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13 results on '"Coumans, Audrey"'

1. Factors associated with poor outcome in fetuses prenatally diagnosed with sacrococcygeal teratoma

Author

van Heurn, Lieke J., Coumans, Audrey B.C., Derikx, Joep P.M., Bekker, Mireille N., Bilardo, Katia M., Duin, Leonie K., Knapen, Maarten F.C.M., Pajkrt, Eva, Sikkel, Esther, van Heurn, L. W.Ernest, Oepkes, Dick, van Heurn, Lieke J., Coumans, Audrey B.C., Derikx, Joep P.M., Bekker, Mireille N., Bilardo, Katia M., Duin, Leonie K., Knapen, Maarten F.C.M., Pajkrt, Eva, Sikkel, Esther, van Heurn, L. W.Ernest, and Oepkes, Dick

Abstract

Aim of the study: Outcome of fetuses, prenatally diagnosed with sacrococcygeal teratoma (SCT), is still poorly documented. This study assesses the incidence and prenatal predictors of outcome in all fetuses prenatally diagnosed with SCT. Methods: This is a retrospective study on all fetuses prenatally diagnosed with SCT from 1998 to 2018 in the Netherlands. Poor outcome was defined as terminations of pregnancy (TOP) because of expected unfavorable outcome, intrauterine fetal death, or early neonatal death. Potential risk factors for poor outcome were analyzed. Main results: Eighty-four fetuses were included. Sixteen (19.0%) TOPs were excluded from statistical analysis. Eleven of the remaining 68 fetuses had poor outcome. Overall mortality was 32.1%, with a mortality excluding TOPs of 13.1%. Thirteen fetal interventions were performed in 11 (13.1%) fetuses. Potential risk factors for poor outcome were the presence of fetal hydrops (OR: 21.0, CI: 2.6–275.1, p = 0.012) and cardiomegaly (OR: 10.3, CI: 1.9–55.8, p = 0.011). Conclusions: The overall mortality of fetuses prenatally diagnosed with SCTs including tTOP was 32.1%. This high mortality rate was mainly due to termination of pregnancy. Mortality excluding TOP was 13.1%. Potential risk factors for poor outcome were fetal hydrops and cardiomegaly.

Published
2021

2. Factors associated with poor outcome in fetuses prenatally diagnosed with sacrococcygeal teratoma

Author

MS Verloskunde, Child Health, Circulatory Health, van Heurn, Lieke J., Coumans, Audrey B.C., Derikx, Joep P.M., Bekker, Mireille N., Bilardo, Katia M., Duin, Leonie K., Knapen, Maarten F.C.M., Pajkrt, Eva, Sikkel, Esther, van Heurn, L. W.Ernest, Oepkes, Dick, MS Verloskunde, Child Health, Circulatory Health, van Heurn, Lieke J., Coumans, Audrey B.C., Derikx, Joep P.M., Bekker, Mireille N., Bilardo, Katia M., Duin, Leonie K., Knapen, Maarten F.C.M., Pajkrt, Eva, Sikkel, Esther, van Heurn, L. W.Ernest, and Oepkes, Dick

Published
2021

3. Is there still a role for nuchal translucency measurement in the changing paradigm of first trimester screening?

Author

MS Verloskunde, Child Health, Bardi, Francesca, Bosschieter, Pien, Verheij, Joke, Go, Attie, Haak, Monique, Bekker, Mireille, Sikkel, Esther, Coumans, Audrey, Pajkrt, Eva, Bilardo, Caterina, MS Verloskunde, Child Health, Bardi, Francesca, Bosschieter, Pien, Verheij, Joke, Go, Attie, Haak, Monique, Bekker, Mireille, Sikkel, Esther, Coumans, Audrey, Pajkrt, Eva, and Bilardo, Caterina

