Seán, additional, Timsit, Serge, additional, Coutts, Shelagh, additional, Sharma, Shyam S., additional, Bal, Simerpreet, additional, Kaul, Subhash, additional, Karapanayiotides, Theodoros, additional, Cox, Thomas, additional, Gattringer, Thomas, additional, Mathew, Thomas, additional, Bartsch, Thorsten, additional, Shaygannejad, Vahid, additional, Garcia-Talavera, Veronica, additional, Palma, Vincenzo, additional, Arslan, Yıldız, additional, Mirzaasgari, Zahra, additional, Yavari, Zeinab, additional, Zamani, Zohreh, additional, Bakchoul, Tamam, additional, Levi, Marcel, additional, and van Gorp, Eric C.M., additional

Published
2023
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