Published
2020

5. Women’s Experience with Non-Invasive Prenatal Testing and Emotional Well-being and Satisfaction after Test-Results

Author

van Schendel, Rachèl V., Page-Christiaens, G. C.M.Lieve, Beulen, Lean, Bilardo, Caterina M., de Boer, Marjon A, Coumans, Audrey B C, Faas, Brigitte H W, van Langen, Irene M., Lichtenbelt, Klaske D., van Maarle, Merel C, Macville, Merryn V E, Oepkes, Dick, Pajkrt, Eva, Henneman, Lidewij, and for the Dutch NIPT Consortium

Subjects
Satisfaction, Genetics(clinical), Anxiety, Prenatal Screening, NIPT, Non-invasive Prenatal Testing, Reassurance
Abstract

Increasingly, high-risk pregnant women opt for non-invasive prenatal testing (NIPT) instead of invasive diagnostic testing. Since NIPT is less accurate than invasive testing, a normal NIPT result might leave women less reassured. A questionnaire study was performed among pregnant women with elevated risk for fetal aneuploidy based on first-trimester combined test (risk ≥1:200) or medical history, who were offered NIPT in the nationwide Dutch TRIDENT study. Pre- and post-test questionnaires (n = 682) included measures on: experiences with NIPT procedure, feelings of reassurance, anxiety (State-Trait Anxiety Inventory, STAI), child-related anxiety (PRAQ-R), and satisfaction. The majority (96.1%) were glad to have been offered NIPT. Most (68.5%) perceived the waiting time for NIPT results (mean: 15 days, range 5–32) as (much) too long. Most women with a normal NIPT result felt reassured (80.9%) or somewhat reassured (15.7%). Levels of anxiety and child-related anxiety were significantly lower after receiving a normal NIPT result as compared to the moment of intake (p

Published
2017

6. Women’s Experience with Non-Invasive Prenatal Testing and Emotional Well-being and Satisfaction after Test-Results

Author

UMC Utrecht, MS Verloskunde, Genetica Klinische Genetica, Child Health, van Schendel, Rachèl V., Page-Christiaens, G. C.M.Lieve, Beulen, Lean, Bilardo, Caterina M., de Boer, Marjon A, Coumans, Audrey B C, Faas, Brigitte H W, van Langen, Irene M., Lichtenbelt, Klaske D., van Maarle, Merel C, Macville, Merryn V E, Oepkes, Dick, Pajkrt, Eva, Henneman, Lidewij, for the Dutch NIPT Consortium, UMC Utrecht, MS Verloskunde, Genetica Klinische Genetica, Child Health, van Schendel, Rachèl V., Page-Christiaens, G. C.M.Lieve, Beulen, Lean, Bilardo, Caterina M., de Boer, Marjon A, Coumans, Audrey B C, Faas, Brigitte H W, van Langen, Irene M., Lichtenbelt, Klaske D., van Maarle, Merel C, Macville, Merryn V E, Oepkes, Dick, Pajkrt, Eva, Henneman, Lidewij, and for the Dutch NIPT Consortium

Published
2017

7. Trial by Dutch Laboratories for Evaluation of Non-Invasive Prenatal Testing. Part I - Clinical Impact

Author

Oepkes, Dick, Page-Christiaens, Lieve C, Bax, Caroline J, Bekker, Mireille N, Bilardo, Catia M, Boon, Elles M J, Schuring-Blom, G Heleen, Coumans, Audrey B C, Faas, Brigitte H, Galjaard, Robert-Jan H, Go, Attie T, Henneman, Lidewij, Macville, Merryn V E, Pajkrt, Eva, Suijkerbuijk, Ron F, Huijsdens-vanAmsterdam, Karin, Van Opstal, Diane, Verweij, E J Joanne, Weiss, Marjan M, Sistermans, Erik A, and Dutch NIPT Consortium

Subjects
Journal Article
Abstract

OBJECTIVE: To evaluate the clinical impact of nationwide implementation of genome-wide Non-Invasive Prenatal Testing (NIPT) in pregnancies at increased risk for fetal trisomies 21, 18 and 13. METHOD: Women with elevated risk based on first trimester combined testing (FCT ≥ 1:200) or medical history, not advanced maternal age alone, were offered NIPT as contingent screening test, performed by Dutch University Medical laboratories. We analyzed uptake, test performance, redraw/failure rate, turn-around time and pregnancy outcome. RESULTS: Between April 1st and September 1st, 2014, 1413/23232 (6%) women received a high-risk FCT result. Of these, 1211 (85.7%) chose NIPT. 179 women had NIPT based on medical history. 1386/1390 (99.7%) women received a result, 6 (0.4%) after redraw. Mean turn-around time was 14 days. Follow-up was available in 1376 (99.0%) pregnancies. NIPT correctly predicted 37/38 (97.4%) trisomies 21, 18 or 13 (29/30, 4/4 and 4/4 respectively). 5/1376 (0.4%) cases proved to be false positives: trisomies 21 (n = 2), 18 (n = 1) and 13 (n = 2). Estimated reduction in invasive testing was 62%. CONCLUSION: Introduction of NIPT in the Dutch National healthcare-funded Prenatal Screening Program resulted in high uptake and a vast reduction of invasive testing. Our study supports offering NIPT to pregnant women at increased risk for fetal trisomy.

Published
2016

8. Trial by Dutch Laboratories for Evaluation of Non-Invasive Prenatal Testing. Part II - Women's Perspectives

Author

van Schendel, Rachel V, Page-Christiaens, Lieve, Beulen, Lean, Bilardo, Catia M, de Boer, Marjon A, Coumans, Audrey B C, Faas, Brigitte H, van Langen, Irene M, Lichtenbelt, Klaske D, van Maarle, Merel C, Macville, Merryn V E, Oepkes, Dick, Pajkrt, Eva, Henneman, Lidewij, Dutch NIPT Consortium, van Schendel, Rachel V, Page-Christiaens, Lieve, Beulen, Lean, Bilardo, Catia M, de Boer, Marjon A, Coumans, Audrey B C, Faas, Brigitte H, van Langen, Irene M, Lichtenbelt, Klaske D, van Maarle, Merel C, Macville, Merryn V E, Oepkes, Dick, Pajkrt, Eva, Henneman, Lidewij, and Dutch NIPT Consortium

Published
2016

9. Trial by Dutch Laboratories for Evaluation of Non-Invasive Prenatal Testing. Part II - Women's Perspectives

Author

MS Verloskunde, Other research (not in main researchprogram), Genetica Klinische Genetica, Child Health, van Schendel, Rachel V, Page-Christiaens, Lieve, Beulen, Lean, Bilardo, Catia M, de Boer, Marjon A, Coumans, Audrey B C, Faas, Brigitte H, van Langen, Irene M, Lichtenbelt, Klaske D, van Maarle, Merel C, Macville, Merryn V E, Oepkes, Dick, Pajkrt, Eva, Henneman, Lidewij, Dutch NIPT Consortium, MS Verloskunde, Other research (not in main researchprogram), Genetica Klinische Genetica, Child Health, van Schendel, Rachel V, Page-Christiaens, Lieve, Beulen, Lean, Bilardo, Catia M, de Boer, Marjon A, Coumans, Audrey B C, Faas, Brigitte H, van Langen, Irene M, Lichtenbelt, Klaske D, van Maarle, Merel C, Macville, Merryn V E, Oepkes, Dick, Pajkrt, Eva, Henneman, Lidewij, and Dutch NIPT Consortium

Published
2016

10. Trial by Dutch Laboratories for Evaluation of Non-Invasive Prenatal Testing. Part I - Clinical Impact

Author

MS Verloskunde, Other research (not in main researchprogram), Child Health, Genetica Sectie Genoomdiagnostiek, Cancer, Oepkes, Dick, Page-Christiaens, Lieve C, Bax, Caroline J, Bekker, Mireille N, Bilardo, Catia M, Boon, Elles M J, Schuring-Blom, G Heleen, Coumans, Audrey B C, Faas, Brigitte H, Galjaard, Robert-Jan H, Go, Attie T, Henneman, Lidewij, Macville, Merryn V E, Pajkrt, Eva, Suijkerbuijk, Ron F, Huijsdens-vanAmsterdam, Karin, Van Opstal, Diane, Verweij, E J Joanne, Weiss, Marjan M, Sistermans, Erik A, Dutch NIPT Consortium, MS Verloskunde, Other research (not in main researchprogram), Child Health, Genetica Sectie Genoomdiagnostiek, Cancer, Oepkes, Dick, Page-Christiaens, Lieve C, Bax, Caroline J, Bekker, Mireille N, Bilardo, Catia M, Boon, Elles M J, Schuring-Blom, G Heleen, Coumans, Audrey B C, Faas, Brigitte H, Galjaard, Robert-Jan H, Go, Attie T, Henneman, Lidewij, Macville, Merryn V E, Pajkrt, Eva, Suijkerbuijk, Ron F, Huijsdens-vanAmsterdam, Karin, Van Opstal, Diane, Verweij, E J Joanne, Weiss, Marjan M, Sistermans, Erik A, and Dutch NIPT Consortium

Published
2016

12. Systemic endotoxin administration results in increased S100B protein blood levels and periventricular brain white matter injury in the preterm fetal sheep.

Author

Garnier, Yve, Berger, Richard, Alm, Stephanie, Von Duering, Monika U, Coumans, Audrey Bc, Michetti, Fabrizio, Bruschettini, Matteo, Lituania, Mario, Hasaart, Tom Hm, Gazzolo, Diego, Garnier, Yves, Michetti, Fabrizio (ORCID:0000-0003-2546-0532), Garnier, Yve, Berger, Richard, Alm, Stephanie, Von Duering, Monika U, Coumans, Audrey Bc, Michetti, Fabrizio, Bruschettini, Matteo, Lituania, Mario, Hasaart, Tom Hm, Gazzolo, Diego, Garnier, Yves, and Michetti, Fabrizio (ORCID:0000-0003-2546-0532)

Abstract

OBJECTIVE: Intrauterine infection is suggested to cause perinatal brain white matter injury. The aim of the present study was to clarify, whether intravenous application of endotoxin results in neuropathological findings and increased blood levels of the S100B protein, which is a consolidated marker of brain injury. METHODS: Twenty-one fetal sheep were chronically catheterized at a mean gestational age of 107+/-1 days (0.7 of gestation). Three days after surgery fetuses received either 100 (n=9), 500 (n=5) or 2500ng (n=1) lipopolysaccharide (LPS; E. coli; O127:B8, Sigma-Aldrich) or 2ml 0.9% saline (n=6) i.v. S100B protein blood levels were assessed before during and after LPS or placebo administration. Brain damage was evaluated by light microscopy. Selected areas of the periventricular white matter were also examined by electron microscopy. RESULTS: Histopathological screening revealed no evidence for cortical neuronal cell damage in both groups. However, LPS treatment resulted in inflammatory infiltrates in all animals and cystic lesions in the periventricular brain white matter in two fetuses. On electron micrographs, infiltrate forming cells appeared to be activated microglia. S100B protein blood levels were significantly higher in the LPS group at 1h (p<0.01) after LPS injection, peaking at 3h (p<0.001) and returning to baseline between 12 and 72h. CONCLUSION: Intravenous application of endotoxin caused focal periventricular brain white matter injury, inflammation and an increase in S100B protein release. It is suggested that longitudinal investigations of S100B protein blood levels offer a tool for the early detection of white matter injury.

Published
2006

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